A calibration device and method for a multifunctional physiological parameter detection instrument

Abstract

The present invention discloses a calibration device and method for a multifunctional physiological parameter detection instrument, comprising a sealed shell, an arbitrary space walking path controller is fixed in the sealed shell, a functional module is arranged on the arbitrary space walking path controller, an opening is arranged at a position corresponding to the functional module on the sealed shell, and a tissue phantom is arranged in a fixed groove at the opening. The calibration device has a cylindrical shape and is installed in a wrist-shaped mold, a chest-shaped mold or a head-shaped mold to form a wrist-shaped calibration device, a chest-shaped calibration device or a head-shaped calibration device, etc. It can simulate the propagation process of electromagnetic waves in different types of tissues, can assist the development and calibration of some physiological parameter detection instruments, has a simple structure, stable performance, and is convenient to assemble with different modules, and is used to calibrate different optical detection equipment, helping to improve development efficiency and performance.

Description

Technical Field

[0001] The present invention relates to a medical imaging standard device and method, and in particular to a calibration device and method for a multifunctional physiological parameter detection instrument. Background Art

[0002] Glucose, hemoglobin, fat, melanin, bilirubin and other substances in the human body have different absorption effects on electromagnetic waves of different frequencies.

[0003] The principle of electromagnetic wave detection is as follows: electromagnetic waves are incident on tissues, absorbed and scattered by tissues including blood vessels and fat, and then captured by sensors. The obtained electromagnetic spectrum can be used to detect some physiological and pathological parameters, such as heart rate, blood oxygen saturation, blood sugar, blood lipids, etc.

[0004] For example, the heart rate and blood oxygen saturation test instruments based on near-infrared and visible light band electromagnetic waves: the acquired spectral information can be divided into non-pulsating components (mainly caused by the absorption of tissues, bones and other components) and pulsating components (mainly caused by the absorption of hemoglobin in arterial blood), through non-pulsating signals and pulsating signals. In addition, there are obvious differences in the absorption peaks of light for components of hemoglobin with different blood oxygen saturation. The acquired spectrum is processed according to a specific algorithm to realize dynamic heart rate and blood oxygen saturation monitoring.

[0005] Another example is the gastrointestinal motility and infant heart rate testing instrument based on ultrasonic electromagnetic waves: according to the Doppler effect of ultrasound, the dynamic effect of the target tissue in the body can be inferred based on the reflected wave, thereby realizing the detection of infant heart rate and intestinal motility.

[0006] Through similar methods, based on electromagnetic waves of different frequencies, combined with conduction equipment and sensors, it is possible to monitor important physiological parameters such as tissue blood sugar, blood lipids, metabolic rate, etc.

[0007] Due to the differences between human bodies, in order to assist in the development and testing of non-destructive testing instruments based on electromagnetic waves for physiological parameters (such as heart rate, blood oxygen, blood sugar and blood lipids), a standard device that can stably simulate the absorption and scattering processes of different tissue components is needed to help calibrate the performance of these instruments.

[0008] Common methods use functional materials, such as melanin, liposomes, glucose, blood, etc., to prepare a tissue phantom, in which the phantom body has the same optical parameters as the tissue, and with the help of embedded channels (selected according to functional requirements), it can replace the tissue for the development and calibration of physiological and pathological parameter detection instruments.

[0009] However, most of these devices have only a single function, and the preparation process is complicated, and the assembly and debugging are time-consuming and laborious. For example, some phantoms are liquid, and some phantoms used for heart rate calibration require fresh blood, all of which lead to poor stability and portability of the calibration device. Summary of the invention

[0010] The object of the present invention is to provide a calibration device and method for a multifunctional physiological parameter detection instrument.

[0011] The objective of the present invention is achieved through the following technical solutions:

[0012] The calibration device for a multifunctional physiological parameter detection instrument of the present invention comprises a sealed shell, in which an arbitrary space walking path controller is fixed, on which a functional module is arranged, and an opening is arranged at a position corresponding to the functional module on the sealed shell, and a tissue phantom is installed in a fixing groove at the opening.

