An in vitro simulation device for vascular interventional embolization therapy

Abstract

The present invention belongs to the technical field of medical testing equipment, and specifically is an in vitro simulation device for vascular interventional embolization treatment. The device of the present invention includes a pulsating pump, an organ artery module, a basic blood vessel module, and a support structure; the pulsating pump is used to simulate the pulsating blood supply of the heart; the organ artery module includes a renal artery module, a hepatic artery module, and a splenic artery module, which are respectively used to simulate renal artery embolization, hepatic artery embolization, and splenic artery embolization; the basic blood vessel module is used to simulate the basic blood vessel pathway for the interventional catheter to enter the body; the support structure is used to support and fix each module and maintain the shape of the blood vessel. The device of the present invention has a high degree of blood vessel restoration, can be modified according to specific conditions, is transparent and visualized, and can more accurately simulate the embolism site and embolism process.

Description

Technical Field

[0001] The invention belongs to the technical field of medical testing instruments, and in particular relates to an in vitro simulation device for vascular interventional embolization treatment. Background Art

[0002] Vascular interventional embolization has been widely used in the treatment of internal bleeding, tumor treatment, surgical resection and other fields. This technology uses a catheter to deliver embolic agents to block blood flow in the target blood vessel, and the entire process is completed through real-time imaging guidance. The key to the embolization process is whether the embolic agent is accurately and appropriately injected into the target blood vessel. Therefore, doctors need to slowly complete the injection of embolic agents under X-ray fluoroscopy. This process takes up most of the time of the operation and will also cause a lot of radiation damage to interventional physicians, which cannot be completely avoided even if they wear lead suits. Reducing radiation damage is an urgent need for interventional physicians. In addition, there are no specific physiological parameters used as a standard for determining the degree of intraoperative embolization during the operation. The Chinese Clinical TACE Practice Guidelines for Hepatocellular Carcinoma point out that the embolization endpoint depends on angiography to observe whether the embolic material is completely stopped, the blood flow status of the supplying artery, and the imaging status of the lesion. This requires rich clinical experience to complete a more accurate judgment. The high difficulty of the operation and the requirement for doctors' relevant surgical experience make this effective treatment method difficult to popularize in grassroots hospitals.

[0003] On the one hand, doctors can shorten the time of each operation by increasing their surgical experience through continuous practice, but interventional surgery is difficult to operate and has a long learning cycle. Many medical staff find it difficult to get enough operation opportunities during their training and learning. On the other hand, using robotic technology to assist or replace doctors in completing the embolic injection process can effectively shorten the time doctors are exposed to radiation, but there are no reports on the market that can assist doctors in completing or independently completing embolic injections. Therefore, whether it is to help interventional physicians become familiar with the surgical process, accumulate operational experience, or to assist in the design and verification of the reliability and safety of the embolic injection robot system, an in vitro simulation device for vascular interventional embolization is needed.

[0004] Chinese utility model patent CN 209486948 U proposes a fully simulated vascular intervention simulation system. Although it has the main arteriovenous conduits to complete the human body's blood circulation, it lacks the expression of blood vessels in various organs, and the embolism site and embolism process cannot be simulated. Chinese utility model patent CN 210443088 U proposes a simulated embolization device, but its structure does not replicate the shape and condition of real blood vessels. Chinese utility model patent CN 207718689 U proposes an in vitro interventional embolization treatment simulation system, which simulates tiny blood vessels through a microfluidic chip to express the embolism situation, but the chip production cost is high, and the degree of blood vessel restoration is not high. It is mainly used for performance testing of embolic agents. Chinese invention patent CN111816043A proposes a vascular interventional surgery simulator. Although it reproduces the shape and shape of real blood vessels relatively completely, it only contains information about major blood vessels with larger diameters. For interventional embolization surgery, embolism mainly occurs in the capillaries of the diseased organs. Therefore, it can only simulate the process of the guidewire catheter entering the body, and it is difficult to simulate the embolization process. Summary of the invention

[0005] In response to the urgent demand of current interventional physicians and scientific researchers in related fields for an in vitro simulation device for vascular interventional embolization therapy, the present invention provides an in vitro simulation device for vascular interventional embolization therapy.

