Optical detection device

Abstract

The present invention discloses an optical detection device, comprising: a detection chamber, a conveyor mechanism for conveying a test tube rack arranged in the detection chamber, a photomultiplier tube for optically detecting a sample in a test tube on the test tube rack, a lens shutter mechanism arranged in the detection chamber, and a chamber door mechanism arranged on the detection chamber. The present invention can realize automatic detection of multiple test tubes on the test tube rack in the detection chamber at one time by arranging the conveyor mechanism, and the detection flux and efficiency are greatly improved; the chamber door mechanism of the present invention, when the conveyor body moves out of the detection chamber, the chamber door is automatically opened, and when the conveyor returns to the detection chamber, the chamber door will return to its original position under the action of a shrapnel and a magnet, which is convenient and fast; by arranging the lens shutter mechanism, when no detection is performed, the lens of the photomultiplier tube is blocked by the shutter, and when detection is performed, the shutter is automatically moved away. The present invention can realize fully automatic optical detection, and has high detection flux and efficiency.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro diagnosis, and in particular to an optical detection device. Background Art

[0002] Optical detection devices are widely used in in vitro diagnostics and are key components of fully automated optical detection instruments. However, current optical detection devices typically have only one station, low detection throughput, and a low degree of automation. Samples typically enter and exit the optical detection device through a door, which either fails to open automatically or requires an additional drive mechanism. This reduces efficiency, increases equipment costs, and makes it difficult to meet the current market demand for fully automated sample testing. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide an optical detection device in view of the deficiencies in the above-mentioned prior art.

[0004] To solve the above technical problems, the present invention adopts a technical solution: an optical detection device, comprising: a detection chamber, a conveyor mechanism disposed within the detection chamber for conveying a test tube rack, a photomultiplier tube for optically detecting samples in test tubes on the test tube rack, a lens shutter mechanism disposed within the detection chamber, and a chamber door mechanism disposed on the detection chamber.

[0005] Preferably, the transport vehicle mechanism includes a transport vehicle body, a driving mechanism for driving the transport vehicle body to reciprocate along the Y direction, and a position detection mechanism for detecting the position of the transport vehicle body.

[0006] Preferably, the driving mechanism includes a first motor arranged on the inspection bin, a driving pulley connected to the output shaft of the first motor, a driven pulley arranged on the opposite side of the driving pulley along the Y direction, a belt arranged between the driving pulley and the driven pulley, a slide rail arranged on the bottom plate of the inspection bin along the Y direction, and a slider slidably arranged on the slide rail and connected to the belt at one end and the conveyor vehicle body at the other end.

[0007] Preferably, the position detection mechanism includes a bar code ruler fixedly connected to the slider, a plurality of position detection slots provided on the bar code ruler along the Y direction, and a photoelectric switch for cooperating with the position detection slots.

[0008] Preferably, a receiving slot for accommodating the test tube rack is provided on the transport vehicle body, the test tube rack is inserted into the receiving slot from the front end of the transport vehicle body, a spring slot is provided at the rear end of the test tube rack, and a clamping spring is provided at the rear end of the receiving slot for cooperating with the spring slot.

[0009] Preferably, a plurality of through holes corresponding to the positions and numbers of the test tubes on the test tube racks are formed on the bottom of the transport vehicle body.

[0010] Preferably, the clamping spring is U-shaped, the middle portion of the U-shape is fixedly connected to the rear end of the accommodating groove, and both ends of the U-shape protrude inward to form a clamping protrusion.

[0011] Preferably, a detection hole is opened on the bottom plate of the detection chamber, the photomultiplier tube is arranged below the detection hole, and the lens shutter mechanism includes a shutter arranged at the detection hole and a driving module for driving the shutter to move.

[0012] Preferably, the door mechanism includes a door, a connecting rod seat, a connecting rod, and a reset spring; an opening for the transport vehicle body to enter and exit is provided on the side of the inspection chamber, and the door is provided at the opening; the connecting rod seat is fixedly connected to the bottom surface of the bottom plate of the inspection chamber; one end of the connecting rod is rotatably connected to the connecting rod seat, and the other end thereof has an L-shaped connecting portion, and the door is connected to the L-shaped connecting portion;

[0013] One end of the reset spring covers the connecting rod seat and is fixedly connected to the outer wall of the bottom of the detection chamber, and the other end covers the connecting rod.

[0014] Preferably, a plurality of magnet blocks are also provided on the warehouse door.

