A circulation gap hypoxic animal cabin

Abstract

The problem to be solved by the present invention is to provide a cyclic intermittent hypoxic animal cabin with a compact structure, a small footprint, easy use, and meeting experimental requirements. The cabin comprises a support seat, a hypoxic cabin, and a rotating frame; the rotating frame is rotatably connected to the support seat, and at least one animal chamber is provided on the rotating frame; the hypoxic cabin is installed on the support seat, and when the rotating frame rotates, the animal chamber can cyclically enter and leave the hypoxic cabin.

Description

Technical Field

[0001] The invention relates to an animal hypoxia experimental device, in particular to a circulation gap hypoxia animal cabin. Background Art

[0002] Sleep apnea (OSA) is a serious sleep-related respiratory disorder characterized by intermittent hypoxia and sleep fragmentation caused by repeated upper airway obstruction or stenosis during sleep. In recent years, with the in-depth study of OSA, scholars from various countries have established different animal models based on its pathophysiological mechanisms. The most commonly used animal model is the rat model, which is established by placing the selected rats in an intermittent hypoxia device to create an intermittent hypoxic environment, and measuring various physiological parameters after a period of time.

[0003] The prior art (invention patent with publication number CN201157489) discloses a reciprocating intermittent hypoxic animal cabin, which includes a hypoxic cabin and two animal cabins; the animal cabins are fixed on both sides of the hypoxic cabin through animal cabin brackets, and the distance between the two animal cabins is less than the length of the hypoxic cabin; animal hatches matching the animal cabins are provided on both sides of the hypoxic cabin, and the animal cabins enter the hypoxic cabin through the animal hatches; a hypoxic cabin bracket is provided at the lower part of the hypoxic cabin, and the two are connected by matching pulley rails; a driving device is provided between the hypoxic cabin bracket and the hypoxic cabin to drive the hypoxic cabin to reciprocate between the two animal cabins; a control panel is provided on the hypoxic cabin bracket, and the driving device switch and control buttons are provided on the control panel. However, the defects of this technology are that the structure is complex, the floor space is occupied, and it is inconvenient to increase the experimental control group. Summary of the invention

[0004] The problem to be solved by the present invention is to provide a cyclic intermittent hypoxia animal cabin, which has a compact structure, occupies a small area, is easy to use and meets the experimental requirements.

[0005] The present invention is achieved through the following technical solutions:

[0006] A circulating intermittent hypoxic animal cabin, characterized in that it comprises a support seat, a hypoxic cabin and a rotating frame;

[0007] The rotating frame is rotatably connected to the support seat, and at least one animal compartment is provided on the rotating frame;

[0008] The hypoxia chamber is installed on the support seat, and when the rotating frame rotates, the animal chamber can cyclically enter and leave the hypoxia chamber.

[0009] Furthermore, the rotating frame is of an annular structure, the inner circle side of the rotating frame is fixed on the rotating shaft through a plurality of supporting rods, and the rotating shaft is swivel mounted on the bracket seat;

[0010] The rotating frame is evenly provided with 3-6 animal chambers along the circumferential direction; the top wall and / or side wall of each animal chamber is provided with a plurality of ventilation holes distributed in an array.

[0011] Furthermore, the hypoxic chamber is of an arc-shaped tubular structure, and is sleeved on the outer wall of the animal warehouse. The bottom of the hypoxic chamber is provided with a track groove allowing the support rod to pass through, and the inner wall of the hypoxic chamber and the outer wall of the animal warehouse form a sealed interlayer cavity. One end of the hypoxic chamber is provided with an air inlet pipe port connected to the interlayer cavity, and the other end is provided with an air outlet pipe port connected to the interlayer cavity. An oxygen concentration sensor is installed on the inner wall of the hypoxic chamber.

[0012] Furthermore, one end of the hypoxic chamber is an entrance and the other end is an exit, and both the entrance and the exit are provided with sealing gaskets; a hatch is hingedly provided on the side wall of the hypoxic chamber, and a drive motor I is installed on the outer wall of the hypoxic chamber, and an arc-shaped connecting rod is fixedly installed on the output shaft of the drive motor I, and the other end of the connecting rod is hinged on the hatch.

[0013] Furthermore, a one-way exhaust fan is installed on the top of the hypoxia chamber.

[0014] Furthermore, a driving motor II is installed at the lower part of the base, and the driving motor II drives the rotating shaft to rotate through a pulley and belt transmission assembly.