[0006] The in vitro simulation device for vascular interventional embolization treatment provided by the present invention comprises: a pulsating pump, an organ artery module, a basic blood vessel module, and a supporting structure; wherein:

[0007] The pulsating pump is used to simulate the pulsating blood supply of the heart;

[0008] The organ artery module is used to simulate the arterial blood vessels at the embolism site and the local capillary network of the organ where the embolism occurs;

[0009] The basic blood vessel module is used to simulate the basic blood vessel pathway for the interventional catheter to enter the body;

[0010] The support structure is used to support and fix each module to maintain the shape of the blood vessel;

[0011] The support structure is divided into two layers, the upper layer includes a blood pumping area for placing a pulsating pump, an embolism simulation area for placing basic blood vessel modules and organ artery modules, and a reflux area for placing terminal reflux pipelines; the lower layer is a blood storage tank as a whole; the upper and lower layers are separated by a common middle partition.

[0012] Furthermore, a drain port is provided at the bottom of the blood storage tank for releasing the liquid in the tank to the outside, and a plugging head connected by a thread is provided at the drain port for plugging and opening the drain port;

[0013] The blood pumping area is connected to the blood storage tank through a liquid inlet tube, one end of which is connected to the input end of the pulsating pump, and the other end of the liquid inlet tube is close to the bottom of the blood storage tank, which is a channel for the liquid in the tank to enter the pulsating pump;

[0014] Furthermore, the middle partition of the blood pumping area is provided with two holes, one of which is a through hole for passing the liquid inlet tube, and the other is a threaded hole for the liquid injection port, which has a plugging head connected by threads for plugging and opening the liquid injection port;

[0015] A pulsating pump is placed in the blood pumping area, and an output end of the pulsating pump is connected to the thoracic aorta orifice of the basic vascular module;

[0016] A plurality of hollow reflux support columns are installed on the middle partition of the embolism simulation area through threaded connection to support the organ artery module and introduce the liquid passing through the organ artery module into the blood storage tank through the hollow cavity;

[0017] There are two hollow reflux support columns on the middle partition of the reflux zone, which are connected to the middle partition through threaded connection and connected to the left and right external arteries on the basic vascular module for liquid reflux to the blood storage tank.

[0018] The basic vascular module is used to simulate the basic vascular pathway for interventional catheters to enter the body, including bilateral femoral arteries, abdominal aorta, thoracic aorta, bilateral renal artery branches, hepatic artery branches, and splenic artery branches; the bilateral femoral arteries are provided with puncture branches, which are the locations for microcatheter intervention for injecting embolic drugs; the ends of the bilateral renal artery branches, hepatic artery branches, and splenic artery branches can be connected to the organ artery module through a Luer connector, and can also be blocked by a Luer connector where the organ artery module is not installed.

[0019] The organ artery modules mainly include a renal artery module, a hepatic artery module and a splenic artery module, which are used to simulate renal artery embolization, hepatic artery embolization and splenic artery embolization; the organ shell of each organ artery module is made of transparent hard plastic and is a half-section model, which is used to show the organ shape and fix and support the blood vessels in the organ through a number of internal organ support columns; the lower part of the internal organ support column is connected to the organ shell by a threaded connection, and the upper part is a semi-cylindrical support body, which is used to support the blood vessels in the organ and the embolism simulation cylinder.

[0020] Furthermore, the bottom of the half-sectioned organ shell model has three organ shell openings for passing the return pipeline in the organ; the blood vessels in each organ artery module include the organ aorta and the main branches under the aorta, and the end of each branch is connected to an embolism simulation cylinder.

[0021] Furthermore, the embolism simulation cylinder includes a connecting sleeve, an initial end of an intra-organ reflux pipeline, an end of an organ artery branch and a filter sponge. One end of the connecting sleeve has a thread and is threadedly connected to the initial end of the intra-organ reflux pipeline. The other end is a double-layer tower structure and is connected to the end of the organ artery branch by plugging and unplugging.

[0022] Furthermore, the filter sponge is normally in the shape of a truncated cone and is squeezed into the connecting sleeve. Therefore, the mesh structure of the filter sponge in the sleeve changes from large to small in the direction of blood flow, which is used to simulate the characteristics of the blood vessels of the organs becoming smaller and smaller. When the embolic agent and blood flow through the cylinder, the embolic agent particles will be intercepted by the filter sponge and accumulated until they are completely blocked, which is consistent with the principle of embolization treatment. The filter sponge can be replaced with different specifications according to actual conditions.

[0023] In the present invention, the blood vessels of the organ artery module can be 3D printed through the patient's imaging data and the blood vessel reconstruction by commercial software, and the material is highly transparent soft silicone. Therefore, the real blood vessel shape and blood vessel state can be well reproduced, and can be modified according to the specific condition.

