Electronic quality control card

Abstract

The present application provides an electronic quality control card, which relates to the field of immunochromatographic detection, including: an optical module, including a first light source unit and a second light source unit; a containing member, which is used to limit the optical module; the containing member is formed with a non-slit detection window, and the light emitted by the first light source unit and the light emitted by the second light source unit are both emitted to the external environment through the detection window. The electronic quality control card provided by the present application adopts a non-slit design, which eliminates the interference of the slit on the obtained light signal, so that the detection signal can more realistically simulate the peak diagram of the fluorescent test strip, and to a certain extent solves the problem that the fluorescent substance of the reagent card marked with fluorescent molecules (or fluorescent quantum dots) in the prior art is easily quenched, the signal value will decrease, and the test strip is greatly affected by temperature and humidity, the signal value is unstable, and the existing electronic quality control card has technical problems of peak distortion.

Description

Technical Field

[0001] The present application relates to the field of immunochromatographic detection, and in particular to an electronic quality control card. Background Art

[0002] The existing technology usually uses reagent cards labeled with fluorescent molecules (or fluorescent quantum dots) as calibration cards. Since the fluorescence of fluorescent molecules or quantum dots is greatly affected by the surrounding environment, the stability is difficult to guarantee, that is, the fluorescent substance is easily quenched, the signal value will decrease, and the test strip is greatly affected by temperature and humidity, and the signal value is unstable, which makes it difficult to formulate standards and perform long-term calibration traceability.

[0003] Although electronic quality control cards have appeared in the prior art, there is a problem of unstable quality caused by peak distortion. Summary of the invention

[0004] In view of this, the present application provides an electronic quality control card, the purpose of which is to solve the above technical problems to a certain extent.

[0005] The present application provides an electronic quality control card, the electronic quality control card comprising:

[0006] The optical module comprises a first light source part and a second light source part;

[0007] A containing member, used to define the optical module;

[0008] The receiving member is formed with a non-slit detection window, and the light emitted by the first light source part and the light emitted by the second light source part are both emitted to the external environment through the detection window.

[0009] Preferably, the detection window is formed as follows:

[0010] The distance between two points of the detection window farthest from each other in the projection of the light emitted by the first light source unit or the second light source unit in the irradiation direction is greater than the wavelength of the light emitted by the first light source and greater than the wavelength of the light emitted by the second light source.

[0011] Preferably, the optical module comprises a resistor part, and the resistance value of the resistor part in the circuit of the light source module is designed so that the light emitted by the first light source part and the light emitted by the second light source part are emitted into the instrument to be detected in a non-interference manner.

[0012] Preferably, the optical module further comprises:

[0013] A power supply, used to supply power to the first light source unit and the second light source unit;

[0014] The first group of branches and the second group of branches are connected in parallel to the power supply, the first light source unit and the first resistor unit of the resistor unit are located in the first group of branches, and the second light source unit and the second resistor unit of the resistor unit are located in the second group of branches.

[0015] Preferably, the first group of branches includes one first branch or multiple first branch connected in parallel, the first branch includes a first resistor component of the first resistor section, the first light source section includes a first light emitting component, and the first light emitting component is connected in series with the first resistor component; the second group of branches includes one second branch or multiple second branch connected in parallel, the second branch includes a second resistor component of the second resistor section, the second light source section includes a second light emitting component, and the second light emitting component is connected in series with the second resistor component;

[0016] The first resistance member has a range of 22 kΩ to 220 kΩ, and the second resistance member has a range of 22 kΩ to 220 kΩ.

[0017] Preferably, the electronic quality control card further comprises: a printed circuit board, and the power supply, the first light source unit, the first resistance component, the second light source unit and the second resistance component are all detachably integrated on the printed circuit board.

[0018] Preferably, the electronic quality control card further comprises a switch component for controlling the on and off of the power supply, wherein at least a portion of the switch component is exposed to an outer side of the accommodating component, and the accommodating component is formed as a shell component covering the light source module.

[0019] Preferably, the shell member includes a first shell and a second shell engaged with each other, the first shell is formed with the detection window and the switch gap, at least part of the switch member is exposed to the switch gap, and the first light source and the second light source can be observed through the detection window.

[0020] Preferably, the wavelength of the light emitted by the first light source is equal to the wavelength of the light emitted by the second light source.

[0021] Preferably, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source are both 500nm-1000nm.

[0022] Preferably, the detection window is formed in a long hole shape.

[0023] The electronic quality control card provided in the present application adopts a non-slit design, which eliminates the interference of the slit on the obtained light signal, so that the detection signal can more realistically simulate the peak shape of the fluorescent test strip. To a certain extent, it solves the technical problems that the fluorescent substances of the reagent cards marked with fluorescent molecules (or fluorescent quantum dots) in the prior art are easily quenched, the signal value will decrease, and the test strips are greatly affected by temperature and humidity, the signal value is unstable, and the existing electronic quality control cards have peak distortion.

