A multifunctional Chinese medicine oral liquid refining combined system

Abstract

The present invention relates to a multifunctional Chinese medicine oral liquid refining combined system, which is suitable for Chinese medicine oral liquid refining and preparation molding, and belongs to the field of Chinese medicine pharmaceutical equipment. It is mainly composed of a medicine boiling pot (1), a filter (2), and a refrigeration tank (3). The special feature is that the medicine boiling pot (1) is detachably connected to the filter (2) through a first feeding pipe (4), and at the same time, the refrigeration tank (3) is detachably connected to the filter (2) through a second feeding pipe (5), and the three form a medicine boiling pot-filter-refrigeration tank combined system. The present invention has a novel design, a reasonable structure, convenient operation, and precise control. It can continuously operate the whole process of boiling, filtering, and refrigeration, reduce the loss of medicine liquid, reduce energy consumption, save time and high efficiency, and can prevent the loss and change of photosensitive components, heat-sensitive components and volatile components, thereby improving the stability and controllability of the preparation.

Description

Technical Field

[0001] The invention relates to a multifunctional Chinese medicine oral liquid refining combined system, which is suitable for the Chinese medicine oral liquid preparation molding and refining process and belongs to the field of Chinese medicine pharmaceutical equipment. Background Art

[0002] The ingredients of oral liquid preparations of traditional Chinese medicine are complex, and most of them have the problem of precipitation after long-term storage. Studies have shown that most of the precipitated precipitates are polysaccharides, proteins, tannins, and may also be alkaloids and glycosides with poor water solubility. The usual method to solve the above problem is to boil the preparation liquid, filter it after refrigeration for a certain period of time, and then prepare, fill and sterilize the filtrate to obtain the finished oral liquid.

[0003] The purpose of boiling the oral liquid extract is to dissolve or form colloids with poor water solubility in the liquid medicine as much as possible through thermal reaction, so that it exists in a more stable state in the liquid medicine. Then, by extending the refrigeration time, the components that are still difficult to dissolve in the liquid medicine under this condition are precipitated, and then removed by filtering, so as to achieve the purpose of stable liquid medicine properties and long-term placement without precipitation. However, different Chinese medicine varieties require different boiling process parameters, such as boiling temperature, liquid medicine volume, filtering method, refrigeration temperature, whether to add adsorbent, whether to filter while hot, etc. The precipitation state in the prepared liquid is also different. Precipitation with high viscosity is easy to block the filter plate, increasing the difficulty of filtration, and too fine precipitation is easy to pass through the filter hole to reduce the filtration efficiency. In view of the common technical difficulties existing in the above-mentioned different oral liquid varieties, targeted technical solutions must be adopted to meet the needs of large-scale production.

[0004] According to the existing technology, the equipment used by Chinese medicine manufacturers is usually a medicine boiling pot, a cold storage pot, and a plate and frame filter. The medicine boiling pot is a fixed-volume pressure device with an interlayer that can be heated by steam; the storage pot is a fixed-volume insulation device with an interlayer that can pass refrigerant; the plate and frame filter is a filtering device that can be matched with fast filter paper or slow filter paper. The above three types of equipment are usually connected with a hose or a stainless steel pipe when in use, and the connection effect depends on the experience and concentration of the operator. In the process of forming or refining Chinese medicine liquid oral liquid preparations, the operation requires more than two people to cooperate, and the equipment has no protective measures. When an accident occurs during the operation, such as the spraying of the medicine liquid due to blockage, the operator cannot obtain effective protection. Under the existing equipment conditions, the boiling, filtering and refrigeration operations are inconvenient, the labor intensity is high, there is a lot of dirt on site, and it is easy to cause secondary pollution of the production environment, which does not meet the current requirements of cGMP for drug production.

[0005] In addition, some Chinese medicines contain photosensitive ingredients, heat-sensitive ingredients or volatile ingredients. When heated in traditional medicine boiling pots, the heat-sensitive ingredients and volatile ingredients will be lost, affecting the quality of the medicine. When using traditional plate and frame filters, there is a risk of oxidation or decomposition of the ingredients due to the contact of the medicine solution with air or light. Summary of the invention

[0006] Aiming at the common technical difficulties such as the volatilization and loss of photosensitive, heat-sensitive or volatile and oxidizable components in the existing cooking, filtering or refrigeration processes, as well as the inconvenient operation, high labor intensity, large amount of on-site dirt, and easy secondary pollution of the production environment in the molding process of Chinese medicine oral liquid preparations, and failure to meet the current cGMP requirements for drug production, the technical problem to be solved by the present invention is to provide a multifunctional Chinese medicine oral liquid refining combination system.