[0024] The in vitro simulation device for vascular interventional embolization treatment of the present invention has the following characteristics: high degree of vascular restoration, can be modified according to specific conditions, is transparent and visualized, and can more accurately simulate the embolism site and embolism process. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the structure of the in vitro simulation device for vascular interventional embolization treatment of the present invention.

[0026] Figure 2 It is a diagrammatic illustration of the basic vascular module structure in the present invention.

[0027] Figure 3 It is a schematic diagram of the renal artery module structure in the present invention.

[0028] Figure 4 It is a schematic diagram of the hepatic artery module structure in the present invention.

[0029] Figure 5 It is a schematic diagram of the splenic artery module structure in the present invention.

[0030] Figure 6 This is a diagram showing the interior and connections of the embolism simulation cylinder in the present invention.

[0031] Figure 7 It is a schematic diagram of the hollow cavity reflux support column structure of the present invention.

[0032] Numbers in the figure:

[0033] 1 is a pulsating pump, 1-1 is an output end of the pulsating pump, and 1-2 is an input end of the pulsating pump;

[0034] 2 is a supporting structure, 2-1 is a blood pumping area, 2-2 is an embolism simulation area, 2-3 is a reflux area, 2-4 is a middle partition, 2-5 is a liquid inlet pipe, 2-6 is a liquid discharge port plugging head, 2-7 is a liquid injection port plugging head, 2-8 is blood (blood-like), 2-9 is a blood storage tank, 2-10 is a cavity reflux support column, and 2-10-1 is a support column reflux hole;

[0035] 3 is the basic vascular module, 3-1 is the thoracic aorta, 3-2 is the celiac artery, 3-3 is the splenic artery, 3-4 is the hepatic artery, 3-5 is the renal artery, 3-6 is the abdominal aorta, 3-7 is the interventional puncture branch, 3-8 is the femoral artery, and 3-9 is other artery resistance modules;

[0036] 4 is an organ artery module, 4-1 is a liver artery module, 4-1-1 is a liver shell, 4-2 is a kidney artery module, 4-3 is a spleen artery module, 4-4 is a module fixing screw, 4-5 is an embolism simulation cylinder, 4-6 is an organ support column, 4-7 is an organ shell opening, and 4-8 is an organ return line;

[0037] 4-2-1 is the outer shell of the kidney, 4-2-2 is the main trunk of the renal artery, and 4-2-3 is the branch of the renal artery;

[0038] 4-3-1 is the outer shell of the spleen, 4-3-2 is the main trunk of the splenic artery, and 4-3-3 is the branch of the splenic artery;

[0039] 4-5-1 is a connecting sleeve, 4-5-2 is the initial end of the reflux line in the organ, 4-5-3 is the end of the organ artery, and 4-5-4 is a filter sponge. DETAILED DESCRIPTION

[0040] The present invention is further described in detail below with reference to specific embodiments and accompanying drawings.

[0041] The in vitro simulation device for vascular interventional embolization therapy designed by the present invention (hereinafter referred to as the in vitro simulation device) has an overall structure as follows Figure 1 As shown in Figure 2, the structure of the basic vascular module is as follows: Figure 2 The structure of the renal artery module is shown in Figure 3 The structure of the liver artery module is shown in Figure 4 The structure of the splenic artery module is shown in Figure 5 As shown, the internal and connected structures of the embolism simulation cylinder are as follows Figure 6 As shown, the structure of the cavity reflux support column is as follows Figure 7 shown.

[0042] The in vitro simulation device of the present invention comprises a pulsating pump 1 , a supporting structure 2 , a basic blood vessel module 3 , and an organ artery module 4 .

[0043] The pulsating pump 1 comprises a pulsating pump output end 1 - 1 and a pulsating pump input end 1 - 2 , and the pulsating pump 1 is placed in the blood pumping area 2 - 1 of the supporting structure 2 .