[0015] The beneficial effects of the present invention are as follows: the optical detection device of the present invention can realize automatic detection of multiple test tubes on a test tube rack in the detection chamber at one time by setting a conveyor mechanism, thereby greatly improving the detection flux and efficiency; by setting a position detection mechanism, each test tube can be aligned with the photomultiplier tube at the detection position; the chamber door mechanism of the present invention is such that when the conveyor body moves out of the detection chamber, the chamber door is automatically opened, and when the conveyor returns to the detection chamber, the chamber door will return to its original position under the action of the shrapnel and the magnet, which is convenient and fast; by setting a lens shutter mechanism, when not detecting, the lens of the photomultiplier tube is blocked by the shutter, and when detecting, the shutter is automatically moved away. The present invention can realize fully automatic optical detection, such as fluorescent immunoassay, chemiluminescence detection, etc., with high detection flux and efficiency, simple structure, and can also be used as an independent module in fully automatic detection and analysis equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Schematic diagram of the internal structure of the optical detection device of the present invention;

[0017] Figure 2 is a schematic structural diagram of the bottom portion of the optical detection device of the present invention;

[0018] Figure 3It is a structural schematic diagram of the door mechanism of the present invention;

[0019] Figure 4 It is a structural schematic diagram of the transport vehicle body of the present invention;

[0020] Figure 5 This is a schematic structural diagram of a test tube rack corresponding to the transport vehicle body in one embodiment of the present invention;

[0021] Figure 6 Schematic diagram of the structure of the barcode ruler of the present invention.

[0022] Description of reference numerals:

[0023] 1—Detection chamber; 2—Conveyor vehicle mechanism; 3—Photomultiplier tube; 4—Lens shutter mechanism; 5—Case door mechanism; 6—Test tube rack; 7—Test tube; 10—Detection hole; 11—Opening; 20—Conveyor vehicle body; 21—Drive mechanism; 22—Position detection mechanism; 23—Adapter plate; 24—Through hole; 40—Shutter; 41—Drive module; 50—Case door; 51—Connecting rod seat; 52—Connecting rod; 53—Reset spring; 60—Spring slot; 200—Accommodating slot; 201—Clamping spring; 202—Clamping protrusion; 210—First motor; 211—Drive pulley; 212—Driven pulley; 213—Belt; 214—Slide rail; 215—Slider; 220—Barcode ruler; 221—Position detection slot; 222—Photoelectric switch; 500—Magnet block; 520—L-shaped connecting part. DETAILED DESCRIPTION

[0024] The present invention is further described in detail below with reference to the embodiments so that those skilled in the art can implement the invention with reference to the description.

[0025] It should be understood that terms such as “having”, “including” and “comprising” used herein do not preclude the existence or addition of one or more other elements or combinations thereof.

[0026] like Figure 1-6 As shown, an optical detection device of this embodiment includes: a detection chamber 1, a conveyor mechanism 2 arranged in the detection chamber 1 for conveying a test tube rack 6, a photomultiplier tube 3 for optically detecting samples in a test tube on the test tube rack 6, a lens shutter mechanism 4 arranged in the detection chamber 1, and a chamber door mechanism 5 arranged on the detection chamber 1.

[0027] The transport vehicle mechanism 2 includes a transport vehicle body 20 , a driving mechanism 21 for driving the transport vehicle body 20 to reciprocate along the Y direction, and a position detection mechanism 22 for detecting the position of the transport vehicle body 20 .

[0028] In one embodiment, the drive mechanism 21 includes a first motor 210 disposed on the inspection chamber 1, a driving pulley 211 connected to the output shaft of the first motor 210, a driven pulley 212 disposed on the opposite side of the driving pulley 211 along the Y direction, a belt 213 disposed between the driving pulley 211 and the driven pulley 212, a slide rail 214 disposed on the bottom plate of the inspection chamber 1 along the Y direction, and a slider 215 slidably disposed on the slide rail 214 and connected to the belt 213 at one end and connected to the transport vehicle body 20 at the other end. The first motor 210 is preferably a stepping motor, and the first motor 210 rotates through the belt 213 to drive the slider 215 to move, and by controlling the forward and reverse rotation of the motor, the transport vehicle body 20 is driven to reciprocate along the Y direction. In this embodiment, the transport vehicle body 20 is connected to the slider 215 via an adapter plate 23.

