Retinal and Optic Nerve Protective Electrical Stimulation Device

Abstract

The present invention belongs to the technical field of medical devices, and particularly relates to a retinal and optic nerve protective electrical stimulation device. The stimulation pulses output by the stimulator are used for trans-retinal and trans-orbital electrical stimulation of nerve tissues on the visual conduction pathway through amplified electrodes. The present invention solves the problem in the prior art that there is a lack of research on non-invasive trans-retinal electrical stimulation and trans-orbital electrical stimulation of the eye and their electrical stimulation devices, and has the beneficial technical effect of filling the blank in the application of non-invasive trans-retinal and trans-orbital electrical stimulation devices for the eye.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a retinal and optic nerve protective electrical stimulation device. Background Art

[0002] Traumatic optic nerve injury can lead to retrograde apoptosis of retinal ganglion cells, while transcorneal electrical stimulation can increase cell survival rate. We monitored the morphology and survival of retinal ganglion cells after optic nerve injury in vivo by using retinal confocal method. Optic nerve injury was performed on rats, and the number and morphology of retinal ganglion cells were recorded before injury and 3, 7, and 15 days after injury. At 3 days after optic nerve injury, transcorneal electrical stimulation was used and it was found that a large number of retinal ganglion cells survived in the stimulation group compared with the sham stimulation group. The difference between the two groups became smaller at 7 days and disappeared at 15 days. Morphological analysis showed that in the early stage of injury, the average cell morphology in the sham stimulation group changed significantly, and most cells were swollen and apoptotic, while the cell morphology in the stimulation group did not change significantly. Therefore, compared with the sham stimulation group, transcorneal electrical stimulation can produce a protective effect on damaged cells, maintain the normal cell morphology, and improve the survival rate of damaged cells.

[0003] In vitro, electrical stimulation of the transected optic nerve can promote axon regeneration and improve the survival of retinal ganglion cells. The research results show that electrical stimulation has a protective effect on the optic nerve. Since optic nerve injury in clinical practice mostly occurs in a closed state, especially partial injury is common, and this completely transected optic nerve injury under experimental conditions cannot well simulate the clinical situation, so the relevant research needs to be further improved.

[0004] As a new physical therapy, electrical stimulation of the retina and optic nerve can activate the visual system (retina and optic nerve) and has a protective effect on damaged neurons. This becomes the basis for the application of electrical stimulation devices in ophthalmic clinics, and it is expected to treat various retinal and optic nerve diseases, such as retinitis pigmentosa, traumatic optic neuropathy, anterior ischemic optic neuropathy, and retinal artery occlusion, etc. At present, many studies attempt to elaborate the mechanism of action of electrical stimulation of the visual system, mostly using transcorneal electrical stimulation or directly performing electrical stimulation on the damaged optic nerve in an open state, but both methods have defects: First, for transcorneal electrical stimulation, the stimulating electrode needs to be applied on the corneal surface under topical anesthesia, and patients cannot tolerate it for a long time. And directly performing electrical stimulation on the damaged optic nerve and retina in an open state is even impossible in clinical practice.

[0005] In summary, the research on non-invasive transretinal electrical stimulation or transorbital electrical stimulation of the eye and its electrical stimulation device is of great significance for the development of ophthalmic medicine. Summary of the Invention

[0006] The present invention provides a retinal and optic nerve protective electrical stimulation device to solve the problem in the prior art proposed in the above background technology that the research on non-invasive transretinal electrical stimulation or transorbital electrical stimulation and its electrical stimulation device in ophthalmology is of great significance for the development of ophthalmology.

[0007] The technical problem solved by the present invention is achieved by adopting the following technical solution: A retinal and optic nerve protective electrical stimulation device includes a stimulator, and the stimulation pulses output by the stimulator are used for transretinal or transorbital electrical stimulation of nerve tissues on the visual conduction pathway through an amplification electrode.

[0008] Furthermore, the stimulator outputs corresponding stimulation pulses by automatically controlling the stimulation time and adjusting the pulse waveform, pulse width, frequency, and amplitude.

