Sample loading device, slide pusher and sample loading method

Abstract

The present application discloses a sample loading device for a slide pusher, comprising: a frame having an operating position; a drive mechanism mounted on the frame and connected to a sampling needle and a blood-dropping needle, for driving the sampling needle and / or the blood-dropping needle to move to the operating position for operation; wherein the central axes of the sampling needle and the blood-dropping needle are substantially parallel to the vertical direction; the operation of the sampling needle includes drawing a blood sample from a container on the operating position, and the blood-dropping needle and the sampling needle form a fluid channel, and the operation of the blood-dropping needle includes drawing a blood sample and / or loading the blood sample onto a glass slide on the operating position. The deviation of the central axes of the sampling needle and the blood-dropping needle from the vertical direction Y in the sample loading device provided in the embodiment of the present application is 0 to 5 degrees, thereby enabling the sampling needle and the blood-dropping needle to perform vertical operations along the vertical direction, facilitating control of the operating positions of the sampling needle and the blood-dropping needle and reducing precision requirements.

Description

Technical Field

[0001] The present invention relates to the technical field of biological sample analysis instruments, and in particular to a sample loading device, a slide pusher and a sample loading method. Background Art

[0002] During the blood smear preparation process, a sample loading device is first used to collect a certain amount of blood from a container storing the blood sample. The collected blood is then dripped onto a glass slide for subsequent smearing, staining, and analysis. However, existing sample loading devices typically include a sampling needle and a dripping needle. The sampling needle pierces the stopper of the blood storage container to enter the blood storage container and draw blood. The sampling needle and dripping needle are connected by a connecting hose, and a control valve is used to transfer the blood sample from the sampling needle to the dripping needle.

[0003] However, the sampling needle and the blood dropping needle in the prior art have high requirements for sampling accuracy during actual use, which is not conducive to improving the working efficiency of the film pusher. Summary of the Invention

[0004] The present application provides a sample loading device, a slide pusher and a sample loading method with low precision requirements.

[0005] In one aspect, an embodiment of the present application provides a sample loading device for a slide pusher, comprising:

[0006] A frame, wherein the frame is provided with an operating position;

[0007] A driving mechanism, which is mounted on the frame and connected to the sampling needle and the blood dropping needle, and is used to drive the sampling needle and / or the blood dropping needle to move to the operating position for operation;

[0008] Among them, the central axes of the sampling needle and the blood-dropping needle are roughly parallel to the vertical direction; the operation of the sampling needle includes sucking the blood sample from the container on the working position, the blood-dropping needle and the sampling needle form a fluid channel, and the operation of the blood-dropping needle includes sucking the blood sample and / or loading the blood sample onto the glass slide on the working position.

[0009] In which, the driving mechanism has a first driving part and a second driving part, the first driving part is installed on the frame, and the second driving part is installed on the first driving part, the first driving part is used to drive the second driving part to move to change the position of the second driving part in the first direction, the sampling needle and the blood dropping needle are both arranged on the second driving part, and the two are separated by a fixed distance. Under the drive of the second driving part, the sampling needle and the blood dropping needle move simultaneously along the second direction, wherein the first direction and the second direction are different.

[0010] The rack is further provided with an avoidance position, and when one of the sampling needle and the blood dropping needle descends to the operating position for operation, the other is located in the avoidance position.

[0011] In which, the operating position includes an automatic whole blood sampling position and a blood dropping position located inside the rack, the automatic whole blood sampling position is used to place the first container, and the blood dropping position is used to place the glass slide, the operation of the sampling needle includes puncturing and aspirating the first blood sample from the first container located on the automatic whole blood sampling position, the first blood sample aspirated by the sampling needle flows to the blood dropping needle through the fluid channel, and the operation of the blood dropping needle includes loading the first blood sample aspirated by the sampling needle onto the glass slide located at the blood dropping position.

[0012] Wherein, the sample loading device further includes a cleaning component, and the cleaning component cleans the blood dropping needle.

[0013] Among them, the cleaning component includes a cleaning container and a reaction liquid stored in the cleaning container, the operation position also includes a cleaning position, the cleaning position is provided with the cleaning container, and the operation of the blood drop needle also includes moving it to the cleaning container of the cleaning position for cleaning.

[0014] Wherein, the blood dripping position is located between the cleaning position and the automatic whole blood sampling position.

[0015] Wherein, the cleaning position is located between the automatic whole blood sampling position and the blood dropping position.

[0016] The cleaning component has a first swab, the blood-dropping needle passes through the first swab and can move relative to the first swab along the second direction, so that the first swab cleans the outer wall of the blood-dropping needle.

[0017] The operation position further includes a micro-sampling position inside the rack, and the operation of one of the sampling needle and the blood-dropping needle further includes drawing a second blood sample from a second container located on the micro-sampling position, and the operation of the blood-dropping needle further includes loading the second blood sample in the blood-dropping needle onto a glass slide located at the blood-dropping position.

[0018] The operation of the blood-dropping needle further includes sucking a second blood sample from a second container located on the micro-sampling position, so that the blood-dropping needle can load the second blood sample onto the glass slide on the blood-dropping position.

[0019] The micro-sampling position and the automatic whole blood sampling position are both the first position of the rack, and the sample loading device further comprises a sample rack, on which a plurality of sample seats are provided, and the sample seats are used to accommodate a first container and a second container, and can be moved in a direction close to the first position, wherein the first container located at the automatic whole blood sampling position is a vacuum container moved to the first position, and the second container located at the micro-sampling position is an open container moved to the first position.

[0020] In which, the sample loading device also includes an identification component and a controller. The identification component is used to identify the type of the container at the first position and send a type signal to the controller. The controller controls the sampling needle or the blood dropper to absorb the blood sample from the container at the first position according to the type signal.

[0021] Among them, the identification component includes a scanning module and a label provided on the container. The scanning module is used to scan the label on the container and send a type signal to the controller. The controller determines the type of the container according to the type signal and controls the sampling needle or the blood dropper to absorb the blood sample from the container at the first position.

[0022] The bottom wall of the second container has a recessed portion, and the identification component includes a probe provided on the sample seat. The probe is used to detect the structure of the bottom wall of the container at the first position and send a type signal to the controller. The controller determines the type of the container according to the type signal and controls the sampling needle or the blood dropper to absorb the blood sample from the container at the first position.

[0023] When the blood-dropping needle draws the blood sample from the second container located on the micro-sampling position, the sampling needle is located at the space-avoiding position close to the blood-dropping position.

[0024] In which, the operation position also includes a manual sampling position, and the manual sampling position is provided with a manually placed third container. The operation of one of the sampling needle and the blood dropping needle also includes drawing a third blood sample from the third container located on the manual sampling position, and the operation of the blood dropping needle also includes loading the third blood sample in the blood dropping needle onto a glass slide located at the blood dropping position.

[0025] The operation of the sampling needle also includes drawing a third blood sample from a third container located on the manual sampling position. The blood sample drawn by the sampling needle flows to the blood dropping needle through the fluid channel. The operation of the blood dropping needle also includes loading the blood sample drawn by the sampling needle onto a glass slide located on the blood dropping position.

[0026] The automatic whole blood sampling position is located between the manual sampling position and the blood dropping position. When the sampling needle is used to absorb the third blood sample from the third container located on the manual sampling position, the blood dropping needle is located in the avoidance position close to the automatic whole blood sampling position.

[0027] Wherein, when the sampling needle is used to absorb the third blood sample from the third container located on the manual sampling position, the blood dropping needle is located at a space-avoiding position between the manual sampling position and the automatic whole blood sampling position.

[0028] Wherein, when the sampling needle absorbs the third blood sample from the third container located on the manual sampling position, the blood dropping needle is located at a space-avoiding position between the automatic whole blood sampling position and the blood dropping position.

[0029] Wherein, when the sampling needle absorbs the first blood sample from the first container located on the automatic whole blood sampling position, the blood dropping needle is located at a space-avoiding position between the automatic whole blood sampling position and the manual sampling position.

[0030] The operation of the blood dropping needle further includes sucking a third blood sample from a third container located on the manual sampling position, and moving the blood dropping needle to load the third blood sample onto the glass slide on the blood dropping position.

[0031] The automatic whole blood sampling position is located between the manual sampling position and the blood dropping position. When the blood dropping needle absorbs the blood sample from the third container located on the manual sampling position, the sampling needle is located at the avoidance position and is closer to the automatic whole blood sampling position than the blood dropping needle.

[0032] The manual sampling position is located outside the frame, and the frame has a through hole connecting the outside of the frame and the inside of the frame. When one of the sampling needle and the blood dropping needle is used to absorb the third blood sample from the third container located on the manual sampling position, one of the sampling needle and the blood dropping needle extends to the outside of the frame through the through hole of the frame.

[0033] The first driving part is used to drive the second driving part to slide along the first direction, and the working position is arranged along the sliding track of the second driving part so that the sampling needle or the blood dropping needle can be aligned with the working position.

[0034] Wherein, the second driving unit includes:

[0035] a second mounting plate, mounted on the first driving part;

[0036] a screw rod assembly, one end of which is mounted on the second mounting plate;

[0037] A sliding assembly includes a slide rail and a slider, wherein the slide rail is mounted on the mounting plate, and the slider is slidably mounted on the slide rail;

[0038] A second motor is mounted on the second mounting plate and is transmission-connected to the other end of the lead screw assembly;

[0039] A loading assembly is installed on the slider and connected to the lead screw assembly. The sampling needle and the blood dropping needle are installed on the loading assembly.

[0040] The first driving part is used to drive the second driving part to rotate around a first rotation axis, and the working position is arranged along the rotation trajectory of the second driving part so that the sampling needle or the blood dropping needle can be aligned with the working position, wherein the first rotation axis is parallel to the second direction.

[0041] The line connecting the sampling needle and the rotation center of the second driving part coincides with the line connecting the blood dropping needle and the rotation center of the second driving part.

[0042] Wherein, a line connecting the sampling needle and the rotation center of the second driving part and a line connecting the blood dropping needle and the rotation center of the second driving part have a first preset angle.

[0043] Wherein, the driving mechanism includes:

[0044] a first driving mechanism, mounted on the frame, connected to the sampling needle and the blood dropping needle, and configured to drive the sampling needle and the blood dropping needle to move back and forth simultaneously in a first direction;

[0045] a second driving mechanism, mounted on the first driving mechanism and connected to the blood-dropping needle, for driving the blood-dropping needle to reciprocate along a second direction, wherein the first direction is different from the second direction;

[0046] The third driving mechanism is installed on the first driving mechanism, connected to the sampling needle, and is used to drive the sampling needle to move back and forth along the second direction.

[0047] Wherein, the first driving mechanism includes:

[0048] A first mounting plate, mounted on the frame;

[0049] a first motor, mounted on the first mounting plate;

[0050] The transmission assembly includes a driving wheel, a driven wheel and a conveyor belt. The driving wheel is located at one end of the first mounting plate and is connected to the first motor. The driven wheel is located at the other end of the first mounting plate. The conveyor belt is installed on the driving wheel and the driven wheel. The second drive mechanism is installed on the conveyor belt.

[0051] Wherein, the second driving mechanism includes:

[0052] a second mounting plate, mounted on the conveyor belt;

[0053] a first screw assembly, one end of which is mounted on the second mounting plate;

[0054] A first sliding assembly includes a first slide rail and a first slider, wherein the first slide rail is mounted on the second mounting plate, and the first slider is slidably mounted on the first slide rail;

[0055] a second motor, mounted on the second mounting plate and drivingly connected to the other end of the first screw assembly;

[0056] The first loading assembly is installed on the first sliding block and is connected to the first screw assembly. The blood dropping needle is installed on the first loading assembly.

[0057] Wherein, the first loading component includes:

[0058] The mounting kit includes a first mounting block for mounting the blood dropping needle and a first connecting block connected to the first mounting block, wherein the first mounting block is mounted on the first slider, and the first connecting block is connected to the first screw assembly;

[0059] A blood dropper mounting piece, movably mounted on the first mounting block;

[0060] The first elastic member has one end in contact with the blood dropping needle mounting member and the other end in contact with the mounting sleeve. The blood dropping needle can movably pass through the blood dropping needle mounting member and the first elastic member.

[0061] The first mounting block is provided with a mounting hole, the blood drop needle has a needle head, and the mounting kit further includes:

[0062] an abutment member, mounted on the mounting hole, wherein the blood drop needle mounting member can movably pass through the abutment member, and the other end of the first elastic member abuts against the abutment member;

[0063] The locking member is connected to the end of the blood-dropping needle mounting member facing away from the needle head.

[0064] Wherein, the first elastic member is a coil spring, and the elastic extension direction of the first elastic member is the same as the extension direction of the blood dropping needle.

[0065] The blood-dropping needle includes a needle having a first flow channel, and the first loading assembly includes:

[0066] a second mounting block, mounted on the first slider, and the blood-dropping needle is mounted on the second mounting block;

[0067] a second connecting block connected to the second mounting block and to the first screw assembly;

[0068] A second elastic member is installed at the needle head, and the second elastic member has a second flow channel communicated with the first flow channel.

[0069] Wherein, the third driving mechanism includes:

[0070] a second screw assembly, one end of which is mounted on the second mounting plate;

[0071] A second sliding assembly includes a second slide rail and a second slider, wherein the second slide rail is mounted on the second mounting plate, and the second slider is slidably mounted on the second slide rail;

[0072] a third motor, mounted on the second mounting plate and drivingly connected to the other end of the second screw assembly;

[0073] The second loading assembly is installed on the second sliding block and is connected to the second lead screw assembly. The sampling needle is installed on the second loading assembly.

[0074] Wherein, the second loading component includes:

[0075] a loading block, mounted on the second sliding block, and the sampling needle is mounted on the loading block;

[0076] A matching block is connected to the loading block and to the second lead screw assembly.

[0077] Wherein, the device further includes:

[0078] The flexible tube has two ends respectively connected to the sampling needle and the blood dropping needle.

[0079] Wherein, the device further includes:

[0080] a first swab, wherein the blood-dropping needle penetrates the first swab and is movable relative to the first swab along the second direction so that the first swab cleans the outer wall of the blood-dropping needle;

[0081] The second swab, the sampling needle passes through the second swab and can move relative to the second swab along the second direction so that the second swab cleans the outer wall of the sampling needle.

[0082] Wherein, the device further includes:

[0083] A control mechanism is used to control the operation of the air source mechanism, the first drive mechanism, the second drive mechanism and the third drive mechanism, so that the blood-dropping needle draws a blood sample and loads the blood sample onto a glass slide, or the sampling needle draws a blood sample and transports the blood sample to the blood-dropping needle to load the blood sample onto a glass slide.

