Methods for diagnosis or prognosis of neurological disorders

Abstract

The present invention relates to a method for diagnosing or prognosing a neurological disorder in a subject. The method comprises determining the quantitative or qualitative level of one or more biomarkers in a biological sample from the subject; and diagnosing or prognosing the neurological disorder in the subject based on the quantitative or qualitative level of the or each biomarker in the biological sample.

Description

Technical Field

[0001] The present invention relates to a method for diagnosing or prognosing a neurological disorder in a subject. The method comprises determining the quantitative or qualitative level of one or more biomarkers in a biological sample from the subject; and diagnosing or prognosing the neurological disorder in the subject based on the quantitative or qualitative level of the or each biomarker in the biological sample. Background Art

[0002] Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal motor neuron disease caused by progressive degeneration and death of upper and lower motor neurons, protein aggregation, severe muscle atrophy, and respiratory insufficiency. The median survival is between 2 and 5 years from the onset of symptoms. ALS manifests as familial ALS (FALS; ~10% of cases) or sporadic ALS (SALS; ~90% of cases). The estimated incidence of ALS is between 0.3 and 2.6 cases per 100,000 people (2.16 / 100,000 person-years in Europe and 2.0 / 100,000 person-years in Ireland).

[0003] Studies in animal models and ALS patients suggest that motor neuron degeneration begins at the neuromuscular junction and that postsynaptic muscle changes may play an active role. Studies have shown that skeletal muscle has functional secretory activity. The muscle secretome contains exosomes—vesicles that carry out intercellular transport of functional proteins, mRNA, and miRNA. Exosomes can act in an autocrine / paracrine manner on muscle cells or other cell types and contribute to muscle growth and regeneration, systemic metabolism, and other functions.

[0004] Pathological aggregation of misfolded proteins, such as SOD1, TDP-43 or FUS proteins in affected neurons and adjacent glia can be considered a hallmark of ALS. Several recent studies have shown that these intracellular proteins can be released by vesicle-mediated exocytosis and then engulfed by neighboring cells, allowing them to be transmitted to adjacent motor neurons in a self-perpetuating manner. In addition, in familial ALS, mutations in genes involved in the autophagy pathway and multivesicle biogenesis (such as ALSIN, VAPB, CHMP2B and VCP) have been identified. Taken together, these data strongly suggest disruption of the endosomal and lysosomal pathways in patients with sporadic and familial ALS - both pathways are involved in exosome generation.

[0005] Diagnosis is slow, often requiring patients to see several specialists over several months: the average time from symptom onset to diagnosis is 13-18 months. Therefore, the problem / need is to diagnose ALS more quickly. Summary of the Invention

[0006] According to a first aspect of the present invention, there is provided a method for diagnosing or prognosing a neurological disorder in a subject, the method comprising the following steps:

[0007] (a) determining the quantitative or qualitative level of one or more biomarkers in a biological sample from a subject; and

[0008] (b) diagnosing or prognosing a neurological disorder in a subject based on the quantitative or qualitative level of the or each biomarker in the biological sample;

[0009] wherein the or each biomarker is selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; C0L5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; EEF1D; TPI1; SSBP1; PSMB8; PSAP; PSMB7; CAPZA1; PRDX1; PGDN; MMP1; NUCB2; HMGB1; AHNAK; FNDC1; DENR; PENK; S100A11; RPL29; RPL27; RPL8; SRSF2; SF3B4; SBSN; LYAR; NUDC; CRLF1; TGFB1; CAT; CTSD; DLD ;EPB41L2;PSMB9;RPS14;RPL7A;COLEC12;SMARCC2;TAGLN2;CCT4;ASPH;GPS1;CDK13;SH3GL2;HBA1;APEX1;PSMB5;TXN;AXL;RPS8;SET;RPS18;CFL1;DMKN;RPL22;RPL6;FKBP10;PAFAH1B1;S100A13;PSMA6;SERPINE1;CAPRIN1;SEPT7;VTN;ENPP2;NEO1;DKC1;CHI3L1;SK0R1;SSRP1;COL4A2;NME1;CFB;EIF2S3;DPYSL2;NUMA1;KTN1;CHID1;EFEMP1;YWHAZ;LDHB;SDCBP;TLN1;DES;APP;and DAG1.

[0010] Preferably, the or each biomarker is selected from: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; and CAPRIN1.

[0011] More preferably, the or each biomarker is selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; CAPRIN1; DES; APP; and DAG1.

[0012] More preferably, the or each biomarker is selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; DES; APP; and DAG1.

[0013] Optionally, determining step (a) comprises determining the quantitative or qualitative levels of two or more biomarkers in a biological sample from the subject.

[0014] More optionally, determining step (a) comprises determining the quantitative or qualitative levels of three, four, five, eight, ten, twenty, twenty-five, twenty-eight, thirty, forty, fifty, sixty, seventy, eighty, ninety, one hundred or more biomarkers in a biological sample from the subject.

[0015] Optionally, determining step (a) comprises determining the quantitative or qualitative levels of all biomarkers in a biological sample from the subject.

[0016] Optionally or additionally, determining step (a) comprises determining the quantitative or qualitative level of each biomarker in a biological sample from the subject.

[0017] Optionally, the or each biomarker is a gene. More optionally, the or each biomarker is a nucleic acid. More optionally, the or each biomarker is a deoxyribonucleic acid.

[0018] Optionally, the or each biomarker is a translation product of a gene.

[0019] Optionally, the or each biomarker is a translation product of a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; EEF1D; TPI1; SSBP1; PSMB8; PSAP; PSMB7; CAPZA1; PRDX1; PGDN; MMP1; NUCB2; HMGB1; AHNAK; FNDC1; DENR; PENK; S100A11; RPL29; RPL27; RPL8; SRSF2; SF3B4; SBSN; LYAR; NUDC; CRLF1; TGFB1; CAT; C TSD; DLD; EPB41L2; PSMB9; RPS14; RPL7A; COLEC12; SMARCC2; TAGLN2; CCT4; ASPH; GPS1; CDK13; SH3G L2; HBA1; APEX1; PSMB5; TXN; AXL; RPS8; SET; RPS18; CFL1; DMKN; RPL22; RPL6; FKBP10; PAFAH1B1; S1 00A13; PSMA6; SERPINE1; CAPRIN1; SEPT7; VTN; ENPP2; NEO1; DKC1; CHI3L1; SK0R1; SSRP1; COL4A2; N ME1; CFB; EIF2S3; DPYSL2; NUMA1; KTN1; CHID1; EFEMP1; YWHAZ; LDHB; SDCBP; TLN1; DES; APP; and DAG1.

[0020] Preferably, the or each biomarker is a translation product of a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; and CAPRIN1.

[0021] More preferably, the or each biomarker is a translation product of a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; CAPRIN1; DES; APP; and DAG1.

[0022] More preferably, the or each biomarker is a translation product of a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; DES; APP; and DAG1.

[0023] Optionally, the or each biomarker is RNA.

[0024] Optionally, the or each biomarker is a ribonucleic acid having a miRBase accession number selected from the group consisting of: MIMAT0000244; ENSG00000239126; MIMAT0016865; MIMAT0002813; MIMAT0004697; MIMAT0000245; MIMAT0000737; MIMAT0000088; MIMAT0000414; MIMAT0004955; MIMAT0000076; MIMAT0000067; MIMAT0018084; and MIMAT0004813.

[0025] Optionally, the or each biomarker is a ribonucleic acid having a nucleic acid sequence selected from any one or more of SEQ ID Nos 109-122.

[0026] Optionally, the or each biomarker is a protein. More optionally, the or each biomarker is a peptide. More optionally, the or each biomarker is a polypeptide.

[0027] Optionally, the or each biomarker is a protein encoded by a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; EEF1D; TPI1; SSBP1; PSMB8; PSAP; PSMB7; CAPZA1; PRDX1; PGDN; MMP1; NUCB2; HMGB1; AHNAK; FNDC1; DENR; PENK; S100A11; RPL29; RPL27; RPL8; SRSF2; SF3B4; SBSN; LYAR; NUDC; CRLF1; TGFB1; CAT; CTSD; DLD; EPB41L2; PSMB9; RPS14; RPL7A; COLEC12; SMARCC2; TAGLN2; CCT4; ASPH; GPS1; CDK13; SH3 GL2; HBA1; APEX1; PSMB5; TXN; AXL; RPS8; SET; RPS18; CFL1; DMKN; RPL22; RPL6; FKBP10; PAFAH1B1; S1 00A13; PSMA6; SERPINE1; CAPRIN1; SEPT7; VTN; ENPP2; NEO1; DKC1; CHI3L1; SKOR1; SSRP1; COL4A2; N ME1; CFB; EIF2S3; DPYSL2; NUMA1; KTN1; CHID1; EFEMP1; YWHAZ; LDHB; SDCBP; TLN1; DES; APP; and DAG1.

[0028] Preferably, the or each biomarker is a protein encoded by a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; and CAPRIN1.

[0029] More preferably, the or each biomarker is a protein encoded by a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; CAPRIN1; DES; APP; and DAG1.

[0030] More preferably, the or each biomarker is a protein encoded by a gene selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; DES; APP; and DAG1.

[0031] Optionally, the or each biomarker is a protein having a UniProtKB / Swiss-Prot accession number selected from: P30101; Q76M96; P11142; P07093; Q15149; P11021; P19338; P09493; P24821; P17936; P20908; Q9Y240; P46821; Q13765; P25787; P46777; P60660; P07858; P10809; Q6NZI2; Q02818; P13667; P07237; 043707; P29692; P60174; Q04837; P28062; P07602; Q99436; P52907; Q06830; Q7Z5L7; P03956; P80303; P09429; Q09666; Q4ZHG4; 043583; P01210; P31949; P47914; P61353; P62917; Q01130; Q15427; Q6UWP8; Q9NX58; Q9Y266; 075462; P01137; P04040; P07339; P09622; 043491; P28065; P62263; P62424; Q5KU26; Q8TAQ2; P37802; P50991; Q12797; Q13098; Q14004; Q99962; P69905; P27695; P28074; P10599; P30530; P62241; Q01105; P62269; P23528; Q6E0U4; P35268; Q02878; Q96AY3; P43034; Q99584; P60900; P05121; Q14444; Q16181; P04004; Q13822; Q92859; 060832; P36222; P84550; Q08945; P08572; P15531; P00751; P41091; Q16555; Q14980; Q86UP2; Q9BWS9; Q12805; P63104; P07195; 000560; Q9Y490; P17661; P05067; and Q14118.

[0032] Preferably, the or each biomarker is a protein having a UniProtKB / Swiss-Prot accession number selected from the group consisting of: P30101; Q76M96; P11142; P07093; Q15149; P11021; P19338; P09493; P24821; P17936; P20908; Q9Y240; P46821; Q13765; P25787; P46777; P60660; P07858; P10809; Q6NZI2; Q02818; P13667; P07237; 043707; and Q14444.

[0033] More preferably, the or each biomarker is a protein having a UniProtKB / Swiss-Prot accession number selected from the group consisting of: P30101; Q76M96; P11142; P07093; Q15149; P11021; P19338; P09493; P24821; P17936; P20908; Q9Y240; P46821; Q13765; P25787; P46777; P60660; P07858; P10809; Q6NZI2; Q02818; P13667; P07237; 043707; Q14444; P17661; P05067; and Q14118.

[0034] More preferably, the or each biomarker is a protein having a UniProtKB / Swiss-Prot accession number selected from the group consisting of: P30101; Q76M96; P11142; P07093; Q15149; P17661; P05067; and Q14118.

[0035] Optionally, the or each biomarker is a protein having an amino acid sequence selected from any one or more of SEQ ID Nos 1-108.

[0036] Optionally, the neurological disorder is a neurodegenerative disorder.

[0037] Optionally, the neurodegenerative disorder is selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA) and spinal muscular atrophy.

[0038] Optionally, the diagnostic or prognostic step (b) comprises comparing the quantitative or qualitative level of the or each biomarker in the biological sample from the subject with the quantitative or qualitative level of the or each corresponding biomarker in a normal sample.

[0039] Optionally, the normal sample is a biological sample from a subject not suffering from a neurological disorder, optionally a neurodegenerative disorder, more optionally a neurodegenerative disorder selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA) and spinal muscular atrophy.

[0040] Optionally, a quantitative or qualitative level of the or each biomarker in a biological sample from a subject that is greater than the quantitative or qualitative level of the or each corresponding biomarker in a normal sample is indicative of a neurological disorder, optionally a neurodegenerative disorder, more optionally selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA), and the quantitative or qualitative level of a neurodegenerative disorder of spinal muscular atrophy.

[0041] Optionally, a quantitative or qualitative level of the or each biomarker in a biological sample from a subject that is greater than the quantitative or qualitative level of the or each corresponding biomarker in a normal sample indicates the quantitative or qualitative presence of a neurological disorder, optionally a neurodegenerative disorder, more optionally selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA), and spinal muscular atrophy.

[0042] Optionally, determining step (a) comprises determining the quantitative or qualitative levels of one or more subsets of the one or more biomarkers in a biological sample from the subject.

[0043] Optionally, determining step (a) comprises determining the quantitative or qualitative levels of two or more subsets of one or more biomarkers in a biological sample from the subject.

[0044] Optionally, determining step (a) comprises determining the quantitative or qualitative levels of three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen or fourteen subsets of one or more biomarkers in a biological sample from the subject.

[0045] Optionally, determining step (a) comprises determining the quantitative or qualitative level of one or more of a first, second, third, fourth, fifth, sixth, seventh, eighth, ninth, tenth, eleventh, twelfth, thirteenth, or fourteenth subset of one or more biomarkers in a biological sample from the subject.

[0046] Optionally, the first subset includes one or more biomarkers selected from the group consisting of: PDIA3; and CCDC80.

[0047] Optionally, the second subset comprises HSPA8.

[0048] Optionally, the third subset includes one or more biomarkers selected from: SERPINE2; and PLEC.

[0049] Optionally, the fourth subset includes one or more biomarkers selected from: HSPA5; and NCL.

[0050] Optionally, the fifth subset includes one or more biomarkers selected from the group consisting of: TPM1; and TNC.

[0051] Optionally, the sixth subset comprises IGFBP3.

[0052] Optionally, the seventh subset includes one or more biomarkers selected from the group consisting of: COL5A1; CLEC11A; MAP1B; NACA; and PSMA2.

[0053] Optionally, the eighth subset includes one or more biomarkers selected from the group consisting of: RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; and ACTN4.

[0054] Optionally, the ninth subset includes one or more biomarkers selected from the group consisting of: EEF1D; TPI1; SSBP1; PSMB8; PSAP; PSMB7; CAPZA1; PRDX1; PGDN; MMP1; NUCB2; HMGB1; AHNAK; and FNDC1.

[0055] Optionally, the tenth subset includes one or more biomarkers selected from the group consisting of DENR; PENK; S100A11; RPL29; RPL27; RPL8; SRSF2; SF3B4; SBSN; LYAR; NUDC; CRLF1; TGFB1; CAT; CTSD; DLD; EPB41L2; PSMB9; RPS14; RPL7A; COLEC12; SMARCC2; TAGLN2; CCT4; ASPH; GPS1; CDK13; SH3GL2; HBA1; APEX1; PSMB5; TXN ;AXL;RPS8;SET;RPS18;CFL1;DMKN;RPL22;RPL6;FKBP10;PAFAH1B1;S100A13;PSMA6;SERPINE1;CAPRIN1;SEPT7;VTN;ENPP2;N EO1; DKC1; CHI3L1; SKOR1; SSRP1; COL4A2; NME1; CFB; EIF2S3; DPYSL2; NUMA1; KTN1; CHID1; EFEMP1; YWHAZ; LDHB; SDCBP; and TLN1.

[0056] Optionally, the eleventh subset comprises one or more biomarkers selected from the group consisting of: DES; APP; and DAG1.

[0057] Optionally, the twelfth subset includes one or more biomarkers selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; and CAPRIN1.

[0058] Optionally, the thirteenth subset includes one or more biomarkers selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; HSPA5; NCL; TPM1; TNC; IGFBP3; COL5A1; CLEC11A; MAP1B; NACA; PSMA2; RPL5; MYL6; CTSB; HSPD1; PTRF; NUCB1; PDIA4; P4HB; ACTN4; CAPRIN1; DES; APP; and DAG1.

[0059] Optionally, the fourteenth subset includes one or more biomarkers selected from the group consisting of: PDIA3; CCDC80; HSPA8; SERPINE2; PLEC; DES; APP; and DAG1.

[0060] Optionally, determining step (a) comprises determining the quantitative or qualitative levels of all biomarkers in one or more of the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth, tenth, eleventh, twelfth, thirteenth or fourteenth subsets.

[0061] Optionally, determining step (a) comprises determining the quantitative or qualitative level of each biomarker in one or more of the first, second, third, fourth, fifth, sixth, seventh, eighth, ninth, tenth, eleventh, twelfth, thirteenth or fourteenth subsets.

[0062] Optionally, the diagnostic or prognostic step (b) comprises comparing the quantitative or qualitative level of the or each biomarker in the or each subset in a biological sample from the subject with the quantitative or qualitative level of the or each corresponding biomarker in a normal sample.

[0063] Optionally, the normal sample is a biological sample from a subject not suffering from a neurological disorder, optionally a neurodegenerative disorder, more optionally a neurodegenerative disorder selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA) and spinal muscular atrophy.

[0064] Optionally, a quantitative or qualitative level of the or each biomarker in the or each subset in a biological sample from a subject that is greater than the quantitative or qualitative level of the or each corresponding biomarker in a normal sample is indicative of a neurological disorder, optionally a neurodegenerative disorder, more optionally selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA), and the quantitative or qualitative level of a neurodegenerative disorder selected from the group consisting of amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA), and spinal muscular atrophy.

[0065] Optionally, a quantitative or qualitative level of the or each biomarker in the or each subset in a biological sample from a subject that is greater than the quantitative or qualitative level of the or each corresponding biomarker in a normal sample indicates the quantitative or qualitative presence of a neurological disorder, optionally a neurodegenerative disorder, more optionally selected from amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease; motor neuron disease; MND), hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP), pseudobulbar palsy, spinal bulbar muscular atrophy (SBMA) and spinal muscular atrophy.

[0066] Optionally or additionally, determining step (a) further comprises the further step of determining the quantitative or qualitative level of one or more biomarkers in a biological sample from the subject, wherein the or each biomarker is a ribonucleic acid having a miRBase accession number selected from the group consisting of: MIMAT0000244; ENSG00000239126; MIMAT0016865; MIMAT0002813; MIMAT0004697; MIMAT0000245; MIMAT0000737; MIMAT0000088; MIMAT0000414; MIMAT0004955; MIMAT0000076; MIMAT0000067; MIMAT0018084; and MIMAT0004813.

[0067] Optionally, the biological sample is selected from the group consisting of whole blood, serum, plasma, urine, interstitial fluid, peritoneal fluid, cervical swab, tears, saliva, buccal swab, skin, brain tissue, and cerebrospinal fluid.

[0068] More optionally, the biological sample is selected from the group consisting of whole blood, serum, and plasma.

[0069] More optionally, the biological sample is whole blood.