[0009] Furthermore, the amplification electrode includes a recovery electrode group and a stimulation electrode group. The recovery electrode group includes a recovery electrode attached to the lower part of the left orbit and another recovery electrode attached to the lower part of the right orbit. The stimulation electrode group includes a stimulation electrode attached to the upper part of the left orbit and another stimulation electrode attached to the upper part of the right orbit.

[0010] Furthermore, one stimulation electrode and one recovery electrode are distributed on the inner surface of the left cover of an eye mask, and the other stimulation electrode and the other recovery electrode are distributed on the inner surface of the right cover of the eye mask.

[0011] Furthermore, the stimulator includes a stimulation circuit, and the stimulation circuit includes a programmable control chip U1;

[0012] The first control end of the programmable control chip U1 is output-connected to a stimulation pulse generation circuit A1;

[0013] The second control end of the programmable control chip U1 is output-connected to a recovery pulse generation circuit A2;

[0014] The third control end of the programmable control chip U1 is output-connected to another stimulation pulse generation circuit A3;

[0015] The fourth control end of the programmable control chip U1 is output-connected to another recovery pulse generation circuit A4.

[0016] Furthermore, both the stimulation pulse generation circuit A1 and another stimulation pulse generation circuit A3 adopt the same stimulation pulse generation circuit;

[0017] The stimulation pulse generating circuit includes a variable resistor R1. One end of the variable resistor R1 is connected to the positive power supply, and the other end is connected to the first control terminal or the third control terminal of the programmable control chip U1, and is connected to one end of a capacitor C1 and to the base of a transistor Q1. The other end of the capacitor C1 is grounded. The collector of the transistor Q1 is connected to the positive power supply through a resistor R2 and to the base of a transistor Q2 through a resistor R3. The emitter of the transistor Q1 is grounded. The resistor R3 is grounded in series with a resistor R5. The collector of the transistor Q2 is connected to one end of a resistor R4 and to a stimulation electrode or another stimulation electrode. The other end of the resistor R4 is connected to the positive power supply. The emitter of the transistor Q2 is grounded.

[0018] Further, both the one recovery pulse generating circuit A2 and the other recovery pulse generating circuit A4 adopt the same recovery pulse generating circuit;

[0019] The recovery pulse generating circuit includes a variable resistor R1'. One end of the variable resistor R1' is connected to the ground, and the other end is connected to the first control terminal or the third control terminal of the programmable control chip U1, and is connected to one end of a capacitor C1' and to the base of a transistor Q1'. The other end of the capacitor C1' is connected to the negative power supply. The collector of the transistor Q1' is connected to the ground through a resistor R2' and to the base of a transistor Q2' through a resistor R3'. The emitter of the transistor Q1' is connected to the negative power supply. The resistor R3' is connected to the negative power supply in series with a resistor R5'. The collector of the transistor Q2' is connected to one end of a resistor R4' and is connected to a recovery electrode or another recovery electrode through a phase-shifting capacitor C2. The other end of the resistor R4' is connected to the ground. The emitter of the transistor Q2' is connected to the negative power supply.

[0020] Further, the programmable control chip U1 adopts a digital signal processor DSP AVP32F335.

[0021] Further, the preferred scheme of the stimulation pulse is a biphasic square pulse, with a frequency of 20 Hz, a stimulation time of 60 minutes, a stimulation current of 100 μA, and a pulse width of 1 ms / phase.

[0022] Further, the stimulation electrode is a metal ring with a diameter of 3 mm.

