Metal organic framework and method for producing the same

The spray-drying method produces spherical, hollow CD-MOFs with enhanced encapsulation capacity and reduced environmental footprint, addressing inefficiencies in conventional production methods and making them suitable for pulmonary formulations.

JP7777820B2Active Publication Date: 2025-12-01KANSAI UNIVERSITY +1
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Patent Information

Application Number
JP2022071673
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Filing Date
2022-04-25
Publication Date
2025-12-01
Estimated Expiration
2042-04-25

AI Technical Summary

Technical Problem

Conventional methods for producing cyclodextrin metal-organic frameworks (CD-MOFs) are inefficient, time-consuming, and environmentally burdensome, and the resulting frameworks are unsuitable for pulmonary formulations due to high density, polyhedral shape, and large particle size, limiting their ability to encapsulate large pharmacologically active substances.

Method used

A spray-drying method is employed to produce cyclodextrin metal-organic frameworks in the form of spherical hollow microparticles, with controlled particle size and porosity, allowing encapsulation of pharmacologically active substances, and reducing the use of organic solvents.

Benefits of technology

The method yields CD-MOFs with smaller particle sizes, higher encapsulation capacity, and reduced environmental impact, enabling efficient production in a shorter time with improved inhalation properties for pulmonary administration.

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Abstract

To provide a cyclodextrin metal-organic framework that can be produced without requiring a prolonged duration or an excessive amount of organic solvents, and has an increased content of pharmacologically active substance, and a method for producing the same.SOLUTION: A cyclodextrin metal-organic framework includes cyclodextrin and alkali metal and is in the form of spherical and hollow fine particles.SELECTED DRAWING: None
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