In-vivo electrochemical affinity biosensing with artifact attenuation

The device uses a detection circuit with a high sampling frequency and artifact filtering to enhance the accuracy of in-vivo electrochemical sensors by isolating the target signal from mechanical, physiological, and electrical noise, addressing the challenges of artifact interference in aptamer-based sensors.

AU2024403210A1Pending Publication Date: 2026-07-09UNIVERSITY OF CINCINNATI
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
UNIVERSITY OF CINCINNATI
Filing Date
2024-12-23
Publication Date
2026-07-09

AI Technical Summary

Technical Problem

Aptamer-based electrochemical sensors face challenges in in-vivo testing due to mechanical, physiological, and electrical artifacts that reduce precision and accuracy by distorting redox peak heights and overshadowing true redox signals, making it difficult to detect subtle changes in analyte concentration.

Method used

A device with a detection circuit that applies a sampling frequency higher than the largest known artifact frequency, uses a Fourier Transform to identify artifacts, and applies filters to attenuate them, allowing for accurate measurement of analyte concentration by filtering out artifacts.

Benefits of technology

The solution effectively attenuates artifacts, enhancing the precision and accuracy of in-vivo electrochemical measurements by isolating the target signal from noise, thereby improving the detection of subtle analyte concentration changes.

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Abstract

A device for measuring an analyte comprises a sensor including an electrode with an aptamer and an attached redox couple. The sensor is adapted to electrochemically measure a change in concentration of the analyte. The device further comprises a detection circuit configured to select a sampling frequency at which a measurement is taken. The detection circuit is further configured to periodically apply an input voltage to an electrode to obtain a measured response of the electrode. The measured response includes a target signal of the aptamer and an artifact. The detection circuit is further configured to detect the artifact using a transformative tool. The detection circuit is further configured to apply a filter to the measured response of the electrode to attenuate or remove the artifact. The detection circuit is further configured to measure the analyte using the target signal and not the artifact.
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