A delivery tube of a tissue clamping device and a valve repair device

Abstract

The embodiment of this specification discloses a delivery tube of a tissue clamping device and a valve repair device. The delivery tube of the tissue clamping device includes an outer tube, an inner core and a traction mechanism; the outer tube is sleeved outside the inner core; the outer tube includes a first tube body and a second tube body, one end of the first tube body is connected to the tissue clamping device, and the other end of the first tube body is connected to the second tube body; the traction mechanism is used to control the bending of the first tube body.

Description

Technical Field

[0001] The embodiments of the present specification relate to the technical field of medical equipment, and in particular to a delivery tube of a tissue clamping device and a valve repair device. Background Art

[0002] A valve is a membrane-like structure that can be opened and closed inside the organs of humans or certain animals. For example, each person has four valves in their heart, namely the aortic valve, pulmonary valve, mitral valve, and tricuspid valve. Taking the mitral valve as an example, the mitral valve is located between the left atrium and the left ventricle. When the left ventricle contracts, the mitral valve acts as a check valve to tightly close the atrioventricular orifice to prevent blood from flowing back from the left ventricle into the left atrium. However, when the mitral valve is diseased, it may be difficult to close completely when the left ventricle contracts, causing the left atrium to receive a large amount of reflux blood, which may cause a sharp increase in left atrium and pulmonary venous pressure, increase the left ventricular diastolic volume load, and further lead to a series of pathological changes such as left ventricular enlargement and pulmonary hypertension, ultimately leading to clinical manifestations such as heart failure and arrhythmia, which can be life-threatening in severe cases. When repairing a diseased mitral valve, the valve repair device can be used to clamp the opposite side of the mitral valve, so that the hole between the mitral valves changes from one large hole to two small holes, reducing the regurgitation area, thereby effectively preventing the occurrence of mitral valve regurgitation. Similarly, the valve repair device can also be used to repair other valves such as the tricuspid valve of the heart, by clamping the leaflets on both sides to achieve the effect of reducing the regurgitation area. The valve repair device includes a delivery tube, which can be used to deliver the tissue clamping device during the valve repair process. Summary of the invention

[0003] One aspect of an embodiment of the present specification provides a delivery tube for a tissue clamping device, comprising an outer tube, an inner core and a traction mechanism; the outer tube is sleeved on the outside of the inner core; the outer tube comprises a first tube body and a second tube body, one end of the first tube body is connected to the tissue clamping device, and the other end of the first tube body is connected to the second tube body; the traction mechanism is used to control the bending of the first tube body.

[0004] In some embodiments, a plurality of notches are formed on one side of the first tube along its length direction, and the first tube can be bent toward the opening directions of the plurality of notches.

[0005] In some embodiments, the diameters of the plurality of notches are the same or different.

[0006] In some embodiments, the diameter of the notch near the one end of the first tube is smaller than the diameter of the notch near the other end of the first tube.

[0007] In some embodiments, the first tube body is cut and formed in one piece from a shape memory alloy tube.

[0008] In some embodiments, the traction mechanism includes a traction wire, one end of which is fixedly connected to one end of the first tube body; a groove is provided on one side of the inner core along its length direction, and the traction wire is arranged in the groove.

[0009] In some embodiments, the traction mechanism further includes a spring tube, and the spring tube is sleeved on the portion of the traction wire corresponding to the second tube body.

[0010] In some embodiments, the traction mechanism further includes a blocking member, which is sleeved on the traction wire and fixed at the connection between the first tube body and the second tube body to form a blockage for the spring tube.

[0011] In some embodiments, a connecting piece is provided at the connection between the first tube body and the second tube body, and the blocking piece is fixedly connected to the connecting piece.

[0012] In some embodiments, the one end of the first tube is connected to the tissue clamping device via a delivery connection.

[0013] In some embodiments, a through hole is provided inside the inner core for the control rod and / or control cable of the tissue clamping device to pass through.

[0014] In some embodiments, the second tube body is a mesh woven structure.

[0015] In some embodiments, the outer surface of the outer tube is further provided with a heat-shrinkable polyether block polyamide material layer.

[0016] One aspect of an embodiment of the present specification provides a valve repair device, comprising a delivery tube of a tissue clamping device as described in any embodiment of the present application.

[0017] In some embodiments, the valve repair device includes a control handle, and the control handle includes a delivery tube control mechanism, and the delivery tube control mechanism is used to control the bending of the first tube body of the delivery tube.

[0018] In some embodiments, the conveying tube control mechanism includes a screw, a rotating part and a traction part; the screw and the traction part are threadedly connected; the rotating part is used to drive the screw to rotate and thereby drive the traction part to move; the movement of the traction part can control the bending of the first tube body through the traction mechanism.

[0019] In some embodiments, the valve repair device includes a tissue clamping device, which includes an outer clamping arm and an inner clamping arm, and the valve can be clamped between the outer clamping arm and the inner clamping arm; the control handle includes an outer clamping arm control mechanism and an inner clamping arm control mechanism, the outer clamping arm control mechanism is used to control the opening and closing of the outer clamping arm, and the inner clamping arm control mechanism is used to control the opening and closing of the inner clamping arm relative to the outer clamping arm; the tissue clamping device is connected to the control handle through the delivery tube.

[0020] In some embodiments, the outer clamp arm control mechanism includes a sleeve, a first control part and a sliding part, and the sliding part is arranged in the sleeve; the first control part can drive the sliding part to move in the sleeve along the length direction of the sleeve by rotation to control the opening and closing of the outer clamp arm.

[0021] In some embodiments, the inner clamp arm control mechanism includes a shell and a second control part; a second slide groove is opened on the shell; the second control part passes through the second slide groove and can move along the second slide groove to control the opening and closing of the inner clamp arm relative to the outer clamp arm.

