A rat femoral artery blood sampling device

Abstract

The present invention discloses a blood sampling device for the femoral artery of rats, which comprises a first firmware and a second firmware. One end of the first firmware and the second firmware is hinged, and the other end is detachably connected through a locking member. The first firmware includes an elastic transparent airbag section, a locking plate and a hinged section. One end of the elastic transparent airbag section is fixedly connected to the locking plate, and the other end is fixedly connected to the arc-shaped hinged section. Among them, the elastic transparent airbag section is filled with physiological saline, and a switch plug is provided on the elastic transparent airbag section. The structure of the second firmware is the same as that of the first firmware. Among them, the elastic transparent airbag section on the second firmware is filled with gas, and a telescopic support frame is provided on the second firmware. A connecting plate is connected to the top of the telescopic support frame, and the connecting plate is connected to the blood sampler through an inclined groove. The needle body on the blood sampler faces the elastic transparent airbag section in the first firmware. A coating section is provided at the tip of the needle body of the blood sampler, and an expanding sponge film is coated on the surface of this coating section, which can not only complete blood sampling, but also compress and stop bleeding at the blood sampling site without ligating blood vessels.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a blood collection device for the femoral artery of rats. Background Art

[0002] Rodent rats are often used as animals for laboratory pharmacokinetic studies. During the experiment, blood from various parts of the rats is usually collected for research. Among them, femoral artery blood collection is one of the common blood collection methods. In the existing femoral artery blood collection, due to the destruction of the blood vessel wall structure during blood collection and the lack of good hemostasis measures, in order to avoid continuous bleeding from the wound caused by the blood collection needle, it is necessary to permanently ligate the blood vessel. However, the femoral artery is the main blood vessel supplying nutrients to the distal limb. After ligation, it will seriously affect the blood supply of the distal limb and further affect its motor and sensory functions. Therefore, it is very necessary to design a device that can not only collect blood but also directly stop bleeding after blood collection. Summary of the Invention

[0003] Aiming at the technical problem that the existing technology cannot stop bleeding at the blood collection site after blood collection and can only ligate the blood vessel for blood collection, which will affect the body function of rats, the present invention provides a blood collection device for the femoral artery of rats.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] A blood collection device for the femoral artery of rats includes a first fixing member and a second fixing member. One end of the first fixing member and the second fixing member is hinged, and the other end is detachably connected by a locking member. The first fixing member includes an elastic transparent airbag section, a locking plate, and a hinged section. The elastic transparent airbag section is an arc-shaped structure and is made of a mixture of silica gel and polypropylene materials. One end of the elastic transparent airbag section is fixedly connected to the locking plate, and the other end is fixedly connected to the arc-shaped hinged section. Among them, the elastic transparent airbag section is filled with physiological saline, and a switch plug is provided on the elastic transparent airbag section. The elastic transparent airbag section filled with physiological saline and the hinged section form a semi-circular structure. The structure of the second fixing member is the same as that of the first fixing member. Among them, the elastic transparent airbag section on the second fixing member is filled with gas, and this elastic transparent airbag section and the hinged section on the second fixing member form a semi-circular structure. A telescopic support frame is detachably connected to the hinged section on the second fixing member. The top of the support frame is connected to a connecting plate with a rotatable angle. An inclined groove is provided in this connecting plate. A blood collection device is detachably connected in the inclined groove, and the blood collection device can also move in the inclined groove. The needle body of this blood collection device faces the elastic transparent airbag section in the first fixing member. A coating section is provided at the tip of the needle body of the blood collection device, and an expanded sponge film is coated on the surface of this coating section.

[0006] Further, the two locking plates are arranged oppositely. The locking member includes a lock hole penetrating the locking plate and a lock pin inserted into the lock hole.

[0007] Further, the length of the articulated section on the first firmware is less than that on the second firmware, and the two articulated sections are articulated by a spindle.

[0008] Further, the telescopic support frame includes a horizontal telescopic rod and a vertical telescopic rod. One end of the horizontal telescopic rod is screwed to the articulated section on the second firmware, and the other end is fixedly connected to the vertical telescopic rod. The connection between the horizontal telescopic rod and the vertical telescopic rod is transitioned with a chamfered fillet.

[0009] Further, the top of the vertical telescopic rod is connected to the connecting plate by a spherical hinge. The inclined slot is an elliptical inclined slot, and the included angle between the central axis of this inclined slot and the surface of the connecting plate is 30° - 45°.

