Implantable electrode, stimulator and control method therefor, electronic device, and storage medium

Abstract

Disclosed are an implantable electrode, a stimulator and a control method therefor, an electronic device, and a storage medium. The implantable electrode comprises: a control module, the control module being configured to receive a gating instruction from a pulse generator and generate a switch control signal; an array switch, the array switch being configured to establish multiple gating channels according to the switch control signal; an electrode array module, the electrode array module comprising multiple contacts, each contact being configured to deliver electrical stimulation to a tissue in a patient via the gating channels established by the array switch, or collect physiological signals from a tissue in a patient. The switch control signal is used to isolate the stimulation contacts from the collection contacts.

Description

Implantable electrode, stimulator, control method thereof, electronic device, and storage medium

[0001] This application claims priority to the Chinese patent application filed with the China Patent Office on November 6, 2023, with application number 202311461723.7, the entire contents of which are incorporated by reference into this application. Technical Field

[0002] The present application relates to the technical field of implantable medical devices, for example, to implantable electrodes, stimulators and control methods thereof, electronic devices and computer-readable storage media. Background Art

[0003] A stimulator is a type of implantable medical device that includes an (implantable) pulse generator, extension wires and electrodes, and can provide patients with parameter-controlled, refined electrical stimulation therapy.

[0004] The electrodes contain multiple contacts. To achieve real-time closed-loop stimulation, these contacts must not only perform electrical stimulation but also acquire signals. In other words, the electrodes serve as the vehicle for both electrical stimulation and signal acquisition. Generally speaking, the amplitude of the acquired signal is on the order of microvolts (μV), while the amplitude of the electrical stimulation is on the order of volts (V). This difference in magnitude makes the acquired signal susceptible to interference from the electrical stimulation, affecting the interpretation of the acquired signal.

[0005] Summary of the Invention

[0006] The present application provides an implantable electrode, a stimulator and a control method thereof, an electronic device and a computer-readable storage medium to meet the needs of practical applications.

[0007] The present application provides an implantable electrode, comprising:

[0008] a control module, the control module being configured to receive a gating instruction of the pulse generator and generate a switch control signal;

[0009] an array switch, the array switch being configured to establish a multiplexed access channel according to the switch control signal;

[0010] an electrode array module, the electrode array module comprising a plurality of contacts, each contact being configured to deliver electrical stimulation to a patient's internal tissue through a strobe channel established by the array switch and serving as a stimulation contact, or to collect physiological signals from the patient's internal tissue and serving as a collection contact;

[0011] The switch control signal is used to isolate the stimulation contact for delivering electrical stimulation from the collection contact for collecting physiological signals.

[0012] In some possible implementations, the switch control signal includes a high-level signal and a low-level signal, the high-level signal is used to enable a channel of the array switch, and the low-level signal is used to disconnect the channel of the array switch.

[0013] In some possible implementations, the array switch includes multiple switch modules:

[0014] Each switch module includes:

[0015] an insulating layer, wherein the insulating layer is configured to form a receiving cavity;

[0016] a switch unit, the switch unit being disposed in the accommodating cavity formed by the insulating layer, the switch unit being configured to establish a gating channel for a contact corresponding to the switch control signal according to the switch control signal;

[0017] A conductive layer is coated on the outer surface of the insulating layer and is configured to be grounded through a wire to achieve shielding against electric field interference and / or electromagnetic interference.

[0018] In some possible implementations, the electrode array module is a Utah electrode.

[0019] In some possible implementations, the physiological signal is a local field potential signal.

[0020] In a second aspect, the present application provides a stimulator, comprising:

[0021] The implantable electrode according to any one of the above items, wherein the implantable electrode is configured to deliver electrical stimulation to the patient's internal tissue and collect physiological signals;

[0022] A pulse generator is electrically connected to the implantable electrode, or the pulse generator is electrically connected to the implantable electrode through an extension wire, and the pulse generator is configured to analyze the physiological signal and generate the electrical stimulation.

[0023] In some possible implementations, the pulse generator includes:

[0024] a stimulation contact determination module, configured to use at least one contact in the electrode array module as a stimulation contact according to treatment information of the patient, wherein the stimulation contact is configured to deliver electrical stimulation to an in vivo tissue of the patient;

[0025] an isolation contact point acquisition module configured to acquire, for each stimulation contact point, a plurality of contacts satisfying a preset distance and / or preset position relationship with the stimulation contact point as a center point as isolation contacts;

[0026] The acquisition contact determination module is configured to select contacts other than stimulation contacts and isolation contacts as acquisition contacts based on the treatment information; and when the stimulation contacts deliver electrical stimulation to the patient's internal tissues, use the acquisition contacts to acquire physiological signals from the patient's internal tissues and use the acquired physiological signals as acquisition information.

[0027] In some possible implementations, the treatment information includes preset parameters corresponding to each stimulation contact, where the preset parameters are used to indicate a distance relationship or a position relationship between the stimulation contact and the isolation contact corresponding to the stimulation contact.

[0028] In some possible implementations, the isolation contact acquisition module includes:

[0029] a parameter prediction unit, configured to input the stimulation parameters corresponding to the stimulation contacts into a prediction model to obtain reference preset parameters corresponding to the stimulation contacts;

[0030] a similarity determination unit configured to obtain a first similarity between the reference preset parameter and the preset parameter;

[0031] a first contact point acquisition unit configured to, when the first similarity is less than a preset similarity, perform an eight-neighborhood search on the stimulation contact using the preset parameters to acquire an isolated contact;

[0032] The second contact acquisition unit is configured to update the preset parameters using the reference preset parameters when the first similarity is not less than the preset similarity, and perform an eight-neighborhood search on the stimulation contact using the updated preset parameters to obtain an isolated contact.

[0033] In some possible implementations, the pulse generator further includes:

[0034] a number counting module configured to, when the first similarity is less than a preset similarity, increase the number of statistics by one and determine whether the number of statistics is greater than a preset number of statistics;

[0035] The risk warning module is configured to generate risk warning information and clear the statistical number when the statistical number is greater than the preset statistical number.

[0036] In some possible implementations, the pulse generator further includes:

[0037] The recommended contact acquisition module is configured to determine the score value of each stimulation contact based on the stimulation parameters and collection information corresponding to each stimulation contact, and use the stimulation contact with the highest score as the recommended stimulation contact.

[0038] In a third aspect, the present application provides a method for controlling a stimulator, the method being applied to any of the stimulators described above, the method comprising:

[0039] using at least one contact in the electrode array module as a stimulation contact according to treatment information of the patient, wherein the stimulation contact is used to deliver electrical stimulation to tissue in the body of the patient;

[0040] For each stimulation contact, a plurality of contacts satisfying a preset distance and / or preset position relationship are obtained with the stimulation contact as a center point as isolation contacts;

[0041] According to the treatment information, a contact is selected from contacts other than the stimulation contacts and the isolation contacts and used as a collection contact; and when the stimulation contact delivers electrical stimulation to the patient's internal tissue, the collection contact is used to collect physiological signals from the patient's internal tissue and the collected physiological signals are used as collection information.