[0023] Beneficial technical effects:

[0024] In this patent, the stimulating pulses output by the stimulator are used to electrically stimulate the nerve tissue on the visual conduction pathway through the amplification electrode across the retina or across the orbit. Since the preclinical research results of using transcorneal electrical stimulation show that this physical therapy of electrical stimulation is applicable to early intervention after injury. In the early stage after optic nerve injury, transcorneal electrical stimulation can significantly improve the survival rate of retinal ganglion cells, protect the function of residual optic nerve fibers, and provide the possibility for the structural reconstruction of damaged nerve fibers. However, the observation of the protective effect of transcorneal electrical stimulation on the retina and optic nerve is limited to the early stage after injury, when the death of retinal ganglion cells has not fully occurred. Then, in addition to the early electrical stimulation after injury can improve the intraocular environment, can electrical stimulation support the long-term survival of retinal ganglion cells? In order to understand this long-term effect, there is an urgent need for a non-invasive, tolerable, portable and simple-to-operate ocular electrical stimulation device to cooperate with this long-term electrical stimulation observation. Based on the above research results, this invention emits stimulating pulses through a stimulator, and then outputs the stimulating current of the stimulating pulses to an electrode. After the current is amplified by the electrode, it acts on the tissue around the orbit, forming a current across the retina and across the orbit to stimulate the nerve tissue on the visual conduction pathway, thereby producing a protective effect on the damaged retina and optic nerve. Therefore, this invention proposes a retinal and optic nerve protective electrical stimulation device, filling the blank of the application of non-invasive and portable ocular transretinal and transorbital electrical stimulation devices. Brief Description of the Drawings

[0025] Figure 1 is a schematic structural diagram of this device;

[0026] Figure 2 is a module diagram of the stimulating circuit of this device;

[0027] Figure 3 is a circuit diagram of the stimulating pulse generating circuit of this device;

[0028] Figure 4 is a circuit diagram of the recovery pulse generating circuit of this device;

[0029] Figure 5 is an application schematic diagram of this device; Detailed Description of the Preferred Embodiment

[0030] The following further describes the present invention with reference to the accompanying drawings:

[0031] In the figure:

[0032] 1 - stimulator; 2 - amplification electrode, 3 - recovery electrode, 4 - stimulating electrode, 5 - one stimulating electrode, 6 - one recovery electrode, 7 - another stimulating electrode, 8 - another recovery electrode, 9 - stimulating electrode group, 10 - recovery electrode group, 11 - eye mask;

[0033] U1 - Programmable control chip; A1 - A stimulation pulse generation circuit; A2 - A recovery pulse generation circuit; A3 - Another stimulation pulse generation circuit; A4 - Another recovery pulse generation circuit; R1 - Adjustable resistor; C1 - Capacitor; Q1 - Transistor; C1 - Capacitor; Q1 - Transistor; R2 - Resistor; R3 - Resistor; Q2 - Transistor; R5 - Resistor; R4 - Resistor;

[0034] R1’ - Adjustable resistor; C1’ - Capacitor; Q1’ - Transistor; C1’ - Capacitor; Q1’ - Transistor; R2’ - Resistor; R3’ - Resistor; Q2’ - Transistor; R5’ - Resistor; R4’ - Resistor.

[0035] Embodiment:

[0036] In this embodiment: As Figure 1 shown, a retinal and optic nerve protective electrical stimulation device includes a stimulator 1, and the stimulation pulses output by the stimulator 1 are used to electrically stimulate the nerve tissues on the visual conduction pathway across the retina or across the orbit through the amplification electrode 2.

[0037] The stimulator 1 outputs corresponding stimulation pulses by automatically controlling the stimulation time and adjusting the pulse waveform, pulse width, frequency, and amplitude.

