Peptide tags and binding partners

By designing peptide tags and binding partners that form spontaneous isopeptide bonds, the stability and binding efficacy of protein interactions are improved, addressing the instability of existing systems and enhancing detection and purification processes.

AU2021268757B2Pending Publication Date: 2026-07-09ADAPTVAC APS
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
ADAPTVAC APS
Filing Date
2021-05-07
Publication Date
2026-07-09

AI Technical Summary

Technical Problem

Existing peptide tag and binding partner systems for protein manipulation and analysis lack stable, irreversible interactions under biological conditions, particularly in the formation of isopeptide bonds, which are prone to dissociation and not resistant to proteases.

Method used

Designing peptide tags and binding partners capable of forming spontaneous isopeptide bonds by identifying reactive residues and producing modified fragments that covalently bind, ensuring stability and irreversibility through isopeptide bond formation.

Benefits of technology

Enhances the stability and binding efficacy of peptide-protein interactions, allowing for improved detection, purification, and display of molecules on virus-like particles, with increased binding rates and total binding capabilities.

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Abstract

The present invention relates to peptide tags and binding partners which are capable of interacting via the spontaneous formation of an isopeptide bond, as well as to associated peptide pairs and methods for designing peptide tags, binding partners and peptide pairs with improved properties.
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