[0042] In some possible implementations, the treatment information includes preset parameters corresponding to each stimulation contact, where the preset parameters are used to indicate a distance relationship or a position relationship between the stimulation contact and its corresponding isolation contact.

[0043] In some possible implementations, for each stimulation contact, performing an eight-neighborhood search with the stimulation contact as a center point to obtain multiple contacts that satisfy a preset distance and / or preset position relationship as isolated contacts includes:

[0044] Inputting the stimulation parameters corresponding to the stimulation contacts into a prediction model to obtain reference preset parameters corresponding to the stimulation contacts;

[0045] Obtaining a first similarity between the reference preset parameter and the preset parameter;

[0046] When the first similarity is less than a preset similarity, performing an eight-neighborhood search on the stimulation contact using the preset parameters to obtain an isolated contact;

[0047] When the first similarity is not less than a preset similarity, the preset parameters are updated using the reference preset parameters, and an eight-neighborhood search is performed on the stimulation contact using the updated preset parameters to obtain an isolated contact.

[0048] In some possible implementations, the treatment information includes preset parameters corresponding to each stimulation contact, where the preset parameters are used to indicate the distance relationship or position relationship between the stimulation contact and its corresponding isolation contact.

[0049] In some possible implementations, for each stimulation contact, obtaining a plurality of contacts that satisfy a preset distance and / or preset position relationship with the stimulation contact as a center point as isolated contacts includes:

[0050] Inputting the stimulation parameters corresponding to the stimulation contacts into a prediction model to obtain reference preset parameters corresponding to the stimulation contacts;

[0051] Obtaining a first similarity between the reference preset parameter and the preset parameter;

[0052] When the first similarity is less than a preset similarity, performing an eight-neighborhood search on the stimulation contact using the preset parameters to obtain an isolated contact;

[0053] When the first similarity is not less than a preset similarity, the preset parameters are updated using the reference preset parameters, and an eight-neighborhood search is performed on the stimulation contact using the updated preset parameters to obtain an isolated contact.

[0054] In some possible implementations, the method further includes:

[0055] When the first similarity is less than a preset similarity, adding one to the statistical number and determining whether the statistical number is greater than a preset statistical number;

[0056] When the statistical number is greater than the preset statistical number, risk warning information is generated and the statistical number is cleared.

[0057] In some possible implementations, the method further includes:

[0058] According to the stimulation parameters and the collected information corresponding to each stimulation contact, a score value of each stimulation contact is determined, and the stimulation contact with the highest score value is used as the recommended stimulation contact.

[0059] In a fourth aspect, the present application provides an electronic device, comprising a memory and a processor, wherein the memory stores a computer program, and the processor implements any one of the above methods when executing the computer program.

[0060] In a fifth aspect, the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by at least one processor, it implements any of the above methods.

[0061] In a sixth aspect, the present application provides a computer program product, which includes a computer program, and when the computer program is executed by at least one processor, it implements any of the above methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0062] FIG1 is a structural block diagram of an implantable electrode provided in an embodiment of the present application.

[0063] FIG2 is a partial cross-sectional schematic diagram of a switch module provided in an embodiment of the present application.

[0064] FIG3 is a schematic structural diagram of an implantable electrode provided in an embodiment of the present application.

[0065] FIG4 is a schematic diagram of the positions of contacts of an electrode array module provided in an embodiment of the present application.

[0066] FIG5 is a flow chart of a control method of a stimulator provided in an embodiment of the present application.

[0067] FIG6 is a schematic diagram of a process for obtaining an isolation contact provided by an embodiment of the present application.

[0068] FIG7 is a flow chart of another control method of a stimulator provided in an embodiment of the present application.

[0069] FIG8A is a structural block diagram of a stimulator provided in an embodiment of the present application.

[0070] FIG8B is a structural block diagram of another stimulator provided in an embodiment of the present application.

[0071] FIG9 is a structural block diagram of an electronic device provided in an embodiment of the present application.

[0072] FIG10 is a schematic diagram of the structure of a computer program product provided in an embodiment of the present application. DETAILED DESCRIPTION

[0073] The technical solutions in this application will be described below in conjunction with the accompanying drawings and implementation methods of this application. Under the premise of no conflict, the multiple implementation methods or multiple technical features described below can be arbitrarily combined to form a new implementation method.

[0074] In the examples of this application, words such as "exemplary" or "for example" are used to indicate examples, illustrations, or descriptions. Any embodiment or design described as "exemplary" or "for example" in the examples of this application should not be interpreted as being more preferred or more advantageous than other embodiments or designs. Rather, the use of words such as "exemplary" or "for example" is intended to present related concepts in a certain way.

[0075] The first, second, etc. descriptions appearing in the embodiments of the present application are only used for illustration and distinction of the description objects. There is no order, nor does it indicate a special limitation on the quantity in the embodiments of the present application, and cannot constitute any limitation on the embodiments of the present application.

[0076] Below, one of the application fields (i.e., implantable medical devices) of the embodiments of the present application is briefly described.

[0077] Implantable medical systems include implantable neurostimulation systems, implantable cardiac stimulation systems (also known as pacemakers), implantable drug delivery systems (IDDS), and lead adapter systems. Examples of implantable neurostimulation systems include deep brain stimulation (DBS) systems, implantable cortical nerve stimulation (CNS) systems, implantable spinal cord stimulation (SCS) systems, implantable sacral nerve stimulation (SNS) systems, and implantable vagus nerve stimulation (VNS) systems.

[0078] The implantable neural electrical stimulation system includes a stimulator implanted in the patient's body (i.e., an implantable neural stimulator) and a programmable device disposed outside the patient's body. In other words, the stimulator is a medical device, or in other words, the medical device includes a stimulator. The relevant neuromodulation technology mainly involves implanting electrodes (electrodes, for example, in the form of electrode wires) in specific locations (i.e., target points) of the tissues of an organism through stereotactic surgery, sending discharge pulses to the target points through the electrodes, and regulating the electrical activity and function of the corresponding neural structures and networks, thereby improving symptoms and alleviating pain.

[0079] As an example, DBS includes an implantable pulse generator (IPG), an extension wire, and electrodes, wherein the IPG is connected to the electrodes via the extension wire. The IPG is implanted in the patient's body, for example, in the patient's chest or other internal body parts.

[0080] As another example, DBS includes an IPG and electrodes, with the IPG directly connected to the electrodes. The IPG is implanted in the patient's head, for example, by making a groove in the patient's skull and then installing the IPG in the groove. In this case, the IPG may not protrude from the outer surface of the skull, or may partially protrude from the outer surface of the skull.