[0070] PDIA3 and Erp57 are synonymous. Sequence Listing <110> University of Ulster <120> Methods for diagnosing or prognosing a neurological disorder in a subject <130> P122497PC00 <150> GB1807178.7 <151> 2018-05-01 <160> 122 <170> PatentIn version 3.5 <210> 1 <211> 505 <212> PRT <213> Homo sapiens <400> 1 Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 1 5 10 15 Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 20 25 30 Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 35 40 45 Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 50 55 60 Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 65 70 75 80 Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 85​​​​​​​​​​​130 135 140 Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 145 150 155 160 Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 165 170 175 Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 180 185 190 Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 195 200 205 Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 210 215 220 Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 225 230 235 240 Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 245 250 255 Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 260 265 270 Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 275 280 285 Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 290 295 300 Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 305 310 315 320 Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 325 330 335 Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 340 345 350 Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 355 360 365 Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 370 375 380 Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 385 390 395 400 Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 405 410 415 Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 420 425 430 Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 435 440 445 Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 450 455 460 Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 465 470 475 480 Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 485 490 495 Lys Lys Lys Lys Ala Gln Glu Asp Leu 500 505 <210> 2 <211> 950 <212> PRT <213> Homo sapiens <400> 2 Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 1 5 10 15 Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 20 25 30 His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 35 40 45 Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 50 55 60 Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 65 70 75 80 Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 85 90 95 Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 100 105 110 Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 115 120 125 Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 130 135 140 Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 145 150 155 160 Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 165 170 175 Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 180 185 190 Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 195 200 205 Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 210 215 220 Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 225 230 235 240 Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 245 250 255 Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 260 265 270 Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 275 280 285 Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 290 295 300 Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 305 310 315 320 Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 325 330 335 Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 340 345 350 Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 355 360 365 Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 370 375 380 Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 385 390 395 400 Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 405 410 415 Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 420 425 430 Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 435 440 445 Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 450 455 460 Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 465 470 475 480 Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 485 490 495 Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 500 505 510 Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 515 520 525 Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 530 535 540 Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 545 550 555 560 Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 565 570 575 Light Gln Glu Light Glu Light Ser Light Light Light Light Gly Gly Light Thr Glu 580 585 590 Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 595 600 605 Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 610 615 620 Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 625 630 635 640 Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 645 650 655 Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 660 665 670 Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 675 680 685 Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 690 695 700 Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 705 710 715 720 Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 725 730 735 Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 740 745 750 Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 755 760 765 Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 770 775 780 Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 785 790 795 800 Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 805 810 815 Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 820 825 830 Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 835 840 845 Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 850 855 860 Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 865 870 875 880 Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 885 890 895 Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 900 905 910 Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 915 920 925 Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 930 935 940 His His Gly Tyr Pro Tyr 945 950 <210> 3 <211> 646 <212> PRT <213> Homo sapiens <400> 3 Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 1 5 10 15 Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 20 25 30 Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 35 40 45 Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 50 55 60 Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 65 70 75 80 Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 85 90 95 Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 100 105 110 Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 115 120 125 Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 130 135 140 Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 145 150 155 160 Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 165 170 175 Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 180 185 190 Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 195 200 205 Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 210 215 220 Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 225 230 235 240 Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 245 250 255 Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 260 265 270 Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 275 280 285 Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 290 295 300 Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 305 310 315 320 Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 325 330 335 Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 340 345 350 Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 355 360 365 Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 370 375 380 Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 385 390 395 400 Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 405 410 415 Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 420 425 430 Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 435 440 445 Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 450 455 460 Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 465 470 475 480 Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 485 490 495 Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 500 505 510 Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 515 520 525 Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 530 535 540 Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 545 550 555 560 Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 565 570 575 Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 580 585 590 Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 595 600 605 Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 610 615 620 Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 625 630 635 640 Thr Ile Glu Glu Val Asp 645 <210> 4 <211> 398 <212> PRT <213> Homo sapiens <400> 4 Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro 1 5 10 15 Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser 20 25 30 Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His 35 40 45 Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met 50 55 60 Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val 65 70 75 80 Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn 85 90 95 Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn 100 105 110 Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr 115 120 125 Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu 130 135 140 Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu 145 150 155 160 Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly 165 170 175 Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu 180 185 190 Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val 195 200 205 Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser 210 215 220 Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn 225 230 235 240 Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala 245 250 255 Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile 260 265 270 Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg 275 280 285 Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu 290 295 300 Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser 305 310 315 320 Lys Ala Asn Phe Ala Lys Ile Thr Thr Gly Ser Glu Asn Leu His Val 325 330 335 Ser His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr 340 345 350 Lys Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro 355 360 365 Pro Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn 370 375 380 Pro Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro 385 390 395 <210> 5 <211> 4684 <212> PRT <213> Homo sapiens <400> 5 Met Val Ala Gly Met Leu Met Pro Arg Asp Gln Leu Arg Ala Ile Tyr 1 5 10 15 Glu Val Leu Phe Arg Glu Gly Val Met Val Ala Lys Lys Asp Arg Arg 20 25 30 Pro Arg Ser Leu His Pro His Val Pro Gly Val Thr Asn Leu Gln Val 35 40 45 Met Arg Ala Met Ala Ser Leu Arg Ala Arg Gly Leu Val Arg Glu Thr 50 55 60 Phe Ala Trp Cys His Phe Tyr Trp Tyr Leu Thr Asn Glu Gly Ile Ala 65 70 75 80 His Leu Arg Gln Tyr Leu His Leu Pro Pro Glu Ile Val Pro Ala Ser 85 90 95 Leu Gln Arg Val Arg Arg Pro Val Ala Met Val Met Pro Ala Arg Arg 100 105 110 Thr Pro His Val Gln Ala Val Gln Gly Pro Leu Gly Ser Pro Pro Lys 115 120 125 Arg Gly Pro Leu Pro Thr Glu Glu Gln Arg Val Tyr Arg Arg Lys Glu 130 135 140 Leu Glu Glu Val Ser Pro Glu Thr Pro Val Val Pro Ala Thr Thr Gln 145 150 155 160 Arg Thr Leu Ala Arg Pro Gly Pro Glu Pro Ala Pro Ala Thr Asp Glu 165 170 175 Arg Asp Arg Val Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His 180 185 190 Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu Arg 195 200 205 Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Ser 210 215 220 Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn Val 225 230 235 240 Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val Asn 245 250 255 Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu Gly 260 265 270 Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln Val 275 280 285 Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu Trp 290 295 300 Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn Phe 305 310 315 320 Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His Arg 325 330 335 His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr Asn 340 345 350 Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu Gly 355 360 365 Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro Asp 370 375 380 Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met Pro 385 390 395 400 Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln Leu 405 410 415 Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp Met 420 425 430 Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser Phe 435 440 445 Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu Met 450 455 460 Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile Tyr 465 470 475 480 Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro Pro 485 490 495 Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His Val 500 505 510 Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg Leu 515 520 525 Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly Leu 530 535 540 Cys Glu Glu Gln Leu Asn Gln Ala Asp Ala Leu Leu Gln Ser Asp Val 545 550 555 560 Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val Glu 565 570 575 Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn Asp 580 585 590 Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met Tyr 595 600 605 Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr Glu 610 615 620 Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln Val 625 630 635 640 Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu Asp 645 650 655 Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu Asn 660 665 670 Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser Val 675 680 685 Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu Glu 690 695 700 Phe Arg Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu Ser 705 710 715 720 Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp Leu 725 730 735 Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser Leu 740 745 750 Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met Trp 755 760 765 Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp Arg 770 775 780 Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met Arg 785 790 795 800 Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala Gly 805 810 815 Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu Ser 820 825 830 Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu Cys 835 840 845 Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe 850 855 860 Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln Glu 865 870 875 880 Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr Arg 885 890 895 Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu Asn 900 905 910 Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala Val 915 920 925 Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg Leu 930 935 940 Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val His 945 950 955 960 Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His Trp 965 970 975 Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val Cys 980 985 990 Phe Leu Val Pro Pro Pro Asn Gln Glu Ala Gln Glu Ala Val Thr Arg 995 1000 1005 Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu 1010 1015 1020 His Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg 1025 1030 1035 Asp Val Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr 1040 1045 1050 Leu Lys Pro Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu 1055 1060 1065 His Tyr Gln Ala Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe 1070 1075 1080 Gly Pro Glu Asp Arg Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys 1085 1090 1095 Ser His His Tyr Gln Gln Leu Leu Gln Ser Leu Glu Gln Gly Ala 1100 1105 1110 Gln Glu Glu Ser Arg Cys Gln Arg Cys Ile Ser Glu Leu Lys Asp 1115 1120 1125 Ile Arg Leu Gln Leu Glu Ala Cys Glu Thr Arg Thr Val His Arg 1130 1135 1140 Leu Arg Leu Pro Leu Asp Lys Glu Pro Ala Arg Glu Cys Ala Gln 1145 1150 1155 Arg Ile Ala Glu Gln Gln Lys Ala Gln Ala Glu Val Glu Gly Leu 1160 1165 1170 Gly Lys Gly Val Ala Arg Leu Ser Ala Glu Ala Glu Lys Val Leu 1175 1180 1185 Path Leu Pro Glu Pro Ser Pro Path Path Pro Thr Leu Arg Ser Glu 1190 1195 1200 Leu Glu Leu Thr Leu Gly Lys Leu Glu Gln Val Arg Ser Leu Ser 1205 1210 1215 Ala Ile Tyr Leu Glu Lys Leu Lys Thr Ile Ser Leu Val Ile Arg 1220 1225 1230 Gly Thr Gln Gly Ala Glu Glu Val Leu Arg Ala His Glu Glu Gln 1235 1240 1245 Leu Lys Glu Path Gln Path Val Pro Path Thr Leu Pro Glu Leu Glu 1250 1255 1260 Path Thr Lys Path Ser Leu Lys Lys Leu Arg Path Gln Path Glu Path 1265 1270 1275 Gln Gln Pro Thr Phe Asp Ala Leu Arg Asp Glu Leu Arg Gly Ala 1280 1285 1290 Gln Glu Val Gly Glu Arg Leu Gln Gln Arg His Gly Glu Arg Asp 1295 1300 1305 Val Glu Val Glu Arg Trp Arg Glu Arg Val Ala Gln Leu Leu Glu 1310 1315 1320 Arg Trp Gln Ala Val Leu Ala Gln Thr Asp Val Arg Gln Arg Glu 1325 1330 1335 Leu Glu Gln Leu Gly Arg Gln Leu Arg Tyr Tyr Arg Glu Ser Ala 1340 1345 1350 Asp Pro Leu Gly Ala Trp Leu Gln Asp Ala Arg Arg Arg Gln Glu 1355 1360 1365 Gln Ile Gln Ala Met Pro Leu Ala Asp Ser Gln Ala Val Arg Glu 1370 1375 1380 Gln Leu Arg Gln Glu Gln Ala Leu Leu Glu Glu Ile Glu Arg His 1385 1390 1395 Gly Glu Lys Val Glu Glu Cys Gln Arg Phe Ala Lys Gln Tyr Ile 1400 1405 1410 Asn Ala Ile Lys Asp Tyr Glu Leu Gln Leu Val Thr Tyr Lys Ala 1415 1420 1425 Gln Leu Glu Pro Val Ala Ser Pro Ala Lys Lys Pro Lys Val Gln 1430 1435 1440 Ser Gly Ser Glu Ser Val Ile Gln Glu Tyr Val Asp Leu Arg Thr 1445 1450 1455 His Tyr Ser Glu Leu Thr Thr Leu Thr Ser Gln Tyr Ile Lys Phe 1460 1465 1470 Ile Ser Glu Thr Leu Arg Arg Met Glu Glu Glu Glu Arg Leu Ala 1475 1480 1485 Glu Gln Gln Arg Ala Glu Glu Arg Glu Arg Leu Ala Glu Val Glu 1490 1495 1500 Ala Ala Leu Glu Lys Gln Arg Gln Leu Ala Glu Ala His Ala Gln 1505 1510 1515 Ala Lys Ala Gln Ala Glu Arg Glu Ala Lys Glu Leu Gln Gln Arg 1520 1525 1530 Met Gln Glu Glu Val Val Arg Arg Glu Glu Ala Ala Val Asp Ala 1535 1540 1545 Gln Gln Gln Lys Arg Ser Ile Gln Glu Glu Leu Gln Gln Leu Arg 1550 1555 1560 Gln Ser Ser Glu Ala Glu Ile Gln Ala Lys Ala Arg Gln Ala Glu 1565 1570 1575 Ala Ala Glu Arg Ser Arg Leu Arg Ile Glu Glu Glu Ile Arg Val 1580 1585 1590 Val Arg Leu Gln Leu Glu Ala Thr Glu Arg Gln Arg Gly Gly Ala 1595 1600 1605 Glu Gly Glu Leu Gln Ala Leu Arg Ala Arg Ala Glu Glu Ala Glu 1610 1615 1620 Ala Gln Lys Arg Gln Ala Gln Glu Glu Ala Glu Arg Leu Arg Arg 1625 1630 1635 Gln Val Gln Asp Glu Ser Gln Arg Lys Arg Gln Ala Glu Val Glu 1640 1645 1650 Leu Ala Ser Arg Val Lys Ala Glu Ala Glu Ala Ala Arg Glu Lys 1655 1660 1665 Gln Arg Ala Leu Gln Ala Leu Glu Glu Leu Arg Leu Gln Ala Glu 1670 1675 1680 Glu Ala Glu Arg Arg Leu Arg Gln Ala Glu Val Glu Arg Ala Arg 1685 1690 1695 Gln Val Gln Val Ala Leu Glu Thr Ala Gln Arg Ser Ala Glu Ala 1700 1705 1710 Glu Leu Gln Ser Lys Arg Ala Ser Phe Ala Glu Lys Thr Ala Gln 1715 1720 1725 Leu Glu Arg Ser Leu Gln Glu Glu His Val Ala Val Ala Gln Leu 1730 1735 1740 Arg Glu Glu Ala Glu Arg Arg Ala Gln Gln Gln Ala Glu Ala Glu 1745 1750 1755 Arg Ala Arg Glu Glu Ala Glu Arg Glu Leu Glu Arg Trp Gln Leu 1760 1765 1770 Lys Ala Asn Glu Ala Leu Arg Leu Arg Leu Gln Ala Glu Glu Val 1775 1780 1785 Ala Gln Gln Lys Ser Leu Ala Gln Ala Glu Ala Glu Lys Gln Lys 1790 1795 1800 Glu Glu Ala Glu Arg Glu Ala Arg Arg Arg Gly Lys Ala Glu Glu 1805 1810 1815 Gln Ala Val Arg Gln Arg Glu Leu Ala Glu Gln Glu Leu Glu Lys 1820 1825 1830 Gln Arg Gln Leu Ala Glu Gly Thr Ala Gln Gln Arg Leu Ala Ala 1835 1840 1845 Glu Gln Glu Leu Ile Arg Leu Arg Ala Glu Thr Glu Gln Gly Glu 1850 1855 1860 Gln Gln Arg Gln Leu Leu Glu Glu Glu Leu Ala Arg Leu Gln Arg 1865 1870 1875 Glu Ala Ala Ala Ala Thr Gln Lys Arg Gln Glu Leu Glu Ala Glu 1880 1885 1890 Leu Ala Lys Val Arg Ala Glu Met Glu Val Leu Leu Ala Ser Lys 1895 1900 1905 Ala Arg Ala Glu Glu Glu Ser Arg Ser Thr Ser Glu Lys Ser Lys 1910 1915 1920 Gln Arg Leu Glu Ala Glu Ala Gly Arg Phe Arg Glu Leu Ala Glu 1925 1930 1935 Glu Ala Ala Arg Leu Arg Ala Leu Ala Glu Glu Ala Lys Arg Gln 1940 1945 1950 Arg Gln Leu Ala Glu Glu Asp Ala Ala Arg Gln Arg Ala Glu Ala 1955 1960 1965 Glu Arg Val Leu Ala Glu Lys Leu Ala Ala Ile Gly Glu Ala Thr 1970 1975 1980 Arg Leu Lys Thr Glu Ala Glu Ile Ala Leu Lys Glu Lys Glu Ala 1985 1990 1995 Glu Asn Glu Arg Leu Arg Arg Leu Ala Glu Asp Glu Ala Phe Gln 2000 2005 2010 Arg Arg Arg Leu Glu Glu Gln Ala Ala Gln His Lys Ala Asp Ile 2015 2020 2025 Glu Glu Arg Leu Ala Gln Leu Arg Lys Ala Ser Asp Ser Glu Leu 2030 2035 2040 Glu Arg Gln Lys Gly Leu Val Glu Asp Thr Leu Arg Gln Arg Arg 2045 2050 2055 Gln Val Glu Glu Glu Ile Leu Ala Leu Lys Ala Ser Phe Glu Lys 2060 2065 2070 Ala Ala Ala Gly Lys Ala Glu Leu Glu Leu Glu Leu Gly Arg Ile 2075 2080 2085 Arg Ser Asn Ala Glu Asp Thr Leu Arg Ser Lys Glu Gln Ala Glu 2090 2095 2100 Leu Glu Ala Ala Arg Gln Arg Gln Leu Ala Ala Glu Glu Glu Arg 2105 2110 2115 Arg Arg Arg Glu Ala Glu Glu Arg Val Gln Lys Ser Leu Ala Ala 2120 2125 2130 Glu Glu Glu Path Path Arg Gln Arg Lys Path Path Leu Glu Glu Val 2135 2140 2145 Glu Arg Leu Lys Ala Lys Val Glu Glu Ala Arg Arg Leu Arg Glu 2150 2155 2160 Arg Path Glu Gln Glu Ser Path Arg Gln Leu Gln Leu Path Gln Glu 2165 2170 2175 Ala Ala Gln Lys Arg Leu Gln Ala Glu Glu Lys Ala His Ala Phe 2180 2185 2190 Pathway Val Gln Gln Lys Glu Gln Glu Leu Gln Gln Thr Leu Gln Gln 2195 2200 2205 Glu Gln Ser Val Leu Asp Gln Leu Arg Gly Glu Ala Glu Ala Ala 2210 2215 2220 Arg Arg Ala Ala Glu Glu Ala Glu Glu Ala Arg Val Gln Ala Glu 2225 2230 2235 Arg Glu Ala Ala Gln Ser Arg Arg Gln Val Glu Glu Ala Glu Arg 2240 2245 2250 Leu Lys Gln Ser Ala Glu Glu Gln Ala Gln Ala Arg Ala Gln Ala 2255 2260 2265 Gln Ala Ala Ala Glu Lys Leu Arg Lys Glu Ala Glu Gln Glu Ala 2270 2275 2280 Ala Arg Arg Ala Gln Ala Glu Gln Ala Ala Leu Arg Gln Lys Gln 2285 2290 2295 Ala Ala Asp Ala Glu Met Glu Lys His Lys Lys Phe Ala Glu Gln 2300 2305 2310 Thr Leu Arg Gln Lys Ala Gln Val Glu Gln Glu Leu Thr Thr Leu 2315 2320 2325 Arg Leu Gln Leu Glu Glu Thr Asp His Gln Lys Asn Leu Leu Asp 2330 2335 2340 Glu Glu Leu Gln Arg Leu Lys Ala Glu Ala Thr Glu Ala Ala Arg 2345 2350 2355 Gln Arg Ser Gln Val Glu Glu Glu Leu Phe Ser Val Arg Val Gln 2360 2365 2370 Met Glu Glu Leu Ser Lys Leu Lys Ala Arg Ile Glu Ala Glu Asn 2375 2380 2385 Arg Ala Leu Ile Leu Arg Asp Lys Asp Asn Thr Gln Arg Phe Leu 2390 2395 2400 Gln Glu Glu Ala Glu Lys Met Lys Gln Val Ala Glu Glu Ala Ala 2405 2410 2415 Arg Leu Ser Val Ala Ala Gln Glu Ala Ala Arg Leu Arg Gln Leu 2420 2425 2430 Ala Glu Glu Asp Leu Ala Gln Gln Arg Ala Leu Ala Glu Lys Met 2435 2440 2445 Leu Lys Glu Lys Met Gln Ala Val Gln Glu Ala Thr Arg Leu Lys 2450 2455 2460 Ala Glu Ala Glu Leu Leu Gln Gln Gln Lys Glu Leu Ala Gln Glu 2465 2470 2475 Gln Ala Arg Arg Leu Gln Glu Asp Lys Glu Gln Met Ala Gln Gln 2480 2485 2490 Leu Ala Glu Glu Thr Gln Gly Phe Gln Arg Thr Leu Glu Ala Glu 2495 2500 2505 Arg Gln Arg Gln Leu Glu Met Ser Ala Glu Ala Glu Arg Leu Lys 2510 2515 2520 Leu Arg Val Ala Glu Met Ser Arg Ala Gln Ala Arg Ala Glu Glu 2525 2530 2535 Asp Ala Gln Arg Phe Arg Lys Gln Ala Glu Glu Ile Gly Glu Lys 2540 2545 2550 Leu His Arg Thr Glu Leu Ala Thr Gln Glu Lys Val Thr Leu Val 2555 2560 2565 Gln Thr Leu Glu Ile Gln Arg Gln Gln Ser Asp His Asp Ala Glu 2570 2575 2580 Arg Leu Arg Glu Ala Ile Ala Glu Leu Glu Arg Glu Lys Glu Lys 2585 ​​2590 2595 Leu Gln Gln Glu Ala Lys Leu Leu Gln Leu Lys Ser Glu Glu Met 2600 2605 2610 Gln Thr Val Gln Gln Glu Gln Leu Leu Gln Glu Thr Gln Ala Leu 2615 2620 2625 Gln Gln Ser Phe Leu Ser Glu Lys Asp Ser Leu Leu Gln Arg Glu 2630 2635 2640 Arg Phe Ile Glu Gln Glu Lys Ala Lys Leu Glu Gln Leu Phe Gln 2645 2650 2655 Asp Glu Val Ala Lys Ala Gln Gln Leu Arg Glu Glu Gln Gln Arg 2660 2665 2670 Gln Gln Gln Gln Met Glu Gln Glu Arg Gln Arg Leu Val Ala Ser 2675 2680 2685 Met Glu Glu Ala Arg Arg Arg Gln His Glu Ala Glu Glu Gly Val 2690 2695 2700 Arg Arg Lys Gln Glu Glu Leu Gln Gln Leu Glu Gln Gln Arg Arg 2705 2710 2715 Gln Gln Glu Glu Leu Leu Ala Glu Glu Asn Gln Arg Leu Arg Glu 2720 2725 2730 Gln Leu Gln Leu Leu Glu Glu Gln His Arg Ala Ala Leu Ala His 2735 2740 2745 Ser Glu Glu Val Thr Ala Ser Gln Val Ala Ala Thr Lys Thr Leu 2750 2755 2760 Pro Asn Gly Arg Asp Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu 2765 2770 2775 Pro Glu His Ser Phe Asp Gly Leu Arg Arg Lys Val Ser Ala Gln 2780 2785 2790 Arg Leu Gln Glu Ala Gly Ile Leu Ser Ala Glu Glu Leu Gln Arg 2795 2800 2805 Leu Ala Gln Gly His Thr Thr Val Asp Glu Leu Ala Arg Arg Glu 2810 2815 2820 Asp Val Arg His Tyr Leu Gln Gly Arg Ser Ser Ile Ala Gly Leu 2825 2830 2835 Leu Leu Lys Ala Thr Asn Glu Lys Leu Ser Val Tyr Ala Ala Leu 2840 2845 2850 Gln Arg Gln Leu Leu Ser Pro Gly Thr Ala Leu Ile Leu Leu Glu 2855 2860 2865 Ala Gln Ala Ala Ser Gly Phe Leu Leu Asp Pro Val Arg Asn Arg 2870 2875 2880 Arg Leu Thr Val Asn Glu Ala Val Lys Glu Gly Val Val Gly Pro 2885 2890 2895 Glu Leu His His Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly 2900 2905 2910 Tyr Lys Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala 2915 2920 2925 Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu 2930 2935 2940 Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser 2945 2950 2955 His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp 2960 2965 2970 Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys 2975 2980 2985 Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln 2990 2995 3000 Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Cys Leu 3005 3010 3015 Leu Pro Leu Thr Asp Lys Ala Ala Lys Gly Gly Glu Leu Val Tyr 3020 3025 3030 Thr Asp Ser Glu Ala Arg Asp Val Phe Glu Lys Ala Thr Val Ser 3035 3040 3045 Ala Pro Phe Gly Lys Phe Gln Gly Lys Thr Val Thr Ile Trp Glu 3050 3055 3060 Ile Ile Asn Ser Glu Tyr Phe Thr Ala Glu Gln Arg Arg Asp Leu 3065 3070 3075 Leu Arg Gln Phe Arg Thr Gly Arg Ile Thr Val Glu Lys Ile Ile 3080 3085 3090 Lys Ile Ile Ile Thr Val Val Glu Glu Gln Glu Gln Lys Gly Arg 3095 3100 3105 Leu Cys Phe Glu Gly Leu Arg Ser Leu Val Pro Ala Ala Glu Leu 3110 3115 3120 Leu Glu Ser Arg Val Ile Asp Arg Glu Leu Tyr Gln Gln Leu Gln 3125 3130 3135 Arg Gly Glu Arg Ser Val Arg Asp Val Ala Glu Val Asp Thr Val 3140 3145 3150 Arg Arg Ala Leu Arg Gly Ala Asn Val Ile Ala Gly Val Trp Leu 3155 3160 3165 Glu Glu Ala Gly Gln Lys Leu Ser Ile Tyr Asn Ala Leu Lys Lys 3170 3175 3180 Asp Leu Leu Pro Ser Asp Met Ala Val Ala Leu Leu Glu Ala Gln 3185 3190 3195 Ala Gly Thr Gly His Ile Ile Asp Pro Ala Thr Ser Ala Arg Leu 3200 3205 3210 Thr Val Asp Glu Ala Val Arg Ala Gly Leu Val Gly Pro Glu Phe 3215 3220 3225 His Glu Lys Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr Arg 3230 3235 3240 Asp Pro Tyr Thr Gly Gln Ser Val Ser Leu Phe Gln Ala Leu Lys 3245 3250 3255 Lys Gly Leu Ile Pro Arg Glu Gln Gly Leu Arg Leu Leu Asp Ala 3260 3265 3270 Gln Leu Ser Thr Gly Gly Ile Val Asp Pro Ser Lys Ser His Arg 3275 3280 3285 Val Pro Leu Asp Val Ala Cys Ala Arg Gly Cys Leu Asp Glu Glu 3290 3295 3300 Thr Ser Arg Ala Leu Ser Ala Pro Arg Ala Asp Ala Lys Ala Tyr 3305 3310 3315 Ser Asp Pro Ser Thr Gly Glu Pro Ala Thr Tyr Gly Glu Leu Gln 3320 3325 3330 Gln Arg Cys Arg Pro Asp Gln Leu Thr Gly Leu Ser Leu Leu Pro 3335 3340 3345 Leu Ser Glu Lys Ala Ala Arg Ala Arg Gln Glu Glu Leu Tyr Ser 3350 3355 3360 Glu Leu Gln Ala Arg Glu Thr Phe Glu Lys Thr Pro Val Glu Val 3365 3370 3375 Pro Val Gly Gly Phe Lys Gly Arg Thr Val Thr Val Trp Glu Leu 3380 3385 3390 Ile Ser Ser Glu Tyr Phe Thr Ala Glu Gln Arg Gln Glu Leu Leu 3395 3400 3405 Arg Gln Phe Arg Thr Gly Lys Val Thr Val Glu Lys Val Ile Lys 3410 3415 3420 Ile Leu Ile Thr Ile Val Glu Glu Val Glu Thr Leu Arg Gln Glu 3425 3430 3435 Arg Leu Ser Phe Ser Gly Leu Arg Ala Pro Val Pro Ala Ser Glu 3440 3445 3450 Leu Leu Ala Ser Gly Val Leu Ser Arg Ala Gln Phe Glu Gln Leu 3455 3460 3465 Lys Asp Gly Lys Thr Val Lys Asp Leu Ser Glu Leu Gly Ser 3470 3475 3480 Val Arg Thr Leu Leu Gln Gly Ser Gly Cys Leu Ala Gly Ile Tyr 3485 3490 3495 Leu Glu Asp Thr Lys Glu Lys Val Ser Ile Tyr Glu Ala Met Arg 3500 3505 3510 Arg Gly Leu Leu Arg Ala Thr Thr Ala Ala Leu Leu Leu Glu Ala 3515 3520 3525 Gln Ala Ala Thr Gly Phe Leu Val Asp Pro Val Arg Asn Gln Arg 3530 3535 3540 Leu Tyr Val His Glu Ala Val Lys Ala Gly Val Val Gly Pro Glu 3545 3550 3555 Leu His Glu Gln Leu Leu Ser Ala Glu Lys Ala Val Thr Gly Tyr 3560 3565 3570 Arg Asp Pro Tyr Ser Gly Ser Thr Ile Ser Leu Phe Gln Ala Met 3575 3580 3585 Gln Lys Gly Leu Val Leu Arg Gln His Gly Ile Arg Leu Leu Glu 3590 3595 3600 Ala Gln Ile Ala Thr Gly Gly Ile Ile Asp Pro Val His Ser His 3605 3610 3615 Arg Val Pro Val Asp Val Ala Tyr Gln Arg Gly Tyr Phe Ser Glu 3620 3625 3630 Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly 3635 3640 3645 Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Arg Gln Leu 3650 3655 3660 Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Arg Leu Leu 3665 3670 3675 Pro Leu Lys Gly Ala Glu Lys Ala Glu Val Val Glu Thr Thr Gln 3680 3685 3690 Val Tyr Thr Glu Glu Glu Thr Arg Arg Ala Phe Glu Glu Thr Gln 3695 3700 3705 Ile Asp Ile Pro Gly Gly Gly Ser His Gly Gly Ser Thr Met Ser 3710 3715 3720 Leu Trp Glu Val Met Gln Ser Asp Leu Ile Pro Glu Glu Gln Arg 3725 3730 3735 Ala Gln Leu Met Ala Asp Phe Gln Ala Gly Arg Val Thr Lys Glu 3740 3745 3750 Arg Met Ile Ile Ile Ile Ile Glu Ile Ile Glu Lys Thr Glu Ile 3755 3760 3765 Ile Arg Gln Gln Gly Leu Ala Ser Tyr Asp Tyr Val Arg Arg Arg 3770 3775 3780 Leu Thr Ala Glu Asp Leu Phe Glu Ala Arg Ile Ile Ser Leu Glu 3785 3790 3795 Thr Tyr Asn Leu Leu Arg Glu Gly Thr Arg Ser Leu Arg Glu Ala 3800 3805 3810 Leu Glu Ala Glu Ser Ala Trp Cys Tyr Leu Tyr Gly Thr Gly Ser 3815 3820 3825 Val Ala Gly Val Tyr Leu Pro Gly Ser Arg Gln Thr Leu Ser Ile 3830 3835 3840 Tyr Gln Ala Leu Lys Lys Gly Leu Leu Ser Ala Glu Val Ala Arg 3845 3850 3855 Leu Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu Leu Asp Pro 3860 3865 3870 Val Lys Gly Glu Arg Leu Thr Val Asp Glu Ala Val Arg Lys Gly 3875 3880 3885 Leu Val Gly Pro Glu Leu His Asp Arg Leu Leu Ser Ala Glu Arg 3890 3895 3900 Ala Val Thr Gly Tyr Arg Asp Pro Tyr Thr Glu Gln Thr Ile Ser 3905 3910 3915 Leu Phe Gln Ala Met Lys Lys Glu Leu Ile Pro Thr Glu Glu Ala 3920 3925 3930 Leu Arg Leu Leu Asp Ala Gln Leu Ala Thr Gly Gly Ile Val Asp 3935 3940 3945 Pro Arg Leu Gly Phe His Leu Pro Leu Glu Val Ala Tyr Gln Arg 3950 3955 3960 Gly Tyr Leu Asn Lys Asp Thr His Asp Gln Leu Ser Glu Pro Ser 3965 3970 3975 Glu Val Arg Ser Tyr Val Asp Pro Ser Thr Asp Glu Arg Leu Ser 3980 3985 3990 Tyr Thr Gln Leu Leu Arg Arg Cys Arg Arg Asp Asp Gly Thr Gly 3995 4000 4005 Gln Leu Leu Leu Pro Leu Ser Asp Ala Arg Lys Leu Thr Phe Arg 4010 4015 4020 Gly Leu Arg Lys Gln Ile Thr Met Glu Glu Leu Val Arg Ser Gln 4025 4030 4035 Val Met Asp Glu Ala Thr Ala Leu Gln Leu Arg Glu Gly Leu Thr 4040 4045 4050 Ser Ile Glu Glu Val Thr Lys Asn Leu Gln Lys Phe Leu Glu Gly 4055 4060 4065 Thr Ser Cys Ile Ala Gly Val Phe Val Asp Ala Thr Lys Glu Arg 4070 4075 4080 Leu Ser Val Tyr Gln Ala Met Lys Lys Gly Ile Ile Arg Pro Gly 4085 4090 4095 Thr Ala Phe Glu Leu Leu Glu Ala Gln Ala Ala Thr Gly Tyr Val 4100 4105 4110 Ile Asp Pro Ile Lys Gly Leu Lys Leu Thr Val Glu Glu Ala Val 4115 4120 4125 Arg Met Gly Ile Val Gly Pro Glu Phe Lys Asp Lys Leu Leu Ser 4130 4135 4140 Ala Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Ser Gly Lys 4145 4150 4155 Leu Ile Ser Leu Phe Gln Ala Met Lys Lys Gly Leu Ile Leu Lys 4160 4165 4170 Asp His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly 4175 4180 4185 Ile Ile Asp Pro Glu Glu Ser His Arg Leu Pro Val Glu Val Ala 4190 4195 4200 Tyr Lys Arg Gly Leu Phe Asp Glu Glu Met Asn Glu Ile Leu Thr 4205 4210 4215 Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr Glu 4220 4225 4230 Glu Asn Leu Thr Tyr Leu Gln Leu Met Glu Arg Cys Ile Thr Asp 4235 4240 4245 Pro Gln Thr Gly Leu Cys Leu Leu Pro Leu Lys Glu Lys Lys Arg 4250 4255 4260 Glu Arg Lys Thr Ser Ser Lys Ser Ser Val Arg Lys Arg Arg Val 4265 4270 4275 Val Ile Val Asp Pro Glu Thr Gly Lys Glu Met Ser Val Tyr Glu 4280 4285 4290 Ala Tyr Arg Lys Gly Leu Ile Asp His Gln Thr Tyr Leu Glu Leu 4295 4300 4305 Ser Glu Gln Glu Cys Glu Trp Glu Glu Ile Thr Ile Ser Ser Ser 4310 4315 4320 Asp Gly Val Val Lys Ser Met Ile Ile Asp Arg Arg Ser Gly Arg 4325 4330 4335 Gln Tyr Asp Ile Asp Asp Ala Ile Ala Lys Asn Leu Ile Asp Arg 4340 4345 4350 Ser Ala Leu Asp Gln Tyr Arg Ala Gly Thr Leu Ser Ile Thr Glu 4355 4360 4365 Phe Ala Asp Met Leu Ser Gly Asn Ala Gly Gly Phe Arg Ser Arg 4370 4375 4380 Ser Ser Ser Val Gly Ser Ser Ser Ser Tyr Pro Ile Ser Pro Ala 4385 4390 4395 Val Ser Arg Thr Gln Leu Ala Ser Trp Ser Asp Pro Thr Glu Glu 4400 4405 4410 Thr Gly Pro Val Ala Gly Ile Leu Asp Thr Glu Thr Leu Glu Lys 4415 4420 4425 Val Ser Ile Thr Glu Ala Met His Arg Asn Leu Val Asp Asn Ile 4430 4435 4440 Thr Gly Gln Arg Leu Leu Glu Ala Gln Ala Cys Thr Gly Gly Ile 4445 4450 4455 Ile Asp Pro Ser Thr Gly Glu Arg Phe Pro Val Thr Asp Ala Val 4460 4465 4470 Asn Lys Gly Leu Val Asp Lys Ile Met Val Asp Arg Ile Asn Leu 4475 4480 4485 Ala Gln Lys Ala Phe Cys Gly Phe Glu Asp Pro Arg Thr Lys Thr 4490 4495 4500 Lys Met Ser Ala Ala Gln Ala Leu Lys Lys Gly Trp Leu Tyr Tyr 4505 4510 4515 Glu Ala Gly Gln Arg Phe Leu Glu Val Gln Tyr Leu Thr Gly Gly 4520 4525 4530 Leu Ile Glu Pro Asp Thr Pro Gly Arg Val Pro Leu Asp Glu Ala 4535 4540 4545 Leu Gln Arg Gly Thr Val Asp Ala Arg Thr Ala Gln Lys Leu Arg 4550 4555 4560 Asp Val Gly Ala Tyr Ser Lys Tyr Leu Thr Cys Pro Lys Thr Lys 4565 4570 4575 Leu Lys Ile Ser Tyr Lys Asp Ala Leu Asp Arg Ser Met Val Glu 4580 4585 4590 Glu Gly Thr Gly Leu Arg Leu Leu Glu Ala Ala Ala Gln Ser Thr 4595 4600 4605 Lys Gly Tyr Tyr Ser Pro Tyr Ser Val Ser Gly Ser Gly Ser Thr 4610 4615 4620 Ala Gly Ser Arg Thr Gly Ser Arg Thr Gly Ser Arg Ala Gly Ser 4625 4630 4635 Arg Arg Gly Ser Phe Asp Ala Thr Gly Ser Gly Phe Ser Met Thr 4640 4645 4650 Phe Ser Ser Ser Ser Tyr Ser Ser Ser Gly Tyr Gly Arg Arg Tyr 4655 4660 4665 Ala Ser Gly Ser Ser Ala Ser Leu Gly Gly Pro Glu Ser Ala Val 4670 4675 4680 Ala <210> 6 <211> 654 <212> PRT <213> Homo sapiens <400> 6 Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 1 5 10 15 Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 20 25 30 Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 35 40 45 Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 50 55 60 Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 65 70 75 80 Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 85 90 95 Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 100 105 110 Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 115 120 125 Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 130 135 140 Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 145 150 155 160 Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 165 170 175 Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 180 185 190 Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 195 200 205 Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 210 215 220 Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 225 230 235 240 Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 245 250 255 Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 260 265 270 Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 275 280 285 Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 290 295 300 Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 305 310 315 320 Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 325 330 335 Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 340 345 350 Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 355 360 365 Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 370 375 380 Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 385 390 395 400 Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 405 410 415 Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 420 425 430 Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 435 440 445 Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 450 455 460 Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 465 470 475 480 Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 485 490 495 Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 500 505 510 Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 515 520 525 Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 530 535 540 Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 545 550 555 560 Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 565 570 575 Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 580 585 590 Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 595 600 605 Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 610 615 620 Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 625 630 635 640 Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 645 650 <210> 7 <211> 710 <212> PRT <213> Homo sapiens <400> 7 Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 1 5 10 15 Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 20 25 30 Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 35 40 45 Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 50 55 60 Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 65 70 75 80 Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 85 90 95 Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 100 105 110 Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 115 120 125 Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 130 135 140 Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 145 150 155 160 Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 165 170 175 Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 180 185 190 Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 195 200 205 Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 210 215 220 Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 225 230 235 240 Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 245 250 255 Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 260 265 270 Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 275 280 285 Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 290 295 300 Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 305 310 315 320 Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 325 330 335 Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 340 345 350 Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 355 360 365 Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 370 375 380 Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 385 390 395 400 Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 405 410 415 Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 420 425 430 Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 435 440 445 Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 450 455 460 Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 465 470 475 480 Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 485 490 495 Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 500 505 510 Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 515 520 525 Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 530 535 540 Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 545 550 555 560 Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 565 570 575 Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 580 585 590 Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 595 600 605 Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 610 615 620 Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val 625 630 635 640 Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg 645 650 655 Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly 660 665 670 Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly 675 680 685 Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly 690 695 700 Lys Lys Thr Lys Phe Glu 705 710 <210> 8 <211> 284 <212> PRT <213> Homo sapiens <400> 8 Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 1 5 10 15 Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 20 25 30 Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 35 40 45 Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 50 55 60 Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 65 70 75 80 Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 85 90 95 Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 100 105 110 Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 115 120 125 Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 130 135 140 Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 145 150 155 160 Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 165 170 175 Glu Arg Path Glu Glu Arg Path Glu Leu Ser Glu Gly Lys Cys Path Glu 180 185 190 Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 195 200 205 Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 210 215 220 Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 225 230 235 240 Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 245 250 255 Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 260 265 270 Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 275 280 <210> 9 <211> 2201 <212> PRT <213> Homo sapiens <400> 9 Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 1 5 10 15 Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 20 25 30 Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 35 40 45 Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 50 55 60 Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 65 70 75 80 Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 85 90 95 Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 100 105 110 Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 115 120 125 Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 130 135 140 Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 145 150 155 160 Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 165 170 175 Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 180 185 190 Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 195 200 205 Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 210 215 220 Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 225 230 235 240 Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 245 250 255 Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 260 265 270 Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 275 280 285 Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 290 295 300 Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 305 310 315 320 Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 325 330 335 Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 340 345 350 Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 355 360 365 Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 370 375 380 Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 385 390 395 400 Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 405 410 415 Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 420 425 430 Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 435 440 445 Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 450 455 460 Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 465 470 475 480 Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 485 490 495 Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 500 505 510 Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 515 520 525 Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 530 535 540 Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 545 550 555 560 Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 565 570 575 Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 580 585 590 Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 595 600 605 Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 610 615 620 Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 625 630 635 640 Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 645 650 655 Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 660 665 670 Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 675 680 685 Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 690 695 700 Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 705 710 715 720 Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 725 730 735 Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 740 745 750 Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 755 760 765 Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 770 775 780 Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 785 790 795 800 Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 805 810 815 Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 820 825 830 Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 835 840 845 Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 850 855 860 Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 865 870 875 880 Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 885 890 895 Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 900 905 910 Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 915 920 925 Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 930 935 940 Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 945 950 955 960 Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 965 970 975 Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 980 985 990 Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu Leu Trp Lys Thr Pro 995 1000 1005 Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr Ser Leu Pro Thr 1010 1015 1020 Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr Thr Ser Tyr 1025 1030 1035 Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val Leu Leu 1040 1045 1050 Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val Lys 1055 1060 1065 Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 1070 1075 1080 Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 1085 1090 1095 Gln Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys 1100 1105 1110 Val Glu Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala 1115 1120 1125 Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser 1130 1135 1140 Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala 1145 1150 1155 Glu Ala Ser Thr Gly Glu Thr Pro Asn Leu Gly Glu Val Val Val 1160 1165 1170 Ala Glu Val Gly Trp Asp Ala Leu Lys Leu Asn Trp Thr Ala Pro 1175 1180 1185 Glu Gly Ala Tyr Glu Tyr Phe Phe Ile Gln Val Gln Glu Ala Asp 1190 1195 1200 Thr Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Gly Leu Arg 1205 1210 1215 Ser Thr Asp Leu Pro Gly Leu Lys Ala Ala Thr His Tyr Thr Ile 1220 1225 1230 Thr Ile Arg Gly Val Thr Gln Asp Phe Ser Thr Thr Pro Leu Ser 1235 1240 1245 Val Glu Val Leu Thr Glu Glu Val Pro Asp Met Gly Asn Leu Thr 1250 1255 1260 Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn Trp Thr Thr 1265 1270 1275 Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln Glu Ala 1280 1285 1290 Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser Leu 1295 1300 1305 Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 1310 1315 1320 Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu 1325 1330 1335 Ala Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu 1340 1345 1350 Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr 1355 1360 1365 Ala Ala Asp Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu 1370 1375 1380 Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser 1385 1390 1395 Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr 1400 1405 1410 Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val 1415 1420 1425 Leu Ser Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn 1430 1435 1440 Leu Asn Val Ser Asp Ile Thr Pro Glu Ser Phe Asn Leu Ser Trp 1445 1450 1455 Met Ala Thr Asp Gly Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile 1460 1465 1470 Asp Ser Asn Arg Leu Leu Glu Thr Val Glu Tyr Asn Ile Ser Gly 1475 1480 1485 Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro Pro Ser Thr Asp 1490 1495 1500 Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile Arg Thr Lys 1505 1510 1515 Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu Leu Glu 1520 1525 1530 Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val Ser 1535 1540 1545 Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val 1550 1555 1560 Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser 1565 1570 1575 Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile 1580 1585 1590 Gly Tyr Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr 1595 1600 1605 Lys Pro Leu Arg Ala Glu Ile Val Thr Glu Ala Glu Pro Glu Val 1610 1615 1620 Asp Asn Leu Leu Val Ser Asp Ala Thr Pro Asp Gly Phe Arg Leu 1625 1630 1635 Ser Trp Thr Ala Asp Glu Gly Val Phe Asp Asn Phe Val Leu Lys 1640 1645 1650 Ile Arg Asp Thr Lys Lys Gln Ser Glu Pro Leu Glu Ile Thr Leu 1655 1660 1665 Leu Ala Pro Glu Arg Thr Arg Asp Ile Thr Gly Leu Arg Glu Ala 1670 1675 1680 Thr Glu Tyr Glu Ile Glu Leu Tyr Gly Ile Ser Lys Gly Arg Arg 1685 1690 1695 Ser Gln Thr Val Ser Ala Ile Ala Thr Thr Ala Met Gly Ser Pro 1700 1705 1710 Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val 1715 1720 1725 Ser Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr 1730 1735 1740 Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp 1745 1750 1755 Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val 1760 1765 1770 Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser 1775 1780 1785 Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser 1790 1795 1800 Gly Leu Val Thr Ala Asn Ile Thr Asp Ser Glu Ala Leu Ala Arg 1805 1810 1815 Trp Gln Pro Ala Ile Ala Thr Val Asp Ser Tyr Val Ile Ser Tyr 1820 1825 1830 Thr Gly Glu Lys Val Pro Glu Ile Thr Arg Thr Val Ser Gly Asn 1835 1840 1845 Thr Val Glu Tyr Ala Leu Thr Asp Leu Glu Pro Ala Thr Glu Tyr 1850 1855 1860 Thr Leu Arg Ile Phe Ala Glu Lys Gly Pro Gln Lys Ser Ser Thr 1865 1870 1875 Ile Thr Ala Lys Phe Thr Thr Asp Leu Asp Ser Pro Arg Asp Leu 1880 1885 1890 Thr Ala Thr Glu Val Gln Ser Glu Thr Ala Leu Leu Thr Trp Arg 1895 1900 1905 Pro Pro Arg Ala Ser Val Thr Gly Tyr Leu Leu Val Tyr Glu Ser 1910 1915 1920 Val Asp Gly Thr Val Lys Glu Val Ile Val Gly Pro Asp Thr Thr 1925 1930 1935 Ser Tyr Ser Leu Ala Asp Leu Ser Pro Ser Thr His Tyr Thr Ala 1940 1945 1950 Lys Ile Gln Ala Leu Asn Gly Pro Leu Arg Ser Asn Met Ile Gln 1955 1960 1965 Thr Ile Phe Thr Thr Ile Gly Leu Leu Tyr Pro Phe Pro Lys Asp 1970 1975 1980 Cys Ser Gln Ala Met Leu Asn Gly Asp Thr Thr Ser Gly Leu Tyr 1985 1990 1995 Thr Ile Tyr Leu Asn Gly Asp Lys Ala Glu Ala Leu Glu Val Phe 2000 2005 2010 Cys Asp Met Thr Ser Asp Gly Gly Gly Trp Ile Val Phe Leu Arg 2015 2020 2025 Arg Lys Asn Gly Arg Glu Asn Phe Tyr Gln Asn Trp Lys Ala Tyr 2030 2035 2040 Ala Ala Gly Phe Gly Asp Arg Arg Glu Glu Phe Trp Leu Gly Leu 2045 2050 2055 Asp Asn Leu Asn Lys Ile Thr Ala Gln Gly Gln Tyr Glu Leu Arg 2060 2065 2070 Val Asp Leu Arg Asp His Gly Glu Thr Ala Phe Ala Val Tyr Asp 2075 2080 2085 Lys Phe Ser Val Gly Asp Ala Lys Thr Arg Tyr Lys Leu Lys Val 2090 2095 2100 Glu Gly Tyr Ser Gly Thr Ala Gly Asp Ser Met Ala Tyr His Asn 2105 2110 2115 Gly Arg Ser Phe Ser Thr Phe Asp Lys Asp Thr Asp Ser Ala Ile 2120 2125 2130 Thr Asn Cys Ala Leu Ser Tyr Lys Gly Ala Phe Trp Tyr Arg Asn 2135 2140 2145 Cys His Arg Val Asn Leu Met Gly Arg Tyr Gly Asp Asn Asn His 2150 2155 2160 Ser Gln Gly Val Asn Trp Phe His Trp Lys Gly His Glu His Ser 2165 2170 2175 Ile Gln Phe Ala Glu Met Lys Leu Arg Pro Ser Asn Phe Arg Asn 2180 2185 2190 Leu Glu Gly Arg Arg Lys Arg Ala 2195 2200 <210> 10 <211> 291 <212> PRT <213> Homo sapiens <400> 10 Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 1 5 10 15 Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 20 25 30 Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 35 40 45 Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 50 55 60 Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 65 70 75 80 Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 85 90 95 Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 100 105 110 Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 115 120 125 Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 130 135 140 Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 145 150 155 160 Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 165 170 175 Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 180 185 190 Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 195 200 205 Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 210 215 220 Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 225 230 235 240 Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 245 250 255 Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 260 265 270 Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 275 280 285 Gln Ser Lys 290 <210> 11 <211> 1838 <212> PRT <213> Homo sapiens <400> 11 Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 1 5 10 15 Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 20 25 30 Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 35 40 45 His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 50 55 60 Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 65 70 75 80 Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 85 90 95 Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 100 105 110 Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 115 120 125 Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 130 135 140 Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 145 150 155 160 Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 165 170 175 Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 180 185 190 Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 195 200 205 Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 210 215 220 Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 225 230 235 240 Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 245 250 255 Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 260 265 270 Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 275 280 285 Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 290 295 300 Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 305 310 315 320 Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 325 330 335 Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 340 345 350 Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 355 360 365 Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 370 375 380 Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 385 390 395 400 Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 405 410 415 Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 420 425 430 Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 435 440 445 Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 450 455 460 Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 465 470 475 480 Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 485 490 495 Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 500 505 510 Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 515 520 525 Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 530 535 540 Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 545 550 555 560 Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 565 570 575 Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 580 585 590 Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 595 600 605 Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 610 615 620 Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 625 630 635 640 Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 645 650 655 Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 660 665 670 Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 675 680 685 Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 690 695 700 Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 705 710 715 720 Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 725 730 735 Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 740 745 750 Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 755 760 765 Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 770 775 780 Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 785 790 795 800 Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 805 810 815 Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 820 825 830 Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 835 840 845 Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 850 855 860 Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 865 870 875 880 Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 885 890 895 Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 900 905 910 Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 915 920 925 Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 930 935 940 Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 945 950 955 960 Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 965 970 975 His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 980 985 990 Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Thr Gly Glu Thr 995 1000 1005 Gly Pro Met Gly Glu Arg Gly His Pro Gly Pro Pro Gly Pro Pro 1010 1015 1020 Gly Glu Gln Gly Leu Pro Gly Leu Ala Gly Lys Glu Gly Thr Lys 1025 1030 1035 Gly Asp Pro Gly Pro Ala Gly Leu Pro Gly Lys Asp Gly Pro Pro 1040 1045 1050 Gly Leu Arg Gly Phe Pro Gly Asp Arg Gly Leu Pro Gly Pro Val 1055 1060 1065 Gly Ala Leu Gly Leu Lys Gly Asn Glu Gly Pro Pro Gly Pro Pro 1070 1075 1080 Gly Pro Ala Gly Ser Pro Gly Glu Arg Gly Pro Ala Gly Ala Ala 1085 1090 1095 Gly Pro Ile Gly Ile Pro Gly Arg Pro Gly Pro Gln Gly Pro Pro 1100 1105 1110 Gly Pro Ala Gly Glu Lys Gly Ala Pro Gly Glu Lys Gly Pro Gln 1115 1120 1125 Gly Pro Ala Gly Arg Asp Gly Leu Gln Gly Pro Val Gly Leu Pro 1130 1135 1140 Gly Pro Ala Gly Pro Val Gly Pro Pro Gly Glu Asp Gly Asp Lys 1145 1150 1155 Gly Glu Ile Gly Glu Pro Gly Gln Lys Gly Ser Lys Gly Asp Lys 1160 1165 1170 Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly Pro Gln Gly Pro Ile 1175 1180 1185 Gly Gln Pro Gly Pro Ser Gly Ala Asp Gly Glu Pro Gly Pro Arg 1190 1195 1200 Gly Gln Gln Gly Leu Phe Gly Gln Lys Gly Asp Glu Gly Pro Arg 1205 1210 1215 Gly Phe Pro Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Pro 1220 1225 1230 Gly Pro Pro Gly Glu Lys Gly Glu Thr Gly Asp Val Gly Gln Met 1235 1240 1245 Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Ser Gly Ala Pro 1250 1255 1260 Gly Ala Asp Gly Pro Gln Gly Pro Pro Gly Gly Ile Gly Asn Pro 1265 1270 1275 Gly Ala Val Gly Glu Lys Gly Glu Pro Gly Glu Ala Gly Glu Pro 1280 1285 1290 Gly Leu Pro Gly Glu Gly Gly Pro Pro Gly Pro Lys Gly Glu Arg 1295 1300 1305 Gly Glu Lys Gly Glu Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro 1310 1315 1320 Gly Pro Lys Gly Pro Pro Gly Asp Asp Gly Pro Lys Gly Ser Pro 1325 1330 1335 Gly Pro Val Gly Phe Pro Gly Asp Pro Gly Pro Pro Gly Glu Pro 1340 1345 1350 Gly Pro Ala Gly Gln Asp Gly Pro Pro Gly Asp Lys Gly Asp Asp 1355 1360 1365 Gly Glu Pro Gly Gln Thr Gly Ser Pro Gly Pro Thr Gly Glu Pro 1370 1375 1380 Gly Pro Ser Gly Pro Pro Gly Lys Arg Gly Pro Pro Gly Pro Ala 1385 1390 1395 Gly Pro Glu Gly Arg Gln Gly Glu Lys Gly Ala Lys Gly Glu Ala 1400 1405 1410 Gly Leu Glu Gly Pro Pro Gly Lys Thr Gly Pro Ile Gly Pro Gln 1415 1420 1425 Gly Ala Pro Gly Lys Pro Gly Pro Asp Gly Leu Arg Gly Ile Pro 1430 1435 1440 Gly Pro Val Gly Glu Gln Gly Leu Pro Gly Ser Pro Gly Pro Asp 1445 1450 1455 Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Pro Gly Leu Lys 1460 1465 1470 Gly Asp Ser Gly Pro Lys Gly Glu Lys Gly His Pro Gly Leu Ile 1475 1480 1485 Gly Leu Ile Gly Pro Pro Gly Glu Gln Gly Glu Lys Gly Asp Arg 1490 1495 1500 Gly Leu Pro Gly Pro Gln Gly Ser Ser Gly Pro Lys Gly Glu Gln 1505 1510 1515 Gly Ile Thr Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Pro Pro 1520 1525 1530 Gly Leu Pro Gly Pro Pro Gly Pro Lys Gly Ala Lys Gly Ser Ser 1535 1540 1545 Gly Pro Thr Gly Pro Lys Gly Glu Ala Gly His Pro Gly Pro Pro 1550 1555 1560 Gly Pro Pro Gly Pro Pro Gly Glu Val Ile Gln Pro Leu Pro Ile 1565 1570 1575 Gln Ala Ser Arg Thr Arg Arg Asn Ile Asp Ala Ser Gln Leu Leu 1580 1585 1590 Asp Asp Gly Asn Gly Glu Asn Tyr Val Asp Tyr Ala Asp Gly Met 1595 1600 1605 Glu Glu Ile Phe Gly Ser Leu Asn Ser Leu Lys Leu Glu Ile Glu 1610 1615 1620 Gln Met Lys Arg Pro Leu Gly Thr Gln Gln Asn Pro Ala Arg Thr 1625 1630 1635 Cys Lys Asp Leu Gln Leu Cys His Pro Asp Phe Pro Asp Gly Glu 1640 1645 1650 Tyr Trp Val Asp Pro Asn Gln Gly Cys Ser Arg Asp Ser Phe Lys 1655 1660 1665 Val Tyr Cys Asn Phe Thr Ala Gly Gly Ser Thr Cys Val Phe Pro 1670 1675 1680 Asp Lys Lys Ser Glu Gly Ala Arg Ile Thr Ser Trp Pro Lys Glu 1685 1690 1695 Asn Pro Gly Ser Trp Phe Ser Glu Phe Lys Arg Gly Lys Leu Leu 1700 1705 1710 Ser Tyr Val Asp Ala Glu Gly Asn Pro Val Gly Val Val Gln Met 1715 1720 1725 Thr Phe Leu Arg Leu Leu Ser Ala Ser Ala His Gln Asn Val Thr 1730 1735 1740 Tyr His Cys Tyr Gln Ser Val Ala Trp Gln Asp Ala Ala Thr Gly 1745 1750 1755 Ser Tyr Asp Lys Ala Leu Arg Phe Leu Gly Ser Asn Asp Glu Glu 1760 1765 1770 Met Ser Tyr Asp Asn Asn Pro Tyr Ile Arg Ala Leu Val Asp Gly 1775 1780 1785 Cys Ala Thr Lys Lys Gly Tyr Gln Lys Thr Val Leu Glu Ile Asp 1790 1795 1800 Thr Pro Lys Val Glu Gln Val Pro Ile Val Asp Ile Met Phe Asn 1805 1810 1815 Asp Phe Gly Glu Ala Ser Gln Lys Phe Gly Phe Glu Val Gly Pro 1820 1825 1830 Ala Cys Phe Met Gly 1835 <210> 12 <211> 323 <212> PRT <213> Homo sapiens <400> 12 Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 1 5 10 15 Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 20 25 30 Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 35 40 45 Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 50 55 60 Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 65 70 75 80 Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 85 90 95 Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 100 105 110 Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 115 120 125 Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 130 135 140 Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 145 150 155 160 Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 165 170 175 Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 180 185 190 Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly 195 200 205 Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr 210 215 220 Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu 225 230 235 240 Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly 245 250 255 Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu 260 265 270 Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro 275 280 285 Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly 290 295 300 Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu 305 310 315 320 Phe Pro Phe <210> 13 <211> 2468 <212> PRT <213> Homo sapiens <400> 13 Met Ala Thr Val Val Val Glu Ala Thr Glu Pro Glu Pro Ser Gly Ser 1 5 10 15 Ile Ala Asn Pro Ala Ala Ser Thr Ser Pro Ser Leu Ser His Arg Phe 20 25 30 Leu Asp Ser Lys Phe Tyr Leu Leu Val Val Val Gly Glu Ile Val Thr 35 40 45 Glu Glu His Leu Arg Arg Ala Ile Gly Asn Ile Glu Leu Gly Ile Arg 50 55 60 Ser Trp Asp Thr Asn Leu Ile Glu Cys Asn Leu Asp Gln Glu Leu Lys 65 70 75 80 Leu Phe Val Ser Arg His Ser Ala Arg Phe Ser Pro Glu Val Pro Gly 85 90 95 Gln Lys Ile Leu His His Arg Ser Asp Val Leu Glu Thr Val Val Leu 100 105 110 Ile Asn Pro Ser Asp Glu Ala Val Ser Thr Glu Val Arg Leu Met Ile 115 120 125 Thr Asp Ala Ala Arg His Lys Leu Leu Val Leu Thr Gly Gln Cys Phe 130 135 140 Glu Asn Thr Gly Glu Leu Ile Leu Gln Ser Gly Ser Phe Ser Phe Gln 145 150 155 160 Asn Phe Ile Glu Ile Phe Thr Asp Gln Glu Ile Gly Glu Leu Leu Ser 165 170 175 Thr Thr His Pro Ala Asn Lys Ala Ser Leu Thr Leu Phe Cys Pro Glu 180 185 190 Glu Gly Asp Trp Lys Asn Ser Asn Leu Asp Arg His Asn Leu Gln Asp 195 200 205 Phe Ile Asn Ile Lys Leu Asn Ser Ala Ser Ile Leu Pro Glu Met Glu 210 215 220 Gly Leu Ser Glu Phe Thr Glu Tyr Leu Ser Glu Ser Val Glu Val Pro 225 230 235 240 Ser Pro Phe Asp Ile Leu Glu Pro Pro Thr Ser Gly Gly Phe Leu Lys 245 250 255 Leu Ser Lys Pro Cys Cys Tyr Ile Phe Pro Gly Gly Arg Gly Asp Ser 260 265 270 Ala Leu Phe Ala Val Asn Gly Phe Asn Met Leu Ile Asn Gly Gly Ser 275 280 285 Glu Arg Lys Ser Cys Phe Trp Lys Leu Ile Arg His Leu Asp Arg Val 290 295 300 Asp Ser Ile Leu Leu Thr His Ile Gly Asp Asp Asn Leu Pro Gly Ile 305 310 315 320 Asn Ser Met Leu Gln Arg Lys Ile Ala Glu Leu Glu Glu Glu Gln Ser 325 330 335 Gln Gly Ser Thr Thr Asn Ser Asp Trp Met Lys Asn Leu Ile Ser Pro 340 345 350 Asp Leu Gly Val Val Phe Leu Asn Val Pro Glu Asn Leu Lys Asn Pro 355 360 365 Glu Pro Asn Ile Lys Met Lys Arg Ser Ile Glu Glu Ala Cys Phe Thr 370 375 380 Leu Gln Tyr Leu Asn Lys Leu Ser Met Lys Pro Glu Pro Leu Phe Arg 385 390 395 400 Ser Val Gly Asn Thr Ile Asp Pro Val Ile Leu Phe Gln Lys Met Gly 405 410 415 Val Gly Lys Leu Glu Met Tyr Val Leu Asn Pro Val Lys Ser Ser Lys 420 425 430 Glu Met Gln Tyr Phe Met Gln Gln Trp Thr Gly Thr Asn Lys Asp Lys 435 440 445 Ala Glu Phe Ile Leu Pro Asn Gly Gln Glu Val Asp Leu Pro Ile Ser 450 455 460 Tyr Leu Thr Ser Val Ser Ser Leu Ile Val Trp His Pro Ala Asn Pro 465 470 475 480 Ala Glu Lys Ile Ile Arg Val Leu Phe Pro Gly Asn Ser Thr Gln Tyr 485 490 495 Asn Ile Leu Glu Gly Leu Glu Lys Leu Lys His Leu Asp Phe Leu Lys 500 505 510 Gln Pro Leu Ala Thr Gln Lys Asp Leu Thr Gly Gln Val Pro Thr Pro 515 520 525 Val Val Lys Gln Thr Lys Leu Lys Gln Arg Ala Asp Ser Arg Glu Ser 530 535 540 Leu Lys Pro Ala Ala Lys Pro Leu Pro Ser Lys Ser Val Arg Lys Glu 545 550 555 560 Ser Lys Glu Glu Thr Pro Glu Val Thr Lys Val Asn His Val Glu Lys 565 570 575 Pro Pro Lys Val Glu Ser Lys Glu Lys Val Met Val Lys Lys Asp Lys 580 585 590 Pro Ile Lys Thr Glu Thr Lys Pro Ser Val Thr Glu Lys Glu Val Pro 595 600 605 Ser Lys Glu Glu Pro Ser Pro Val Lys Ala Glu Val Ala Glu Lys Gln 610 615 620 Ala Thr Asp Val Lys Pro Lys Ala Ala Lys Glu Lys Thr Val Lys Lys 625 630 635 640 Glu Thr Lys Val Lys Pro Glu Asp Lys Lys Glu Glu Lys Glu Lys Pro 645 650 655 Lys Lys Glu Val Ala Lys Lys Glu Asp Lys Thr Pro Ile Lys Lys Glu 660 665 670 Glu Lys Pro Lys Lys Glu Glu Val Lys Lys Glu Val Lys Lys Glu Ile 675 680 685 Light Light Glu Glu Light Light Glu Pro Light Light Glu Val Light Light Glu Thr 690 695 700 Pro Pro Light Glu Val Light Light Glu Val Light Light Glu Glu Light Light Glu 705 710 715 720 Val Lys Lys Glu Glu Lys Glu Pro Lys Lys Glu Ile Lys Lys Leu Pro 725 730 735 Lys Asp Ala Lys Lys Ser Ser Thr Pro Leu Ser Glu Ala Lys Lys Pro 740 745 750 Ala Ala Leu Lys Pro Lys Val Pro Lys Lys Glu Glu Ser Val Lys Lys 755 760 765 Asp Ser Val Ala Ala Gly Lys Pro Lys Glu Lys Gly Lys Ile Lys Val 770 775 780 Ile Lys Lys Glu Gly Lys Ala Ala Glu Ala Val Ala Ala Ala Val Gly 785 790 795 800 Thr Gly Ala Thr Thr Ala Ala Val Met Ala Ala Ala Gly Ile Ala Ala 805 810 815 Ile Gly Pro Ala Lys Glu Leu Glu Ala Glu Arg Ser Leu Met Ser Ser 820 825 830 Pro Glu Asp Leu Thr Lys Asp Phe Glu Glu Leu Lys Ala Glu Glu Val 835 840 845 Asp Val Thr Lys Asp Ile Lys Pro Gln Leu Glu Leu Ile Glu Asp Glu 850 855 860 Glu Lys Leu Lys Glu Thr Glu Pro Val Glu Ala Tyr Val Ile Gln Lys 865 870 875 880 Glu Arg Glu Val Thr Lys Gly Pro Ala Glu Ser Pro Asp Glu Gly Ile 885 890 895 Thr Thr Thr Glu Gly Glu Gly Glu Cys Glu Gln Thr Pro Glu Glu Leu 900 905 910 Glu Pro Val Glu Lys Gln Gly Val Asp Asp Ile Glu Lys Phe Glu Asp 915 920 925 Glu Gly Ala Gly Phe Glu Glu Ser Ser Glu Thr Gly Asp Tyr Glu Glu 930 935 940 Lys Ala Glu Thr Glu Glu Ala Glu Glu Pro Glu Glu Asp Gly Glu Glu 945 950 955 960 His Val Cys Val Ser Ala Ser Lys His Ser Pro Thr Glu Asp Glu Glu 965 970 975 Ser Ala Lys Ala Glu Ala Asp Ala Tyr Ile Arg Glu Lys Arg Glu Ser 980 985 990 Val Ala Ser Gly Asp Asp Arg Ala Glu Glu Asp Met Asp Glu Ala Ile 995 1000 1005 Glu Lys Gly Glu Ala Glu Gln Ser Glu Glu Glu Ala Asp Glu Glu 1010 1015 1020 Asp Lys Ala Glu Asp Ala Arg Glu Glu Glu Tyr Glu Pro Glu Lys 1025 1030 1035 Met Glu Ala Glu Asp Tyr Val Met Ala Val Val Asp Lys Ala Ala 1040 1045 1050 Glu Ala Gly Gly Ala Glu Glu Gln Tyr Gly Phe Leu Thr Thr Pro 1055 1060 1065 Thr Lys Gln Leu Gly Ala Gln Ser Pro Gly Arg Glu Pro Ala Ser 1070 1075 1080 Ser Ile His Asp Glu Thr Leu Pro Gly Gly Ser Glu Ser Glu Ala 1085 1090 1095 Thr Ala Ser Asp Glu Glu Asn Arg Glu Asp Gln Pro Glu Glu Phe 1100 1105 1110 Thr Ala Thr Ser Gly Tyr Thr Gln Ser Thr Ile Glu Ile Ser Ser 1115 1120 1125 Glu Pro Thr Pro Met Asp Glu Met Ser Thr Pro Arg Asp Val Met 1130 1135 1140 Ser Asp Glu Thr Asn Asn Glu Glu Thr Glu Ser Pro Ser Gln Glu 1145 1150 1155 Phe Val Asn Ile Thr Lys Tyr Glu Ser Ser Leu Tyr Ser Gln Glu 1160 1165 1170 Tyr Ser Lys Pro Ala Asp Val Thr Pro Leu Asn Gly Phe Ser Glu 1175 1180 1185 Gly Ser Lys Thr Asp Ala Thr Asp Gly Lys Asp Tyr Asn Ala Ser 1190 1195 1200 Ala Ser Thr Ile Ser Pro Pro Ser Ser Met Glu Glu Asp Lys Phe 1205 1210 1215 Ser Arg Ser Ala Leu Arg Asp Ala Tyr Cys Ser Glu Val Lys Ala 1220 1225 1230 Ser Thr Thr Leu Asp Ile Lys Asp Ser Ile Ser Ala Val Ser Ser 1235 1240 1245 Glu Lys Val Ser Pro Ser Lys Ser Pro Ser Leu Ser Pro Ser Pro 1250 1255 1260 Pro Ser Pro Leu Glu Lys Thr Pro Leu Gly Glu Arg Ser Val Asn 1265 1270 1275 Phe Ser Leu Thr Pro Asn Glu Ile Lys Val Ser Ala Glu Ala Glu 1280 1285 1290 Val Ala Pro Val Ser Pro Glu Val Thr Gln Glu Val Val Glu Glu 1295 1300 1305 His Cys Ala Ser Pro Glu Asp Lys Thr Leu Glu Val Val Ser Pro 1310 1315 1320 Ser Gln Ser Val Thr Gly Ser Ala Gly His Thr Pro Tyr Tyr Gln 1325 1330 1335 Ser Pro Thr Asp Glu Lys Ser Ser His Leu Pro Thr Glu Val Ile 1340 1345 1350 Glu Lys Pro Pro Ala Val Pro Val Ser Phe Glu Phe Ser Asp Ala 1355 1360 1365 Lys Asp Glu Asn Glu Arg Ala Ser Val Ser Pro Met Asp Glu Pro 1370 1375 1380 Val Pro Asp Ser Glu Ser Pro Ile Glu Lys Val Leu Ser Pro Leu 1385 1390 1395 Arg Ser Pro Pro Leu Ile Gly Ser Glu Ser Ala Tyr Glu Ser Phe 1400 1405 1410 Leu Ser Ala Asp Asp Lys Ala Ser Gly Arg Gly Ala Glu Ser Pro 1415 1420 1425 Phe Glu Glu Lys Ser Gly Lys Gln Gly Ser Pro Asp Gln Val Ser 1430 1435 1440 Pro Val Ser Glu Met Thr Ser Thr Ser Leu Tyr Gln Asp Lys Gln 1445 1450 1455 Glu Gly Lys Ser Thr Asp Phe Ala Pro Ile Lys Glu Asp Phe Gly 1460 1465 1470 Gln Glu Lys Lys Thr Asp Asp Val Glu Ala Met Ser Ser Gln Pro 1475 1480 1485 Ala Leu Ala Leu Asp Glu Arg Lys Leu Gly Asp Val Ser Pro Thr 1490 1495 1500 Gln Ile Asp Val Ser Gln Phe Gly Ser Phe Lys Glu Asp Thr Lys 1505 1510 1515 Met Ser Ile Ser Glu Gly Thr Val Ser Asp Lys Ser Ala Thr Pro 1520 1525 1530 Val Asp Glu Gly Val Ala Glu Asp Thr Tyr Ser His Met Glu Gly 1535 1540 1545 Val Ala Ser Val Ser Thr Ala Ser Val Ala Thr Ser Ser Phe Pro 1550 1555 1560 Glu Pro Thr Thr Asp Asp Val Ser Pro Ser Leu His Ala Glu Val 1565 1570 1575 Gly Ser Pro His Ser Thr Glu Val Asp Asp Ser Leu Ser Val Ser 1580 1585 1590 Val Val Gln Thr Pro Thr Thr Phe Gln Glu Thr Glu Met Ser Pro 1595 1600 1605 Ser Lys Glu Glu Cys Pro Arg Pro Met Ser Ile Ser Pro Pro Asp 1610 1615 1620 Phe Ser Pro Lys Thr Ala Lys Ser Arg Thr Pro Val Gln Asp His 1625 1630 1635 Arg Ser Glu Gln Ser Ser Met Ser Ile Glu Phe Gly Gln Glu Ser 1640 1645 1650 Pro Glu Gln Ser Leu Ala Met Asp Phe Ser Arg Gln Ser Pro Asp 1655 1660 1665 His Pro Thr Val Gly Ala Gly Val Leu His Ile Thr Glu Asn Gly 1670 1675 1680 Pro Thr Glu Val Asp Tyr Ser Pro Ser Asp Met Gln Asp Ser Ser 1685 1690 1695 Leu Ser His Lys Ile Pro Pro Met Glu Glu Pro Ser Tyr Thr Gln 1700 1705 1710 Asp Asn Asp Leu Ser Glu Leu Ile Ser Val Ser Gln Val Glu Ala 1715 1720 1725 Ser Pro Ser Thr Ser Ser Ala His Thr Pro Ser Gln Ile Ala Ser 1730 1735 1740 Pro Leu Gln Glu Asp Thr Leu Ser Asp Val Ala Pro Pro Arg Asp 1745 1750 1755 Met Ser Leu Tyr Ala Ser Leu Thr Ser Glu Lys Val Gln Ser Leu 1760 1765 1770 Glu Gly Glu Lys Leu Ser Pro Lys Ser Asp Ile Ser Pro Leu Thr 1775 1780 1785 Pro Arg Glu Ser Ser Pro Leu Tyr Ser Pro Thr Phe Ser Asp Ser 1790 1795 1800 Thr Ser Ala Val Lys Glu Lys Thr Ala Thr Cys His Ser Ser Ser 1805 1810 1815 Ser Pro Pro Ile Asp Ala Ala Ser Ala Glu Pro Tyr Gly Phe Arg 1820 1825 1830 Ala Ser Val Leu Phe Asp Thr Met Gln His His Leu Ala Leu Asn 1835 1840 1845 Arg Asp Leu Ser Thr Pro Gly Leu Glu Lys Asp Ser Gly Gly Lys 1850 1855 1860 Thr Pro Gly Asp Phe Ser Tyr Ala Tyr Gln Lys Pro Glu Glu Thr 1865 1870 1875 Thr Arg Ser Pro Asp Glu Glu Asp Tyr Asp Tyr Glu Ser Tyr Glu 1880 1885 1890 Lys Thr Thr Arg Thr Ser Asp Val Gly Gly Tyr Tyr Tyr Glu Lys 1895 1900 1905 Ile Glu Arg Thr Thr Lys Ser Pro Ser Asp Ser Gly Tyr Ser Tyr 1910 1915 1920 Glu Thr Ile Gly Lys Thr Thr Lys Thr Pro Glu Asp Gly Asp Tyr 1925 1930 1935 Ser Tyr Glu Ile Ile Glu Lys Thr Thr Arg Thr Pro Glu Glu Gly 1940 1945 1950 Gly Tyr Ser Tyr Asp Ile Ser Glu Lys Thr Thr Ser Pro Pro Glu 1955 1960 1965 Val Ser Gly Tyr Ser Tyr Glu Lys Thr Glu Arg Ser Arg Arg Leu 1970 1975 1980 Leu Asp Asp Ile Ser Asn Gly Tyr Asp Asp Ser Glu Asp Gly Gly 1985 1990 1995 His Thr Leu Gly Asp Pro Ser Tyr Ser Tyr Glu Thr Thr Glu Lys 2000 2005 2010 Ile Thr Ser Phe Pro Glu Ser Glu Gly Tyr Ser Tyr Glu Thr Ser 2015 2020 2025 Thr Lys Thr Thr Arg Thr Pro Asp Thr Ser Thr Tyr Cys Tyr Glu 2030 2035 2040 Thr Ala Glu Lys Ile Thr Arg Thr Pro Gln Ala Ser Thr Tyr Ser 2045 2050 2055 Tyr Glu Thr Ser Asp Leu Cys Tyr Thr Ala Glu Lys Lys Ser Pro 2060 2065 2070 Ser Glu Ala Arg Gln Asp Val Asp Leu Cys Leu Val Ser Ser Cys 2075 2080 2085 Glu Tyr Lys His Pro Lys Thr Glu Leu Ser Pro Ser Phe Ile Asn 2090 2095 2100 Pro Asn Pro Leu Glu Trp Phe Ala Ser Glu Glu Pro Thr Glu Glu 2105 2110 2115 Ser Glu Lys Pro Leu Thr Gln Ser Gly Gly Ala Pro Pro Pro Pro 2120 2125 2130 Gly Gly Lys Gln Gln Gly Arg Gln Cys Asp Glu Thr Pro Pro Thr 2135 2140 2145 Ser Val Ser Glu Ser Ala Pro Ser Gln Thr Asp Ser Asp Val Pro 2150 2155 2160 Pro Glu Thr Glu Glu Cys Pro Ser Ile Thr Ala Asp Ala Asn Ile 2165 2170 2175 Asp Ser Glu Asp Glu Ser Glu Thr Ile Pro Thr Asp Lys Thr Val 2180 2185 2190 Thr Tyr Lys His Met Asp Pro Pro Pro Ala Pro Val Gln Asp Arg 2195 2200 2205 Ser Pro Ser Pro Arg His Pro Asp Val Ser Met Val Asp Pro Glu 2210 2215 2220 Ala Leu Ala Ile Glu Gln Asn Leu Gly Lys Ala Leu Lys Lys Asp 2225 2230 2235 Leu Lys Glu Lys Thr Lys Thr Lys Lys Pro Gly Thr Lys Thr Lys 2240 2245 2250 Ser Ser Ser Pro Val Lys Lys Ser Asp Gly Lys Ser Lys Pro Leu 2255 2260 2265 Ala Ala Ser Pro Lys Pro Ala Gly Leu Lys Glu Ser Ser Asp Lys 2270 2275 2280 Val Ser Arg Val Ala Ser Pro Lys Lys Lys Glu Ser Val Glu Lys 2285 2290 2295 Ala Ala Lys Pro Thr Thr Thr Pro Glu Val Lys Ala Ala Arg Gly 2300 2305 2310 Glu Glu Lys Asp Lys Glu Thr Lys Asn Ala Ala Asn Ala Ser Ala 2315 2320 2325 Ser Lys Ser Ala Lys Thr Ala Thr Ala Gly Pro Gly Thr Thr Lys 2330 2335 2340 Thr Thr Lys Ser Ser Ala Val Pro Pro Gly Leu Pro Val Tyr Leu 2345 2350 2355 Asp Leu Cys Tyr Ile Pro Asn His Ser Asn Ser Lys Asn Val Asp 2360 2365 2370 Val Glu Phe Phe Lys Arg Val Arg Ser Ser Tyr Tyr Val Val Ser 2375 2380 2385 Gly Asn Asp Pro Ala Ala Glu Glu Pro Ser Arg Ala Val Leu Asp 2390 2395 2400 Ala Leu Leu Glu Gly Lys Ala Gln Trp Gly Ser Asn Met Gln Val 2405 2410 2415 Thr Leu Ile Pro Thr His Asp Ser Glu Val Met Arg Glu Trp Tyr 2420 2425 2430 Gln Glu Thr His Glu Lys Gln Gln Asp Leu Asn Ile Met Val Leu 2435 2440 2445 Ala Ser Ser Ser Thr Val Val Met Gln Asp Glu Ser Phe Pro Ala 2450 2455 2460 Cys Lys Ile Glu Leu 2465 <210> 14 <211> 215 <212> PRT <213> Homo sapiens <400> 14 Met Pro Gly Glu Ala Thr Glu Thr Val Pro Ala Thr Glu Gln Glu Leu 1 5 10 15 Pro Gln Pro Gln Ala Glu Thr Gly Ser Gly Thr Glu Ser Asp Ser Asp 20 25 30 Glu Ser Val Pro Glu Leu Glu Glu Gln Asp Ser Thr Gln Ala Thr Thr 35 40 45 Gln Gln Ala Gln Leu Ala Ala Ala Ala Glu Ile Asp Glu Glu Pro Val 50 55 60 Ser Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 65 70 75 80 Ser Lys Leu Gly Leu Arg Gln Val Thr Gly Val Thr Arg Val Thr Ile 85 90 95 Arg Lys Ser Lys Asn Ile Leu Phe Val Ile Thr Lys Pro Asp Val Tyr 100 105 110 Lys Ser Pro Ala Ser Asp Thr Tyr Ile Val Phe Gly Glu Ala Lys Ile 115 120 125 Glu Asp Leu Ser Gln Gln Ala Gln Leu Ala Ala Ala Glu Lys Phe Lys 130 135 140 Val Gln Gly Glu Ala Val Ser Asn Ile Gln Glu Asn Thr Gln Thr Pro 145 150 155 160 Thr Val Gln Glu Glu Ser Glu Glu Glu Glu Val Asp Glu Thr Gly Val 165 170 175 Glu Val Lys Asp Ile Glu Leu Val Met Ser Gln Ala Asn Val Ser Arg 180 185 190 Ala Lys Ala Val Arg Ala Leu Lys Asn Asn Ser Asn Asp Ile Val Asn 195 200 205 Ala Ile Met Glu Leu Thr Met 210 215 <210> 15 <211> 234 <212> PRT <213> Homo sapiens <400> 15 Met Ala Glu Arg Gly Tyr Ser Phe Ser Leu Thr Thr Phe Ser Pro Ser 1 5 10 15 Gly Lys Leu Val Gln Ile Glu Tyr Ala Leu Ala Ala Val Ala Gly Gly 20 25 30 Ala Pro Ser Val Gly Ile Lys Ala Ala Asn Gly Val Val Leu Ala Thr 35 40 45 Glu Lys Lys Gln Lys Ser Ile Leu Tyr Asp Glu Arg Ser Val His Lys 50 55 60 Val Glu Pro Ile Thr Lys His Ile Gly Leu Val Tyr Ser Gly Met Gly 65 70 75 80 Pro Asp Tyr Arg Val Leu Val His Arg Ala Arg Lys Leu Ala Gln Gln 85 90 95 Tyr Tyr Leu Val Tyr Gln Glu Pro Ile Pro Thr Ala Gln Leu Val Gln 100 105 110 Arg Val Ala Ser Val Met Gln Glu Tyr Thr Gln Ser Gly Gly Val Arg 115 120 125 Pro Phe Gly Val Ser Leu Leu Ile Cys Gly Trp Asn Glu Gly Arg Pro 130 135 140 Tyr Leu Phe Gln Ser Asp Pro Ser Gly Ala Tyr Phe Ala Trp Lys Ala 145 150 155 160 Thr Ala Met Gly Lys Asn Tyr Val Asn Gly Lys Thr Phe Leu Glu Lys 165 170 175 Arg Tyr Asn Glu Asp Leu Glu Leu Glu Asp Ala Ile His Thr Ala Ile 180 185 190 Leu Thr Leu Lys Glu Ser Phe Glu Gly Gln Met Thr Glu Asp Asn Ile 195 200 205 Glu Val Gly Ile Cys Asn Glu Ala Gly Phe Arg Arg Leu Thr Pro Thr 210 215 220 Glu Val Lys Asp Tyr Leu Ala Ala Ile Ala 225 230 <210> 16 <211> 297 <212> PRT <213> Homo sapiens <400> 16 Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr 1 5 10 15 Gln Val Lys Phe Arg Arg Arg Arg Glu Gly Lys Thr Asp Tyr Tyr Ala 20 25 30 Arg Lys Arg Leu Val Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys 35 40 45 Tyr Arg Met Ile Val Arg Val Thr Asn Arg Asp Ile Ile Cys Gln Ile 50 55 60 Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala 65 70 75 80 His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala 85 90 95 Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg 100 105 110 Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp 115 120 125 Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys 130 135 140 Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe 145 150 155 160 Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser 165 170 175 Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala 180 185 190 Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met 195 200 205 Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser 210 215 220 Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr 225 230 235 240 Lys Lys Ala His Ala Ala Ile Arg Glu Asn Pro Val Tyr Glu Lys Lys 245 250 255 Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met Ser 260 265 270 Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe Leu 275 280 285 Arg Ala Gln Glu Arg Ala Ala Glu Ser 290 295 <210> 17 <211> 151 <212> PRT <213> Homo sapiens <400> 17 Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe 1 5 10 15 Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys 20 25 30 Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val 35 40 45 Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val 50 55 60 Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn 65 70 75 80 Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe 85 90 95 Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val 100 105 110 Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu 115 120 125 Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe 130 135 140 Val Arg His Ile Leu Ser Gly 145 150 <210> 18 <211> 339 <212> PRT <213> Homo sapiens <400> 18 Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 1 5 10 15 Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 20 25 30 Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 35 40 45 Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 50 55 60 Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 65 70 75 80 Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 85 90 95 Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 100 105 110 Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 115 120 125 Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 130 135 140 Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 145 150 155 160 Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 165 170 175 Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 180 185 190 Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 195 200 205 Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 210 215 220 Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 225 230 235 240 Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 245 250 255 Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 260 265 270 Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 275 280 285 Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 290 295 300 Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 305 310 315 320 Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 325 330 335 Glu Lys Ile <210> 19 <211> 573 <212> PRT <213> Homo sapiens <400> 19 Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 1 5 10 15 Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 20 25 30 Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 35 40 45 Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 50 55 60 Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 65 70 75 80 Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 85 90 95 Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 100 105 110 Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 