[0044] The support structure 2 includes a blood pumping area 2-1, an embolism simulation area 2-2, a reflux area 2-3, a middle partition 2-4, a liquid inlet pipe 2-5, a liquid discharge port plugging head 2-6, a liquid injection port plugging head 2-7, liquid in the tank 2-8, a blood storage tank 2-9, and a cavity reflux support column 2-10. The support structure 2 is divided into two layers, the upper layer includes a blood pumping area 2-1 for placing a pulsating pump 1, an embolism simulation area 2-2 for placing a basic blood vessel module 3 and an organ artery module 4, and a reflux area 2-3 for placing a terminal reflux pipeline; the lower layer is a blood storage tank 2-9 as a whole. The upper and lower layers share the middle partition 2-4. A liquid discharge port is provided at the bottom of the blood storage tank 2-9 for releasing the liquid in the tank to the outside, and a liquid discharge port plugging head 2-6 connected by a thread is provided at the liquid discharge port for blocking and opening the liquid discharge port. The above-mentioned blood pumping area 2-1 is connected to the blood storage tank 2-9 through the liquid inlet tube 2-5. One end of the liquid inlet tube 2-5 is connected to the input end 1-2 of the pulsating pump, and the other end is close to the bottom of the blood storage tank, which is the channel for the liquid 2-8 in the tank to enter the pulsating pump 1. There are two holes on the middle partition 2-4 of the blood pumping area 2-1, one is a through hole for passing the liquid inlet tube 2-5, and the other is a threaded hole, which is a liquid injection port. There is a liquid injection port plugging head 2-7 connected by a thread to plug and open the liquid injection port. The pulsating pump 1 is placed in the blood pumping area 2-1, and the output end 1-1 of the pulsating pump is connected to the thoracic aorta port 3-1 of the basic blood vessel module 3. A plurality of cavity reflux support columns 2-10 are installed on the middle partition 2-4 of the embolism simulation area 2-2 through a threaded connection to support the organ artery module 4 and introduce the liquid passing through the organ artery module 4 into the blood storage tank 2-9 through the hollow cavity. There are two hollow reflux support columns 2-10 on the middle partition 2-4 of the reflux area 2-3, which are connected to the middle partition 2-10 through threaded connection and connected to the end of the femoral artery 3-8 on the basic vascular module 3 for liquid reflux to the blood storage tank 2-9.

[0045] The basic blood vessel module 3 includes bilateral femoral arteries 3-8, abdominal aorta 3-6, thoracic aorta 3-1, bilateral renal arteries 3-5, hepatic artery 3-4, and splenic artery 3-3. The shape and arrangement of each arterial blood vessel conform to the normal human blood vessel distribution. The bilateral femoral arteries 3-8 are provided with puncture branches 3-7, which are the locations for microcatheter intervention for injecting embolic drugs. The ends of the bilateral femoral arteries 3-8 are provided with other artery equal resistance modules 3-9, which are used to simulate the blood flow resistance caused by other unrepresented blood vessels. The ends of the bilateral renal arteries 3-5, hepatic artery 3-4, and splenic artery 3-3 can be connected to the organ artery module 4 through a Luer connector, and can also be blocked by a Luer connector at the place where the organ artery module 4 is not installed.

[0046] The organ artery module 4 mainly includes a renal artery module 4-2, a hepatic artery module 4-1, a splenic artery module 4-3, a module fixing screw 4-4, an embolism simulation cylinder 4-5, an organ internal support column 4-6, an organ shell opening 4-7, and an organ internal return pipeline 4-8. The organ shells of each organ artery module (kidney shell 4-2-1, liver shell 4-1-1, spleen shell 4-3-1) are made of transparent hard plastic and are half-section models, which are used to express the organ shape and fix and support the blood vessels in the organ through a number of organ internal support columns 4-6. The lower part of the organ internal support column 4-6 is connected to the organ shell (kidney shell 4-2-1, liver shell 4-1-1, spleen shell 4-3-1) by threaded connection, and the upper part is a semi-cylindrical support body, which is used to support the blood vessels in the organ and the embolism simulation cylinder 4-5. The half-cut organ shell (kidney shell 4-2-1, liver shell 4-1-1, spleen shell 4-3-1) model has three organ shell openings 4-7 at the bottom for the return line 4-8 in the organ. The blood vessels in each organ artery module 4 include the organ aorta (hepatic artery trunk 4-1-3, renal artery trunk 4-2-2, splenic artery trunk 4-3-2) and the main branches under the aorta (hepatic artery branch 4-1-2, renal artery branch 4-2-3, splenic artery branch 4-3-3), and each branch end 4-5-3 is connected to an embolism simulation cylinder 4-5. The embolism simulation cylinder 4-5 includes a connecting sleeve 4-5-1, an initial end 4-5-2 of the internal organ return line, an end 4-5-3 of the organ artery branch, and a filter sponge 4-5-4. One end of the connecting sleeve 4-5-1 is threaded and threadedly connected to the initial end 4-5-2 of the internal organ return line, and the other end is a double-layer tower structure, which is connected to the end 4-5-3 of the organ artery branch by plugging and unplugging. The filter sponge 4-5-4 is normally in a truncated cone shape and is squeezed into the connecting sleeve 4-5-1. Therefore, the grid structure of the filter sponge in the sleeve changes from large to small in the direction of blood flow, which is used to simulate the characteristics of the organ's blood vessel diameter constantly decreasing. When the embolic agent and blood flow through the cylinder, the embolic agent particles will be intercepted by the filter sponge and continuously accumulated until completely blocked, which is consistent with the principle of embolization treatment. The above-mentioned filter sponge 4-5-4 can be replaced with different specifications according to actual conditions. The blood vessels of the organ artery module 4 can be 3D printed through the patient's imaging data and the blood vessel reconstruction by commercial software, and the material is highly transparent soft silicone. Therefore, it can better reproduce the real blood vessel shape and blood vessel state, and can be modified according to the specific condition.

