Systems and methods for adjusting stimulation based on seizure frequency

The medical device adjusts electrical stimulation based on intraday and multi-day seizure patterns to optimize nerve stimulation for epilepsy, effectively reducing seizures by aligning with norepinephrine variability.

AU2025214627A1Pending Publication Date: 2026-07-16ALFRED E MANN FOUND FOR SCI RES
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
ALFRED E MANN FOUND FOR SCI RES
Filing Date
2025-01-29
Publication Date
2026-07-16

AI Technical Summary

Technical Problem

Existing nerve stimulation methods for epilepsy, such as VNS, DBS, and RNS, struggle to adjust electrical stimulation effectively due to the variability in norepinephrine levels throughout the day and over multiple days, which affects seizure frequency and severity.

Method used

A medical device with an implantable pulse generator (IPG) that adjusts the duty cycle of electrical stimulation based on time-variable primary duty cycle transfer functions, incorporating intraday and multi-day patterns of seizure rates to optimize stimulation according to norepinephrine levels.

Benefits of technology

This approach reduces the likelihood and severity of seizures by aligning stimulation with seizure patterns, balancing the need to prevent seizures without depleting norepinephrine or the device's power source.

✦ Generated by Eureka AI based on patent content.

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Abstract

A medical device includes an implantable pulse generator (IPG), and the IPG includes a driver configured to generate a stimulation current having a duty cycle; a memory storing instructions; and a microcontroller circuit operatively coupled to the driver and to the memory, and configured, in response to executing the instructions stored in the memory, to cause the driver to vary the duty cycle based at least in part by a time- variable primary duty cycle transfer function.
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