Integrated filter membrane injector device

Abstract

The utility model discloses an integrated filter membrane injector device, which relates to the technical field of analytical chemistry instruments and comprises an injector and an integrated filter membrane unit matched with a medicine bottle, the integrated filter membrane unit is fixed at an outlet of the head of the injector and consists of a lower shell, a microporous filter membrane, a water-resistant adsorption coating and an upper shell, and the upper shell is fixed on the lower shell. The water adsorption resistant coating is arranged on the surface of the microfiltration membrane, the pore diameter of the microfiltration membrane is 0.1-5 [mu] m, the water adsorption resistant coating covers the surface of the microfiltration membrane, the water adsorption resistant coating is composed of polyethylene glycol (PEG) and a hydrophobic anchoring layer and is used for reducing adhesion of biomolecules, the water adsorption resistant coating covers the surface of the microfiltration membrane, and the adhesion of the biomolecules is reduced through the water adsorption resistant coating, so that the water adsorption resistance of the microfiltration membrane is improved. Therefore, long-acting adsorption resistance is realized.

Description

TECHNICAL FIELD

[0001] The patent belongs to the technical field of analytical chemistry instruments, and specifically relates to a novel disposable filter membrane syringe for rapid sample filtration. BACKGROUND

[0002] The origin of the needle filter membrane syringe can be traced back to the mid-20th century. With the increasing demand for pure liquids in the fields of chemical analysis, biomedical science, etc., traditional filtration methods such as filter paper filtration cannot meet the requirements of high precision and high efficiency. Therefore, scientists began to develop needle filter membrane syringes based on microporous filter membrane technology. Initially, it was mainly used in the fields of chemical analysis and biological sample processing in laboratories. With the continuous progress of material science and manufacturing technology, the performance of the needle filter membrane syringe has been greatly improved. The filter membrane material is constantly enriched, the pore size control is more accurate, and the manufacturing process is more advanced, making its application gradually expand to the pharmaceutical, food and beverage, environmental monitoring, and other industries.

[0003] The Chinese utility model patent with the publication number CN203763950U discloses a needle cylinder type filter membrane filtration assembly. This device connects the water outlet port of the syringe to the water inlet port of the needle cylinder type filter membrane filter. By slowly pushing the syringe piston push rod, the filter membrane filtration process can be completed quickly and conveniently, and solid-liquid separation can be achieved.

[0004] The above-mentioned device has the following defects in use compared with the traditional needle filter membrane syringe: 1. The filter membrane in the traditional needle filter membrane syringe is easy to be blocked. Proteins, colloids, and other substances are quickly adsorbed on the surface of the filter membrane, causing the filter holes on the filter membrane to be blocked by proteins, colloids, and other substances, resulting in the inability to use the filter membrane; 2. The assembly of the traditional needle filter membrane syringe is complex. The user needs to manually install the filter membrane. If the filter membrane is not installed in place or incorrectly, there is a risk of leakage when using the filter membrane for filtration; 3. In the laboratory, if multiple people operate at the same time, it is possible that an experimental staff member repeatedly uses the same filter membrane, causing cross-contamination and affecting the experimental results. UTILITY MODEL CONTENT

[0005] In view of the above technical problems, the utility model provides the following technical solutions:

[0006] The integrated filter membrane syringe device includes a syringe and an integrated filter membrane unit that cooperates with a medicine bottle. The syringe is composed of a barrel and a piston, and both are made of polypropylene (PP) or polyethylene (PE).

[0007] Further, the integrated filter membrane unit is fixed at the outlet of the syringe head, and the integrated filter membrane unit is composed of a lower shell, a microporous filter membrane, a water adsorption resistant coating and an upper shell, the pore size of the microporous filter membrane is 0.1-5 microns, the water adsorption resistant coating is covered on the surface of the microporous filter membrane, and the water adsorption resistant coating is composed of polyethylene glycol (PEG) and a hydrophobic anchor layer, so as to reduce the adhesion of biological molecules.

[0008] Further, the microporous filter membrane has a thickness of 100-300 microns.

[0009] Further, the integrated filter membrane unit is fused with the syringe head by hot melt sealing, so as to be connected, and the hot melt sealing strength is greater than 5 N / mm 2 (MPa); the integrated filter membrane unit can also be welded with the syringe head by ultrasonic welding, and the welding area of the syringe and the integrated filter membrane unit forms a continuous annular sealing band, and the ultrasonic welding strength is 8-15 N / mm 2 ()。

[0010] The beneficial effects of the utility model compared with the prior art are: 1, the device reduces the adhesion of biological molecules by covering the water adsorption resistant coating on the surface of the microporous filter membrane, so as to realize long-acting anti-adsorption;2, the device is welded with the barrel by the integrated filter membrane unit, so as to be permanently fixed, prevent leakage and seepage, simplify the structure and delete redundant components;3, the device is set by integration, so that the device is discarded as a whole after filtration, and cross contamination is avoided. BRIEF DESCRIPTION OF DRAWINGS

[0011] Figure 1 It is the whole structure schematic diagram of the utility model.

