Drug delivery device

Abstract

The present invention discloses a novel drug delivery introduction device, including an injection syringe, a guide head, a microneedle and an adjustment cover, wherein the adjustment cover rotates relative to the microneedle; the injection syringe includes a syringe and a piston push rod inserted in the syringe; the microneedle includes a substrate, a microneedle module arranged in the middle of the substrate, and a plurality of water drop-shaped drug delivery holes provided on the substrate, wherein the drug delivery holes are distributed at equal intervals in the periphery of the microneedle module along the circumferential direction; a through hole for the microneedle module to pass through is provided in the middle of the adjustment cover, and a plurality of adjustment holes for cooperating with the drug delivery holes to adjust the drug delivery flow rate are provided on the adjustment cover at the periphery of the through hole, and the number of the adjustment holes is consistent with the number of the drug delivery holes. The present invention can not only freely absorb the required drug for injection, thus improving its flexibility of use, but also prevent the needle from breaking, thus avoiding damage to the skin caused by the needle breaking in the skin, and can also linearly adjust the drug delivery flow rate, thus meeting the use requirements of different users.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a drug delivery device. Background Art

[0002] With the development of society and the improvement of science and technology, medical and health issues are receiving more and more attention from people. Among the current treatment methods, drug therapy is the most common treatment method. Its treatment principle is to transfer drugs from outside the body to the human body through a certain transport method to produce drug effects.

[0003] Transdermal Drug Delivery (TDD) refers to the absorption of drugs through the skin into the blood circulation at a certain rate to achieve effective blood drug concentrations to achieve the treatment or prevention of diseases. With the development of biotechnology, there are more and more biological preparations based on macromolecules such as peptides, proteins, and oligonucleotides. The route of administration is a common problem encountered by biological preparations in clinical applications. Because biological preparations are easily degraded in the liver and gastrointestinal tract when taken orally, reducing the effective utilization of biological preparations; it is difficult to maintain a stable blood drug concentration in the body when injected, and frequent injections will also cause great inconvenience and pain to patients. Therefore, transdermal administration has attracted much attention as the third largest mode of administration besides oral and injection. Compared with ordinary administration methods, transdermal administration has the following advantages:

[0004] (1) Avoid the liver "first-pass effect" and gastrointestinal inactivation that may occur when the drug is taken orally, and improve the therapeutic effect;

[0005] (2) Control the dosage and release time of the drug to ensure a constant blood drug concentration in the body;

[0006] (3) Improve the safety of medication. If adverse reactions are found, medication can be stopped immediately to reduce the risks of oral or intramuscular injection.

[0007] (4) Provide a gentle way of drug administration, improve the adaptability of the recipient, avoid children's fear of seeing needles and avoid inaccurate drug administration due to the recipient's unfamiliarity with the medication regimen.

[0008] However, the drugs in the prior art transdermal drug delivery devices are all pre-loaded, which makes them inflexible to use. In addition, the needles of the prior art transdermal drug delivery devices are relatively fragile and easily break in the skin. Moreover, since the needles are tiny, even if they break in the skin, they are not easily detected and easily remain in the skin to cause damage to the skin. In addition, the prior art drug delivery devices cannot control the drug delivery flow rate according to the use requirements during injection. Therefore, the prior art drug delivery devices can no longer meet the current use requirements, and how to improve the prior art drug delivery devices is the focus of research by those skilled in the art. Summary of the invention

[0009] The purpose of the present invention is to provide a drug delivery device, which can not only freely absorb the required drug for injection, thereby improving its flexibility of use, but also prevent the needle from breaking, avoid damage to the skin caused by the needle breaking in the skin, and can linearly adjust the drug delivery flow rate to meet the usage needs of different users.

[0010] To achieve the above-mentioned invention object, the technical solution adopted by the present invention is: a drug delivery device, comprising an injection syringe, a guide head sleeved at the liquid outlet of the injection syringe, a microneedle embedded on the guide head, and an adjustment cover covering the microneedle, wherein the adjustment cover rotates relative to the microneedle;

[0011] The injection syringe component comprises a syringe and a piston push rod inserted in the syringe;

[0012] The microneedle component includes a substrate, a microneedle module arranged in the middle of the substrate, and a plurality of water drop-shaped drug delivery holes opened on the substrate, wherein the drug delivery holes are distributed at equal intervals around the periphery of the microneedle module along the circumferential direction;

[0013] A through hole is provided in the middle of the regulating cover for the microneedle module to pass through, and a plurality of regulating holes are provided on the regulating cover at the periphery of the through hole for cooperating with the drug delivery hole to adjust the drug delivery flow rate, and the number of the regulating holes is consistent with the number of the drug delivery holes.