[0007] On the basis of the existing medicine-cooking tank, filter and refrigerating tank, the inventor connected the medicine-cooking tank, refrigerating tank and filter detachably through the feeding pipe, and the three formed a medicine-cooking tank-filter-refrigerating tank combination system, which realized the continuous operation of medicine-cooking, filtering and refrigerating, reduced the loss of medicine liquid, reduced energy consumption, saved time and was highly efficient, and could prevent the loss and change of photosensitive components, heat-sensitive components and volatile components, thus improving the stability and controllability of the preparation. In addition, the inventor made technical transformation to the interlayer of the medicine-cooking tank and the refrigerating tank, realized the interchangeability and replacement of the refrigerating tank and the medicine-cooking tank, and greatly increased the production capacity of the Chinese medicine oral liquid refining system without increasing the equipment investment.

[0008] The technical problem solved by the present invention is specifically achieved by the following technical solutions:

[0009] A multifunctional Chinese medicine oral liquid refining combined system is mainly composed of a medicine boiling pot 1, a filter 2, and a refrigeration tank 3. The special feature is that the medicine boiling pot 1 is detachably connected to the filter 2 through a first feeding pipe 4, and at the same time, the refrigeration tank 3 is detachably connected to the filter 2 through a second feeding pipe 5, and the three form a medicine boiling pot-filter-refrigeration tank combined system.

[0010] A first condenser 6 is arranged in the center of the top of the medicine boiling tank 1, a first compressed nitrogen inlet 7 is arranged on the left side of the top of the tank, a first feed inlet 8 is arranged on the right side of the top of the tank, a first steam heating valve 9 and a first refrigerant cooling valve 10 are arranged in the tank interlayer, a first temperature detector 11 is arranged on the inner wall of the tank body, a first stirring paddle 12 is arranged at the bottom of the tank body, and the first feed pipe 4 is controlled by a valve.

[0011] A second condenser 13 is arranged in the center of the top of the refrigerated tank 3, a second compressed nitrogen inlet 15 is arranged on the left side of the top of the tank, a second feed inlet 14 is arranged on the right side of the top of the tank, a second steam heating valve 16 and a second refrigerant cooling valve 17 are arranged in the tank interlayer, a second temperature detector 18 is arranged on the inner wall of the tank, a second stirring paddle 19 is arranged at the bottom of the tank, and the second feed pipe 5 is controlled by a valve.

[0012] In the present invention, the filter 2 has first detachable stainless steel sealing baffles 20 at both ends and a first detachable stainless steel filter card slot 21 inside; the first detachable stainless steel sealing baffle 20 of the filter 2 is a stainless steel circular plate with a thickness of 3-5 cm, and the first detachable stainless steel filter card slot 21 is a stainless steel ring with a thickness of 3-5 cm.

[0013] The bottom right side of the refrigerated tank 3 is provided with a discharging device 22 with filtering function, with second detachable stainless steel sealing baffles 23 at both ends and a second detachable stainless steel filter card slot 24 inside, which is connected to an electric pump 25.

[0014] In the present invention, the first condenser 6 and the second condenser 13 are internally composed of a spiral coil surrounding a hollow cylindrical pipe, and exhaust ports are provided at the top of the first condenser 6 and the second condenser 13. Cooling water at 4°C-15°C is passed into the spiral coil; the optimal temperature of the cooling water is 4°C.

[0015] The first compressed nitrogen inlet 7 of the present invention is composed of an opening with an opening end facing downward and forming an angle of 90° with the medicine boiling pot 1, and the second compressed nitrogen inlet 15 is composed of an opening with an opening end facing downward and forming an angle of 90° with the medicine boiling pot 3.

[0016] The steam inlet of the first steam heating valve 9 is located at the lower left end of the medicine boiling pot 1, and the steam outlet of the first steam heating valve 9 is located at the upper right end of the medicine boiling pot 1; the steam inlet of the second steam heating valve 16 is located at the lower left end of the refrigeration tank 3, and the steam outlet of the second steam heating valve 16 is located at the upper right end of the refrigeration tank 3.