115 120 125 Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 130 135 140 Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 145 150 155 160 Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 165 170 175 Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 180 185 190 Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 195 200 205 Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 210 215 220 Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 225 230 235 240 Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 245 250 255 Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 260 265 270 Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 275 280 285 Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 290 295 300 Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 305 310 315 320 Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 325 330 335 Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 340 345 350 Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 355 360 365 Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 370 375 380 Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 385 390 395 400 Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 405 410 415 Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 420 425 430 Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 435 440 445 Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 450 455 460 Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 465 470 475 480 Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 485 490 495 Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 500 505 510 Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 515 520 525 Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 530 535 540 Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 545 550 555 560 Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 565 570 <210> 20 <211> 390 <212> PRT <213> Homo sapiens <400> 20 Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr 1 5 10 15 Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala 20 25 30 Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln 35 40 45 Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala 50 55 60 Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala 65 70 75 80 Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu 85 90 95 Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu 100 105 110 Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu 115 120 125 Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu 130 135 140 Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val 145 150 155 160 Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu 165 170 175 Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro 180 185 190 Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu 195 200 205 Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser 210 215 220 Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys 225 230 235 240 Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg 245 250 255 Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys 260 265 270 Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu 275 280 285 Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp 290 295 300 His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro 305 310 315 320 Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu 325 330 335 Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly 340 345 350 Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp 355 360 365 Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val 370 375 380 Asp Lys Ser Asp Ser Asp 385 390 <210> 21 <211> 461 <212> PRT <213> Homo sapiens <400> 21 Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 1 5 10 15 Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 20 25 30 Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 35 40 45 Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 50 55 60 Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 65 70 75 80 Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 85 90 95 Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 100 105 110 Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 115 120 125 Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 130 135 140 Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 145 150 155 160 Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 165 170 175 Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 180 185 190 Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 195 200 205 Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 210 215 220 Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 225 230 235 240 Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 245 250 255 Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 260 265 270 Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 275 280 285 Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 290 295 300 Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 305 310 315 320 Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 325 330 335 Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 340 345 350 Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 355 360 365 Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 370 375 380 Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 385 390 395 400 Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 405 410 415 Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 420 425 430 Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 435 440 445 Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 450 455 460 <210> 22 <211> 645 <212> PRT <213> Homo sapiens <400> 22 Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 1 5 10 15 Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 20 25 30 Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 35 40 45 Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 50 55 60 Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 65 70 75 80 Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 85 90 95 Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 100 105 110 Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 115 120 125 Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 130 135 140 Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 145 150 155 160 Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 165 170 175 Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 180 185 190 Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 195 200 205 Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 210 215 220 Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 225 230 235 240 Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 245 250 255 Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 260 265 270 Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 275 280 285 Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 290 295 300 Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 305 310 315 320 Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 325 330 335 His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 340 345 350 Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 355 360 365 Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 370 375 380 Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 385 390 395 400 Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 405 410 415 Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 420 425 430 Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 435 440 445 Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 450 455 460 Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 465 470 475 480 Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 485 490 495 Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 500 505 510 Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 515 520 525 Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 530 535 540 Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 545 550 555 560 Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Tyr Lys Gly Gln Lys 565,570,575 Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 580,585,590 Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 595,600,605 Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 610 615 620 Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 625 630 635 640 Thr Lys Glu Glu 645 <210> 23 <211> 508 <212> PRT <213> Homo sapiens <400> 23 Met Leu Arg Arg Ala Leu Leu Cys Leo Wing Val Ala Ala Leu Val Arg 1 5 10 15 Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 20 25 30 Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Val Glu Phe 35 40 45 Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 50 55 60 Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 65 70 75 80 Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 85 90 95 Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 100 105 110 Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 115 120 125 Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 130 135 140 Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 145 150 155 160 Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 165 170 175 Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 180 185 190 Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 195 200 205 Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 210 215 220 Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 225 230 235 240 Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 245 250 255 Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 260 265 270 Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 275 280 285 Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 290 295 300 Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 305 310 315 320 Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 325 330 335 Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 340 345 350 Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 355 360 365 Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 370 375 380 Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 385 390 395 400 Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 405 410 415 His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 420 425 430 Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 435 440 445 Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 450 455 460 Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 465 470 475 480 Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 485 490 495 Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 500 505 <210> 24 <211> 911 <212> PRT <213> Homo sapiens <400> 24 Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 1 5 10 15 Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 20 25 30 Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 35 40 45 Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 50 55 60 Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 65 70 75 80 Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 85 90 95 Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 100 105 110 Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 115 120 125 Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 130 135 140 Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 145 150 155 160 Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 165 170 175 Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 180 185 190 Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 195 200 205 Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 210 215 220 Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 225 230 235 240 Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 245 250 255 Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 260 265 270 Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 275 280 285 Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 290 295 300 Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 305 310 315 320 Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 325 330 335 Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 340 345 350 Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 355 360 365 Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 370 375 380 Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 385 390 395 400 Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 405 410 415 Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 420 425 430 Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 435 440 445 Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 450 455 460 Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 465 470 475 480 Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 485 490 495 Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 500 505 510 Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 515 520 525 Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 530 535 540 Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 545 550 555 560 Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 565 570 575 Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 580 585 590 Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 595 600 605 Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 610 615 620 Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 625 630 635 640 Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 645 650 655 Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 660 665 670 Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 675 680 685 His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 690 695 700 Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 705 710 715 720 Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 725 730 735 Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 740 745 750 Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 755 760 765 Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 770 775 780 Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 785 790 795 800 Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 805 810 815 Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 820 825 830 Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 835 840 845 Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala 850 855 860 Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 865 870 875 880 Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 885 890 895 Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 900 905 910 <210> 25 <211> 281 <212> PRT <213> Homo sapiens <400> 25 Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe 1 5 10 15 Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro 20 25 30 Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg 35 40 45 Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser 50 55 60 Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu 65 70 75 80 Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly 85 90 95 Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu 100 105 110 Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln 115 120 125 Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys 130 135 140 Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe 145 150 155 160 Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu 165 170 175 Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu 180 185 190 Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu 195 200 205 Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp 210 215 220 Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile 225 230 235 240 Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr 245 250 255 Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser 260 265 270 Val Asp Ile Ala Ala Phe Asn Lys Ile 275 280 <210> 26 <211> 286 <212> PRT <213> Homo sapiens <400> 26 Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr 1 5 10 15 Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg 20 25 30 Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly 35 40 45 Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly 50 55 60 Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala 65 70 75 80 Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys 85 90 95 Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe 100 105 110 Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp 115 120 125 Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp 130 135 140 Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly 145 150 155 160 Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile 165 170 175 Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val 180 185 190 Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile 195 200 205 Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu 210 215 220 Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln 225 230 235 240 Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys 245 250 255 Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala 260 265 270 Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln 275 280 285 <210> 27 <211> 148 <212> PRT <213> Homo sapiens <400> 27 Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His 1 5 10 15 Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg 20 25 30 Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val 35 40 45 Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met 50 55 60 Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln 65 70 75 80 Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp 85 90 95 Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly 100 105 110 Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln 115 120 125 Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr 130 135 140 Lys Glu Lys Glu 145 <210> 28 <211> 276 <212> PRT <213> Homo sapiens <400> 28 Met Ala Leu Leu Asp Val Cys Gly Ala Pro Arg Gly Gln Arg Pro Glu 1 5 10 15 Ser Ala Leu Pro Val Ala Gly Ser Gly Arg Arg Ser Asp Pro Gly His 20 25 30 Tyr Ser Phe Ser Met Arg Ser Pro Glu Leu Ala Leu Pro Arg Gly Met 35 40 45 Gln Pro Thr Glu Phe Phe Gln Ser Leu Gly Gly Asp Gly Glu Arg Asn 50 55 60 Val Gln Ile Glu Met Ala His Gly Thr Thr Thr Leu Ala Phe Lys Phe 65 70 75 80 Gln His Gly Val Ile Ala Ala Val Asp Ser Arg Ala Ser Ala Gly Ser 85 90 95 Tyr Ile Ser Ala Leu Arg Val Asn Lys Val Ile Glu Ile Asn Pro Tyr 100 105 110 Leu Leu Gly Thr Met Ser Gly Cys Ala Ala Asp Cys Gln Tyr Trp Glu 115 120 125 Arg Leu Leu Ala Lys Glu Cys Arg Leu Tyr Tyr Leu Arg Asn Gly Glu 130 135 140 Arg Ile Ser Val Ser Ala Ala Ser Lys Leu Leu Ser Asn Met Met Cys 145 150 155 160 Gln Tyr Arg Gly Met Gly Leu Ser Met Gly Ser Met Ile Cys Gly Trp 165 170 175 Asp Lys Lys Gly Pro Gly Leu Tyr Tyr Val Asp Glu His Gly Thr Arg 180 185 190 Leu Ser Gly Asn Met Phe Ser Thr Gly Ser Gly Asn Thr Tyr Ala Tyr 195 200 205 Gly Val Met Asp Ser Gly Tyr Arg Pro Asn Leu Ser Pro Glu Glu Ala 210 215 220 Tyr Asp Leu Gly Arg Arg Ala Ile Ala Tyr Ala Thr His Arg Asp Ser 225 230 235 240 Tyr Ser Gly Gly Val Val Asn Met Tyr His Met Lys Glu Asp Gly Trp 245 250 255 Val Lys Val Glu Ser Thr Asp Val Ser Asp Leu Leu His Gln Tyr Arg 260 265 270 Glu Ala Asn Gln 275 <210> 29 <211> 524 <212> PRT <213> Homo sapiens <400> 29 Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 1 5 10 15 Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 20 25 30 Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 35 40 45 Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 50 55 60 Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 65 70 75 80 Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 85 90 95 Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 100 105 110 Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 115 120 125 Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 130 135 140 Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 145 150 155 160 Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 165 170 175 Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 180 185 190 Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 195 200 205 Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 210 215 220 His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 225 230 235 240 Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 245 250 255 Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp 260 265 270 Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala 275 280 285 Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys 290 295 300 His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe 305 310 315 320 Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys 325 330 335 Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser 340 345 350 Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile 355 360 365 Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met 370 375 380 Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val 385 390 395 400 Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val 405 410 415 Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile 420 425 430 Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln 435 440 445 Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu 450 455 460 Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly 465 470 475 480 Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile 485 490 495 Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys 500 505 510 Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 515 520 <210> 30 <211> 277 <212> PRT <213> Homo sapiens <400> 30 Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe 1 5 10 15 Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg 20 25 30 Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly 35 40 45 Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr 50 55 60 Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile 65 70 75 80 Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp 85 90 95 Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser 100 105 110 Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln 115 120 125 Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly 130 135 140 Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly 145 150 155 160 Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala 165 170 175 Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu 180 185 190 Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn 195 200 205 Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn 210 215 220 Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr 225 230 235 240 Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr 245 250 255 Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln 260 265 270 Thr Met Asp Thr Ser 275 <210> 31 <211> 286 <212> PRT <213> Homo sapiens <400> 31 Met Ala Asp Phe Asp Asp Arg Val Ser Asp Glu Glu Lys Val Arg Ile 1 5 10 15 Ala Ala Lys Phe Ile Thr His Ala Pro Pro Gly Glu Phe Asn Glu Val 20 25 30 Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 35 40 45 Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Met Asp Gln Phe Thr Pro 50 55 60 Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 65 70 75 80 Asp Leu Gly Asn Ser Arg Phe Leu Asp Pro Arg Asn Lys Ile Ser Phe 85 90 95 Lys Phe Asp His Leu Arg Lys Glu Ala Ser Asp Pro Gln Pro Glu Glu 100 105 110 Ala Asp Gly Gly Leu Lys Ser Trp Arg Glu Ser Cys Asp Ser Ala Leu 115 120 125 Arg Ala Tyr Val Lys Asp His Tyr Ser Asn Gly Phe Cys Thr Val Tyr 130 135 140 Ala Lys Thr Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 145 150 155 160 His Gln Phe Gln Pro Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 165 170 175 Trp Lys Phe Thr Ile Thr Pro Pro Thr Ala Gln Val Val Gly Val Leu 180 185 190 Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 195 200 205 His Lys Asp Val Gln Asp Ser Leu Thr Val Ser Asn Glu Ala Gln Thr 210 215 220 Ala Lys Glu Phe Ile Lys Ile Ile Glu Asn Ala Glu Asn Glu Tyr Gln 225 230 235 240 Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 245 250 255 Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 260 265 270 Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 275 280 285 <210> 32 <211> 199 <212> PRT <213> Homo sapiens <400> 32 Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 1 5 10 15 Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 20 25 30 Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 35 40 45 Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 50 55 60 Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 65 70 75 80 His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 85 90 95 Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 100 105 110 Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 115 120 125 Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 130 135 140 Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 145 150 155 160 Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 165 170 175 Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 180 185 190 Glu Tyr Phe Ser Lys Gln Lys 195 <210> 33 <211> 613 <212> PRT <213> Homo sapiens <400> 33 Met Ala Gln Ser Arg Val Leu Leu Leu Leu Leu Leu Leu Pro Pro Gln 1 5 10 15 Leu His Leu Gly Pro Val Leu Ala Val Arg Ala Pro Gly Phe Gly Arg 20 25 30 Ser Gly Gly His Ser Leu Ser Pro Glu Glu Asn Glu Phe Ala Glu Glu 35 40 45 Glu Pro Val Leu Val Leu Ser Pro Glu Glu Pro Gly Pro Gly Pro Ala 50 55 60 Ala Val Ser Cys Pro Arg Asp Cys Ala Cys Ser Gln Glu Gly Val Val 65 70 75 80 Asp Cys Gly Gly Ile Asp Leu Arg Glu Phe Pro Gly Asp Leu Pro Glu 85 90 95 His Thr Asn His Leu Ser Leu Gln Asn Asn Gln Leu Glu Lys Ile Tyr 100 105 110 Pro Glu Glu Leu Ser Arg Leu His Arg Leu Glu Thr Leu Asn Leu Gln 115 120 125 Asn Asn Arg Leu Thr Ser Arg Gly Leu Pro Glu Lys Ala Phe Glu His 130 135 140 Leu Thr Asn Leu Asn Tyr Leu Tyr Leu Ala Asn Asn Lys Leu Thr Leu 145 150 155 160 Ala Pro Arg Phe Leu Pro Asn Ala Leu Ile Ser Val Asp Phe Ala Ala 165 170 175 Asn Tyr Leu Thr Lys Ile Tyr Gly Leu Thr Phe Gly Gln Lys Pro Asn 180 185 190 Leu Arg Ser Val Tyr Leu His Asn Asn Lys Leu Ala Asp Ala Gly Leu 195 200 205 Pro Asp Asn Met Phe Asn Gly Ser Ser Asn Val Glu Val Leu Ile Leu 210 215 220 Ser Ser Asn Phe Leu Arg His Val Pro Lys His Leu Pro Pro Ala Leu 225 230 235 240 Tyr Lys Leu His Leu Lys Asn Asn Lys Leu Glu Lys Ile Pro Pro Gly 245 250 255 Ala Phe Ser Glu Leu Ser Ser Leu Arg Glu Leu Tyr Leu Gln Asn Asn 260 265 270 Tyr Leu Thr Asp Glu Gly Leu Asp Asn Glu Thr Phe Trp Lys Leu Ser 275 280 285 Ser Leu Glu Tyr Leu Asp Leu Ser Ser Asn Asn Leu Ser Arg Val Pro 290 295 300 Ala Gly Leu Pro Arg Ser Leu Val Leu Leu His Leu Glu Lys Asn Ala 305 310 315 320 Ile Arg Ser Val Asp Ala Asn Val Leu Thr Pro Ile Arg Ser Leu Glu 325 330 335 Tyr Leu Leu Leu His Ser Asn Gln Leu Arg Glu Gln Gly Ile His Pro 340 345 350 Leu Ala Phe Gln Gly Leu Lys Arg Leu His Thr Val His Leu Tyr Asn 355 360 365 Asn Ala Leu Glu Arg Val Pro Ser Gly Leu Pro Arg Arg Val Arg Thr 370 375 380 Leu Met Ile Leu His Asn Gln Ile Thr Gly Ile Gly Arg Glu Asp Phe 385 390 395 400 Ala Thr Thr Tyr Phe Leu Glu Glu Leu Asn Leu Ser Tyr Asn Arg Ile 405 410 415 Thr Ser Pro Gln Val His Arg Asp Ala Phe Arg Lys Leu Arg Leu Leu 420 425 430 Arg Ser Leu Asp Leu Ser Gly Asn Arg Leu His Thr Leu Pro Pro Gly 435 440 445 Leu Pro Arg Asn Val His Val Leu Lys Val Lys Arg Asn Glu Leu Ala 450 455 460 Ala Leu Ala Arg Gly Ala Leu Val Gly Met Ala Gln Leu Arg Glu Leu 465 470 475 480 Tyr Leu Thr Ser Asn Arg Leu Arg Ser Arg Ala Leu Gly Pro Arg Ala 485 490 495 Trp Val Asp Leu Ala His Leu Gln Leu Leu Asp Ile Ala Gly Asn Gln 500 505 510 Leu Thr Glu Ile Pro Glu Gly Leu Pro Glu Ser Leu Glu Tyr Leu Tyr 515 520 525 Leu Gln Asn Asn Lys Ile Ser Ala Val Pro Ala Asn Ala Phe Asp Ser 530 535 540 Thr Pro Asn Leu Lys Gly Ile Phe Leu Arg Phe Asn Lys Leu Ala Val 545 550 555 560 Gly Ser Val Val Asp Ser Ala Phe Arg Arg Leu Lys His Leu Gln Val 565 570 575 Leu Asp Ile Glu Gly Asn Leu Glu Phe Gly Asp Ile Ser Lys Asp Arg 580 585 590 Gly Arg Leu Gly Lys Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu 595 600 605 Glu Glu Glu Thr Arg 610 <210> 34 <211> 469 <212> PRT <213> Homo sapiens <400> 34 Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 1 5 10 15 Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 20 25 30 Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 35 40 45 Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 50 55 60 Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 65 70 75 80 Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 85 90 95 Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 100 105 110 His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 115 120 125 Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 130 135 140 Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 145 150 155 160 Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 165 170 175 Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 180 185 190 Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 195 200 205 Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 210 215 220 Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 225 230 235 240 Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 245 250 255 Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 260 265 270 Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 275 280 285 Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 290 295 300 Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 305 310 315 320 Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 325 330 335 Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 340 345 350 Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 355 360 365 Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 370 375 380 Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 385 390 395 400 Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 405 410 415 His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 420 425 430 Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 435 440 445 Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 450 455 460 Asn Cys Arg Lys Asn 465 <210> 35 <211> 420 <212> PRT <213> Homo sapiens <400> 35 Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 1 5 10 15 Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 20 25 30 Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 35 40 45 Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 50 55 60 Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 65 70 75 80 Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 85 90 95 His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 100 105 110 Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 115 120 125 Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 130 135 140 Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 145 150 155 160 Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 165 170 175 Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 180 185 190 Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 195 200 205 Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 210 215 220 Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 225 230 235 240 Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 245 250 255 Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 260 265 270 Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 275 280 285 Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Ser Glu 290 295 300 Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 305 310 315 320 Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 325 330 335 Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 340 345 350 Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 355 360 365 Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 370 375 380 Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 385 390 395 400 Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 405 410 415 Glu Pro His Ile 420 <210> 36 <211> 215 <212> PRT <213> Homo sapiens <400> 36 Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 1 5 10 15 Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 20 25 30 Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 35 40 45 Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 50 55 60 Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 65 70 75 80 Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 85 90 95 Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 100 105 110 Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 115 120 125 Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 130 135 140 Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 145 150 155 160 Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 165 170 175 Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 180 185 190 Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 195 200 205 Glu Glu Asp Asp Asp Asp Glu 210 215 <210> 37 <211> 5890 <212> PRT <213> Homo sapiens <400> 37 Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 1 5 10 15 Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 20 25 30 Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 35 40 45 Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 50 55 60 Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 65 70 75 80 Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 85 90 95 Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 100 105 110 Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 115 120 125 Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 130 135 140 Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 145 150 155 160 Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 165 170 175 Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 180 185 190 Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 195 200 205 Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 210 215 220 Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 225 230 235 240 His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 245 250 255 Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 260 265 270 Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 275 280 285 Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 290 295 300 Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 305 310 315 320 Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 325 330 335 Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 340 345 350 Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 355 360 365 Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 370 375 380 Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 385 390 395 400 Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 405 410 415 Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 420 425 430 Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 435 440 445 Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 450 455 460 Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 465 470 475 480 Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 485 490 495 Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 500 505 510 Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 515 520 525 Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 530 535 540 Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 545 550 555 560 Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 565 570 575 Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 580 585 590 Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 595 600 605 Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 610 615 620 Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 625 630 635 640 Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 645 650 655 Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 660 665 670 Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 675 680 685 Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 690 695 700 His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 705 710 715 720 Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 725 730 735 Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 740 745 750 Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 755 760 765 Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 770 775 780 Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 785 790 795 800 Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 805 810 815 Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 820 825 830 Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 835 840 845 Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 850 855 860 Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 865 870 875 880 Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 885 890 895 Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 900 905 910 Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 915 920 925 Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 930 935 940 Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 945 950 955 960 Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 965 970 975 Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 980 985 990 Asp Trp Asn Leu Lys Met Pro Lys Ile Lys Met Pro Lys Phe Ser Met 995 1000 1005 Pro Ser Leu Lys Gly Glu Gly Pro Glu Phe Asp Val Asn Leu Ser 1010 1015 1020 Lys Ala Asn Val Asp Ile Ser Ala Pro Lys Val Asp Thr Asn Ala 1025 1030 1035 Pro Asp Leu Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro 1040 1045 1050 Lys Phe Lys Met Pro Glu Met His Phe Arg Ala Pro Lys Met Ser 1055 1060 1065 Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Met Lys Gly 1070 1075 1080 Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu Met Gln Val 1085 1090 1095 Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys Ala Pro 1100 1105 1110 Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro Lys 1115 1120 1125 Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly 1130 1135 1140 Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Val Val Ser 1145 1150 1155 Gly Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly 1160 1165 1170 Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met 1175 1180 1185 His Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His 1190 1195 1200 Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Val Pro 1205 1210 1215 Lys Val Glu Gly Glu Met Lys Val Pro Asp Val Glu Ile Lys Gly 1220 1225 1230 Pro Lys Met Asp Ile Asp Ala Pro Asp Val Glu Val Gln Gly Pro 1235 1240 1245 Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser 1250 1255 1260 Met Pro Gly Phe Lys Gly Glu Gly Arg Glu Val Asp Val Asn Leu 1265 1270 1275 Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Glu 1280 1285 1290 Val Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly 1295 1300 1305 Pro Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile 1310 1315 1320 Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys 1325 1330 1335 Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu Met Lys 1340 1345 1350 Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser Ala 1355 1360 1365 Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro 1370 1375 1380 Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu 1385 1390 1395 Gly Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val 1400 1405 1410 Ser Gly Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu 1415 1420 1425 Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu 1430 1435 1440 Met Ser Ile Lys Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu 1445 1450 1455 His Leu Lys Gly Pro Lys Met Lys Gly Asp Tyr Asp Val Thr Val 1460 1465 1470 Pro Lys Val Glu Gly Glu Ile Lys Ala Pro Asp Val Asp Ile Lys 1475 1480 1485 Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Glu Val His Gly 1490 1495 1500 Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe 1505 1510 1515 Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Met Asn 1520 1525 1530 Leu Pro Lys Ala Asp Leu Gly Val Ser Gly Pro Lys Val Asp Ile 1535 1540 1545 Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu Gly Lys Leu Lys 1550 1555 1560 Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln Thr His Lys 1565 1570 1575 Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro Lys Leu 1580 1585 1590 Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu 1595 1600 1605 Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn 1610 1615 1620 Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly 1625 1630 1635 Pro Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile 1640 1645 1650 Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys 1655 1660 1665 Gly Asp Met Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys 1670 1675 1680 Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala 1685 1690 1695 Pro Asp Val Glu Val His Asp Pro Asp Trp His Leu Lys Met Pro 1700 1705 1710 Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu 1715 1720 1725 Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val 1730 1735 1740 Ser Gly Pro Ser Val Asp Thr Asp Ala Pro