[0022] In some embodiments, the valve repair device further comprises a support tube; and the control handle is used to transport the tissue clamping device to the valve to be repaired through the support tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] This specification will be further described in the form of exemplary embodiments, which will be described in detail by the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same number represents the same structure, wherein:

[0024] Figure 1 is a schematic diagram of the structure of a delivery tube of a tissue clamping device according to some embodiments of the present application;

[0025] Figure 2 An exploded schematic diagram of a delivery tube of a tissue clamping device according to some embodiments of the present application;

[0026] Figure 3 According to some embodiments of the present application Figure 2 A partial enlarged view of the connection between the blocking member and the spring tube shown in ;

[0027] Figure 4 is a schematic structural diagram of a first tube body according to some embodiments of the present application;

[0028] Figure 5 is a schematic structural diagram of a first tube body from another perspective according to some embodiments of the present application;

[0029] Figure 6is a schematic structural diagram of a second tube body according to some embodiments of the present application;

[0030] Figure 7 is a schematic diagram of the structure of a valve repair device according to some embodiments of the present application;

[0031] Figure 8 is a schematic diagram of the structure of a delivery connector and a tissue clamping device according to some embodiments of the present application;

[0032] Fig. 9 is a schematic diagram of the structure of a conveying connection according to some embodiments of the present application;

[0033] Fig.10 is a schematic structural diagram of an outer clamping arm of a tissue clamping device in an open state according to some embodiments of the present application;

[0034] Fig.11 is a schematic diagram of an exploded structure of a delivery pipe control mechanism according to some embodiments of the present application;

[0035] Fig.12 is a schematic diagram of a partial cross-sectional structure of an outer clamp arm control mechanism according to some embodiments of the present application;

[0036] Fig.13 is a schematic diagram of the structure of a sleeve according to some embodiments of the present application;

[0037] Fig.14 is a schematic diagram of the exploded structure of the sliding part and the protective cover according to some embodiments of the present application;

[0038] Fig.15 is a partial cross-sectional structural schematic diagram of an inner clamp arm control mechanism according to some embodiments of the present application;

[0039] Fig.16 is a schematic diagram of a housing according to some embodiments of the present application;

[0040] Fig.17 is a schematic diagram of the structure of a second control unit according to some embodiments of the present application;

[0041] Fig.18 is a structural schematic diagram of a second control unit and a locking mechanism at a first viewing angle according to some embodiments of the present application; and

[0042] Fig.19 It is a structural schematic diagram of the second control unit and the locking mechanism at a second viewing angle according to some embodiments of the present application.

[0043] In the figure: 1000-valve repair device; 100-transport tube; 110-outer tube; 111-first tube body; 1110-notch; 1111-first fixing part; 1112-second fixing part; 112-second tube body; 120-inner core; 121-groove; 122-through hole; 130-traction mechanism; 131-traction wire; 132-spring tube; 133-blocking member; 140-transport connecting member ; 142-main body; 144-first connecting piece; 146-second connecting piece; 148-fixing rod; 150-connecting piece; 200-tissue clamping device; 210-inner clamping arm; 211-first inner clamping arm; 213-second inner clamping arm; 215-barb; 220-outer clamping arm; 221-first outer clamping arm; 223-second outer clamping arm; 230-first fixing piece; 240-supporting part; 250- The second fixing member; 260-outer clamping plate; 261-first outer clamping plate; 263-second outer clamping plate; 300-control handle; 400-outer clamping arm control mechanism; 410-sleeve; 412-first slide groove; 420-first control part; 421-connecting groove; 429-connecting block; 430-sliding part; 440-control rod; 460-fixed block; 470-protective cover; 500-inner clamping arm control mechanism; 510-housing; 511-second slide groove; 520-second control part; 521-conduit; 523-end cover; 530-locking mechanism; 531-elastic member; 533-locking button; 535-locking block; 537-toothed connecting part; 600-conveying pipe control mechanism; 610-screw; 620-rotating part; 630-traction part; 635-threaded traction block; 640-bending indication device. DETAILED DESCRIPTION

[0044] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0045] On the contrary, the present application covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present application as defined by the claims. Further, in order to make the public have a better understanding of the present application, some specific details are described in detail in the detailed description of the present application below. Those skilled in the art can fully understand the present application without the description of these details.

[0046] Embodiments of the present application relate to a delivery tube of a tissue clamping device and a valve repair device. The valve repair device can be used to repair heart valves (such as mitral valves, tricuspid valves, etc.) or other valves. The valve repair device includes a tissue clamping device. The tissue clamping device can be used to clamp the valve to achieve valve repair. The delivery tube can be used to fix and transport the tissue clamping device. In some embodiments, the tissue clamping device can reach a predetermined position through a specific path. For example, the tissue clamping device can be delivered to the mitral valve via the femoral vein, inferior vena cava, right atrium, and left atrium to repair the mitral valve.

[0047] In some embodiments, the delivery tube of the tissue clamping device disclosed in the present application can also be applied to other types of interventional medical devices. For example, the delivery tube can also be applied to cardiac interventional devices, nervous system interventional devices, vascular interventional devices, and artificial insemination devices. Interventional medical devices including delivery tubes can be applied to valve repair surgery, heart stent surgery, puncture surgery, drug infusion surgery, vascular embolization surgery, and artificial insemination surgery. In some alternative embodiments, the delivery tube can also be applied to other medical devices or other technical fields (such as detection instruments).

[0048] Figure 1 is a schematic diagram of the structure of a delivery tube of a tissue clamping device according to some embodiments of the present application; Figure 2 is an exploded schematic diagram of a delivery tube of a tissue clamping device according to some embodiments of the present application; Figure 3 According to some embodiments of the present application Figure 2 A partial enlarged view of the connection between the blocking member and the spring tube shown in ; Figure 4 is a schematic structural diagram of a first tube body according to some embodiments of the present application; Figure 5 is a schematic structural diagram of a first tube body from another perspective according to some embodiments of the present application; Figure 6 is a schematic diagram of the structure of the second tube body according to some embodiments of the present application. Figure 1-6 The delivery tube of the tissue clamping device involved in the embodiment of the present application is described in detail. It should be noted that the following embodiments are only used to explain the present application and do not constitute a limitation of the present application.

