Method for preparing orelabrutinib, and intermediate compound thereof

A simple and cost-effective method for preparing orelabrutinib intermediates addresses the complexity and environmental concerns of existing methods, enabling high-yield industrial production.

HK40134872APending Publication Date: 2026-07-10BEIJING INNOCARE PHARMA TECH CO LTD
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Patent Information

Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
BEIJING INNOCARE PHARMA TECH CO LTD
Filing Date
2026-06-04
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Existing methods for preparing orelabrutinib and its intermediate compounds are complex, costly, and not environmentally friendly, making them unsuitable for large-scale industrial production.

Method used

A method for preparing 6-(1-acryloylpiperidin-4-yl)-2-(phenoxyphenyl)pyridine-3-carboxamide using a simple route with cheap and readily available raw materials under mild conditions, resulting in high product yield and reduced production costs, suitable for industrial-scale production.

Benefits of technology

The method provides a cost-effective and environmentally friendly process for producing orelabrutinib intermediates with high yield, facilitating large-scale production.

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Abstract

The invention relates to a preparation method of obrutinib and an intermediate compound thereof. In particular to a preparation method of 6-(1-acryloyl piperidine-4-yl)-2-(phenoxy phenyl) pyridine-3-formamide and an intermediate compound of 6-(1-acryloyl piperidine-4-yl)-2-(phenoxy phenyl) pyridine-3-formamide. The preparation method has the characteristics of simple route, cheap and easily available raw materials, mild conditions, high product yield and the like, can greatly reduce the production cost, is environment-friendly, and is easy for industrial large-scale production.
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Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480048904.3 (22) Application Date 2024.07.29 (66) Domestic Priority Data 202310952107.5 2023.07.31 CN (85) PCT International Application Entering National Phase Date 2026.01.23 (86) PCT International Application Application Data PCT / CN2024 / 108085 2024.07.29 (87) PCT International Application Publication Data WO2025 / 026261 ZH 2025.02.06 (71) Applicant Beijing Nuocheng Jianhua Pharmaceutical Technology Co., Ltd. Address 102206 Building 8, Zone 1, No. 8, Life Park Road, Science and Technology Park, Changping District, Beijing (72) Inventors: Chen Xiangyang, Jiang Zhengguo, Jian Weilin (74) Patent Agency: Shanghai Patent & Trademark Agency Co., Ltd. 31100 Patent Attorneys: Fan Yunfei, Yang Yun (51) Int.Cl. C07D 401 / 04 (2006.01) C07D 211 / 00 (2006.01) (54) Invention Title: Method for preparing orelabrutinib and intermediate compound thereof (57) Abstract: A method for preparing orelabrutinib and intermediate compound thereof. Specifically, it relates to a method for preparing 6-(1-acryloylpiperidin-4-yl)-2-(phenoxyphenyl)pyridine-3-carboxamide and intermediate compound thereof. The preparation method has the characteristics of simple route, cheap and readily available raw materials, mild conditions, and high product yield, which can significantly reduce production costs, is environmentally friendly, and is easy to carry out industrial-scale production. CN 121620512 A 2026.03.06 CN 1 21 62 05 12 A