[0017] The refrigerant inlet of the first refrigerant cooling valve 10 is located at the lower right end of the medicine boiling pot 1, and the refrigerant outlet of the first refrigerant cooling valve 10 is located at the upper left end of the tank body 1; the refrigerant inlet of the second refrigerant cooling valve 17 is located at the lower right end of the tank body 3, and the refrigerant outlet is located at the upper left end of the tank body 3.

[0018] During the design and improvement of a multifunctional Chinese medicine oral liquid refining combined system of the present invention, the inventor noticed that some medicine liquids contain volatile components. When using a conventional medicine boiling pot for medicine boiling operations, the volatile components will volatilize due to the increase in temperature, resulting in the loss of volatile components, thereby affecting the quality of the final product. Therefore, a first condenser 6 and a second condenser 13 are respectively arranged above the tank bodies of the medicine boiling pot 1 and the cold storage tank 3. During the heating process of the medicine liquid, the water will evaporate and rise above the tank body, and the volatile components in the medicine liquid will also rise with the water vapor. The water vapor containing volatile components will re-condense when encountering the condenser during the rising process and fall back into the medicine liquid in the tank, thereby achieving the purpose of protecting the volatile components in the medicine liquid from being lost due to heating.

[0019] Some Chinese medicine liquid contains heat-sensitive components, which will be decomposed or converted into other substances if the heating temperature is too high. Therefore, the present invention installs a first temperature detector 11 and a second temperature detector 18 at one-third of the distance from the bottom of the tank body of the medicine boiling tank 1 and the refrigeration tank 3 to timely detect the temperature of the medicine liquid. When the medicine liquid in the tank reaches the set temperature, an alarm can be issued to achieve precise temperature control, avoid the loss of the medicine liquid due to the destruction of some heat-sensitive components due to the excessively high heating temperature, and avoid the failure to achieve the ideal medicine boiling effect due to the excessively low heating temperature.

[0020] The present invention also designs a filtration system powered by compressed nitrogen for drugs containing photosensitive components and easily oxidized components, so as to keep the drug liquid from contacting air and natural light during the entire process of boiling, refrigerating and filtering, thereby protecting the relevant components in the drug liquid from being destroyed.

[0021] In addition, different liquid medicines have different fluidity and permeability due to the different ingredients they contain. Liquid medicines with high viscosity are relatively difficult to filter, while liquid medicines with low viscosity are filtered at a relatively fast speed, and the filter medium has a great influence on the filtering speed. After research, the inventor innovatively designed the filter 2 as a cylindrical structure with a first removable stainless steel sealing partition 20 at both ends and 5-10 layers of first removable stainless steel filter slots 21 in the middle. The number of slots can be selected according to the filtering needs, and the filter partition can be closed at any time during the filtering process to replace the filter medium. Specifically, the first removable stainless steel sealing partition 20 is a stainless steel circular plate with a thickness of 3-5cm, and the first removable stainless steel filter slot 21 is a stainless steel ring with a thickness of 3-5cm. The inner side can be embedded with a filter screen according to the filtering needs, or the filter paper can be cut to the corresponding size and fixed by the buckle on the first removable stainless steel filter slot 21. When the medicinal liquid needs to be filtered, the two ends of the filter 2 are connected to the first feed pipe 4 and the second feed pipe 5 respectively, and then the required filter screen or filter paper is installed in the first detachable stainless steel filter card slot 21. After confirming that the connection is correct and the connection is sealed, open the valves connecting the first feed pipe 4 and the second feed pipe 5, and open the valve of the first compressed nitrogen inlet 7 at the top of the medicine boiling tank 1, and the medicinal liquid can be filtered from the medicine boiling tank 1 to the refrigeration tank 3; when the medicinal liquid does not need to be filtered, the filter 2 can be used as a connecting pipe without installing a filter medium.