[0049] like Figure 1-6As shown, the delivery tube 100 may include an outer tube 110, an inner core 120 and a traction mechanism 130. The outer tube 110 is sleeved on the outside of the inner core 120. In some embodiments, the delivery tube 100 may further include a delivery connector 140. The delivery tube 100 may be detachably connected to the tissue clamping device through the delivery connector 140. In some embodiments, the outer tube 110 may include a first tube body 111 and a second tube body 112. One end of the first tube body 111 is connected to the tissue clamping device, and the other end of the first tube body 111 is connected to the second tube body 112. Specifically, the first tube body 111 may be located at the front end of the delivery tube 100 (i.e., the end close to the tissue clamping device), and the second tube body 112 may be located at the rear end of the delivery tube 100 (i.e., the end away from the tissue clamping device), and the first tube body 111 and the second tube body 112 are connected end to end. In some embodiments, as Figure 2-3 As shown, the other end of the first tube 111 can be connected to the second tube 112 through a connector 150. In some alternative embodiments, the other end of the first tube 111 can also be directly connected to the second tube 112. In some embodiments, the first tube 111 can be provided with a first fixing portion 1111 and a second fixing portion 1112 at both ends, respectively. The first fixing portion 1111 and the second fixing portion 1112 can be integrally formed with the first tube 111. The first tube 111 and the transport connector 140 can be connected (such as clamping) through the first fixing portion 1111, and the first tube 111 can be connected (such as clamping) with the connector 150 through the second fixing portion 1112. In some embodiments, the end of the second tube 112 away from the first tube 111 can be connected to a control handle. In some embodiments, one or more through holes 122 can be provided inside the inner core 120 for the control cable and / or control rod of the tissue clamping device to pass through. In some embodiments, the inner core 120 can be made of an elastic material (such as nylon, silicone, heat-shrinkable polyether block polyamide (Pebax), polytetrafluoroethylene (PTFE) material) so that the inner core 120 has a certain elasticity, so that when the outer tube 110 bends, it can drive the inner core 120 to bend.

[0050] In some embodiments, the traction mechanism 130 can be used to control the bending of the first tube 111. In some embodiments, the traction mechanism 130 may include a traction wire 131, one end of which is fixedly connected to one end (such as the front end) of the first tube 111. For example, one end of the traction wire 131 can be fixedly connected to the first fixing portion 1111 or other parts of the first tube 111 by welding, gluing, clamping, etc. In some alternative embodiments, one end of the traction wire 131 can also be fixedly connected to the inner core 120. The other end of the traction wire 131 can be connected to the conveying tube control mechanism, and the conveying tube control mechanism can control the bending of the first tube 111 by pulling or loosening the traction wire 131. In some embodiments, a groove 121 is provided on one side of the inner core 120 along its length direction, and the traction wire 131 is arranged in the groove 121. The groove 121 can limit the position of the traction wire 131, prevent the traction wire 131 from tilting or winding between the outer tube 110 and the inner core 120, so as to ensure that the traction wire 131 accurately controls the bending direction and bending degree of the first tube 111. In some embodiments, the traction mechanism 130 may further include a spring tube 132, which is sleeved on the corresponding part of the traction wire 131 and the second tube 112. When the delivery tube control mechanism pulls and tightens the traction wire 131, the traction wire 131 drives the first tube 111 to bend. Since the spring tube 132 is sleeved on the corresponding part of the traction wire 131 and the second tube 112, the spring tube 132 will generate stress that hinders the bending of the second tube 112, thereby reducing the influence of the traction wire 131 on the second tube 112, so that the traction wire 131 is mainly used to control the bending of the first tube 111. In some embodiments, according to the different bending requirements of the first tube 111 and the second tube 112, spring tubes 132 with different elastic coefficients can be set. In some embodiments, the traction wire may include a steel wire rope, a nanowire, a glass rope, etc., which is not limited in the present application.

[0051] In some embodiments, one end of the spring tube 132 can be directly fixedly connected to the outer tube 110 (the second tube body 112 or the connection between the first tube body 111 and the second tube body 112) or the inner core 120. At this time, the connection between the outer tube 110 or the inner core 120 and the spring tube 132 can limit and block the spring tube 132. In some embodiments, the traction mechanism 130 can also include a blocking member 133, which is sleeved on the traction wire 131 and fixedly arranged at the connection between the first tube body 111 and the second tube body 112 to form a blockage for the spring tube 132. In some embodiments, the blocking member 133 can be a cylindrical structure having a through hole ( Figure 3(not shown), the traction wire 131 can pass through the through hole and can move in the through hole of the blocking member 133. One end of the spring tube 132 is abutted or fixedly connected to the blocking member 133. The diameter of the spring tube 132 is larger than the through hole of the blocking member 133, so that the spring tube 132 cannot move relative to the blocking member 133. In some embodiments, the blocking member 133 can also limit the traction wire 131 to prevent the traction wire 131 from deviating relative to the groove 121. It should be noted that the blocking member 133 is not limited to Figure 2 and Figure 3 The cylindrical structure shown in the figure, as long as other structures can block the spring tube 132 from moving in the length direction of the inner core, can be regarded as the blocking member 133 in the embodiment of this specification.

[0052] In some embodiments, a connector 150 is provided at the connection between the first tube body 111 and the second tube body 112, and the two ends of the connector 150 are respectively connected to the second fixing portion 1112 of the first tube body 111 and the end of the second tube body 112 (such as clamping, abutting, fixed connection, etc.). For example, the outer surface of the outer tube 110 can be provided with a polymer material layer (such as a heat-shrinkable polyether block polyamide (Pebax) material layer). During the preparation process, the polymer material layer on the outer surface of the first tube body 111, the connector 150 and the second tube body 112 is in a molten state at high temperature, and after cooling, the first tube body 111, the connector 150 and the second tube body 112 can be fixedly connected. In some embodiments, the blocking member 133 can be fixedly connected to the connector 150 (such as welding, gluing, etc.). In some embodiments, the blocking member 133 can also be integrally formed with the connector 150. In some alternative embodiments, the blocking member 133 can also be fixedly connected to the inner core 120.

[0053] In some embodiments, a plurality of notches 1110 are provided on one side of the first tube 111 along its length direction, and the first tube 111 can be bent in the direction of the openings of the plurality of notches 1110. By providing the plurality of notches 1110, the first tube 111 can be easily bent, and the first tube 111 can be bent in a specific direction. In this embodiment, the plurality of notches 1110 are provided on one side of the first tube 111, so that the first tube 111 can be bent in the direction of the openings of the notches. Specifically, one side of the opening direction of the plurality of notches 1110 can be the same as the side on which the grooves 121 on the inner core 120 are provided. In other embodiments, the plurality of notches 1110 can also be provided at intervals on different sides of the first tube 111. In this case, the corresponding different sides of the inner core 120 can all be provided with grooves, and the traction mechanism 130 can include corresponding multiple traction wires, so that the first tube 111 can be bent in different directions under the control of different traction wires. In some embodiments, the first tube 111 can be integrally cut and formed from a stainless steel (such as 316 stainless steel) or shape memory alloy (such as nickel-titanium alloy) tube.