[0081] The IPG responds to program-controlled instructions sent by a program-controlled device, relying on a sealed battery and circuitry to provide controlled electrical stimulation therapy (or electrical stimulation energy) to tissues within the body. When the battery is low, it needs to be recharged, and this can be done wirelessly using an electromagnetic induction coil, charging through the skin or other epidermal tissue. The IPG delivers one or more controllable, specific electrical stimulations to specific areas of tissue within the body through electrodes.

[0082] In some embodiments, the extension lead is used in conjunction with the IPG as a transmission medium for electrical stimulation, transmitting the electrical stimulation generated by the IPG to the electrodes.

[0083] In some embodiments, electrical stimulation can be delivered in the form of a pulsed signal or a non-pulsed signal. For example, electrical stimulation can be delivered as a signal having a variety of waveform shapes, frequencies, and amplitudes. Thus, electrical stimulation in the form of a non-pulsed signal can be a continuous signal, which can have a sinusoidal waveform or other continuous waveform.

[0084] The embodiments of the present application do not limit the types of diseases that can be treated with DBS, SCS, sacral nerve stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation. The types of diseases that DBS can be used to treat or manage include: spastic disorders (e.g., epilepsy), pain, migraine, mental illness (e.g., Major Depressive Disorder (MDD)), bipolar disorder, anxiety, post-traumatic stress disorder, mild depression, obsessive-compulsive disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, mobility disorders (e.g., essential tremor or Parkinson's disease), Huntington's disease, Alzheimer's disease, drug addiction, autism, or other neurological or psychiatric diseases and injuries.

[0085] In an embodiment of the present application, when a programmable connection is established between a programmable device and a stimulator, the programmable device can be used to adjust one or more stimulation parameters of the stimulator (or one or more stimulation parameters of a pulse generator, different stimulation parameters correspond to different electrical stimulations), or the stimulator can be used to sense the patient's electrophysiological activities to collect electrophysiological signals, and the collected electrophysiological signals can be used to continue to adjust the stimulation parameters of the stimulator to achieve closed-loop control (or adaptive adjustment) of the stimulation parameters.

[0086] Stimulation parameters may include at least one of the following: electrode contact identification for delivering electrical stimulation (for example, electrode contact #2 and electrode contact #3), frequency (for example, the number of electrical stimulation pulse signals within a unit time of 1s, in Hz), pulse width (duration of each pulse, in μs), amplitude (generally expressed in voltage, that is, the intensity of each pulse, in V), timing (for example, it can be continuous or burst, and burst refers to a discontinuous timing behavior composed of multiple processes), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode and cyclic stimulation mode), upper and lower limits controlled by the doctor (the range that the doctor can adjust) and upper and lower limits controlled by the patient (the range that the patient can adjust independently).

[0087] In some embodiments, at least one stimulation parameter of the stimulator can be adjusted in current mode or voltage mode.

[0088] Programmable devices may include doctor-controlled devices (i.e., programmable devices used by doctors) and / or patient-controlled devices (i.e., programmable devices used by patients). Doctor-controlled devices are, for example, tablet computers, laptop computers, desktop computers, mobile phones, and other smart terminal devices equipped with programmable software. Patient-controlled devices are, for example, tablet computers, laptop computers, desktop computers, mobile phones, and other smart terminal devices equipped with programmable software. Patient-controlled devices may also be other electronic devices with programmable functions (e.g., chargers with programmable functions, electrophysiological data acquisition devices, etc.).

[0089] The embodiments of the present application do not restrict the data interaction between the doctor-controlled device and the stimulator. When the doctor performs remote programming, the doctor-controlled device can exchange data with the stimulator through the server and the patient-controlled device. When the doctor performs offline programming with the patient face-to-face, the doctor-controlled device can exchange data with the stimulator through the patient-controlled device, or directly with the stimulator.

[0090] In some embodiments, the patient programmable device may include a host (communicating with a server) and a slave (communicating with a stimulator), and the host and the slave are communicatively connected. The doctor programmable device may exchange data with the server via a third-generation mobile communication technology / fourth-generation mobile communication technology / fifth-generation mobile communication technology (3G / 4G / 5G) network, the server may exchange data with the host via a 3G / 4G / 5G network, the host may exchange data with the slave via a Bluetooth protocol / Wireless Fidelity (WIFI) protocol / Universal Serial Bus (USB) protocol, the slave may exchange data with the stimulator via a 401MHz-406MHz operating frequency band / 2.4GHz-2.48GHz operating frequency band, and the doctor programmable device may directly exchange data with the stimulator via a 401MHz-406MHz operating frequency band / 2.4GHz-2.48GHz operating frequency band.

[0091] In related technologies, considering the use of electrode contacts to release stimulation and collect signals, in order to achieve closed-loop control of the stimulator, the collected signals are mainly processed as follows:

[0092] Filtering, using filters to select signals within a specific frequency range to filter out noise at other frequencies;

[0093] Use noise reduction algorithms, such as wavelet transform and independent component analysis (ICA), to separate the useful components and noise components in the signal.

[0094] However, the above processing method does not solve the problem from the source, that is, from the process of signal acquisition. Based on this, the present application provides an implantable electrode, a stimulator and its control method, and a computer-readable storage medium, which realize electrical stimulation and physiological signal acquisition in the patient's body through a control module, an array switch and an electrode array module, and establish isolation between electrical stimulation and signal acquisition by controlling the switch control signal, thereby reducing the interference of electrical stimulation on acquisition from the source, thereby improving the accuracy of the closed-loop control of the stimulator.

[0095] The following will describe an implantable electrode for a stimulator, a control method for the stimulator, and the stimulator.

[0096] Implantable Electrode Embodiments.

[0097] 1 to 4 , FIG1 is a structural block diagram of an implantable electrode provided in an embodiment of the present application.

[0098] This embodiment provides an implantable electrode, comprising:

[0099] A control module 10, wherein the control module 10 is configured to receive a gating instruction of a pulse generator and generate a switch control signal;

[0100] an array switch 20, wherein the array switch 20 is configured to establish a multiplexed access channel according to the switch control signal;

[0101] an electrode array module 30, the electrode array module 30 comprising a plurality of contacts 31, each contact 31 being configured to deliver electrical stimulation to the patient's internal tissue via a strobe channel established by the array switch 20 and function as a stimulation contact, or to collect physiological signals from the patient's internal tissue and function as a collection contact;

[0102] The switch control signal is used to isolate the stimulation contact for delivering electrical stimulation from the collection contact for collecting physiological signals at the same time.

[0103] Thus, through the control of the switch control signal, physical isolation is established between electrical stimulation and signal acquisition, which reduces the interference of electrical stimulation on the acquisition signal and improves the accuracy of the acquired data. By selectively activating specific electrode contacts, specific stimulation areas can be located and treated, thereby improving the treatment effect. The electrode array module (equivalent to the electrodes mentioned above) is not only configured to perform electrical stimulation, but also to collect the patient's physiological signals, which can be used by the user to monitor the patient's physiological state in real time and make necessary adjustments. In summary, electrical stimulation and physiological signal acquisition are simultaneously achieved in the patient's body through the control module, array switch and electrode array module, and the interference of electrical stimulation on the acquisition is reduced.