[0084] In a second aspect, the embodiments of the present application further provide a slide pusher and a slide loading device for loading slides;

[0085] a sample loading device, wherein the blood-dropping needle of the sample loading device is used to draw a blood sample and load the blood sample onto the glass slide; or a sampling needle of the sample loading device is used to draw a blood sample and form a fluid channel for supplying the blood sample with the blood-dropping needle, so that the blood-dropping needle loads the blood sample onto the glass slide;

[0086] a slide pushing device for smoothing the blood sample on the slide to form a smear;

[0087] A staining device is used for staining the smear.

[0088] When the sampling needle draws a blood sample and the blood-dropping needle loads the blood sample, the first driving mechanism of the sample loading device and the third driving mechanism of the sample loading device drive the sampling needle to move to the first sampling position, the air source mechanism of the sample loading device is actuated to enable the sampling needle to draw a blood sample and deliver the blood sample to the blood-dropping needle, and the first driving mechanism and the second driving mechanism of the sample loading device drive the blood-dropping needle to move to the sample loading position so that the blood-dropping needle loads the blood sample onto the glass slide at the sample loading position;

[0089] When the blood-dropping needle absorbs the blood sample and loads the blood sample, the first driving mechanism and the second driving mechanism drive the blood-dropping needle to move to the second sampling position, the air source mechanism is activated to enable the blood-dropping needle to absorb the blood sample, and the first driving mechanism and the second driving mechanism drive the blood-dropping needle to move to the sample adding position, so that the blood-dropping needle loads the blood sample onto the glass slide at the sample adding position.

[0090] The first sampling bit is different from the second sampling bit; or the first sampling bit is the same as the second sampling bit.

[0091] Wherein, the device further includes:

[0092] The scanning device is used for scanning the barcode on the blood sample container and determining the type of the blood sample container according to the barcode.

[0093] In a third aspect, an embodiment of the present application further provides a sample loading method, which is applied to a slide pusher, wherein the slide pusher includes a sampling needle and a blood drop needle, wherein the automatic whole blood sampling position and the micro-sampling position in the slide pusher are located at the same preset position, and the method comprises:

[0094] Identifying an operation mode corresponding to the preset position, wherein the operation mode includes automatic whole blood sampling and micro sampling;

[0095] sending a type signal to the controller;

[0096] According to the operation mode, the sampling needle or the blood dropper is controlled to vertically absorb the blood sample from the container at the first position.

[0097] Wherein, “controlling the sampling needle or the blood dropper to vertically draw the blood sample from the container at the first position according to the operation mode” includes:

[0098] If it is determined that the operation mode at the preset position is automatic whole blood sampling, controlling the sampling to draw the blood sample from the container at the preset position;

[0099] If it is determined that the operation mode at the preset position is micro-sampling, the blood dropper is controlled to absorb the blood sample from the container at the preset position.

[0100] The deviation of the central axis of the sampling needle and the blood-dropping needle in the sample loading device and the slide pusher provided in the embodiment of the present application from the vertical direction Y is 0 to 5 degrees, so that the sampling needle and the blood-dropping needle can both operate vertically along the vertical direction, which is conducive to controlling the operating position of the sampling needle and the blood-dropping needle and reducing the accuracy requirements. BRIEF DESCRIPTION OF THE DRAWINGS

[0101] In order to more clearly illustrate the technical solution of the present invention, the following is a brief introduction to the drawings required for use in the implementation. Obviously, the drawings described below are only some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0102] Figure 1 is a schematic diagram of a sample loading device provided in Example 1 of the present application from a first perspective;

[0103] Figure 2 yes Figure 1 A schematic diagram of a sample loading device in another embodiment shown in a first perspective;

[0104] Figure 3 yes Figure 2 A schematic diagram of a second perspective of the sample loading device shown;

[0105] Figure 4 yes Figure 1 A schematic diagram of the sample loading device is shown;

[0106] Figure 5 yes Figure 4 A schematic diagram of a second perspective of the sample loading device shown;

[0107] Figure 6a yes Figure 4 The sample loading device is shown as a schematic diagram of a first perspective moving to above the blood dripping position;

[0108] Figure 6b yes Figure 6a A schematic diagram of a second perspective of the sample loading device shown;

[0109] Figure 7a Figure 6a Schematic diagram of the sample loading device for dripping blood;

[0110] Figure 7b yes Figure 7a A schematic diagram of a second perspective of the sample loading device shown;

[0111] Figure 8a yes Figure 4 The sample loading device shown is further provided with a schematic diagram of a cleaning position;

[0112] Figure 8b yes Figure 8a A schematic diagram of a second perspective of the sample loading device shown;

[0113] Figure 9 yes Figure 8a A schematic diagram showing the sample loading device being moved above the cleaning position;

[0114] Figure 10 yes Figure 9 Schematic diagram of the sample loading device shown for cleaning;

[0115] Figure 11 yes Figure 10 The schematic diagram of the sample loading device shown is moved above the blood dripping position;

[0116] Figure 12 yes Figure 11 The schematic diagram of the sample holder shown is used to drip blood in the device;

[0117] Figure 13a yes Figure 8a The sample loading device shown is further provided with a schematic diagram of a micro-sampling position;

[0118] Figure 13b yes Figure 13aA schematic diagram of a second perspective of the sample loading device shown;

[0119] Figure 14 is a schematic diagram of the sample loading device shown in FIG13 for performing micro-blood sampling;

[0120] Figure 15 yes Figure 13a A schematic structural diagram of the second container shown;

[0121] Figure 16a yes Figure 13a The sample loading device shown is further provided with a schematic diagram of a manual sampling position;

[0122] Figure 16b yes Figure 16a A schematic diagram of a second perspective of the sample loading device shown;

[0123] Figure 17a yes Figure 16a The schematic diagram of the sample loading device shown is lowered to the manual sampling position for sampling;

[0124] Figure 17b yes Figure 17a A schematic diagram of a second perspective of the sample loading device shown;

[0125] Figure 18 is a schematic diagram of a sample loading device provided in Example 2 of the present application;

[0126] Figure 19 is a schematic diagram of a sample loading device provided in Example 3 of the present application;

[0127] Figure 20 is a schematic diagram of a sample loading device provided in Example 4 of the present application;

[0128] Figure 21 is a schematic diagram of a sample loading device provided in Example 5 of the present application;

[0129] Figure 22 is a schematic diagram of a sample loading device provided in Example 6 of the present application;

[0130] Figure 23a is a schematic diagram of a sample loading device provided in Example 7 of the present application from a first perspective;

[0131] Figure 23b is a schematic diagram of a second perspective of the sample loading device shown in 23a;

[0132] Figure 24 is a schematic diagram of a sample loading device provided in Example 8 of the present application;

[0133] Figure 25is a schematic diagram of a sample loading device provided in Example 9 of the present application;

[0134] Figure 26 is a schematic diagram of a sample loading device provided in Example 10 of the present application;

[0135] Figure 27 is a schematic diagram of a sample loading device provided in Example 11 of the present application;

[0136] Figure 28 is a schematic diagram of a sample loading device provided in Example 12 of the present application;

[0137] Figure 29a is a schematic diagram of a sample loading device provided in Example 13 of the present application from a first perspective;

[0138] Figure 29b yes Figure 29a A schematic diagram of a second perspective of the sample loading device shown;

[0139] Figure 30 is a schematic diagram of a sample loading device provided in Example 14 of the present application;

[0140] Figure 31 is a flow chart of a sample loading method provided in an embodiment of the present application;

[0141] Figure 32 This is a structural diagram of a film pusher provided by an embodiment of the present invention from one angle;

[0142] Figure 33 yes Figure 32 Schematic diagram of the structure of the middle film pusher from another angle;

[0143] Figure 34 This is a partial schematic diagram of a slide pusher provided by an embodiment of the present invention, showing a slide loading device, a sample loading device, and a blood sample container. The blood sample container is a vacuum blood collection tube, and the sample collection mode is a manual sample collection mode.

[0144] Figure 35 yes Figure 34 Partial schematic diagram of the blood sample container, blood dropper and first swab;

[0145] Figure 36 This is a partial schematic diagram of a slide pusher provided by an embodiment of the present invention, showing a slide loading device, a sample loading device, and a blood sample container. The blood sample container is a micro-blood collection tube, and the sample collection mode is a manual sample collection mode.

[0146] Figure 37 yes Figure 36 Partial schematic diagram of the blood sample container, blood dropper and first swab;

[0147] Figure 38 This is a partial schematic diagram of a slide pusher provided by one embodiment of the present invention, showing a slide loading device, a sample loading device, and a blood sample container. The blood sample container is a micro blood collection tube, and the sample collection mode is an automatic sample collection mode.

[0148] Figure 39 yes Figure 38 Partial schematic diagram of the blood sample container, blood dropper and first swab;

[0149] Figure 40 This is a partial schematic diagram of a slide pusher provided by an embodiment of the present invention, showing a slide loading device, a sample loading device, and a blood sample container. The blood sample container is a vacuum blood collection tube, and the sample collection mode is an automatic sample collection mode.

[0150] Figure 41 yes Figure 40 Partial schematic diagram of the blood sample container, sampling needle and first swab of the middle slide pusher;

[0151] Figure 42 This is a partial schematic diagram of a slide pusher provided by an embodiment of the present invention, showing a slide loading device, a sample loading device, and a blood drop needle located at a sample loading position;

[0152] Figure 43 yes Figure 42 A partial schematic diagram of the middle film pusher, showing the sampling needle, the blood drop needle, the second drive mechanism and the third drive mechanism;

[0153] Figure 44 yes Figure 43 Partial schematic diagram in;

[0154] Figure 45 yes Figure 44 An exploded schematic diagram of the first loading assembly in FIG;

[0155] Figure 46 yes Figure 45 A schematic structural diagram of the abutment member of the first loading assembly;

[0156] Figure 47 yes Figure 43 A schematic structural diagram of the second loading assembly in FIG;

[0157] Figure 48 It is a schematic block diagram of a film pusher provided in one embodiment of the present application. DETAILED DESCRIPTION

[0158] The technical solutions in the embodiments of the present invention will be described clearly and completely below with reference to the accompanying drawings in the embodiments of the present invention.

[0159] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application include direct and indirect connections (couplings) unless otherwise specified. In the description of this application, it should be understood that the orientations or positional relationships indicated by the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", etc. are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to this application.

[0160] In this application, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Furthermore, when a first feature is "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0161] Please refer to Figures 1 to 3 , a sample loading device 1 provided in Example 1 of the present application, includes a frame 101 and a driving mechanism 102, wherein the frame 101 is provided with an operating position A; the driving mechanism 102 is installed on the frame 101 and is connected to a sampling needle 103 and a blood dropping needle 104, and is used to drive the sampling needle 103 and / or the blood dropping needle 104 to move to the operating position A for operation; wherein, the central axes of the sampling needle 103 and the blood dropping needle 104 are roughly parallel to the vertical direction Y; the operation of the sampling needle 103 includes sucking a blood sample from a container on the operating position A, the blood dropping needle 104 and the sampling needle 103 form a fluid channel L, and the operation of the blood dropping needle 104 includes sucking a blood sample and / or loading the blood sample onto the glass slide 202 of the operating position A.

[0162] like Figure 1 As shown, the working position A of the rack 101 can be the position where the sample loading device 1 performs various operations. For example, the working position A can be the position where a blood sample is placed; for another example, the working position A can be the position where a slide 202 is placed; for another example, the working position A can be the position where a cleaning device is placed, etc. The working position A of the rack 101 can be located inside the rack 101 or outside the rack 101.

[0163] like Figure 1 As shown, after the sampling needle 103 and the blood-dropping needle 104 are installed on the driving mechanism 102, the deviation between the central axis of the sampling needle 103 and the blood-dropping needle 104 and the vertical direction Y is 0 to 5 degrees, so that the sampling needle 103 and the blood-dropping needle 104 can both perform vertical operations along the vertical direction, which is conducive to controlling the operating positions of the sampling needle 103 and the blood-dropping needle 104 and reducing the accuracy requirements.

[0164] The driving mechanism 102 is used to drive the sampling needle 103 and / or the blood-dropping needle 104 to move to the working position A for operation. It can be understood that the driving mechanism 102 can simultaneously drive the sampling needle 103 and the blood-dropping needle 104 to move to the working position A for operation; it can also drive the sampling needle 103 and the blood-dropping needle 104 to move to the working position A for operation separately. In some embodiments, such as Figure 2 As shown, the driving mechanism 102 has a first driving part 1021 and a second driving part 1022. The first driving part 1021 is mounted on the frame 101, and the second driving part 1022 is mounted on the first driving part 1021. The first driving part 1021 is used to drive the second driving part 1022 to move, so as to change the position of the second driving part 1022 in a first direction. Optionally, the first direction is a first horizontal direction X1, which is perpendicular to the vertical direction Y. For example, Figure 1 As shown, taking the sampling needle 103 for sampling as an example, the first driving part 1021 of the driving mechanism 102 can drive the sampling needle 103 to move to the position along the horizontal direction. When the sampling needle 103 is at the position a, it is aligned with the required working position A. Then, the second driving part 1022 of the driving mechanism 102 drives the sampling needle 103 to move to the working position A along the vertical direction Y. For another example, Figure 2 As shown, the first driving portion 1021 of the driving mechanism 102 can drive the sampling needle 103 to rotate around the vertical direction Y so that the sampling needle 103 moves to position a. When the sampling needle 103 is at position A, it is aligned with the desired working position A, as shown in FIG. Figure 2 As shown, the second driving portion 1022 of the driving mechanism 102 then drives the sampling needle 103 to move along the vertical direction Y to the working position A. The trajectory of the blood drop needle 104 during operation can be the same as that of the sampling needle 103, which will not be repeated here.

[0165] Please refer to Figure 1 , Figure 1 The sampling needle 103 and the blood-dropping needle 104 in the sample loading device 1 are both mounted on the second drive unit 1022 and spaced a fixed distance apart. Driven by the second drive unit 1022, the sampling needle 103 and the blood-dropping needle 104 move simultaneously along a second direction, wherein the first direction and the second direction are different. It is understood that the first direction may be the horizontal direction X1, and the second direction may be the vertical direction Y.

[0166] The sampling needle 103 and the blood dropping needle 104 are jointly arranged on a driving part, namely the second driving part 1022, so that the second driving part 1022 can simultaneously drive the sampling needle 103 and the blood dropping needle 104 to move along the vertical direction Y. In other words, the sampling needle 103 and the blood dropping needle 104 can move up and down at the same time, which simplifies the driving control of the sampling needle 103 and the blood dropping needle 104. In addition, the distance between the sampling needle 103 and the blood dropping needle 104 is a fixed distance, so that the length of the pipeline connecting the sampling needle 103 and the blood dropping needle 104 only needs to be slightly greater than or equal to the distance between the sampling needle 103 and the blood dropping needle 104. The fluid channel L formed by the sampling needle 103 and the blood dropping needle 104 is shorter, so that the transportation path of the blood sample from the sampling needle 103 to the blood dropping needle 104 through the fluid channel L is shorter, and the blood sample is not easily diluted, thereby reducing the amount of blood sample aspirated.