[0054] In some embodiments, the calibers of the multiple notches 1110 may be exactly the same, and each part of the first tube 111 has the same bending ability. Among them, the notch caliber can be understood as the distance between the two sides of the opening end of the notch. In some embodiments, the calibers of the multiple notches 1110 may not be exactly the same, so that each part of the first tube 111 has different bending abilities. For example, when the force of the traction wire 131 is constant, the larger the caliber of the notch 1110, the greater the bending degree of the first tube 111; the smaller the caliber of the notch 1110, the smaller the bending degree of the first tube 111. In some embodiments, the caliber of the notch 1110 near one end of the tissue clamping device of the first tube 111 is smaller than the caliber of the notch 1110 near the other end of the first tube 111 (the end connected to the second tube 112). When the traction wire 131 is tightened, the traction wire 131 drives the first tube 111 to bend. Since the notch 1110 at one end of the first tube 111 close to the tissue clamping device has a smaller diameter, the bending degree of the first tube 111 at this end is also smaller, while the bending degree of the first tube at the other end is relatively larger. This arrangement can make it easier for the tissue clamping device to be aligned with the target area (such as the heart valve to be repaired).

[0055] In some embodiments, the second tube 112 can be a mesh braided structure. On the one hand, the mesh braided structure has good torque control performance. When the control handle is rotated, the second tube 112 can transmit the torque of the control handle to drive the first tube 111 to rotate. On the other hand, the mesh braided structure has good anti-extrusion and anti-bending capabilities. When the delivery tube 100 enters human tissue (such as blood vessels, atrial walls, etc.), the second tube 112 composed of the mesh braided structure can withstand the extrusion of human tissue, so that the second tube 112 maintains a normal shape. In addition, when the traction wire 131 is tightened, the traction wire 131 drives the outer tube 110 (the first tube 111 and the second tube 112) and the inner core 120 to bend. The second tube 112 has a higher anti-bending ability, which can make the traction wire 131 have a smaller bending effect on the second tube 112, so that the traction wire 131 can better control the bending of the first tube 111.

[0056] In some embodiments, the outer surface of the outer tube 110 (the first tube body 111 and the second tube body 112) may be provided with a thermoplastic material layer. For example, the thermoplastic material may include polyether block polyamide (PEPAX), polyurethane, polyamide, polyimide, polyethylene, polypropylene, polytetrafluoroethylene, etc., or any combination thereof. Preferably, the outer surface of the outer tube 110 is provided with a heat-shrinkable polyether block polyamide material layer, so that blood can effectively reduce contact with the tube. In addition, thermoplastic materials have high stability, fatigue resistance, and good rebound and elastic recovery properties at low temperatures, which can improve the accuracy of the delivery tube 100 during the bending process. In some embodiments, in order to further reduce the friction between the outer tube 110 and the body, the outer surface of the outer tube 110 may also be provided with a hydrophilic coating. In some embodiments, the material of the hydrophilic coating may include polyacrylic acid, silicon dioxide, polysiloxane, siloxane, ethyl formate, etc., or any combination thereof.

[0057] The delivery tube 100 of the tissue clamping device described in the embodiment of the present application has both the delivery tissue clamping device and the bending adjustment function, which can make the corresponding medical equipment (such as valve repair equipment) more convenient during operation. It should be noted that the above description of the delivery tube 100 is for illustrative purposes only and is not intended to limit the present application. It can be understood that for those skilled in the art, after understanding the principle of the delivery tube 100 in the embodiment of the present application, various modifications and changes in form and details of the above delivery tube 100 can be made without violating this principle. For example, the outer tube 110 may not be limited to the above-mentioned first tube body 111 and the second tube body 112. In some embodiments, the outer tube 110 may also include a third tube body, a fourth tube body, etc., and the bending of the first tube body 111, the third tube body and / or the fourth tube body is controlled to adapt to surgeries on different parts of the human body.

[0058] Figure 7 is a schematic diagram of the structure of a valve repair device according to some embodiments of the present application; Figure 8 is a schematic diagram of the structure of a delivery connector and a tissue clamping device according to some embodiments of the present application; Fig. 9 is a schematic diagram of the structure of a conveying connection according to some embodiments of the present application; Fig.10 Schematic diagram of the structure of the tissue clamping device with the outer clamping arm opened according to some embodiments of the present application. Figure 7-10As shown, the valve repair device 1000 may include a tissue clamping device 200 and a control handle 300. The tissue clamping device 200 may include an outer clamping arm 220 and an inner clamping arm 210; the control handle 300 may correspondingly include an outer clamping arm control mechanism 400 and an inner clamping arm control mechanism 500. The outer clamping arm control mechanism 400 can be used to control the opening and closing of the outer clamping arm 220 of the tissue clamping device 200, and the inner clamping arm control mechanism 500 can be used to control the opening and closing of the inner clamping arm 210 relative to the outer clamping arm 220, so that the control handle 300 can control the opening and closing of the outer clamping arm 220 and the inner clamping arm 210 so that the valve (such as the mitral valve) can be clamped between the outer clamping arm 220 and the inner clamping arm 210.

[0059] In some embodiments, the valve repair device 1000 includes a delivery tube 100 of a tissue clamping device 200; the tissue clamping device 200 is connected to the control handle 300 through the delivery tube 100. In some embodiments, the control handle 300 can deliver the tissue clamping device 200 to the valve to be repaired through the delivery tube 100. For example, the control handle 300 can deliver the tissue clamping device 200 to the mitral valve through the delivery tube 100 via the femoral vein, the inferior vena cava, the right atrium, and the left atrium. In some embodiments, the control handle 300 may include a delivery tube control mechanism 600, which can be used to control the bending of the first tube body 111 of the delivery tube 100. For more details about the delivery tube 100 and the first tube body 111, refer to other embodiments of the present application (such as Figure 1-5 For more details about the delivery pipe control mechanism 600, please refer to other embodiments of the present application (such as Fig.11 Embodiment shown) and its related description.

