A detachable detection device

Abstract

The present invention discloses a detachable detection device, which includes a first chamber located inside the cup body for collecting samples; a second chamber located inside the sample bottle; a first channel for communicating the first chamber and the second chamber; and a movable sealing element, and the communication state and non-communication state between the first chamber and the second chamber are achieved by the movement of the sealing element. On the basis of the basic functions of collecting and detecting samples, the detection device also has the function of collecting samples into the sample bottle for secondary detection. The sample bottle can be separately disassembled from the inside of the detection device. Therefore, the samples in the sample bottle will definitely not be affected by the test elements in the detection device, ensuring the purity of the retained samples.

Description

Technical Field

[0001] The present invention relates to a detection device, and more particularly to a device that can perform detection and collection. Background Art

[0002] The following introduction of the background art is only an introduction to some common sense of the background and will not constitute any limitation to the present invention.

[0003] Currently, detection devices for detecting whether an analyte is contained in a sample are widely used in hospitals or at home. These detection devices for rapid diagnosis include one or more test strips, such as early pregnancy detection, drug abuse detection, and so on. Such rapid diagnosis detection devices are very convenient and can obtain test results on the test strip in one minute, or at most about ten minutes.

[0004] Drug detection is widely used in institutions such as anti-drug departments, public security bureaus, drug rehabilitation centers, physical examination centers, and national military recruitment physical examination sites. There are various types of drug detections and frequent tests. There is a huge market demand for drug detection urine cups that can automatically separate the remaining sample from the detected sample. After the detection is completed in the current market drug detection urine cups, the sample in the urine cup will be contaminated by the test reagent and cannot be used for the second confirmation test, as described in, for example, US Patent 7300633.

[0005] There are a large number of disposable detection devices that integrate collection and detection in the prior art. For example, as described in Chinese Patent 2008103055231, it includes a cup body, and a test board with a test paper is provided on the side of the cup body. The area where the cup body and the test board are located can be communicated. As described in paragraph 0005 of the specification of this document, the person to be tested places urine in the urine cup. At this time, the positioning component controls the liquid outlet on the test board not to communicate with the communication hole on the cup body. When the person to be tested needs to perform a test, the person adjusts the positioning component to communicate the liquid outlet with the communication hole, and at the same time inverts the cup body, and the urine flows into the test strip cavity to autonomously start the reaction. When the reaction ends, the result is interpreted and recorded, and the urine cup is placed upright, realizing the separation of the urine in the detection area from the urine in the urine cup. Although this detection device can achieve the separation of the urine in the detection area from the urine in the urine cup, this form of separation is not thorough. The separation of the urine in the detection area from the urine in the urine cup is essentially still within the same detection device, which is very inconvenient. For example: when an operator needs to retain the urine in the urine cup for subsequent secondary testing, he either saves it together with the detection area (whether the test agent in the detection area will generate and / or volatilize substances that affect the urine in the urine cup is unknown to us); or extracts a part of the urine in the urine cup and stores it in another collection container (although this method can ensure that the sample is not contaminated, the operation is relatively cumbersome).

[0006] In view of the above technical problems, it is necessary to improve them and provide an alternative approach to address the deficiencies of the existing traditional technologies. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a detachable detection device for solving the above technical problems.

[0008] The technical solution adopted by the present invention to solve the above technical problems is as follows: A detachable detection device includes a first chamber located inside the cup body for collecting samples; a second chamber located inside the sample bottle; a first channel for connecting the first chamber and the second chamber; and a movable sealing element, and the connection state and non-connection state between the first chamber and the second chamber are achieved by the movement of the sealing element.

[0009] Furthermore, the sealing element includes two working positions: a first working position and a second working position. When the sealing element is in the first working position, the sealing element is inserted into the first channel, and the first chamber and the second chamber are in a non-connected state; when the sealing element is in the second working position, the sealing element is separated from the first channel, and the first chamber and the second chamber are in a connected state.

[0010] Furthermore, the detection device includes two working states: upright and inverted.

[0011] Furthermore, when the detection device is in the upright state, the second chamber is located above the first chamber; when the detection device is in the inverted state, the first chamber is located above the second chamber.