[0013] The calibration method of the calibration device for the multifunctional physiological parameter detection instrument of the present invention includes any one or more of the following:

[0014] Method 1: A method for calibrating the function of a heart rate diagnostic device using the wrist-shaped calibration device, comprising the steps of:

[0015] According to the heart rate to be simulated, the functional module is designed and prepared, wherein the preparation of the functional module includes casting a mixture of hemoglobin microcapsules as the main material and a light-transmitting polymer resin;

[0016] According to the heart rate parameters to be simulated, complete the setting of controller parameters for the walking path controller in any space;

[0017] Complete the assembly of the portable calibration module and the wrist-shaped housing, place the heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive;

[0018] The space walking path controller drives the functional module to perform periodic motion, resulting in periodic changes in the area of ​​the hemoglobin particles under the sensor;

[0019] Then the spectrum measured by the sensor changes periodically, and the heart rate parameters are calculated based on the measured spectrum;

[0020] According to the calculation results, the calibration of controller parameters and material ratio of functional modules of arbitrary space walking path controller is completed;

[0021] Method 2: The chest-shaped calibration device is used for calibrating the function of a clinical blood glucose detection instrument, comprising the steps of:

[0022] According to the blood sugar parameters to be simulated, the functional module is designed and prepared, wherein the preparation of the functional module includes casting a light-transmissive polymer resin mixed with glucose and a pigment main material;

[0023] Since blood glucose parameters do not have the nature of periodic fluctuations, the functional module does not need to move, and the controller parameters of the arbitrary spatial walking path controller are set so that it is in the corresponding spatial position during calibration;

[0024] Complete the assembly of the portable calibration module and the chest-shaped shell, place the blood oxygen detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive;

[0025] The space walking path controller drives the functional module to the bottom of the sensor and maintains it;

[0026] Calculate the blood oxygen parameters according to the measured spectrum, and complete the calibration of the controller parameters and the material ratio of the functional module of the arbitrary space walking path controller according to the calculation results;

[0027] Method 3: The method of using the chest-shaped calibration device for calibrating the function of an ultrasonic heart rate detection instrument comprises the following steps:

[0028] According to the heart rate parameters to be simulated, the design and preparation of functional modules for ultrasonic rebound characteristics are completed;

[0029] Due to the Doppler effect caused by the periodic beating of the heart based on ultrasound heart rate detection, the controller parameters of the arbitrary space walking path controller are set according to the heart rate parameters to be simulated, so that it performs periodic motion during calibration;

[0030] Complete the assembly of the portable calibration module and the chest-shaped shell, place the ultrasonic heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive;

[0031] The space walking path controller drives the functional module to do periodic motion, causing the distance between the sensor and the functional module to change periodically;

[0032] Then the sensor measures the ultrasound spectrum and uses it as a basis to calculate the heart rate parameters;

[0033] According to the calculation results, the calibration of controller parameters of arbitrary space walking path controller and the material ratio of functional modules is completed.

[0034] It can be seen from the technical solution provided by the present invention that the calibration device and method for a multifunctional physiological parameter detection instrument provided in the embodiment of the present invention have a simple structure, stable performance, and are convenient to assemble with different modules. They are used to calibrate different optical detection equipment, helping to improve development efficiency and performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 A schematic diagram of the exploded structure of a calibration device for a multifunctional physiological parameter detection instrument provided by an embodiment of the present invention;

[0036] Figure 2 Workflow diagram of the calibration device for a multifunctional physiological parameter detection instrument provided by an embodiment of the present invention

[0037] Figure 3 A schematic diagram of a wrist-shaped calibration device according to an embodiment of the present invention;

[0038] Figure 4 Schematic diagram of a chest-shaped calibration device according to an embodiment of the present invention.

[0039] In the figure:

[0040] 1. Sealing shell, 2. Fixing plate, 3. Functional module, 4. Tissue phantom, 5. Connecting rod, 6. Arbitrary space walking path controller, 7. Universal joint, 8. Guide rod, 9. Fixed bracket, 10. Guide rod fixing groove, 11. Fixed shell, 12. Wrist mold, 13. Thoracic mold, 14. Fixing device, 15. Calibration device. DETAILED DESCRIPTION

[0041] The embodiments of the present invention will be described in further detail below. The contents not described in detail in the embodiments of the present invention belong to the prior art known to those skilled in the art.