[0167] For example, Figure 1 As shown, the first driving unit 1021 is used to drive the second driving unit 1022 to slide along the first direction, and the working position A is arranged along the sliding track of the second driving unit 1022, so that the sampling needle 103 or the blood dropping needle 104 can be aligned with the working position A. Specifically, when the sampling needle 103 or the blood dropping needle 104 needs to perform an operation, the first driving unit 1021 drives the second driving unit 1022 to slide along the horizontal direction so that the sampling needle 103 or the blood dropping needle 104 can be aligned with the corresponding operation. Then, under the drive of the second driving unit 1022, the sampling needle 103 or the blood dropping needle 104 can be simultaneously lowered so that the sampling needle 103 or the blood dropping needle 104 reaches the corresponding working position A.

[0168] In one embodiment, Figures 4 and 5 In the illustrated embodiment, the rack 101 is further provided with an avoidance position C. When one of the sampling needle 103 and the blood dropping needle 104 is lowered to the working position A for operation, the other is located at the avoidance position C.

[0169] It should be noted that the avoidance position C of the rack 101 can be understood as a position in the rack 101 where no device is installed. It can also be understood that when one of the sampling needle 103 or the blood drop needle 104 is operating, the position of the other will not interfere with other devices, so the position that is collided can be understood as the avoidance position C.

[0170] In this embodiment, the sampling needle 103 and the blood dropping needle 104 are enabled to move up and down together along the vertical direction Y, and a clearance position C is provided in the frame 101. On the one hand, the driving mechanism 102 of the sampling needle 103 and the blood dropping needle 104 in the vertical direction Y is simplified, thereby reducing the cost. On the other hand, when the sampling needle 103 and the blood dropping needle 104 descend at the same time, they will not interfere with other devices, thereby ensuring the reliable operation of the sample loading device 1.

[0171] like Figure 4 In the illustrated embodiment, the working position A includes an automatic whole blood sampling position A1 and a blood dropping position A2 located inside the rack 101. The automatic whole blood sampling position A1 is used to place the first container 201, and the blood dropping position A2 is used to place the glass slide 202. The operation of the sampling needle 103 includes puncturing and aspirating the first blood sample from the first container 201 located on the automatic whole blood sampling position A1. The first blood sample aspirated by the sampling needle 103 flows to the blood dropping needle 104 through the fluid channel L. The operation of the blood dropping needle 104 includes loading the first blood sample aspirated by the sampling needle 103 onto the glass slide 202 located at the blood dropping position A2.

[0172] Optional, please refer to Figure 5 The sample loading device 1 also includes a sample rack 105, which is provided with a plurality of sample seats 1051. The sample seats 1051 are used to accommodate a plurality of first containers 201. The plurality of first containers 201 can automatically move in a direction close to the first position, wherein the first container 201 located at the automatic whole blood sampling position A1 is a vacuum container moved to the first position.

[0173] Among them, such as Figure 4 and Figure 5 As shown, the first container 201 is a vacuum blood collection tube. In other words, it has a lid. The movement direction of the sample rack 105 is perpendicular to the first horizontal direction X1 and the vertical direction Y, which is the second horizontal direction X2. Automatic sampling is performed by providing the sample rack 105, and the movement trajectory of the sample rack 105 is a straight line, which reduces the space required by the sample loading device 1. Of course, in other embodiments, the movement direction of the sample rack 105 can also rotate about the vertical direction Y. The sample holders 1051 on the sample rack 105 can sequentially reach the first position as the sample rack 105 rotates, facilitating the descent of the sampling needle 103 to this position to sample the vacuum blood collection tube.

[0174] Optional, such as Figure 5As shown, the first container 201 at the first position and the glass slide 202 at the blood dripping position A2 are arranged along the sliding trajectory of the first driving unit 1021, that is, the first horizontal direction X1. In one embodiment, the blood dripping needle 104 is located to the left of the sampling needle 103. In other words, the sampling needle 103 is closer to the automatic whole blood sampling position A1 than the blood dripping needle 104. This allows the sampling needle 103 to move to the automatic whole blood sampling position A1 more quickly for sampling, thereby improving the sampling efficiency of the sampling needle 103 when collecting whole blood in the sample loading device 1.

[0175] Optional, such as Figure 4 As shown, the sample loading device 1 further includes a second swab 103a. The sampling needle 103 penetrates the second swab 103a and is movable relative to the second swab 103a in a vertical direction Y, allowing the second swab 103a to clean the outer wall of the sampling needle 103. Specifically, the second swab 103a can move axially relative to the sampling needle 103 to clean the outer wall of the sampling needle 103. The second swab 103a automatically cleans the outer wall of the sampling needle 103, thereby removing any residual blood sample from the outer wall of the sampling needle 103 without the need for wiping with a paper towel, thereby reducing biological risks and the probability of pore blockage.

[0176] like Figures 4 to 7a As shown, the working process of the sample loading device 1 in this embodiment of loading whole blood onto the glass slide 202 can be:

[0177] Sampling needle 103 sampling: Figure 4 As shown, the first drive unit 1021 drives the second drive unit 1022 to slide horizontally until the sampling needle 103 is located above the automatic whole blood sampling position A1. The second drive unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously, so that the sampling needle 103 punctures the lid of the first container 201 and draws the first blood sample from the first container 201. At this time, the blood dropping needle 104 is in the clearance position C between the housing and the automatic whole blood sampling position A1, which is defined as the first clearance position C.

[0178] Cleaning the outer wall of the sampling needle 103: driving the second swab 103a to move axially relative to the sampling needle 103 to clean the blood sample that may remain on the outer wall of the sampling needle 103. It is understandable that this cleaning step can also be performed before the sampling needle 103 takes a sample.

[0179] The blood drop needle 104 drops the sample: the sampling needle 103 transfers the sucked blood sample to the blood drop needle 104 through the fluid channel L. Figure 6a and Figure 6b As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to rise simultaneously along the vertical direction Y, and the first driving unit 1021 drives the second driving unit 1022 to move until the blood dropping needle 104 is located above the blood dropping position A2, i.e., above the glass slide 202. Figure 7a and Figure 7b As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously along the vertical direction Y, the blood dropping needle 104 moves to the blood dropping position A2, and loads the blood sample onto the glass slide 202 of the blood dropping position A2. At this time, the sampling needle 103 is located between the avoidance position C between the housing and the blood dropping position A2, which is defined here as the second avoidance position C2.

[0180] Further, such as Figure 8a As shown, the sample loading and cleaning device further includes a cleaning component 106, which is used to clean the blood-dropping needle 104. It is understood that the cleaning component 106 can clean the blood-dropping needle 104 in at least one of the following states: before dropping the sample, after dropping the sample, before aspirating the sample, and after aspirating the sample, thereby ensuring that the blood sample ultimately loaded onto the glass slide 202 by the blood-dropping needle 104 is a clean and uncontaminated blood sample, further improving the reliability of the sample loading device 1.

[0181] In one embodiment, Figure 8a As shown, the cleaning assembly 106 includes a cleaning container 1061 and a reaction solution stored in the cleaning container 1061. The operation position A also includes a cleaning position A3, which is equipped with the cleaning container 1061. The operation of the blood-dropping needle 104 also includes moving it to the cleaning container 1061 in the cleaning position A3 for cleaning. Specifically, the blood-dropping needle 104 can be inserted into the cleaning container 1061 for cleaning under the drive mechanism 102. The structure of the cleaning assembly 106 ensures reliable cleaning of the blood-dropping needle 104.

[0182] Further, such as Figure 8a As shown, the cleaning assembly 106 further includes a first swab 1062. The blood-dropping needle 104 passes through the first swab 1062 and is movable relative to the first swab 1062 in a second direction, so that the first swab 1062 cleans the outer wall of the blood-dropping needle 104. Specifically, the structure of the first swab 1062 can be identical to that of the second swab 103a. The first swab 1062 is disposed on the blood-dropping needle 104, enabling cleaning of the outer wall of the blood-dropping needle 104 without occupying the cleaning position A3 within the housing. Optionally, the first swab 1062 and the cleaning container 1061 can be used for cleaning in different scenarios. Of course, in other embodiments, the first swab 1062 and the cleaning container 1061 can be used for the same cleaning scenario. For example, before blood is dripped from the blood-dropping needle 104, the outer wall of the blood-dropping needle 104 can be cleaned using the first swab 1062, and then moved to the cleaning container 1061 for further cleaning.

[0183] In this embodiment, Figure 8bAs shown, the blood dripping position A2 is located between the cleaning position A3 and the automatic whole blood sampling position A1. Specifically, the first avoidance position C1, the automatic whole blood sampling position A1, the blood dripping position A2, the cleaning position A3 and the second avoidance position C2 are arranged in sequence along the sliding track of the second driving part 1022. When the blood dripping needle 104 is inserted into the cleaning container 1061 for cleaning, the sampling needle 103 can be located in the second avoidance position C2. In other words, the relative position relationship between the blood dripping needle 104 and the sampling needle 103 is combined with the setting method of the blood dripping position A2 so that there is no need to reserve a position inside the rack 101 to set the avoidance position C of the sampling needle 103 when the blood dripping needle 104 is performing the cleaning operation, which is conducive to the miniaturization of the sample loading device 1 and further optimizes the structure of the sample loading device 1.

[0184] The working process of the sample loading device 1 in this embodiment of loading whole blood onto the glass slide 202 may be:

[0185] Sampling needle 103 sampling: Figure 8a As shown, the first drive unit 1021 drives the second drive unit 1022 to slide along the first horizontal direction X1 until the sampling needle 103 is located above the automatic whole blood sampling position A1. The second drive unit 1022 then drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously, allowing the sampling needle 103 to puncture the lid of the first container 201 and aspirate the first blood sample from the first container 201. At this point, the blood dropping needle 104 is in a clearance position C between the housing and the automatic whole blood sampling position A1, defined herein as a first clearance position C1.

[0186] Cleaning the outer wall of the sampling needle 103: driving the second swab 103a to move axially relative to the sampling needle 103 to clean the blood sample that may remain on the outer wall of the sampling needle 103. It is understandable that this cleaning step can also be performed before the sampling needle 103 takes a sample.

[0187] Clean the outer wall of the blood dropping needle 104: Figure 9 As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to rise simultaneously along the vertical direction Y, and the first driving unit 1021 drives the second driving unit 1022 to move until the blood dropping needle 104 is located above the cleaning position A3, that is, the cleaning container 1061. Figure 10 As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously along the vertical direction Y, and the blood dropping needle 104 extends into the cleaning container 1061 for cleaning. At this time, the sampling needle 103 is located at the second avoidance position C2.

[0188] Blood drop needle 104 drops of sample: Figure 11As shown, the sampling needle 103 transfers the sucked blood sample to the blood dropping needle 104 through the fluid channel L. The second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to rise simultaneously along the vertical direction Y, and the first driving unit 1021 drives the second driving unit 1022 to move until the blood dropping needle 104 is located at the blood dropping position A2, that is, above the glass slide 202. Figure 12 As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously along the vertical direction Y, the blood dropping needle 104 moves to the blood dropping position A2, and loads the blood sample onto the glass slide 202 at the blood dropping position A2. At this time, the sampling needle 103 is located at the second air avoidance position C2.

[0189] Clean the outer wall of the blood drop needle 104: Please refer to Figures 9 and 10 , the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to rise simultaneously along the vertical direction Y, and the first driving unit 1021 drives the second driving unit 1022 to move until the blood dropping needle 104 is located above the cleaning position A3, i.e., the cleaning container 1061. The second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously along the vertical direction Y, and the blood dropping needle 104 is inserted into the cleaning container 1061 for cleaning. At this time, the sampling needle 103 is located in the second avoidance position C2. Optionally, the outer walls of the blood dropping needle 104 and the sampling needle 103 can be further cleaned by the first swab 1062 and the second swab 103a, respectively, to further ensure that the blood sample finally loaded by the blood dropping needle 104 onto the glass slide 202 is a clean and uncontaminated blood sample.

[0190] The sample loading device 1 provided in the embodiment of the present application further provides a cleaning component 106 to ensure that the blood sample ultimately loaded onto the glass slide 202 by the blood dropper 104 is a clean and uncontaminated blood sample, thereby improving the reliability of the sample loading device 1 .

[0191] Further, such as Figure 13a The sample loading device 1 shown is used as an example for explanation. The operation position A of the sample loading device 1 also includes a micro-sampling position A4 located inside the rack 101. The operation of one of the sampling needle 103 and the blood dropping needle 104 also includes aspirating a second blood sample from a second container located on the micro-sampling position A4. The operation of the blood dropping needle 104 also includes loading the second blood sample in the blood dropping needle 104 onto the glass slide 202 located at the blood dropping position A2.

[0192] In this embodiment, Figure 13aAs shown, the operation of the blood-dropping needle 104 also includes sucking the second blood sample from the second container 203 located on the micro-sampling position A4, so that the blood-dropping needle 104 can load the second blood sample onto the glass slide 202 of the blood-dropping position A2. In other words, sampling at the micro-sampling position A4 is achieved by the blood-dropping needle 104. It should be noted here that the blood sample taken at the micro-sampling position A4 has a smaller sampling volume than the blood sample taken at the automatic whole blood sampling position A1, and the blood sample taken at the micro-sampling position A4 is suitable for preparation of small sample volumes. The second container 203 storing a trace amount of blood is generally an open container, which is conducive to the blood-dropping needle 104 to perform rapid sampling and dripping, reduce the consumption and dilution of blood samples, and reduce the demand for sample suction volume, thereby achieving micro-sampling and priority sampling.

[0193] Understandably, Figure 13b As shown, the micro-sampling position A4 and the automatic whole blood sampling position A1 are both the first positions of the rack 101, and the sample holder 1051 is also used to accommodate the first container 201 and the second container 203, and can be moved in a direction close to the first position, wherein the second container 203 located at the micro-sampling position A4 is an open container moved to the first position. Figure 14 As shown, when the blood-dropping needle 104 is sampling a trace amount of blood at the first position, the sampling needle 103 is located at a clearance position C between the automatic whole blood sampling needle 103 and the blood-dropping position A2, herein defined as the third clearance position C3. By arranging the micro-sampling position A4 and the automatic whole blood sampling position A1 at the same location within the housing 101, the device volume is further reduced, facilitating miniaturization of the sample loading device 1. Of course, in other embodiments, the micro-sampling position A4 and the automatic whole blood sampling position A1 can also be located at different locations within the housing 101, for example, they can be located on either side of the third clearance position C.

[0194] It is understood that the sample loading device 1 also includes an identification component and a controller. The identification component is used to identify the type of container in the first position and send a type signal to the controller. The controller controls the sampling needle 103 or the blood drop needle 104 to draw the blood sample from the container in the first position according to the type signal. In other words, when the container on the sample rack 105 moves to the first position, the identification component can identify the type of the container, thereby determining whether the sampling needle 103 or the blood drop needle 104 is to be used for sampling a trace amount of blood. By further providing an automatic identification component to identify the type of container, the sampling mode of the sample loading device 1 can be automatically and quickly switched between the trace blood sampling mode and the automatic whole blood sampling mode, further improving the degree of automation of the sample loading device 1.