[0029] The transport vehicle body 20 is provided with a receiving slot 200 for receiving the test tube rack 6. The test tube rack 6 is inserted into the receiving slot 200 from the front end of the transport vehicle body 20. The test tube rack 6 is loaded with a number of test tubes 7. The samples in the test tubes 7 are optically detected by a photomultiplier tube. Figure 5 FIG. 6 is a structural diagram of a test tube rack 6 that cooperates with the transport vehicle body 20 of the present invention. The rear end of the test tube rack 6 is provided with a spring slot 60. Figure 4 The rear end of the receiving groove 200 is provided with a locking spring 201 that engages with the spring slot 60. The locking spring 201 is U-shaped, with the middle portion of the U fixedly connected to the rear end of the receiving groove 200, and the ends of the U protruding inward to form locking protrusions 202. After the test tube rack 6 is pushed into the receiving groove 200, the locking spring 201 engages with the spring slot 60 at the rear end of the test tube rack 6, achieving a locking effect and ensuring a tight connection between the test tube rack 6 and the transport vehicle body 20.

[0030] The bottom of the transport vehicle body 20 is provided with a plurality of through-holes 24 corresponding to the position and number of test tubes 7 on the test tube rack 6. After the test tube rack 6 is pushed into the receiving slot 200, the through-holes 24 on the bottom of the transport vehicle body 20 correspond one-to-one with the test tubes 7 and are located directly below the test tubes 7. When the transport vehicle body 20 reaches the detection position, the test tubes 7 in the detection holes 10 can be optically detected by the photomultiplier tubes 3 below.

[0031] In one embodiment, the position detection mechanism 22 includes a barcode ruler 220 fixed to the slider 215, a plurality of position detection slots 221 defined along the Y direction on the barcode ruler 220, and a photoelectric switch 222 configured to cooperate with the position detection slots 221. The barcode ruler 220 is fixed to the slider 215 via an adapter plate 23. The photoelectric switch 222 detects the position of the position detection slots 221 on the barcode ruler 220 to position the test tube rack 6 on the transport vehicle body 20, ensuring that the test tubes on the test tube rack 6 are sequentially optically inspected in the inspection holes 10.

[0032] For example, in this embodiment, 12 test tubes are provided on the test tube rack 6, and at least 13 position detection slots 221 are provided on the bar code ruler 220. Each test tube has a corresponding position detection slot 221 to detect its position. Driven by the first motor 210, the test tube rack 6 moves from front to back on the slide rail 214. When the test tube at the rear end of the test tube rack 6 reaches above the detection hole 10, the corresponding position detection slot 221 on the bar code ruler 220 reaches the photoelectric switch 222, achieving positioning. The test tube rack 6 gradually moves, and the test tubes successively reach above the detection hole 10 for optical detection. The photoelectric switch 222 cooperates with each position detection slot 221 to achieve one-to-one positioning of the 12 test tubes. In a further embodiment, the photoelectric switch 222 can also detect the docking position of the transport vehicle body 20. The test tube rack 6 is transported to the transport vehicle body 20 by an external conveying mechanism. After the detection is completed, the test tube rack 6 is then transported to the next workstation by the conveying mechanism. When the front end of the transport vehicle body 20 extends 30 mm, it serves as the docking position. At this time, the position detection groove 221 on the barcode ruler 220 corresponding to the docking position is at the position detection groove 221, thereby achieving positioning.

[0033] In one embodiment, a detection hole 10 is defined on the bottom plate of the detection chamber 1, and a photomultiplier tube 3 is disposed below the detection hole 10. The lens-shutter mechanism 4 includes a shutter 40 disposed at the detection hole 10 and a drive module 41 for driving the shutter 40. In a preferred embodiment, the drive module 41 is an electromagnet. When performing detection, the electromagnet is energized, driving the shutter 40 to open. When not performing detection, the electromagnet is de-energized, closing the shutter 40 and blocking the lens of the photomultiplier tube 3. Of course, the drive module 41 may also be another power mechanism capable of driving the shutter 40 to repeatedly move over the detection hole 10.

[0034] In one embodiment, the door mechanism 5 includes a door 50, a connecting rod seat 51, a connecting rod 52, and a reset spring 53. An opening 11 is provided on the side of the inspection chamber 1 for the transport vehicle body 20 to enter and exit, and the door 50 is disposed at the opening 11. The connecting rod seat 51 is fixedly connected to the bottom surface of the bottom plate of the inspection chamber 1. One end of the connecting rod 52 is rotatably connected to the connecting rod seat 51, and the other end has an L-shaped connecting portion 520. The door 50 is connected to the L-shaped connecting portion 520. One end of the reset spring 53 covers the connecting rod seat 51 and is fixedly connected to the outer wall of the bottom of the inspection chamber 1. The other end of the reset spring 53 covers the connecting rod 52. Several magnet blocks 500 are also provided on the door 50.