Asp Leu Asp Ile Glu 1745 1750 1755 Gly Pro Glu Gly Lys Leu Lys Gly Ser Lys Phe Lys Met Pro Lys 1760 1765 1770 Leu Asn Ile Lys Ala Pro Lys Val Ser Met Pro Asp Val Asp Leu 1775 1780 1785 Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile Asp Ala Ser Val 1790 1795 1800 Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val Asp Val Lys 1805 1810 1815 Gly Pro Phe Val Glu Ala Glu Val Pro Asp Val Asp Leu Glu Cys 1820 1825 1830 Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met 1835 1840 1845 His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His 1850 1855 1860 Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro 1865 1870 1875 Lys Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val 1880 1885 1890 Pro Asp Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro 1895 1900 1905 Lys Phe Lys Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser 1910 1915 1920 Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly 1925 1930 1935 Asp Val Asp Val Ser Val Pro Lys Leu Glu Gly Asp Leu Thr Gly 1940 1945 1950 Pro Ser Val Gly Val Glu Val Pro Asp Val Glu Leu Glu Cys Pro 1955 1960 1965 Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His 1970 1975 1980 Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu 1985 1990 1995 Lys Gly Pro Lys Val Lys Gly Asp Met Asp Val Ser Val Pro Lys 2000 2005 2010 Val Glu Gly Glu Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro 2015 2020 2025 Lys Met Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp 2030 2035 2040 Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met 2045 2050 2055 Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro 2060 2065 2070 Lys Ala Asp Val Val Val Ser Gly Pro Lys Val Asp Val Glu Val 2075 2080 2085 Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro 2090 2095 2100 Lys Leu Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser 2105 2110 2115 Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly 2120 2125 2130 Asp Val Asp Val Ser Leu Pro Lys Leu Glu Gly Asp Leu Thr Gly 2135 2140 2145 Pro Ser Val Asp Val Glu Val Pro Asp Val Glu Leu Glu Cys Pro 2150 2155 2160 Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His 2165 2170 2175 Phe Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asn Leu Asn Leu 2180 2185 2190 Lys Gly Pro Lys Val Lys Gly Asp Met Asp Val Ser Val Pro Lys 2195 2200 2205 Val Glu Gly Glu Met Lys Val Pro Asp Val Asp Ile Arg Gly Pro 2210 2215 2220 Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp 2225 2230 2235 Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met 2240 2245 2250 Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Val Asn Leu Pro 2255 2260 2265 Lys Ala Asp Val Asp Val Ser Gly Pro Lys Val Asp Val Glu Val 2270 2275 2280 Pro Asp Val Ser Leu Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro 2285 2290 2295 Lys Phe Lys Met Pro Glu Met His Phe Lys Thr Pro Lys Ile Ser 2300 2305 2310 Met Pro Asp Val Asp Phe Asn Leu Lys Gly Pro Lys Ile Lys Gly 2315 2320 2325 Asp Val Asp Val Ser Ala Pro Lys Leu Glu Gly Glu Leu Lys Gly 2330 2335 2340 Pro Glu Leu Asp Val Lys Gly Pro Lys Leu Asp Ala Asp Met Pro 2345 2350 2355 Glu Val Ala Val Glu Gly Pro Asn Gly Lys Trp Lys Thr Pro Lys 2360 2365 2370 Phe Lys Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met 2375 2380 2385 Pro Asp Leu Asp Leu His Leu Lys Ser Pro Lys Ala Lys Gly Glu 2390 2395 2400 Val Asp Val Asp Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro 2405 2410 2415 His Val Asp Val Ser Gly Pro Asp Ile Asp Ile Glu Gly Pro Glu 2420 2425 2430 Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Asp Met His Phe 2435 2440 2445 Lys Ala Pro Asn Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys 2450 2455 2460 Gly Pro Lys Ile Lys Gly Asp Val Asp Val Ser Val Pro Glu Val 2465 2470 2475 Glu Gly Lys Leu Glu Val Pro Asp Met Asn Ile Arg Gly Pro Lys 2480 2485 2490 Val Asp Val Asn Ala Pro Asp Val Gln Ala Pro Asp Trp His Leu 2495 2500 2505 Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe 2510 2515 2520 Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp 2525 2530 2535 Val Asp Ile Ser Gly Pro Lys Val Asp Ile Glu Gly Pro Asp Val 2540 2545 2550 Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Leu Lys 2555 2560 2565 Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp 2570 2575 2580 Phe Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp 2585 2590 2595 Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val 2600 2605 2610 Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Gly 2615 2620 2625 Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met 2630 2635 2640 Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Gly 2645 2650 2655 Asp Val Lys Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys 2660 2665 2670 Val Asp Ile Glu Gly Pro Asp Val Asn Ile Glu Gly Pro Glu Gly 2675 2680 2685 Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys 2690 2695 2700 Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly 2705 2710 2715 Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu 2720 2725 2730 Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val 2735 2740 2745 Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His 2750 2755 2760 Leu Lys Met Pro Lys Ile Lys Met Pro Lys Ile Ser Met Pro Gly 2765 2770 2775 Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala 2780 2785 2790 Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Glu Cys Pro Asp 2795 2800 2805 Val Asn Ile Glu Gly Pro Glu Gly Lys Trp Lys Ser Pro Lys Phe 2810 2815 2820 Lys Met Pro Glu Met His Phe Lys Thr Pro Lys Ile Ser Met Pro 2825 2830 2835 Asp Ile Asp Leu Asn Leu Thr Gly Pro Lys Ile Lys Gly Asp Val 2840 2845 2850 Asp Val Thr Gly Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu 2855 2860 2865 Val Asp Leu Lys Gly Pro Lys Val Asp Ile Asp Val Pro Asp Val 2870 2875 2880 Asn Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met Lys 2885 2890 2895 Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 2900 2905 2910 Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly Pro 2915 2920 2925 Lys Val Asp Val Glu Gly Pro Asp Val Asn Ile Glu Gly Pro Glu 2930 2935 2940 Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile 2945 2950 2955 Lys Ala Pro Lys Ile Pro Met Pro Asp Phe Asp Leu His Leu Lys 2960 2965 2970 Gly Pro Lys Val Lys Gly Asp Val Asp Ile Ser Leu Pro Lys Val 2975 2980 2985 Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Arg Gly Pro Gln 2990 2995 3000 Val Asp Ile Asp Val Pro Asp Val Gly Val Gln Gly Pro Asp Trp 3005 3010 3015 His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro 3020 3025 3030 Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys 3035 3040 3045 Ala Asp Leu Asp Val Ser Gly Pro Lys Val Asp Ile Asp Val Pro 3050 3055 3060 Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys 3065 3070 3075 Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met 3080 3085 3090 Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp 3095 3100 3105 Met Asp Val Ser Leu Pro Lys Val Glu Gly Asp Met Lys Val Pro 3110 3115 3120 Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala Pro Asp 3125 3130 3135 Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Ile 3140 3145 3150 Lys Met Pro Lys Ile Ser Met Pro Gly Phe Lys Gly Glu Gly Pro 3155 3160 3165 Glu Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val Ser Gly 3170 3175 3180 Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu Gly Pro 3185 3190 3195 Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn 3200 3205 3210 Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Leu Asp Leu Asn Leu 3215 3220 3225 Lys Gly Pro Lys Met Lys Gly Glu Val Asp Val Ser Leu Ala Asn 3230 3235 3240 Val Glu Gly Asp Leu Lys Gly Pro Ala Leu Asp Ile Lys Gly Pro 3245 3250 3255 Lys Ile Asp Val Asp Ala Pro Asp Ile Asp Ile His Gly Pro Asp 3260 3265 3270 Ala Lys Leu Lys Gly Pro Lys Leu Lys Met Pro Asp Met His Val 3275 3280 3285 Asn Met Pro Lys Ile Ser Met Pro Glu Ile Asp Leu Asn Leu Lys 3290 3295 3300 Gly Ser Lys Leu Lys Gly Asp Val Asp Val Ser Gly Pro Lys Leu 3305 3310 3315 Glu Gly Asp Ile Lys Ala Pro Ser Leu Asp Ile Lys Gly Pro Glu 3320 3325 3330 Val Asp Val Ser Gly Pro Lys Leu Asn Ile Glu Gly Lys Ser Lys 3335 3340 3345 Lys Ser Arg Phe Lys Leu Pro Lys Phe Asn Phe Ser Gly Ser Lys 3350 3355 3360 Val Gln Thr Pro Glu Val Asp Val Lys Gly Lys Lys Pro Asp Ile 3365 3370 3375 Asp Ile Thr Gly Pro Lys Val Asp Ile Asn Ala Pro Asp Val Glu 3380 3385 3390 Val Gln Gly Lys Val Lys Gly Ser Lys Phe Lys Met Pro Phe Leu 3395 3400 3405 Ser Ile Ser Ser Pro Lys Val Ser Met Pro Asp Val Glu Leu Asn 3410 3415 3420 Leu Lys Ser Pro Lys Val Lys Gly Asp Leu Asp Ile Ala Gly Pro 3425 3430 3435 Asn Leu Glu Gly Asp Phe Lys Gly Pro Lys Val Asp Ile Lys Ala 3440 3445 3450 Pro Glu Val Asn Leu Asn Ala Pro Asp Val Asp Val His Gly Pro 3455 3460 3465 Asp Trp Asn Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser 3470 3475 3480 Val Ser Gly Leu Lys Ala Glu Gly Pro Asp Val Ala Val Asp Leu 3485 3490 3495 Pro Lys Gly Asp Ile Asn Ile Glu Gly Pro Ser Met Asn Ile Glu 3500 3505 3510 Gly Pro Asp Leu Asn Val Glu Gly Pro Glu Gly Gly Leu Lys Gly 3515 3520 3525 Pro Lys Phe Lys Met Pro Asp Met Asn Ile Lys Ala Pro Lys Ile 3530 3535 3540 Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys 3545 3550 3555 Gly Asp Val Asp Ile Ser Leu Pro Lys Leu Glu Gly Asp Leu Lys 3560 3565 3570 Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala 3575 3580 3585 Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro 3590 3595 3600 Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu 3605 3610 3615 Gly Pro Glu Val Asp Val Thr Leu Pro Lys Ala Asp Ile Asp Ile 3620 3625 3630 Ser Gly Pro Asn Val Asp Val Asp Val Pro Asp Val Asn Ile Glu 3635 3640 3645 Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu 3650 3655 3660 Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp Leu 3665 3670 3675 Asn Leu Lys Gly Pro Lys Met Lys Gly Asp Val Val Val Ser Leu 3680 3685 3690 Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys 3695 3700 3705 Gly Pro Lys Val Asp Ile Asp Thr Pro Asp Ile Asn Ile Glu Gly 3710 3715 3720 Ser Glu Gly Lys Phe Lys Gly Pro Lys Phe Lys Ile Pro Glu Met 3725 3730 3735 His Leu Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn 3740 3745 3750 Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu Pro 3755 3760 3765 Lys Met Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile Lys Gly 3770 3775 3780 Pro Lys Val Asp Ile Asn Ala Pro Asp Val Asp Val Gln Gly Pro 3785 3790 3795 Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser 3800 3805 3810 Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu 3815 3820 3825 Pro Lys Ala Asp Leu Asp Val Ser Gly Pro Lys Val Asp Ile Asp 3830 3835 3840 Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly 3845 3850 3855 Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile 3860 3865 3870 Ser Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys 3875 3880 3885 Gly Asp Met Asp Val Ser Leu Pro Lys Val Glu Gly Asp Met Gln 3890 3895 3900 Val Pro Asp Leu Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Ala 3905 3910 3915 Pro Asp Val Asp Val Arg Gly Pro Asp Trp His Leu Lys Met Pro 3920 3925 3930 Lys Ile Lys Met Pro Lys Ile Ser Met Pro Gly Phe Lys Gly Glu 3935 3940 3945 Gly Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val 3950 3955 3960 Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu 3965 3970 3975 Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu 3980 3985 3990 Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp Leu 3995 4000 4005 His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser Leu 4010 4015 4020 Pro Lys Met Glu Gly Asp Leu Lys Ala Pro Glu Val Asp Ile Lys 4025 4030 4035 Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly 4040 4045 4050 Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe 4055 4060 4065 Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Glu Val Asp Val Asn 4070 4075 4080 Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Ile 4085 4090 4095 Asp Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu Lys 4100 4105 4110 Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys 4115 4120 4125 Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Met 4130 4135 4140 Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu 4145 4150 4155 Lys Gly Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp 4160 4165 4170 Val Pro Asp Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met 4175 4180 4185 Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly 4190 4195 4200 Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Leu Asp 4205 4210 4215 Val Ser Gly Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Ile 4220 4225 4230 Glu Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro 4235 4240 4245 Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe Asp 4250 4255 4260 Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser 4265 4270 4275 Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Val Asp Ile 4280 4285 4290 Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His 4295 4300 4305 Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys 4310 4315 4320 Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val 4325 4330 4335 Thr Leu Pro Lys Ala Asp Ile Glu Ile Ser Gly Pro Lys Val Asp 4340 4345 4350 Ile Asp Ala Pro Asp Val Ser Ile Glu Gly Pro Asp Ala Lys Leu 4355 4360 4365 Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 4370 4375 4380 Lys Ile Ser Met Pro Asp Ile Asp Phe Asn Leu Lys Gly Pro Lys 4385 4390 4395 Val Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp 4400 4405 4410 Leu Lys Gly Pro Glu Ile Asp Ile Lys Gly Pro Ser Leu Asp Ile 4415 4420 4425 Asp Thr Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys 4430 4435 4440 Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys 4445 4450 4455 Ile Ser Met Pro Asp Phe Asp Leu His Leu Lys Gly Pro Lys Val 4460 4465 4470 Lys Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Ser Asp Leu 4475 4480 4485 Lys Gly Pro Glu Val Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys 4490 4495 4500 Gly Pro Lys Phe Lys Met Pro Asp Val His Phe Lys Ser Pro Gln 4505 4510 4515 Ile Ser Met Ser Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Ile 4520 4525 4530 Lys Gly Asp Met Asp Ile Ser Val Pro Lys Leu Glu Gly Asp Leu 4535 4540 4545 Lys Gly Pro Lys Val Asp Val Lys Gly Pro Lys Val Gly Ile Asp 4550 4555 4560 Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu Lys Gly 4565 4570 4575 Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys Ile 4580 4585 4590 Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Val Lys 4595 4600 4605 Gly Asp Met Asp Ile Ser Leu Pro Lys Val Glu Gly Asp Leu Lys 4610 4615 4620 Gly Pro Glu Val Asp Ile Arg Asp Pro Lys Val Asp Ile Asp Val 4625 4630 4635 Pro Asp Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro 4640 4645 4650 Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu 4655 4660 4665 Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val 4670 4675 4680 Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu 4685 4690 4695 Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu 4700 4705 4710 Met Ser Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu 4715 4720 4725 Asn Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Thr Leu 4730 4735 4740 Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile Lys 4745 4750 4755 Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly 4760 4765 4770 Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe 4775 4780 4785 Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Ser 4790 4795 4800 Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val 4805 4810 4815 Asp Ile Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys 4820 4825 4830 Gly Pro Lys Phe Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys 4835 4840 4845 Ile Ser Ile Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Val 4850 4855 4860 Lys Gly Asp Phe Asp Val Ser Val Pro Lys Val Glu Gly Thr Leu 4865 4870 4875 Lys Gly Pro Glu Val Asp Leu Lys Gly Pro Arg Leu Asp Phe Glu 4880 4885 4890 Gly Pro Asp Ala Lys Leu Ser Gly Pro Ser Leu Lys Met Pro Ser 4895 4900 4905 Leu Glu Ile Ser Ala Pro Lys Val Thr Ala Pro Asp Val Asp Leu 4910 4915 4920 His Leu Lys Ala Pro Lys Ile Gly Phe Ser Gly Pro Lys Leu Glu 4925 4930 4935 Gly Gly Glu Val Asp Leu Lys Gly Pro Lys Val Glu Ala Pro Ser 4940 4945 4950 Leu Asp Val His Met Asp Ser Pro Asp Ile Asn Ile Glu Gly Pro 4955 4960 4965 Asp Val Lys Ile Pro Lys Phe Lys Lys Pro Lys Phe Gly Phe Gly 4970 4975 4980 Ala Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro Ser Leu Asp Val 4985 4990 4995 Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro Glu Ile Ser 5000 5005 5010 Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro Lys Ile 5015 5020 5025 His Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe Asp 5030 5035 5040 Leu Asn Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro 5045 5050 5055 Asp Val Asp Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val 5060 5065 5070 Asp Val Lys Ser Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met 5075 5080 5085 Tyr Phe Pro Asp Val Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys 5090 5095 5100 Ala Glu Ala Pro Leu Pro Ser Pro Lys Leu Glu Gly Glu Leu Gln 5105 5110 5115 Ala Pro Asp Leu Glu Leu Ser Leu Pro Ala Ile His Val Glu Gly 5120 5125 5130 Leu Asp Ile Lys Ala Lys Ala Pro Lys Val Lys Met Pro Asp Val 5135 5140 5145 Asp Ile Ser Val Pro Lys Ile Glu Gly Asp Leu Lys Gly Pro Lys 5150 5155 5160 Val Gln Ala Asn Leu Gly Ala Pro Asp Ile Asn Ile Glu Gly Leu 5165 5170 5175 Asp Ala Lys Val Lys Thr Pro Ser Phe Gly Ile Ser Ala Pro Gln 5180 5185 5190 Val Ser Ile Pro Asp Val Asn Val Asn Leu Lys Gly Pro Lys Ile 5195 5200 5205 Lys Gly Asp Val Pro Ser Val Gly Leu Glu Gly Pro Asp Val Asp 5210 5215 5220 Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro Lys Phe Ser Met 5225 5230 5235 Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly Gly Gly Ala 5240 5245 5250 Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu Arg Gly 5255 5260 5265 Pro Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly Pro 5270 5275 5280 Gly Val Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser 5285 5290 5295 Gly Pro Asp Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly 5300 5305 5310 Asp Leu Asp Ala Ser Val Pro Ser Met Lys Val His Ala Pro Gly 5315 5320 5325 Leu Asn Leu Ser Gly Val Gly Gly Lys Met Gln Val Gly Gly Asp 5330 5335 5340 Gly Val Lys Val Pro Gly Ile Asp Ala Thr Thr Lys Leu Asn Val 5345 5350 5355 Gly Ala Pro Asp Val Thr Leu Arg Gly Pro Ser Leu Gln Gly Asp 5360 5365 5370 Leu Ala Val Ser Gly Asp Ile Lys Cys Pro Lys Val Ser Val Gly 5375 5380 5385 Ala Pro Asp Leu Ser Leu Glu Ala Ser Glu Gly Ser Ile Lys Leu 5390 5395 5400 Pro Lys Met Lys Leu Pro Gln Phe Gly Ile Ser Thr Pro Gly Ser 5405 5410 5415 Asp Leu His Val Asn Ala Lys Gly Pro Gln Val Ser Gly Glu Leu 5420 5425 5430 Lys Gly Pro Gly Val Asp Val Asn Leu Lys Gly Pro Arg Ile Ser 5435 5440 5445 Ala Pro Asn Val Asp Phe Asn Leu Glu Gly Pro Lys Val Lys Gly 5450 5455 5460 Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro Thr Val Gly Gly 5465 5470 5475 Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly Asn Leu Gln 5480 5485 5490 Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu Pro Gly 5495 5500 5505 Val Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu Ile 5510 5515 5520 Lys Gly Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala 5525 5530 5535 Pro Asp Ile Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro 5540 5545 5550 Glu Ser Asp Phe Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly 5555 5560 5565 Gly Ala Asp Val Ser Gly Gly Val Ser Ala Pro Asp Ile Ser Leu 5570 5575 5580 Gly Glu Gly His Leu Ser Val Lys Gly Ser Gly Gly Glu Trp Lys 5585 5590 5595 Gly Pro Gln Val Ser Ser Ala Leu Asn Leu Asp Thr Ser Lys Phe 5600 5605 5610 Ala Gly Gly Leu His Phe Ser Gly Pro Lys Val Glu Gly Gly Val 5615 5620 5625 Lys Gly Gly Gln Ile Gly Leu Gln Ala Pro Gly Leu Ser Val Ser 5630 5635 5640 Gly Pro Gln Gly His Leu Glu Ser Gly Ser Gly Lys Val Thr Phe 5645 5650 5655 Pro Lys Met Lys Ile Pro Lys Phe Thr Phe Ser Gly Arg Glu Leu 5660 5665 5670 Val Gly Arg Glu Met Gly Val Asp Val His Phe Pro Lys Ala Glu 5675 5680 5685 Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly Glu Trp Glu Glu Ser 5690 5695 5700 Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met Pro Lys Phe Asn 5705 5710 5715 Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly Ser Pro Glu 5720 5725 5730 Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser Lys Ala 5735 5740 5745 Ser Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser Ser 5750 5755 5760 Pro Lys Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His 5765 5770 5775 Arg Ser Asn Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser 5780 5785 5790 Thr Pro Thr Gly Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu 5795 5800 5805 Glu Gly Gly Lys Val Lys Gly Lys His Gly Lys Leu Lys Phe Gly 5810 5815 5820 Thr Phe Gly Gly Leu Gly Ser Lys Ser Lys Gly His Tyr Glu Val 5825 5830 5835 Thr Gly Ser Asp Asp Glu Thr Gly Lys Leu Gln Gly Ser Gly Val 5840 5845 5850 Ser Leu Ala Ser Lys Lys Ser Arg Leu Ser Ser Ser Ser Ser Asn 5855 5860 5865 Asp Ser Gly Asn Lys Val Gly Ile Gln Leu Pro Glu Val Glu Leu 5870 5875 5880 Ser Val Ser Thr Lys Lys Glu 5885 5890 <210> 38 <211> 1894 <212> PRT <213> Homo sapiens <400> 38 Met Ala Pro Glu Ala Gly Ala Thr Leu Arg Ala Pro Arg Arg Leu Ser 1 5 10 15 Trp Ala Ala Leu Leu Leu Leu Ala Ala Leu Leu Pro Val Ala Ser Ser 20 25 30 Ala Ala Ala Ser Val Asp His Pro Leu Lys Pro Arg His Val Lys Leu 35 40 45 Leu Ser Thr Lys Met Gly Leu Lys Val Thr Trp Asp Pro Pro Lys Asp 50 55 60 Ala Thr Ser Arg Pro Val Glu His Tyr Asn Ile Ala Tyr Gly Lys Ser 65 70 75 80 Leu Lys Ser Leu Lys Tyr Ile Lys Val Asn Ala Glu Thr Tyr Ser Phe 85 90 95 Leu Ile Glu Asp Val Glu Pro Gly Val Val Tyr Phe Val Leu Leu Thr 100 105 110 Ala Glu Asn His Ser Gly Val Ser Arg Pro Val Tyr Arg Ala Glu Ser 115 120 125 Pro Pro Gly Gly Glu Trp Ile Glu Ile Asp Gly Phe Pro Ile Lys Gly 130 135 140 Pro Gly Pro Phe Asn Glu Thr Val Thr Glu Lys Glu Val Pro Asn Lys 145 150 155 160 Pro Leu Arg Val Arg Val Arg Ser Ser Asp Asp Arg Leu Ser Val Ala 165 170 175 Trp Lys Ala Pro Arg Leu Ser Gly Ala Lys Ser Pro Arg Arg Ser Arg 180 185 190 Gly Phe Leu Leu Gly Tyr Gly Glu Ser Gly Arg Lys Met Asn Tyr Val 195 200 205 Pro Leu Thr Arg Asp Glu Arg Thr His Glu Ile Lys Lys Leu Ala Ser 210 215 220 Glu Ser Val Tyr Val Val Ser Leu Gln Ser Met Asn Ser Gln Gly Arg 225 230 235 240 Ser Gln Pro Val Tyr Arg Ala Ala Leu Thr Lys Arg Lys Ile Ser Glu 245 250 255 Glu Asp Glu Leu Asp Val Pro Asp Asp Ile Ser Val Arg Val Met Ser 260 265 270 Ser Gln Ser Val Leu Val Ser Trp Val Asp Pro Val Leu Glu Lys Gln 275 280 285 Lys Lys Val Val Ala Ser Arg Gln Tyr Thr Val Arg Tyr Arg Glu Lys 290 295 300 Gly Glu Leu Ala Arg Trp Asp Tyr Lys Gln Ile Ala Asn Arg Arg Val 305 310 315 320 Leu Ile Glu Asn Leu Ile Pro Asp Thr Val Tyr Glu Phe Ala Val Arg 325 330 335 Ile Ser Gln Gly Glu Arg Asp Gly Lys Trp Ser Thr Ser Val Phe Gln 340 345 350 Arg Thr Pro Glu Ser Ala Pro Thr Thr Ala Pro Glu Asn Leu Asn Val 355 360 365 Trp Pro Val Asn Gly Lys Pro Thr Val Val Ala Ala Ser Trp Asp Ala 370 375 380 Leu Pro Glu Thr Glu Gly Lys Val Lys Glu Tyr Ile Leu Ser Tyr Ala 385 390 395 400 Pro Ala Leu Lys Pro Phe Gly Ala Lys Ser Leu Thr Tyr Pro Gly Asp 405 410 415 Thr Thr Ser Ala Leu Val Asp Gly Leu Gln Pro Gly Glu Arg Tyr Leu 420 425 430 Phe Lys Ile Arg Ala Thr Asn Arg Arg Gly Leu Gly Pro His Ser Lys 435 440 445 Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp Val Glu Gln 450 455 460 Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro Ser Ser Pro 465 470 475 480 Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val Pro Ala Ser 485 490 495 Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu Lys Asn Lys 500 505 510 Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu Arg Ala Lys 515 520 525 Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr Gly Glu Glu 530 535 540 Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser Asp Thr Gln 545 550 555 560 Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly His Ser Val 565 570 575 Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro Ala Leu Pro 580 585 590 Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala Thr Gln Pro 595 600 605 Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala His His Ala 610 615 620 Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala Ser Leu Asn 625 630 635 640 Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala Val Gly Ser 645 650 655 Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala Leu Ser Pro 660 665 670 Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser Ser Val His 675 680 685 Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro His Ser Gly 690 695 700 Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser Arg Leu Ser 705 710 715 720 Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln Pro His Leu 725 730 735 Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp Ala Pro Ala 740 745 750 Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser Ser Val Ser 755 760 765 Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala Glu Ala Ser 770 775 780 Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly Gly Arg Gln 785 790 795 800 Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala Ser Gly His 805 810 815 Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly Arg Ser Pro 820 825 830 Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro Ser Ser Ser 835 840 845 Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val Pro Ser His 850 855 860 Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly Asp Glu Glu 865 870 875 880 Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His Val Pro Ser 885 890 895 Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu Arg Arg Ser 900 905 910 Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile Pro Glu Asn 915 920 925 Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys Tyr Ser Ser 930 935 940 Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp Ala Asp Thr 945 950 955 960 Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp Arg His Ala 965 970 975 Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His Pro Ser Val 980 985 990 Pro Arg Arg Met Thr Pro Gly Arg Ala Pro Gln Gln Gln Pro Pro Pro 995 1000 1005 Pro Val Ala Thr Ser Gln His His Pro Gly Pro Gln Ser Arg Asp 1010 1015 1020 Ala Gly Arg Ser Pro Ser Gln Pro Arg Leu Ser Leu Thr Gln Ala 1025 1030 1035 Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg Ser His Ser Ser Ser 1040 1045 1050 Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu Pro Thr Ala Leu 1055 1060 1065 Gln Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp Asp Asp Ser 1070 1075 1080 Thr Glu Val Glu Ala Gln Asp Val Arg Ala Pro Ala His Ala Ala 1085 1090 1095 Arg Ala Lys Glu Ala Ala Ala Ser Leu Pro Lys His Gln Gln Val 1100 1105 1110 Glu Ser Pro Thr Gly Ala Gly Ala Gly Gly Asp His Arg Ser Gln 1115 1120 1125 Arg Gly His Ala Ala Ser Pro Ala Arg Pro Ser Arg Pro Gly Gly 1130 1135 1140 Pro Gln Ser Arg Ala Arg Val Pro Ser Arg Ala Ala Pro Gly Lys 1145 1150 1155 Ser Glu Pro Pro Ser Lys Arg Pro Leu Ser Ser Lys Ser Gln Gln 1160 1165 1170 Ser Val Ser Ala Glu Asp Asp Glu Glu Glu Asp Ala Gly Phe Phe 1175 1180 1185 Lys Gly Gly Lys Glu Asp Leu Leu Ser Ser Ser Val Pro Lys Trp 1190 1195 1200 Pro Ser Ser Ser Thr Pro Arg Gly Gly Lys Asp Ala Asp Gly Ser 1205 1210 1215 Leu Ala Lys Glu Glu Arg Glu Pro Ala Ile Ala Leu Ala Pro Arg 1220 1225 1230 Gly Gly Ser Leu Ala Pro Val Lys Arg Pro Leu Pro Pro Pro Pro 1235 1240 1245 Gly Ser Ser Pro Arg Ala Ser His Val Pro Ser Arg Leu Pro Pro 1250 1255 1260 Arg Ser Ala Ala Thr Val Ser Pro Val Ala Gly Thr His Pro Trp 1265 1270 1275 Pro Gln Tyr Thr Thr Arg Ala Pro Pro Gly His Phe Ser Thr Thr 1280 1285 1290 Pro Met Leu Ser Leu Arg Gln Arg Met Met His Ala Arg Phe Arg 1295 1300 1305 Asn Pro Leu Ser Arg Gln Pro Ala Arg Pro Ser Tyr Arg Gln Gly 1310 1315 1320 Tyr Asn Gly Arg Pro Asn Val Glu Gly Lys Val Leu Pro Gly Ser 1325 1330 1335 Asn Gly Lys Pro Asn Gly Gln Arg Ile Ile Asn Gly Pro Gln Gly 1340 1345 1350 Thr Lys Trp Val Val Asp Leu Asp Arg Gly Leu Val Leu Asn Ala 1355 1360 1365 Glu Gly Arg Tyr Leu Gln Asp Ser His Gly Asn Pro Leu Arg Ile 1370 1375 1380 Lys Leu Gly Gly Asp Gly Arg Thr Ile Val Asp Leu Glu Gly Thr 1385 1390 1395 Pro Val Val Ser Pro Asp Gly Leu Pro Leu Phe Gly Gln Gly Arg 1400 1405 1410 His Gly Thr Pro Leu Ala Asn Ala Gln Asp Lys Pro Ile Leu Ser 1415 1420 1425 Leu Gly Gly Lys Pro Leu Val Gly Leu Glu Val Ile Lys Lys Thr 1430 1435 1440 Thr His Pro Pro Thr Thr Thr Met Gln Pro Thr Thr Thr Thr Thr 1445 1450 1455 Pro Leu Pro Thr Thr Thr Thr Pro Arg Pro Thr Thr Ala Thr Thr 1460 1465 1470 Arg Arg Thr Thr Thr Thr Arg Arg Thr Thr Thr Arg Arg Pro Thr 1475 1480 1485 Thr Thr Val Arg Thr Thr Thr Arg Thr Thr Thr Thr Thr Thr Pro 1490 1495 1500 Thr Pro Thr Thr Pro Ile Pro Thr Cys Pro Pro Gly Thr Leu Glu 1505 1510 1515 Arg His Asp Asp Asp Gly Asn Leu Ile Met Ser Ser Asn Gly Ile 1520 1525 1530 Pro Glu Cys Tyr Ala Glu Glu Asp Glu Phe Ser Gly Leu Glu Thr 1535 1540 1545 Asp Thr Ala Val Pro Thr Glu Glu Ala Tyr Val Ile Tyr Asp Glu 1550 1555 1560 Asp Tyr Glu Phe Glu Thr Ser Arg Pro Pro Thr Thr Thr Glu Pro 1565 1570 1575 Ser Thr Thr Ala Thr Thr Pro Arg Val Ile Pro Glu Glu Gly Ala 1580 1585 1590 Ile Ser Ser Phe Pro Glu Glu Glu Phe Asp Leu Ala Gly Arg Lys 1595 1600 1605 Arg Phe Val Ala Pro Tyr Val Thr Tyr Leu Asn Lys Asp Pro Ser 1610 1615 1620 Ala Pro Cys Ser Leu Thr Asp Ala Leu Asp His Phe Gln Val Asp 1625 1630 1635 Ser Leu Asp Glu Ile Ile Pro Asn Asp Leu Lys Lys Ser Asp Leu 1640 1645 1650 Pro Pro Gln His Ala Pro Arg Asn Ile Thr Val Val Ala Val Glu 1655 1660 1665 Gly Cys His Ser Phe Val Ile Val Asp Trp Asp Lys Ala Thr Pro 1670 1675 1680 Gly Asp Val Val Thr Gly Tyr Leu Val Tyr Ser Ala Ser Tyr Glu 1685 1690 1695 Asp Phe Ile Arg Asn Lys Trp Ser Thr Gln Ala Ser Ser Val Thr 1700 1705 1710 His Leu Pro Ile Glu Asn Leu Lys Pro Asn Thr Arg Tyr Tyr Phe 1715 1720 1725 Lys Val Gln Ala Gln Asn Pro His Gly Tyr Gly Pro Ile Ser Pro 1730 1735 1740 Ser Val Ser Phe Val Thr Glu Ser Asp Asn Pro Leu Leu Val Val 1745 1750 1755 Arg Pro Pro Gly Gly Glu Pro Ile Trp Ile Pro Phe Ala Phe Lys 1760 1765 1770 His Asp Pro Ser Tyr Thr Asp Cys His Gly Arg Gln Tyr Val Lys 1775 1780 1785 Arg Thr Trp Tyr Arg Lys Phe Val Gly Val Val Leu Cys Asn Ser 1790 1795 1800 Leu Arg Tyr Lys Ile Tyr Leu Ser Asp Asn Leu Lys Asp Thr Phe 1805 1810 1815 Tyr Ser Ile Gly Asp Ser Trp Gly Arg Gly Glu Asp His Cys Gln 1820 1825 1830 Phe Val Asp Ser His Leu Asp Gly Arg Thr Gly Pro Gln Ser Tyr 1835 1840 1845 Val Glu Ala Leu Pro Thr Ile Gln Gly Tyr Tyr Arg Gln Tyr Arg 1850 1855 1860 Gln Glu Pro Val Arg Phe Gly Asn Ile Gly Phe Gly Thr Pro Tyr 1865 1870 1875 Tyr Tyr Val Gly Trp Tyr Glu Cys Gly Val Ser Ile Pro Gly Lys 1880 1885 1890 Trp <210> 39 <211> 198 <212> PRT <213> Homo sapiens <400> 39 Met Ala Ala Asp Ile Ser Glu Ser Ser Gly Ala Asp Cys Lys Gly Asp 4>1 5 10 15 Pro Arg Asn Ser Ala Lys Leu Asp Ala Asp Tyr Pro Leu Arg Val Leu 20 25 30 Tyr Cys Gly Val Cys Ser Leu Pro Thr Glu Tyr Cys Glu Tyr Met Pro 35 40 45 Asp Val Ala Lys Cys Arg Gln Trp Leu Glu Lys Asn Phe Pro Asn Glu 50 55 60 Phe Ala Lys Leu Thr Val Glu Asn Ser Pro Lys Gln Glu Ala Gly Ile 65 70 75 80 Ser Glu Gly Gln Gly Thr Ala Gly Glu Glu Glu Glu Lys Lys Lys Gln 85 90 95 Lys Arg Gly Gly Arg Gly Gln Ile Lys Gln Lys Lys Lys Thr Val Pro 100 105 110 Gln Lys Val Thr Ile Ala Lys Ile Pro Arg Ala Lys Lys Lys Tyr Val 115 120 125 Thr Arg Val Cys Gly Leu Ala Thr Phe Glu Ile Asp Leu Lys Glu Ala 130 135 140 Gln Arg Phe Phe Ala Gln Lys Phe Ser Cys Gly Ala Ser Val Thr Gly 145 150 155 160 Glu Asp Glu Ile Ile Ile Gln Gly Asp Phe Thr Asp Asp Ile Ile Asp 165 170 175 Val Ile Gln Glu Lys Trp Pro Glu Val Asp Asp Asp Ser Ile Glu Asp 180 185 190 Leu Gly Glu Val Lys Lys 195 <210> 40 <211> 267 <212> PRT <213> Homo sapiens <400> 40 Met Ala Arg Phe Leu Thr Leu Cys Thr Trp Leu Leu Leu Leu Gly Pro 1 5 10 15 Gly Leu Leu Ala Thr Val Arg Ala Glu Cys Ser Gln Asp Cys Ala Thr 20 25 30 Cys Ser Tyr Arg Leu Val Arg Pro Ala Asp Ile Asn Phe Leu Ala Cys 35 40 45 Val Met Glu Cys Glu Gly Lys Leu Pro Ser Leu Lys Ile Trp Glu Thr 50 55 60 Cys Lys Glu Leu Leu Gln Leu Ser Lys Pro Glu Leu Pro Gln Asp Gly 65 70 75 80 Thr Ser Thr Leu Arg Glu Asn Ser Lys Pro Glu Glu Ser His Leu Leu 85 90 95 Ala Lys Arg Tyr Gly Gly Phe Met Lys Arg Tyr Gly Gly Phe Met Lys 100 105 110 Lys Met Asp Glu Leu Tyr Pro Met Glu Pro Glu Glu Glu Ala Asn Gly 115 120 125 Ser Glu Ile Leu Ala Lys Arg Tyr Gly Gly Phe Met Lys Lys Asp Ala 130 135 140 Glu Glu Asp Asp Ser Leu Ala Asn Ser Ser Asp Leu Leu Lys Glu Leu 145 150 155 160 Leu Glu Thr Gly Asp Asn Arg Glu Arg Ser His His Gln Asp Gly Ser 165 170 175 Asp Asn Glu Glu Glu Val Ser Lys Arg Tyr Gly Gly Phe Met Arg Gly 180 185 190 Leu Lys Arg Ser Pro Gln Leu Glu Asp Glu Ala Lys Glu Leu Gln Lys 195 200 205 Arg Tyr Gly Gly Phe Met Arg Arg Val Gly Arg Pro Glu Trp Trp Met 210 215 220 Asp Tyr Gln Lys Arg Tyr Gly Gly Phe Leu Lys Arg Phe Ala Glu Ala 225 230 235 240 Leu Pro Ser Asp Glu Glu Gly Glu Ser Tyr Ser Lys Glu Val Pro Glu 245 250 255 Met Glu Lys Arg Tyr Gly Gly Phe Met Arg Phe 260 265 <210> 41 <211> 105 <212> PRT <213> Homo sapiens <400> 41 Met Ala Lys Ile Ser Ser Pro Thr Glu Thr Glu Arg Cys Ile Glu Ser 1 5 10 15 Leu Ile Ala Val Phe Gln Lys Tyr Ala Gly Lys Asp Gly Tyr Asn Tyr 20 25 30 Thr Leu Ser Lys Thr Glu Phe Leu Ser Phe Met Asn Thr Glu Leu Ala 35 40 45 Ala Phe Thr Lys Asn Gln Lys Asp Pro Gly Val Leu Asp Arg Met Met 50 55 60 Lys Lys Leu Asp Thr Asn Ser Asp Gly Gln Leu Asp Phe Ser Glu Phe 65 70 75 80 Leu Asn Leu Ile Gly Gly Leu Ala Met Ala Cys His Asp Ser Phe Leu 85 90 95 Lys Ala Val Pro Ser Gln Lys Arg Thr 100 105 <210> 42 <211> 159 <212> PRT <213> Homo sapiens <400> 42 Met Ala Lys Ser Lys Asn His Thr Thr His Asn Gln Ser Arg Lys Trp 1 5 10 15 His Arg Asn Gly Ile Lys Lys Pro Arg Ser Gln Arg Tyr Glu Ser Leu 20 25 30 Lys Gly Val Asp Pro Lys Phe Leu Arg Asn Met Arg Phe Ala Lys Lys 35 40 45 His Asn Lys Lys Gly Leu Lys Lys Met Gln Ala Asn Asn Ala Lys Ala 50 55 60 Met Ser Ala Arg Ala Glu Ala Ile Lys Ala Leu Val Lys Pro Lys Glu 65 70 75 80 Val Lys Pro Lys Ile Pro Lys Gly Val Ser Arg Lys Leu Asp Arg Leu 85 90 95 Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile 100 105 110 Ala Lys Gly Leu Arg Leu Cys Arg Pro Lys Ala Lys Ala Lys Ala Lys 115 120 125 Ala Lys Asp Gln Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro 130 135 140 Ala Gln Ala Pro Lys Arg Thr Gln Ala Pro Thr Lys Ala Ser Glu 145 150 155 <210> 43 <211> 136 <212> PRT <213> Homo sapiens <400> 43 Met Gly Lys Phe Met Lys Pro Gly Lys Val Val Leu Val Leu Ala Gly 1 5 10 15 Arg Tyr Ser Gly Arg Lys Ala Val Ile Val Lys Asn Ile Asp Asp Gly 20 25 30 Thr Ser Asp Arg Pro Tyr Ser His Ala Leu Val Ala Gly Ile Asp Arg 35 40 45 Tyr Pro Arg Lys Val Thr Ala Ala Met Gly Lys Lys Lys Ile Ala Lys 50 55 60 Arg Ser Lys Ile Lys Ser Phe Val Lys Val Tyr Asn Tyr Asn His Leu 65 70 75 80 Met Pro Thr Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val 85 90 95 Asn Lys Asp Val Phe Arg Asp Pro Ala Leu Lys Arg Lys Ala Arg Arg 100 105 110 Glu Ala Lys Val Lys Phe Glu Glu Arg Tyr Lys Thr Gly Lys Asn Lys 115 120 125 Trp Phe Phe Gln Lys Leu Arg Phe 130 135 <210> 44 <211> 257 <212> PRT <213> Homo sapiens <400> 44 Met Gly Arg Val Ile Arg Gly Gln Arg Lys Gly Ala Gly Ser Val Phe 1 5 10 15 Arg Ala His Val Lys His Arg Lys Gly Ala Ala Arg Leu Arg Ala Val 20 25 30 Asp Phe Ala Glu Arg His Gly Tyr Ile Lys Gly Ile Val Lys Asp Ile 35 40 45 Ile His Asp Pro Gly Arg Gly Ala Pro Leu Ala Lys Val Val Phe Arg 50 55 60 Asp Pro Tyr Arg Phe Lys Lys Arg Thr Glu Leu Phe Ile Ala Ala Glu 65 70 75 80 Gly Ile His Thr Gly Gln Phe Val Tyr Cys Gly Lys Lys Ala Gln Leu 85 90 95 Asn Ile Gly Asn Val Leu Pro Val Gly Thr Met Pro Glu Gly Thr Ile 100 105 110 Val Cys Cys Leu Glu Glu Lys Pro Gly Asp Arg Gly Lys Leu Ala Arg 115 120 125 Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys 130 135 140 Lys Thr Arg Val Lys Leu Pro Ser Gly Ser Lys Lys Val Ile Ser Ser 145 150 155 160 Ala Asn Arg Ala Val Val Gly Val Val Ala Gly Gly Gly Arg Ile Asp 165 170 175 Lys Pro Ile Leu Lys Ala Gly Arg Ala Tyr His Lys Tyr Lys Ala Lys 180 185 190 Arg Asn Cys Trp Pro Arg Val Arg Gly Val Ala Met Asn Pro Val Glu 195 200 205 His Pro Phe Gly Gly Gly Asn His Gln His Ile Gly Lys Pro Ser Thr 210 215 220 Ile Arg Arg Asp Ala Pro Ala Gly Arg Lys Val Gly Leu Ile Ala Ala 225 230 235 240 Arg Arg Thr Gly Arg Leu Arg Gly Thr Lys Thr Val Gln Glu Lys Glu 245 250 255 Asn <210> 45 <211> 221 <212> PRT <213> Homo sapiens <400> 45 Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu 1 5 10 15 Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg 20 25 30 Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp 35 40 45 Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp 50 55 60 Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu 65 70 75 80 Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro 85 90 95 Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly 100 105 110 Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser 115 120 125 Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr 130 135 140 Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr 145 150 155 160 Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val 165 170 175 Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro 180 185 190 Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser 195 200 205 Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser 210 215 220 <210> 46 <211> 424 <212> PRT <213> Homo sapiens <400> 46 Met Ala Ala Gly Pro Ile Ser Glu Arg Asn Gln Asp Ala Thr Val Tyr 1 5 10 15 Val Gly Gly Leu Asp Glu Lys Val Ser Glu Pro Leu Leu Trp Glu Leu 20 25 30 Phe Leu Gln Ala Gly Pro Val Val Asn Thr His Met Pro Lys Asp Arg 35 40 45 Val Thr Gly Gln His Gln Gly Tyr Gly Phe Val Glu Phe Leu Ser Glu 50 55 60 Glu Asp Ala Asp Tyr Ala Ile Lys Ile Met Asn Met Ile Lys Leu Tyr 65 70 75 80 Gly Lys Pro Ile Arg Val Asn Lys Ala Ser Ala His Asn Lys Asn Leu 85 90 95 Asp Val Gly Ala Asn Ile Phe Ile Gly Asn Leu Asp Pro Glu Ile Asp 100 105 110 Glu Lys Leu Leu Tyr Asp Thr Phe Ser Ala Phe Gly Val Ile Leu Gln 115 120 125 Thr Pro Lys Ile Met Arg Asp Pro Asp Thr Gly Asn Ser Lys Gly Tyr 130 135 140 Ala Phe Ile Asn Phe Ala Ser Phe Asp Ala Ser Asp Ala Ala Ile Glu 145 150 155 160 Ala Met Asn Gly Gln Tyr Leu Cys Asn Arg Pro Ile Thr Val Ser Tyr 165 170 175 Ala Phe Lys Lys Asp Ser Lys Gly Glu Arg His Gly Ser Ala Ala Glu 180 185 190 Arg Leu Leu Ala Ala Gln Asn Pro Leu Ser Gln Ala Asp Arg Pro His 195 200 205 Gln Leu Phe Ala Asp Ala Pro Pro Pro Pro Ser Ala Pro Asn Pro Val 210 215 220 Val Ser Ser Leu Gly Ser Gly Leu Pro Pro Pro Gly Met Pro Pro Pro 225 230 235 240 Gly Ser Phe Pro Pro Pro Val Pro Pro Pro Gly Ala Leu Pro Pro Gly 245 250 255 Ile Pro Pro Ala Met Pro Pro Pro Pro Met Pro Pro Gly Ala Ala Gly 260 265 270 His Gly Pro Pro Ser Ala Gly Thr Pro Gly Ala Gly His Pro Gly His 275 280 285 Gly His Ser His Pro His Pro Phe Pro Pro Gly Gly Met Pro His Pro 290 295 300 Gly Met Ser Gln Met Gln Leu Ala His His Gly Pro His Gly Leu Gly 305 310 315 320 His Pro His Ala Gly Pro Pro Gly Ser Gly Gly Gln Pro Pro Pro Arg 325 330 335 Pro Pro Pro Gly Met Pro His Pro Gly Pro Pro Pro Met Gly Met Pro 340 345 350 Pro Arg Gly Pro Pro Phe Gly Ser Pro Met Gly His Pro Gly Pro Met 355 360 365 Pro Pro His Gly Met Arg Gly Pro Pro Pro Leu Met Pro Pro His Gly 370 375 380 Tyr Thr Gly Pro Pro Arg Pro Pro Pro Tyr Gly Tyr Gln Arg Gly Pro 385 390 395 400 Leu Pro Pro Pro Arg Pro Thr Pro Arg Pro Pro Val Pro Pro Arg Gly 405 410 415 Pro Leu Arg Gly Pro Leu Pro Gln 420 <210> 47 <211> 590 <212> PRT <213> Homo sapiens <400> 47 Met His Leu Ala Arg Leu Val Gly Ser Cys Ser Leu Leu Leu Leu Leu 1 5 10 15 Gly Ala Leu Ser Gly Trp Ala Ala Ser Asp Asp Pro Ile Glu Lys Val 20 25 30 Ile Glu Gly Ile Asn Arg Gly Leu Ser Asn Ala Glu Arg Glu Val Gly 35 40 45 Lys Ala Leu Asp Gly Ile Asn Ser Gly Ile Thr His Ala Gly Arg Glu 50 55 60 Val Glu Lys Val Phe Asn Gly Leu Ser Asn Met Gly Ser His Thr Gly 65 70 75 80 Lys Glu Leu Asp Lys Gly Val Gln Gly Leu Asn His Gly Met Asp Lys 85 90 95 Val Ala His Glu Ile Asn His Gly Ile Gly Gln Ala Gly Lys Glu Ala 100 105 110 Glu Lys Leu Gly His Gly Val Asn Asn Ala Ala Gly Gln Val Gly Lys 115 120 125 Glu Ala Asp Lys Leu Ile His His Gly Val His His Gly Ala Asn Gln 130 135 140 Ala Gly Ser Glu Ala Gly Lys Phe Gly Gln Gly Val Asp Asn Ala Ala 145 150 155 160 Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val His His 165 170 175 Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val 180 185 190 His His Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln 195 200 205 Gly Ala His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe 210 215 220 Gly Gln Gly Ile His His Ala Ala Gly Gln Val Gly Lys Glu Ala Glu 225 230 235 240 Lys Phe Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Asn Glu 245 250 255 Ala Gly Arg