[0047] The in vitro simulation device for vascular interventional embolization therapy designed by the present invention specifically simulates the embolization surgery process as follows (taking renal artery embolization as an example):

[0048] Remove the sealing head 2-7 of the liquid injection port, inject a proper amount of blood (blood-like) 2-8 into the blood storage tank 2-9, turn on the pulsating pump 1, and adjust the relevant programs so that the output end 1-2 of the pulsating pump injects blood (blood-like) 2-8 with a frequency and flow rate similar to that of the human heart into the basic vascular module 3. At this time, a liquid circuit similar to the human blood circulation can be seen in the in vitro simulation device. The interventional physician or experimenter inserts the interventional catheter into the femoral artery 3-8 through the interventional puncture branch 3-7, pushes the catheter to a renal artery branch 4-2-3 under human eyes, pushes the embolic agent into the renal artery branch 4-2-3 through the interventional catheter, and the embolic agent flows with the liquid in the in vitro simulation device to the embolization simulation cylinder 4-5, and accumulates continuously in the embolization simulation cylinder 4-5. At this time, the liquid flow in the internal organ return line 4-8 corresponding to the renal artery branch 4-2-3 is reduced, and finally the embolization simulation cylinder 4-5 is completely blocked by the filter sponge 4-5-4, and no liquid flows in the internal organ return line 4-8. It indicates that the simulation of the embolization operation process is completed. The interventional catheter is withdrawn, and the simulation process of this embolization operation is over. When the embolization operation is simulated again for this area, the embolization simulation cylinder 4-5 of this area is removed, the internal filter sponge 4-5-4 is replaced, and the embolization simulation cylinder 4-5 is reinstalled, and the next simulation process can be continued.

[0049] Hepatic artery embolization and splenic artery embolization can also be simulated through the above process in the corresponding organ artery module 4. Even for organs not shown in the present invention, the simulation of embolization surgery can be performed through the above simulation method.

[0050] Experiments show that the in vitro simulation device for vascular interventional embolization therapy designed by the present invention has a simple structure, low cost, and can be repeatedly operated. It also has the characteristics of high vascular restoration, targeted modification for specific conditions, transparent visualization, and relatively accurate simulation of embolization sites and embolization processes. It can be used as an auxiliary device for doctors to practice and teach interventional embolization surgery, familiarize themselves with the surgical process, and cultivate their hand feeling. It can also be used to assist in the design and verification of the reliability and safety of the embolic agent injection robot system.

[0051] Matters not described in the present invention are applicable to the known technologies.

[0052] The above is a detailed description of the implementation of the present invention, but the content described is the preferred implementation process of the present invention and cannot be considered to limit the protection scope of the claims of this application. All equivalent changes and improvements made within the scope of the claims of this application should fall within the protection scope of the claims of this application.