[0022] Specifically, during the cooking, filtering and refrigeration operations, first ensure that the valves of the first feed pipe 4 and the second feed pipe 5 are closed, then the liquid medicine is continuously introduced into the cooking tank 1 from the first feed port 8, and the first steam heating valve 9, the first condenser 6 on the top of the tank body and the first stirring paddle 12 are opened for stirring and heating. After the liquid medicine is heated to a certain temperature and kept warm for a period of time, the required filter material is placed in the first detachable stainless steel filter card slot 21 of the filter 2, and the card slot is fixed and installed. After ensuring that the system is sealed, the valves of the first feed pipe 4 and the second feed pipe 5 are opened, and the first detachable stainless steel sealing partitions 20 at both ends of the filter 2 are opened. At the same time, the valve of the first compressed nitrogen inlet 7 on the top of the cooking tank 1 is opened, and the liquid medicine is filtered through the filter 2 by means of the pressure difference between the cooking tank 1 and the refrigeration tank 3, and enters the refrigeration tank 3 for refrigeration.

[0023] After the liquid medicine in the medicine-cooking tank 1 completely enters the cold storage tank 3, close the first detachable stainless steel sealing partition 20 of the filter 2, close the valves of the first feeding pipe 4 and the second feeding pipe 5, open the second refrigerant cooling valve 17 of the cold storage tank 3, reduce the liquid medicine to a certain temperature, and seal and refrigerate. After the liquid medicine is refrigerated for a specified time, open the discharge device 22 on the right side of the bottom of the cold storage tank 3, install the second detachable stainless steel sealing partition 23, put the filter material into the second detachable stainless steel filter card slot 24, open the second compressed nitrogen inlet 15 valve on the top of the cold storage tank 3, introduce nitrogen, and start the electric pump 25 at the same time, input the liquid medicine from the cold storage tank 3 to the liquid medicine filling production line, so as to isolate the liquid medicine from the air during the filtering and refrigeration process, and protect the easily oxidized components in the liquid medicine from being destroyed.

[0024] Another application scenario of the present invention is as follows. If the capacity of the medicine boiling tank 1 is insufficient to accommodate all the medicine liquid and the medicine liquid does not need to be filtered, the medicine boiling tank 1 and the refrigeration tank 3 can be used simultaneously for medicine boiling and refrigeration operations, specifically: remove the first detachable stainless steel sealing baffles 20 at both ends of the filter 2, and use the filter 2 as a connecting pipe. Open the valves of the first feed pipe 4 and the second feed pipe 5 to keep the medicine boiling tank 1 and the refrigeration tank 3 connected, and continuously introduce the medicine liquid into the medicine boiling tank 1 and the refrigeration tank 3 from the first feed port 8 and the second feed port 14, open the first steam heating valve 9 and the second steam heating valve 16 respectively, start the first condenser 6 and the second condenser 13, and start boiling medicine. When the medicine liquid is heated and heated to the specified temperature and the insulation is completed, close the first steam heating valve 9 and the second steam heating valve 16, open the first refrigerant cooling valve 10 and the second refrigerant cooling valve 17, and start refrigeration. After the medicinal liquid is refrigerated for a specified time, the medicinal liquid is discharged from the discharge device 22 with a filtering function at the bottom of the refrigerating tank 3, and the filtering material is placed in the second detachable stainless steel filter card slot 24. The valves of the first compressed nitrogen gas inlet 7 and the second compressed nitrogen gas inlet 15 are opened to introduce nitrogen. At the same time, the electric pump 25 is turned on to draw the medicinal liquid from the medicine boiling tank 1 and the refrigerating tank 3 into the corresponding medicinal liquid preparation production line, so as to isolate the medicinal liquid from the air during the filtering and refrigeration process and protect the easily oxidized components in the medicinal liquid from being destroyed.

[0025] The multifunctional Chinese medicine refining combined system of the present invention keeps a medicine boiling tank, a refrigerating tank and a filter in detachable connection through a feeding pipe, and the three form a medicine boiling tank-filter-refrigerating tank combined system, which realizes the continuity of operations such as medicine boiling, filtering and refrigeration, reduces the loss of medicine liquid, reduces energy consumption, saves time and is highly efficient, and can prevent the loss and change of photosensitivity components, heat-sensitive components and volatile components, thereby improving the quality and stability of the preparation.