[0042] The calibration device and method for a multifunctional physiological parameter detection instrument of the present invention, the preferred specific implementation method is:

[0043] The calibration device for a multifunctional physiological parameter detection instrument of the present invention comprises a sealed shell, in which an arbitrary space walking path controller is fixed, on which a functional module is arranged, and an opening is arranged at a position corresponding to the functional module on the sealed shell, and a tissue phantom is installed in a fixing groove at the opening.

[0044] The arbitrary space walking path controller includes two upper and lower annular fixed brackets, the upper and lower fixed brackets are connected together by at least three guide rods, each guide rod is provided with a slider, the functional module is fixed on a fixed plate, and the slider is connected to the fixed plate by a connecting rod and a universal joint;

[0045] The guide rod is fixed in a guide rod fixing groove on the inner wall of the sealing shell, and the fixing plate is provided with a driving source.

[0046] The tissue phantom is prepared by casting a polymer material with light permeability, electromagnetic wave absorption and scattering properties.

[0047] The functional module is made of a material with stable electromagnetic wave absorption and scattering properties.

[0048] The preparation materials of the functional module include any one or more of the following: hemoglobin capsule, glucose, liposome, chromophore, pigment.

[0049] The sealed shell comprises a fixed shell and a sealed shell which are buckled together.

[0050] The driving source includes any one of the following: a motor, a cylinder, a hydraulic cylinder, and an electromagnetic device.

[0051] The calibration device is cylindrical in shape and is installed in a wrist-shaped mold, a chest-shaped mold or a head-shaped mold to form a wrist-shaped calibration device, a chest-shaped calibration device or a head-shaped calibration device.

[0052] The calibration method of the calibration device for the multifunctional physiological parameter detection instrument of the present invention includes any one or more of the following:

[0053] Method 1: A method for calibrating the function of a heart rate diagnostic device using the wrist-shaped calibration device, comprising the steps of:

[0054] According to the heart rate to be simulated, the functional module is designed and prepared, wherein the preparation of the functional module includes casting a mixture of hemoglobin microcapsules as the main material and a light-transmitting polymer resin;

[0055] According to the heart rate parameters to be simulated, complete the setting of controller parameters for the walking path controller in any space;

[0056] Complete the assembly of the portable calibration module and the wrist-shaped housing, place the heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive;

[0057] The space walking path controller drives the functional module to perform periodic motion, resulting in periodic changes in the area of ​​the hemoglobin particles under the sensor;

[0058] Then the spectrum measured by the sensor changes periodically, and the heart rate parameters are calculated based on the measured spectrum;

[0059] According to the calculation results, the calibration of controller parameters and material ratio of functional modules of arbitrary space walking path controller is completed;

[0060] Method 2: The chest-shaped calibration device is used for calibrating the function of a clinical blood glucose detection instrument, comprising the steps of:

[0061] According to the blood sugar parameters to be simulated, the functional module is designed and prepared, wherein the preparation of the functional module includes casting a light-transmissive polymer resin mixed with glucose and a pigment main material;

[0062] Since blood glucose parameters do not have the nature of periodic fluctuations, the functional module does not need to move, and the controller parameters of the arbitrary spatial walking path controller are set so that it is in the corresponding spatial position during calibration;

[0063] Complete the assembly of the portable calibration module and the chest-shaped shell, place the blood oxygen detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive;

[0064] The space walking path controller drives the functional module to the bottom of the sensor and maintains it;

[0065] Calculate the blood oxygen parameters according to the measured spectrum, and complete the calibration of the controller parameters and the material ratio of the functional module of the arbitrary space walking path controller according to the calculation results;

[0066] Method 3: The method of using the chest-shaped calibration device for calibrating the function of an ultrasonic heart rate detection instrument comprises the following steps:

[0067] According to the heart rate parameters to be simulated, the design and preparation of functional modules for ultrasonic rebound characteristics are completed;

[0068] Due to the Doppler effect caused by the periodic beating of the heart based on ultrasound heart rate detection, the controller parameters of the arbitrary space walking path controller are set according to the heart rate parameters to be simulated, so that it performs periodic motion during calibration;

[0069] Complete the assembly of the portable calibration module and the chest-shaped shell, place the ultrasonic heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive;

[0070] The space walking path controller drives the functional module to do periodic motion, causing the distance between the sensor and the functional module to change periodically;

[0071] Then the sensor measures the ultrasound spectrum and uses it as a basis to calculate the heart rate parameters;

[0072] According to the calculation results, the calibration of controller parameters of arbitrary space walking path controller and the material ratio of functional modules is completed.

[0073] The calibration device and method for a multifunctional physiological parameter detection instrument of the present invention can simulate the propagation process of electromagnetic waves in different types of tissues, and can assist in the development and calibration of some physiological parameter detection instruments. The present invention does not involve liquid, has a simple structure, stable performance, and is convenient to assemble with different modules, and is used to calibrate different optical detection equipment, helping to improve development efficiency and performance.

[0074] The multifunctional device of the present invention is used for calibrating instruments for detecting physiological parameters such as heart rate, blood oxygen, blood lipids, blood sugar, gastrointestinal motility, etc. The overall structure is as follows Figure 1 As shown:

[0075] The main components include: a fixed shell, a sealing shell, a functional module, a tissue phantom, and an arbitrary space walking path controller, wherein the arbitrary space walking path controller is composed of a fixed bracket, a slider, a guide rod, a universal joint and a fixed plate.

[0076] The arbitrary space walking path controller is composed of a fixed bracket with guide rods, connecting rods and universal joints as tools, and any power generating device such as motors, cylinders, hydraulic cylinders, electromagnetics, etc. as the driving source. It controls the fixed plate carrying the functional modules to complete the walking of any periodic or non-periodic space path according to the control plan.

[0077] The tissue phantom is made of a mixture of light-transmitting polymer materials and absorption and scattering materials, and has optical parameters similar to those of tissue. The size of the phantom can be flexibly adjusted according to the area of ​​the optical module in the instrument, and can be stably assembled to the integrated device through the fixing groove on the shell.

[0078] The functional modules are made of materials with stable electromagnetic wave absorption and scattering properties, such as hemoglobin capsules, glucose of different concentrations, liposomes, chromophores, pigments, etc.

[0079] For non-dynamic characteristics that need to be simulated, the platform in the space walking path controller is kept stationary; for dynamic characteristics that need to be simulated, the space walking path controller drives the platform to drive the functional modules to make periodic changes, and the change rules are the same as the change rules of the dynamic physiological parameters that need to be simulated.

[0080] Using the guide rod fixing grooves in the fixed shell and the sealing shell as positioning devices, the assembly of the arbitrary space walking path controller module, the functional module and the tissue phantom is completed to obtain the final multifunctional detection instrument calibration device.

[0081] This device is small in size and highly portable. It can be quickly assembled into wrist-shaped, chest-shaped, or head-shaped molds for testing and calibration of different instruments.

[0082] Advantages and positive effects of the present invention:

[0083] The device is entirely solid-state and simple in composition, can be easily mass-produced, is easy to operate, is portable, and is easy to promote.

[0084] The multifunctional testing instrument calibration device has a cylindrical shape and can be easily adjusted in direction to meet the requirements of different testing instruments.

[0085] With the help of an arbitrary spatial path walking controller, the device can simulate a variety of static and dynamic physiological parameters of tissues with stable performance and high repeatability.

[0086] The device can produce phantoms with different optical parameters for different types of tissues, making it more applicable. Specific embodiment:

[0088] The present invention can be further described by the following examples, however, the scope of the present invention is not limited to the following examples. Those engaged in the profession will understand that various changes and modifications can be made to the present invention without departing from the spirit and scope of the present invention.