[0012] Furthermore, the sample bottle is detachable, and when the sample bottle is removed, the first chamber and the second chamber are separated.

[0013] Furthermore, the sealing element is detachable.

[0014] Furthermore, it further includes a first cover body, the first cover body is detachably connected to the cup body, and the space formed by assembling the first cover body and the cup body is the second chamber.

[0015] Furthermore, the first channel is provided on the first cover body.

[0016] Furthermore, the first cover body is detachably connected to a sample bottle, the sample bottle includes a bottle mouth, and the first channel extends into the bottle mouth.

[0017] Furthermore, it further includes a second cover body, the sealing element is connected to the second cover body, and the second cover body is detachably connected to the cup body.

[0018] Furthermore, the sealing element is conical, and a sealing ring is installed on the sealing element.

[0019] Furthermore, the inside of the sealing element is hollow, and holes are provided on the surface of the sealing element.

[0020] Furthermore, a second channel is provided in the first cavity, and a rod body is provided on the second cover body. The rod body passes through the second channel and is connected to the sealing element.

[0021] Furthermore, it further includes a third cover body. The third cover body is detachably connected to the first cover body, and the third cover body is detachably connected to the sample bottle. The space formed by assembling the third cover body and the first cover body wraps the sample bottle inside.

[0022] The beneficial effects of the present invention are as follows: On the basis of the basic functions of collecting and detecting samples, the detection device of the present invention also has the function of collecting samples into the sample bottle for secondary detection. The sample bottle can be individually disassembled from the inside of the detection device. Therefore, the sample in the sample bottle will definitely not be affected by the test elements in the detection device, ensuring the purity of the retained sample; by quantifying the volume of the sample bottle, the volume of the collected sample can be accurately controlled, facilitating subsequent secondary quantitative detection, and the obtained detection results are true, reliable, and have high accuracy; in addition, the detection device of the present invention is exquisitely designed, and the use method is simple and easy to operate. Description of the Drawings

[0023] Figure 1 is an overall structural schematic diagram of a detachable detection device;

[0024] Figure 2 is Figure 1 a cross-sectional view of

[0025] Figure 3 is Figure 1 an exploded view of

[0026] Figure 4 is a connection schematic diagram between the third cover body, the sample bottle, the first cover body, and the cup body;

[0027] Figure 5 is a schematic diagram when adding a sample into the cup body;

[0028] Figure 6 is a schematic diagram when the detection device is inverted;

[0029] Figure 7 is Figure 6 a cross-sectional view of

[0030] Figure 8 is Figure 6 a schematic diagram of the detection device after opening the second cover body;

[0031] Figure 9 is Figure 8 a cross-sectional view of

[0032] Figure 10 is Figure 6Schematic diagram after the detection device opens the third cover;

[0033] Figure 11 is Figure 10 Schematic diagram in another direction;

[0034] Figure 12 is the overall structural schematic diagram after the sample bottle is removed from the detection device. Detailed description

[0035] The following further describes the structures involved in the present invention or the technical terms used herein. If not specifically specified, they are understood and interpreted according to the general terms commonly used in the art.

[0036] Detection

[0037] Detection means assaying or testing for the presence of a substance or material, such as, but not limited to, chemical substances, organic compounds, inorganic compounds, metabolites, drugs or drug metabolites, organic tissues or metabolites of organic tissues, nucleic acids, proteins or polymers. Additionally, detection means testing the quantity of a substance or material. Further, assay also means immunoassay, chemical assay, enzyme assay, etc.

[0038] Sample

[0039] The detection device of the present invention or the collected samples include biological liquids (such as case liquids or clinical samples). Liquid samples or liquid specimens, or fluid samples or fluid specimens, can be derived from solid or semi-solid samples, including excreta, biological tissues and food samples. Any suitable method can be used to convert solid or semi-solid samples into liquid samples, such as mixing, mashing, macerating, incubating, dissolving or digesting solid samples by enzymatic action in a suitable solution (such as water, phosphate solution or other buffer solutions). "Biological samples" include samples derived from animals, plants and food samples, such as urine, saliva, blood and its components, cerebrospinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures and media derived from humans or animals. Preferably, the biological sample is urine, and preferably, the biological sample is saliva. Food samples include food processing substances, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell cultures and media. "Environmental samples" are derived from the environment (for example, liquid samples from lakes or other water bodies, sewage samples, soil samples, groundwater, seawater and waste liquid samples). Environmental samples can also include sewage or other wastewater.