[0104] Physiological signals can include neuronal signals and / or local field potential signals. Neuronal signals are electrical signals generated by neurons and used to transmit information between neurons. Neuronal signals typically occur in the form of pulses known as action potentials. The acquisition and analysis of neuronal signals can provide information about neuronal activity, thereby helping to understand the functions and abnormalities of the nervous system.

[0105] Local field potential signals refer to changes in electrical potential generated by the electrical activity of surrounding neurons. The acquisition of local field potential signals can provide information about neural network activity and the behavior of neuronal populations. Analysis of local field potential signals can reveal the synchronization and regulatory mechanisms of neuronal populations, as well as the electrical activity associated with specific functions. By acquiring and analyzing neuronal signals and / or local field potential signals, important information about nervous system function and disease states can be obtained, aiding in the diagnosis and treatment of neurological diseases and providing personalized closed-loop deep brain stimulation therapy.

[0106] In some embodiments, the switch control signal includes a high-level signal and a low-level signal. The high-level signal is used to enable a channel of the array switch 20 , and the low-level signal is used to disconnect a channel of the array switch 20 .

[0107] By using high- and low-level signals, the precision of controlling the channel states of the array switches is improved, ensuring connections are established when needed and disconnected when not, meeting treatment or signal acquisition requirements. This combination of high- and low-level signals enables diverse bidirectional communication for real-time closed-loop control and monitoring.

[0108] Among them, a high level indicates that the electrical signal is at a higher voltage level, and a low level indicates that the electrical signal is at a lower voltage level.

[0109] As an example, 3.3 volts is used as a high level and 0 volts is used as a low level.

[0110] As another example, a voltage between 1.65 volts and 5 volts is considered a high level, and a voltage below 1.65 volts is considered a low level.

[0111] Channeling refers to when a connection in a circuit is opened or interrupted, preventing current from flowing through it. Channeling refers to when a connection in a circuit is closed or connected, allowing current to flow freely through it.

[0112] Refer to FIG2 , which is a partial cross-sectional schematic diagram of a switch module provided in an embodiment of the present application.

[0113] In some embodiments, the array switch 20 includes a plurality of switch modules 21:

[0114] Each switch module 21 includes:

[0115] an insulating layer 210 , wherein the insulating layer 210 is configured to form a receiving cavity 211 ;

[0116] a switch unit 212, the switch unit 212 being disposed in the accommodating cavity 211 formed by the insulating layer 210, and the switch unit 212 being configured to establish a gating channel for its corresponding contact 31 according to the switch control signal;

[0117] The conductive layer 213 is coated on the outer surface of the insulating layer 210 and is configured to be grounded through a wire to achieve shielding against electric field interference and / or electromagnetic interference.

[0118] Each switch module 21 includes an insulating layer 210, which is configured to form a receiving cavity 211. A switch unit 212 is disposed within the receiving cavity 211 formed by the insulating layer 210 to establish a selection channel for the contact 31 corresponding to the switch control signal according to the switch control signal. It can be understood that by controlling the switch unit 212, the channel between the contacts 31 can be selectively connected or disconnected. The conductive layer 213 is coated on the outer surface of the insulating layer 210 and is grounded through a wire to shield electric field interference and / or electromagnetic interference through grounding. It can be considered that the presence of the conductive layer 213 helps to reduce the impact of external interference on the collected signal passing through the switch unit 212.

[0119] The insulating layer 210 may be composed of one or more of a ceramic material, a resin material, or a polymer material to achieve insulation between the switch unit 212 contained in the cavity 211 and the outside of the insulating layer 210 (e.g., the conductive layer). The conductive layer 213 may be made of a metal material, such as copper, silver, etc.; it may also be made of a carbon-based conductive material, such as graphite that can be used to prepare flexible circuit boards. The switch unit 212 is one of the basic components of the switch module 21 of the array switch 20, and is located in the insulating layer 210 and is responsible for achieving electrical connection or isolation between the contacts 31. The switch unit 212 may be in the form of different technologies and structures, such as an electronic switch, a magnetic switch, an electrochemical switch, or an optical switch.

[0120] It's generally believed that signals passing through switch unit 212 are negative-polarity electrons. By grounding conductive layer 213, the charges and magnetic fields in the space surrounding the switch module that come into contact with conductive layer 213 are directed outward (to the grounding point where the wires are connected), providing a shield against electric and electromagnetic interference. Furthermore, the shielding layer can block or mitigate interference from external electromagnetic or electric fields. The combination of conductive layer 213 and the shielding layer provides effective shielding and isolation.

[0121] In summary, on the premise of establishing physical isolation between electrical stimulation and signal acquisition through the control of the switch control signal, reducing the interference of electrical stimulation on the acquired signal, it is possible to further form shielding against electric field and electromagnetic interference, thereby improving the acquisition accuracy and stability.

[0122] In application, an upper connection portion is further provided between each switch module 21 and the control module 10, and a lower connection portion is further provided between each switch module 21 and the contact 31 of the electrode array module 30. The upper connection portion and the lower connection portion are respectively configured to realize electrical connection between the switch module 21 and the control module 10 and the contact 31. In some embodiments, the electrode array module 30 is a Utah electrode; and / or,

[0123] The physiological signal is a local field potential signal.

[0124] The Utah electrode can include multiple electrode contacts, and contact 31 can be configured to simultaneously collect physiological signals and perform electrical stimulation. The multi-channel function described above enables the acquisition or stimulation of different neural regions at the same time, providing more treatment options. Due to the multi-electrode layout of the Utah electrode, it can provide high-spatial-resolution signal acquisition and stimulation, thereby enabling the precise location and treatment of specific neural regions. The Utah electrode is tiny and flexible and can be implanted in the patient through minimally invasive surgery, reducing surgical trauma and recovery time. At the same time, the local field potential signal primarily reflects the physiological activity of a specific region, allowing the collected signal to more accurately reflect the state of the tissue.

[0125] Because local field potential signals encompass the activity of a large number of neurons, they provide more comprehensive information to offer insights into the overall state of the nervous system while reducing the need for complex measurements at the level of individual neurons.

[0126] Among them, the main body of the Utah electrode can be made of a silicon wafer, and the tip of the needle-shaped contact of the Utah electrode can be covered with platinum or other metal materials with good conductivity to release electrical stimulation to the tissue or collect physiological electrical signals. At the same time, the part other than the tip of the contact can be insulated by insulating materials such as polyimide.

[0127] See FIG3 , which is a schematic structural diagram of an implantable electrode provided in an embodiment of the present application.