[0024] In order to make the above-mentioned objects, features and advantages of the present application more obvious and easy to understand, preferred embodiments are specifically cited below and described in detail with reference to the attached drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0026] Figure 1 A schematic diagram showing a circuit diagram of an electronic quality control card provided by the present application;

[0027] Figure 2 A schematic diagram showing a comparison diagram of a signal peak obtained by testing an electronic quality control card provided with a slit and a signal peak obtained by testing the electronic quality control card of the present application;

[0028] Figures 3a to 3e A schematic diagram showing a process of obtaining the resistance range of the first resistor and the resistance range of the second resistor of the electronic quality control card of the present application;

[0029] Figure 4 A schematic diagram of an electronic quality control card with a slit in the prior art is shown;

[0030] Figure 5 A schematic diagram of the electronic quality control card provided in the present application is shown.

[0031] Reference numerals:

[0032] 1- containing member; 10- slit; 20- detection window. DETAILED DESCRIPTION

[0033] The technical solution of the present application will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0034] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0035] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0036] In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the fact that they can be implemented by ordinary technicians in this field. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0037] The electronic quality control card provided in this embodiment includes an optical module and a containing component, and the structure and working principle of these components will be described in detail below.

[0038] In the embodiment, the optical module includes a first light source unit and a second light source unit, and the first light source unit and the second light source unit are capable of emitting light, and the specific emitting process thereof will be described in the subsequent description. The above-mentioned containing member 1 (corresponding to the shell body of the electronic quality control card) can be formed with a single detection window 20, and is used to define the optical module. The definition here can be understood as that when the optical module is defined by the containing member 1, the light emitted by the first light source unit and the light emitted by the second light source unit are both emitted to the external environment through the detection window 20.

[0039] As a preferred arrangement, the optical module can be accommodated in the accommodating member 1, that is, the accommodating member 1 forms a cavity for providing a space for accommodating the optical module, and the above "external environment" can be understood as being separated from the cavity via the accommodating member 1 and connected via the detection window 20. Further, the accommodating member 1 can include a first shell (corresponding to the upper cover of the shell body of the electronic quality control card) and a second shell (corresponding to the lower cover of the shell body of the electronic quality control card), and the two can define the aforementioned cavity via a detachable connection method such as a snap connection or a screw connection.

[0040] Reference Figure 4 and Figure 5 , first see Figure 5 The detection window 20 may be, for example, provided in the first housing of the containing member 1, and the detection window 20 may be formed as a non-slit. The "slit 10" mentioned here may, for example, refer to a single slit gap in a substantially long strip shape (e.g., a rectangular shape) with a width of 0.2 to 5 mm on the first housing. Therefore, it can be understood that in this embodiment, the detection window 20 is not formed as such a single slit (i.e., Figure 4 ), as a result, when the light emitted by the first light source unit and the second light source unit is emitted into the external environment through the detection window 20, no obvious diffraction phenomenon occurs. Based on such a concept, the aforementioned detection window 20 can be constructed as follows: the distance between the two points farthest from each other in the projection of the detection window 20 on a plane perpendicular to the irradiation direction of the light emitted by the first light source unit is greater than the wavelength of the light emitted by the first light source, and the distance between the two points farthest from each other in the projection of the detection window 20 on a plane perpendicular to the irradiation direction of the light emitted by the second light source unit is greater than the wavelength of the light emitted by the second light source.

[0041] The "irradiation direction" mentioned in the above description is jointly determined by the first light source unit (the second light source unit) and the detection window 20, that is, the propagation direction of the part of the light emitted by the first light source unit (the second light source unit) that can be emitted to the external environment through the detection window 20. Therefore, the projection of the detection window 20 on a plane perpendicular to the propagation direction forms a transmission area of ​​the detection window 20 for a certain light source unit. It can be understood that in order to maximize the transmission area to maximize the utilization of the detection window 20 that is essentially formed as a hole portion (i.e., a notch portion), the detection window 20 can be further constructed so that the first light source and the second light source can be directly observed through the detection window 20. As an advantageous setting, the detection window 20 can be formed in the shape of a long hole, which is a so-called waist-shaped hole or a strip-shaped hole. Its advantages will be explained later in conjunction with the principle of the optical module.