[0040] Test element

[0041] As used herein, the so-called "test element" refers to any element that can detect whether a sample or specimen contains an analyte of interest, and such a detection can be based on any technical principle, such as immunology, chemistry, electrochemistry, optics, molecular biology, nucleic acids, physics, etc. The test element can be a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention.

[0042] Various test elements can be combined and used in the present invention. One form is the test strip. The test strip for analyzing analytes (such as drugs or metabolites indicating physical conditions) in a sample can be in various forms, such as in the form of immunoassay or chemical analysis. The test strip can adopt a non-competitive or competitive analysis mode. The test strip generally includes a water-absorbing material having a sample application area, a reagent area, and a test area. The sample is added to the sample application area and flows to the reagent area by capillary action. In the reagent area, if the analyte is present, the sample binds to the reagent. Then the sample continues to flow to the detection area. Some other reagents, such as molecules specifically binding to the analyte, are immobilized in the detection area. These reagents react with the analyte (if present) in the sample and bind the analyte in this area, or bind to one of the reagents in the reagent area. The label for displaying the detection signal is present in the reagent area or a separate label area.

[0043] In a typical non-competitive analysis mode, if the sample contains the analyte, a signal will be generated, and if it does not contain the analyte, no signal will be generated. In the competitive method, if the analyte is not present in the sample, a signal is generated, and if the analyte is present, no signal is generated.

[0044] The test element can be a test strip, and materials that absorb water or do not absorb water can be selected. The test strip can include a variety of materials for liquid sample transfer. One material of the test strip can cover another material, such as filter paper covering a nitrocellulose membrane. One or more materials can be selected for one area of the test strip, while one or more other different materials can be selected for another area. The test strip can be adhered to a certain support or a rigid surface to improve the strength of holding the test strip.

[0045] The analyte is detected through a signal generation system. For example, one or more enzymes that specifically react with the analyte are used. By the method of immobilizing specific binding substances on the test strip as described above, a composition of one or more signal generation systems is immobilized in the analyte detection area of the test strip. The substance generating the signal can be in the sample application area, the reagent area, or the detection area, or throughout the test strip, and this substance can fill one or more materials of the test strip. A solution containing the signal substance is added to the surface of the test strip or one or more materials of the test strip are immersed in a solution containing the signal substance. The test strip added with the solution containing the signal substance is dried.

[0046] The various zones of the test strip can be arranged in the following manner: a sample application zone, a reagent zone, a detection zone, a control zone, a zone for determining whether the sample is adulterated, and a liquid sample absorption zone. The control zone is located after the detection zone. All the zones can be arranged on a single test strip made of only one material. Or different zones can use different materials. Each zone can be in direct contact with the liquid sample, or the different zones can be arranged according to the flow direction of the liquid sample, with the ends of each zone connected and overlapped with the front end of another zone. The materials used can be materials with good water absorption such as filter paper, glass fiber, or nitrocellulose membrane, etc. The test strip can also be in other forms.

[0047] The commonly used reagent strip is usually a nitrocellulose membrane reagent strip, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection result; it can also be an acetate cellulose membrane or a nylon membrane, etc. For example, some reagent strips or devices containing reagent strips described in the following patents: US4857453; US 5073484; US5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US6352862; US 6372515; US 6379620; and US 6403383. The test strips and similar devices with test strips disclosed in the above patent documents can all be applied to the test element or detection device of the present invention for detecting the analyte, such as detecting the analyte in the sample.