[0014] In the above technical solution, the outer surface of the syringe is provided with scales along its length direction.

[0015] In the above technical solution, two baffles are symmetrically arranged on the outer surface of the bottom of the syringe, and the baffles are perpendicular to the outer surface of the syringe.

[0016] In the above technical solution, a truncated cone-shaped connector is provided on the top of the syringe, the liquid outlet is arranged on the connector and communicated with the inside of the syringe, and the guide sleeve is arranged on the connector.

[0017] In the above technical solution, a cavity for accommodating the microneedle component is formed at the upper end of the guide head, an annular groove is formed inside the opening of the cavity, and the substrate of the microneedle component is overlapped on the annular groove and sealedly connected to the annular groove.

[0018] In the above technical solution, a limiting ring is provided on the inner surface of the bottom of the adjusting cover, and an annular limiting groove corresponding to the limiting ring is provided on the outer surface of the guide head.

[0019] In the above technical solution, a breaking portion is provided on the piston push rod near the piston.

[0020] In the above technical solution, the base plate is provided with four dosing holes, and the regulating cover is provided with four regulating holes.

[0021] In the above technical solution, the aperture of the regulating hole is consistent with the aperture of the end of the drug delivery hole.

[0022] In the above technical solution, the microneedles of the microneedle module are superconducting microneedles, and the height of the superconducting microneedles is 0-500 μm.

[0023] Due to the application of the above technical solution, the present invention has the following advantages compared with the prior art:

[0024] 1. The present invention realizes free absorption and quantitative injection of drugs through the injection syringe, improves its flexibility of use, and realizes linear adjustment of drug flow through the adjustment cover and the microneedle component to meet the drug administration needs of different users;

[0025] 2. The microneedles of the present invention are superconducting microneedles, which can effectively prevent the needle tip from breaking and avoid damage to the skin caused by the needle tip breaking in the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural diagram of embodiment 1 of the present invention.

[0027] Figure 2 It is a schematic structural diagram of the adjusting cover of the first embodiment of the present invention.

[0028] Figure 3 It is a schematic diagram of the structure of the microneedle component of the first embodiment of the present invention.

[0029] Among them: 1. guide head; 2. microneedle component; 3. adjustment cover; 4. syringe; 5. piston push rod; 6. substrate; 7. microneedle module; 8. drug delivery hole; 9. through hole; 10. adjustment hole; 11. baffle; 12. connector; 13. cavity; 14. annular groove; 15. limiting ring; 16. annular limiting groove; 17. breaking part; 18. end of drug delivery hole. DETAILED DESCRIPTION

[0030] The present invention will be further described below in conjunction with the accompanying drawings and embodiments:

[0031] Embodiment 1:

[0032] See also Figures 1 to 3 As shown, a drug delivery device comprises an injection syringe, a guide head 1 sleeved at a liquid outlet of the injection syringe, a microneedle 2 embedded on the guide head, and an adjustment cover 3 covering the microneedle, wherein the adjustment cover rotates relative to the microneedle, wherein the adjustment cover is sleeved on the guide head and covers the microneedle, and the lower surface of the adjustment cover is close to the upper surface of the microneedle;

[0033] The injection syringe component comprises a syringe 4 and a piston push rod 5 inserted in the syringe;

[0034] The microneedle component includes a substrate 6, a microneedle module 7 disposed in the middle of the substrate, and four teardrop-shaped drug delivery holes 8 opened on the substrate, wherein the drug delivery holes are distributed at equal intervals around the periphery of the microneedle module along the circumferential direction;

[0035] A through hole 9 for the microneedle module to pass through is provided in the middle of the regulating cover, and four regulating holes 10 for cooperating with the drug delivery hole to adjust the drug delivery flow rate are provided on the regulating cover at the periphery of the through hole.

[0036] In this embodiment, the outer surface of the syringe is provided with scales along its length direction to achieve quantitative dosing.

[0037] In this embodiment, two baffles 11 are symmetrically arranged on the outer surface of the bottom of the syringe, and the baffles are perpendicular to the outer surface of the syringe. The baffles can be arranged to facilitate the clamping and fixing of the instrument.

[0038] In this embodiment, a truncated cone-shaped connector 12 is provided on the top of the syringe, the liquid outlet is arranged on the connector and is connected to the inside of the syringe, and the guide head is sleeved on the connector. The connection and fixing method between the guide head and the connector can refer to the connection method between the syringe and the needle of an existing ordinary syringe, and the guide head only needs to be inserted into the connector.

[0039] In this embodiment, a cavity 13 for accommodating a microneedle component is formed at the upper end of the guide head, an annular groove 14 is formed inside the opening of the cavity, and a substrate of the microneedle component is overlapped on the annular groove and sealedly connected to the annular groove.