[0060] In some embodiments, the valve repair device 1000 may also include a support tube (not shown in the figure). During the valve repair process, the support tube can be first delivered into the body. For example, during the mitral valve repair process, the support tube can be first delivered to the left atrium via the femoral vein, the inferior vena cava or the right atrium. On this basis, the control handle 300 can be used to deliver the tissue clamping device 200 to the valve to be repaired (such as the mitral valve) through the support tube. Specifically, the control handle 300 can deliver the tissue clamping device 200 through the delivery tube 100 so that the tissue clamping device 200 and the first tube body 111 extend from the front end of the support tube, and then the control handle 300 (such as the delivery tube control mechanism 600) can control the first tube body 111 to bend so that the tissue clamping device 200 is facing the valve to be repaired. If the tissue clamping device 200 cannot reach the valve to be repaired, the first tube body 111 can be controlled to extend further out of the support tube by the control handle 300, and the degree of curvature of the support tube and / or the first tube body 111 can be adjusted during the process of controlling the first tube body 111 to extend further, so that the tissue clamping device 200 moves toward the valve to be repaired. In some embodiments, the caliber of the notch 1110 of the first tube body 111 near one end of the tissue clamping device 200 can be smaller than the caliber of the notch 1110 near the other end of the first tube body 111, so that the front end of the first tube body 111 extending out of the support tube is less curved than the rear end, so as to better control the delivery of the tissue clamping device 200 to the valve to be repaired.

[0061] In some embodiments, Figure 8-10 As shown, the tissue clamping device 200 may include an inner clamp arm 210, an outer clamp arm 220, a first fixing member 230, a support portion 240, a second fixing member 250 and an outer clamp plate 260. The inner clamp arm 210 may include a first inner clamp arm 211 and a second inner clamp arm 213; the outer clamp arm 220 may include a first outer clamp arm 221 and a second outer clamp arm 223; and the outer clamp plate 260 may include a first outer clamp plate 261 and a second outer clamp plate 263. One side of the support portion 240 is bendably connected to the first outer clamp arm 221 and the first outer clamp plate 261 in sequence, and the other side of the support portion 240 is bendably connected to the second outer clamp arm 223 and the second outer clamp plate 263 in sequence. The first outer clamp arm 221 and the second outer clamp arm 223 can be bent relative to the support portion 240 and relatively closed, and the first outer clamp arm 221 and the second outer clamp arm 223 can also be bent away from the support portion 240 and relatively open. Figure 8 The tissue clamping device 200 is shown in a state where the first outer clamping arm 221 and the second outer clamping arm 223 are relatively closed; Fig.10The tissue clamping device 200 shown is in a state where the first outer clamping arm 221 and the second outer clamping arm 223 are relatively opened to 180 degrees. The angle at which the first outer clamping arm 221 and the second outer clamping arm 223 are relatively opened can be any angle, such as 10°, 40°, 90°, 120°, 180°, 270°, 350°, 360°, etc. In some embodiments, the outer clamping arm 220, the support portion 240 and the outer clamping plate 260 can be an integrally formed structure. For example, the outer clamping arm 220, the support portion 240 and the outer clamping plate 260 can be an integrally formed structure made of shape memory alloy pipes through cutting and heat treatment. In some embodiments, as Figure 8 As shown, one end of the support portion 240 (the upper end shown in the figure) is connected (such as fixedly connected) to the second fixing member 250, and one end of the first outer clamping plate 261 (the lower end shown in the figure) and one end of the second outer clamping plate 263 (the lower end shown in the figure) are respectively connected (such as fixedly connected) to the first fixing member 230. With such an arrangement, when the first fixing member 230 moves relative to the second fixing member 250, the first fixing member 230 can move relative to the support portion 240. When the first fixing member 230 is away from the support portion 240, driven by the first fixing member 230, the first outer clamping plate 261 and the second outer clamping plate 263 can respectively pull the first outer clamping arm 221 and the second outer clamping arm 223 to open relative to each other. Figure 8-10 In the embodiment shown, the outer clamp arm control mechanism 400 can control the opening and closing of the outer clamp arm 220 of the tissue clamping device 200 through the control rod 440. Specifically, one end of the control rod 440 (eg Figure 8 The lower end of the outer clamp arm 220 of the tissue clamping device 200 can have a threaded structure, through which the control rod 440 can be detachably connected to the first fixing member 230. The outer clamp arm control mechanism 400 can control the movement of the first fixing member 230 relative to the second fixing member 250 by pushing and pulling the control rod 440, thereby controlling the opening and closing of the outer clamp arm 220 of the tissue clamping device 200.

[0062] In some embodiments, the first inner clamp arm 211 can be arranged on the first outer clamp arm 221, and the second inner clamp arm 213 can be arranged on the second outer clamp arm 223. The first inner clamp arm 211 and the second inner clamp arm 213 can be opened and closed relative to the first outer clamp arm 221 and the second outer clamp arm 223, respectively, and the tissue can be clamped between the first inner clamp arm 211 and the first outer clamp arm 221 and between the second inner clamp arm 213 and the second outer clamp arm 223. In some embodiments, the inner clamp arm 210 can be a barbed clamp. For example, a barb 215 can be installed at the movable end of the inner clamp arm 210. In some embodiments, the inner clamp arm 210 and the outer clamp arm 220 can be connected by a bending portion (such as an S-bar bending structure), and the bending portion can have a prefabricated resilience, so that the inner clamp arm 210 can be close to the outer clamp arm 220 in a natural state. In some embodiments, the inner clamp arm control mechanism 500 can control the opening and closing of the inner clamp arm 210 relative to the outer clamp arm 220 through a control cable (not shown in the figure). For example, the control cable can be connected to the movable end of the inner clamp arm 210. When the inner clamp arm control mechanism 500 pulls the control cable, the inner clamp arm 210 can be opened relative to the outer clamp arm 220 under the pulling force of the control cable; when the control cable is relaxed, the inner clamp arm 210 can be closed with the outer clamp arm 220 under the prefabricated resilience of the bending portion. In some embodiments, the control cable can include steel wire, nanowire or glass rope, etc., which is not limited in the present application.