Phe Gly Gln Gly Val His His Gly Leu Ser Glu Gly Trp 260 265 270 Lys Glu Thr Glu Lys Phe Gly Gln Gly Val His His Thr Ala Gly Gln 275 280 285 Val Gly Lys Glu Ala Glu Lys Phe Gly Gln Gly Ala His His Ala Ala 290 295 300 Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Ala His His 305 310 315 320 Ala Ala Gly Gln Ala Gly Asn Glu Ala Gly Arg Phe Gly Gln Gly Val 325 330 335 His His Gly Leu Ser Glu Gly Trp Lys Glu Thr Glu Lys Phe Gly Gln 340 345 350 Gly Val His His Ala Ala Ser Gln Phe Gly Lys Glu Thr Glu Lys Leu 355 360 365 Gly His Gly Val His His Gly Val Asn Glu Ala Trp Lys Glu Ala Glu 370 375 380 Lys Phe Gly Gln Gly Val His His Ala Ala Ser Gln Val Gly Lys Glu 385 390 395 400 Glu Asp Arg Val Val Gln Gly Leu His His Gly Val Ser Gln Ala Gly 405 410 415 Arg Glu Ala Gly Gln Phe Gly His Asp Ile His His Thr Ala Gly Gln 420 425 430 Ala Gly Lys Glu Gly Asp Ile Ala Val His Gly Val Gln Pro Gly Val 435 440 445 His Glu Ala Gly Lys Glu Ala Gly Gln Phe Gly Gln Gly Val His His 450 455 460 Thr Leu Glu Gln Ala Gly Lys Glu Ala Asp Lys Ala Val Gln Gly Phe 465 470 475 480 His Thr Gly Val His Gln Ala Gly Lys Glu Ala Glu Lys Leu Gly Gln 485 490 495 Gly Val Asn His Ala Ala Asp Gln Ala Gly Lys Glu Val Glu Lys Leu 500 505 510 Gly Gln Gly Ala His His Ala Ala Gly Gln Ala Gly Lys Glu Leu Gln 515 520 525 Asn Ala His Asn Gly Val Asn Gln Ala Ser Lys Glu Ala Asn Gln Leu 530 535 540 Leu Asn Gly Asn His Gln Ser Gly Ser Ser Ser His Gln Gly Gly Ala 545 550 555 560 Thr Thr Thr Pro Leu Ala Ser Gly Ala Ser Val Asn Thr Pro Phe Ile 565 570 575 Asn Leu Pro Ala Leu Trp Arg Ser Val Ala Asn Ile Met Pro 580 585 590 <210> 48 <211> 379 <212> PRT <213> Homo sapiens <400> 48 Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile 1 5 10 15 Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser 20 25 30 Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His 35 40 45 Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu 50 55 60 Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys 65 70 75 80 Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu 85 90 95 Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala 100 105 110 Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser 115 120 125 Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu 130 135 140 Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn 145 150 155 160 Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp 165 170 175 Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys 180 185 190 Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu 195 200 205 Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys 210 215 220 Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu 225 230 235 240 Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys 245 250 255 Asp Ser Ala Ser Glu Glu Glu Ala His Val Gly Ala Gly Lys Arg Lys 260 265 270 Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys 275 280 285 Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro 290 295 300 Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys 305 310 315 320 Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val 325 330 335 Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu 340 345 350 Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe 355 360 365 Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys 370 375 <210> 49 <211> 331 <212> PRT <213> Homo sapiens <400> 49 Met Gly Gly Glu Gln Glu Glu Glu Arg Phe Asp Gly Met Leu Leu Ala 1 5 10 15 Met Ala Gln Gln His Glu Gly Gly Val Gln Glu Leu Val Asn Thr Phe 20 25 30 Phe Ser Phe Leu Arg Arg Lys Thr Asp Phe Phe Ile Gly Gly Glu Glu 35 40 45 Gly Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln 50 55 60 Leu Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu 65 70 75 80 Arg Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys 85 90 95 Ser Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala 100 105 110 Glu Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His 115 120 125 Glu Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp 130 135 140 Thr Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys 145 150 155 160 Pro Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln 165 170 175 Thr Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg 180 185 190 Leu Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg 195 200 205 Val Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn 210 215 220 Glu Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val 225 230 235 240 Val Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg 245 250 255 Leu Val Ser Ser Asp Pro Glu Ile Asn Thr Lys Lys Ile Asn Pro Glu 260 265 270 Asn Ser Lys Leu Ser Asp Leu Asp Ser Glu Thr Arg Ser Met Val Glu 275 280 285 Lys Met Met Tyr Asp Gln Arg Gln Lys Ser Met Gly Leu Pro Thr Ser 290 295 300 Asp Glu Gln Lys Lys Gln Glu Ile Leu Lys Lys Phe Met Asp Gln His 305 310 315 320 Pro Glu Met Asp Phe Ser Lys Ala Lys Phe Asn 325 330 <210> 50 <211> 422 <212> PRT <213> Homo sapiens <400> 50 Met Pro Ala Gly Arg Arg Gly Pro Ala Ala Gln Ser Ala Arg Arg Pro 1 5 10 15 Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Ala Pro 20 25 30 Arg Ala Gly Ser Gly Ala His Thr Ala Val Ile Ser Pro Gln Asp Pro 35 40 45 Thr Leu Leu Ile Gly Ser Ser Leu Leu Ala Thr Cys Ser Val His Gly 50 55 60 Asp Pro Pro Gly Ala Thr Ala Glu Gly Leu Tyr Trp Thr Leu Asn Gly 65 70 75 80 Arg Arg Leu Pro Pro Glu Leu Ser Arg Val Leu Asn Ala Ser Thr Leu 85 90 95 Ala Leu Ala Leu Ala Asn Leu Asn Gly Ser Arg Gln Arg Ser Gly Asp 100 105 110 Asn Leu Val Cys His Ala Arg Asp Gly Ser Ile Leu Ala Gly Ser Cys 115 120 125 Leu Tyr Val Gly Leu Pro Pro Glu Lys Pro Val Asn Ile Ser Cys Trp 130 135 140 Ser Lys Asn Met Lys Asp Leu Thr Cys Arg Trp Thr Pro Gly Ala His 145 150 155 160 Gly Glu Thr Phe Leu His Thr Asn Tyr Ser Leu Lys Tyr Lys Leu Arg 165 170 175 Trp Tyr Gly Gln Asp Asn Thr Cys Glu Glu Tyr His Thr Val Gly Pro 180 185 190 His Ser Cys His Ile Pro Lys Asp Leu Ala Leu Phe Thr Pro Tyr Glu 195 200 205 Ile Trp Val Glu Ala Thr Asn Arg Leu Gly Ser Ala Arg Ser Asp Val 210 215 220 Leu Thr Leu Asp Ile Leu Asp Val Val Thr Thr Asp Pro Pro Pro Asp 225 230 235 240 Val His Val Ser Arg Val Gly Gly Leu Glu Asp Gln Leu Ser Val Arg 245 250 255 Trp Val Ser Pro Pro Ala Leu Lys Asp Phe Leu Phe Gln Ala Lys Tyr 260 265 270 Gln Ile Arg Tyr Arg Val Glu Asp Ser Val Asp Trp Lys Val Val Asp 275 280 285 Asp Val Ser Asn Gln Thr Ser Cys Arg Leu Ala Gly Leu Lys Pro Gly 290 295 300 Thr Val Tyr Phe Val Gln Val Arg Cys Asn Pro Phe Gly Ile Tyr Gly 305 310 315 320 Ser Lys Lys Ala Gly Ile Trp Ser Glu Trp Ser His Pro Thr Ala Ala 325 330 335 Ser Thr Pro Arg Ser Glu Arg Pro Gly Pro Gly Gly Gly Ala Cys Glu 340 345 350 Pro Arg Gly Gly Glu Pro Ser Ser Gly Pro Val Arg Arg Glu Leu Lys 355 360 365 Gln Phe Leu Gly Trp Leu Lys Lys His Ala Tyr Cys Ser Asn Leu Ser 370 375 380 Phe Arg Leu Tyr Asp Gln Trp Arg Ala Trp Met Gln Lys Ser His Lys 385 390 395 400 Thr Arg Asn Gln Asp Glu Gly Ile Leu Pro Ser Gly Arg Arg Gly Thr 405 410 415 Ala Arg Gly Pro Ala Arg 420 <210> 51 <211> 390 <212> PRT <213> Homo sapiens <400> 51 Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 1 5 10 15 Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 20 25 30 Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 35 40 45 Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 50 55 60 Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 65 70 75 80 Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 85 90 95 Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 100 105 110 Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 115 120 125 His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 130 135 140 Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 145 150 155 160 Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 165 170 175 Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 180 185 190 Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 195 200 205 Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 210 215 220 Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 225 230 235 240 Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 245 250 255 Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 260 265 270 Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 275 280 285 Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 290 295 300 Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 305 310 315 320 Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 325 330 335 Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 340 345 350 Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 355 360 365 Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 370 375 380 Arg Ser Cys Lys Cys Ser 385 390 <210> 52 <211> 527 <212> PRT <213> Homo sapiens <400> 52 Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 1 5 10 15 Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 20 25 30 Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 35 40 45 Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 50 55 60 Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 65 70 75 80 Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 85 90 95 Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 100 105 110 Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 115 120 125 Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 130 135 140 Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 145 150 155 160 Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 165 170 175 Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 180 185 190 Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 195 200 205 His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 210 215 220 Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 225 230 235 240 Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 245 250 255 Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 260 265 270 Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 275 280 285 Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 290 295 300 His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 305 310 315 320 Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 325 330 335 Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 340 345 350 Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 355 360 365 Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 370 375 380 Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 385 390 395 400 Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 405 410 415 Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 420 425 430 Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 435 440 445 Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 450 455 460 Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 465 470 475 480 Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 485 490 495 Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 500 505 510 Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 515 520 525 <210> 53 <211> 412 <212> PRT <213> Homo sapiens <400> 53 Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 1 5 10 15 Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 20 25 30 Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 35 40 45 Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 50 55 60 Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 65 70 75 80 Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 85 90 95 Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 100 105 110 Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 115 120 125 Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 130 135 140 Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 145 150 155 160 Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 165 170 175 Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 180 185 190 Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 195 200 205 Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 210 215 220 Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 225 230 235 240 Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 245 250 255 Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 260 265 270 His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 275 280 285 Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 290 295 300 Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 305 310 315 320 Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 325 330 335 Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 340 345 350 Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 355 360 365 Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 370 375 380 Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 385 390 395 400 Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 405 410 <210> 54 <211> 509 <212> PRT <213> Homo sapiens <400> 54 Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His 1 5 10 15 Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu 20 25 30 Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly 35 40 45 Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly 50 55 60 Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys 65 70 75 80 Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His 85 90 95 Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu 100 105 110 Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser 115 120 125 Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln 130 135 140 Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn 145 150 155 160 Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr 165 170 175 Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly 180 185 190 Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser 195 200 205 Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile 210 215 220 Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr 225 230 235 240 Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu 245 250 255 Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe 260 265 270 Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys 275 280 285 Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile 290 295 300 Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys 305 310 315 320 Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg 325 330 335 Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala 340 345 350 Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp 355 360 365 Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile 370 375 380 Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala 385 390 395 400 Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr 405 410 415 Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn 420 425 430 Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp 435 440 445 Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val 450 455 460 Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile 465 470 475 480 Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu 485 490 495 Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe 500 505 <210> 55 <211> 1005 <212> PRT <213> Homo sapiens <400> 55 Met Thr Thr Glu Val Gly Ser Val Ser Glu Val Lys Lys Asp Ser Ser 1 5 10 15 Gln Leu Gly Thr Asp Ala Thr Lys Glu Lys Pro Lys Glu Val Ala Glu 20 25 30 Asn Gln Gln Asn Gln Ser Ser Asp Pro Glu Glu Glu Lys Gly Ser Gln 35 40 45 Pro Pro Pro Ala Ala Glu Ser Gln Ser Ser Leu Arg Arg Gln Lys Arg 50 55 60 Glu Lys Glu Thr Ser Glu Ser Arg Gly Ile Ser Arg Phe Ile Pro Pro 65 70 75 80 Trp Leu Lys Lys Gln Lys Ser Tyr Thr Leu Val Val Ala Lys Asp Gly 85 90 95 Gly Asp Lys Lys Glu Pro Thr Gln Ala Val Val Glu Glu Gln Val Leu 100 105 110 Asp Lys Glu Glu Pro Leu Pro Glu Glu Gln Arg Gln Ala Lys Gly Asp 115 120 125 Ala Glu Glu Met Ala Gln Lys Lys Gln Glu Ile Lys Val Glu Val Lys 130 135 140 Glu Glu Light Pro Ser Val Ser Light Glu Glu Light Pro Ser Val Ser Light 145 150 155 160 Val Glu Met Gln Pro Thr Glu Leu Val Ser Lys Glu Arg Glu Glu Lys 165 170 175 Val Lys Glu Thr Gln Glu Asp Lys Leu Glu Gly Gly Ala Ala Lys Arg 180 185 190 Glu Thr Lys Glu Val Gln Thr Asn Glu Leu Lys Ala Glu Lys Ala Ser 195 200 205 Gln Lys Val Thr Lys Lys Thr Lys Thr Val Gln Cys Lys Val Thr Leu 210 215 220 Leu Asp Gly Thr Glu Tyr Ser Cys Asp Leu Glu Lys His Ala Lys Gly 225 230 235 240 Gln Val Leu Phe Asp Lys Val Cys Glu His Leu Asn Leu Leu Glu Lys 245 250 255 Asp Tyr Phe Gly Leu Leu Phe Gln Glu Ser Pro Glu Gln Lys Asn Trp 260 265 270 Leu Asp Pro Ala Lys Glu Ile Lys Arg Gln Leu Arg Asn Leu Pro Trp 275 280 285 Leu Phe Thr Phe Asn Val Lys Phe Tyr Pro Pro Asp Pro Ser Gln Leu 290 295 300 Thr Glu Asp Ile Thr Arg Tyr Phe Leu Cys Leu Gln Leu Arg Gln Asp 305 310 315 320 Ile Ala Ser Gly Arg Leu Pro Cys Ser Phe Val Thr His Ala Leu Leu 325 330 335 Gly Ser Tyr Thr Leu Gln Ala Glu Leu Gly Asp Tyr Asp Pro Glu Glu 340 345 350 His Gly Ser Ile Asp Leu Ser Glu Phe Gln Phe Ala Pro Thr Gln Thr 355 360 365 Lys Glu Leu Glu Glu Lys Val Ala Glu Leu His Lys Thr His Arg Gly 370 375 380 Leu Ser Pro Ala Gln Ala Asp Ser Gln Phe Leu Glu Asn Ala Lys Arg 385 390 395 400 Leu Ser Met Tyr Gly Val Asp Leu His His Ala Lys Asp Ser Glu Gly 405 410 415 Val Asp Ile Lys Leu Gly Val Cys Ala Asn Gly Leu Leu Ile Tyr Lys 420 425 430 Asp Arg Leu Arg Ile Asn Arg Phe Ala Trp Pro Lys Ile Leu Lys Ile 435 440 445 Ser Tyr Lys Arg Ser Asn Phe Tyr Ile Lys Val Arg Pro Ala Glu Leu 450 455 460 Glu Gln Phe Glu Ser Thr Ile Gly Phe Lys Leu Pro Asn His Arg Ala 465 470 475 480 Ala Lys Arg Leu Trp Lys Val Cys Val Glu His His Thr Phe Tyr Arg 485 490 495 Leu Val Ser Pro Glu Gln Pro Pro Lys Ala Lys Phe Leu Thr Leu Gly 500 505 510 Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln Ala Gln Thr Arg Gln Ala 515 520 525 Ser Thr Leu Ile Asp Arg Pro Ala Pro His Phe Glu Arg Thr Ser Ser 530 535 540 Lys Arg Val Ser Arg Ser Leu Asp Gly Ala Pro Ile Gly Val Met Asp 545 550 555 560 Gln Ser Leu Met Lys Asp Phe Pro Gly Ala Ala Gly Glu Ile Ser Ala 565 570 575 Tyr Gly Pro Gly Leu Val Ser Ile Ala Val Val Gln Asp Gly Asp Gly 580 585 590 Arg Arg Glu Val Arg Ser Pro Thr Lys Ala Pro His Leu Gln Leu Ile 595 600 605 Glu Gly Lys Lys Asn Ser Leu Arg Val Glu Gly Asp Asn Ile Tyr Val 610 615 620 Arg His Ser Asn Leu Met Leu Glu Glu Leu Asp Lys Ala Gln Glu Asp 625 630 635 640 Ile Leu Lys His Gln Ala Ser Ile Ser Glu Leu Lys Arg Asn Phe Met 645 650 655 Glu Ser Thr Pro Glu Pro Arg Pro Asn Glu Trp Glu Lys Arg Arg Ile 660 665 670 Thr Pro Leu Ser Leu Gln Thr Gln Gly Ser Ser His Glu Thr Leu Asn 675 680 685 Ile Val Glu Glu Lys Lys Arg Ala Glu Val Gly Lys Asp Glu Arg Val 690 695 700 Ile Thr Glu Glu Met Asn Gly Lys Glu Ile Ser Pro Gly Ser Gly Pro 705 710 715 720 Gly Glu Ile Arg Lys Val Glu Pro Val Thr Gln Lys Asp Ser Thr Ser 725 730 735 Leu Ser Ser Glu Ser Ser Ser Ser Ser Ser Glu Ser Glu Glu Glu Asp 740 745 750 Val Gly Glu Tyr Arg Pro His His Arg Val Thr Glu Gly Thr Ile Arg 755 760 765 Glu Glu Gln Glu Tyr Glu Glu Glu Val Glu Glu Glu Pro Arg Pro Ala 770 775 780 Ala Lys Val Val Glu Arg Glu Glu Ala Val Pro Glu Ala Ser Pro Val 785 790 795 800 Thr Gln Ala Gly Ala Ser Val Ile Thr Val Glu Thr Val Ile Gln Glu 805 810 815 Asn Val Gly Ala Gln Lys Ile Pro Gly Glu Lys Ser Val His Glu Gly 820 825 830 Ala Leu Lys Gln Asp Met Gly Glu Glu Ala Glu Glu Glu Pro Gln Lys 835 840 845 Val Asn Gly Glu Val Ser His Val Asp Ile Asp Val Leu Pro Gln Ile 850 855 860 Ile Cys Cys Ser Glu Pro Pro Val Val Lys Thr Glu Met Val Thr Ile 865 870 875 880 Ser Asp Ala Ser Gln Arg Thr Glu Ile Ser Thr Lys Glu Val Pro Ile 885 890 895 Val Gln Thr Glu Thr Lys Thr Ile Thr Tyr Glu Ser Pro Gln Ile Asp 900 905 910 Gly Gly Ala Gly Gly Asp Ser Gly Thr Leu Leu Thr Ala Gln Thr Ile 915 920 925 Thr Ser Glu Ser Val Ser Thr Thr Thr Thr Thr His Ile Thr Lys Thr 930 935 940 Val Lys Gly Gly Ile Ser Glu Thr Arg Ile Glu Lys Arg Ile Val Ile 945 950 955 960 Thr Gly Asp Gly Asp Ile Asp His Asp Gln Ala Leu Ala Gln Ala Ile 965 970 975 Arg Glu Ala Arg Glu Gln His Pro Asp Met Ser Val Thr Arg Val Val 980 985 990 Val His Lys Glu Thr Glu Leu Ala Glu Glu Gly Glu Asp 995 1000 1005 <210> 56 <211> 219 <212> PRT <213> Homo sapiens <400> 56 Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu 1 5 10 15 Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val 20 25 30 Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn 35 40 45 Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala 50 55 60 Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala 65 70 75 80 Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val 85 90 95 Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu 100 105 110 Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly 115 120 125 Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe 130 135 140 Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala 145 150 155 160 Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr 165 170 175 Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val 180 185 190 Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile 195 200 205 Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu 210 215 <210> 57 <211> 151 <212> PRT <213> Homo sapiens <400> 57 Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser 1 5 10 15 Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His 20 25 30 Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser 35 40 45 Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala 50 55 60 Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp 65 70 75 80 Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys 85 90 95 Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala 100 105 110 Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg 115 120 125 Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly 130 135 140 Gly Arg Arg Gly Arg Arg Leu 145 150 <210> 58 <211> 266 <212> PRT <213> Homo sapiens <400> 58 Met Pro Lys Gly Lys Lys Ala Lys Gly Lys Lys Val Ala Pro Ala Pro 1 5 10 15 Ala Val Val Lys Lys Gln Glu Ala Lys Lys Val Val Asn Pro Leu Phe 20 25 30 Glu Lys Arg Pro Lys Asn Phe Gly Ile Gly Gln Asp Ile Gln Pro Lys 35 40 45 Arg Asp Leu Thr Arg Phe Val Lys Trp Pro Arg Tyr Ile Arg Leu Gln 50 55 60 Arg Gln Arg Ala Ile Leu Tyr Lys Arg Leu Lys Val Pro Pro Ala Ile 65 70 75 80 Asn Gln Phe Thr Gln Ala Leu Asp Arg Gln Thr Ala Thr Gln Leu Leu 85 90 95 Lys Leu Ala His Lys Tyr Arg Pro Glu Thr Lys Gln Glu Lys Lys Gln 100 105 110 Arg Leu Leu Ala Arg Ala Glu Lys Lys Ala Ala Gly Lys Gly Asp Val 115 120 125 Pro Thr Lys Arg Pro Pro Val Leu Arg Ala Gly Val Asn Thr Val Thr 130 135 140 Thr Leu Val Glu Asn Lys Lys Ala Gln Leu Val Val Ile Ala His Asp 145 150 155 160 Val Asp Pro Ile Glu Leu Val Val Phe Leu Pro Ala Leu Cys Arg Lys 165 170 175 Met Gly Val Pro Tyr Cys Ile Ile Lys Gly Lys Ala Arg Leu Gly Arg 180 185 190 Leu Val His Arg Lys Thr Cys Thr Thr Val Ala Phe Thr Gln Val Asn 195 200 205 Ser Glu Asp Lys Gly Ala Leu Ala Lys Leu Val Glu Ala Ile Arg Thr 210 215 220 Asn Tyr Asn Asp Arg Tyr Asp Glu Ile Arg Arg His Trp Gly Gly Asn 225 230 235 240 Val Leu Gly Pro Lys Ser Val Ala Arg Ile Ala Lys Leu Glu Lys Ala 245 250 255 Lys Ala Lys Glu Leu Ala Thr Lys Leu Gly 260 265 <210> 59 <211> 742 <212> PRT <213> Homo sapiens <400> 59 Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 1 5 10 15 Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 20 25 30 Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 35 40 45 Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 50 55 60 Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 65 70 75 80 Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 85 90 95 Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 100 105 110 Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 115 120 125 Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 130 135 140 Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 145 150 155 160 Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 165 170 175 Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 180 185 190 Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 195 200 205 Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 210 215 220 Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 225 230 235 240 Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 245 250 255 Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 260 265 270 Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 275 280 285 Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 290 295 300 Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 305 310 315 320 Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 325 330 335 Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 340 345 350 Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 355 360 365 Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 370 375 380 Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 385 390 395 400 Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 405 410 415 Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 420 425 430 Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 435 440 445 Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 450 455 460 Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 465 470 475 480 Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 485 490 495 Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 500 505 510 Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 515 520 525 Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 530 535 540 Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 545 550 555 560 Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 565 570 575 Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 580 585 590 Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 595 600 605 Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 610 615 620 Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 625 630 635 640 His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 645 650 655 Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 660 665 670 Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 675 680 685 Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 690 695 700 Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 705 710 715 720 Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 725 730 735 Val Leu Ser Ser Ala Leu 740 <210> 60 <211> 1214 <212> PRT <213> Homo sapiens <400> 60 Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 1 5 10 15 Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 20 25 30 Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 35 40 45 Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 50 55 60 Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 65 70 75 80 Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 85 90 95 Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 100 105 110 Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 115 120 125 Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 130 135 140 Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 145 150 155 160 Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 165 170 175 Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 180 185 190 Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 195 200 205 Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 210 215 220 Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 225 230 235 240 Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 245 250 255 Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 260 265 270 Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 275 280 285 Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 290 295 300 Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 305 310 315 320 Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 325 330 335 Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 340 345 350 Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 355 360 365 Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 370 375 380 Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 385 390 395 400 Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 405 410 415 Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 420 425 430 Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 435 440 445 Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 450 455 460 Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 465 470 475 480 Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 485 490 495 Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 500 505 510 Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 515 520 525 Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 530 535 540 Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn 545 550 555 560 Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly 565 570 575 Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 580 585 590 Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 595 600 605 Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 610 615 620 Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 625 630 635 640 Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 645 650 655 Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 660 665 670 Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 675 680 685 Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 690 695 700 Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 705 710 715 720 Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 725 730 735 Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu 740 745 750 Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu 755 760 765 Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu 770 775 780 Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys 785 790 795 800 Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 805 810 815 Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu 820 825 830 Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys 835 840 845 Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 850 855 860 Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 865 870 875 880 Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 885 890 895 Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 900 905 910 Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 915 920 925 Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 930 935 940 Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 945 950 955 960 Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 965 970 975 Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser 980 985 990 Val Val Pro Ala Pro Ala Gly Ser Gly Ala Pro Pro Gly Ser Leu Gly 995 1000 1005 Pro Ser Glu Gln Ile Gly Gln Ala Gly Ser Thr Ala Gly Pro Gln 1010 1015 1020 Gln Gln Gln Pro Ala Gly Ala Pro Gln Pro Gly Ala Val Pro Pro 1025 1030 1035 Gly Val Pro Pro Pro Gly Pro His Gly Pro Ser Pro Phe Pro Asn 1040 1045 1050 Gln Gln Thr Pro Pro Ser Met Met Pro Gly Ala Val Pro Gly Ser 1055 1060 1065 Gly His Pro Gly Val Ala Gly Asn Ala Pro Leu Gly Leu Pro Phe 1070 1075 1080 Gly Met Pro Pro Pro Pro Pro Pro Ala Pro Ser Ile Ile Pro 1085 1090 1095 Phe Gly Ser Leu Ala Asp Ser Ile Ser Ile Asn Leu Pro Ala Pro 1100 1105 1110 Pro Asn Leu His Gly His His His His Leu Pro Phe Ala Pro Gly 1115 1120 1125 Thr Leu Pro Pro Pro Asn Leu Pro Val Ser Met Ala Asn Pro Leu 1130 1135 1140 His Pro Asn Leu Pro Ala Thr Thr Thr Met Pro Ser Ser Leu Pro 1145 1150 1155 Leu Gly Pro Gly Leu Gly Ser Ala Ala Ala Gln Ser Pro Ala Ile 1160 1165 1170 Val Ala Ala Val Gln Gly Asn Leu Leu Pro Ser Ala Ser Pro Leu 1175 1180 1185 Pro Asp Pro Gly Thr Pro Leu Pro Pro Asp Pro Thr Ala Pro Ser 1190 1195 1200 Pro Gly Thr Val Thr Pro Val Pro Pro Pro Gln 1205 1210 <210> 61 <211> 199 <212> PRT <213> Homo sapiens <400> 61 Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln 1 5 10 15 Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln 20 25 30 Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly 35 40 45 Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu 50 55 60 Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile 65 70 75 80 Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 85 90 95 Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln 100 105 110 Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr 115 120 125 Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe 130 135 140 Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg 145 150 155 160 Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu 165 170 175 Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 180 185 190 Gly Met Pro Arg Gln Ile Leu 195 <210> 62 <211> 539 <212> PRT <213> Homo sapiens <400> 62 Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala 1 5 10 15 Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln 20 25 30 Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile 35 40 45 Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly 50 55 60 Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln 65 70 75 80 Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys 85 90 95 Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile 100 105 110 Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile 115 120 125 His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly 130 135 140 Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser Asp Arg 145 150 155 160 Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val 165 170 175 Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met 180 185 190 Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile 195 200 205 Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val 210 215 220 Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile Thr Arg 225 230 235 240 Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro 245 250 255 Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met 260 265 270 Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys 275 280 285 Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile 290 295 300 Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met 305 310 315 320 Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu Phe Ile 325 330 335 Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr 340 345 350 Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn Leu Asn 355 360 365 Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro Gly Lys 370 375 380 Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu 385 390 395 400 Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val 405 410 415 Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu 420 425 430 Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser 435 440 445 Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr 450 455 460 Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu 465 470 475 480 Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn Val Arg 485 490 495 Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln Pro Leu 500 505 510 Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser 515 520 525 Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg 530 535 <210> 63 <211> 758 <212> PRT <213> Homo sapiens <400> 63 Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 1 5 10 15 Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 20 25 30 Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 35 40 45 Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 50 55 60 Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 65 70 75 80 Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 85 90 95 Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 100 105 110 Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 115 120 125 Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 130 135 140 Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 145 150 155 160 Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 165 170 175 Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 180 185 190 Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 195 200 205 Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 210 215 220 Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 225 230 235 240 Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr 245 250 255 Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu 260 265 270 Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val 275 280 285 Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu 290 295 300 Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro 305 310 315 320 Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys 325 330 335 Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg 340 345 350 Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val 355 360 365 Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys 370 375 380 Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly 385 390 395 400 Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala 405 410 415 Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe 420 425 430 Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln 435 440 445 Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr 450 455 460 Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val 465 470 475 480 Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe 485 490 495 Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys 500 505 510 Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr 515 520 525 Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr 530 535 540 Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp 545 550 555 560 Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp 565 570 575 Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg 580 585 590 Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala 595 600 605 Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp 610 615 620 Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala 625 630 635 640 Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu 645 650 655 Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro 660 665 670 Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg 675 680 685 Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys 690 695 700 Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp 705 710 715 720 Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu 725 730 735 Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg 740 745 750 Arg Ser Leu Pro Ala Ile 755 <210> 64 <211> 491 <212> PRT <213> Homo sapiens <400> 64 Met Pro Leu Pro Val Gln Val Phe Asn Leu Gln Gly Ala Val Glu Pro 1 5 10 15 Met Gln Ile Asp Val Asp Pro Gln Glu Asp Pro Gln Asn Ala Pro Asp 20 25 30 Val Asn Tyr Val Val Glu Asn Pro Ser Leu Asp Leu Glu Gln Tyr Ala 35 40 45 Ala Ser Tyr Ser Gly Leu Met Arg Ile Glu Arg Leu Gln Phe Ile Ala 50 55 60 Asp His Cys Pro Thr Leu Arg Val Glu Ala Leu Lys Met Ala Leu Ser 65 70 75 80 Phe Val Gln Arg Thr Phe Asn Val Asp Met Tyr Glu Glu Ile His Arg 85 90 95 Lys Leu Ser Glu Ala Thr Arg Ser Ser Leu Arg Glu Leu Gln Asn Ala 100 105 110 Pro Asp Ala Ile Pro Glu Ser Gly Val Glu Pro Pro Ala Leu Asp Thr 115 120 125 Ala Trp Val Glu Ala Thr Arg Lys Lys Ala Leu Leu Lys Leu Glu Lys 130 135 140 Leu Asp Thr Asp Leu Lys Asn Tyr Lys Gly Asn Ser Ile Lys Glu Ser 145 150 155 160 Ile Arg Arg Gly His Asp Asp Leu Gly Asp His Tyr Leu Asp Cys Gly 165 170 175 Asp Leu Ser Asn Ala Leu Lys Cys Tyr Ser Arg Ala Arg Asp Tyr Cys 180 185 190 Thr Ser Ala Lys His Val Ile Asn Met Cys Leu Asn Val Ile Lys Val 195 200 205 Ser Val Tyr Leu Gln Asn Trp Ser His Val Leu Ser Tyr Val Ser Lys 210 215 220 Ala Glu Ser Thr Pro Glu Ile Ala Glu Gln Arg Gly Glu Arg Asp Ser 225 230 235 240 Gln Thr Gln Ala Ile Leu Thr Lys Leu Lys Cys Ala Ala Gly Leu Ala 245 250 255 Glu Leu Ala Ala Arg Lys Tyr Lys Gln Ala Ala Lys Cys Leu Leu Leu 260 265 270 Ala Ser Phe Asp His Cys Asp Phe Pro Glu Leu Leu Ser Pro Ser Asn 275 280 285 Val Ala Ile Tyr Gly Gly Leu Cys Ala Leu Ala Thr Phe Asp Arg Gln 290 295 300 Glu Leu Gln Arg Asn Val Ile Ser Ser Ser Ser Phe Lys Leu Phe Leu 305 310 315 320 Glu Leu Glu Pro Gln Val Arg Asp Ile Ile Phe Lys Phe Tyr Glu Ser 325 330 335 Lys Tyr Ala Ser Cys Leu Lys Met Leu Asp Glu Met Lys Asp Asn Leu 340 345 350 Leu Leu Asp Met Tyr Leu Ala Pro His Val Arg Thr Leu Tyr Thr Gln 355 360 365 Ile Arg Asn Arg Ala Leu Ile Gln Tyr Phe Ser Pro Tyr Val Ser Ala 370 375 380 Asp Met His Arg Met Ala Ala Ala Phe Asn Thr Thr Val Ala Ala Leu 385 390 395 400 Glu Asp Glu Leu Thr Gln Leu Ile Leu Glu Gly Leu Ile Ser Ala Arg 405 410 415 Val Asp Ser His Ser Lys Ile Leu Tyr Ala Arg Asp Val Asp Gln Arg 420 425 430 Ser Thr Thr Phe Glu Lys Ser Leu Leu Met Gly Lys Glu Phe Gln Arg 435 440 445 Arg Ala Lys Ala Met Met Leu Arg Ala Ala Val Leu Arg Asn Gln Ile 450 455 460 His Val Lys Ser Pro Pro Arg Glu Gly Ser Gln Gly Glu Leu Thr Pro 465 470 475 480 Ala Asn Ser Gln Ser Arg Met Ser Thr Asn Met 485 490 <210> 65 <211> 1512 <212> PRT <213> Homo sapiens <400> 65 Met Pro Ser Ser Ser Asp Thr Ala Leu Gly Gly Gly Gly Gly Leu Ser 1 5 10 15 Trp Ala Glu Lys Lys Leu Glu Glu Arg Arg Lys Arg Arg Arg Phe Leu 20 25 30 Ser Pro Gln Gln Pro Pro Leu Leu Leu Pro Leu Leu Gln Pro Gln Leu 35 40 45 Leu Gln Pro