[0048] The detection reagent strip applied to the present invention can be the commonly referred to lateral flow test strip. The specific structures and detection principles of these detection reagent strips are well-known to those of ordinary skill in the art in the prior art. Ordinary detection reagent strips include a sample collection area or a sample addition area, a labeling area, a detection area, and a water absorption area. The sample collection area includes a sample receiving pad, the labeling area includes a labeling pad, and the water absorption area can include a water absorption pad. Among them, the detection area includes the necessary chemical substances for detecting whether the analyte is contained, such as immunoassay reagents or enzyme chemical reagents. Commonly used detection reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Of course, a detection result control area can also be included downstream of the detection area. Usually, the control area and the detection area appear in the form of horizontal lines, which are detection lines or control lines. Such detection reagent strips are traditional reagent strips. Of course, it can also be other types of reagent strips that use capillary action for detection. In addition, generally, the detection reagent strip has dry chemical reagent components, such as fixed antibodies or other reagents. When encountering a liquid, the liquid flows along the reagent strip by capillary action. As it flows, the dry reagent components dissolve in the liquid, so as to react with the dry reagents in the next area, thereby performing the necessary detection. The liquid flow is mainly carried out by capillary action. All of these can be applied to the detection device of the present invention, or be arranged in the first chamber to contact the liquid sample, or be used to detect whether the analyte exists or the quantity of the analyte existing in the liquid sample entering the first chamber.

[0049] Analyte

[0050] Examples of analytes involved in the present invention include some small molecule substances, and these small molecules include drugs (such as abused drugs). "Drug of abuse" (DOA) refers to the non-medical use of drugs (usually acting as nerve paralytics). The abuse of these drugs can cause physical and mental damage, dependence, addiction and / or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black beauties, white amphetamine tablets, dextroamphetamine, dextroamphetamine tablets, Beans); methamphetamine MET (crank, metamphetamine, crystal, speed); barbiturate BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep aids); lysergic acid diethylamide (LSD); depressants (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); tricyclic antidepressants (TCA, i.e., imipramine, amitriptyline, and doxepin); 3,4-methylenedioxymethamphetamine (MDMA); phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine MOP or opium, cocaine COC, heroin, hydrocodone); anxiolytics and sedative-hypnotics. Anxiolytics are a class of drugs mainly used to relieve anxiety, tension, fear, stabilize emotions, and have hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ classes, fused diazepines NB23C classes, benzazepines, ligands of BZ receptors, open-ring BZ classes, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazine and thiazole derivatives, other heterocyclic classes, imidazole-type sedative / painkillers (such as hydrocodone OXY, methadone MTD); propylene glycol derivatives - carbamates, aliphatic compounds, anthracene derivatives, etc. The test kit of the present invention can also be used for the detection of drugs that are for medical use but are prone to overdose, such as tricyclic antidepressants (imipramine or analogs) and acetaminophen. After these drugs are absorbed by the human body, they will be metabolized into small molecule substances, and these small molecule substances are present in body fluids such as blood, urine, saliva, sweat, etc. or some of the body fluids contain the above small molecule substances.

[0051] For example, the analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle-stimulating hormone, etc.), blood, white blood cells, sugar, heavy metals or toxins, bacterial substances (such as proteins or carbohydrate substances specific to certain bacteria, such as Escherichia coli O157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L. monocytogenes, Vibrio, or Bacillus cereus), and substances related to physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemical analysis can be performed using the lateral flow detection format in conjunction with the device of the present invention.

[0052] The cup body and the first cup lid

[0053] Refer to the appendix Figures 1 - 3 , A detachable detection device includes a cup body 10 and a first cover body 20. The first cover body 20 is used to cover the cup body 10. A first cavity 11 is provided inside the cup body 10. The first cavity 11 includes a first opening. The first cavity 11 can also be referred to as a detection cavity and is used to detect the analyte in the sample. When the first cover body 20 covers the cup body 10, the first cavity 11 is sealed to prevent the sample from leaking. Specifically, the cup body 10 and the first cover body 20 are connected by a threaded fit. A first retaining buckle 21 is provided on the first cover body 20, and a second retaining buckle 22 is provided on the cup body 10. When the cup body 10 and the first cover body 20 are exactly tightened, the first cavity 11 has been sealed at this time. At the same time, the first retaining buckle 21 abuts against the second retaining buckle 22, and the cup body 10 and the first cover body 20 cannot be tightened further. This design is to avoid the cup body 10 and the first cover body 20 being too tight due to continued screwing, which will cause unnecessary trouble for subsequent opening of the first cover body 20 for detection.