[0015] Furthermore, the bracket seat is a triangular structure, and the upper end of the bracket seat is fixedly mounted with the hypoxia chamber via a vertical plate.

[0016] The beneficial effects achieved by the present invention compared with the prior art are as follows;

[0017] 1. Through the rotation of the rotating frame, each animal chamber can be cycled into and out of the hypoxic chamber in turn, replacing the reciprocating animal chamber entering the hypoxic chamber in the prior art. Under the premise of ensuring the experimental effect, the overall structure can be more compact and occupy a small area, and multiple experimental control groups can be used according to the experimental needs; 2. The hypoxic chamber is an arc-shaped pipe structure and can be installed on the outer wall of the animal chamber to ensure that the animal chamber quickly reaches a hypoxic environment when it is in the hypoxic chamber;

[0018] 3. The coordination of the air inlet, air outlet and one-way exhaust fan can realize the rapid exhaust of air from the hypoxic chamber. The oxygen concentration in the hypoxic chamber is monitored in real time through the oxygen concentration sensor, thereby controlling the nitrogen intake and ensuring the stability of the hypoxic environment.

[0019] 4. The driving motor I controls the opening and closing of the cabin door through the connecting rod. When the rotating frame rotates, the cabin door opens, and when the rotating frame stops, the cabin door closes, thereby ensuring the sealing of the hypoxia cabin;

[0020] 5. The present invention has low manufacturing cost, is easy to use, and is more suitable for promotion and use in laboratories. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the three-dimensional structure of the circulating intermittent hypoxic animal cabin of the present invention;

[0022] Figure 2 This is a three-dimensional schematic diagram of the hypoxia chamber of the present invention;

[0023] Figure 3 for Figure 2 Schematic diagram of the internal structure;

[0024] Figure 4 for Figure 2 Schematic cross section;

[0025] In the figure: 1. bracket seat, 2. hypoxia chamber, 21. track groove, 22. air inlet pipe port, 23. air outlet pipe port, 24. sealing gasket, 25. one-way exhaust fan, 3. rotating frame, 4. rotating shaft, 5. driving motor II, 6. animal compartment, 7. hatch, 8. driving motor I, 9. connecting rod. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments of the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0027] In the description of the invention, it is necessary to understand that the terms "left", "right", "up", "down", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the invention.

[0028] like Figure 1-4As shown, this embodiment discloses a circulating intermittent hypoxic animal cabin, which mainly includes a support seat 1, a hypoxic cabin 2, a rotating frame 3 and a driving device. The support seat 1 is a triangular structure, which can not only increase stability but also save floor space. The rotating frame 3 is a circular ring structure, and the inner circle side of the rotating frame 3 is fixed to the rotating shaft 4 through a plurality of support rods, and the two ends of the rotating shaft 4 are swivel-mounted on the support seat 1 through a bearing assembly. The driving device includes a driving motor II 5 and a pulley belt transmission assembly, and the driving motor II 5 is installed at the bottom of the support seat 1 through a bolt assembly, which can increase stability. The pulley belt transmission assembly cooperates to install one end of the rotating shaft 4 and the output shaft of the driving motor II 5, so as to realize the function of the driving motor II 5 driving the rotating shaft 4 to rotate through the pulley belt transmission assembly. The rotating frame 3 is provided with four animal chambers 6 along the circumferential direction, and a plurality of array-distributed vents are provided on the top wall and side wall of each animal chamber 6.

[0029] The hypoxic chamber 2 is an arc-shaped tubular structure. The hypoxic chamber 2 is fixedly mounted on the upper end of the bracket seat 1 through a vertical plate. The hypoxic chamber 2 is sleeved on the outer wall of the animal chamber 6. A track groove 21 is processed at the bottom of the hypoxic chamber 2 to allow the support rod to pass through. With such a design, when the rotating frame rotates, the animal chamber 6 moves relative to the hypoxic chamber 2 without interference. The inner wall of the hypoxic chamber 2 and the outer wall of the animal chamber 6 form a sealed interlayer cavity. The left end of the hypoxic chamber 2 is processed with an air inlet port 22 connected to the interlayer cavity, and the right end is processed with an air outlet port 23 connected to the interlayer cavity. The air inlet port is connected to a nitrogen tank with a flow regulating valve. The inner wall of the hypoxic chamber 2 is installed with an oxygen concentration sensor and a temperature sensor. By being electrically connected to an external controller, the controller transmits the collected information to the display for observation. The temperature and oxygen concentration signal collection technology belongs to conventional means and is not described in detail here.