[0128] In one application scenario, an embodiment of the present application further provides an implantable electrode, which includes: a control module, an array switch, and an electrode array module.

[0129] The control module is configured to receive a gating instruction from the pulse generator and generate a switch control signal. The switch control signal includes a high-level signal and a low-level signal. The high-level signal is used to enable a channel of the array switch, and the low-level signal is used to disconnect a channel of the array switch, thereby isolating the stimulation contact from the collection contact.

[0130] The array switch is configured to establish multiplexed access channels according to the switch control signal, and the electrode array module is a Utah electrode;

[0131] The electrode array module includes multiple contacts, each of which is configured to deliver electrical stimulation to the patient's internal tissue through a selection channel established by the array switch and serve as a stimulation contact, or to collect physiological signals from the patient's internal tissue and serve as a collection contact, where the physiological signals are local field potential signals.

[0132] Among them, the array switch can use different mechanisms to turn on or off, and this application does not limit it. The array switch includes, for example, multiple electronic switches, magnetic switches, electrochemical switches or optical switches. The electronic switch can use solid-state electronic components (such as transistors, relays, etc.) to control the opening and closing of the channel to switch the state of the channel very quickly. The magnetic switch refers to the use of a magnetic field to control the conduction or disconnection of the channel. Generally speaking, when the magnetic field is adjusted, the magnetic switch will change its state. The electrochemical switch refers to the use of an electrochemical reaction to realize the opening and closing of the channel. It contains electrolyte materials and can change the channel state by controlling the electrochemical reaction. The optical switch refers to the use of an optical signal to control the channel state. For example, the optical switch can use an optical fiber or an optical component to control the transmission or blocking of the optical signal.

[0133] As an example, refer to FIG4 , which is a schematic diagram of the positions of contacts of an electrode array module provided in an embodiment of the present application.

[0134] The contacts 31 in the electrode array module are labeled. Electrodes marked with an "×" (e.g., C3, C4, C5, D3, D5, E3, E4, and E5) are configured to represent contacts 31 corresponding to disconnected channels controlled by low-level signals. The central dot (D4) of the electrode region marked with an "×" can be a stimulation contact, configured to deliver electrical stimulation to the patient's internal tissues via the selected channel established by the array switch under high-level control. The peripheral dots (A1, A2, etc.) of the electrode region marked with an "×" can be used as collection contacts to collect physiological signals from the patient's internal tissues. When the high-level signal is used to select the array switch channel and the low-level signal is used to disconnect the array switch channel, the stimulation contact and the collection contact can be isolated.

[0135] Method embodiment.

[0136] See FIG5 , which is a flow chart of a control method for a stimulator provided in an embodiment of the present application.

[0137] The stimulator involved in this method embodiment is configured to be implanted in a patient's body and configured to simultaneously deliver electrical stimulation to the patient's internal tissue and / or collect physiological signals from the patient's internal tissue. The stimulator includes the implantable electrode of the electrode embodiment and a pulse generator. The implantable electrode is consistent with the embodiment described in the above-mentioned electrode embodiment and the technical effects achieved are consistent, and some details are not repeated here.

[0138] The control method of the stimulator includes the following steps.

[0139] Step S101: at least one contact in an electrode array module of an implantable electrode is used as a stimulation contact according to treatment information of the patient; the stimulation contact is used to deliver electrical stimulation to the patient's body tissue.

[0140] Step S102: for each stimulation contact, a plurality of contacts satisfying a preset distance and / or a preset position relationship are obtained with the stimulation contact as a center point as isolation contacts.

[0141] Step S103: Select contacts other than stimulation contacts and isolation contacts as collection contacts based on the treatment information; and when the stimulation contacts deliver electrical stimulation to the patient's internal tissues, use the collection contacts to collect physiological signals from the patient's internal tissues and use the collected physiological signals as collection information.

[0142] Thus, the pulse generator and the implantable electrode cooperate to adjust the electrical stimulation parameters according to the patient's physiological signals as feedback information to meet the patient's specific needs (i.e., personalized needs) and realize closed-loop control of the patient's electrical stimulation. By selecting isolation contacts, the unnecessary impact of stimulation on surrounding tissues can be reduced, and the risks and side effects of treatment can be reduced. The stimulation contacts, isolation contacts and acquisition contacts are determined in the above manner and then used for the execution of treatment, wherein the stimulation contacts will be used to deliver electrical stimulation to the tissue, and the acquisition contacts will be used to monitor the patient's physiological response at the same time, so as to achieve the best monitoring effect.

[0143] Among them, the treatment information includes, for example, the patient's condition, whether it is essential tremor, Parkinson's disease or other diseases. Different conditions correspond to different nuclei to be treated. According to the treatment information, one or more contacts in the electrode array module of the implantable electrode that are closest to the nucleus to be stimulated can be used as stimulation contacts. According to the treatment information, contacts are selected from contacts other than the stimulation contacts and the isolation contacts and used as collection contacts. It can be understood that the contacts closest to the stimulation contacts are selected from contacts other than the above two types of contacts as collection contacts to obtain objective feedback on the patient's condition after receiving electrical stimulation. The treatment information can also directly include the position of one or more contacts to be stimulated and the stimulation parameters corresponding to one or more contacts.

[0144] See FIG. 6 , which is a schematic diagram of a process for obtaining an isolation contact provided by an embodiment of the present application.

[0145] In some embodiments, the treatment information includes preset parameters corresponding to each stimulation contact, and the preset parameters are used to indicate the distance relationship or position relationship between the stimulation contact and its corresponding isolation contact.

[0146] For each stimulation contact, performing an eight-neighborhood search with the stimulation contact as the center point to obtain multiple contacts that meet a preset distance and / or preset position relationship as isolated contacts, including:

[0147] Step S201: input the stimulation parameters corresponding to the stimulation contacts into a prediction model to obtain reference preset parameters corresponding to the stimulation contacts.

[0148] Step S202: Obtain a first similarity between the reference preset parameter and the preset parameter.

[0149] Step S203: When the first similarity is less than a preset similarity, an eight-neighborhood search is performed on the stimulation contact using the preset parameters to obtain an isolated contact.

[0150] Step S204: When the first similarity is not less than the preset similarity, the preset parameters are updated using the reference preset parameters, and an eight-neighborhood search is performed on the stimulation contact using the updated preset parameters to obtain an isolated contact.

[0151] Therefore, the use of the eight-neighborhood search method can reduce the error in the contact selection process and improve the accuracy and reliability of treatment. If the first similarity is less than the preset similarity, it means that there is a large difference between the preset parameters of the stimulation contact and the reference preset parameters. The preset parameters are determined by the user based on prior calibration and testing, and have relatively high stability and reliability. In this case, the preset parameters of the stimulation contact are used to perform an eight-neighborhood search to obtain the isolated contact. If the first similarity is not less than the preset similarity, it means that the preset parameters of the stimulation contact are relatively close to the reference preset parameters, and then the preset parameters are updated and the updated preset parameters are selected to perform an eight-neighborhood search to obtain the isolated contact.