[0195] In an optional embodiment, the identification component includes a scanning module and a label on the container. The scanning module is configured to scan the label on the container and transmit a type signal to the controller. The controller determines the type of the container based on the type signal and controls the sampling needle 103 or the blood drop needle 104 to draw a blood sample from the container at the first position. For example, if the scanning device scans the label on the container and determines the container type based on the label, if the container is determined to be the first container 201, i.e., a vacuum blood collection tube, the sampling needle 103 draws the blood sample and transfers it to the blood drop needle 104, which then loads the blood sample onto the slide 202 at the blood drop position A2. If the container is determined to be the second container 203, i.e., an open container, the blood sample is directly drawn by the blood drop needle 104 and loaded onto the slide 202. It should be noted here that since the second blood sample in the second container 203 is generally small, when the blood dropping needle 104 draws the second blood sample from the second container 203, the bottom of the blood dropping needle 104 usually needs to contact the bottom of the second container 203 to ensure full utilization of the second blood sample in the second container 203.

[0196] In another optional embodiment, Figure 15 As shown, the bottom wall 2031 of the second container 203 has a recess 2032. The identification component includes a probe disposed on the sample holder 1051. The probe is used to detect the structure of the bottom wall of the container in the first position and send a type signal to the controller. The controller determines the type of the container based on the type signal and controls the sampling needle 103 or the blood dropper 104 to draw a blood sample from the container in the first position. For example, the bottom wall 2031 of the first container 201 is relatively small along the vertical direction Y. In other words, the bottom wall of the first container 201 is relatively thin. The thin bottom wall facilitates the first container 201 to store a larger amount of sample while also distinguishing it from the second container 203, which has a thicker bottom wall 2031 and a recess 2032. Combined with the detection of the bottom wall of each container by the probe on each sample holder 1051, the type of the second container 203 can be determined. It should be noted that the thicker bottom wall 2031 of the second container 203 allows the blood dropper 104 to contact the bottom wall 2031 of the second container 203 without having to descend a large distance, which facilitates the blood dropper 104 to quickly sample trace amounts of blood.

[0197] The working process of the sample loading device 1 in the embodiment of the present application may be:

[0198] Detect the container type at the first position: e.g. Figure 13bAs shown, when the container on the sample rack 105 moves to the first position, the identification component can identify the type of the container, thereby determining one of the sampling needle 103 and the blood drop needle 104 for sampling; the container at the first position is described as the second container 203;

[0199] Blood drop needle 104 sampling: Figure 13a As shown, the first driving unit 1021 drives the second driving unit 1022 to slide horizontally until the blood drop needle 104 is located above the micro-sampling position A4. Figure 14 As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously so that the blood dropping needle 104 passes through the second container 203 to absorb the second blood sample in the second container 203. At this time, the sampling needle 103 is in the third avoidance position C3.

[0200] Clean the outer wall of the blood dropping needle 104: Figure 13a As shown, the first swab 1062 is driven to move axially relative to the sampling needle 103 to clean the blood sample that may remain on the outer wall of the blood dropping needle 104 .

[0201] Cleaning the blood drop needle 104: Figures 9 and 10 As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to rise simultaneously along the vertical direction Y, and the first driving unit 1021 drives the second driving unit 1022 to move until the blood dropping needle 104 is located above the cleaning position A3, that is, the cleaning container 1061, and the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously along the vertical direction Y, and the blood dropping needle 104 moves to the cleaning position A3, and the blood dropping needle 104 discharges part of the blood sample from the needle tip.

[0202] Blood drop needle 104 drops of sample: Figures 11 to 12 As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to rise simultaneously along the vertical direction Y, and the first driving unit 1021 drives the second driving unit 1022 to move until the blood dropping needle 104 is located above the blood dropping position A2, that is, the glass slide 202. The second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously along the vertical direction Y, and the blood dropping needle 104 moves to the blood dropping position A2 and loads the blood sample onto the glass slide 202 at the blood dropping position A2. At this time, the sampling needle 103 is located between the avoidance position C between the casing and the blood dropping position A2, which is defined here as the second avoidance position C2.

[0203] It is understandable that after the blood dropper 104 loads the blood sample onto the glass slide 202 , the previous steps of cleaning the blood dropper 104 can be repeated, which will not be described in detail here.

[0204] The sample loading device 1 of this embodiment further samples a trace amount of blood through the blood dropping needle 104, which facilitates the blood dropping needle 104 to perform rapid sampling and sample dropping, reduces the consumption and dilution of blood samples, and reduces the demand for sample aspiration volume, thereby achieving micro-sampling and priority sampling.

[0205] Further, such as Figure 16a The sample loading device 1 shown is used as an example for explanation. The operation position A of the sample loading device 1 also includes a manual sampling position A5. The manual sampling position A5 is provided with a manually placed third container 204. The operation of one of the sampling needle 103 and the blood dropping needle 104 also includes drawing a third blood sample from the third container 204 located on the manual sampling position A5. The operation of the blood dropping needle 104 also includes loading the third blood sample in the blood dropping needle 104 onto the glass slide 202 located at the blood dropping position A2.

[0206] It should be noted that the manual sampling position A5 can be set outside the rack 101 or inside the rack 101. In other words, the setting of the manual sampling position A5 needs to be convenient for the staff to place the third container 204 and to facilitate the sampling needle 103 or the blood drop needle 104 to draw blood. Figure 16a As shown, the manual sampling position A5 is located outside the rack 101. The rack 101 has a through hole connecting the outside of the rack 101 and the inside of the rack 101. When one of the sampling needle 103 and the blood-dropping needle 104 is used to draw a third blood sample from the third container 204 located at the manual sampling position A5, the sampling needle 103 or the blood-dropping needle 104 extends into the interior of the rack 101 through the through hole of the rack 101. By further providing the manual sampling position A5 in the sample loading device 1, the requirements of priority sampling scenarios can be met, further improving the reliability of the sample loading device 1. In addition, by arranging the manual sampling position A5 outside the rack 101, the size of the rack 101 is reduced, which is beneficial to the reliability of the sample loading device 1.

[0207] In this embodiment, Figure 16a As shown, the operation of the blood-dropping needle 104 also includes aspirating a third blood sample from a third container 204 located at the manual sampling position A5, and moving the blood-dropping needle 104 to load the third blood sample onto the glass slide 202 at the blood-dropping position A2. The blood-dropping needle 104 further collects the third blood sample from the manual sampling position A5, which increases the function of the blood-dropping needle 104 while allowing the third blood sample to be directly loaded onto the glass slide 202 at the blood-dropping position A2 through the blood-dropping needle 104. This reduces blood sample consumption and dilution, and reduces the amount of sample aspirated, thereby achieving priority sampling of the third blood sample.

[0208] Optional, such as Figure 17bAs shown, the automatic whole blood sampling position A1 is located between the manual sampling position A5 and the blood dripping position A2. When the blood dripping needle 104 draws the blood sample from the third container 204 located on the manual sampling position A5, the sampling needle 103 is located at the avoidance position C and is closer to the automatic whole blood sampling position A1 than the blood dripping needle 104. In other words, Figure 17a As shown, when the blood-dropping needle 104 is located at the manual sampling position A5, the sampling needle 103 is located at the first avoidance position C1. In other words, the manual sampling position A5, the first avoidance position C1, the automatic whole blood sampling position A1, the third avoidance position C3, the blood-dropping position A2, the cleaning position A3, and the second avoidance position C2 are sequentially arranged along the sliding track of the second driving part 1022. The arrangement track of the multiple working positions A and the relative position relationship between the sampling needle 103 and the blood-dropping needle 104 (i.e., the blood-dropping needle 104 is located on the left side of the sampling needle 103) enable the blood-dropping needle 104 to be quickly moved to the manual sampling position A5 for sampling.

[0209] The working process of the sample loading device 1 in the embodiment of the present application at the manual sampling position A5 can be:

[0210] Blood drop needle 104 sampling: Figure 16a As shown, the first driving unit 1021 drives the second driving unit 1022 to slide horizontally until the blood drop needle 104 is located above the manual sampling position A5. Figure 17a As shown, the second driving unit 1022 drives the sampling needle 103 and the blood dropping needle 104 to descend simultaneously so that the blood dropping needle 104 passes through the through hole of the frame 101 to absorb the third blood sample in the third container 204. At this time, the sampling needle 103 is in the first avoidance position C1;

[0211] Cleaning the outer wall of the blood drop needle 104: refer to Figures 13a to 14 The step of “cleaning the outer wall of the blood-dropping needle 104 ” of the sample loading device 1 in the illustrated embodiment will not be described in detail here;

[0212] Cleaning the blood drop needle 104: refer to Figures 13a to 14 The step of “cleaning the blood-dropping needle 104 ” of the sample loading device 1 in the illustrated embodiment will not be described in detail here;

[0213] Blood drop needle 104 drops of sample: please refer to Figures 13a to 14 The step of “the blood-dropping needle 104 dripping sample” of the sample loading device 1 in the illustrated embodiment will not be described in detail here.

[0214] It is understandable that after the blood dropper 104 loads the blood sample onto the glass slide 202 , the previous steps of cleaning the blood dropper 104 can be repeated, which will not be described in detail here.

[0215] The sample loading device 1 provided in the embodiment of the present application further samples the blood sample on the manual sampling position A5 through the blood dropping needle 104, which is conducive to the rapid sampling and dripping of the third blood sample on the manual sampling position A5, reduces the consumption and dilution of the blood sample, and reduces the demand for sample aspiration volume, thereby achieving priority sampling of the third blood sample.

[0216] In an optional embodiment, as Figure 17b As shown, the distance between the sampling needle 103 and the blood dropping needle 104 along the horizontal direction is smaller than the distance between two adjacent positions in the manual sampling position A5, the automatic whole blood sampling position A1, and the blood dropping position A2, which is conducive to the miniaturization of the driving mechanism 102.

[0217] In an optional embodiment, the second driving portion 1022 includes a second mounting plate, a screw assembly, a sliding assembly, a second motor and a loading assembly, and the second mounting plate is mounted on the first driving portion 1021. One end of the screw assembly is mounted on the second mounting plate. The sliding assembly includes a slide rail and a slider, the slide rail is mounted on the mounting plate, and the slider is slidably mounted on the slide rail. The second motor is mounted on the second mounting plate and is transmission-connected to the other end of the screw assembly. The loading assembly is mounted on the slider and connected to the screw assembly, and the sampling needle 103 and the blood drop needle 104 are mounted on the loading assembly.

[0218] Specifically, the first drive unit 1021 includes a first mounting plate, a first motor, and a transmission assembly. The first mounting plate is mounted on the frame 101, the first motor is mounted on the first mounting plate, and the transmission assembly includes a driving wheel, a driven wheel, and a conveyor belt. The driving wheel is located at one end of the first mounting plate and is transmission-connected to the first motor. The driven wheel is located at the other end of the first mounting plate. The conveyor belt is mounted on the driving wheel and the driven wheel. The second drive mechanism 102 is mounted on the conveyor belt. The driven wheel is located at the other end of the first mounting plate, and the conveyor belt is mounted on the driving wheel and the driven wheel. The second drive unit 1022 is mounted on the conveyor belt.

[0219] It can be understood that the first motor can drive the driving wheel to rotate forward or reverse, so that the conveyor belt moves in the positive or negative direction of the first direction, that is, the horizontal direction, so that the second driving part 1022 on the conveyor belt moves back and forth in the first direction, that is, the horizontal direction.

[0220] Specifically, the second mounting plate is mounted on the conveyor belt of the transmission assembly. One end of the screw assembly and the motor are both mounted on the mounting plate, and the other end of the screw assembly is transmission-connected to the second motor. In this way, the screw assembly and the second motor can be fixed to the second mounting plate, and the second motor can drive the screw assembly to operate.

[0221] Specifically, the sliding assembly includes a slide rail and a slider, the slide rail is mounted on the second mounting plate, and the slider is slidably mounted on the slide rail. Specifically, the slide rail extends along the second direction, that is, the vertical direction Y.

[0222] Specifically, the loading assembly is mounted on the slider, and the loading assembly is connected to the lead screw assembly. The sampling needle 103 and the blood drop needle 104 are simultaneously mounted on the loading assembly. The second motor drives the loading assembly to reciprocate along the second direction through the lead screw assembly.

[0223] Please refer to Figure 18 , is a sample loading device 2 provided in Example 2 of the present application. The structure of this sample loading device 2 is roughly the same as that of the sample loading device 1 provided in Example 1 of the present application. The main difference is that the cleaning position A3 is located between the automatic whole blood sampling position A1 and the blood dropping position A2. In other words, the manual sampling position A5, the automatic whole blood sampling position A1, the cleaning position A3, and the blood dropping position A2 are arranged in sequence along the sliding trajectory of the second driving unit 1022, that is, the first horizontal direction X1. When the sampling needle 103 or the blood dropping needle 104 takes a blood sample and moves horizontally under the drive of the first driving unit 1021, the blood dropping needle 104 will first pass through the cleaning position A3 for cleaning. After cleaning, it will continue to move along the previous movement direction under the drive of the first driving unit 1021 to the top of the blood dropping position A2 and then descend to the blood dropping position A2 to drop the sample. The relative positions of the automatic whole blood sampling position A1, the cleaning position A3 and the blood dropping position A2 enable the sample loading device 2 to move in the same horizontal direction during the three operations of sampling, cleaning and blood dropping, thereby improving the efficiency of the sample loading device 2.

[0224] Please refer to Figure 19 , a sample loading device 3 provided in the third embodiment of the present application, has substantially the same structure as the sample loading device 1 provided in the first embodiment of the present application, differing primarily in that the cleaning position A3 is omitted and the first swab 1062 is used to clean the blood dropper 104 instead of the cleaning container 1061. This reduces the size of the sample loading device 3 and facilitates its miniaturization.

[0225] The outer wall of the blood-dropping needle 104 is cleaned in the first swab 1062 . Optionally, if the blood-dropping needle 104 is sampling and the blood sample at the needle tip needs to be removed, the blood sample is removed from the first swab 1062 .

[0226] Please refer to Figure 20, is a sample loading device 4 provided in Example 4 of the present application. The structure of the sample loading device 4 is roughly the same as that of the sample loading device 1 provided in Example 1 of the present application. The main difference is that the operation of the sampling needle 103 also includes sucking the second blood sample from the second container 203 located on the micro-sampling position A4. The second blood sample sucked by the sampling needle 103 flows to the blood dropping needle 104 through the fluid channel L.

