Chemical libraries encoded in oligonucleotides

The system addresses limitations in high-throughput drug screening by using picowells with bead-bound compounds and DNA barcodes for rapid compound identification and cellular analysis, improving target discovery and diagnostics.

JP2026062913APending Publication Date: 2026-04-10PLEXIUM INC
0 Cites 0 Cited by

Patent Information

Application Number
JP2026000271
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2017-09-25
Filing Date
2026-01-05
Publication Date
2026-04-10

AI Technical Summary

Technical Problem

Current high-throughput drug screening methods are limited by the need for pre-selected targets, inefficiencies in target-based selection, and the difficulty in screening compounds against entire organisms, leading to low throughput and technical limitations in combining different cell models with drug candidates.

Method used

A system utilizing picowells with bead-bound compounds and DNA barcodes for high-throughput screening, allowing for dose-controlled perturbation of cells and analysis of cellular changes through RNA and protein profiling, using DNA barcodes to identify compounds and facilitate rapid screening.

Benefits of technology

Enables efficient, high-throughput screening of compounds for biological activity, overcoming limitations of traditional methods by allowing rapid identification and analysis of compound effects on cells, enhancing target discovery and diagnostics.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

We provide a system for screening compounds. [Solution] This application provides beads with covalently attached compounds and covalently attached DNA barcodes, as well as methods for using such beads. The beads have many substantially identical copies of compounds and many substantially identical copies of DNA barcodes. The compounds consist of one or more chemical monomers, and the DNA barcodes take the form of barcode modules, each module enabling the identification of corresponding and corresponding chemical monomers. The nucleic acid barcodes may have a chain-like or orthogonal structure. Methods for sequencing bead-bound nucleic acid barcodes, methods for cleaving compounds from beads, and methods for evaluating the biological activity of released compounds are provided.
Need to check novelty before this filing date? Find Prior Art