[0010] Further, the blood collector includes a syringe barrel and a piston core rod. One end of the syringe barrel is connected to the needle body, and the other end is provided with a piston core rod located inside the syringe barrel. The syringe barrel has a variable cross-section structure with a gradually increasing cross-sectional area from the connection end of the needle body to the installation end of the piston core rod, and the syringe barrel is clamped with the inclined slot.

[0011] In summary, the beneficial effects provided by the present invention are as follows: The femoral artery is placed in the fixed cavity formed by the first fixing member and the second fixing member, and the locking member locks the first fixing member and the second fixing member. At the same time, the blood vessel is clamped with a vascular clamp at the distal end to make the blood vessel in the blood collection part full. Since the elastic transparent airbag section is made of a mixture of silica gel and polypropylene materials, the elastic transparent airbag section of the first fixing member is filled with physiological saline. The telescopic support frame is stretched to an appropriate height, and the tip of the needle body of the blood collection device is aligned with the elastic transparent airbag section in the first fixing member. The needle body passes through the physiological saline and is quickly brought into the fixed cavity. After the expanding sponge film on the coating section contacts the physiological saline and the body fluid of the rat, it expands in the fixed cavity. The expanded expanding sponge film will not be stabbed into the blood vessel, and only the needle body is inserted into the blood vessel for blood collection. The elastic transparent airbag section filled with liquid is equivalent to a convex lens, which has the effect of magnifying the blood vessel, facilitating the observation of the blood vessel and making the blood collection more accurate. In addition, after blood collection, the needle is withdrawn, the switch plug is opened to release the physiological saline and gas in the cavity. The physiological saline with antibiotics can avoid infection. The expanded elastic transparent airbag section retracts, and the elastic transparent airbag section shrinks automatically due to tension, compressing the blood collection site of the blood vessel to achieve the purpose of compressing and stopping bleeding. Moreover, when the needle is withdrawn, the expanded expanding sponge film cannot pass through the elastic transparent airbag section and is left in the fixed cavity to compress the blood collection site, further strengthening the effect of compressing and stopping bleeding at the blood collection site. Finally, the vascular clamp at the distal end is loosened, the blood collection device is removed, and the wound is sutured to complete the blood collection. This blood collection device can not only complete blood collection but also compress and stop bleeding at the blood collection site without the need for blood vessel ligation. Therefore, it can avoid the problem of easily damaging nerves when bluntly separating blood vessels during ligation. Blood collection without ligation can also reduce the impact on the blood supply of the distal limb. In addition, the femoral artery can move. In the past, it was necessary to pull and fix it, and external pulling was prone to damage the blood vessel wall. Now, a fixed cavity is formed by the first fixing member and the second fixing member to fix the blood collection site of the blood vessel, avoiding damage to the blood vessel caused by external pulling. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 is a schematic structural diagram of a femoral artery blood collection device for rats provided by the present invention.

[0013] Figure 2 is a front view of the present invention without the blood collection device installed.

[0014] In the figure, 100 - the first fixing member, 110 - the locking plate, 120 - the elastic transparent airbag section, 130 - the hinge section, 200 - the second fixing member, 300 - the switch plug, 400 - the telescopic support frame, 410 - the horizontal telescopic rod, 420 - the vertical telescopic rod, 421 - the ball hinge, 500 - the connecting plate, 510 - the inclined groove, 600 - the blood collection device, 610 - the needle body, 611 - the expanding sponge film, 620 - the syringe barrel, 630 - the piston core rod, 700 - the locking member, 710 - the locking pin, 800 - the pin shaft. DETAILED DESCRIPTION OF THE INVENTION

[0015] In order to make the technical means, creative features, achieved purposes and functions of the present invention easy to understand, the present invention will be further described below with reference to specific illustrations.