[0063] In some embodiments, the delivery tube 100 can be detachably connected to the tissue clamping device 200 via the delivery connector 140. For example, the first fixing portion 1111 of the first tube body 111 is detachably connected to the tissue clamping device 200 via the delivery connector 140 (e.g., snap-fit, threaded connection). The delivery connector 140 is provided with through holes for the control rod 440 and the control cable to pass through. Figure 8 and Fig. 9In the illustrated embodiment, the transport connector 140 may include a main body 142, a first connecting piece 144 and a second connecting piece 146. The connection between the first connecting piece 144 and the second connecting piece 146 and the main body 142 may have a prefabricated resilience, which enables the first connecting piece 144 and the second connecting piece 146 to automatically open in a natural state. A fixed support rod 148 may also be provided in the middle of the first connecting piece 144 and the second connecting piece 146, and the fixed support rod 148 is respectively perpendicular to the first connecting piece 144 and the second connecting piece 146, and a through hole for the control rod 440 to pass through is provided at one end of the fixed support rod 840 suspended. When the transport connector 140 is connected to the second fixing piece 250 of the tissue clamping device 200, the first connecting piece 144 and the second connecting piece 146 are relatively closed and are respectively engaged with the protrusions on the second fixing piece 250. At this time, the control rod 440 can pass through the through hole on the fixed support rod 148 connected to the first connecting piece 144 and the second connecting piece 146, and the control rod 440 will limit the first connecting piece 144 and the second connecting piece 146 from opening. When it is necessary to disengage the transport connector 140 from the tissue clamping device 200, the connection between the control rod 440 and the tissue clamping device 200 (such as the first fixing member 230) can be released first and the control rod 440 can be withdrawn, so that the control rod 440 is disengaged from the through hole on the fixed support rod 148 connected to the first connecting piece 144 and the second connecting piece 146, so that the first connecting piece 144 and the second connecting piece 146 automatically open and disengage from the clamping connection with the protrusion on the second fixing member 250. In some embodiments, the transport connector 140 can be an integrally formed structure made of a shape memory alloy pipe after cutting and heat treatment. In some embodiments, the tissue clamping device 200 can also be other alternative structural forms.

[0064] In some embodiments, the control handle 300 includes an outer clamp arm control mechanism 400 and an inner clamp arm control mechanism 500. The outer clamp arm control mechanism 400 is used to control the movement of the outer clamp arm 220 of the tissue clamping device 200; the inner clamp arm control mechanism 500 is used to control the movement of the inner clamp arm 210 of the tissue clamping device 200. In some embodiments, the control handle 300 may also include a delivery tube control mechanism 600, which can be used to control the bending of the first tube 111.

[0065] Fig.11 is a schematic diagram of the exploded structure of the delivery pipe control mechanism according to some embodiments of the present application. Fig.11As shown, the conveying tube control mechanism 600 may include a screw 610, a rotating part 620 and a traction part 630; the screw 610 and the traction part 630 are threadedly connected; the rotating part 620 can drive the screw 610 to rotate, thereby driving the traction part 630 to move; the movement of the traction part 630 can control the bending of the first tube 111. In some embodiments, the traction part 630 may include a traction wire 131 and a threaded traction block 635; one end (such as the tail end) of the traction wire 131 is connected to the threaded traction block 635, and the other end (such as the front end) is fixedly connected to the front end of the first tube 111, and the screw 610 is provided with an internal thread, and the threaded traction block 635 is movably arranged inside the screw 610 and matched with the internal thread of the screw 610. When the rotating part 620 drives the screw 610 to rotate, the screw 610 drives the threaded traction block 635 to move in the length direction of the screw 610, thereby achieving the traction or relaxation of the traction wire 131, and then controlling the bending of the first tube 111. Specifically, the traction of the traction wire 131 on the first tube 111 can make the multiple notches 1110 on the first tube 111 close together, so that the first tube 111 bends. When the threaded traction block 635 stops moving, the first tube 111 can remain in a bent state. When the threaded traction block 635 releases the traction wire 131, the first tube 111 can reduce the degree of bending under its own elastic force until it returns to a natural state (such as maintaining a cylindrical shape).

[0066] In some embodiments, Fig.11 As shown, the conveying tube control mechanism 600 may include a bending indication device 640. The bending indication device 640 may be used to indicate the degree of bending of the first tube body 111. In some embodiments, the bending indication device 640 may include an indication block, which may be engaged with the external thread of the screw 610 and move with the rotation of the screw 610, and the degree of bending of the first tube body 111 may be reflected by the moving position of the indication block. In some embodiments, the moving position of the indication block may correspond to the bending angle of the first tube body 111 one by one. The corresponding relationship between the two may be determined by experiments. In some embodiments, the bending indication device 640 may also include an indication mark, which may be set on a shell (such as a transparent shell covering the outside of the indication block) to intuitively reflect the degree of bending (such as the bending angle) of the first tube body 111 corresponding to the movement of the indication block to a specific position.

[0067] Fig.12 is a schematic diagram of a partial cross-sectional structure of an outer clamp arm control mechanism according to some embodiments of the present application; Fig.13 is a schematic diagram of the structure of a sleeve according to some embodiments of the present application; Fig.14 is a schematic diagram of the exploded structure of the sliding part and the protective cover according to some embodiments of the present application. Figure 12-14As shown, the outer clamp arm control mechanism 400 may include a sleeve 410, a first control portion 420 and a sliding portion 430, wherein the sliding portion 430 is disposed in the sleeve 410; the first control portion 420 can drive the sliding portion 430 to move in the sleeve 410 along the length direction of the sleeve 410 by rotating to control the opening and closing of the outer clamp arm 220. If the end of the control handle 300 close to the tissue clamping device 200 is defined as the front end, and the other end of the opposite control handle 300 is defined as the rear end, the sliding portion 430 moving toward the front end in the sleeve 410 can be used to control the opening of the outer clamp arm 220 (such as the relative opening of the first outer clamp arm 221 and the second outer clamp arm 223), and the sliding portion 430 moving toward the rear end can be used to control the closing of the outer clamp arm 220.

[0068] In some embodiments, the sleeve 410 may have one or more interlayers, the sliding part 430 is disposed in the interlayer of the sleeve 410, and the first control part 420 can drive the sliding part 430 to move in the sleeve 410 along the length direction of the sleeve 410. For example, the sleeve 410 may be in the shape of a hollow cylinder, which may be formed by connecting two semi-cylindrical shells, the sliding part 430 is in the shape of a cylinder, and the sliding part 430 can be clamped between the two semi-cylindrical shells of the sleeve 410.

[0069] In some embodiments, reference Figure 12-13 , the outer circumference of the sleeve 410 may be provided with an external thread; the inner circumference of the first control part 420 may be provided with an internal thread; the sleeve 410 and the first control part 420 are connected by threads. The sleeve 410 may be provided with a first slide groove 412 along the length direction; the sliding part 430 passes through the first slide groove 412 and is connected to the first control part 420. Specifically, the sliding part 430 may include a protruding connection block 429, and the inner circumference of the first control part 420 may include a connection groove 421, the connection block 429 can extend from the first slide groove 412 and be engaged with the connection groove 421, so that the first control part 420 can drive the sliding part 430 to move along the first slide groove 412 when rotating. In the embodiment of the present application, the sleeve 410 may include two first slide grooves 412, which are respectively arranged on both sides of the sleeve 410, and the sliding part 430 is correspondingly provided with two protruding connection blocks 429; thereby, the stability of the movement of the sliding part 430 driven by the first control part 420 can be ensured. In some alternative embodiments, the number of the first sliding grooves 412 may be one, three, five, etc.

