GLP-1 / GIP dual targeting polypeptides and fusion proteins and their applications
JP2024532503A5Pending Publication Date: 2025-08-14SUNSHINE LAKE PHARMA CO LTD
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Patent Information
- Application Number
- JP2024514046
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2021-09-02
- Filing Date
- 2022-09-01
- Publication Date
- 2025-08-14
AI Technical Summary
Technical Problem
Current single-target drugs for conditions like diabetes and obesity, such as GLP-1 and GIP receptor agonists, have limited effectiveness and can cause side effects, failing to meet clinical demands for comprehensive metabolic regulation.
Method used
Development of a single molecule GLP-1/GIP dual receptor agonist that activates both GLP-1 and GIP receptors through mutated polypeptides fused with an Fc fragment, enhancing weight loss and blood glucose regulation.
Benefits of technology
The GLP-1/GIP dual receptor agonist effectively controls blood glucose levels and reduces body weight by simultaneously activating both receptors, offering improved therapeutic efficacy over single-target drugs.
✦ Generated by Eureka AI based on patent content.
Abstract
The amino acid sequence: X1X2X3GTFX4SDYSX5X6X7X8X9X 10 X 11 X 12 X 13 X 14 FX 15 X 16 WLX 17 X 18 X 19 wherein X1 is Y or H, X2 is A or G or S, X3 is E or Q, X4 is I or T, X5 is I or K, X6 is A or Y or L or I, X7 is M or L, X8 is D or E, X9 is K or E, and X 10 is I or Q or K or E or L, and X 11 is H, A or R, and X 12 is A, Q, or V, and X 13 is K or Q or R or H, and X 14 is D or E or A or L, and X 15 is V or I, and X 16 is N or E or D or Q, and X 17 is L or I or K or V, and X 18 is A or E or K, and X 19 is Q or G, and X1 to X 13 X1 is Y, X2 is A, X3 is E, X4 is I, X5 is I, X6 is A, X7 is M, X8 is D, X9 is K, and X 10 is I and X 11 is H and X 12 is Q and X 13 is Q and X 14 is D and X 15 is V and X 16 is N and X 17 is L and X 18 is A and X 19 does not simultaneously satisfy Q. The GLP-1 / GIP dual targeting polypeptide can effectively reduce body weight and blood sugar level.
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