[0030] The left end of the hypoxic chamber 2 is the hatch entrance, and the right end is the hatch exit. Sealing gaskets 24 are installed at the hatch entrance and the hatch exit to ensure the sealing of the hypoxic chamber 2. The side wall of the hypoxic chamber 2 is hinged with a hatch door 7, and a drive motor Ⅰ8 is installed on the outer wall of the hypoxic chamber 2. The output shaft of the drive motor Ⅰ8 is fixedly installed with an arc-shaped connecting rod 9, and the other end of the connecting rod 9 is hinged on the hatch door 7. The driving motor Ⅰ8 drives the connecting rod 9 to rotate, thereby opening or closing the hatch door 7. In order to accelerate the exhaust of air in the hypoxic chamber 2, a one-way exhaust fan 25 is installed on the top of the hypoxic chamber 2.

[0031] Taking 20 rats randomly divided into four groups and alternately entering a hypoxic environment to conduct an intermittent hypoxia experiment as an example, the specific working process of the cyclic intermittent hypoxia animal chamber of the present invention is as follows:

[0032] Four groups of rats are placed in four animal chambers 6 respectively, the driving motor I8 controls the door 7 to be in an open state, the driving motor II5 drives the rotating frame 3 to rotate, so that the first animal chamber 6 enters the hypoxia chamber 2, and the driving motor I8 controls the door 7 to be closed, so that the hypoxia chamber 2 and the animal chamber 6 form a relatively sealed environment;

[0033] Nitrogen is filled into the hypoxic chamber from the air inlet 22, and the one-way exhaust fan works to rapidly reduce the oxygen concentration in the hypoxic chamber and the animal chamber 6. The oxygen concentration sensor monitors in real time to ensure that the oxygen value in the hypoxic chamber and the animal chamber 6 reaches the set level.

[0034] After the rats in the animal chamber 6 have been in the hypoxia chamber 2 for a period of time, the chamber door 7 is opened, and the rotating frame 3 rotates unidirectionally to allow the second animal chamber 6 to enter the hypoxia chamber, and the above steps are repeated.

[0035] The present invention can make the overall structure more compact and occupy a smaller area while ensuring the experimental effect, and can adopt multiple experimental control groups to conduct experiments according to experimental requirements, so the use is more flexible.

Claims

1. A cyclic intermittent hypoxic animal cabin, characterized in that: It includes a support base, a hypoxia chamber and a rotating frame; The rotating frame is rotatably connected to the support seat, and at least one animal compartment is provided on the rotating frame; The hypoxia chamber is installed on the support seat, and when the rotating frame rotates, the animal chamber can cyclically enter and leave the hypoxia chamber; The rotating frame is of an annular structure, the inner side of the rotating frame is fixed on the rotating shaft through a plurality of supporting rods, and the rotating shaft is swivel mounted on the bracket seat; The rotating frame is evenly provided with 3-6 animal chambers along the circumferential direction; the top wall and / or side wall of each animal chamber is provided with a plurality of ventilation holes distributed in an array; The hypoxia chamber is an arc-shaped tube cavity structure, the hypoxia chamber is sleeved on the outer wall of the animal warehouse, the bottom of the hypoxia chamber is provided with a track groove allowing the support rod to pass through, the inner wall of the hypoxia chamber and the outer wall of the animal warehouse form a sealed sandwich cavity, one end of the hypoxia chamber is provided with an air inlet pipe port connected to the sandwich cavity, and the other end is provided with an air outlet pipe port connected to the sandwich cavity, and the inner wall of the hypoxia chamber is installed with an oxygen concentration sensor; A driving motor II is installed at the lower part of the bracket seat, and the driving motor II drives the rotating shaft to rotate through a pulley belt transmission assembly.

2. The intermittent hypoxic animal cabin according to claim 1, characterized in that: One end of the hypoxic chamber is an entrance and the other end is an exit, and both the entrance and exit are provided with sealing gaskets; a hatch door is hinged on the side wall of the hypoxic chamber, and a drive motor I is installed on the outer wall of the hypoxic chamber, and an arc-shaped connecting rod is fixedly installed on the output shaft of the drive motor I, and the other end of the connecting rod is hinged on the hatch door.

3. The intermittent hypoxic animal cabin according to claim 1, characterized in that: A one-way exhaust fan is installed on the top of the hypoxia cabin.

4. The intermittent hypoxic animal cabin according to any one of claims 1 to 3, characterized in that: The support seat is a triangular structure, and the upper end of the support seat is fixedly mounted with the hypoxia chamber via a vertical plate.

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