[0152] Among them, the eight-neighborhood search is an algorithm for finding surrounding adjacent points or elements. Its process mainly includes: determining a center point, and determining eight adjacent points around the center point. The adjacent points can be located above, below, left, right, and in four diagonal directions of the center point. Since the contacts on the electrode array module are mostly arranged in a standardized manner, using the eight-neighborhood search is more efficient. In application, other related "neighborhood"-based heuristic algorithms (neighborhood search algorithms) can also be used.

[0153] The first similarity between the reference preset parameters and the preset parameters can be obtained by quantifying the difference between the two sets of parameters into a value using a metric such as Euclidean distance, Manhattan distance, or cosine similarity, where a smaller value indicates a higher similarity. Alternatively, a correlation coefficient between the two sets of parameters can be calculated, such as the Pearson correlation coefficient or the Spearman rank correlation coefficient. The correlation coefficient indicates the degree of linear or nonlinear correlation between the two sets of parameters, and a correlation coefficient close to 1 indicates a high degree of similarity.

[0154] The prediction model can be trained based on a machine learning algorithm using training data from known stimulation parameters corresponding to stimulation contacts and corresponding reference preset parameters. After inputting the stimulation parameters into the trained prediction model, the prediction model predicts the corresponding predicted preset parameters, which serve as reference preset parameters. The prediction model can be trained or pre-trained.

[0155] In some embodiments, the prediction model training process includes:

[0156] Acquire a training set, the training set including a plurality of training data, each of the training data including a stimulation parameter and labeled data of a preset parameter corresponding to the stimulation parameter;

[0157] For each training data in the training set, perform the following processing:

[0158] Inputting the stimulation parameters in the training data into a preset deep learning model to obtain prediction data of preset parameters corresponding to the stimulation parameters;

[0159] Updating the model parameters of the deep learning model based on the prediction data and the labeled data of the preset parameters corresponding to the stimulation parameters;

[0160] Detect whether the preset training end condition is met; if so, use the trained deep learning model as the prediction model; if not, continue training the deep learning model using the next training data.

[0161] Therefore, by designing, establishing an appropriate number of neuron computing nodes and a multi-layer operation hierarchy, and selecting appropriate input and output layers, a preset deep learning model can be obtained. Through the learning and tuning of the deep learning model, a functional relationship from input to output is established. Although the functional relationship between input and output cannot be found 100%, the actual correlation relationship can be approached as much as possible. The prediction model trained in this way can obtain the corresponding output data based on the input data. It has a wide range of applications, and the calculation results are highly accurate and reliable.

[0162] In some embodiments, the method further comprises:

[0163] When the first similarity is less than a preset similarity, adding one to the statistical number and determining whether the statistical number is greater than a preset statistical number;

[0164] When the statistical number is greater than the preset statistical number, risk warning information is generated and the statistical number is cleared.

[0165] Therefore, if the first similarity is less than the preset similarity, it indicates that there is a significant difference between the preset parameters of the stimulation contact and the reference preset parameters. If the first similarity is less than the preset similarity, the number of similarity differences is recorded and a determination is made as to whether the statistical number is greater than the preset statistical number. If the statistical number is greater than the preset statistical number, a risk warning message is generated to alert the user or to prompt further action.

[0166] This embodiment does not limit the preset similarity, which may be 0.81, 0.83, 65%, 75%, 87%, 88%, 89% or 95%, for example.

[0167] Risk warning information can be sent to user devices via voice, images, or text, such as tablets, mobile phones, or programmers used by doctors and patient guardians. As an example, when the number of statistical counts reaches 10 and exceeds the preset statistical number (9 times), the risk warning information is sent via voice to the mobile phone of patient A's attending physician B. The mobile phone will automatically play a voice message saying "Patient A's stimulation treatment requires your attention" so that the doctor can be informed of the risk situation as soon as possible and take further measures.

[0168] See FIG. 7 , which is a flow chart of another control method for a stimulator provided in an embodiment of the present application.

[0169] In some embodiments, the method further comprises:

[0170] Step S104: determining a score value for each stimulation contact according to the stimulation parameters and the collected information corresponding to each stimulation contact, and taking the stimulation contact with the highest score value as the recommended stimulation contact.

[0171] Therefore, by scoring and selecting the stimulation contacts with the highest scores, users can be assisted in making treatment decisions more efficiently.

[0172] The physiological response of each stimulation contact can be used as a basis for scoring. For example, the amplitude, frequency, or phase of the physiological signal generated by the stimulation contact can be used to evaluate the effect of the stimulation, with a larger physiological response receiving a higher score.

[0173] In one application scenario, an embodiment of the present application further provides a method for controlling a stimulator, the method comprising:

[0174] At least one contact in the electrode array module of the implantable electrode is used as a stimulation contact according to the patient's treatment information; the stimulation contact is used to deliver electrical stimulation to the patient's body tissue;

[0175] For each stimulation contact, inputting the stimulation parameters corresponding to the stimulation contact into the prediction model to obtain the reference preset parameters corresponding to the stimulation contact;

[0176] Obtaining a first similarity between the reference preset parameter and the preset parameter;

[0177] When the first similarity is not less than a preset similarity, the preset parameters are updated using the reference preset parameters, and an eight-neighborhood search is performed on the stimulation contact using the updated preset parameters to obtain an isolated contact;

[0178] When the first similarity is less than the preset similarity, the preset parameters are used to perform an eight-neighborhood search on the stimulation contact to obtain an isolated contact; the statistical number is increased by one and it is determined whether the statistical number is greater than the preset statistical number. When the statistical number is greater than the preset statistical number, risk warning information is generated and the statistical number is cleared.

[0179] According to the treatment information, a contact is selected from contacts other than the stimulation contacts and the isolation contacts and used as a collection contact; and when the stimulation contact delivers electrical stimulation to the patient's internal tissue, the collection contact is used to collect physiological signals from the patient's internal tissue and use them as collection information.

[0180] According to the stimulation parameters and the collected information corresponding to each stimulation contact, a score value of each stimulation contact is determined, and the stimulation contact with the highest score value is used as the recommended stimulation contact.

[0181] Stimulator Embodiments.

[0182] 8A and 8B , which are structural block diagrams of two stimulators with different structures provided in embodiments of the present application.

[0183] The stimulator comprises:

[0184] The implantable electrode 100 according to any one of the above items, wherein the implantable electrode 100 is configured to simultaneously deliver electrical stimulation to the patient's internal tissue and / or collect physiological signals from the patient's internal tissue;

[0185] The pulse generator 200 is electrically connected to the implantable electrode 100, or the pulse generator 200 is electrically connected to the implantable electrode 100 via an extension wire 300. The pulse generator (implantable pulse generator) 200 is configured to analyze the physiological signal and generate the electrical stimulation.