[0227] Further, such as Figure 20 As shown, the operation of the sampling needle 103 also includes sucking a third blood sample from a third container 204 located at the manual sampling position A5. The blood sample sucked by the sampling needle 103 flows to the blood dropping needle 104 through the fluid channel L. The operation of the blood dropping needle 104 also includes loading the blood sample sucked by the sampling needle 103 onto the glass slide 202 located at the blood dropping position A2. When the sampling needle 103 is used to suck a blood sample from the manual sampling position A5, the blood dropping needle 104 can be located at the first clearance position C1 between the frame 101 and the automatic whole blood sampling position A1, or at the third clearance position C3 between the automatic whole blood sampling position A1 and the blood dropping position A2.

[0228] It should be noted that the sampling needle 103 collects a trace amount of blood or the third blood sample in substantially the same manner as the sampling needle 103 collects whole blood, and thus will not be described in detail herein.

[0229] Optionally, when the sampling needle 103 draws the second blood sample from the second container 203 located at the micro-sampling position A4, the blood-dropping needle 104 is located at the clearance position C near the blood-dropping position A2, i.e., the third clearance position C3. In other words, the sampling needle 103 is located to the left of the blood-dropping needle 104, closer to the manual sampling position A5. The arrangement of the multiple working positions A, and the relative positional relationship between the sampling needle 103 and the blood-dropping needle 104 (i.e., the sampling needle 103 is located to the left of the blood-dropping needle 104), enable the sampling needle 103 to be quickly moved to the manual sampling position A5 for sampling.

[0230] Please refer to Figure 21 , a sample loading device 5 provided in the fifth embodiment of the present application, has substantially the same structure as the sample loading device 4 provided in the third embodiment of the present application, differing primarily in that the cleaning position A3 is omitted and the first swab 1062 is used to clean the blood dropper 104 instead of the cleaning container 1061. This reduces the size of the sample loading device 5 and facilitates its miniaturization.

[0231] The outer wall of the blood-dropping needle 104 is cleaned in the first swab 1062 .

[0232] Please refer to Figure 22, a sample loading device 6 is provided in Example 6 of the present application. This sample loading device 6 has substantially the same structure as the sample loading device 1 provided in Example 1 of the present application, differing primarily in that the manual sampling position A5 is located within the rack 101. For example, the rack 101 has a cover that a worker can open to place the third container 204 within the rack 101. By locating the manual sampling position A5 within the rack 101, this sample loading device 6 reduces the possibility of contamination of the third container 204, thereby further improving the reliability of the sample loading device 6.

[0233] Please refer to Figure 23a , is a sample loading device 7 provided in Example 7 of the present application. This sample loading device 7 has a substantially identical structure to the sample loading device 1 provided in Example 1 of the present application, with the main difference being that the first drive unit 1021 is used to drive the second drive unit 1022 to rotate about a first rotation axis, and the operating position A is arranged along the rotation trajectory of the second drive unit 1022 so that the sampling needle 103 or the blood drop needle 104 can be aligned with the operating position A, wherein the first rotation axis is parallel to the second direction. In other words, the first drive unit 1021 of the drive mechanism 102 can drive the sampling needle 103 to rotate about the vertical direction Y so that the sampling needle 103 moves to position A. When the sampling needle 103 is at position A, it is aligned with the desired operating position A. Then, the second drive unit 1022 of the drive mechanism 102 drives the sampling needle 103 to move along the vertical direction Y to the operating position A.

[0234] Optional, such as Figure 23b As shown, the line connecting the sampling needle 103 to the rotation center of the second drive unit 1022 coincides with the line connecting the blood-dropping needle 104 to the rotation center of the second drive unit 1022. In one embodiment, the length of the line connecting the sampling needle 103 to the rotation center of the second drive unit 1022 is less than the length of the line connecting the blood-dropping needle 104 to the rotation center of the second drive unit 1022. In other words, the sampling needle 103 is closer to the rotation center of the second drive unit 1022 than the blood-dropping needle 104. The distance between the sampling needle 103 and the blood-dropping needle 104 is the difference between the lengths of the line connecting the sampling needle 103 to the rotation center of the second drive unit 1022 and the length of the line connecting the blood-dropping needle 104 to the rotation center of the second drive unit 1022.

[0235] For example, Figure 23bAs shown, the operation of the sampling needle 103 includes sucking the first blood sample from the automatic whole blood sampling position A1. The operation of the blood dropping needle 104 includes sucking at least one of the second blood sample from the micro sampling position A4 and the third blood sample from the manual sampling position A5. It can be understood that the manual sampling position A5, the micro sampling position A4, the blood dropping position A2 and the cleaning position A3 are arranged along the rotation trajectory of the blood dropping needle 104 on the second driving part 1022, so that the blood dropping needle 104 can be located above the manual sampling position A5, the micro sampling position A4, the blood dropping position A2 and the cleaning position A3. Among them, the micro sampling position A4 and the manual sampling position A5 can both be located in the same position. The type of container manually placed by the staff determines whether it is a trace of blood, whole blood or probe liquid.

[0236] It can be understood that the automatic whole blood sampling position A1 is arranged along the rotation trajectory of the sampling needle 103, so that the sampling needle 103 can be located above the automatic whole blood sampling position A1, so that the sampling needle 103 can take the first blood sample on the automatic whole blood sampling position A1.

[0237] The sample loading device 7 provided in the embodiment of the present application drives the second driving part 1022 to perform circular motion through the first driving part 1021 to change the horizontal positions of the sampling needle 103 and the blood dropping needle 104, so that the various working positions A inside the sample loading device 7 can be arranged in a circle, which is conducive to the miniaturization of the sample loading device 7.

[0238] Please refer to Figure 24 , a sample loading device 8 is provided in Example 8 of the present application. This sample loading device 8 has a substantially identical structure to the sample loading device 7 provided in Example 7 of the present application, differing primarily in that the cleaning position A3 is located between the automatic whole blood sampling position A1 and the blood dropping position A2. In other words, the automatic whole blood sampling position A1, cleaning position A3, and blood dropping position A2 are sequentially arranged along the rotational trajectory of the second drive unit 1022. After the sampling needle 103 or the blood dropping needle 104 collects a blood sample and rotates along the vertical direction Y driven by the first drive unit 1021, the blood dropping needle 104 first passes through the cleaning position A3 for cleaning. After cleaning, it continues to rotate along the previous direction of motion under the drive of the first drive unit 1021 to above the blood dropping position A2 and then descends to the blood dropping position A2 for sample dripping. The relative positions of the automatic whole blood sampling position A1, cleaning position A3, and blood dropping position A2 enable the sample loading device 8 to rotate horizontally in the same direction during the three operations of sampling, cleaning, and blood dripping, thereby improving the efficiency of the sample loading device 8.

[0239] Please refer to Figure 25, a sample loading device 9 provided in Example 9 of the present application, has substantially the same structure as the sample loading device 7 provided in Example 7 of the present application, differing primarily in that this sample loading device 9 eliminates the cleaning position A3 and utilizes a first swab 1062 to clean the blood dropper 104 instead of the cleaning container 1061. This reduces the size of the sample loading device 9 and facilitates its miniaturization.

[0240] The outer wall of the blood-dropping needle 104 is cleaned in the first swab 1062 . Optionally, if the blood-dropping needle 104 is sampling and the blood sample at the needle tip needs to be removed, the blood sample is removed from the first swab 1062 .

[0241] Please refer to Figure 26 , a sample loading device 10 provided in Example 10 of the present application, has substantially the same structure as the sample loading device 7 provided in Example 7 of the present application, differing primarily in that a line connecting the sampling needle 103 and the rotation center of the second drive unit 1022 and a line connecting the blood drop needle 104 and the rotation center of the second drive unit 1022 form a first predetermined angle d. The relative positions of the blood drop needle 104 and the sampling needle 103 facilitate their installation on the second drive unit 1022.

[0242] Please refer to Figure 27 , is a sample loading device 11 provided in the eleventh embodiment of the present application. The structure of the sample loading device 11 is substantially the same as that of the sample loading device 10 provided in the tenth embodiment of the present application. The main difference is that the cleaning position A3 is located between the automatic whole blood sampling position A1 and the blood dropping position A2. In other words, the automatic whole blood sampling position A1, the cleaning position A3, and the blood dropping position A2 are arranged in sequence along the rotation trajectory of the second driving unit 1022. When the sampling needle 103 or the blood dropping needle 104 rotates along the vertical direction Y under the drive of the first driving unit 1021 after taking the blood sample, the blood dropping needle 104 will first pass through the cleaning position A3 for cleaning. After cleaning, it will continue to rotate along the previous movement direction under the drive of the first driving unit 1021 to the top of the blood dropping position A2 and then descend to the blood dropping position A2 to drop the sample. The relative positions of the automatic whole blood sampling position A1, the cleaning position A3 and the blood dropping position A2 enable the sample loading device 11 to rotate horizontally along the same rotation direction during the three operations of sampling, cleaning and blood dropping, thereby improving the efficiency of the sample loading device 11.

[0243] Please refer to Figure 28The sample loading device 12 provided in the twelfth embodiment of the present application has substantially the same structure as the sample loading device 10 provided in the tenth embodiment of the present application. The main difference is that the sample loading device 12 eliminates the cleaning position A3 and uses a first swab to clean the blood dropper 104 instead of the cleaning container. This reduces the size of the sample loading device 12 and facilitates its miniaturization.

[0244] The outer wall of the blood-dropping needle 104 is cleaned in the first swab. Optionally, if the blood-dropping needle 104 is sampled and the blood sample at the needle tip needs to be removed, the blood sample is removed in the first swab.

[0245] Please refer to Figure 29a and Figure 29b , is a sample loading device 13 provided in Example 13 of the present application. The structure of this sample loading device 13 is substantially the same as that of the sample loading device 10 provided in Example 10 of the present application. The main difference is that the length of the line connecting the sampling needle 103 to the rotation center of the second drive unit 1022 is greater than the length of the line connecting the blood dropping needle 104 to the rotation center of the second drive unit 1022. In other words, the blood dropping needle 104 is closer to the rotation center of the second drive unit 1022 than the sampling needle 103. The distance between the sampling needle 103 and the blood dropping needle 104 is the difference between the lengths of the line connecting the sampling needle 103 to the rotation center of the second drive unit 1022 and the length of the line connecting the blood dropping needle 104 to the rotation center of the second drive unit 1022.

[0246] For example, Figure 29b As shown, the operation of the sampling needle 103 includes drawing at least one of the first blood sample from the automatic whole blood sampling position A1, the second blood sample from the micro sampling position A4, and the third blood sample from the manual sampling position A5. It can be understood that the manual sampling position A5, the micro sampling position A4, and the automatic sampling position are arranged along the rotation trajectory of the sampling needle 103 on the second drive unit 1022, so that the sampling needle 103 can be located above the manual sampling position A5, the micro sampling position A4, and the automatic sampling position. Among them, the micro sampling position A4 and the manual sampling position A5 can both be located in the same position. The type of container manually placed by the staff determines whether it is a trace of blood, whole blood, or probe liquid.

[0247] It can be understood that the blood dropping position A2 and the cleaning position A3 are arranged along the rotation trajectory of the blood dropping needle 104, so that the blood dropping needle 104 can be located above the blood dropping position A2 and the cleaning position A3 to realize the operation of the blood dropping needle 104.

[0248] Please refer to Figure 30, a sample loading device 14 is provided in the fourteenth embodiment of the present application. This sample loading device 14 has substantially the same structure as the sample loading device 7 provided in the seventh embodiment of the present application, differing primarily in that the manual sampling position A5 is located within the rack 101. For example, the rack 101 has a cover that a worker can open to place the third container 204 within the rack 101. By locating the manual sampling position A5 within the rack 101, this sample loading device 14 reduces the possibility of contamination of the third container 204, thereby further improving the reliability of the sample loading device 14.

[0249] Please refer to Figure 31 , is a sample loading method 1000 provided in an embodiment of the present application, and the sample loading method 1000 can be applied to Figure 13a The sample loading device 1 shown. The sample loading method 1000 includes:

[0250] 110: Identify an operation mode corresponding to the preset position, wherein the operation mode includes an automatic whole blood sampling mode and a micro sampling mode.

[0251] The operation mode corresponding to the first position can be identified by identifying the type of container at the first position; wherein the preset position can be as follows Figure 13a The sample loading device 1 is in the first position.

[0252] The operation mode corresponding to the first position can also be identified by scanning the barcode of the container located at the first position.

[0253] Specific, combined Figures 13a to 14 As shown, when the container on the sample rack 105 moves to the first position, the recognition component in the sample loading device 1 can identify the operating mode of the first position; the controller of the sample loading device 1 determines that one of the sampling needle 103 and the blood drop needle 104 is to collect the blood sample at the first position. The sample loading device 1 provided in the embodiment of the present application uses the recognition component to identify the operating mode at the first position, and can automatically and quickly switch the sampling mode, i.e., the operating mode, of the sample loading device 1 between the trace blood sampling mode and the automatic whole blood sampling mode, further improving the degree of automation of the sample loading device 1.

[0254] It should be noted that the specific identification method in step 110 can refer to the relevant content recorded in the above embodiment and will not be repeated here.

[0255] 120: Control the sampling needle or the blood dropper to vertically aspirate the blood sample from the container at the first position according to the operation mode.

[0256] Optionally, if it is determined that the operation mode at the preset position is automatic whole blood sampling, the sampling is controlled to absorb the blood sample from the container at the preset position; if it is determined that the operation mode at the preset position is micro sampling, the blood drop is controlled to absorb the blood sample from the container at the preset position. Figures 13a to 14 As shown, if it is determined that the type of the container at the first position is the first container 201, that is, the vacuum blood collection tube, the sampling needle 103 is controlled to absorb the blood sample and transfer it to the blood dropping needle 104, and the blood dropping needle 104 loads the blood sample onto the glass slide 202 at the blood dropping position A2; if it is determined that the type of the container at the first position is the second container 203, that is, the open container, the blood dropping needle 104 is controlled to absorb the blood sample and load the blood sample onto the glass slide 202.

[0257] It is understandable that if Figures 13a to 14 As shown, the sampling needle 103 or the blood dropping needle 104 vertically draws the blood sample from the container at the first position, which can be understood as the central axis direction of the sampling needle 103 and the blood dropping needle 104 is parallel to the vertical direction Y.

[0258] One embodiment of the present application provides a slide pusher that can be used to prepare smears from biological samples such as blood and body fluids. Such biological samples include, but are not limited to, microorganisms, blood, body fluids, and bone marrow fluid. To more clearly illustrate the inventive concept of this application, the following description uses blood as an example. This slide pusher includes, but is not limited to, the sample loading device described in the preceding embodiments.

[0259] See also Figure 32 and Figure 33 In one embodiment of the present application, a slide pusher is provided for preparing smears from biological samples such as blood samples. The slide pusher includes a slide loader 10a for loading slides and moving them to a working line, a sample loader 20 for aspirating a blood sample and loading it onto a slide, a slide pusher 30 for smoothing the blood sample on the slide to prepare a smear, and a staining device 40 for staining the smear.