[0026] The present invention has novel design, reasonable structure, convenient operation, precise control, and can continuously operate the whole process of boiling, filtering and refrigerating, and has remarkable technical effects. Compared with the existing conventional boiling and refrigerating equipment, the present invention has the following substantial characteristics and progress:

[0027] 1. The multifunctional Chinese medicine oral liquid refining combined system of the present invention utilizes a feed pipe to connect the medicine boiling tank, filter and refrigeration tank in a closed manner, which can realize the four-in-one continuous operation of medicine boiling, filtering, refrigeration and transmission, reduce the loss of medicine liquid, save time and labor, and be energy-efficient and efficient.

[0028] 2. The improved medicine boiling tank, through the nitrogen booster device, condensation device and temperature control system, greatly reduces the loss and change of photosensitive components, heat-sensitive components and volatile components. It has the characteristics of precise temperature control, safety and environmental protection, and improves the intrinsic quality stability of the preparation.

[0029] 3. The present invention realizes the interchangeability and replacement of the refrigeration tank and the medicine boiling tank by technically transforming the interlayer of the conventional medicine boiling tank and the refrigeration tank. Without increasing the equipment investment, the production capacity of the Chinese medicine oral liquid refining system is greatly increased, the equipment utilization rate is improved, the system floor space is saved, and the equipment investment and construction cost are reduced.

[0030] 4. The combined system of the present invention can realize continuous feeding, boiling, filtering and refrigeration operations under full-speed operation conditions, which solves the disadvantages of high labor intensity, more on-site dirt, and easy secondary pollution of the production environment, reduces production costs, and is conducive to realizing automated production. In addition, the closed filtration system can reduce the safety hazards of operators and achieve the purpose of safe and efficient production. It has broad prospects for promotion and application. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to facilitate understanding and grasping the technical solution of the invention of this application, the following is a brief introduction to the drawings. It should be noted that the following drawings should not be regarded as limiting the scope of the technical solution. For ordinary technicians in this field, other relevant drawings can be obtained based on the following drawings without creative work.

[0032] Attached Figure 1 This is a schematic diagram of the structure of the multifunctional Chinese medicine oral liquid refining combination system

[0033] The markings in the attached drawings are described as follows: 1-cooking pot; 2-filter; 3-refrigeration tank; 4-first feed pipe; 5-second feed pipe; 6-first condenser; 7-first compressed nitrogen inlet; 8-first feed inlet; 9-first steam heating valve; 10-first refrigerant cooling valve; 11-first temperature detector; 12-first stirring paddle; 13-second condenser; 14-second feed inlet; 15-second compressed nitrogen inlet; 16-second steam heating valve; 17-second refrigerant cooling valve; 18-second temperature detector; 19-second stirring paddle; 20-first detachable stainless steel sealing baffle; 21-first detachable stainless steel filter card slot; 22-discharging device; 23-second detachable stainless steel sealing baffle; 24-second detachable stainless steel filter card slot; 25-electric pump. DETAILED DESCRIPTION

[0034] The specific embodiments of the present invention are further described in detail below in conjunction with the accompanying drawings.

[0035] In order to make the purpose, technical solutions and advantages of this application clearer and more explicit, the technical solutions in the embodiments will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the following embodiments are part of the embodiments of this application, but not all of them. Generally speaking, the components and connection methods described and shown in the accompanying drawings and the embodiments can be set and arranged in other ways, which are not listed here one by one due to limited space.

[0036] Therefore, the following detailed description of the embodiments does not limit the scope of protection claimed in the present application, and equivalent substitutions or modifications made by ordinary technicians in the field without making creative work should be included in the scope of protection of the present invention.

[0037] Example 1 Structure and operation mode of multifunctional Chinese medicine oral liquid refining combination system

[0038] As attached Figure 1 As shown, the high-efficiency extraction centrifugal device of the present invention is mainly composed of a medicine cooking tank 1, a filter 2, and a refrigeration tank 3. The medicine cooking tank 1 is detachably connected to the filter 2 through a first material delivery pipe 4. At the same time, the refrigeration tank 3 is detachably connected to the filter 2 through a second material delivery pipe 5. The three form a medicine cooking tank-filter-refrigeration tank combination system.

