Pharmaceutical or dietary composition to block peptide synthesis by ribosomes.

Abstract

A pharmaceutical or dietary composition containing zinc combined with at least one zinc ionophore, magnesium, vitamin B6, and vitamin D, and usable for blocking the production of polypeptides by ribosomes. According to the invention, this composition can be used to block viral replication, bacterial multiplication, and / or cancer cells.

Description

Title of the invention: Pharmaceutical or dietary composition for blocking peptide synthesis by ribosomes.

[0001] The present invention relates to a new therapeutic use of zinc associated with at least one zinc ionophore, magnesium, vitamin B6, vitamin D and usable to block the production of peptides by ribosomes during viral, bacterial infections and in cancerous conditions. Some definitions

[0002] To better understand this text, it is advisable to define some of the words and terms used in it. Most of the terms and words used are defined in the Garnier Delamare Illustrated Dictionary of Medical Terms, 28th edition.

[0003] Antibacterial: having the effect of fighting bacteria. A substance possessing this property. Sometimes it is called an antimicrobial (having the effect of fighting microbes).

[0004] Antibiotic: That which opposes life. Said of substances (such as penicillin and sulfonamides) which prevent the development of certain microorganisms into which they penetrate and whose metabolism they disrupt or which destroy them.

[0005] Antifungals: Synonym: antimycotic. That which opposes the development of fungi (yeasts). Antifungals can destroy (fungicides) or stop the growth (fungistatics) of fungi.

[0006] Excipient. This is a vehicle for a medicinal product. It is a substance into which the active ingredients are incorporated to make them easily absorbed.

[0007] Nutrients: food substances that can be directly and completely assimilated without undergoing the modifications of digestion and that can be introduced by intravenous injection. Example: glucose, vitamins, mineral salts, etc.

[0008] Medicinal product: Substance or combination of substances presented as having curative or preventive properties with regard to human or animal diseases, as well as any product that can be administered to humans or animals for the purpose of establishing a medical diagnosis, restoring, correcting or modifying their organic functions.

[0009] Mitosis: A mode of indirect cell division characterized by a series of changes in the chromatin of the nucleus. Mitosis is characterized by the duplication of the chromosomes of the parent cell, which allows the daughter cells to receive a number of chromosomes equal to that of the mother cell.

[0010] Anticancer or antineoplastic is a drug intended to block the proliferation of cancer cells - the neoplasm referring to a tumor or cancer.

[0011] Antiviral: That which opposes a virus. A substance possessing this property. A distinction is made between virucides (antiseptics and disinfectants) and virustatics, which inhibit viral multiplication (reversible inhibition of viral replication). According to the invention, it is a composition having virustatic properties.

[0012] Ribosome: Ribosomes are ribonucleoprotein complexes present in eukaryotic and prokaryotic cells. Extremely well conserved throughout evolution, their function is to synthesize proteins by decoding the information contained in messenger RNA.

[0013] Ionophore: An ionophore is a hydrophobic molecule that inserts itself into the plasma membrane and increases its permeability to ions. Two types are distinguished: mobile ion transporters and channel-forming ionophores (ion channels). They are not coupled to an energy source, so ion transport can only occur down their chemiosmotic concentration gradient (passive transport facilitated by a concentration gradient). The ionophore is a lipid-soluble chemical agent that helps hydrophilic ions move through the hydrophobic interior of the lipid bilayer.

[0014] Zinc: Zinc is one of the trace elements essential for humans. Zinc is found primarily in foods of animal origin such as meat, liver, eggs, seafood, milk, and dairy products. However, some foods of plant origin, such as whole grains and legumes, also contain zinc. In this invention, zinc refers to all possible forms usable by those skilled in the art and authorized for use in human and animal food, such as zinc gluconate, zinc ascorbate, zinc pidolate, and zinc orotate.

[0015] The present invention relates to a new therapeutic use of zinc associated with zinc ionophores, magnesium, vitamin B6, vitamin D and usable to block the production of peptides by ribosomes during viral, bacterial infections and in cancerous conditions.

[0016] According to the American Cancer Society, cancer is not a single disease. The term cancer encompasses more than 200 diseases, all characterized by the uncontrolled proliferation of cells. Ignoring the body's stop signal, malignant cells multiply to form tumors in organs and tissues or, in the case of blood cancers, displace normal cells from the bloodstream and bone marrow.

[0017] In a healthy body, cells grow and divide in a controlled and orderly manner to replace those that have aged or been damaged and that die by design in a process called apoptosis. Cancer occurs when these natural processes fail and malfunction.

[0018] When the genetic material of a cell—DNA—is damaged, mutations can occur, potentially disrupting normal growth and division. An accumulation of mutations can transform normal cells into precancerous cells, which sometimes multiply and develop into cancerous cells. Cancer is the result of the accumulation of these cells.