[0040] In this embodiment, a limiting ring 15 is provided on the inner surface of the bottom of the adjusting cover, and an annular limiting groove 16 corresponding to the limiting ring is provided on the outer surface of the guide head. In fact, the adjusting cover is a structure with a slight elasticity, so as to ensure that the limiting ring can be stuck in the annular limiting groove when the adjusting cover is installed on the guide head.

[0041] In this embodiment, a breaking portion 17 is provided on the piston push rod near the piston, which is used to break the piston push rod after use to avoid repeated use.

[0042] In this embodiment, the aperture of the adjustment hole is consistent with the aperture of the end 18 of the dosing hole. It should be noted that the teardrop-shaped dosing hole refers to an aperture that decreases from a smooth arc portion at one end to a tip portion at the other end. The smooth arc portion here corresponds to the end portion of the dosing hole, and the tip portion is defined as the tail portion of the dosing hole. The present invention achieves flow regulation by changing the relative position of the adjustment hole and the dosing hole. Specifically, when the adjustment hole coincides with the end portion of the dosing hole, the flow rate is maximum; when the adjustment hole moves relatively from the end portion to the tail portion of the dosing hole, the flow rate gradually decreases; when the adjustment hole does not coincide with the dosing hole, medication cannot be administered.

[0043] In this embodiment, the microneedles of the microneedle module are superconducting microneedles, the height of the superconducting microneedles is 0-500 μm, the superconducting microneedles are stable in structure, not easy to break, and can avoid damage to the skin caused by the needle tip breaking in the skin. Specifically, the present invention uses micron-level microneedles, and by controlling the needle height, only opens the stratum corneum of the skin to form a liquid supply channel, does not reach the dermis of the skin, and is absorbed through diffusion of the epidermis, thereby achieving the purpose of painlessness, safety, and high efficiency.

[0044] The assembled drug delivery device is installed on a customized instrument. Through the high-speed vibration of the instrument, the drug solution flows out by itself under the action of the aerodynamic force of the liquid tube, thus realizing the function of drug and device integration. The drug solution enters the body while the microneedle opens the skin channel, and is absorbed by the human skin after diffusion.

[0045] Supplementary explanation: The upper, lower, top and bottom mentioned in the present invention are based on the direction of placing the device of the present invention vertically with one end of the microneedle member facing upward.

[0046] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to the above embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the above embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A drug delivery device, characterized in that: It comprises an injection syringe, a guide head sleeved at a liquid outlet of the injection syringe, a microneedle embedded on the guide head, and an adjustment cover covering the microneedle, wherein the adjustment cover rotates relative to the microneedle; The injection syringe component comprises a syringe and a piston push rod inserted in the syringe; two baffles are symmetrically arranged on the outer surface of the bottom of the syringe, and the baffles are perpendicular to the outer surface of the syringe; The microneedle component comprises a substrate, a microneedle module arranged in the middle of the substrate, and a plurality of water drop-shaped drug delivery holes opened on the substrate, wherein the drug delivery holes are distributed at equal intervals along the circumferential direction at the periphery of the microneedle module; the microneedles of the microneedle module are superconducting microneedles, and the height of the superconducting microneedles is 0-500 μm; A through hole is provided in the middle of the regulating cover for the microneedle module to pass through, and a plurality of regulating holes are provided on the regulating cover at the periphery of the through hole for cooperating with the drug delivery hole to adjust the drug delivery flow rate, and the number of the regulating holes is consistent with the number of the drug delivery holes; The upper end of the guide head is provided with a cavity for accommodating the microneedle component, the inner side of the opening of the cavity is provided with an annular groove, and the substrate of the microneedle component is overlapped on the annular groove and is sealedly connected to the annular groove; A limiting ring is arranged on the inner surface of the bottom of the regulating cover, and an annular limiting groove corresponding to the limiting ring is arranged on the outer surface of the guide head.

2. The drug delivery device according to claim 1, characterized in that: The outer surface of the syringe is provided with scales along the length direction thereof.

3. The drug delivery device according to claim 1, characterized in that: A truncated cone-shaped connector is provided on the top of the syringe, the liquid outlet is arranged on the connector and communicated with the inside of the syringe, and the guide head sleeve is arranged on the connector.

4. The drug delivery device according to claim 1, characterized in that: A breaking portion is provided on the piston push rod near the piston.

5. The drug delivery device according to claim 1, characterized in that: The base plate is provided with four dosing holes, and the regulating cover is provided with four regulating holes.

6. The drug delivery device according to claim 1 or 5, characterized in that: The aperture of the regulating hole is consistent with the aperture of the end of the drug delivery hole.

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