[0054] Preferably, a mark 23 is provided on the first cover body 20, and the mark 23 helps the operator distinguish the screwing direction of the first cover body 20.

[0055] The cup body and the sample bottle

[0056] Refer to the appendix Figures 2 - 4 , The detection device further includes a sample bottle 30. A second cavity 31 is provided inside the sample bottle 30. The second cavity 31 can also be referred to as a liquid storage cavity. By connecting the second cavity 31 with the first cavity 11 and allowing part of the sample to enter the second cavity for secondary detection. Specifically, refer to the appendix Figure 2 , appendix Figure 6 , The detection device includes two working states: upright and inverted. Appendix Figure 2 is upright. Appendix Figure 6It is inverted. The second chamber 31 includes a second opening, and the directions of the first opening and the second opening are opposite. When the detection device is in the upright state, the second chamber 31 is located above the first chamber 11. When there is no need to retain the sample, the sample in the first chamber 11 cannot enter the second chamber 31 under the action of gravity, avoiding contamination of the sample bottle 30. When the detection device is in the inverted state, the second chamber 31 is located below the first chamber 11. If the first chamber 11 and the second chamber 31 are connected at this time, the sample in the first chamber 11 can enter the second chamber 31 through the connection part for sample retention.

[0057] Refer to the appendix Figure 2 As shown, a first channel 24 is provided on the first cover body 20 of the detection device. The first channel 24 is in the shape of a hollow cylinder. The first cover body 20 is detachably connected to a sample bottle 30. The sample bottle 30 includes a bottle mouth 33. The first channel 24 extends into the bottle mouth 33, making the directions of the first opening and the second opening opposite. To avoid the sample bottle 30 being exposed to the outside and to fix the sample bottle 30 at the same time, preferably, the detection device further includes a third cover body 40. The third cover body 40 is detachably connected to the first cover body 20, for example, by means of screw threading. The space formed by assembling the third cover body 40 and the first cover body 20: a third chamber 41. The third chamber 41 wraps the sample bottle 30 inside. A fixing buckle 49 is provided inside the third cover body 40. The fixing buckle 49 is used to fix the sample bottle 30. Specifically, the bottle body contour of the sample bottle 30 is square, and there is a circular depression 32 provided thereon. There are also four fixing buckles 49, which are distributed in a square shape. There are raised strips 42 on the fixing buckles 49. The sample bottle 30 is detachably connected to the third cover body 40 through the fixing buckles 49 and the raised strips 42, realizing the detachable connection between the third cover body 40 and the sample bottle 30.

[0058] The sample bottle 30 is detachably connected to both the first cover body 20 and the third cover body 40. When the sample bottle 30 is removed, the first chamber 11 is separated from the second chamber 31. To achieve separate sealing of the sample bottle 30 after separation, a screw thread 34 is provided at the bottle mouth 33 position of the sample bottle 30. There is a vacant slot 27 on the third cover body 40. A hollow connecting column 25 is provided inside the vacant slot 27. A bottle cap 26 is sleeved on the connecting column 25. The bottle cap 26 is not easily detached from the connecting column 25. The operator can take out the bottle cap 26 by inserting a finger into the vacant slot 27. The bottle cap 26 is in screw-threaded engagement with the screw thread 34 of the bottle mouth 33. In this way, when the sample bottle 30 is removed, the sample bottle 30 can be sealed to avoid contamination of the sample reserved in the second chamber 31. At this time, the second chamber 31 is independent of the device and can be stored separately.