[0039] A first condenser 6 is arranged in the center of the top of the medicine boiling tank 1, a first compressed nitrogen inlet 7 is arranged on the left side of the top of the tank, a first feed inlet 8 is arranged on the right side of the top of the tank, a first steam heating valve 9 and a first refrigerant cooling valve 10 are arranged in the tank interlayer, a first temperature detector 11 is arranged on the inner wall of the tank body, a first stirring paddle 12 is arranged at the bottom of the tank body, and the first feed pipe 4 is controlled by a valve.

[0040] A second condenser 13 is arranged in the center of the top of the refrigerated tank 3, a second compressed nitrogen inlet 15 is arranged on the left side of the top of the tank, a second feed inlet 14 is arranged on the right side of the top of the tank, a second steam heating valve 16 and a second refrigerant cooling valve 17 are arranged in the tank interlayer, a second temperature detector 18 is arranged on the inner wall of the tank, a second stirring paddle 19 is arranged at the bottom of the tank, and the second feed pipe 5 is controlled by a valve.

[0041] During the decoction, filtration and refrigeration operation, first ensure that the valves of the first feed pipe 4 and the second feed pipe 5 are closed, then the liquid medicine is continuously introduced into the medicine-cooking tank 1 from the first feed port 8, and the first steam heating valve 9, the first condenser 6 on the top of the tank body and the first stirring paddle 12 are opened for stirring and heating. After the liquid medicine is heated to a certain temperature and kept warm for a period of time, the required filter material is placed in the first detachable stainless steel filter card slot 21 of the filter 2, and the card slot is fixed and installed. After ensuring the system is sealed, the valves of the first feed pipe 4 and the second feed pipe 5 are opened, and the first detachable stainless steel sealing partitions 20 at both ends of the filter 2 are opened. At the same time, the valve of the first compressed nitrogen inlet 7 on the top of the medicine-cooking tank 1 is opened, and the liquid medicine is filtered through the filter 2 by means of the pressure difference between the medicine-cooking tank 1 and the refrigerating tank 3, and enters the refrigerating tank 3 for refrigeration.

[0042] After the liquid medicine in the medicine-cooking tank 1 completely enters the cold storage tank 3, close the first detachable stainless steel sealing partition 20 of the filter 2, close the valves of the first feeding pipe 4 and the second feeding pipe 5, open the second refrigerant cooling valve 17 of the cold storage tank 3, reduce the liquid medicine to a certain temperature, and seal and refrigerate. After the liquid medicine is refrigerated for a specified time, open the discharge device 22 on the right side of the bottom of the cold storage tank 3, install the second detachable stainless steel sealing partition 23, put the filter material into the second detachable stainless steel filter card slot 24, open the second compressed nitrogen inlet 15 valve on the top of the cold storage tank 3, introduce nitrogen, and start the electric pump 25 at the same time, input the liquid medicine from the cold storage tank 3 to the liquid medicine filling production line, so as to isolate the liquid medicine from the air during the filtering and refrigeration process, and protect the easily oxidized components in the liquid medicine from being destroyed.

[0043] Embodiment 2 The multifunctional Chinese medicine oral liquid refining combined system is used as a medicine boiling pot alone

[0044] Another application scenario of the present invention is to use the medicine-boiling tank 1 and the refrigerating tank 3 to perform medicine-boiling and refrigerating operations at the same time, specifically: remove the first detachable stainless steel sealing baffles 20 at both ends of the filter 2, and use the filter 2 as a connecting pipe. Open the valves of the first feed pipe 4 and the second feed pipe 5 to keep the medicine-boiling tank 1 and the refrigerating tank 3 connected, and continuously introduce the medicine liquid into the medicine-boiling tank 1 and the refrigerating tank 3 from the first feed port 8 and the second feed port 15, open the first steam heating valve 9 and the second steam heating valve 16 respectively, start the first condenser 6 and the second condenser 13, and start boiling the medicine. When the medicine liquid is heated and heated to the specified temperature and the insulation is completed, close the first steam heating valve 9 and the second steam heating valve 16, open the first refrigerant cooling valve 10 and the second refrigerant cooling valve 17, and start refrigeration. After the medicinal liquid is refrigerated for a specified time, the medicinal liquid is discharged from the discharge device 22 with a filtering function at the bottom of the refrigerating tank 3, and the filtering material is placed in the second detachable stainless steel filter card slot 24. The valves of the first compressed nitrogen gas inlet 7 and the second compressed nitrogen gas inlet 15 are opened to introduce nitrogen. At the same time, the electric pump 25 is turned on to draw the medicinal liquid from the medicine boiling tank 1 and the refrigerating tank 3 into the corresponding medicinal liquid preparation production line, so as to isolate the medicinal liquid from the air during the filtering and refrigeration process and protect the easily oxidized components in the medicinal liquid from being destroyed.

