Substituted imidazole derivative, intermediate, preparation method therefor and use thereof

Substituted imidazole derivatives and their preparations address the lack of efficacy in existing pharmaceutical compounds by providing improved therapeutic effects and specificity.

HK40134861APending Publication Date: 2026-07-10NHWA PHARMA CORPORATION
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Patent Information

Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
NHWA PHARMA CORPORATION
Filing Date
2026-06-03
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Existing pharmaceutical compounds for treating certain diseases lack efficacy and specificity, necessitating the development of novel substituted imidazole derivatives with improved pharmacological properties.

Method used

Development of substituted imidazole derivatives and their pharmaceutically acceptable salts, stereoisomers, and compositions, along with their preparation methods, to enhance therapeutic efficacy.

Benefits of technology

The novel compounds demonstrate enhanced therapeutic effects and specificity in treating targeted diseases.

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Abstract

The invention belongs to the field of medicine, and particularly relates to a compound as shown in the following general formula (I) or pharmaceutically acceptable salt, stereoisomer, tautomer, a composition containing the compound, an intermediate, a preparation method and application in the field of medicine.
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Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480041156.6 (22) Application Date 2024.06.18 (66) Domestic Priority Data 202310724980.9 2023.06.19 CN 202410149322.6 2024.02.02 CN (85) PCT International Application Entering National Phase Date 2025.12.19 (86) PCT International Application Application Data PCT / CN2024 / 099712 2024.06.18 (87) PCT International Application Publication Data WO2024 / 260319 ZH 2024.12.26 (71) Applicant Jiangsu Enhua Pharmaceutical Co., Ltd. Address 221000 No. 18 Yangshan Road, Economic and Technological Development Zone, Xuzhou City, Jiangsu Province (72) Inventors: Sun Qingdi, Dou Fei, Xu Xiangqing, Lu Aijun, Ma Zhen, Li Xuewei, Miao Shenmei, Zhan Biao, Wang Dongli, Jing Peng (74) Patent Agency: Beijing Tangsong Yongxin Intellectual Property Agency Co., Ltd. 11755 Patent Attorney: Liu Wei (51) Int.Cl. C07D 409 / 06 (2006.01) C07D 233 / 64 (2006.01) C07D 405 / 06 (2006.01) C07C 13 / 44 (2006.01) C07C 13 / 465 (2006.01) C07C 13 / 48 (2006.01) A61K 31 / 381 (2006.01) A61K 31 / 382 (2006.01) A61K 31 / 4178(2006.01) A61P 25 / 04(2006.01) A61P 25 / 20(2006.01) (54) Invention Title: A Substituted Imidazole Derivative, Intermediate, Preparation Method and Application Thereof (57) Abstract: This invention belongs to the pharmaceutical field, specifically relating to compounds or pharmaceutically acceptable salts, stereoisomers, tautomers and compositions containing the compounds shown in general formula (I) below, intermediates, preparation methods and applications in the pharmaceutical field. CN 121511240 A 2026.02.10 CN 1 21 51 12 40 A