[0089] Embodiment 1: Wrist-shaped calibration device:

[0090] Together with the wrist-shaped housing, it forms a device for calibrating the function of the heart rate diagnostic device, such as Figure 3 As shown, the process flow is as follows Figure 2 The specific words are as follows:

[0091] According to the heart rate that needs to be simulated, the functional modules are designed and prepared, such as using hemoglobin microcapsules as the main material and mixing them with light-transmitting polymer resin for casting.

[0092] According to the heart rate parameters that need to be simulated, complete the setting of the controller parameters of the arbitrary space walking path controller.

[0093] Complete the assembly of the portable calibration module and the wrist-shaped housing, place the heart rate detection instrument in the middle area of ​​the phantom part of the device, and turn on the spatial walking path controller drive.

[0094] The space walking path controller drives the functional module to perform periodic motion, resulting in periodic changes in the area of ​​the hemoglobin particles under the sensor.

[0095] Then the spectrum measured by the sensor changes periodically, and the heart rate parameters are calculated based on the measured spectrum;

[0096] According to the calculation results, the calibration of controller parameters of arbitrary space walking path controller and the material ratio of functional modules is completed.

[0097] Used to assist in the development of heart rate monitoring equipment.

[0098] Embodiment 2: A device for calibrating the function of a clinical blood glucose detection instrument formed with a chest-shaped housing:

[0099] like Figure 4 The specific words are as follows:

[0100] According to the blood sugar parameters that need to be simulated, the design and preparation of functional modules are completed, such as casting a mixed light-transmitting polymer resin with glucose and pigment as the main materials.

[0101] Since blood glucose parameters do not have the property of periodic fluctuation, the functional module does not need to move, and the controller parameters of the arbitrary spatial walking path controller are set so that it is in the corresponding spatial position during calibration.

[0102] Complete the assembly of the portable calibration module and the chest-shaped shell, place the blood oxygen detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive.

[0103] The space walking path controller drives the functional module to the bottom of the sensor and maintains it.

[0104] The blood oxygen parameters are calculated according to the measured spectrum, and the calibration of the controller parameters of the arbitrary space walking path controller and the material ratio of the functional module is completed according to the calculation results.

[0105] Used to assist in the development of blood glucose testing instruments.

[0106] Embodiment 3: A device for calibrating the function of an ultrasonic heart rate detection instrument formed with a chest-shaped housing:

[0107] like Figure 4 The specific words are as follows:

[0108] According to the heart rate parameters that need to be simulated, the design and preparation of functional modules for ultrasonic rebound characteristics are completed.

[0109] Due to the Doppler effect caused by the periodic beating of the heart based on ultrasound heart rate detection, the controller parameters of the arbitrary space walking path controller are set according to the heart rate parameters to be simulated, so that it performs periodic motion during calibration.

[0110] Complete the assembly of the portable calibration module and the chest-shaped shell, place the ultrasonic heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the space walking path controller drive.

[0111] The space walking path controller drives the functional module to do periodic motion, resulting in a periodic change in the distance between the sensor and the functional module.

[0112] Then the sensor measures the ultrasound spectrum and uses it as a basis to calculate the heart rate parameters;

[0113] According to the calculation results, the calibration of controller parameters of arbitrary space walking path controller and the material ratio of functional modules is completed.