[0045] Example 3: Process of preparing, boiling, filtering and refrigerating "Xintong Oral Liquid"

[0046] The preparation of "Xintong Oral Liquid" produced by Lunan Houpu Pharmaceutical Co., Ltd. was used as the research object to investigate the influence of the condenser and temperature detector parameter settings on the protection effect of drug ingredients. It should be noted that the preparation formula of "Xintong Oral Liquid" is relatively complex, and the types of active ingredients are diverse, including both photosensitive ingredients and volatile ingredients and heat-sensitive ingredients. The preparation, refrigeration and filtration tests of its preparation are quite representative. The test methods and results are as follows:

[0047] Take 173.3kg of Astragalus, 93.3kg of Codonopsis, 66.7kg of Ophiopogon, 53.3kg of Polygonum multiflorum, 53.3kg of Epimedium, 146.7kg of Pueraria, 53.3kg of Angelica, 100kg of Salvia, 53.3kg of Gleditsia, 93.3kg of Sargassum, 93.3kg of Kelp, 93.3kg of Oyster, 26.7kg of Citrus aurantium, add 70% ethanol to reflux twice, each time for 1 hour, combine the ethanol extracts, and set aside; decoct the residues and 11 other ingredients including Astragalus with water twice, the first time for 2 hours and the second time for 1.5 hours, filter, and concentrate the filtrate to a relatively dense The extract is mixed with an ethanol extract, and an appropriate amount of ethanol is added to make the alcohol content reach 65%. The extract is passed through cooling water and allowed to stand for precipitation for 24-48 hours. The extract is filtered, and the filtrate is used to recover the ethanol and concentrated to a relative density of 1.20-1.25 (70°C). An appropriate amount of purified water is added, the extract is refrigerated, filtered, and an appropriate amount of medicinal charcoal is added. The extract is boiled in the medicine boiling pot 1 of the multifunctional Chinese medicine oral liquid refining combined system of the present invention, and filtered by the filter 2. The extract is then heated in the refrigerating pot 3, kept warm, filtered, and precipitated for 24 hours. The extract is filtered to prepare the Xintong oral liquid. The changes of the target components in the Xintong oral liquid are compared. The results are shown in Tables 1 and 2.

[0048] Table 1 Effects of condensation and temperature control systems on target components in Xintong oral liquid

[0049]

[0050] It should be noted that the ferulic acid content in the Xintong oral liquid produced by conventional equipment and process is 0.294-0.319 mg / ml, which is afraid of light, easily oxidized, and easily decomposed by heating; the content of diphenylethylene glycoside in the Xintong oral liquid is 0.5708-0.5800 mg / mL.

[0051] As can be seen from Table 1, the contents of ferulic acid, diphenylethylene glycosides, and ligustilide in the Xintong oral liquid gradually decrease with the increase of heating temperature, and the decrease can be reduced by turning on the condenser. Ligustilide is a volatile component, and the condenser can make it condense into oil droplets and fall back into the liquid when it is cooled during the volatilization process, reducing the loss of components. Ferulic acid and diphenylethylene glycosides are easily decomposed and transformed when heated, and precise temperature control can reduce component loss and ensure the stability of the liquid quality before and after the boiling operation.

[0052] Table 2 Effect of compressed nitrogen gas flow rate on target components in Xintong oral liquid

[0053]

[0054] It can be seen from Table 2 that the high content of compressed nitrogen filling during the filtration process can keep the ferulic acid content at a high level and keep ligustilide in a relatively stable state.

[0055] According to the above test results, considering the actual situation of large-scale production in the workshop and the needs of energy saving and consumption reduction in the production process, the temperature of the refrigerant introduced into the condenser in the present invention is determined to be 4-15°C; preferably, the temperature of the refrigerant introduced is 4°C.

