Conjugate containing detectable portion
A conjugate with a quinone methide analogue precursor amplifies signals at the target site in biological samples, addressing background noise issues in immunohistochemistry and in situ hybridization, enhancing detection and quantification of low-abundance markers.
JP7848186B2Active Publication Date: 2026-04-20VENTANA MEDICAL SYSTEMS INC
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Patent Information
- Application Number
- JP2023513314
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-08-28
- Filing Date
- 2021-08-27
- Publication Date
- 2026-04-20
- Estimated Expiration
- 2041-08-27
AI Technical Summary
Technical Problem
Existing methods for signal amplification in immunohistochemistry and in situ hybridization often result in increased background signals, obscuring faint but clinically important signals, hindering accurate detection and quantification of low-abundance cellular markers.
Method used
The use of a conjugate containing a quinone methide analogue precursor and a detectable label, which forms a reactive quinone methide analogue proximal to the target in the biological sample, allowing for signal amplification without significant background noise.
Benefits of technology
Enhances signal detection and quantification of low-abundance targets by amplifying signals specifically at the target site, reducing background noise and improving diagnostic accuracy.
✦ Generated by Eureka AI based on patent content.
Abstract
Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have narrow wavelengths and are suitable for multiplexing. Also disclosed are methods for labeling one or more targets in a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.
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