[0114] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed in the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A calibration method for a multifunctional physiological parameter detection instrument, implemented by a calibration device for a multifunctional physiological parameter detection instrument, characterized in that: The calibration device for the multifunctional physiological parameter detection instrument comprises a sealed housing, an arbitrary space walking path controller is fixed in the sealed housing, a functional module is arranged on the arbitrary space walking path controller, an opening is arranged at a position corresponding to the functional module on the sealed housing, and a tissue phantom is arranged in a fixing groove at the opening; The arbitrary space walking path controller includes two upper and lower annular fixed brackets, the upper and lower fixed brackets are connected together by at least three guide rods, each guide rod is provided with a slider, the functional module is fixed on a fixed plate, and the slider is connected to the fixed plate by a connecting rod and a universal joint; The guide rod is fixed in a guide rod fixing groove on the inner wall of the sealing housing, and the fixing plate is provided with a driving source; The calibration device is cylindrical in shape and is installed in a wrist-shaped mold, a chest-shaped mold or a head-shaped mold to form a wrist-shaped calibration device, a chest-shaped calibration device or a head-shaped calibration device; This includes any one or more of the following methods: Method 1: A method for calibrating the function of a heart rate diagnostic device using the wrist-shaped calibration device, comprising the steps of: According to the heart rate to be simulated, the functional module is designed and prepared, wherein the preparation of the functional module includes casting a mixture of hemoglobin microcapsules as the main material and a light-transmitting polymer resin; According to the heart rate parameters to be simulated, complete the setting of the controller parameters for the walking path in any space; Complete the assembly of the portable calibration module and the wrist-shaped housing, place the heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the arbitrary space walking path controller drive; The arbitrary space walking path controller drives the functional module to perform periodic motion, resulting in periodic changes in the area of ​​the hemoglobin particles under the sensor; Then the spectrum measured by the sensor changes periodically, and the heart rate parameters are calculated based on the measured spectrum; According to the calculation results, the calibration of the parameters of the arbitrary space walking path controller and the proportion of functional module materials is completed; Method 2: A method for using the chest-shaped calibration device for functional calibration of a clinical blood glucose detection instrument, comprising the steps of: According to the blood sugar parameters to be simulated, the functional module is designed and prepared, wherein the preparation of the functional module includes casting a light-transmissive polymer resin mixed with glucose and a pigment main material; Since blood glucose parameters do not have the nature of periodic fluctuations, the functional module does not need to move, and the parameters of the arbitrary spatial walking path controller are set so that it is in the corresponding spatial position during calibration; Complete the assembly of the portable calibration module and the chest-shaped shell, place the blood oxygen detection instrument in the middle area of ​​the phantom part of the device, and start the arbitrary space walking path controller drive; The arbitrary space walking path controller drives the functional module to the bottom of the sensor and maintains it; The blood oxygen parameters are calculated based on the measured spectrum, and the calibration of the parameters of the arbitrary space walking path controller and the proportion of the functional module materials is completed based on the calculation results; Method 3: The method of using the chest-shaped calibration device for calibrating the function of an ultrasonic heart rate detection instrument comprises the following steps: According to the heart rate parameters to be simulated, the design and preparation of functional modules for ultrasonic rebound characteristics are completed; Due to the Doppler effect caused by the periodic beating of the heart based on ultrasound heart rate detection, the parameters of the arbitrary space walking path controller are set according to the heart rate parameters to be simulated, so that it performs periodic motion during calibration; Complete the assembly of the portable calibration module and the chest-shaped shell, place the ultrasonic heart rate detection instrument in the middle area of ​​the phantom part of the device, and start the arbitrary space walking path controller drive; The arbitrary space walking path controller drives the functional module to do periodic motion, causing the distance between the sensor and the functional module to change periodically; Then the sensor measures the ultrasound spectrum and uses it as a basis to calculate the heart rate parameters; According to the calculation results, the calibration of the controller parameters of any space walking path and the material ratio of the functional module is completed.

2. The calibration method for a multifunctional physiological parameter detection instrument according to claim 1, characterized in that: The tissue phantom is prepared by casting a polymer material with light permeability, electromagnetic wave absorption and scattering properties.

3. The calibration method for a multifunctional physiological parameter detection instrument according to claim 2, characterized in that: The functional module is made of a material with stable electromagnetic wave absorption and scattering properties.

4. The calibration method for a multifunctional physiological parameter detection instrument according to claim 3, characterized in that: The preparation materials of the functional module include any one or more of the following: hemoglobin capsule, glucose, liposome, chromophore, pigment.

5. The calibration method for a multifunctional physiological parameter detection instrument according to claim 4, characterized in that: The sealed shell comprises a fixed shell and a sealed shell which are buckled together.

6. The calibration method for a multifunctional physiological parameter detection instrument according to claim 5, characterized in that: The driving source includes any one of the following: a motor, a cylinder, a hydraulic cylinder, and an electromagnetic device.

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