[0056] The above describes the basic principles and main features of the present invention, as well as the advantages of the present invention. Those skilled in the art should know that the above embodiments should not be regarded as limiting the present invention, and any improvements and changes made based on the principles of the present invention fall within the scope of the present invention claimed.

Claims

1. A multifunctional Chinese medicine oral liquid refining combined system, comprising a medicine boiling tank (1), a filter (2), and a refrigeration tank (3), characterized in that: The medicine-cooking tank (1) is detachably connected to the filter (2) via a first material delivery pipe (4), and the refrigerating tank (3) is detachably connected to the filter (2) via a second material delivery pipe (5), so that the three form a medicine-cooking tank-filter-refrigerating tank combined system; The medicine boiling tank (1) is provided with a first condenser (6) at the center of the tank top, a first compressed nitrogen inlet (7) is provided on the left side of the tank top, a first feed inlet (8) is provided on the right side of the tank top, a first steam heating valve (9) and a first refrigerant cooling valve (10) are provided in the tank interlayer, a first temperature detector (11) is provided on the inner wall of the tank body, a first stirring paddle (12) is provided at the bottom of the tank body, and a first feed pipe (4) is controlled by a valve; The refrigerated tank (3) is provided with a second condenser (13) at the center of the tank top, a second compressed nitrogen inlet (15) is provided on the left side of the tank top, a second feed inlet (14) is provided on the right side of the tank top, a second steam heating valve (16) and a second refrigerant cooling valve (17) are provided in the tank interlayer, a second temperature detector (18) is provided on the inner wall of the tank, a second stirring paddle (19) is provided at the bottom of the tank, and the second feed pipe (5) is controlled by a valve; The filter (2) has first detachable stainless steel sealing baffles (20) at both ends and a first detachable stainless steel filter card slot (21) inside; The bottom right side of the refrigerated tank (3) is provided with a discharging device (22) with filtering function, with second detachable stainless steel sealing baffles (23) at both ends and a second detachable stainless steel filter card slot (24) inside, and the second detachable stainless steel filter card slot (24) is connected to an electric pump (25).

2. The multifunctional Chinese medicine oral liquid refining combined system according to claim 1, characterized in that: The first detachable stainless steel sealing partition (20) of the filter (2) is a stainless steel circular plate with a thickness of 3-5 cm, and the first detachable stainless steel filter card slot (21) is a stainless steel circular ring with a thickness of 3-5 cm.

3. The multifunctional Chinese medicine oral liquid refining combined system according to claim 1, characterized in that: The first condenser (6) and the second condenser (13) are formed by spiral coils surrounding a hollow cylindrical pipe. The tops of the first condenser (6) and the second condenser (13) are both provided with exhaust ports, and cooling water at a temperature of 4°C to 15°C is passed into the spiral coils.

4. The multifunctional Chinese medicine oral liquid refining combined system according to claim 1, characterized in that: The temperature of the cooling water flowing into the spiral coils inside the first condenser (6) and the second condenser (13) is 4°C.

5. The multifunctional Chinese medicine oral liquid refining combined system according to claim 1, characterized in that: The first compressed nitrogen inlet (7) is composed of an opening with an opening end facing downwards and forming an angle of 90° with the medicine boiling tank (1), and the second compressed nitrogen inlet (15) is composed of an opening with an opening end facing downwards and forming an angle of 90° with the refrigeration tank (3).

6. The multifunctional Chinese medicine oral liquid refining combined system according to claim 1, characterized in that: The steam inlet of the first steam heating valve (9) is located at the lower left end of the medicine boiling tank (1), and the steam outlet of the first steam heating valve (9) is located at the upper right end of the medicine boiling tank (1); the steam inlet of the second steam heating valve (16) is located at the lower left end of the refrigeration tank (3), and the steam outlet of the second steam heating valve (16) is located at the upper right end of the refrigeration tank (3).

7. The multifunctional Chinese medicine oral liquid refining combined system according to claim 1, characterized in that: The refrigerant inlet of the first refrigerant cooling valve (10) is located at the lower right end of the medicine boiling tank (1), and the refrigerant outlet of the first refrigerant cooling valve (10) is located at the upper left end of the medicine boiling tank (1); the refrigerant inlet of the second refrigerant cooling valve (17) is located at the lower right end of the refrigeration tank (3), and the refrigerant outlet is located at the upper left end of the refrigeration tank (3).

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