[0260] See also Figure 32 and Figure 33 The slide loading device 10a extracts the slide and loads it into the appropriate position to facilitate the blood dripping operation. In some embodiments, after the slide extraction operation is completed, operations such as slide left and right inspection and slide cleaning can be performed before the slide is loaded. After the slide is loaded, relevant information can be printed and operations such as front and back inspection of the slide can be performed simultaneously.

[0261] See also Figure 32 、 Figure 33 、 Figure 41 、 Figure 42 and Figure 44In some embodiments, before drawing a blood sample, the blood sample is first mixed, and then the sampling mechanism (e.g., sampling needle 21) of the sample loading device 20 moves to a first sampling position to draw the blood sample. The sampling mechanism and the sample loading mechanism (e.g., blood dropper 22) of the sample loading device 20 form a fluid channel for supplying the blood sample, thereby allowing the blood drawn by the sampling mechanism to be transported to the sample loading mechanism. The sample loading mechanism moves to the sample loading position and loads the blood sample onto a glass slide at this position, making it suitable for preparing slides with larger sample volumes. Depending on the type of blood sample container 70, sample drawing can be performed by puncture, i.e., the blood sample container 70 has a lid, and the sampling mechanism can draw the sample through the lid of the blood sample container 70. Of course, sample drawing can also be performed by open sampling, i.e., the blood sample container 70 is open, and the sampling mechanism draws the sample directly from the open portion. Exemplarily, the types of blood sample containers 70 include vacuum blood collection tubes and micro blood collection tubes, and the sampling mechanism can draw the sample by puncturing the lid of the vacuum blood collection tube or the lid of the micro blood collection tube.

[0262] It is understood that in the above embodiment, the blood sample container 70 placed by the operator can be moved directly toward the sampling mechanism, or the sampling mechanism can be moved toward the test tube placed by the operator. The sampling mechanism draws the blood sample and then transfers it to the sample loading mechanism, which then loads the blood sample.

[0263] See also Figure 32 、 Figure 33 、 Figure 34 、 Figure 42 and Figure 43 In other embodiments, before drawing the blood sample, the blood sample is first mixed, and then the sample loading mechanism (such as the blood dropper 22) of the sample loading device 20 moves to the second sampling position to draw the blood sample. After drawing the blood sample, the sample loading mechanism moves to the sample loading position, and loads the blood sample onto the glass slide at the sample loading position. The sampling and loading of the blood sample can be completed by the sample loading mechanism. Since the blood sample does not need to be drawn by the sampling mechanism before flowing to the sample loading mechanism, the consumption and dilution of the blood sample are reduced, and the demand for blood samples is reduced, thereby achieving micro-sampling and priority sampling, which is suitable for the preparation of small sample volumes. Specifically, the sampling is open sampling, that is, the blood sample container 70 is open, and the sample loading mechanism directly draws the sample from the open part. Exemplarily, when the type of the blood sample container 70 is a micro-blood collection tube, the cover of the micro-blood collection tube is manually opened, and the sample loading mechanism directly draws the sample from the open part.

[0264] In the above embodiment, the sample loading mechanism can be moved toward the test tube inserted by the operator, and the blood sample can be directly sucked and loaded by the sample loading mechanism. Of course, the blood sample container 70 inserted by the operator can also be moved directly toward the sample loading mechanism, and the blood sample can be directly sucked and loaded by the sample loading mechanism.

[0265] It should be noted that the first sampling bit may be the same as the second sampling bit. Of course, the first sampling bit may also be different from the second sampling bit, and the embodiment of the present application is not limited thereto.

[0266] Please continue reading Figures 32 to 34 The sample loading mechanism of the sample loading device 20 drips the blood sample onto the glass slide, then performs a smear pushing operation. The smear pushing device 30 pushes the blood sample onto the glass slide into a blood film, thereby producing a smear. In some embodiments, after the smear pushing operation is completed, the blood film on the glass slide can be dried to stabilize its shape. After the smear is obtained, it can be stained by the staining device 40 or directly output (for example, placed in a slide basket 50 for output).

[0267] In some embodiments, the slide pusher further includes a scanning device 60 (see FIG. 17 ). The scanning device 60 is used to scan a barcode on a blood sample container 70 and determine the type of the blood sample container 70 based on the barcode. For example, if the scanning device 60 scans the barcode on the blood sample container 70 and determines the type of the blood sample container 70 based on the barcode, if the blood sample container 70 is determined to be a vacuum blood collection tube, the sampling mechanism draws the blood sample and then transports it to the sample loading mechanism, where the loading mechanism loads the blood sample. If the blood sample container 70 is determined to be a micro blood collection tube, the sample loading mechanism draws the blood sample and loads the blood sample.

[0268] Please refer to Figures 34 to 41 The sample loading device 20 of the embodiment of the present application includes a sampling needle 21, a blood dropping needle 22, a first driving mechanism 23, a second driving mechanism 24, a third driving mechanism 25, an air source mechanism 26 (see Figure 17) and a frame 27.

[0269] See also Figure 41 The sampling needle 21 is used to draw a blood sample 80. In some embodiments, the sampling needle 21 includes a main body 211 and a needle mouth 212 connected to one end of the main body 211. The main body 211 and the needle mouth 212 cooperate to form a reagent flow channel for drawing the blood sample 80. The reagent flow channel extends along the length of the main body 211, and one end is opened at the needle mouth 212. This opening is used to draw the blood sample 80 from the blood sample container 70. The needle mouth 212 is capable of puncturing the cover of the blood sample container 70, allowing the sampling needle 21 to pass through the cover of the blood sample container 70 and draw the blood sample 80. The needle mouth 212 can be designed in any suitable shape according to actual needs. For example, the needle mouth 212 extends in a gradually decreasing manner from one end facing the main body 211 to the end facing away from the main body 211. This needle mouth 212 structure effectively punctures the cover of the blood sample container 70 and enters the blood sample container 70 to draw the blood sample 80.

[0270] See also Figure 35 、 Figure 37 and Figure 39 The blood-dropping needle 22 and the sampling needle 21 form a fluid channel for drawing a blood sample 80 and loading the blood sample 80 onto a glass slide. Exemplarily, the blood-dropping needle 22 includes a needle body 221 and a needle head 222 connected to the needle body 221. In some embodiments, the blood in the blood sample container 70 can be drawn through the needle head 222 and loaded onto the glass slide through the needle head 222. Of course, in other embodiments, the sampling needle 21 can also draw a blood sample 80 from the blood sample container 70, and the blood sample 80 can be loaded onto the glass slide through the needle head 222. The needle body 221 and the needle head 222 cooperate to form a liquid flow channel extending along the length of the needle body 221.

[0271] The needle 222 can be designed into any suitable shape according to actual needs. For example, the needle port channel of the needle 222 extends along the length of the needle body 221 in a manner that is substantially the same in size. More specifically, the main channel of the needle body 221 is connected to the needle port channel to form a liquid flow channel. The liquid channel extends along the length of the blood drop needle 22 in a manner that is substantially the same in size. The needle 222 of this structure can effectively load the blood sample in the blood drop needle 22 onto the glass slide, preventing the blood sample from remaining in the liquid flow channel in the blood drop needle 22, reducing the consumption of the blood sample, and improving the utilization rate of the blood sample.

[0272] In some embodiments, the sample loading device 20 further includes a flexible tube (not shown). One end of the flexible tube is connected to the sampling needle 21, and the other end of the flexible tube is connected to the blood dropping needle 22. The sampling needle 21 is connected to the blood dropping needle 22 through the flexible tube to form a fluid channel for transporting the blood sample.

[0273] See also Figure 34 、 Figure 36 、 Figure 38 and Figure 40 The first drive mechanism 23 is used to drive the sampling needle 21 and the blood-dropping needle 22 to move back and forth simultaneously in the first direction. The first drive mechanism 23 is mounted on the frame 27 and is connected to the sampling needle 21 and the blood-dropping needle 22. The first drive mechanism 23 can drive the sampling needle 21 and the blood-dropping needle 22 to move back and forth simultaneously in the first direction.

[0274] See also Figure 33 、 Figure 36 、 Figure 38 and Figure 40 The second drive mechanism 24 is mounted on the first drive mechanism 23 and connected to the blood-dropping needle. The second drive mechanism 24 is capable of driving the blood-dropping needle 22 to reciprocate in the second direction. The third drive mechanism 25 is mounted on the first drive mechanism 23 and connected to the sampling needle 21, and is configured to drive the sampling needle 21 to reciprocate in the second direction. The air source mechanism 26 is mounted on the frame 27 and is configured to provide an air source to the sampling needle 21 and the blood-dropping needle 22.

[0275] It should be noted that the first direction is different from the second direction. For example, see Figure 34 、 Figure 36 、 Figure 38 and Figure 40 The first direction is the Y direction, and the second direction is the Z direction, with the first direction being substantially perpendicular to the second direction. In the figure, the X direction is the direction in which the slide loader 10a transports the slide 90. Of course, the first direction and the second direction may also be any other suitable directions, and the angle between the first direction and the second direction may also be any other suitable angle, and the embodiments of the present application are not limited thereto.

[0276] Please refer again Figure 40 and Figure 41 When the sampling needle 21 draws a blood sample and the blood-dropping needle 22 loads the blood sample, the first drive mechanism 23 and the third drive mechanism 25 drive the sampling needle 21 to the first sampling position. The air source mechanism 26 operates to cause the sampling needle 21 to draw the blood sample and transfer it to the blood-dropping needle 22. The first drive mechanism 23 and the second drive mechanism 24 drive the blood-dropping needle 22 to the sample loading position, where it loads the blood sample onto the slide. This method of aspirating and loading blood is suitable for preparing slides with large blood samples.

[0277] Please refer again Figures 34 to 39 When the blood-dropping needle 22 draws and loads the blood sample, the first drive mechanism 23 and the second drive mechanism 24 drive the blood-dropping needle 22 to the second sampling position. The air source mechanism 26 is activated to allow the blood-dropping needle 22 to draw the blood sample. The first drive mechanism 23 and the second drive mechanism 24 drive the blood-dropping needle 22 to move to the sample loading position, where the blood-dropping needle 22 loads the blood sample onto the glass slide. This method of drawing and loading the blood sample directly by the blood-dropping needle 22 draws and loads the blood sample, without the blood sample flowing to the blood-dropping needle 22 after the sampling needle 21 draws the blood sample. This reduces blood sample consumption and dilution, and reduces the demand for blood samples, thereby achieving micro-sampling and priority sampling, and is suitable for preparing slides with small amounts of blood samples.

[0278] The sampling needle 21, the blood dropping needle 22, the second drive mechanism 24 and the third drive mechanism 25 of the sample loading device 20 are all mounted on the first drive mechanism 23. The first drive mechanism 23 can drive the sampling needle 21 and the blood dropping needle 22 to move simultaneously in the first direction, eliminating the need for two independent first drive mechanisms, resulting in a simple structure. In addition, the sample loading device 20 can be used for both large and small blood sample preparation.

[0279] See also Figure 32 、 Figure 36 、 Figure 38 and Figure 40In some embodiments, the first driving mechanism 23 includes a first mounting plate 231, a first motor 232, and a conveying assembly 233. The first mounting plate 231 is mounted on the frame 27, and the first motor 232 is mounted on the first mounting plate 231. The conveying assembly 233 includes a driving wheel 2331, a driven wheel 2332, and a conveyor belt 2333. The driving wheel 2331 is located at one end of the first mounting plate 231, and is in transmission connection with the first motor 232. The driven wheel 2332 is located at the other end of the first mounting plate 231, and the conveyor belt 2333 is mounted on the driving wheel 2331 and the driven wheel 2332. The sampling needle 21, the blood dropping needle 22, the second driving mechanism 24, and the third driving mechanism 25 are mounted on the conveyor belt 2333.

[0280] Specifically, the first motor 232 can drive the driving wheel 2331 to rotate forward or reverse, so that the conveyor belt 2333 moves in the positive direction or negative direction of the first direction, thereby causing the sampling needle 21, the blood dropping needle 22, the second drive mechanism 24, and the third drive mechanism 25 on the conveyor belt 2333 to move back and forth in the first direction at the same time.

[0281] In one embodiment, the first drive mechanism 23 further includes a guide rod 234. The guide rod 234 extends along the first direction, with its ends connected to the ends of the first mounting plate 231. The guide rod 234 passes through the second mounting plate 241 of the second drive mechanism 24 and is used to provide guidance for the second mounting plate 241 of the second drive mechanism 24, thereby ensuring that the sampling needle 21 and the blood drop needle 22 mounted on the second mounting plate 241 can reciprocate along the first direction.

[0282] In other embodiments, the first driving mechanism 23 may be a screw-nut transmission structure or a gear transmission structure, etc., but the present application is not limited thereto.

[0283] See also Figure 34 、 Figure 36 、 Figure 38 、 Figure 40 、 Figure 42 and Figure 43 In some embodiments, the second driving mechanism 24 includes a second mounting plate 241 , a first screw assembly 242 , a first sliding assembly 243 , a second motor 244 and a first loading assembly 245 .

[0284] See also Figure 34 、 Figure 36 、 Figure 38 、 Figure 40 、 Figure 42The second mounting plate 241 is mounted on the conveyor belt 2333. One end of the first screw assembly 242 and the second motor 244 are both mounted on the second mounting plate 241, and the other end of the first screw assembly 242 is in driving connection with the second motor 244. In this way, the first screw assembly 242 and the second motor 244 can be fixed on the second mounting plate 241, and the second motor 244 can drive the first screw assembly 242 to operate.

[0285] Please refer again Figure 34 、 Figure 36 、 Figure 38 、 Figure 40 、 Figure 42 The first sliding assembly 243 includes a first slide rail 2431 and a first slider 2432. The first slide rail 2431 is mounted on the second mounting plate 241, and the first slider 2432 is slidably mounted on the first slide rail 2431. Specifically, the first slide rail 2431 extends along the second direction.

[0286] See also Figures 42 to 45 The first loading assembly 245 is mounted on the first slider 2432 and is connected to the first screw assembly 242. The blood drop needle 22 is mounted on the first loading assembly 245. The second motor 244 drives the first loading assembly 245 to reciprocate along the second direction through the first screw assembly 242.

[0287] See also Figure 44 and Figure 45 The first loading assembly 245 includes a mounting kit 2451, a blood drop needle mounting member 2452, and a first elastic member 2453. The mounting kit 2451 includes a first mounting block 24511 for mounting the blood drop needle 22 and a first connecting block 24512 connected to the first mounting block 24511. The first mounting block 24511 is mounted on the first slider 2432, and the first connecting block 24512 is connected to the first screw assembly 242.