[0059] Sealing element between the cup body and the sample bottle

[0060] In the above connection method between the cup body 10 and the sample bottle 30, the first channel 24 always connects the first cavity 11 in the cup body 10 with the second cavity 31 in the sample 30, that is, the sample in the first cavity 11 is always connected with the sample in the second cavity 31. If the operator wants to retain a sample, just invert the detection device and wait for a while (usually from one second to ten seconds, not exceeding thirty seconds). At this time, the sample will enter the second cavity 31 through the first channel 24 under the action of gravity to complete sample retention. It should be noted that in fact, a new technical problem is brought at this time. Since the second opening of the second cavity 31 is opposite to the first opening: If the third cover body 40 is opened to take out the sample bottle 30 when the detection device is inverted, since the first opening of the first cavity 11 faces downward at this time, the sample in the first cavity 11 will continuously leak out from the first channel 24 when the sample bottle 30 is taken out; If the third cover body 40 is opened to take out the sample bottle 30 when the detection device is upright, at this time the first opening of the first cavity 11 faces upward. Although the sample in the first cavity 11 will not leak out, since the second opening of the sample bottle 30 faces downward at this time, the sample in the second cavity 31 will flow back into the first cavity 11 again under the action of gravity, resulting in insufficient retained sample. At the same time, the operator needs to quickly turn over the sample bottle 30 after removing the sample bottle 30 to make the second opening face upward. During this process, the sample in the second cavity 31 will spill out again. Therefore, a sealing element 50 needs to be provided between the cup body 10 and the sample bottle 30 to control the connection relationship between the first cavity 11 and the second cavity 31. When retaining a sample, the first cavity 11 and the second cavity 31 are connected, and when the sample bottle 30 is removed, the first cavity 11 and the second cavity 31 are separated.

[0061] Preferably, referring to the attached drawings, the sealing element 50 includes two working positions: the first working position and the second working position. When the sealing element 50 is in the first working position, the sealing element 50 is inserted into the first channel 24, and the first cavity 11 and the second cavity 31 are in a non-connected state; when the sealing element 50 is in the second working position, the sealing element 50 is separated from the first channel 24, and the first cavity 11 and the second cavity 31 are in a connected state. Specifically, the detection device further includes a second cover body 60. The sealing element 50 is connected to the second cover body 60, and the second cover body 60 is detachably connected to the cup body 10. Refer to the attached Figure 2, when the detection device is in the upright state, since the upper side of the cup body 10 is already provided with a first opening for connecting the first cover body 20, there is not enough space on the upper side of the cup body 10. The simplest way is to arrange the second cover body 60 on the lower part of the cup body 10. Further, a third opening 12 is provided at a position below the first cavity 11 inside the cup body 10, and the third opening 12 is detachably connected to the second cover body 60. Since the sealing element 50 is located inside the first cavity 11 and the second cover body 60 is located outside the first cavity 11, in order to enable the second cover body 60 to drive the sealing element 50 to move, a second channel 13 is provided on one side of the first cavity 11 close to the third opening 12. A rod body 61 is provided on the second cover body 60, and the rod body 61 passes through the second channel 13 to connect the sealing element 50. It should be noted that the contact position between the rod body 61 and the second channel 13 needs to be sealed, otherwise the sample inside the first cavity 11 will leak. Preferably, a first circular ring protrusion 14 is provided inside the second channel 13, and the first circular ring protrusion 14 can make the contact between the second channel 13 and the rod body 61 closer. Further, two first circular ring protrusions 14 are provided up and down inside the second channel 13. Similarly, the sealing element 50 needs to seal the first channel 24, and two second circular ring protrusions 52 are provided on the sealing element 50. The first circular ring protrusion 14 and the second circular ring protrusion 52 are both used to enhance the sealing effect, but there is a difference between the two. The first circular ring protrusion 14 is provided on the inner surface of the second channel 13, and the setting is relatively difficult and not easy to install; while the second circular ring protrusion 52 is located on the outer surface of the sealing element 50, and the setting is easy and the installation is simple. Preferably, annular grooves are provided on the inner surface of the second channel 13 and the outer surface of the sealing element 50, and the first circular ring protrusion 14 and the second circular ring protrusion 52 are made of silicone rubber or rubber seals to improve the sealing performance of the sealed position. Here is also an alternative technical solution: the first circular ring protrusion 14 and the second channel 13 are made of the same material, and the first circular ring protrusion 14 and the second channel 13 are integrally formed, which can solve the problem of difficult installation of the first circular ring protrusion 14 inside the second channel 13. By controlling the movement of the second cover body 50, the movement of the sealing element 50 can be controlled, and the movement of the sealing element 50 controls the switching between the communication state and the non-communication state of the first cavity 11 and the second cavity 31.