[0016] As Figure 1 and Figure 2 shown, the present invention provides a blood collection device for the femoral artery of rats, which includes a first firmware 100 and a second firmware 200. One end of the first firmware 100 and the second firmware 200 is hinged, and the other end is detachably connected by a locking member 700. The first firmware 100 includes an elastic transparent airbag section 120, a locking plate 110 and a hinge section 130. The elastic transparent airbag section 120 is in an arc shape and is made of a mixture of silica gel and polypropylene materials. The elastic transparent airbag section 120 made of such materials will not cause leakage of liquid or gas after being punctured. One end of the elastic transparent airbag section 120 is fixedly connected to the locking plate 110, and the other end is fixedly connected to the arc-shaped hinge section 130. Among them, the elastic transparent airbag section 120 is filled with physiological saline, and a switch plug 300 is provided on the elastic transparent airbag section 120. The elastic transparent airbag section 120 filled with physiological saline and the hinge section 130 form a semi-circular structure. The structure of the second firmware 200 is the same as that of the first firmware 100. Among them, the elastic transparent airbag section 120 on the second firmware 200 is filled with gas, and this elastic transparent airbag section 120 and the hinge section 130 on the second firmware 200 form a semi-circular structure. The hinge section 130 on the second firmware 200 is detachably connected with a telescopic support frame 400, and the top of the support frame is connected with a connecting plate 500 that can rotate in angle. An inclined groove 510 is provided in the connecting plate 500, and a blood collection device 600 is detachably connected in the inclined groove 510. The needle body 610 of the blood collection device 600 faces the first firmware 100, and a coating section is provided at the tip of the needle body 610 of the blood collection device 600, and an expanded sponge film 611 is coated on the surface of this coating section.

[0017] After the rat inhales the anesthetic gas, the skin and connective tissue are incised in the inguinal region to fully expose the femoral artery, femoral vein and femoral nerve. After selecting the blood sampling position, using the above structure, the femoral artery is placed in the fixing cavity formed by the first fixture 100 and the second fixture 200, and the locking member 700 locks the first fixture 100 and the second fixture 200. At the same time, the blood vessel is clamped with a vascular clamp at the distal end to make the blood vessel in the blood sampling part full. Since the elastic transparent airbag section 120 is made of a mixture of silica gel and polypropylene materials, the elastic transparent airbag section 120 of the first fixture 100 is filled with physiological saline. The telescopic support frame 400 is stretched to an appropriate height, and the tip of the needle body 610 of the blood sampler 600 is aligned with the elastic transparent airbag section 120 in the first fixture 100. The needle body 610 passes through the physiological saline and is quickly brought into the fixing cavity. After the expansion sponge film 611 on the coating section contacts the physiological saline and the rat body fluid, it expands in the fixing cavity. After the expansion sponge film 611 expands, it cannot be brought into the blood vessel to affect blood sampling. Only the needle body 610 pierces into the blood vessel for blood sampling. The elastic transparent airbag section 120 filled with liquid is equivalent to a convex lens and has the effect of magnifying the blood vessel, which is convenient for observing the blood vessel and making blood sampling more accurate. In addition, after blood sampling, the needle is withdrawn, the switch plug 300 is opened to release the physiological saline and gas in the cavity. The physiological saline with antibiotics can avoid infection. The expanded elastic transparent airbag section 120 retracts, and the elastic transparent airbag section 120 automatically contracts due to the tension, compressing the blood vessel puncture site to achieve the purpose of compressing and stopping bleeding. Moreover, when the needle is withdrawn, the expanded expansion sponge film 611 cannot pass through the elastic transparent airbag section 120 and is left in the fixing cavity to compress the blood sampling site, further strengthening the effect of compressing and stopping bleeding at the blood sampling site. Finally, the vascular clamp at the distal end is loosened, this blood sampling device is removed, and the wound is sutured to complete blood sampling. This blood sampling device can not only complete blood sampling but also compress and stop bleeding at the blood sampling site without the need for blood vessel ligation. Therefore, the problem of blunt separation of blood vessels required during ligation, which is likely to damage nerves, can be avoided. Blood sampling without ligation can also reduce the impact on the blood supply of the distal limb. In addition, the femoral artery can move. In the past, it was necessary to perform traction and fixation, and external traction was also likely to damage the blood vessel wall. Now, the fixing cavity is formed by the first fixture 100 and the second fixture 200 to fix the blood vessel blood sampling site, avoiding damage to the blood vessel caused by external traction.

[0018] As one of the optional implementation manners, the two locking plates 110 are arranged oppositely. The locking member 700 includes a lock hole (not shown in the figure) penetrating through the locking plate 110 and a lock pin 710 inserted into the lock hole. Such a locking method is convenient for disassembly and assembly.

[0019] The length of the hinge section 130 on the first fixture 100 is less than the length of the hinge section 130 on the second fixture 200, which is convenient for installing the telescopic support frame 400 on the second fixture 200. The two hinge sections 130 are hinged by a shaft 800.

[0020] The telescopic support frame 400 includes a horizontal telescopic rod 410 and a vertical telescopic rod 420. One end of the horizontal telescopic rod 410 is screwed to the hinge section 130 on the second fixing member 200, and the other end is fixedly connected to the vertical telescopic rod 420. The connection between the horizontal telescopic rod 410 and the vertical telescopic rod 420 has a chamfered fillet transition. When the vertical telescopic rod 420 extends, it is convenient to select the blood collection angle of the blood collector 600. After contraction, it can avoid interfering with the opening of the first fixing member 100 and the second fixing member 200.