[0186] The implantable electrode 100 is consistent with the embodiments described in the above electrode embodiments and the technical effects achieved are consistent, and some contents are not repeated here.

[0187] Therefore, by cooperating with the pulse generator 200 and the implantable electrode 100, the electrical stimulation parameters can be adjusted according to the patient's physiological signals as feedback information to meet the patient's specific needs and conditions, and to achieve closed-loop control of the patient's electrical stimulation.

[0188] In some embodiments, the pulse generator 200 may include:

[0189] a stimulation contact determination module, configured to use at least one contact in the electrode array module as a stimulation contact according to treatment information of the patient, wherein the stimulation contact is configured to deliver electrical stimulation to an in vivo tissue of the patient;

[0190] an isolation contact point acquisition module configured to acquire, for each stimulation contact point, a plurality of contacts satisfying a preset distance and / or preset position relationship with the stimulation contact point as a center point as isolation contacts;

[0191] The acquisition contact determination module is configured to select contacts other than stimulation contacts and isolation contacts as acquisition contacts based on the treatment information; and when the stimulation contacts deliver electrical stimulation to the patient's internal tissues, use the acquisition contacts to acquire physiological signals from the patient's internal tissues as acquisition information.

[0192] Therefore, by selecting isolation contacts, it is possible to reduce unnecessary effects of stimulation on surrounding tissues, thereby lowering the risks and side effects of treatment. By determining the stimulation contacts, isolation contacts, and collection contacts in the above manner, treatment can be performed. The stimulation contacts are configured to deliver electrical stimulation to tissues, while the collection contacts are configured to monitor the patient's physiological responses, achieving optimal monitoring results.

[0193] In some embodiments, the treatment information includes preset parameters corresponding to each stimulation contact, and the preset parameters are used to indicate the distance relationship or position relationship between the stimulation contact and its corresponding isolation contact.

[0194] In some embodiments, the isolation contact acquisition module may include:

[0195] a parameter prediction unit, configured to input the stimulation parameters corresponding to the stimulation contacts into a prediction model to obtain reference preset parameters corresponding to the stimulation contacts;

[0196] a similarity determination unit configured to obtain a first similarity between the reference preset parameter and the preset parameter;

[0197] a first contact point acquisition unit configured to, when the first similarity is less than a preset similarity, perform an eight-neighborhood search on the stimulation contact using the preset parameters to acquire an isolated contact;

[0198] The second contact acquisition unit is configured to update the preset parameters using the reference preset parameters when the first similarity is not less than the preset similarity, and perform an eight-neighborhood search on the stimulation contact using the updated preset parameters to obtain an isolated contact.

[0199] Therefore, the use of the eight-neighborhood search method can reduce the error in the contact selection process and improve the accuracy and reliability of treatment. If the first similarity is less than the preset similarity, it means that there is a large difference between the preset parameters of the stimulation contact and the reference preset parameters. The preset parameters are determined by the user based on prior calibration and testing, and have relatively high stability and reliability. In this case, the preset parameters of the stimulation contact are used to perform an eight-neighborhood search to obtain the isolated contact. If the first similarity is not less than the preset similarity, it means that the preset parameters of the stimulation contact are relatively close to the reference preset parameters, and then the preset parameters are updated and the updated preset parameters are selected to perform an eight-neighborhood search to obtain the isolated contact.

[0200] In some embodiments, the pulse generator 200 may further include:

[0201] a number counting module configured to, when the first similarity is less than a preset similarity, increase the number of statistics by one and determine whether the number of statistics is greater than a preset number of statistics;

[0202] The risk warning module is configured to generate risk warning information and clear the statistical number when the statistical number is greater than the preset statistical number.

[0203] If the first similarity is less than the preset similarity, it indicates that there is a significant difference between the preset parameters of the stimulation contact and the reference preset parameters. If the first similarity is less than the preset similarity, the number of similarity differences is recorded and a determination is made as to whether the counted number is greater than the preset counted number. If the counted number is greater than the preset counted number, a risk warning message is generated to alert the user or to prompt further action.

[0204] In some embodiments, the pulse generator 200 further includes:

[0205] The recommended contact acquisition module is configured to determine the score value of each stimulation contact based on the stimulation parameters and collection information corresponding to each stimulation contact, and use the stimulation contact with the highest score as the recommended stimulation contact.

[0206] Therefore, by scoring and selecting the stimulation contacts with the highest scores, users can be assisted in making treatment decisions more efficiently.

[0207] Electronic device embodiments.

[0208] As shown in Figure 9, an embodiment of the present application provides an electronic device, comprising a memory 401 and a processor 402. The memory 401 stores a computer program, and the processor 402 is configured to implement any of the methods in the method embodiments when executing the computer program. This embodiment is consistent with the embodiments and technical effects described in the above method embodiments, and some details are not repeated here.

[0209] Storage medium embodiments.

[0210] The embodiment of the present application also provides a computer-readable storage medium, the embodiment of which is consistent with the embodiment described in the above method embodiment and the technical effects achieved, and some contents will not be repeated here.

[0211] The computer-readable storage medium stores a computer program, and when the computer program is executed by at least one processor, the computer program implements the steps of any of the above methods or implements the functions of any of the above stimulators.

[0212] The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. In an embodiment of the present application, a computer-readable storage medium may be any tangible medium containing or storing a program, which may be used by an instruction execution system, device or device or used in combination with the program. A computer-readable storage medium may be, for example, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination thereof. A computer-readable storage medium includes: an electrical connection with one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM), a flash memory, an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination thereof. The storage medium may be a non-transitory storage medium.

[0213] A computer-readable storage medium may include a data signal propagated in baseband or as part of a carrier wave, which carries a readable program code. This propagated data signal may take a variety of forms, including electromagnetic signals, optical signals, or any suitable combination of the above. A computer-readable storage medium may also be any computer-readable medium that can send, propagate, or transmit a program for use by an instruction execution system, apparatus, or device or used in conjunction with it. The program code contained on the computer-readable storage medium may be transmitted using any appropriate medium, including wireless, wired, optical cable, radio frequency (RF), etc., or any suitable combination of the above. The program code for performing the operations of this application may be written in any combination of one or more programming languages, including object-oriented programming languages ​​such as Java, C++, etc., as well as conventional procedural programming languages ​​such as C or similar programming languages. The program code may be executed entirely on the user computing device, partially on the user device, as a separate software package, partially on the user computing device and partially on a remote computing device, or entirely on a remote computing device or server. In situations involving a remote computing device, the remote computing device can be connected to the user computing device through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or it can be connected to an external computing device (for example, through the Internet using an Internet service provider).

[0214] Program Product Embodiments

[0215] The embodiments of the present application also provide a computer program product, the embodiments of which are consistent with the embodiments described in the above method embodiments and the technical effects achieved, and some contents will not be repeated here.

