RNA CONTAINING MODIFIED NUCLEOSITES AND METHODS OF USING THE SAME

Abstract

This invention provides RNA, oligonucleotide and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising them, methods of synthesizing them and methods for gene replacement, gene therapy, gene transcription suppression and delivery of therapeutic proteins to tissue in vivo comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligonucleotide and polyribonucleotide molecules.