[0070] In some embodiments, the first control part 420 may have a circular outer contour, and a rubber layer may be provided on the surface of the outer contour. When the operator controls the outer clamp arm 220 by rotating the first control part 420, the rubber layer can increase the friction between the first control part 420 and the palm or finger, so that the operator can achieve precise control. In other embodiments, the outer contour surface of the first control part 420 may not be provided with a rubber layer but may be made of a hard material such as plastic, metal, etc., and anti-slip grooves may be provided on its surface to increase surface friction.

[0071] In some embodiments, Figure 12-14 As shown, the outer clamp arm control mechanism 400 may include a control rod 440, a fixed block 460 and a protective cover 470; the sliding part 430 may control the opening and closing of the outer clamp arm 220 through the control rod 440, and the rear end of the control rod 440 is fixedly connected to the fixed block 460. Specifically, the fixed block 460 may be cylindrical, and its cross-sectional diameter may be larger than the cross-sectional diameter of the control rod 440. The control rod 440 may be inserted into the fixed block 460 and fixedly connected to the fixed block 460 by means of adhesive bonding, welding or interference connection. The protective cover 470 may be detachably connected to the sliding part 430 by threads; when the protective cover 470 is connected to the sliding part 430, the protective cover 470 may limit the relative movement of the fixed block 460 and the sliding part 430. In some embodiments, the control rod 440 can be made of a memory alloy (such as nickel-titanium alloy), so that the control rod 440 can have better tensile and compressive resistance and better bending performance; and then when the delivery tube 100 is bent, the outer clamp arm control mechanism 400 can also effectively control the opening and closing of the outer clamp arm 220 through the control rod 440.

[0072] In some embodiments, when the tissue clamping device 200 has completed clamping, the control rod 440 needs to be separated from the tissue clamping device 200 and withdrawn from the control handle 300 (eg, completely withdrawn or withdrawn a certain distance). Figure 12-14 As shown, the protective cover 470 is detachably connected to the sliding portion 430 through a thread. When the control rod 440 needs to be disengaged, the operator can rotate the protective cover 470 to disengage it from the sliding portion 430, and then the operator can rotate the fixing block 460 (i.e., rotate the control rod 440) to separate the control rod 440 from the tissue clamping device, and then the operator can pull the fixing block 460 to withdraw the control rod 440 from the control handle 300.

[0073] Fig.15 is a partial cross-sectional structural schematic diagram of an inner clamp arm control mechanism according to some embodiments of the present application; Fig.16 is a schematic diagram of a housing according to some embodiments of the present application; Fig.17 is a schematic diagram of the structure of a second control unit according to some embodiments of the present application; Fig.18is a structural schematic diagram of a second control unit and a locking mechanism at a first viewing angle according to some embodiments of the present application; Fig.19 is a schematic diagram of the structure of the second control unit and the locking mechanism at a second viewing angle according to some embodiments of the present application. Figure 15-19 As shown, the inner clamp arm control mechanism 500 may include a shell 510 and a second control part 520; a second slide groove 511 is opened on the shell 510; the second control part 520 passes through the second slide groove 511 and can move along the second slide groove 511 to control the opening and closing of the inner clamp arm 210 relative to the outer clamp arm 220.

[0074] In some embodiments, Fig.17 As shown, the second control part 520 may include an L-shaped catheter 521 and an end cap 523; one end of the catheter 521 may pass through the second slide groove 511 and be detachably connected to the end cap 523. During operation, the second control part 520 may slide in the second slide groove 511 by pushing and pulling the catheter 521 at the end cap, and the L-shaped catheter 521 is more convenient for the operator to control. In this embodiment, the second control part 520 may be connected to the inner clamp arm 210 through a control cable. In a specific embodiment, the control cable may pass through the through hole at the movable end of the inner clamp arm 210, and the two ends of the control cable may be fixed at the end cap 523. When it is necessary to separate the tissue clamping device 200 from the control handle 300, the end cap 523 may be separated from the catheter 521, and the two ends of the control cable may be released and the control cable may be pulled out, so that the control handle 300 may be separated from the inner clamp arm 210. In some embodiments, releasing the two ends of the control cable may include: releasing the clamping connection between the two ends of the control cable and the end cap, untying the knot formed by the two ends of the control cable, cutting the control cable, etc. In some embodiments, the control cable does not need to be completely pulled out of the control handle 300 , but the control cable can be separated from the inner clamp arm 210 .

[0075] In some embodiments, Fig.16 As shown, the second chute 511 can be arranged in a long strip shape. When the end cap 523 of the second control part 520 (or the part of the catheter 521 extending out of the second chute) moves to the rear end of the second chute 511 (the end away from the tissue clamping device), the inner clamp arm 210 can be in a retracted state. In some alternative embodiments, the second chute 511 can have an L-shaped profile. Specifically, a channel can be opened at the rear end of the second chute 511 in a direction at a certain angle (such as vertical) to the second chute 511. When the end cap 523 of the second control part 520 (or the part of the catheter 521 extending out of the second chute) moves to the rear end of the second chute 511, the second control part 520 can be pushed and pulled laterally so that the part of the catheter 521 extending out of the second chute is stuck in the channel, so that the inner clamp arm 210 can be kept in a retracted state to avoid misoperation during surgery.

[0076] In this embodiment, second slide grooves 511 may be respectively provided on both sides of the shell 510, and the second control unit 520 includes a first sub-control unit for controlling the first inner clamp arm 211 and a second sub-control unit for controlling the second inner clamp arm 213. The first sub-control unit and the second sub-control unit may correspond to separate control cables, respectively. In some embodiments, the second control unit 520 may be configured to be linked or split according to actual needs, so as to accurately control the inner clamp arm 210 according to the needs of experiments or surgeries. For example, during the mitral valve repair process, the first inner clamp arm 211 may be controlled to clamp one side of the mitral valve and then the second inner clamp arm 213 may be controlled to clamp the other side of the mitral valve. For another example, the second control unit 520 may simultaneously control the first inner clamp arm 211 and the second inner clamp arm 213 to clamp the mitral valve.