Pro Pro Pro Pro Pro Pro Leu Leu Phe Leu Ala Ala Pro 50 55 60 Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser Ser Cys 65 70 75 80 Phe Ser Pro Gly Pro Pro Leu Glu Val Lys Arg Leu Ala Arg Gly Lys 85 90 95 Arg Arg Ala Gly Gly Arg Gln Lys Arg Arg Arg Gly Pro Arg Ala Gly 100 105 110 Gln Glu Ala Glu Lys Arg Arg Val Phe Ser Leu Pro Gln Pro Gln Gln 115 120 125 Asp Gly Gly Gly Gly Ala Ser Ser Gly Gly Gly Val Thr Pro Leu Val 130 135 140 Glu Tyr Glu Asp Val Ser Ser Gln Ser Glu Gln Gly Leu Leu Leu Gly 145 150 155 160 Gly Ala Ser Ala Ala Thr Ala Ala Thr Ala Ala Gly Gly Thr Gly Gly 165 170 175 Ser Gly Gly Ser Pro Ala Ser Ser Ser Gly Thr Gln Arg Arg Gly Glu 180 185 190 Gly Ser Glu Arg Arg Pro Arg Arg Asp Arg Arg Ser Ser Ser Gly Arg 195 200 205 Ser Lys Glu Arg His Arg Glu His Arg Arg Arg Asp Gly Gln Arg Gly 210 215 220 Gly Ser Glu Ala Ser Lys Ser Arg Ser Arg His Ser His Ser Gly Glu 225 230 235 240 Glu Arg Ala Glu Val Ala Lys Ser Gly Ser Ser Ser Ser Gly Gly Gly 245 250 255 Arg Arg Light Ser Ala Ser Ala Thr Ser Ser Ser Ser Ser Arg Light 260 265 270 Asp Arg Asp Ser Lys Ala His Arg Ser Arg Thr Lys Ser Ser Lys Glu 275 280 285 Pro Pro Ser Ala Tyr Lys Glu Pro Pro Lys Ala Tyr Arg Glu Asp Lys 290 295 300 Thr Glu Pro Lys Ala Tyr Arg Arg Arg Arg Ser Leu Ser Pro Leu Gly 305 310 315 320 Gly Arg Asp Asp Ser Pro Val Ser His Arg Ala Ser Gln Ser Leu Arg 325 330 335 Ser Arg Lys Ser Pro Ser Pro Ala Gly Gly Gly Ser Ser Pro Tyr Ser 340 345 350 Arg Arg Leu Pro Arg Ser Pro Ser Pro Tyr Ser Arg Arg Arg Ser Pro 355 360 365 Ser Tyr Ser Arg His Ser Ser Tyr Glu Arg Gly Gly Asp Val Ser Pro 370 375 380 Ser Pro Tyr Ser Ser Ser Ser Trp Arg Arg Ser Arg Ser Pro Tyr Ser 385 390 395 400 Pro Val Leu Arg Arg Ser Gly Lys Ser Arg Ser Arg Ser Pro Tyr Ser 405 410 415 Ser Arg His Ser Arg Ser Arg Ser Arg His Arg Leu Ser Arg Ser Arg 420 425 430 Ser Arg His Ser Ser Ile Ser Pro Ser Thr Leu Thr Leu Lys Ser Ser 435 440 445 Leu Ala Ala Glu Leu Asn Lys Asn Lys Lys Ala Arg Ala Ala Glu Ala 450 455 460 Ala Arg Ala Ala Glu Ala Ala Light Ala Ala Glu Ala Thr Light Ala Ala 465 470 475 480 Glu Ala Ala Ala Lys Ala Ala Lys Ala Ser Asn Thr Ser Thr Pro Thr 485 490 495 Lys Gly Asn Thr Glu Thr Ser Ala Ser Ala Ser Gln Thr Asn His Val 500 505 510 Lys Asp Val Lys Lys Ile Lys Ile Glu His Ala Pro Ser Pro Ser Ser 515 520 525 Gly Gly Thr Leu Lys Asn Asp Lys Ala Lys Thr Lys Pro Pro Leu Gln 530 535 540 Val Thr Lys Val Glu Asn Asn Leu Ile Val Asp Lys Ala Thr Lys Lys 545 550 555 560 Ala Val Ile Val Gly Lys Glu Ser Lys Ser Ala Ala Thr Lys Glu Glu 565 570 575 Ser Val Ser Leu Lys Glu Lys Thr Lys Pro Leu Thr Pro Ser Ile Gly 580 585 590 Ala Lys Glu Lys Glu Gln His Val Ala Leu Val Thr Ser Thr Leu Pro 595 600 605 Pro Leu Pro Leu Pro Pro Met Leu Pro Glu Asp Lys Glu Ala Asp Ser 610 615 620 Leu Arg Gly Asn Ile Ser Val Lys Ala Val Lys Lys Glu Val Glu Lys 625 630 635 640 Lys Leu Arg Cys Leu Leu Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro 645 650 655 Gly Gly Asp Asp Leu Ser Lys Ser Pro Glu Glu Lys Lys Thr Ala Thr 660 665 670 Gln Leu His Ser Lys Arg Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly 675 680 685 Glu Thr Lys Glu Lys Asp Ile Asp Trp Gly Lys Arg Cys Val Asp Lys 690 695 700 Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr 705 710 715 720 Lys Ala Arg Asp Lys Asp Thr Gly Glu Met Val Ala Leu Lys Lys Val 725 730 735 Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu 740 745 750 Ile Lys Ile Leu Arg Gln Leu Thr His Gln Ser Ile Ile Asn Met Lys 755 760 765 Glu Ile Val Thr Asp Lys Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys 770 775 780 Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met Asp His Asp Leu Met Gly 785 790 795 800 Leu Leu Glu Ser Gly Leu Val His Phe Asn Glu Asn His Ile Lys Ser 805 810 815 Phe Met Arg Gln Leu Met Glu Gly Leu Asp Tyr Cys His Lys Lys Asn 820 825 830 Phe Leu His Arg Asp Ile Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg 835 840 845 Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser 850 855 860 Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg 865 870 875 880 Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp 885 890 895 Val Trp Ser Cys Gly Cys Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro 900 905 910 Ile Phe Gln Ala Asn Gln Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg 915 920 925 Ile Cys Gly Ser Pro Cys Pro Ala Val Trp Pro Asp Val Ile Lys Leu 930 935 940 Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu 945 950 955 960 Arg Glu Glu Phe Val Phe Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp 965 970 975 Tyr Met Leu Ala Leu Asp Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala 980 985 990 Leu Gln Cys Glu Phe Leu Arg Asp Val Glu Pro Ser Lys Met Pro Pro 995 1000 1005 Pro Asp Leu Pro Leu Trp Gln Asp Cys His Glu Leu Trp Ser Lys 1010 1015 1020 Lys Arg Arg Arg Gln Lys Gln Met Gly Met Thr Asp Asp Val Ser 1025 1030 1035 Thr Ile Lys Ala Pro Arg Lys Asp Leu Ser Leu Gly Leu Asp Asp 1040 1045 1050 Ser Arg Thr Asn Thr Pro Gln Gly Val Leu Pro Ser Ser Gln Leu 1055 1060 1065 Lys Ser Gln Gly Ser Ser Asn Val Ala Pro Val Lys Thr Gly Pro 1070 1075 1080 Gly Gln His Leu Asn His Ser Glu Leu Ala Ile Leu Leu Asn Leu 1085 1090 1095 Leu Gln Ser Lys Thr Ser Val Asn Met Ala Asp Phe Val Gln Val 1100 1105 1110 Leu Asn Ile Lys Val Asn Ser Glu Thr Gln Gln Gln Leu Asn Lys 1115 1120 1125 Ile Asn Leu Pro Ala Gly Ile Leu Ala Thr Gly Glu Lys Gln Thr 1130 1135 1140 Asp Pro Ser Thr Pro Gln Gln Glu Ser Ser Lys Pro Leu Gly Gly 1145 1150 1155 Ile Gln Pro Ser Ser Gln Thr Ile Gln Pro Lys Val Glu Thr Asp 1160 1165 1170 Ala Ala Gln Ala Ala Val Gln Ser Ala Phe Ala Val Leu Leu Thr 1175 1180 1185 Gln Leu Ile Lys Ala Gln Gln Ser Lys Gln Lys Asp Val Leu Leu 1190 1195 1200 Glu Glu Arg Glu Asn Gly Ser Gly His Glu Ala Ser Leu Gln Leu 1205 1210 1215 Arg Pro Pro Pro Glu Pro Ser Thr Pro Val Ser Gly Gln Asp Asp 1220 1225 1230 Leu Ile Gln His Gln Asp Met Arg Ile Leu Glu Leu Thr Pro Glu 1235 1240 1245 Pro Asp Arg Pro Arg Ile Leu Pro Pro Asp Gln Arg Pro Pro Glu 1250 1255 1260 Pro Pro Glu Pro Pro Pro Val Thr Glu Glu Asp Leu Asp Tyr Arg 1265 1270 1275 Thr Glu Asn Gln His Val Pro Thr Thr Ser Ser Ser Leu Thr Asp 1280 1285 1290 Pro His Ala Gly Val Lys Ala Ala Leu Leu Gln Leu Leu Ala Gln 1295 1300 1305 His Gln Pro Gln Asp Asp Pro Lys Arg Glu Gly Gly Ile Asp Tyr 1310 1315 1320 Gln Ala Gly Asp Thr Tyr Val Ser Thr Ser Asp Tyr Lys Asp Asn 1325 1330 1335 Phe Gly Ser Ser Ser Phe Ser Ser Ala Pro Tyr Val Ser Asn Asp 1340 1345 1350 Gly Leu Gly Ser Ser Ser Ala Pro Pro Leu Glu Arg Arg Ser Phe 1355 1360 1365 Ile Gly Asn Ser Asp Ile Gln Ser Leu Asp Asn Tyr Ser Thr Ala 1370 1375 1380 Ser Ser His Ser Gly Gly Pro Pro Gln Pro Ser Ala Phe Ser Glu 1385 1390 1395 Ser Phe Pro Ser Ser Val Ala Gly Tyr Gly Asp Ile Tyr Leu Asn 1400 1405 1410 Ala Gly Pro Met Leu Phe Ser Gly Asp Lys Asp His Arg Phe Glu 1415 1420 1425 Tyr Ser His Gly Pro Ile Ala Val Leu Ala Asn Ser Ser Asp Pro 1430 1435 1440 Ser Thr Gly Pro Glu Ser Thr His Pro Leu Pro Ala Lys Met His 1445 1450 1455 Asn Tyr Asn Tyr Gly Gly Asn Leu Gln Glu Asn Pro Ser Gly Pro 1460 1465 1470 Ser Leu Met His Gly Gln Thr Trp Thr Ser Pro Ala Gln Gly Pro 1475 1480 1485 Gly Tyr Ser Gln Gly Tyr Arg Gly His Ile Ser Thr Ser Thr Gly 1490 1495 1500 Arg Gly Arg Gly Arg Gly Leu Pro Tyr 1505 1510 <210> 66 <211> 352 <212> PRT <213> Homo sapiens <400> 66 Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys 1 5 10 15 Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp 20 25 30 Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met 35 40 45 Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser 50 55 60 Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln 65 70 75 80 Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala 85 90 95 Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro 100 105 110 Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys 115 120 125 Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln 130 135 140 Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys 145 150 155 160 Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Lys Arg Gln Gly 165 170 175 Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu 180 185 190 Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp 195 200 205 Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu 210 215 220 Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu 225 230 235 240 Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln 245 250 255 Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln 260 265 270 Pro Asn Gly Gly Leu Ser His Thr Gly Thr Pro Lys Pro Ser Gly Val 275 280 285 Gln Met Asp Gln Pro Cys Cys Arg Ala Leu Tyr Asp Phe Glu Pro Glu 290 295 300 Asn Glu Gly Glu Leu Gly Phe Lys Glu Gly Asp Ile Ile Thr Leu Thr 305 310 315 320 Asn Gln Ile Asp Glu Asn Trp Tyr Glu Gly Met Leu His Gly His Ser 325 330 335 Gly Phe Phe Pro Ile Asn Tyr Val Glu Ile Leu Val Ala Leu Pro His 340 345 350 <210> 67 <211> 142 <212> PRT <213> Homo sapiens <400> 67 Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 1 5 10 15 Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 20 25 30 Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 35 40 45 Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 50 55 60 Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 65 70 75 80 Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 85 90 95 Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 100 105 110 His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 115 120 125 Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 130 135 140 <210> 68 <211> 318 <212> PRT <213> Homo sapiens <400> 68 Met Pro Lys Arg Gly Lys Lys Gly Ala Val Ala Glu Asp Gly Asp Glu 1 5 10 15 Leu Arg Thr Glu Pro Glu Ala Lys Lys Ser Lys Thr Ala Ala Lys Lys 20 25 30 Asn Asp Lys Glu Ala Ala Gly Glu Gly Pro Ala Leu Tyr Glu Asp Pro 35 40 45 Pro Asp Gln Lys Thr Ser Pro Ser Gly Lys Pro Ala Thr Leu Lys Ile 50 55 60 Cys Ser Trp Asn Val Asp Gly Leu Arg Ala Trp Ile Lys Lys Lys Gly 65 70 75 80 Leu Asp Trp Val Lys Glu Glu Ala Pro Asp Ile Leu Cys Leu Gln Glu 85 90 95 Thr Lys Cys Ser Glu Asn Lys Leu Pro Ala Glu Leu Gln Glu Leu Pro 100 105 110 Gly Leu Ser His Gln Tyr Trp Ser Ala Pro Ser Asp Lys Glu Gly Tyr 115 120 125 Ser Gly Val Gly Leu Leu Ser Arg Gln Cys Pro Leu Lys Val Ser Tyr 130 135 140 Gly Ile Gly Asp Glu Glu His Asp Gln Glu Gly Arg Val Ile Val Ala 145 150 155 160 Glu Phe Asp Ser Phe Val Leu Val Thr Ala Tyr Val Pro Asn Ala Gly 165 170 175 Arg Gly Leu Val Arg Leu Glu Tyr Arg Gln Arg Trp Asp Glu Ala Phe 180 185 190 Arg Lys Phe Leu Lys Gly Leu Ala Ser Arg Lys Pro Leu Val Leu Cys 195 200 205 Gly Asp Leu Asn Val Ala His Glu Glu Ile Asp Leu Arg Asn Pro Lys 210 215 220 Gly Asn Lys Lys Asn Ala Gly Phe Thr Pro Gln Glu Arg Gln Gly Phe 225 230 235 240 Gly Glu Leu Leu Gln Ala Val Pro Leu Ala Asp Ser Phe Arg His Leu 245 250 255 Tyr Pro Asn Thr Pro Tyr Ala Tyr Thr Phe Trp Thr Tyr Met Met Asn 260 265 270 Ala Arg Ser Lys Asn Val Gly Trp Arg Leu Asp Tyr Phe Leu Leu Ser 275 280 285 His Ser Leu Leu Pro Ala Leu Cys Asp Ser Lys Ile Arg Ser Lys Ala 290 295 300 Leu Gly Ser Asp His Cys Pro Ile Thr Leu Tyr Leu Ala Leu 305 310 315 <210> 69 <211> 263 <212> PRT <213> Homo sapiens <400> 69 Met Ala Leu Ala Ser Val Leu Glu Arg Pro Leu Pro Val Asn Gln Arg 1 5 10 15 Gly Phe Phe Gly Leu Gly Gly Arg Ala Asp Leu Leu Asp Leu Gly Pro 20 25 30 Gly Ser Leu Ser Asp Gly Leu Ser Leu Ala Ala Pro Gly Trp Gly Val 35 40 45 Pro Glu Glu Pro Gly Ile Glu Met Leu His Gly Thr Thr Thr Leu Ala 50 55 60 Phe Lys Phe Arg His Gly Val Ile Val Ala Ala Asp Ser Arg Ala Thr 65 70 75 80 Ala Gly Ala Tyr Ile Ala Ser Gln Thr Val Lys Lys Val Ile Glu Ile 85 90 95 Asn Pro Tyr Leu Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys Ser 100 105 110 Phe Trp Glu Arg Leu Leu Ala Arg Gln Cys Arg Ile Tyr Glu Leu Arg 115 120 125 Asn Lys Glu Arg Ile Ser Val Ala Ala Ala Ser Lys Leu Leu Ala Asn 130 135 140 Met Val Tyr Gln Tyr Lys Gly Met Gly Leu Ser Met Gly Thr Met Ile 145 150 155 160 Cys Gly Trp Asp Lys Arg Gly Pro Gly Leu Tyr Tyr Val Asp Ser Glu 165 170 175 Gly Asn Arg Ile Ser Gly Ala Thr Phe Ser Val Gly Ser Gly Ser Val 180 185 190 Tyr Ala Tyr Gly Val Met Asp Arg Gly Tyr Ser Tyr Asp Leu Glu Val 195 200 205 Glu Gln Ala Tyr Asp Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr Tyr 210 215 220 Arg Asp Ala Tyr Ser Gly Gly Ala Val Asn Leu Tyr His Val Arg Glu 225 230 235 240 Asp Gly Trp Ile Arg Val Ser Ser Asp Asn Val Ala Asp Leu His Glu 245 250 255 Lys Tyr Ser Gly Ser Thr Pro 260 <210> 70 <211> 105 <212> PRT <213> Homo sapiens <400> 70 Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp 1 5 10 15 Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys 20 25 30 Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys 35 40 45 Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp 50 55 60 Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe 65 70 75 80 Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys 85 90 95 Leu Glu Ala Thr Ile Asn Glu Leu Val 100 105 <210> 71 <211> 894 <212> PRT <213> Homo sapiens <400> 71 Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 1 5 10 15 Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 20 25 30 Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 35 40 45 Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 50 55 60 Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 65 70 75 80 Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 85 90 95 Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 100 105 110 Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 115 120 125 Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 130 135 140 Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 145 150 155 160 Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 165 170 175 Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 180 185 190 His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 195 200 205 Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 210 215 220 Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 225 230 235 240 Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 245 250 255 His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln 260 265 270 Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 275 280 285 Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 290 295 300 Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 305 310 315 320 Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 325 330 335 Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 340 345 350 Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 355 360 365 Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 370 375 380 Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 385 390 395 400 Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 405 410 415 Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 420 425 430 Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 435 440 445 Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 450 455 460 Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 465 470 475 480 Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 485 490 495 Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 500 505 510 Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 515 520 525 Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 530 535 540 Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 545 550 555 560 Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 565 570 575 Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 580 585 590 Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 595 600 605 Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 610 615 620 His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 625 630 635 640 Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 645 650 655 Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 660 665 670 Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 675 680 685 Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 690 695 700 Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 705 710 715 720 Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 725 730 735 Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 740 745 750 Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 755 760 765 Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 770 775 780 Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 785 790 795 800 Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 805 810 815 Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 820 825 830 Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 835 840 845 Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 850 855 860 Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 865 870 875 880 Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 885 890 <210> 72 <211> 208 <212> PRT <213> Homo sapiens <400> 72 Met Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly 1 5 10 15 Lys Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro 20 25 30 Ala Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val 35 40 45 Arg Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn 50 55 60 Phe Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp 65 70 75 80 Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu 85 90 95 Val Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp 100 105 110 Tyr Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys 115 120 125 Leu Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys 130 135 140 Ile Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser 145 150 155 160 Leu Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala 165 170 175 Ser Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly 180 185 190 Lys Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys 195 200 205 <210> 73 <211> 290 <212> PRT <213> Homo sapiens <400> 73 Met Ala Pro Lys Arg Gln Ser Pro Leu Pro Pro Gln Lys Lys Lys Pro 1 5 10 15 Arg Pro Pro Pro Ala Leu Gly Pro Glu Glu Thr Ser Ala Ser Ala Gly 20 25 30 Leu Pro Lys Lys Gly Glu Lys Glu Gln Gln Glu Ala Ile Glu His Ile 35 40 45 Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln Ala Ser Glu 50 55 60 Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg Gln Pro Phe 65 70 75 80 Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn Phe Trp Val 85 90 95 Thr Thr Phe Val Asn His Pro Gln Val Ser Ala Leu Leu Gly Glu Glu 100 105 110 Asp Glu Glu Ala Leu His Tyr Leu Thr Arg Val Glu Val Thr Glu Phe 115 120 125 Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe Asp Glu Asn 130 135 140 Pro Tyr Phe Glu Asn Lys Val Leu Ser Lys Glu Phe His Leu Asn Glu 145 150 155 160 Ser Gly Asp Pro Ser Ser Lys Ser Thr Glu Ile Lys Trp Lys Ser Gly 165 170 175 Lys Asp Leu Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys Ala Ser Arg 180 185 190 Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp Phe Thr Asp 195 200 205 His Ser Asp Ala Gly Ala Asp Glu Leu Gly Glu Val Ile Lys Asp Asp 210 215 220 Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp Met Asp Asp 225 230 235 240 Glu Glu Gly Glu Gly Glu Glu Asp Asp Asp Asp Asp Glu Glu Glu Glu 245 250 255 Gly Leu Glu Asp Ile Asp Glu Glu Gly Asp Glu Asp Glu Gly Glu Glu 260 265 270 Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp Glu Gly Glu 275 280 285 Asp Asp 290 <210> 74 <211> 152 <212> PRT <213> Homo sapiens <400> 74 Met Ser Leu Val Ile Pro Glu Lys Phe Gln His Ile Leu Arg Val Leu 1 5 10 15 Asn Thr Asn Ile Asp Gly Arg Arg Lys Ile Ala Phe Ala Ile Thr Ala 20 25 30 Ile Lys Gly Val Gly Arg Arg Tyr Ala His Val Val Leu Arg Lys Ala 35 40 45 Asp Ile Asp Leu Thr Lys Arg Ala Gly Glu Leu Thr Glu Asp Glu Val 50 55 60 Glu Arg Val Ile Thr Ile Met Gln Asn Pro Arg Gln Tyr Lys Ile Pro 65 70 75 80 Asp Trp Phe Leu Asn Arg Gln Lys Asp Val Lys Asp Gly Lys Tyr Ser 85 90 95 Gln Val Leu Ala Asn Gly Leu Asp Asn Lys Leu Arg Glu Asp Leu Glu 100 105 110 Arg Leu Lys Lys Ile Arg Ala His Arg Gly Leu Arg His Phe Trp Gly 115 120 125 Leu Arg Val Arg Gly Gln His Thr Lys Thr Thr Gly Arg Arg Gly Arg 130 135 140 Thr Val Gly Val Ser Lys Lys Lys 145 150 <210> 75 <211> 166 <212> PRT <213> Homo sapiens <400> 75 Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 1 5 10 15 Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 20 25 30 Light Light Ala Val Leu Phe Cys Leu Ser Glu Asp Light Light Asn Ile Ile 35 40 45 Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 50 55 60 Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 65 70 75 80 Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 85 90 95 Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 100 105 110 Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Leu 115 120 125 Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 130 135 140 Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 145 150 155 160 Leu Glu Gly Lys Pro Leu 165 <210> 76 <211> 476 <212> PRT <213> Homo sapiens <400> 76 Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 1 5 10 15 Gly Ser Gly Glu Ala Gly Pro Leu Gln Ser Gly Glu Glu Ser Thr Gly 20 25 30 Thr Asn Ile Gly Glu Ala Leu Gly His Gly Leu Gly Asp Ala Leu Ser 35 40 45 Glu Gly Val Gly Lys Ala Ile Gly Lys Glu Ala Gly Gly Ala Ala Gly 50 55 60 Ser Lys Val Ser Glu Ala Leu Gly Gln Gly Thr Arg Glu Ala Val Gly 65 70 75 80 Thr Gly Val Arg Gln Val Pro Gly Phe Gly Val Ala Asp Ala Leu Gly 85 90 95 Asn Arg Val Gly Glu Ala Ala His Ala Leu Gly Asn Thr Gly His Glu 100 105 110 Ile Gly Arg Gln Ala Glu Asp Val Ile Arg His Gly Ala Asp Ala Val 115 120 125 Arg Gly Ser Trp Gln Gly Val Pro Gly His Asn Gly Ala Trp Glu Thr 130 135 140 Ser Gly Gly His Gly Ile Phe Gly Ser Gln Gly Gly Leu Gly Gly Gln 145 150 155 160 Gly Gln Gly Asn Pro Gly Gly Leu Gly Thr Pro Trp Val His Gly Tyr 165 170 175 Pro Gly Asn Ser Ala Gly Ser Phe Gly Met Asn Pro Gln Gly Ala Pro 180 185 190 Trp Gly Gln Gly Gly Asn Gly Gly Pro Pro Asn Phe Gly Thr Asn Thr 195 200 205 Gln Gly Ala Val Ala Gln Pro Gly Tyr Gly Ser Val Arg Ala Ser Asn 210 215 220 Gln Asn Glu Gly Cys Thr Asn Pro Pro Pro Ser Gly Ser Gly Gly Gly 225 230 235 240 Ser Ser Asn Ser Gly Gly Gly Ser Gly Ser Gln Ser Gly Ser Ser Gly 245 250 255 Ser Gly Ser Asn Gly Asp Asn Asn Asn Gly Ser Ser Ser Gly Gly Ser 260 265 270 Ser Ser Gly Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly 275 280 285 Ser Ser Gly Asn Ser Gly Gly Ser Arg Gly Asp Ser Gly Ser Glu Ser 290 295 300 Ser Trp Gly Ser Ser Thr Gly Ser Ser Ser Gly Asn His Gly Gly Ser 305 310 315 320 Gly Gly Gly Asn Gly His Lys Pro Gly Cys Glu Lys Pro Gly Asn Glu 325 330 335 Ala Arg Gly Ser Gly Glu Ser Gly Ile Gln Asn Ser Glu Thr Ser Pro 340 345 350 Gly Met Phe Asn Phe Asp Thr Phe Trp Lys Asn Phe Lys Ser Lys Leu 355 360 365 Gly Phe Ile Asn Trp Asp Ala Ile Asn Lys Asn Gln Val Pro Pro Pro 370 375 380 Ser Thr Arg Ala Leu Leu Tyr Phe Ser Arg Leu Trp Glu Asp Phe Lys 385 390 395 400 Gln Asn Thr Pro Phe Leu Asn Trp Lys Ala Ile Ile Glu Gly Ala Asp 405 410 415 Ala Ser Ser Leu Gln Lys Arg Ala Gly Arg Asp Asp Gln Asn Tyr Asn 420 425 430 Tyr Asn Gln His Ala Tyr Pro Thr Ala Tyr Gly Gly Lys Tyr Ser Val 435 440 445 Lys Thr Pro Ala Lys Gly Gly Val Ser Pro Ser Ser Ser Ala Ser Arg 450 455 460 Val Gln Pro Gly Leu Leu Gln Trp Val Lys Phe Trp 465 470 475 <210> 77 <211> 128 <212> PRT <213> Homo sapiens <400> 77 Met Ala Pro Val Lys Lys Leu Val Val Lys Gly Gly Lys Lys Lys Lys 1 5 10 15 Gln Val Leu Lys Phe Thr Leu Asp Cys Thr His Pro Val Glu Asp Gly 20 25 30 Ile Met Asp Ala Ala Asn Phe Glu Gln Phe Leu Gln Glu Arg Ile Lys 35 40 45 Val Asn Gly Lys Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu 50 55 60 Arg Ser Lys Ser Lys Ile Thr Val Thr Ser Glu Val Pro Phe Ser Lys 65 70 75 80 Arg Tyr Leu Lys Tyr Leu Thr Lys Lys Tyr Leu Lys Lys Asn Asn Leu 85 90 95 Arg Asp Trp Leu Arg Val Val Ala Asn Ser Lys Glu Ser Tyr Glu Leu 100 105 110 Arg Tyr Phe Gln Ile Asn Gln Asp Glu Glu Glu Glu Glu Asp Glu Asp 115 120 125 <210> 78 <211> 288 <212> PRT <213> Homo sapiens <400> 78 Met Ala Gly Glu Lys Val Glu Lys Pro Asp Thr Lys Glu Lys Lys Pro 1 5 10 15 Glu Ala Lys Lys Val Asp Ala Gly Gly Lys Val Lys Lys Gly Asn Leu 20 25 30 Lys Ala Lys Lys Pro Lys Lys Gly Lys Pro His Cys Ser Arg Asn Pro 35 40 45 Val Leu Val Arg Gly Ile Gly Arg Tyr Ser Arg Ser Ala Met Tyr Ser 50 55 60 Arg Lys Ala Met Tyr Lys Arg Lys Tyr Ser Ala Ala Lys Ser Lys Val 65 70 75 80 Glu Lys Lys Lys Lys Glu Lys Val Leu Ala Thr Val Thr Lys Pro Val 85 90 95 Gly Gly Asp Lys Asn Gly Gly Thr Arg Val Val Lys Leu Arg Lys Met 100 105 110 Pro Arg Tyr Tyr Pro Thr Glu Asp Val Pro Arg Lys Leu Leu Ser His 115 120 125 Gly Lys Lys Pro Phe Ser Gln His Val Arg Lys Leu Arg Ala Ser Ile 130 135 140 Thr Pro Gly Thr Ile Leu Ile Ile Leu Thr Gly Arg His Arg Gly Lys 145 150 155 160 Arg Val Val Phe Leu Lys Gln Leu Ala Ser Gly Leu Leu Leu Val Thr 165 170 175 Gly Pro Leu Val Leu Asn Arg Val Pro Leu Arg Arg Thr His Gln Lys 180 185 190 Phe Val Ile Ala Thr Ser Thr Lys Ile Asp Ile Ser Asn Val Lys Ile 195 200 205 Pro Lys His Leu Thr Asp Ala Tyr Phe Lys Lys Lys Lys Leu Arg Lys 210 215 220 Pro Arg His Gln Glu Gly Glu Ile Phe Asp Thr Glu Lys Glu Lys Tyr 225 230 235 240 Glu Ile Thr Glu Gln Arg Lys Ile Asp Gln Lys Ala Val Asp Ser Gln 245 250 255 Ile Leu Pro Lys Ile Lys Ala Ile Pro Gln Leu Gln Gly Tyr Leu Arg 260 265 270 Ser Val Phe Ala Leu Thr Asn Gly Ile Tyr Pro His Lys Leu Val Phe 275 280 285 <210> 79 <211> 582 <212> PRT <213> Homo sapiens <400> 79 Met Phe Pro Ala Gly Pro Pro Ser His Ser Leu Leu Arg Leu Pro Leu 1 5 10 15 Leu Gln Leu Leu Leu Leu Val Val Gln Ala Val Gly Arg Gly Leu Gly 20 25 30 Arg Ala Ser Pro Ala Gly Gly Pro Leu Glu Asp Val Val Ile Glu Arg 35 40 45 Tyr His Ile Pro Arg Ala Cys Pro Arg Glu Val Gln Met Gly Asp Phe 50 55 60 Val Arg Tyr His Tyr Asn Gly Thr Phe Glu Asp Gly Lys Lys Phe Asp 65 70 75 80 Ser Ser Tyr Asp Arg Asn Thr Leu Val Ala Ile Val Val Gly Val Gly 85 90 95 Arg Leu Ile Thr Gly Met Asp Arg Gly Leu Met Gly Met Cys Val Asn 100 105 110 Glu Arg Arg Arg Leu Ile Val Pro Pro His Leu Gly Tyr Gly Ser Ile 115 120 125 Gly Leu Ala Gly Leu Ile Pro Pro Asp Ala Thr Leu Tyr Phe Asp Val 130 135 140 Val Leu Leu Asp Val Trp Asn Lys Glu Asp Thr Val Gln Val Ser Thr 145 150 155 160 Leu Leu Arg Pro Pro His Cys Pro Arg Met Val Gln Asp Gly Asp Phe 165 170 175 Val Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr Ser Phe Asp 180 185 190 Thr Ser Tyr Ser Lys Gly Gly Thr Tyr Asp Thr Tyr Val Gly Ser Gly 195 200 205 Trp Leu Ile Lys Gly Met Asp Gln Gly Leu Leu Gly Met Cys Pro Gly 210 215 220 Glu Arg Arg Lys Ile Ile Ile Pro Pro Phe Leu Ala Tyr Gly Glu Lys 225 230 235 240 Gly Tyr Gly Thr Val Ile Pro Pro Gln Ala Ser Leu Val Phe His Val 245 250 255 Leu Leu Ile Asp Val His Asn Pro Lys Asp Ala Val Gln Leu Glu Thr 260 265 270 Leu Glu Leu Pro Pro Gly Cys Val Arg Arg Ala Gly Ala Gly Asp Phe 275 280 285 Met Arg Tyr His Tyr Asn Gly Ser Leu Met Asp Gly Thr Leu Phe Asp 290 295 300 Ser Ser Tyr Ser Arg Asn His Thr Tyr Asn Thr Tyr Ile Gly Gln Gly 305 310 315 320 Tyr Ile Ile Pro Gly Met Asp Gln Gly Leu Gln Gly Ala Cys Met Gly 325 330 335 Glu Arg Arg Arg Ile Thr Ile Pro Pro His Leu Ala Tyr Gly Glu Asn 340 345 350 Gly Thr Gly Asp Lys Ile Pro Gly Ser Ala Val Leu Ile Phe Asn Val 355 360 365 His Val Ile Asp Phe His Asn Pro Ala Asp Val Val Glu Ile Arg Thr 370 375 380 Leu Ser Arg Pro Ser Glu Thr Cys Asn Glu Thr Thr Lys Leu Gly Asp 385 390 395 400 Phe Val Arg Tyr His Tyr Asn Cys Ser Leu Leu Asp Gly Thr Gln Leu 405 410 415 Phe Thr Ser His Asp Tyr Gly Ala Pro Gln Glu Ala Thr Leu Gly Ala 420 425 430 Asn Lys Val Ile Glu Gly Leu Asp Thr Gly Leu Gln Gly Met Cys Val 435 440 445 Gly Glu Arg Arg Gln Leu Ile Val Pro Pro His Leu Ala His Gly Glu 450 455 460 Ser Gly Ala Arg Gly Val Pro Gly Ser Ala Val Leu Leu Phe Glu Val 465 470 475 480 Glu Leu Val Ser Arg Glu Asp Gly Leu Pro Thr Gly Tyr Leu Phe Val 485 490 495 Trp His Lys Asp Pro Pro Ala Asn Leu Phe Glu Asp Met Asp Leu Asn 500 505 510 Lys Asp Gly Glu Val Pro Pro Glu Glu Phe Ser Thr Phe Ile Lys Ala 515 520 525 Gln Val Ser Glu Gly Lys Gly Arg Leu Met Pro Gly Gln Asp Pro Glu 530 535 540 Lys Thr Ile Gly Asp Met Phe Gln Asn Gln Asp Arg Asn Gln Asp Gly 545 550 555 560 Lys Ile Thr Val Asp Glu Leu Lys Leu Lys Ser Asp Glu Asp Glu Glu 565 570 575 Arg Val His Glu Glu Leu 580 <210> 80 <211> 410 <212> PRT <213> Homo sapiens <400> 80 Met Val Leu Ser Gln Arg Gln Arg Asp Glu Leu Asn Arg Ala Ile Ala 1 5 10 15 Asp Tyr Leu Arg Ser Asn Gly Tyr Glu Glu Ala Tyr Ser Val Phe Lys 20 25 30 Lys Glu Ala Glu Leu Asp Val Asn Glu Glu Leu Asp Lys Lys Tyr Ala 35 40 45 Gly Leu Leu Glu Lys Lys Trp Thr Ser Val Ile Arg Leu Gln Lys Lys 50 55 60 Val Met Glu Leu Glu Ser Lys Leu Asn Glu Ala Lys Glu Glu Phe Thr 65 70 75 80 Ser Gly Gly Pro Leu Gly Gln Lys Arg Asp Pro Lys Glu Trp Ile Pro 85 90 95 Arg Pro Pro Glu Lys Tyr Ala Leu Ser Gly His Arg Ser Pro Val Thr 100 105 110 Arg Val Ile Phe His Pro Val Phe Ser Val Met Val Ser Ala Ser Glu 115 120 125 Asp Ala Thr Ile Lys Val Trp Asp Tyr Glu Thr Gly Asp Phe Glu Arg 130 135 140 Thr Leu Lys Gly His Thr Asp Ser Val Gln Asp Ile Ser Phe Asp His 145 150 155 160 Ser Gly Lys Leu Leu Ala Ser Cys Ser Ala Asp Met Thr Ile Lys Leu 165 170 175 Trp Asp Phe Gln Gly Phe Glu Cys Ile Arg Thr Met His Gly His Asp 180 185 190 His Asn Val Ser Ser Val Ala Ile Met Pro Asn Gly Asp His Ile Val 195 200 205 Ser Ala Ser Arg Asp Lys Thr Ile Lys Met Trp Glu Val Gln Thr Gly 210 215 220 Tyr Cys Val Lys Thr Phe Thr Gly His Arg Glu Trp Val Arg Met Val 225 230 235 240 Arg Pro Asn Gln Asp Gly Thr Leu Ile Ala Ser Cys Ser Asn Asp Gln 245 250 255 Thr Val Arg Val Trp Val Val Ala Thr Lys Glu Cys Lys Ala Glu Leu 260 265 270 Arg Glu His Glu His Val Val Glu Cys Ile Ser Trp Ala Pro Glu Ser 275 280 285 Ser Tyr Ser Ser Ile Ser Glu Ala Thr Gly Ser Glu Thr Lys Lys Ser 290 295 300 Gly Lys Pro Gly Pro Phe Leu Leu Ser Gly Ser Arg Asp Lys Thr Ile 305 310 315 320 Lys Met Trp Asp Val Ser Thr Gly Met Cys Leu Met Thr Leu Val Gly 325 330 335 His Asp Asn Trp Val Arg Gly Val Leu Phe His Ser Gly Gly Lys Phe 340 345 350 Ile Leu Ser Cys Ala Asp Asp Lys Thr Leu Arg Val Trp Asp Tyr Lys 355 360 365 Asn Lys Arg Cys Met Lys Thr Leu Asn Ala His Glu His Phe Val Thr 370 375 380 Ser Leu Asp Phe His Lys Thr Ala Pro Tyr Val Val Thr Gly Ser Val 385 390 395 400 Asp Gln Thr Val Lys Val Trp Glu Cys Arg 405 410 <210> 81 <211> 98 <212> PRT <213> Homo sapiens <400> 81 Met Ala Ala Glu Pro Leu Thr Glu Leu Glu Glu Ser Ile Glu Thr Val 1 5 10 15 Val Thr Thr Phe Phe Thr Phe Ala Arg Gln Glu Gly Arg Lys Asp Ser 20 25 30 Leu Ser Val Asn Glu Phe Lys Glu Leu Val Thr Gln Gln Leu Pro His 35 40 45 Leu Leu Lys Asp Val Gly Ser Leu Asp Glu Lys Met Lys Ser Leu Asp 50 55 60 Val Asn Gln Asp Ser Glu Leu Lys Phe Asn Glu Tyr Trp Arg Leu Ile 65 70 75 80 Gly Glu Leu Ala Lys Glu Ile Arg Lys Lys Lys Asp Leu Lys Ile Arg 85 90 95 Lys Lys <210> 82 <211> 246 <212> PRT <213> Homo sapiens <400> 82 Met Ser Arg Gly Ser Ser Ala Gly Phe Asp Arg His Ile Thr Ile Phe 1 5 10 15 Ser Pro Glu Gly Arg Leu Tyr Gln Val Glu Tyr Ala Phe Lys Ala Ile 20 25 30 Asn Gln Gly Gly Leu Thr Ser Val Ala Val Arg Gly Lys Asp Cys Ala 35 40 45 Val Ile Val Thr Gln Lys Lys Val Pro Asp Lys Leu Leu Asp Ser Ser 50 55 60 Thr Val Thr His Leu Phe Lys Ile Thr Glu Asn Ile Gly Cys Val Met 65 70 75 80 Thr Gly Met Thr Ala Asp Ser Arg Ser Gln Val Gln Arg Ala Arg Tyr 85 90 95 Glu Ala Ala Asn Trp Lys Tyr Lys Tyr Gly Tyr Glu Ile Pro Val Asp 100 105 110 Met Leu Cys Lys Arg Ile Ala Asp Ile Ser Gln Val Tyr Thr Gln Asn 115 120 125 Ala Glu Met Arg Pro Leu Gly Cys Cys Met Ile Leu Ile Gly Ile Asp 130 135 140 Glu Glu Gln Gly Pro Gln Val Tyr Lys Cys Asp Pro Ala Gly Tyr Tyr 145 150 155 160 Cys Gly Phe Lys Ala Thr Ala Ala Gly Val Lys Gln Thr Glu Ser Thr 165 170 175 Ser Phe Leu Glu Lys Lys Val Lys Lys Lys Phe Asp Trp Thr Phe Glu 180 185 190 Gln Thr Val Glu Thr Ala Ile Thr Cys Leu Ser Thr Val Leu Ser Ile 195 200 205 Asp Phe Lys Pro Ser Glu Ile Glu Val Gly Val Val Thr Val Glu Asn 210 215 220 Pro Lys Phe Arg Ile Leu Thr Glu Ala Glu Ile Asp Ala His Leu Val 225 230 235 240 Ala Leu Ala Glu Arg Asp 245 <210> 83 <211> 402 <212> PRT <213> Homo sapiens <400> 83 Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 1 5 10 15 Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 20 25 30 His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 35 40 45 Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 50 55 60 Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 65 70 75 80 Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 85 90 95 Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 100 105 110 Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 115 120 125 Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 130 135 140 Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 145 150 155 160 Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 165 170 175 Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 180 185 190 Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 195 200 205 Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 210 215 220 Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 225 230 235 240 Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 245 250 255 Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 260 265 270 Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 275 280 285 Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 290 295 300 Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 305 310 315 320 Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 325 330 335 Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 340 345 350 Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 355 360 365 Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 370 375 380 Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 385 390 395 400 Glu Pro <210> 84 <211> 709 <212> PRT <213> Homo sapiens <400> 84 Met Pro Ser Ala Thr Ser His Ser Gly Ser Gly Ser Lys Ser Ser Gly 1 5 10 15 Pro Pro Pro Pro Ser Gly Ser Ser Gly Ser Glu Ala Ala Ala Gly Ala 20 25 30 Gly Ala Ala Ala Pro Ala Ser Gln His Pro Ala Thr Gly Thr Gly Ala 35 40 45 Val Gln Thr Glu Ala Met Lys Gln Ile Leu Gly Val Ile Asp Lys Lys 50 55 60 Leu Arg Asn Leu Glu Lys Lys Lys Gly Lys Leu Asp Asp Tyr Gln Glu 65 70 75 80 Arg Met Asn Lys Gly Glu Arg Leu Asn Gln Asp Gln Leu Asp Ala Val 85 90 95 Ser Lys Tyr Gln Glu Val Thr Asn Asn Leu Glu Phe Ala Lys Glu Leu 100 105 110 Gln Arg Ser Phe Met Ala Leu Ser Gln Asp Ile Gln Lys Thr Ile Lys 115 120 125 Lys Thr Ala Arg Arg Glu Gln Leu Met Arg Glu Glu Ala Glu Gln Lys 130 135 140 Arg Leu Lys Thr Val Leu Glu Leu Gln Tyr Val Leu Asp Lys Leu Gly 145 150 155 160 Asp Asp Glu Val Arg Thr Asp Leu Lys Gln Gly Leu Asn Gly Val Pro 165 170 175 Ile Leu Ser Glu Glu Glu Leu Ser Leu Leu Asp Glu Phe Tyr Lys Leu 180 185 190 Val Asp Pro Glu Arg Asp Met Ser Leu Arg Leu Asn Glu Gln Tyr Glu 195 200 205 His Ala Ser Ile His Leu Trp Asp Leu Leu Glu Gly Lys Glu Lys Pro 210 215 220 Val Cys Gly Thr Thr Tyr Lys Val Leu Lys Glu Ile Val Glu Arg Val 225 230 235 240 Phe Gln Ser Asn Tyr Phe Asp Ser Thr His Asn His Gln Asn Gly Leu 245 250 255 Cys Glu Glu Glu Glu Ala Ala Ser Ala Pro Ala Val Glu Asp Gln Val 260 265 270 Pro Glu Ala Glu Pro Glu Pro Ala Glu Glu Tyr Thr Glu Gln Ser Glu 275 280 285 Val Glu Ser Thr Glu Tyr Val Asn Arg Gln Phe Met Ala Glu Thr Gln 290 295 300 Phe Thr Ser Gly Glu Lys Glu Gln Val Asp Glu Trp Thr Val Glu Thr 305 310 315 320 Val Glu Val Val Asn Ser Leu Gln Gln Gln Pro Gln Ala Ala Ser Pro 325 330 335 Ser Val Pro Glu Pro His Ser Leu Thr Pro Val Ala Gln Ala Asp Pro 340 345 350 Leu Val Arg Arg Gln Arg Val Gln Asp Leu Met Ala Gln Met Gln Gly 355 360 365 Pro Tyr Asn Phe Ile Gln Asp Ser Met Leu Asp Phe Glu Asn Gln Thr 370 375 380 Leu Asp Pro Ala Ile Val Ser Ala Gln Pro Met Asn Pro Thr Gln Asn 385 390 395 400 Met Asp Met Pro Gln Leu Val Cys Pro Pro Val His Ser Glu Ser Arg 405 410 415 Leu Ala Gln Pro Asn Gln Val Pro Val Gln Pro Glu Ala Thr Gln Val 420 425 430 Pro Leu Val Ser Ser Thr Ser Glu Gly Tyr Thr Ala Ser Gln Pro Leu 435 440 445 Tyr Gln Pro Ser His Ala Thr Glu Gln Arg Pro Gln Lys Glu Pro Ile 450 455 460 Asp Gln Ile Gln Ala Thr Ile Ser Leu Asn Thr Asp Gln Thr Thr Ala 465 470 475 480 Ser Ser Ser Leu Pro Ala Ala Ser Gln Pro Gln Val Phe Gln Ala Gly 485 490 495 Thr Ser Lys Pro Leu His Ser Ser Gly Ile Asn Val Asn Ala Ala Pro 500 505 510 Phe Gln Ser Met Gln Thr Val Phe Asn Met Asn Ala Pro Val Pro Pro 515 520 525 Val Asn Glu Pro Glu Thr Leu Lys Gln Gln Asn Gln Tyr Gln Ala Ser 530 535 540 Tyr Asn Gln Ser Phe Ser Ser Gln Pro His Gln Val Glu Gln Thr Glu 545 550 555 560 Leu Gln Gln Glu Gln Leu Gln Thr Val Val Gly Thr Tyr His Gly Ser 565 570 575 Pro Asp Gln Ser His Gln Val Thr Gly Asn His Gln Gln Pro Pro Gln 580 585 590 Gln Asn Thr Gly Phe Pro Arg Ser Asn Gln Pro Tyr Tyr Asn Ser Arg 595 600 605 Gly Val Ser Arg Gly Gly Ser Arg Gly Ala Arg Gly Leu Met Asn Gly 610 615 620 Tyr Arg Gly Pro Ala Asn Gly Phe Arg Gly Gly Tyr Asp Gly Tyr Arg 625 630 635 640 Pro Ser Phe Ser Asn Thr Pro Asn Ser Gly Tyr Thr Gln Ser Gln Phe 645 650 655 Ser Ala Pro Arg Asp Tyr Ser Gly Tyr Gln Arg Asp Gly Tyr Gln Gln 660 665 670 Asn Phe Lys Arg Gly Ser Gly Gln Ser Gly Pro Arg Gly Ala Pro Arg 675 680 685 Gly Arg Gly Gly Pro Pro Arg Pro Asn Arg Gly Met Pro Gln Met Asn 690 695 700 Thr Gln Gln Val Asn 705 <210> 85 <211> 437 <212> PRT <213> Homo sapiens <400> 85 Met Ser Val Ser Ala Arg Ser Ala Ala Ala Glu Glu Arg Ser Val Asn 1 5 10 15 Ser Ser Thr Met Val Ala Gln Gln Lys Asn Leu Glu Gly Tyr Val Gly 20 25 30 Phe Ala Asn Leu Pro Asn Gln Val Tyr Arg Lys Ser Val Lys Arg Gly 35 40 45 Phe Glu Phe Thr Leu Met Val Val Gly Glu Ser Gly Leu Gly Lys Ser 50 55 60 Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu Tyr Ser Pro Glu Tyr 65 70 75 80 Pro Gly Pro Ser His Arg Ile Lys Lys Thr Val Gln Val Glu Gln Ser 85 90 95 Lys Val Leu Ile Lys Glu Gly Gly Val Gln Leu Leu Leu Thr Ile Val 100 105 110 Asp Thr Pro Gly Phe Gly Asp Ala Val Asp Asn Ser Asn Cys Trp Gln 115 120 125 Pro Val Ile Asp Tyr Ile Asp Ser Lys Phe Glu Asp Tyr Leu Asn Ala 130 135 140 Glu Ser Arg Val Asn Arg Arg Gln Met Pro Asp Asn Arg Val Gln Cys 145 150 155 160 Cys Leu Tyr Phe Ile Ala Pro Ser Gly His Gly Leu Lys Pro Leu Asp 165 170 175 Ile Glu Phe Met Lys Arg Leu His Glu Lys Val Asn Ile Ile Pro Leu 180 185 190 Ile Ala Lys Ala Asp Thr Leu Thr Pro Glu Glu Cys Gln Gln Phe Lys 195 200 205 Lys Gln Ile Met Lys Glu Ile Gln Glu His Lys Ile Lys Ile Tyr Glu 210 215 220 Phe Pro Glu Thr Asp Asp Glu Glu Glu Asn Lys Leu Val Lys Lys Ile 225 230 235 240 Lys Asp Arg Leu Pro Leu Ala Val Val Gly Ser Asn Thr Ile Ile Glu 245 250 255 Val Asn Gly Lys Arg Val Arg Gly Arg Gln Tyr Pro Trp Gly Val Ala 260 265 270 Glu Val Glu Asn Gly Glu His Cys Asp Phe Thr Ile Leu Arg Asn Met 275 280 285 Leu Ile Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val 290 295 300 His Tyr Glu Asn Tyr Arg Ser Arg Lys Leu Ala Ala Val Thr Tyr Asn 305 310 315 320 Gly Val Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys Ser Pro Leu 325 330 335 Ala Gln Met Glu Glu Glu Arg Arg Glu His Val Ala Lys Met Lys Lys 340 345 350 Met Glu Met Glu Met Glu Gln Val Phe Glu Met Lys Val Lys Glu Lys 355 360 365 Val Gln Lys Leu Lys Asp Ser Glu Ala Glu Leu Gln Arg Arg His Glu 370 375 380 Gln Met Lys Lys Asn Leu Glu Ala Gln His Lys Glu Leu Glu Glu Lys 385 390 395 400 Arg Arg Gln Phe Glu Asp Glu Lys Ala Asn Trp Glu Ala Gln Gln Arg 405 410 415 Ile Leu Glu Gln Gln Asn Ser Ser Arg Thr Leu Glu Lys Asn Lys Lys 420 425 430 Lys Gly Lys Ile Phe 435 <210> 86 <211> 478 <212> PRT <213> Homo sapiens <400> 86 Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 1 5 10 15 Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 20 25 30 Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 35 40 45 Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 50 55 60 Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 65 70 75 80 Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 85 90 95 Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 100 105 110 Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 115 120 125 Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 130 135 140 Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 145 150 155 160 Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 165 170 175 Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 180 185 190 Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 195 200 205 Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 210 215 220 Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 225 230 235 240 Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 245 250 255 Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 260 265 270 Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 275 280 285 Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 290 295 300 Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 305 310 315 320 Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 325 330 335 Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 340 345 350 Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 355 360 365 Gln Arg Phe Ar...