[0062] The following provides a supporting assembly and use method in combination with the detection device provided by the present invention, and in combination with the operation process, solves the problems that may be encountered during the use of the detection device, and provides some improvements in the detailed structure. First, assemble the detection device. Refer to the attached Figure 2, the operator first screws the first cover body 20 onto the cup body 10. When the first retaining buckle 21 abuts against the second retaining buckle 22, the installation of the first cover body 20 is completed. Subsequently, the sealing element 50 is assembled with the rod body 61 on the second cover body 60 to complete the fixation of the sealing element 50. The connection relationship between the sealing element 50 and the rod body 60 can be a spiral screwing type or an insertion type. Then, the rod body 61 passes through the second channel 13 to connect the second cover body 60 to the cup body 10. The connection relationship between the second cover body 60 and the cup body 10 can be a spiral screwing type or an insertion type. When the second cover body 60 covers the third opening 12 of the cup body 10, the sealing element 50 on the second cover body 60 seals the first channel 24 of the first cover body 20. Then, the sample bottle 30 is installed on the third cover body 40 through the fixing buckle 49, so that the bottle mouth 33 of the sample bottle 30 is aligned with and inserted into the first channel 24, and then the third cover body 40 is tightened, thus completing the assembly of the detection device.

[0063] During the above assembly process, in order to facilitate the sealing element 50 connected to the rod body 61 to enter the first channel 24, preferably, the sealing element 50 is conical, and the conical sealing element 50 has a guiding effect when entering the first channel 24.

[0064] The following specifically describes the usage method: Refer to the appendix Figures 5 - 12 , unscrew the first cover body 20, add a sample into the first cavity 11, and cover the first cover body 20, thus completing the sampling operation. Invert the detection device so that the second cavity 31 is located below the first cavity 11, open the second cover body 60, and the second cover body 60 drives the sealing element 50 to disengage from the first channel 24 through the rod body 61. At this time, the first cavity 11 and the second cavity 31 are in a communicating state, and the sample flows into the second cavity 31 through the first channel 24 under the action of gravity. Wait for a while. After the sample bottle 30 has collected the sample, cover the second cover body 60 and the cup body 10 again. At this time, the sealing element 50 moves into the first channel 24, and the first cavity 11 and the second cavity 31 are in a non-communicating state. The operator unscrews the third cover body 40, and the third cover body 40 drives the sample bottle 30 to leave the cup body 10 together. Since the sealing element 50 seals the first channel 24 at this time, the sample will not leak out from the first channel 24. The operator reaches into the empty slot 27 with a finger to take out the bottle cap 26, and then helically engages the bottle cap 26 with the screw thread 34 of the bottle mouth 33 to complete the sealing of the sample bottle 30, and takes out the sample bottle 30 from the third cover body 40, independent of the device. Then, fix the third cover body 40 back onto the cup body 10 and turn the detection device back, thus completing the reservation and extraction of the sample.

[0065] During the use of the above detection device, there is an operation of "opening the second cover body 60, and the second cover body 60 drives the sealing element 50 to disengage from the first channel 24 through the rod body 61". During this process, since there is a sample in the first chamber 11, in order to avoid violent shaking of the sample in the device, the second cover body 60 and the cup body 10 are preferably connected in a spiral screwing manner, rather than an insertion manner. The threaded screwing connection has the following advantages: when the second cover body 60 is separated from the cup body 10, it is relatively stable; while for the insertion connection, there is a large shaking when the second cover body 60 is separated from the cup body 10, which may cause the sample to spill out.