[0042] Based on the above-described features, the structure and working principle of the optical module will be described in detail below. Figure 1As shown, Figure 1 1 shows a circuit diagram of an optical module, which circuit can be integrated on a PCB (printed circuit board), which will also be explained in the subsequent description. Figure 1 As shown in , the optical module may include a resistor portion, and the resistor portion may be designed to allow the light emitted by the first light source portion and the light emitted by the second light source portion to be emitted into the instrument to be detected in a manner that does not interfere with each other.

[0043] It should be noted that "no interference" means that the waveform output by the instrument to be tested does not interfere with the output waveform. Figure 2 The solid line image shown in is an example of a situation where no interference occurs. As a comparison, Figure 2 The dotted line image shown in the figure is a case where the peak shapes generated by detecting two light source parts are interfered. During the comparison process, it can be found that when the peak shapes are interfered, the peak shapes are obviously distorted.

[0044] Continue to see Figure 1 The optical module may further include a power supply and first to fourth branch paths. The power supply may be used to supply power to the first light source unit and the second light source unit. Figure 1 In the embodiment, the upper part of the power supply is the positive pole, the lower part is the negative pole, and the first branch to the fourth branch can all be connected in parallel to the power supply. Figure 1 In the figure, the four branch roads are arranged in sequence from left to right (i.e., the leftmost branch road is formed as the first branch road), the first branch road may include a first resistor component and a first light-emitting diode connected in series, the second branch road may include a first resistor component and a second light-emitting diode connected in series, the third branch road may include a second resistor component and a third light-emitting diode connected in series, and the fourth branch road may include a second resistor component and a fourth light-emitting diode connected in series.

[0045] In the embodiment, the anodes of the first to fourth light emitting diodes are all Figure 1 , so when Figure 1 When the switch located in the main circuit is closed to turn on the circuit, all four LEDs can emit light. Among the above four LEDs, the first LED and the second LED can be jointly formed as the first light source unit, and the third LED and the fourth LED can be jointly formed as the second light source unit. Therefore, the above-mentioned long hole-shaped detection window 20 can ensure a sufficient span, so that even when so many or even more LEDs are provided, the two light source units can still be directly observed through the detection window 20. On this basis, the area corresponding to the first light source unit can be defined as a test strip, and the area corresponding to the second light source unit can be defined as a test strip. It is also understandable that the resistor unit may include the following: Figure 1 Two first resistance components and two second resistance components are arranged in.

[0046] In an embodiment, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source may be equal, and may be 500nm-1000nm. Therefore, the above four light emitting diodes may be formed as the same light emitting diode. In addition, the above switch may be installed via a switch notch formed in, for example, the first housing so that at least part of the switch is exposed to the outer side of the containing member 1, thereby enabling the operator to control the opening and closing of the above circuit via at least part of the switch exposed to the outer side of the containing member 1. In addition, as an advantageous option, the above light emitting diodes, resistors, power supplies and switches may be mounted on the PCB in a detachable manner for easy replacement and maintenance.

[0047] Based on the above-described features, the value range of the first resistance component can be 22kΩ to 220kΩ, and the value range of the second resistance component can be 22kΩ to 220kΩ. Therefore, the first resistance component and the second resistance component can be played by the same unit resistor. Figures 3a to 3e As well as specific data, the above value range is explained. In the following table, T represents the peak area of ​​the test strip, C represents the peak area of ​​the quality control strip, and T / C is the ratio of the peak area of ​​the test strip to the peak area of ​​the quality control strip.

[0048] Table 1:

[0049]

[0050] Table 1 and Figure 3a Scheme A used in the process of obtaining the above unit resistance value range is given. In Scheme A, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source can both be set to 850nm, and the unit resistance can both be formed as a resistance with a resistance value of 220Ω. See Table 1 and Figure 3a ,The verification results show that the resistance value is too small and the optical signal is too large, ,which causes the peak on the right to rush to the top and the two peaks to interfere with each other.

[0051] Table 2:

[0052]

[0053] Table 2 and Figure 3b Scheme B used in obtaining the above unit resistance value range is given. In Scheme B, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source can both be set to 850nm, and the unit resistance can both be formed as a resistance with a resistance value of 2.2kΩ. Figure 3b ,The verification results still show that due to the small resistance value and the large optical signal, the peak on the left and the peak on the right both have different degrees of peaking and the two peaks interfere with each other.

[0054] Table 3:

[0055]

[0056] Table 3 and Figure 3c Scheme C used in the process of obtaining the above unit resistance value range is given. In Scheme C, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source can both be set to 850nm, and the unit resistance can both be formed as a resistance with a resistance value of 22kΩ. See Table 3 and Figure 3c ,The verification results show that the resistance value is appropriate, the left peak type and the right peak type do not interfere with each other, and the calculated coefficient of variation is less than 2%.