[0038] Since the stimulation pulses output by the stimulator are electrically stimulated across the retina or across the orbit through the amplifying electrodes to the neural tissue in the visual conduction pathway, and since the results of preclinical studies using transcorneal electrical stimulation have shown that this treatment is also suitable for intervention after early injury, it is first proposed that transcorneal electrical stimulation can significantly increase the number of retinal ganglion cells after optic nerve transection, and the stimulation parameters that can produce the best neuroprotective effect are determined in detail. Transcorneal electrical stimulation is applied after optic nerve crush injury. This injury model provides an opportunity for the functional recovery of residual nerve fibers and the possibility of recovery of axonal structure. Interestingly, this method leads to functional recovery. However, the authors only observed the situation six days after the injury. At this time, the death of retinal ganglion cells has not yet completely occurred. In order to elaborate on these observations, after the injury, In addition to improving the environment within the first week, can transcorneal electrical stimulation support the long-term survival of retinal ganglion cells? In order to understand this long-term effect, we performed electrical stimulation on rats immediately after injury. We also performed electrical stimulation for a period of time after injury, and used in vivo confocal neural imaging methods to repeatedly observe retinal ganglion cells in the same animal in real time. The present invention is based on the above research results. The stimulator sends out stimulation pulses, and then outputs the stimulation current of the stimulation pulses to the electrodes. After current amplification, the electrodes act on the surface of the skin around the retina, thereby stimulating the neural tissue on the visual conduction pathway, achieving the effect of retinal ganglion cell regeneration. Therefore, the present invention proposes a retinal and optic nerve protective electrical stimulation device, which fills the gap in the application of non-damaged eye trans-retinal and trans-orbital electrical stimulation devices.

[0039] like Figure 5 As shown, the amplifying electrode 2 includes a recovery electrode group 10 and a stimulation electrode group 9. The recovery electrode group 10 includes a recovery electrode 6 attached to the bottom of the left eye socket and another recovery electrode 8 attached to the bottom of the right eye socket. The stimulation electrode group 9 includes a stimulation electrode 5 attached to the top of the left eye socket and another stimulation electrode 7 attached to the top of the right eye socket.

[0040] Since the amplifying electrode includes a recovery electrode group and a stimulation electrode group, the recovery electrode group includes a recovery electrode attached to the bottom of the left eye socket and another recovery electrode attached to the bottom of the right eye socket, and the stimulation electrode group includes a stimulation electrode attached to the top of the left eye socket and another stimulation electrode attached to the top of the right eye socket, since there are a total of four electrodes in this eye mask, two stimulation electrodes and two recovery electrodes, after being worn on the human face, the positions of the electrodes are respectively located above and below the eye sockets. Since the stimulation electrodes are distributed above the eye sockets of both eyes and below the eye sockets of both eyes, the current enters the neural tissue on the visual conduction pathway through the top of the eye socket, and then passes through the bottom of the eye socket, thereby achieving the effect of long-term survival of retinal ganglion cells through transcorneal electrical stimulation.

[0041] One of the stimulating electrodes 5 and one of the recovery electrodes 6 are distributed on the inner surface of the left cover of an eye mask 11, and the other stimulating electrode 7 and the other recovery electrode 8 are distributed on the inner surface of the right cover of the eye mask 11.

[0042] Since one of the stimulating electrodes and one of the recovery electrodes are distributed on the inner surface of the left cover of an eye mask, and the other stimulating electrode and the other recovery electrode are distributed on the inner surface of the right cover of the eye mask, with the eye mask as a carrier, the stimulating electrodes and the recovery electrodes are encapsulated on the corresponding inner surfaces of the eye mask.

[0043] As Figure 2 shown, the stimulator 1 includes a stimulating circuit, and the stimulating circuit includes a programmable control chip U1;

[0044] The output of the first control end of the programmable control chip U1 is connected to a stimulating pulse generating circuit A1;

[0045] The output of the second control end of the programmable control chip U1 is connected to a recovery pulse generating circuit A2;

[0046] The output of the third control end of the programmable control chip U1 is connected to another stimulating pulse generating circuit A3;

[0047] The output of the fourth control end of the programmable control chip U1 is connected to another recovery pulse generating circuit A4.

[0048] Since the stimulator includes a stimulating circuit, and the stimulating circuit includes a programmable control chip U1, a stimulating pulse generating circuit A1, a recovery pulse generating circuit A2, another stimulating pulse generating circuit A3, and another recovery pulse generating circuit A4, the above circuits are distributed in an array structure and are interconnected. Since the control chip U1 outputs control signals to the stimulating pulse generating circuit A1 and A3, and the recovery pulse generating circuit A2 and A4 respectively, the stimulating pulse generating circuit and the recovery pulse generating circuit output bipolar square pulses, and the parameters of the bipolar square pulses are 1 ms / phase, frequency 20 Hz, and energy 100 μA. The topological structure of this module adopts a distributed array structure, which not only retains its synchronous structure but is also independent of each other. Through an isolation circuit, cross-talk between circuits is prevented.