Claims

1. An in vitro simulation device for vascular interventional embolization therapy, characterized in that: include: Pulsating pump, organ artery module, basic blood vessel module, supporting structure; including: The pulsating pump is used to supply blood to the simulated heart pulsation; The organ artery module is used to simulate the arterial blood vessels at the embolism site and the local capillary network of the organ where the embolism occurs; The basic blood vessel module is used to simulate the basic blood vessel pathway for the interventional catheter to enter the body; The support structure is used to support and fix each module to maintain the shape of the blood vessel; The support structure is divided into two layers, the upper layer includes a blood pumping area for placing a pulsating pump, an embolism simulation area for placing basic blood vessel modules and organ artery modules, and a return area for placing a terminal return line; the lower layer is a blood storage tank as a whole; the upper and lower layers are separated by a shared middle partition; The bottom of the blood storage tank is provided with a liquid discharge port for releasing the liquid in the tank to the outside, and a plugging head connected by a thread is provided at the liquid discharge port for sealing and opening the liquid discharge port; The blood pumping area is connected to the blood storage tank through a liquid inlet tube, one end of which is connected to the input end of the pulsating pump, and the other end of the liquid inlet tube is close to the bottom of the blood storage tank, which is a channel for the liquid in the tank to enter the pulsating pump; The middle partition of the blood pumping area is provided with two holes, one of which is a through hole for passing the liquid inlet tube, and the other is a threaded hole, which is a liquid injection port and has a plugging head connected by threads for plugging and opening the liquid injection port; A pulsating pump is placed in the blood pumping area, and an output end of the pulsating pump is connected to the thoracic aorta orifice of the basic vascular module; A plurality of hollow reflux support columns are installed on the middle partition of the embolism simulation area through threaded connection to support the organ artery module and introduce the liquid passing through the organ artery module into the blood storage tank through the hollow cavity; There are two hollow reflux support columns on the middle partition of the reflux zone, which are connected to the middle partition through threaded connection and connected to the left and right external arteries on the basic vascular module for liquid reflux to the blood storage tank; The basic vascular module is used to simulate the basic vascular pathway for the interventional catheter to enter the body, including bilateral femoral arteries, abdominal aorta, thoracic aorta, bilateral renal artery branches, hepatic artery branches, and splenic artery branches; the bilateral femoral arteries are provided with puncture branches, which are the locations for microcatheter intervention for injecting embolic drugs; the ends of the bilateral renal artery branches, hepatic artery branches, and splenic artery branches are connected to the organ artery module through a Luer connector; where the organ artery module is not installed, the Luer connector is used for occlusion; The organ artery module mainly includes a renal artery module, a hepatic artery module and a splenic artery module, which are respectively used to simulate renal artery embolization, hepatic artery embolization and splenic artery embolization; the organ shell of each organ artery module is made of transparent hard plastic and is a half-section model, which is used to show the organ shape and fix and support the blood vessels in the organ through a number of internal organ support columns; the lower part of the internal organ support column is connected to the organ shell through a threaded connection, and the upper part is a semi-cylindrical support body, which is used to support the blood vessels in the organ and the embolism simulation cylinder; In the supporting structure, a drain port is provided at the bottom of the blood storage tank for releasing the liquid in the tank to the outside, and a plugging head connected by a thread is provided at the drain port for plugging and opening the drain port; In the support structure, two holes are opened on the middle partition of the blood pumping area, one is a through hole for passing the liquid inlet tube, and the other is a threaded hole, which is a liquid injection port and has a sealing head connected by threads to seal and open the liquid injection port.

2. The in vitro simulation device for vascular interventional embolization therapy according to claim 1, characterized in that: In the organ artery module, the bottom of the half-sectioned organ shell model has three organ shell openings for passing the return pipeline in the organ; the blood vessels in each organ artery module include the organ aorta and the main branches under the aorta, and the end of each branch is connected to an embolism simulation cylinder.

3. The in vitro simulation device for vascular interventional embolization therapy according to claim 2, characterized in that: In the organ artery module, the embolism simulation cylinder includes a connecting sleeve, an initial end of an intra-organ return line, an end of an organ artery branch and a filter sponge. One end of the connecting sleeve has a thread, which is threadedly connected to the initial end of the intra-organ return line, and the other end is a double-layer tower structure, which is connected to the end of the organ artery branch by plugging and unplugging.

4. The in vitro simulation device for vascular interventional embolization therapy according to claim 3, characterized in that: In the organ artery module, the filter sponge is normally in a truncated cone shape and is squeezed into the connecting sleeve so that the filter sponge grid structure in the sleeve changes from large to small in the direction of blood flow, which is used to simulate the characteristic of the organ's blood vessel diameter constantly decreasing. When the embolic agent and blood flow through the cylinder, the embolic agent particles are intercepted by the filter sponge and continuously accumulated until they are completely blocked, which is consistent with the treatment principle of embolization.

5. The in vitro simulation device for vascular interventional embolization therapy according to any one of claims 1 to 4, characterized in that: The blood vessels of the organ artery module are made by 3D printing based on the patient's imaging data and after blood vessel reconstruction using commercial software. The material is highly transparent soft silicone.

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