[0216] The computer program product comprises a computer program, which, when executed by at least one processor, implements the steps of any of the above methods or implements the functions of any of the above stimulators.

[0217] See FIG10 , which is a schematic diagram of the structure of a computer program product provided in an embodiment of the present application.

[0218] The computer program product is used to implement the steps of any of the above methods. The computer program product can be a portable CD-ROM and include program code, and can be run on a terminal device, such as a personal computer. However, the computer program product of the present application is not limited to this, and the computer program product can be any combination of one or more computer-readable media.

Claims

1. An implantable electrode, comprising: A control module, the control module being configured to receive a gating instruction of a pulse generator and generate a switch control signal; An array switch, the array switch being configured to establish a multi-path gating channel according to the switch control signal; An electrode array module, the electrode array module comprising a plurality of contacts, each contact being configured to deliver electrical stimulation to the patient's internal tissue through a selection channel established by the array switch and serve as a stimulation contact, or to collect physiological signals from the patient's internal tissue and serve as a collection contact; The switch control signal is used to isolate the stimulation contact for delivering electrical stimulation from the collection contact for collecting physiological signals.

2. The implantable electrode according to claim 1, wherein: The switch control signal includes a high level signal and a low level signal. The high level signal is used to enable the channel of the array switch, and the low level signal is used to disconnect the channel of the array switch.

3. The implantable electrode according to claim 1, wherein: The array switch includes a plurality of switch modules: Wherein, each switch module includes: an insulating layer, the insulating layer being configured to form a receiving cavity; A switch unit, the switch unit being disposed in the accommodating cavity formed by the insulating layer, and the switch unit being configured to establish a gating channel of a contact corresponding to the switch control signal according to the switch control signal; A conductive layer is coated on the outer surface of the insulating layer and is arranged to be grounded through a wire to achieve shielding of at least one of electric field interference or electromagnetic interference.

4. The implantable electrode according to claim 1, wherein: The electrode array module is a Utah electrode.

5. The implantable electrode according to claim 1, wherein: The physiological signal is a local field potential signal.

6. A stimulator, comprising: The implantable electrode according to any one of claims 1 to 5, wherein the implantable electrode is configured to deliver electrical stimulation to the patient's internal tissue and collect physiological signals; A pulse generator is electrically connected to the implanted electrode, or the pulse generator is electrically connected to the implanted electrode through an extension wire, and the pulse generator is configured to analyze the physiological signal and generate the electrical stimulation.

7. A stimulator according to claim 6, wherein The pulse generator comprises: a stimulation contact determination module, configured to use at least one contact in the electrode array module as a stimulation contact according to the treatment information of the patient, wherein the stimulation contact is configured to deliver electrical stimulation to the in vivo tissue of the patient; An isolation contact point acquisition module is configured to acquire, for each stimulation contact point, a plurality of contacts satisfying at least one of a preset distance or a preset position relationship with the stimulation contact point as a center point as isolation contacts; The acquisition contact determination module is configured to select contacts from the stimulation contacts and contacts other than the isolation contacts as acquisition contacts based on the treatment information; and when the stimulation contacts deliver electrical stimulation to the patient's internal tissues, use the acquisition contacts to acquire physiological signals from the patient's internal tissues and use the acquired physiological signals as acquisition information.

8. A stimulator according to claim 7, wherein The treatment information includes preset parameters corresponding to each stimulation contact, and the preset parameters are used to indicate the distance relationship or position relationship between the stimulation contact and the isolation contact corresponding to the stimulation contact.

9. A stimulator according to claim 8, wherein The isolation contact acquisition module comprises: A parameter prediction unit, configured to input the stimulation parameters corresponding to the stimulation contacts into a prediction model to obtain reference preset parameters corresponding to the stimulation contacts; A similarity determination unit, configured to obtain a first similarity between the reference preset parameter and the preset parameter; a first contact point acquisition unit, configured to, in response to the first similarity being less than a preset similarity, perform an eight-neighborhood search on the stimulation contact using the preset parameters to acquire the isolated contact; The second contact acquisition unit is configured to update the preset parameters using the reference preset parameters in response to the first similarity being not less than the preset similarity, and perform an eight-neighborhood search on the stimulation contact using the updated preset parameters to acquire the isolated contact.

10. The stimulator according to claim 9, wherein The pulse generator also includes: a number counting module, configured to, in response to the first similarity being less than the preset similarity, increase the number of statistics by one and determine whether the number of statistics is greater than the preset number of statistics; The risk warning module is configured to generate risk warning information and clear the statistical number in response to the statistical number being greater than the preset statistical number.

11. The stimulator according to claim 7, wherein: The pulse generator also includes: The recommended contact acquisition module is configured to determine the score value of each stimulation contact according to the stimulation parameters and collection information corresponding to each stimulation contact, and use the stimulation contact with the highest score value as the recommended stimulation contact.

12. A method for controlling a stimulator, comprising: Using at least one contact in the electrode array module as a stimulation contact according to the patient's treatment information, the stimulation contact being used to deliver electrical stimulation to the patient's body tissue; For each stimulation contact point, taking the stimulation contact point as a center point, a plurality of contacts satisfying at least one of a preset distance or a preset position relationship are obtained as isolation contacts; According to the treatment information, a contact is selected from the stimulation contact and the contacts other than the isolation contact and used as a collection contact; and when the stimulation contact delivers electrical stimulation to the patient's internal tissue, the collection contact is used to collect physiological signals from the patient's internal tissue and the collected physiological signals are used as collection information.

13. The control method according to claim 12, wherein: The treatment information includes preset parameters corresponding to each stimulation contact, and the preset parameters are used to indicate the distance relationship or position relationship between the stimulation contact and the isolation contact corresponding to the stimulation contact.

14. The control method according to claim 13, wherein: For each stimulation contact point, taking the stimulation contact point as a center point, obtaining a plurality of contacts satisfying at least one of a preset distance or a preset position relationship as isolation contacts, including: Inputting the stimulation parameters corresponding to the stimulation contacts into the prediction model to obtain the reference preset parameters corresponding to the stimulation contacts; Obtaining a first similarity between the reference preset parameter and the preset parameter; In response to the first similarity being less than a preset similarity, performing an eight-neighborhood search on the stimulation contact using the preset parameters to obtain the isolated contact; In response to the first similarity being not less than the preset similarity, the preset parameters are updated using the reference preset parameters, and an eight-neighborhood search is performed on the stimulation contact using the updated preset parameters to obtain the isolated contact.

15. An electronic device comprising a memory and a processor, wherein the memory stores a computer program, and the processor implements the control method of the stimulator according to any one of claims 12 to 14 when executing the computer program.

16. A computer-readable storage medium, wherein: The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the control method of the stimulator according to any one of claims 12 to 14 is implemented.

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