[0066] The above content also has an operation of "after the sample bottle 30 is filled with the sample, the sealing element 50 is moved into the first channel 24 again". Since when the sample bottle 30 is filled with the sample, the first channel 24 is also filled with the sample. If the sealing element 50 wants to enter the first channel 24 at this time, it is very difficult because the space is already occupied. Preferably, the sealing element 50 is conical and has holes 51 on its conical surface, and the inside of the sealing element 50 is hollow. With such a design, when the sealing element 50 is inserted into the first channel 24, part of the sample in the first channel 24 will enter the sealing element 50 through the holes 51. The departure of this part of the sample provides space for the entry of the sealing element 50. Further, in order to reserve enough space for the entering sample, the rod body 61 is hollow inside.

[0067] Preferably, the bottle cap 26 adopts a similar technical solution as above (the bottle cap 26 is fixed to the third cover body 40), and is fixed to the second cover body 60, which helps the operator remove the bottle cap 26 to seal the sample bottle 30 when the detection device is in an inverted state. It should be noted that at this time, the second cover body 40 needs to be designed slightly larger to allow the bottle cap 26 to be embedded in the second cover body 40 to avoid the bottle cap 26 affecting the placement stability of the detection device when it is in an upright state.

[0068] As described above, it is only the specific implementation manner of the invention, but the protection scope of the invention is not limited thereto. Any change or replacement that is thought of without creative labor, or some simple changes in the operation process, should be covered within the protection scope of the invention. Therefore, the protection scope of the invention should be subject to the protection scope defined by the claims.

[0069] The inventions shown and described herein can be practiced without any element, limitation, specific to this disclosure. The terms and expressions employed are used as terms of description and not of limitation, and are not intended to exclude any equivalents of the features shown and described or portions thereof, and it is recognized that various modifications are possible within the scope of the invention. Accordingly, it should be understood that although the invention has been specifically disclosed by way of various embodiments and optional features, modifications and variations of the concepts herein described may be resorted to by those of ordinary skill in the art, and that such modifications and variations are considered to fall within the scope of the invention as defined by the appended claims.

[0070] To the extent that the content of any article, patent, patent application, and all other literature and electronically available information described or cited herein is hereby incorporated by reference in its entirety, as if each individual publication were specifically and individually indicated to be incorporated by reference. The applicant reserves the right to incorporate into this application any and all materials and information from any such article, patent, patent application, or other literature.

Claims

1. A detachable detection device, characterized in that, It includes a cup body, a first cover detachably connected to the cup body, a first chamber located inside the cup body for collecting samples, and when the first cover covers the cup body, the first chamber is sealed; a sample bottle detachably connected to the first cover, and a second chamber located inside the sample bottle; a first channel is provided on the first cover for communicating the first chamber and the second chamber; The detection device includes two working states: upright and inverted; When the detection device is in the upright state, the second chamber is located above the first chamber; when the detection device is in the inverted state, the first chamber is located above the second chamber; and a movable sealing element; A second channel is provided on the lower side of the first chamber when the cup body is in the upright state; A second cover, the second cover is detachably connected to the cup body, a rod is provided on the second cover, and the rod passes through the second channel to connect the sealing element; The sealing element includes two working positions: a first working position and a second working position. When the sealing element is in the first working position, the sealing element is inserted into the first channel, and the first chamber and the second chamber are in a non-connected state; when the sealing element is in the second working position, the sealing element is separated from the first channel, and the first chamber and the second chamber are in a connected state.

2. The splitable detection device according to claim 1, characterized in that, The sealing element is detachable.

3. The split detection device according to claim 1, characterized in that, The sample bottle includes a bottle mouth, and the first channel extends into the bottle mouth.

4. The split-type detection device according to claim 1, characterized in that, The sealing element is conical, and a sealing ring is installed on the sealing element.

5. The splitable detection device according to claim 1, characterized in that, The inside of the sealing element is hollow, and holes are provided on the surface of the sealing element.

6. The splitable detection device according to claim 1, characterized in that, It further includes a third cover, the third cover is detachably connected to the first cover, the third cover is detachably connected to the sample bottle, and the space formed by assembling the third cover and the first cover wraps the sample bottle inside.

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