[0288] See also Figure 45 In some embodiments, the first mounting block 24511 and the first connecting block 24512 are integrally formed. This ensures the reliability of the connection between the first mounting block 24511 and the first connecting block 24512. When the second motor 244 drives the first connecting block 24512 to reciprocate along the second direction via the first screw assembly 242, the first mounting block 24511 can move synchronously with the first connecting block 24512. Of course, in other embodiments, the first mounting block 24511 and the first connecting block 24512 can also be provided as separate bodies, and the two can be connected and fixed by adhesive or fasteners, etc., and the embodiments of the present application are not limited to this.

[0289] See also Figure 44 and Figure 45Specifically, the first connecting block 24512 defines a U-shaped groove 24513, with the opening of the U-shaped groove 24513 facing away from the first mounting block 24511. The lead screw 2421 of the first lead screw assembly 242 passes through the two side walls of the U-shaped groove 24513. One end of the lead screw 2421 is drivingly connected to the second motor 244, and the other end is fixed to the second mounting plate 241. The lead screw nut 2422 of the first lead screw assembly 242 is sleeved on the lead screw 2421 and is located in the U-shaped groove 24513. The lead screw 2421 is drivingly engaged with the first connecting block 24512 through the lead screw nut 2422.

[0290] See also Figures 43 to 45 The blood dropper mounting member 2452 is movably mounted on the first mounting block 24511. Specifically, the first mounting block 24511 defines a mounting hole 24514. The blood dropper mounting member 2452 includes a first column 24521 and a second column 24522 aligned with the first column 24521. The cross-sectional dimensions of the first column 24521 are greater than the cross-sectional dimensions of the second column 24522. The second column 24522 is movably mounted on the mounting hole 24514. In one embodiment, the centerlines of the first column 24521 and the second column 24522 coincide.

[0291] See also Figures 43 to 45 One end of the first elastic member 2453 abuts the blood-dropping needle mounting member 2452, and the other end abuts the mounting sleeve 2451. The blood-dropping needle 22 can flexibly pass through the blood-dropping needle mounting member 2452 and the first elastic member 2453. Specifically, one end of the first elastic member 2453 abuts the side of the first column 24521 facing the second column 24522, and the other end of the first elastic member 2453 abuts the first mounting block 24511. The first elastic member 2453 is sleeved onto the second column 24522, and the blood-dropping needle 22 can flexibly pass through the first column 24521 and the second column 24522. The provision of the first elastic member 2453 prevents the blood-dropping needle 22 from rigidly impacting the blood sample container 70 or the slide, thereby extending the service life of the blood-dropping needle 22. When the amount of blood sample is small, when the blood dropping needle 22 contacts the bottom of the blood sample container 70 to absorb the sample, the first elastic member 2453 can play a buffering role to prevent the blood dropping needle 22 from rigidly hitting the blood sample container 70, thereby ensuring that the blood dropping needle 22 is not damaged and the blood sample in the blood sample container 70 can be fully utilized.

[0292] Please refer to 44. Figure 45 and Figure 46In some embodiments, the mounting kit 2451 further includes abutment 24515 and a locking member 24516. The abutment 24515 is mounted on the mounting hole 24514, the blood drop needle mounting member 2452 can be movably passed through the abutment 24515, and the other end of the first elastic member 2453 abuts against the abutment 24515. Specifically, the abutment 24515 includes an exposed portion 24517, an abutment 24518, and a penetration portion 24519. The exposed portion 24517, the abutment 24518, and the penetration portion 24519 are connected in sequence. The cross-sectional dimension of the exposed portion 24517 is greater than the cross-sectional dimension of the abutment 24518, and the cross-sectional dimension of the exposed portion 24517 is greater than the aperture of the mounting hole 24514 to limit the abutment 24515. The cross-sectional dimension of the abutting portion 24518 is larger than the cross-sectional dimension of the penetrating portion 24519, so that the abutting portion 24518 and the penetrating portion 24519 cooperate to form a step, and the other end of the first elastic member 2453 can extend into the mounting hole 24514 and abut on the step.

[0293] See also Figure 44 and Figure 46 The exposed portion 24517 is located on the side of the first mounting block 24511 facing away from the first column 24521. The abutting portion 24518 and the penetrating portion 24519 penetrate the mounting hole 24514. The outer dimensions of the abutting portion 24518 match the mounting hole 24514, allowing the abutting portion 24518 to be located within the mounting hole 24514. The abutting member 24515 has a through hole that passes through the exposed portion 24517, the abutting portion 24518, and the penetrating portion 24519. The second column 24522 can movably penetrate the through hole.

[0294] Please refer to Figure 13 and Figure 14 The locking member 24516 is connected to the end of the blood dropper mounting member 2452 facing away from the needle 222. Specifically, the locking member 24516 extends through a through hole and connects to the end of the second column 24522 facing away from the first column 24521. The blood dropper 22 passes through the first column 24521, the second column 24522, and the locking member 24516. The various components of the first loading assembly 245 cooperate to secure the blood dropper 22 and provide a buffering effect in the second direction. In one embodiment, the locking member 24516 may be a locking structure such as a bolt or a snap ring.

[0295] In some embodiments, the first elastic member 2453 is a coil spring, and the elastic extension direction of the first elastic member 2453 is the same as the extension direction of the blood dropping needle 22 .

[0296] See also Figures 34 to 42In some embodiments, the needle 222 has a first flow channel, and the first loading assembly 245 includes a second mounting block (not shown), a second connecting block (not shown), and a second elastic member (not shown). The second mounting block is mounted on the first slider 2432, and the blood dropper 22 is mounted on the second mounting block. Specifically, the blood dropper 22 can be mounted on the second mounting block via a threaded connection structure. Of course, the blood dropper 22 can be mounted on the second mounting block via a structure such as a clasp, but the embodiments of the present application are not limited thereto.

[0297] The second connecting block is connected to the second mounting block and to the first screw assembly 242. In some embodiments, the second mounting block and the second connecting block are integrally formed, which can ensure the reliability of the connection between the second mounting block and the second connecting block. When the second motor 244 drives the second connecting block to move back and forth in the second direction through the first screw assembly 242, the second mounting block can move synchronously with the second connecting block. Of course, in other embodiments, the second mounting block and the second connecting block can also be provided separately, and the two can be connected and fixed by adhesive or fasteners, etc., and the embodiments of the present application are not limited to this.

[0298] A second elastic member is mounted on the needle head 222 and defines a second flow channel connected to the first flow channel. The provision of the second elastic member prevents the blood dropper 22 from rigidly impacting the blood sample container 70 or a slide, thereby extending the service life of the blood dropper 22. When the amount of blood sample is small, the second elastic member acts as a buffer when the blood dropper 22 contacts the bottom of the blood sample container 70 for sample aspiration, preventing the blood dropper 22 from rigidly impacting the blood sample container 70. This protects the blood dropper 22 from damage while fully utilizing the blood sample in the blood sample container 70.

[0299] Please refer to the figure Figure 34 、 Figure 36 、 Figure 38 、 Figure 40 、 Figure 42 and Figure 47 In some embodiments, the third driving mechanism 25 includes a second screw assembly 251 , a second sliding assembly 252 , a third motor 253 and a second loading assembly 254 .

[0300] One end of the second lead screw assembly 251 is mounted on the second mounting plate 241. The second sliding assembly 252 includes a second slide rail 2521 and a second slider 2522. The second slide rail 2521 is mounted on the second mounting plate 241, and the second slider 2522 is slidably mounted on the second slide rail 2521. The third motor 253 is mounted on the second mounting plate 241 and is in driving connection with the other end of the second lead screw assembly 251. The second loading assembly 254 is mounted on the second slider 2522. The second loading assembly 254 is connected to the second lead screw assembly 251, and the sampling needle 21 is mounted on the second loading assembly 254.

[0301] The third motor 253 is connected to the second loading assembly 254 via the second screw assembly 251 , thereby driving the second loading assembly 254 to reciprocate along the second direction, and the sampling needle 21 mounted on the second loading assembly 254 also reciprocates along the second direction.

[0302] 16 , in some embodiments, the second loading assembly 254 includes a loading block 2541 and a mating block 2542. The loading block 2541 is mounted on the second slider 2522, and the sampling needle 21 is mounted on the loading block 2541. The mating block 2542 is connected to the loading block 2541, and the mating block 2542 is connected to the second lead screw assembly 251.

[0303] In some embodiments, the loading block 2541 and the mating block 2542 are integrally formed, which ensures the reliability of the connection between the loading block 2541 and the mating block 2542. When the second motor 244 drives the mating block 2542 to reciprocate along the second direction via the first screw assembly 242, the loading block 2541 can move synchronously with the mating block 2542. Of course, in other embodiments, the loading block 2541 and the mating block 2542 can also be provided as separate bodies, and the two can be connected and fixed by adhesive or fasteners, etc., and the embodiments of the present application are not limited to this.

[0304] Please refer again Figure 34 、 Figure 36 、 Figure 38 、 Figure 40 、 Figure 42 In some embodiments, the sample loading device 20 further includes a first swab 281 and a second swab 282 .

[0305] The blood-dropping needle 22 passes through the first swab 281 and can move relative to the first swab 281 in the second direction so that the first swab 281 can clean the outer wall of the blood-dropping needle 22. The first swab 281 that passes through the liquid can clean the outer wall of the blood-dropping needle 22 to prevent contamination. Specifically, the first swab 281 can move axially relative to the blood-dropping needle 22 to clean the outer wall of the blood-dropping needle 22. In some specific embodiments, the outer wall of the blood-dropping needle 22 can be automatically cleaned by the first swab 281, thereby cleaning the blood sample remaining on the outer wall of the blood-dropping needle 22, without the need to wipe it with a paper towel, reducing biological risks and the probability of clogging.

[0306] The sampling needle 21 passes through the second swab 282 and is movable relative to the second swab 282 in a second direction so that the second swab 282 cleans the outer wall of the sampling needle. The second swab 282, which is permeable to liquid, can clean the outer wall of the sampling needle 21 to prevent contamination. Specifically, the second swab 282 can move axially relative to the sampling needle 21 to clean the outer wall of the sampling needle 21. In some specific embodiments, the outer wall of the sampling needle 21 can be automatically cleaned by the second swab 282, thereby cleaning the blood sample remaining on the outer wall of the sampling needle 21, without the need for wiping with a paper towel, thereby reducing biological risks and the probability of clogging.

[0307] See also Figure 38 The sample loading device 20 further includes a control mechanism 29. The air source mechanism 26, the first drive mechanism 23, the second drive mechanism 24, and the third drive mechanism 25 are all electrically connected to the control mechanism 29, so that the control mechanism 29 controls the air source mechanism 26, the first drive mechanism 23, the second drive mechanism 24, and the third drive mechanism 25 to operate, so that the blood drop needle 22 draws a blood sample and loads the blood sample onto a glass slide, or the sampling needle 21 draws a blood sample and transfers the blood sample to the blood drop needle 22 to load the blood sample onto a glass slide.

[0308] It can be understood that the control mechanism 29 is also electrically connected to the slide loading device 10a, the slide pushing device 30, the staining device 40 and the scanning device 60 to control the operation of the slide loading device 10a, the slide pushing device 30, the staining device 40 and the scanning device 60.

[0309] See also Figure 34 、 Figure 36 、 Figure 38 、 Figure 40 and Figure 48 In some embodiments, the sample loading device 20 further includes a sample injection mechanism 283 electrically connected to the control mechanism 29. Specifically, the sample collection mode includes a manual sample collection mode and an automatic sample collection mode, and the control mechanism 29 can control the sample loading device 20 to switch between the manual sample collection mode and the automatic sample collection mode. When the sample collection mode is switched to the automatic sample collection mode, the sample injection mechanism 283 of the control mechanism 29 transports the blood sample container 70 to the first sampling position or the second sampling position, so that the sampling needle 21 or the blood drop needle 22 can absorb the blood sample 80 at the corresponding sampling position for making a smear.

[0310] See also Figure 34 and Figure 35In this embodiment, the blood sample container 70 is a vacuum blood collection tube. When the sample collection mode is switched to the manual sample collection mode, the first drive mechanism 23 drives the second drive mechanism 24 and the third drive mechanism 25 to move simultaneously in the first direction, so that the blood dropper 22 moves to the manual collection position. Then, driven by the second drive mechanism 24, the blood dropper 22 moves in the second direction, so that the blood dropper 22 extends to a position visible to the operator. At this time, the operator usually manually opens or removes the cover of the vacuum blood collection tube so that the blood dropper 22 is immersed in the blood sample 80 in the open vacuum blood collection tube. The control mechanism 29 controls the operation of the air source mechanism 26 so that the blood dropper 22 draws the blood sample 80 from the vacuum blood collection tube.

[0311] See also Figure 36 and Figure 37 In this embodiment, the blood sample container 70 is a micro-sampling tube. When the sample collection mode is switched to manual sampling mode, the control mechanism 29 controls the first drive mechanism 23 to drive the second drive mechanism 24 and the third drive mechanism 25 simultaneously in the first direction, moving the blood dropper 22 to the manual collection position. The second drive mechanism 24 then drives the blood dropper 22 in the second direction, extending it to a position visible to the operator. At this point, the operator typically manually opens or removes the lid of the micro-sampling tube to immerse the blood dropper 22 in the blood sample 80 within the open micro-sampling tube. The control mechanism 29 controls the air source mechanism 26 to operate, allowing the blood dropper 22 to aspirate the blood sample 80 from the micro-sampling tube. Because the amount of blood sample 80 in a micro-sampling tube is generally small, the bottom of the blood dropper 22 typically needs to contact the bottom of the tube when aspirating the blood sample 80 to ensure full utilization of the blood sample within the tube.

[0312] See also Figure 38 and Figure 39In this embodiment, the blood sample container 70 is a micro-sampling tube, and the operator manually opens the lid of the micro-sampling tube. When the sample collection mode is switched to automatic sample collection mode, the control mechanism 29 controls the sample feed mechanism 283 to transport the blood sample container 70 to the automatic collection position. The scanning device 60 scans the barcode on the blood sample container 70 and determines whether the blood sample container 70 is a micro-sampling tube based on the barcode. If the blood sample container 70 is a micro-sampling tube, the control mechanism 29 controls the first drive mechanism 23 to drive the second drive mechanism 24 and the third drive mechanism 25 simultaneously in the first direction, causing the blood droplet needle 22 to move to the automatic collection position. Then, driven by the second drive mechanism 24, the blood droplet needle 22 moves in the second direction, extending and inserting into the micro-sampling tube, so that the blood droplet needle 22 is immersed in the blood sample 80 in the open micro-sampling tube. The control mechanism 29 controls the air supply mechanism 26 to operate, causing the blood droplet needle 22 to aspirate the blood sample 80 from the micro-sampling tube. Since the blood sample 80 in the micro-blood collection tube is generally small, when the blood dropping needle 22 draws the blood sample 80 from the micro-blood collection tube, the bottom of the blood dropping needle 22 usually needs to contact the bottom of the micro-blood collection tube to ensure full utilization of the blood sample in the micro-blood collection tube.