Claims

1. Use of an agent for determining the quantitative or qualitative level of the biomarker DAG1 in a biological sample from a subject in the preparation of a reagent for diagnosing or prognosing a neurological disorder in the subject, wherein the neurological disorder is amyotrophic lateral sclerosis.

2. The use according to claim 1, wherein the biomarker is a gene.

3. The use according to claim 1, wherein the biomarker is a protein encoded by the gene DAG1.

4. The use according to claim 3, wherein the biomarker is a protein having UniProtKB / Swiss-Prot accession number Q14118.

5. The use according to any one of claims 1 to 4, wherein the diagnosis or prognosis comprises comparing the quantitative or qualitative levels of the biomarkers in the biological sample from the subject with the quantitative or qualitative levels of the corresponding biomarkers in a normal sample.

6. The use according to claim 5, wherein the quantitative or qualitative level of the biomarker in the biological sample from the subject is greater than the quantitative or qualitative level of the corresponding biomarker in a normal sample, indicating the quantitative or qualitative presence of the neurological disorder.

7. The use according to any one of claims 1-4 and 6, wherein the biological sample is selected from whole blood, serum, plasma, urine, interstitial fluid, peritoneal fluid, cervical swab, tears, saliva, buccal swab, skin, brain tissue and cerebrospinal fluid.

8. The use according to any one of claims 1-4 and 6, wherein the biological sample is whole blood.

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