[0035] When the transport vehicle body 20 moves out of the inspection chamber 1, the chamber door 50 is pushed open by the transport vehicle body 20. When the transport vehicle returns to the inspection chamber 1, the chamber door 50 will return to its original position under the action of the spring piece and the magnet. Specifically, when the transport vehicle body 20 moves out of the inspection chamber 1, the transport vehicle body 20 presses the chamber door 50 from the inside to the outside, and the chamber door 50 and the connecting rod 52 rotate counterclockwise around the connecting rod seat 51, overcoming the upward (or clockwise) elastic force of the spring piece, and the chamber door 50 opens; when the transport vehicle returns to the inspection chamber 1, the upward (or clockwise) elastic force of the spring piece pushes the connecting rod 52 to rotate clockwise around the connecting rod seat 51, and the chamber door 50 closes. The magnets around the chamber door 50 are attracted to the inspection chamber 1 to ensure that the chamber door 50 is tightly closed. Figure 2 The status shown.

[0036] The working process of the present invention is as follows: before the detection, the first motor 210 works to push the transport vehicle body 20 out of the detection chamber 1 (the chamber door 50 is pushed open), and the transport vehicle body 20 reaches the docking position (such as Figure 1 The external conveying mechanism pushes the test tube rack 6 into the conveyor body 20, and the first motor 210 operates to retract the conveyor body 20 into the inspection chamber 1, and the chamber door 50 automatically closes. The conveyor body 20 moves along the slide rail 214, and the test tubes in the test tube rack 6 thereon are aligned with the lens of the photomultiplier tube 3 in sequence. The shutter 40 in front of the lens opens, and optical inspection is completed in sequence. After the inspection is completed, the shutter 40 closes, the conveyor body 20 is pushed out to the docking position, and the external conveying mechanism removes the test tube rack 6 and moves it to the next working position.

[0037] Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the description and implementation methods. They can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to specific details.

Claims

1. An optical detection device, characterized in that: include: An inspection chamber, a conveyor mechanism disposed in the inspection chamber for conveying a test tube rack, a photomultiplier tube for optically inspecting samples in test tubes on the test tube rack, a lens shutter mechanism disposed in the inspection chamber, and a chamber door mechanism disposed on the inspection chamber; The transport vehicle mechanism includes a transport vehicle body, a driving mechanism for driving the transport vehicle body to reciprocate along the Y direction, and a position detection mechanism for detecting the position of the transport vehicle body; The driving mechanism includes a first motor disposed on the detection chamber, a driving pulley connected to the output shaft of the first motor, a driven pulley disposed on the opposite side of the driving pulley along the Y direction, a belt disposed between the driving pulley and the driven pulley, a slide rail disposed on the bottom plate of the detection chamber along the Y direction, and a slider slidably disposed on the slide rail and having one end connected to the belt and the other end connected to the conveyor vehicle body; The door mechanism includes a door, a connecting rod seat, a connecting rod and a reset spring. The side of the detection chamber is provided with an opening for the conveying vehicle body to enter and exit, and the door is provided at the opening; the connecting rod seat is fixedly connected to the bottom surface of the bottom plate of the detection chamber, one end of the connecting rod is rotatably connected to the connecting rod seat, and the other end thereof has an L-shaped connecting portion, and the door is connected to the L-shaped connecting portion; One end of the reset spring sheet covers the connecting rod seat and is fixedly connected to the outer wall of the bottom of the detection chamber, and the other end of the reset spring sheet covers the connecting rod; The door is also provided with a plurality of magnet blocks; The position detection mechanism includes a bar code ruler fixedly connected to the slider, a plurality of position detection grooves arranged on the bar code ruler along the Y direction, and a photoelectric switch for cooperating with the position detection grooves; The conveyor body is provided with a receiving slot for receiving the test tube rack, the test tube rack is inserted into the receiving slot from the front end of the conveyor body, a spring slot is provided at the rear end of the test tube rack, and a clamping spring for cooperating with the spring slot is provided at the rear end of the receiving slot; The bottom of the transport vehicle body is provided with a plurality of through holes corresponding to the positions and quantities of the test tubes on the test tube rack; The clamping spring is U-shaped, the middle portion of the U-shape is fixedly connected to the rear end of the receiving groove, and the two ends of the U-shape protrude inwardly to form a clamping protrusion; A detection hole is opened on the bottom plate of the detection chamber, the photomultiplier tube is arranged below the detection hole, and the lens shutter mechanism includes a shutter arranged at the detection hole and a driving module for driving the shutter to move.

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