[0049] As Figure 3 shown, both the stimulating pulse generating circuit A1 and another stimulating pulse generating circuit A3 adopt the same stimulating pulse generating circuit;

[0050] The stimulation pulse generating circuit includes a variable resistor R1. One end of the variable resistor R1 is connected to the positive power supply, and the other end is connected to the first control terminal or the third control terminal of the programmable control chip U1, and is connected to one end of a capacitor C1 and the base of a transistor Q1. The other end of the capacitor C1 is grounded. The collector of the transistor Q1 is connected to the positive power supply through a resistor R2 and to the base of a transistor Q2 through a resistor R3. The emitter of the transistor Q1 is grounded. The resistor R3 is grounded in series with a resistor R5. The collector of the transistor Q2 is connected to one end of a resistor R4 and to a stimulation electrode 5 or another stimulation electrode 7. The other end of the resistor R4 is connected to the positive power supply. The emitter of the transistor Q2 is grounded.

[0051] As Figure 4 shown, the one recovery pulse generating circuit A2 and the other recovery pulse generating circuit A4 both adopt the same recovery pulse generating circuit;

[0052] The recovery pulse generating circuit includes a variable resistor R1'. One end of the variable resistor R1' is connected to the ground, and the other end is connected to the first control terminal or the third control terminal of the programmable control chip U1, and is connected to one end of a capacitor C1' and the base of a transistor Q1'. The other end of the capacitor C1' is connected to the negative power supply. The collector of the transistor Q1' is connected to the ground through a resistor R2' and to the base of a transistor Q2' through a resistor R3'. The emitter of the transistor Q1' is connected to the negative power supply. The resistor R3' is connected to the negative power supply in series with a resistor R5'. The collector of the transistor Q2' is connected to one end of a resistor R4', and through a phase-shifting capacitor C2 to a recovery electrode 6 or another recovery electrode 8. The other end of the resistor R4' is connected to the ground. The emitter of the transistor Q2' is connected to the negative power supply.

[0053] Since the one stimulation pulse generating circuit A1 and the other stimulation pulse generating circuit A3 both adopt the same stimulation pulse generating circuit, and the one recovery pulse generating circuit A2 and the other recovery pulse generating circuit A4 both adopt the same recovery pulse generating circuit. Because it consists of a relaxation oscillator composed of a unijunction transistor Q, resistors R, a potentiometer, and a capacitor C, and an amplifier composed of transistors Q and Q'. By adjusting the potentiometer, the oscillation frequency of the relaxation oscillator can be changed to obtain a time-base pulse of 0.1 ms to 15 s. This pulse is amplified by the amplifier and then outputs a square-wave pulse as the input signal of the time counter. Importantly, the stimulation pulse generating circuit A1 does not have a phase-shifting capacitor C, while the recovery pulse generating circuit A2 has a phase-shifting capacitor C. The two circuits only differ by a phase-shifting capacitor C, and this phase-shifting capacitor C exactly separates the stimulation pulse and the recovery pulse by one phase. Since a bidirectional pulse circuit is adopted, a biphasic square pulse is formed. This biphasic square pulse stimulates the optic nerve both up and down, improving the stimulation effect.

[0054] The programmable control chip U1 uses the digital signal processor DSP AVP32F335.