[0057] Table 4:

[0058]

[0059] Table 4 and Figure 3d Scheme D used in the process of obtaining the above unit resistance value range is given. In Scheme D, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source can both be set to 850nm, and the unit resistance can both be formed as a resistance with a resistance value of 220kΩ. See Table 4 and Figure 3d ,The verification results show that the resistance value is appropriate, the left peak type and the right peak type do not interfere with each other, and the calculated coefficient of variation is less than 3%.

[0060] Figure 3e Scheme E used in the process of obtaining the above unit resistance value range is given. In Scheme E, the wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source can both be set to 850nm, and the unit resistor can both be formed as a resistor with a resistance value of 20Ω. See Table 4 and Figure 3d ,The verification results show that the resistance value is too small, the peak shape is distorted and interferes with each other, and the peak area cannot be calculated.

[0061] After the above verification, it is finally determined that the value range of the first resistor can be 22 kΩ to 220 kΩ, and the value range of the second resistor can be 22 kΩ to 220 kΩ.

[0062] The electronic quality control card provided in this embodiment adopts a non-slit design, which eliminates the interference of the slit on the obtained light signal, so that the detection signal can more realistically simulate the peak diagram of the fluorescent test strip, and the electronic quality control card in this embodiment further eliminates the interference of the finally obtained light signal with the above resistance value range, and can also install resistors of different resistance values ​​according to the required peak area. In addition, since the electronic quality control card has its own power supply, it is convenient to use and does not require power supply from the instrument.

[0063] This embodiment also provides a fluorescence instant test instrument, which uses the above electronic quality control card to test the detection function of the fluorescence instant test instrument, and has all the above beneficial effects, which will not be repeated here.

[0064] The above are only preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. All equivalent structural changes made by using the contents of the present application specification and drawings under the innovative concept of the present application, or directly / indirectly applied in other related technical fields are included in the protection scope of the present application.

Claims

1. An electronic quality control card, comprising: The optical module comprises a first light source part and a second light source part; The containing member is used to define the optical module; characterized in that: The receiving member is formed with a non-slit detection window, and the light emitted by the first light source unit and the light emitted by the second light source unit are both emitted to the external environment through the detection window; The optical module comprises a resistor part, the resistance value of which in the circuit of the optical module is designed so that the light emitted by the first light source part and the light emitted by the second light source part are emitted into the instrument to be detected in a manner that does not interfere with each other; The optical module further comprises: A power supply, used to supply power to the first light source unit and the second light source unit; A first group of branches and a second group of branches are connected in parallel to the power supply, the first light source unit and the first resistor unit of the resistor unit are located in the first group of branches, and the second light source unit and the second resistor unit of the resistor unit are located in the second group of branches; The detection window is formed in a long hole shape.

2. The electronic quality control card according to claim 1, characterized in that: The detection window is formed as follows: The distance between two points of the detection window farthest from each other in the projection of the light emitted by the first light source unit or the second light source unit in the irradiation direction is greater than the wavelength of the light emitted by the first light source and greater than the wavelength of the light emitted by the second light source.

3. The electronic quality control card according to claim 1, characterized in that: The first group of branches includes one first branch or multiple first branch connected in parallel, the first branch includes a first resistor component of the first resistor section, the first light source section includes a first light emitting component, and the first light emitting component is connected in series with the first resistor component; the second group of branches includes one second branch or multiple second branch connected in parallel, the second branch includes a second resistor component of the second resistor section, the second light source section includes a second light emitting component, and the second light emitting component is connected in series with the second resistor component; The first resistance member has a range of 22 kΩ to 220 kΩ, and the second resistance member has a range of 22 kΩ to 220 kΩ.

4. The electronic quality control card according to claim 3, characterized in that: The electronic quality control card further includes: a printed circuit board, and the power supply, the first light source unit, the first resistance component, the second light source unit and the second resistance component are all detachably integrated on the printed circuit board.

5. The electronic quality control card according to claim 4, characterized in that: The electronic quality control card further includes a switch component for controlling the on and off of the power supply, at least a portion of the switch component is exposed to the outer side of the accommodating component, and the accommodating component is formed as a shell component covering the optical module.

6. The electronic quality control card according to claim 5, characterized in that: The shell member includes a first shell and a second shell engaged with each other, the first shell is formed with the detection window and a switch gap, at least a portion of the switch member is exposed to the switch gap, and the first light source and the second light source can be observed through the detection window.

7. The electronic quality control card according to claim 1 or 2, characterized in that: The wavelength of the light emitted by the first light source is equal to the wavelength of the light emitted by the second light source.

8. The electronic quality control card according to claim 7, characterized in that: The wavelength of the light emitted by the first light source and the wavelength of the light emitted by the second light source are both 500nm-1000nm.

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