Steam sterilization of hydrogels crosslinked by beta-eliminative linkers

AU2020327038B2Pending Publication Date: 2026-07-16PROLYNX LLC
View PDF 1 Cites 0 Cited by

Patent Information

Application Number
AU2020327038
Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
Priority Date
2019-08-07
Filing Date
2020-08-07
Publication Date
2026-07-16
Estimated Expiration
2040-08-07

AI Technical Summary

Technical Problem

Sterilization of degradable polymeric biomaterials, particularly hydrogels crosslinked by beta-eliminative linkers, poses challenges due to significant chemical degradation and reproducibility issues with existing methods, making it difficult to achieve adequate sterility for clinical use.

Method used

The method involves sterilizing hydrogels crosslinked with beta-eliminative linkers by exposing them to a non-reactive buffer at controlled pH values between 2 and 4, typically at 121 °C for up to 1 hour, minimizing crosslink cleavage during the process.

Benefits of technology

This approach effectively sterilizes hydrogels while maintaining the integrity of crosslinks and functional groups, ensuring consistent quality and regulatory compliance by preserving the hydrogel's properties and sterility.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 00000001_0000
    Figure 00000001_0000
  • Figure 00000039_0000
    Figure 00000039_0000
  • Figure 00000040_0000
    Figure 00000040_0000
Patent Text Reader

Abstract

Methods for the steam sterilization of hydrogels crosslinked with a beta-eliminative linker without the drawback of significant degradation are provided.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Hydrogels with biodegradable crosslinking

    US20140288190A1