[0019] Cancer is not an event, but a process that takes time, often years, to develop. The duration varies considerably and depends on the identity, order, and rate at which mutations accumulate.

[0020] Cancer is not an event, but a process that takes time, often years, to develop. The duration varies considerably and depends on the identity, order, and rate at which mutations accumulate. The stage of cancer describes the progression of the disease in the body from pre-cancer to cancer that has spread to distant organs or tissues—metastatic cancer.

[0021] Cancers are classified according to the organ or cell type from which they originate: Carcinomas (skin cancers), sarcomas (cancers of the bones, cartilage, fat, muscles, blood vessels or any other connective or supporting tissue), leukemias (cancers of the blood cells and bone marrow), lymphomas (cancers of the immune system cells and which generally appear in the lymphatic system), cancers of the central nervous system are cancers which occur in the cells of the brain and spinal cord.

[0022] The applicant fortuitously observed that administering the composition according to the invention, under the name Biodefensine, to individuals with benign prostate cancer could not only halt the progression of the disease, but also induce a slow remission. This observation was also made in individuals infected with viruses.

[0023] Example of the composition of Biodefensin 1 for a 560 mg capsule:

[0024] Pyridoxine (vitamin B6): 10 mg,

[0025] Cholecalciferol: 25 mg (Vit. D3: 0.075 mg)

[0026] Zinc gluconate 225 mg containing 30 mg zinc

[0027] Magnesium gluconate 200 mg containing 11 mg of magnesium

[0028] Hibiscus sabdariffa (100 mg) used here as an excipient promoting intestinal absorption of the active ingredients.

[0029] According to the invention, the composition can be used to combat viral infections. The applicant fortuitously discovered that the use of the composition according to the invention during viral infections had a favorable clinical benefit for patients, with a halt in the progression of the infection and a gradual disappearance of symptoms.

[0030] According to the invention, the composition can also be used for cancers. The applicant fortuitously discovered that the use of the composition according to the invention had a favorable clinical benefit for patients. Pharmaceutical forms

[0031] According to the invention, the composition can be presented in the form of tablets, capsules, granules, syrup, oral solution or any other forms known to those skilled in the art comprising zinc associated with at least one zinc ionophore, magnesium, vitamin B6, vitamin D.

[0032] Those skilled in the art are familiar with and use various excipients as binders or lubricants in the manufacture of powders, granules, or other preparations. Examples of excipients that may be used according to the invention include: lactose, starch, dextrin, calcium phosphate, calcium carbonate, natural or synthetic aluminum silicate, magnesium oxide, hydrated aluminum hydroxide, magnesium stearate, sodium bicarbonate, and rice starch. Other excipients not mentioned above but which are also suitable are described in "Remington's Pharmaceutical Sciences" by E.W. Martin and may be used according to the invention.

[0033] In these various formulations, and for example those mentioned above, the composition may also be presented as a powder for dilution or as a syrup. This powder may contain only the active ingredients

[0034] The aim of the invention is therefore to propose a new pharmaceutical and / or dietary composition as an antibacterial (antimicrobial), antiviral and anticancer agent.

[0035] The applicant succeeds in ensuring that the administration of an effective amount of the mixture according to the composition of the invention induces a blockage of peptide synthesis by the ribosome. Applications

[0036] Pharmaceutical or dietary composition containing zinc combined with at least zinc ionophore, magnesium, vitamin B6, vitamin D and usable in particular as: • Composition, to block the production of peptides by ribosomes. • Antiviral, anticancer and antibacterial drug. • Dietary supplement. • Dietary and / or pharmaceutical product presented in the form of capsules, tablets, syrup, powder for syrup. • Composition according to the invention presented in the form of: capsules, tablets, syrup, powder for syrup.

Claims

Demands

1. Pharmaceutical or dietary composition containing zinc associated with at least one zinc ionophore, magnesium, vitamin B6 and vitamin D, characterized in that it is intended to block the production of peptides by ribosomes, particularly during viral, bacterial infections or in cancerous conditions.

2. Composition according to claim 1, characterized in that it further comprises an excipient promoting intestinal absorption of the active ingredients, such as an extract of Hibiscus sabdariffa.

3. Composition according to any one of claims 1 or 2, characterized in that it is presented in the form of capsules, tablets, syrup or powder for syrup.

4. Composition according to any one of the preceding claims, characterized in that it is intended for antiviral use.

5. Composition according to any one of claims 1 to 3, characterized in that it is intended for antibacterial use.

6. Composition according to any one of claims 1 to 3, characterized in that it is intended for anticancer use.

7. Composition according to any one of the preceding claims, characterized in that it is intended for preventive use against viral or bacterial infections.