[0313] See also Figure 40 and Figure 41 In this embodiment, the blood sample container 70 is a vacuum blood collection tube, which is typically kept in a closed lid. When the sample collection mode is switched to automatic, the control mechanism 29 controls the sample feed mechanism 283 to transport the blood sample container 70 to the automatic collection position. The scanning device 60 scans the barcode on the blood sample container 70 and determines whether it is a vacuum blood collection tube based on the barcode. If the blood sample container 70 is a vacuum blood collection tube, the control mechanism 29 controls the first drive mechanism 23 to simultaneously drive the second drive mechanism 24 and the third drive mechanism 25 in a first direction, causing the sampling needle 21 to move to the automatic collection position. Driven by the third drive mechanism 25, the sampling needle 21 then moves in a second direction, extending and piercing the lid of the vacuum blood collection tube into the tube, immersing the sampling needle 21 in the blood sample 80 within the tube. The control mechanism 29 controls the air supply mechanism 26 to operate, causing the sampling needle 21 to aspirate the blood sample 80 from the tube.

[0314] It is understandable that the manual sampling position and the automatic sampling position can be the same or different. The manual sampling position and the automatic sampling position can be the same as the first sampling position or the second sampling position, or they can be different. The embodiment of the present application is not limited thereto.

[0315] See also Figure 42The blood-dropping needle 22 is in the sample loading position and drips the blood sample onto the glass slide 90. The control mechanism 29 controls the slide loading device 10a to transport the glass slide 90 to the sample loading position. The control mechanism 29 controls the first drive mechanism 23 to drive the second drive mechanism 24 and the third drive mechanism 25 to move simultaneously in the first direction. The second drive mechanism 24 drives the blood-dropping needle 22 in the second direction, so that the blood-dropping needle 22 moves to the sample loading position. The second drive mechanism 24 drives the blood-dropping needle 22 in the second direction until the bottom of the blood-dropping needle 22 contacts the top surface of the glass slide 90. The control mechanism 29 controls the air source mechanism 26 to operate, causing the blood sample 80 in the blood-dropping needle 22 to drip onto the glass slide 90.

[0316] Understandably, Figures 1 to 30 The specific structure of the first driving part 1021 in the sample loading device shown in FIG. Figures 32 to 48 The structure of the first driving mechanism 23 in the sample loading device is shown and will not be described in detail here.

[0317] It can be understood that the blood-dropping needle can be understood as a sample adding needle.

[0318] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in the present invention, and such modifications or substitutions are intended to be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of protection of the claims.

[0319] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A sample loading device for a slide pusher, characterized in that: include: A frame, wherein the frame is provided with an operating position; A driving mechanism, which is mounted on the frame and connected to the sampling needle and the blood dropping needle, and is used to drive the sampling needle and / or the blood dropping needle to move to the operating position for operation; The central axes of the sampling needle and the blood-dropping needle are parallel to the vertical direction, so that the sampling needle and the blood-dropping needle can perform vertical operations along the vertical direction; the operation of the sampling needle includes sucking the blood sample from the container on the operation position, the blood-dropping needle and the sampling needle form a fluid channel, and the operation of the blood-dropping needle includes sucking the blood sample and / or loading the blood sample onto the glass slide at the operation position; The driving mechanism comprises a first driving part and a second driving part, wherein the first driving part is used to change the positions of the sampling needle and the blood dropping needle in a first direction; the sampling needle and the blood dropping needle are both arranged on the second driving part, and under the drive of the second driving part, the sampling needle and the blood dropping needle are simultaneously moved along the second direction to drive the sampling needle and / or the blood dropping needle to move to the operating position, the second direction being a vertical direction, and the first direction and the second direction are different; The operating position includes an automatic whole blood sampling position, a blood dropping position and a micro sampling position, and the micro sampling position and the automatic whole blood sampling position are both the first position of the frame; under the drive of the first driving part and the second driving part, the sampling needle and / or the blood dropping needle can be moved along the first direction and the second direction to the operating position of the first position to perform operation; the operation of the sampling needle includes puncturing and aspirating a first blood sample from a first container located on the automatic whole blood sampling position, the first blood sample aspirated by the sampling needle flows to the blood dropping needle through the fluid channel, and the operation of the blood dropping needle includes transferring the first blood sample aspirated by the sampling needle to the first blood sample loaded onto the glass slide located at the blood dripping position; the operation of one of the sampling needle and the blood dripping needle also includes being used to absorb the second blood sample from the second container located at the micro-sampling position, and the operation of the blood dripping needle also includes loading the second blood sample in the blood dripping needle onto the glass slide located at the blood dripping position; wherein, the first container carrying the first blood sample and the second container carrying the second blood sample can be moved to the first position in a direction close to the first position, the first container located at the automatic whole blood sampling position is a vacuum container moved to the first position, and the second container located at the micro-sampling position is an open container moved to the first position.

2. The sample loading device according to claim 1, characterized in that: The first driving part is mounted on the frame, and the second driving part is mounted on the first driving part. The first driving part is used to drive the second driving part to move so as to change the position of the second driving part in a first direction. The sampling needle and the blood dropping needle are separated by a fixed distance.

3. The sample loading device according to claim 1, characterized in that: The rack is further provided with an avoidance position. When one of the sampling needle and the blood dropping needle descends to the operating position to perform an operation, the other is located in the avoidance position.

4. The sample loading device according to claim 1, characterized in that: The automatic whole blood sampling position and the blood dropping position are located inside the frame.

5. The sample loading device according to claim 3, characterized in that: The sample loading device further comprises a cleaning component, which is used to clean the blood dropping needle.

6. The sample loading device according to claim 5, characterized in that: The cleaning component includes a cleaning container and a reaction liquid stored in the cleaning container. The operation position also includes a cleaning position, and the cleaning position is provided with the cleaning container. The operation of the blood drop needle also includes moving it to the cleaning container of the cleaning position for cleaning.

7. The sample loading device according to claim 6, characterized in that: The blood dropping position is located between the cleaning position and the automatic whole blood sampling position.

8. The sample loading device according to claim 6, characterized in that: The cleaning position is located between the automatic whole blood sampling position and the blood dropping position.

9. The sample loading device according to claim 5, characterized in that: The cleaning component comprises a first swab, the blood-dropping needle passes through the first swab and can move relative to the first swab along the second direction, so that the first swab cleans the outer wall of the blood-dropping needle.

10. The sample loading device according to claim 1, characterized in that: The micro sampling position is located inside the frame.

11. The sample loading device according to claim 3, characterized in that: The operation of the blood dropping needle further includes sucking a second blood sample from a second container located on the micro-sampling position, so that the blood dropping needle can load the second blood sample onto the glass slide on the blood dropping position.

12. The sample loading device according to claim 11, characterized in that: The sample loading device further includes a sample rack, on which a plurality of sample seats are provided. The sample seats are used to accommodate the first container and the second container and can move in a direction close to the first position.

13. The sample loading device according to claim 12, characterized in that: The sample loading device also includes an identification component and a controller. The identification component is used to identify the type of the container at the first position and send a type signal to the controller. The controller controls the sampling needle or the blood dropper to absorb the blood sample from the container at the first position according to the type signal.

14. The sample loading device according to claim 13, characterized in that: The identification component includes a scanning module and a label provided on the container. The scanning module is used to scan the label on the container and send a type signal to the controller. The controller determines the type of the container based on the type signal and controls the sampling needle or the blood dropper to absorb the blood sample from the container at the first position.

15. The sample loading device according to claim 13, characterized in that: The bottom wall of the second container has a recess, and the identification component includes a probe provided on the sample seat, the probe is used to detect the structure of the bottom wall of the container at the first position and send a type signal to the controller. The controller determines the type of the container according to the type signal and controls the sampling needle or the blood dropper to absorb the blood sample from the container at the first position.

16. The sample loading device according to claim 11, characterized in that: When the blood-dropping needle draws the blood sample from the second container located on the micro-sampling position, the sampling needle is located at the space-avoiding position close to the blood-dropping position.

17. The sample loading device according to claim 3, characterized in that: The operation position also includes a manual sampling position, which is provided with a manually placed third container. The operation of one of the sampling needle and the blood dropping needle also includes drawing a third blood sample from the third container located on the manual sampling position. The operation of the blood dropping needle also includes loading the third blood sample in the blood dropping needle onto a glass slide located at the blood dropping position.

18. The sample loading device according to claim 17, characterized in that: The operation of the sampling needle also includes drawing a third blood sample from a third container located on the manual sampling position. The blood sample drawn by the sampling needle flows to the blood dropping needle through the fluid channel. The operation of the blood dropping needle also includes loading the blood sample drawn by the sampling needle onto a glass slide located on the blood dropping position.

19. The sample loading device according to claim 18, characterized in that: The automatic whole blood sampling position is located between the manual sampling position and the blood dropping position. When the sampling needle is used to absorb the third blood sample from the third container located on the manual sampling position, the blood dropping needle is located in the avoidance position close to the automatic whole blood sampling position.

20. The sample loading device according to claim 19, characterized in that: When the sampling needle is used to absorb the third blood sample from the third container located on the manual sampling position, the blood dropping needle is located at a space-avoiding position between the manual sampling position and the automatic whole blood sampling position.

21. The sample loading device according to claim 19, characterized in that: When the sampling needle draws the third blood sample from the third container located on the manual sampling position, the blood dropping needle is located at a space-avoiding position between the automatic whole blood sampling position and the blood dropping position.

22. The sample loading device according to claim 3, characterized in that: When the sampling needle absorbs the first blood sample from the first container located on the automatic whole blood sampling position, the blood dropping needle is located at a space-avoiding position between the automatic whole blood sampling position and the manual sampling position.

23. The sample loading device according to claim 17, characterized in that: The operation of the blood dropping needle further includes sucking a third blood sample from a third container located on the manual sampling position, and moving the blood dropping needle to load the third blood sample onto a glass slide on the blood dropping position.

24. The sample loading device according to claim 23, characterized in that: The automatic whole blood sampling position is located between the manual sampling position and the blood dropping position. When the blood dropping needle draws a blood sample from a third container located on the manual sampling position, the sampling needle is located at the avoidance position and is closer to the automatic whole blood sampling position than the blood dropping needle.

25. The sample loading device according to claim 17, characterized in that: The manual sampling position is located outside the frame, and the frame has a through hole connecting the outside of the frame and the inside of the frame. When one of the sampling needle and the blood dropping needle is used to absorb the third blood sample from the third container located on the manual sampling position, one of the sampling needle and the blood dropping needle extends to the outside of the frame through the through hole of the frame.

26. The sample loading device according to any one of claims 2 to 25, characterized in that: The first driving part is used to drive the second driving part to slide along the first direction, and the working position is arranged along the sliding track of the second driving part, so that the sampling needle or the blood dropping needle can be aligned with the working position.

27. The sample loading device according to claim 26, characterized in that: The second driving unit includes: a second mounting plate, mounted on the first driving part; a screw rod assembly, one end of which is mounted on the second mounting plate; A sliding assembly includes a slide rail and a slider, wherein the slide rail is mounted on the mounting plate, and the slider is slidably mounted on the slide rail; A second motor is mounted on the second mounting plate and is transmission-connected to the other end of the screw assembly; The loading assembly is installed on the sliding block and connected to the screw assembly. The sampling needle and the blood dropping needle are installed on the loading assembly.

28. The sample loading device according to any one of claims 2 to 25, characterized in that: The first driving part is used to drive the second driving part to rotate around a first rotation axis, and the working position is arranged along the rotation trajectory of the second driving part so that the sampling needle or the blood dropping needle can be aligned with the working position, wherein the first rotation axis is parallel to the second direction.

29. The sample loading device according to claim 28, characterized in that: A line connecting the sampling needle and the rotation center of the second driving part coincides with a line connecting the blood dropping needle and the rotation center of the second driving part.

30. The sample loading device according to claim 28, characterized in that A line connecting the sampling needle and the rotation center of the second driving part and a line connecting the blood dropping needle and the rotation center of the second driving part have a first preset angle.

31. The sample loading device according to claim 1, characterized in that: The driving mechanism comprises: a first driving mechanism, mounted on the frame, connected to the sampling needle and the blood dropping needle, and configured to drive the sampling needle and the blood dropping needle to move back and forth simultaneously in a first direction; a second driving mechanism, mounted on the first driving mechanism and connected to the blood-dropping needle, for driving the blood-dropping needle to reciprocate along a second direction, wherein the first direction is different from the second direction; The third driving mechanism is installed on the first driving mechanism, connected to the sampling needle, and is used to drive the sampling needle to move back and forth along the second direction.

32. The sample loading device according to claim 31, characterized in that The first driving mechanism comprises: A first mounting plate, mounted on the frame; a first motor, mounted on the first mounting plate; The transmission assembly includes a driving wheel, a driven wheel and a conveyor belt. The driving wheel is located at one end of the first mounting plate and is connected to the first motor. The driven wheel is located at the other end of the first mounting plate. The conveyor belt is installed on the driving wheel and the driven wheel. The second drive mechanism is installed on the conveyor belt.

33. The sample loading device according to claim 32, characterized in that: The second driving mechanism comprises: a second mounting plate, mounted on the conveyor belt; a first screw assembly, one end of which is mounted on the second mounting plate; A first sliding assembly includes a first slide rail and a first slider, wherein the first slide rail is mounted on the second mounting plate, and the first slider is slidably mounted on the first slide rail; a second motor, mounted on the second mounting plate and drivingly connected to the other end of the first screw assembly; The first loading assembly is installed on the first sliding block and is connected to the first screw assembly. The blood dropping needle is installed on the first loading assembly.

34. A film pusher, characterized in that: include: a slide loading device, for loading slides; The sample loading device according to any one of claims 1 to 33, wherein the blood-dropping needle of the sample loading device is used to draw a blood sample and load the blood sample onto the glass slide; or the sampling needle of the sample loading device is used to draw a blood sample and form a fluid channel for supplying the blood sample with the blood-dropping needle, so that the blood-dropping needle loads the blood sample onto the glass slide; a slide pushing device for smoothing the blood sample on the slide to form a smear; A staining device is used for staining the smear.

35. A sample loading method, applied to the slide pusher according to claim 34, characterized in that: The film pusher includes a sampling needle and a blood dropping needle, wherein the automatic whole blood sampling position and the micro-sampling position in the film pusher are located at the same preset position, and the method includes: Identifying an operation mode corresponding to the preset position, wherein the operation mode includes an automatic whole blood sampling mode and a micro sampling mode; According to the operation mode, the sampling needle or the blood dropper is controlled to vertically absorb the blood sample from the container at the preset position.

36. The sample loading method according to claim 35, wherein: “Controlling the sampling needle or the blood dropper to vertically draw the blood sample from the container at the preset position according to the operation mode” includes: If it is determined that the operation mode at the preset position is the automatic whole blood sampling mode, controlling the sampling to absorb the blood sample from the container at the preset position; If it is determined that the operation mode at the preset position is the micro-sampling mode, the blood dropper is controlled to absorb the blood sample from the container at the preset position.

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