[0055] Since the programmable control chip U1 uses the digital signal processor DSP AVP32F335, and AVP32F335 is a floating-point DSP that adopts static CMOS technology, the system main frequency reaches 120MHz (250Mhz for the upgraded version). It has a 3.3Vio design but the core uses 1.5v. It adopts the Harvard architecture, integrates a single-precision floating-point operation FPU, and provides a standard mathematical calculation table. It internally integrates a 1.5V LDO and supports media access control at the same time. Externally, it uses 6-channel DMA, PWM supports 18-way output, 6 time input captures, and the ADC has 16 channels. There are two quadrature encoding interfaces. In terms of timer resources, it supports 3 32-bit system timers and another 17 general-purpose timers. In terms of communication interfaces, it internally integrates a CAN transceiver, and the upgraded version of the chip also supports an Ethercat bus transceiver. The package adopts BGA and LQFP recommended by 176.

[0056] The preferred scheme of the stimulation pulse is a biphasic square pulse, with a frequency of 20Hz, a stimulation time of 60 minutes, a stimulation current of 100μA, and a pulse width of 1ms / phase.

[0057] Since the stimulator outputs corresponding stimulation pulses by automatically controlling the stimulation time and adjusting the pulse width, frequency, and amplitude of the pulse waveform, the preferred scheme of the stimulation pulse is a biphasic square pulse, with a frequency of 20Hz, a stimulation time of 60 minutes, a stimulation current of 100μA, and a pulse width of 1ms / phase. Since the patient wears an eye mask, this eye mask is a stimulation device that can output current. At the same time, there is a remote control that can adjust the electrical parameters output by the electrodes on the eye mask and control the stimulation time. If the patient does not want to adjust the parameters by himself, there are some stimulation parameters corresponding to different diseases stored in the machine, and he can directly select them.

[0058] The stimulation electrode 4 is a metal ring with a diameter of 3mm.

[0059] The amplification electrode adopted includes a recovery electrode and a stimulation electrode. The recovery electrode is attached to the skin surface, and the stimulation electrode is attached to the corneal surface. The stimulation electrode is a metal ring with a diameter of 3mm. Since a biphasic square pulse, 1ms / phase, 20Hz, and 100μA are used to stimulate for 60 minutes. Electrical stimulation is applied immediately after the injury and 11 days after the injury. The stimulation electrode is a metal ring with a diameter of 3mm, and the reference electrode is fixed on the ear.

[0060] Working principle:

[0061] In this patent, the stimulating pulses output by the stimulator pass through the amplification electrode to perform transretinal or transorbital electrical stimulation on the nerve tissue in the visual conduction pathway. Since the preclinical research results of using transcorneal electrical stimulation show that this treatment is also applicable to the intervention after early injury, it is first proposed that after optic nerve transection, transcorneal electrical stimulation can significantly increase the number of retinal ganglion cells, and the stimulation parameters that can produce the best neuroprotective effect are determined in detail. After optic nerve crush injury, transcorneal electrical stimulation is applied. This injury model provides an opportunity for the functional recovery of the remaining nerve fibers and makes it possible for the axonal structure to recover. Interestingly, this method leads to functional recovery. However, the author only observed the situation six days after the injury, when the death of retinal ganglion cells has not fully occurred. In order to elaborate on these observations, within the first week after the injury, in addition to being able to improve the environment, can transcorneal electrical stimulation support the long-term survival of retinal ganglion cells? In order to understand this long-term effect, we electrically stimulated the rats immediately after the injury and also electrically stimulated them for a period of time after the injury. Using the in vivo confocal nerve imaging method, we observed the retinal ganglion cells in the same animal in real time and repeatedly. Based on the above research results, the present invention emits stimulating pulses through the stimulator, then outputs the stimulating current of the stimulating pulses to the electrode, and the electrode acts on the skin surface around the orbit after current amplification, thereby stimulating the nerve tissue in the visual conduction pathway, so as to produce a protective effect on the damaged retina and optic nerve. The present invention solves the problem in the prior art that there is a lack of research on non-invasive, simple-operation, portable transretinal and transorbital electrical stimulation of the eye and its electrical stimulation device, and has the beneficial technical effect of filling the blank in the application of non-invasive, simple-operation, portable transretinal and transorbital electrical stimulation devices for the eye.