[0077] In some embodiments, one end of the housing 510 can be connected to (or integrally formed with) the sleeve 410, and the central axes of the housing 510 and the sleeve 410 coincide, so that the control handle 300 is more compact and easier to operate. For example, the housing 510 can be disposed at one end of the sleeve 410 close to the tissue clamping device 200, and the outer clamping arm 220 can be configured to be in the maximum open state when the first control portion 420 abuts against the rear end of the housing 510. In some alternative embodiments, the housing 510 can also be disposed at one end of the sleeve 410 away from the tissue clamping device 200.

[0078] In some embodiments, Figure 15-19 As shown, the inner clamp arm control mechanism 500 may include a locking mechanism 530; the locking mechanism 530 includes an elastic member 531, a locking button 533 and a locking stopper 535. The second control portion 520 may also include a toothed connection portion 537. The locking button 533 is used to control the locking stopper 535 to overcome the elastic force of the elastic member 531 to move so as to release the restriction of the locking stopper 535 on the toothed connection portion 537.

[0079] like Figure 15-19As shown, in this embodiment, the locking mechanism 530 includes a group of relatively arranged locking blocks 535, and the first sub-control part and the second sub-control part can respectively include corresponding toothed connecting parts 537. Specifically, the toothed connecting part 537 can be connected to the conduit 521 of the first sub-control part or the second sub-control part or formed in one piece. A group of relatively arranged locking blocks 535 can be used to limit the movement of the first sub-control part and the second sub-control part under the elastic force of the elastic member 531. For example, the locking block 535 corresponding to the first sub-control part can be clamped into the toothed connecting part 537 corresponding to the first sub-control part under the elastic force of the elastic member 531. The locking block 535 corresponding to the second sub-control part can be clamped into the toothed connecting part 537 corresponding to the second sub-control part under the elastic force of the elastic member 531. The elastic member 531 can be two springs in this embodiment. The locking button 533 can include two, respectively connected to the two locking blocks 535. The locking button 533 can be exposed from the housing 510. Taking the operation of the first sub-control part as an example, when the locking button 533 corresponding to the first sub-control part is pressed, the locking button 533 drives the locking block 535 to overcome the elastic force of the elastic member 531 and thus disengage from the toothed connection part 537, and the operator can push and pull the first sub-control part (such as the conduit 521 of the first sub-control part) to slide in the second slide groove 511 to control the opening and closing of the first inner clamp arm 211. When the operator releases the locking button 533, driven by the elastic force of the elastic member 531, the locking block 535 can be re-engaged in the toothed connection part 537 to restrict the movement of the toothed connection part 537 (i.e., the movement of the conduit 521). The operation of the second sub-control part is similar to that of the first sub-control part, and will not be described in detail here.

[0080] In some embodiments, since there are two lock buttons 533, in order to facilitate identification by the operator, a mark can be added to the lock button 533. The mark can be "left", "right", "L", "R" or an arrow, etc.

[0081] The beneficial effects that may be brought about by the embodiments of this specification include but are not limited to: (1) The delivery tube has both a delivery tissue clamping device and a bending adjustment function, which can make the corresponding medical equipment (such as valve repair equipment) more convenient to operate; (2) The delivery tube can be quickly and accurately bent; (3) The space required for the delivery tube during the bending process can be effectively reduced through the cooperation of the traction mechanism and the first tube body, so that it is suitable for various surgeries; (4) The outer clamping arm and / or the inner clamping arm of the tissue clamping device can be quickly and accurately controlled; (5) The operation of valve repair can be more convenient, and the efficiency and success rate of repair can be higher. It should be noted that different embodiments may produce different beneficial effects. In different embodiments, the beneficial effects that may be produced may be any one or a combination of the above, or any other possible beneficial effects.

[0082] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A delivery tube for a tissue clamping device, characterized in that: It includes an outer tube, an inner core and a traction mechanism; The outer tube is sleeved outside the inner core; the inner core is made of elastic material; The outer tube comprises a first tube body and a second tube body, one end of the first tube body is connected to the tissue clamping device, and the other end of the first tube body is connected to the second tube body; The second tube body is a mesh woven structure; a plurality of notches are opened on one side of the first tube body along its length direction, and the first tube body can be bent toward the opening direction of the plurality of notches; The traction mechanism is used to control the bending of the first tube body; the traction mechanism includes a traction wire and a spring tube, one end of the traction wire is fixedly connected to one end of the first tube body; one side of the inner core is provided with a groove along its length direction, and the traction wire is arranged in the groove; the spring tube is sleeved on the part of the traction wire corresponding to the second tube body.

2. The delivery tube of the tissue clamping device according to claim 1, characterized in that: The diameters of the plurality of notches are the same or different.

3. The delivery tube of the tissue clamping device according to claim 2, characterized in that: The diameter of the notch near the one end of the first tube body is smaller than the diameter of the notch near the other end of the first tube body.

4. The delivery tube of the tissue clamping device according to claim 1, characterized in that: The first tube body is cut and formed in one piece from a shape memory alloy tube.

5. The delivery tube of the tissue clamping device according to claim 1, characterized in that: The traction mechanism also includes a blocking member, which is sleeved on the traction wire and fixed at the connection between the first tube body and the second tube body to form a blocking member for the spring tube.

6. The delivery tube of the tissue clamping device according to claim 5, characterized in that: A connecting piece is provided at the connection between the first tube body and the second tube body, and the blocking piece is fixedly connected to the connecting piece.

7. The delivery tube of the tissue clamping device according to claim 1, characterized in that: The one end of the first tube is connected to the tissue clamping device through a delivery connection piece.

8. The delivery tube of the tissue clamping device according to claim 1, characterized in that: The inner core is provided with a through hole for the control rod and / or control cable of the tissue clamping device to pass through.

9. The delivery tube of the tissue clamping device according to claim 1, characterized in that: The outer surface of the outer tube is also provided with a heat shrinkable polyether block polyamide material layer.

10. A valve repair device, characterized in that: The valve repair device comprises a delivery tube of the tissue clamping device according to any one of claims 1 to 9.

11. The valve repair device according to claim 10, characterized in that: The valve repair device comprises a control handle, and the control handle comprises a delivery tube control mechanism, and the delivery tube control mechanism is used to control the bending of the first tube body of the delivery tube.

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