Steam sterilization of hydrogels crosslinked by beta-eliminative linkers

AU2020327038B2Pending Publication Date: 2026-07-16PROLYNX LLC
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
PROLYNX LLC
Filing Date
2020-08-07
Publication Date
2026-07-16

AI Technical Summary

Technical Problem

Sterilization of degradable polymeric biomaterials, particularly hydrogels crosslinked by beta-eliminative linkers, poses challenges due to significant chemical degradation and reproducibility issues with existing methods, making it difficult to achieve adequate sterility for clinical use.

Method used

The method involves sterilizing hydrogels crosslinked with beta-eliminative linkers by exposing them to a non-reactive buffer at controlled pH values between 2 and 4, typically at 121 °C for up to 1 hour, minimizing crosslink cleavage during the process.

Benefits of technology

This approach effectively sterilizes hydrogels while maintaining the integrity of crosslinks and functional groups, ensuring consistent quality and regulatory compliance by preserving the hydrogel's properties and sterility.

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Abstract

Methods for the steam sterilization of hydrogels crosslinked with a beta-eliminative linker without the drawback of significant degradation are provided.
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