[0062] Using the technical solution of the present invention, or those skilled in the art designing similar technical solutions inspired by the technical solution of the present invention and achieving the above technical effects shall fall within the protection scope of the present invention.

Claims

1. A retinal and optic nerve protective electrical stimulation device, characterized in that: The device comprises a stimulator, wherein the stimulation pulses output by the stimulator electrically stimulate the neural tissue on the visual conduction pathway across the retina and across the orbit via the amplifying electrode; The stimulator includes a stimulation circuit, and the stimulation circuit includes a programmable control chip U1; The first control terminal output of the programmable control chip U1 is connected to a stimulation pulse generating circuit A1; The second control terminal output of the programmable control chip U1 is connected to a recovery pulse generating circuit A2; The third control terminal output of the programmable control chip U1 is connected to another stimulation pulse generating circuit A3; The fourth control terminal output of the programmable control chip U1 is connected to another recovery pulse generating circuit A4; The stimulation pulse generating circuit A1 and the stimulation pulse generating circuit A3 both use the same stimulation pulse generating circuit; The stimulation pulse generating circuit includes an adjustable resistor R1, one end of the adjustable resistor R1 is connected to a positive power supply, the other end of the adjustable resistor R1 is connected to the first control terminal of the programmable control chip U1 or the third control terminal of the programmable control chip U1, and is connected to one end of the capacitor C1 and the base of the transistor Q1. The other end of the capacitor C1 is grounded. The collector of the transistor Q1 is connected to the positive power supply via the resistor R2 and to the base of the transistor Q2 via the resistor R3. The emitter of the transistor Q1 is grounded. The resistor R3 is connected to ground in series with the resistor R5. The collector of the transistor Q2 is connected to one end of the resistor R4 and is connected to one stimulation electrode or another stimulation electrode. The other end of the resistor R4 is connected to the positive power supply, and the emitter of the transistor Q2 is grounded. The one recovery pulse generating circuit A2 and the other recovery pulse generating circuit A4 both use the same recovery pulse generating circuit; The recovery pulse generating circuit includes an adjustable resistor R1', one end of which is connected to the ground, and the other end is connected to the first control terminal of the programmable control chip U1 or the third control terminal of the programmable control chip U1, and is connected to one end of the capacitor C1' and the base of the transistor Q1'. The other end of the capacitor C1' is connected to the negative power supply. The collector of the transistor Q1' is connected to the ground via the resistor R2' and is connected to the base of the transistor Q2' via the resistor R3'. The emitter of the transistor Q1' is connected to the negative power supply. The resistor R3' is connected to the negative power supply in series with the resistor R5'. The collector of the transistor Q2' is connected to one end of the resistor R4' and is connected to one recovery electrode or the other recovery electrode via the phase-shift capacitor C2. The other end of the resistor R4' is connected to the ground, and the emitter of the transistor Q2' is connected to the negative power supply.

2. The device according to claim 1, characterized in that The stimulator outputs corresponding stimulation pulses by automatically controlling the stimulation time and adjusting the pulse width, frequency and amplitude of the pulse waveform.

3. The device according to claim 1, characterized in that The amplifying electrode includes a recovery electrode group and a stimulation electrode group. The recovery electrode group includes a recovery electrode attached to the bottom of the left eye socket and another recovery electrode attached to the bottom of the right eye socket. The stimulation electrode group includes a stimulation electrode attached to the top of the left eye socket and another stimulation electrode attached to the top of the right eye socket.

4. The device according to claim 3, characterized in that The one stimulation electrode and the one recovery electrode are distributed on the inner surface of the left eye mask, and the other stimulation electrode and the other recovery electrode are distributed on the inner surface of the right eye mask.

5. The device according to claim 2, characterized in that: The programmable control chip U1 adopts a digital signal processor DSP AVP32F335.

6. The device according to claim 2, characterized in that The stimulation pulse is a biphasic square pulse with a frequency of 20 Hz, a stimulation time of 60 minutes, a stimulation current of 100 μA, and a pulse width of 1 ms / phase.

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