[0021] The top end of the vertical telescopic rod 420 is connected to the connecting plate 500 through a ball joint 421. The inclined slot 510 is an elliptical inclined slot 510, and the included angle between the central axis of this inclined slot 510 and the surface of the connecting plate 500 is 30° - 45°. The needle body 610 always enters the fixed cavity formed by the two fixing members obliquely, making it easier to insert the needle, and facilitating the blood collector 600 to maintain a convenient puncture blood collection posture. Such a passively maintained posture can be easier than manually maintaining the blood collection posture.

[0022] The blood collector 600 includes a syringe barrel 620 and a piston core rod 630. One end of the syringe barrel 620 is connected to the needle body 610, and the other end is provided with a piston core rod 630 located inside the syringe barrel 620. From the connection end of the needle body 610 to the installation end of the piston core rod 630, the syringe barrel 620 has a variable cross-section structure with a gradually increasing cross-sectional area, and the syringe barrel 620 is clamped with the inclined slot 510. When the needle body 610 approaches the first fixing member 100, it is equivalent to the section with the piston core rod 630 continuously approaching the first fixing member 100 until the syringe barrel 620 with an increasing cross-sectional area is clamped in the inclined slot 510. In this way, it will neither affect the needle insertion nor can it fix the blood collector 600, and it can also be smoothly withdrawn when retracting the needle.

[0023] The above is only the implementation mode of the present invention, and it does not limit the patent scope of the present invention accordingly. Any equivalent structure made by using the content of the specification and drawings of the present invention, directly or indirectly applied in other related technical fields, is equally within the patent protection scope of the present invention.

Claims

1. A rat femoral artery blood collection device, characterized in that: It includes a first firmware and a second firmware. One end of the first firmware and the second firmware is hinged, and the other end is detachably connected by a locking member. The first firmware includes an elastic transparent airbag section, a locking plate, and a hinge section. The elastic transparent airbag section is in an arc-shaped structure and is made of a mixture of silica gel and polypropylene materials. One end of the elastic transparent airbag section is fixedly connected to the locking plate, and the other end is fixedly connected to the arc-shaped hinge section. Wherein, the elastic transparent airbag section is filled with normal saline, and a switch plug is provided on the elastic transparent airbag section. And the elastic transparent airbag section filled with normal saline and the hinge section form a semi-circular structure. The two locking plates are arranged oppositely. The locking member includes a lock hole penetrating through the locking plate and a lock pin inserted into the lock hole. The length of the hinge section on the first firmware is less than the length of the hinge section on the second firmware. The two hinge sections are hinged by a spindle. The structure of the second firmware is the same as that of the first firmware. Wherein, the elastic transparent airbag section on the second firmware is filled with gas, and this elastic transparent airbag section and the hinge section on the second firmware form a semi-circular structure. A telescopic support frame is detachably connected to the hinge section on the second firmware. The top of the support frame is connected to a connecting plate with a rotatable angle. An inclined slot is provided in this connecting plate. A blood collector is detachably connected in the inclined slot and can also move in the inclined slot. The needle body on this blood collector faces the elastic transparent airbag section in the first firmware. A coating section is provided at the tip of the needle body of the blood collector, and an expanded sponge film is coated on the surface of this coating section.

2. The rat femoral artery blood sampling device according to claim 1, characterized in that: The telescopic support frame includes a horizontal telescopic rod and a vertical telescopic rod. One end of the horizontal telescopic rod is screwed to the hinge section on the second firmware, and the other end is fixedly connected to the vertical telescopic rod. And the connection between the horizontal telescopic rod and the vertical telescopic rod is in a fillet transition.

3. The rat femoral artery blood sampling device according to claim 2, characterized in that: The top of the vertical telescopic rod is connected to the connecting plate by a ball joint. The inclined slot is an elliptical inclined slot, and the included angle between the central axis of this inclined slot and the surface of the connecting plate is 30° - 45°.

4. The rat femoral artery blood collection device according to claim 1, wherein: The blood collector includes a syringe barrel and a piston core rod. One end of the syringe barrel is connected to the needle body, and the other end is provided with a piston core rod located inside the syringe barrel. The syringe barrel has a variable cross-section structure with a gradually increasing cross-sectional area from the needle body connection end to the piston core rod installation end, and the syringe barrel is clamped with the inclined slot.

Images