[0012] Figure 2 It is the lower shell structure schematic diagram of the utility model.

[0013] Figure 3 It is the syringe schematic diagram of the utility model.

[0014] Figure 4 It is the integrated filter membrane unit schematic diagram of the utility model.

[0015] Figure 5 It is the water adsorption resistant coating structure schematic diagram of the utility model.

[0016] Figure 6 It is the hot melt sealing structure schematic diagram of the utility model.

[0017] Figure 7 It is the ultrasonic welding structure schematic diagram of the utility model.

[0018] Reference numerals: 101-syringe; 102-bore; 103-piston; 104-integrated filter membrane unit; 105-drug vial; 401-lower shell; 402-microporous filter membrane; 403-water-resistant coating; 404-upper shell. Detailed Implementation

[0019] like Figures 1 to 3 As shown, the integrated filter membrane injector device includes an injector 101 and an integrated filter membrane unit 104 that cooperates with a drug vial 105. The injector 101 consists of a barrel 102 and a piston 103, which slides within the barrel 102. The barrel 102 and the piston 103 are made of polypropylene (PP) or polyethylene (PE) material.

[0020] like Figure 2 , Figure 4 , Figure 5 As shown, the integrated filter membrane unit 104 includes a lower shell 401 and an upper shell 404, which serve a protective function. An anti-water-adsorption coating 403 and a microporous filter membrane 402 are disposed within the lower shell 401 and the upper shell 404. The anti-water-adsorption coating 403 covers the surface of the microporous filter membrane 402 and is composed of polyethylene glycol (PEG) and a hydrophobic anchoring layer, thus significantly reducing and minimizing biomolecule adhesion. The pore size of the microporous filter membrane 402 is 0.1-5 μm. The effective filtration area of ​​the microporous filter membrane 402 is 20% to 40% larger than that of the traditional needle-type microporous filter membrane 402, and the thickness of the microporous filter membrane 402 is 100-300 μm. During the use of this device, the syringe 101 and the integrated filter membrane unit 104 are integrated. When the liquid passes through the integrated filter membrane unit 104 and the anti-water adsorption coating 403, filtration will be performed. The filtered liquid is stored in the injection drug bottle 105. After the device is used, it can be directly discarded to avoid reuse.

[0021] like Figure 1 , Figure 6 , Figure 7 As shown, the integrated filter membrane unit 104 is fixedly connected to the head of the syringe 101. The integrated filter membrane unit 104 can be fixedly connected to the syringe 101 in the following ways:

[0022] 1. Heat-melt sealing: The edge of the upper shell 404 is heat-melted with the head of the syringe 101, and the sealing strength of the upper shell 404 and the syringe 101 after heat-melting is ≥5N / mm. 2 (MPa);

[0023] 2. The upper shell 404 edge is ultrasonically welded to the syringe 101 head, the weld area forms a continuous annular seal band, the seal strength of the upper shell 404 and the syringe 101 after heat fusion is 8-15 N / mm 2 (MPa).

[0024] The preparation method of the anti-sorption coating used in the integrated filter membrane syringe device comprises:

[0025] Step one: surface plasma treatment of the microporous filter membrane 402 to increase active groups;

[0026] Step two: immerse the microporous filter membrane 402 in a PEG-polylactic acid (PEG-PLA) copolymer solution to form a stable anti-water absorption coating 403 on the surface of the microporous filter membrane 402.

Claims

1. An integrated filter membrane injector device, characterized in that, Includes a syringe (101) and an integrated filter membrane unit (104) that cooperates with a medicine bottle (105). The syringe (101) consists of a barrel (102) and a piston (103), both of which are made of polypropylene or polyethylene. The integrated filter membrane unit (104) is fixed at the outlet of the syringe head (101). The integrated filter membrane unit (104) consists of a lower shell (401), a microporous filter membrane (402), a water-resistant coating (403), and an upper shell (404). The pore size of the microporous filter membrane (402) is 0.1-5μm. The water-resistant coating (403) covers the surface of the microporous filter membrane (402). The water-resistant coating (403) is composed of polyethylene glycol and a hydrophobic anchoring layer.

2. The integrated filter membrane injector device according to claim 1, characterized in that: The thickness of the microporous filter membrane (402) is 100-300 μm.

3. The integrated filter membrane injector device according to claim 1, characterized in that, The integrated filter membrane unit (104) is connected to the syringe (101) head by heat fusion sealing, and the heat fusion sealing strength is greater than 5 N / mm. 2 The integrated filter membrane unit (104) can also be ultrasonically welded to the head of the syringe (101), forming a continuous annular sealing band between the syringe (101) and the integrated filter membrane unit (104). The ultrasonic welding strength is 8-15 N / mm. 2 .

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