A herb extract for treating kidney stones, its preparation method and application

By using intermittent warm immersion percolation and macroporous resin adsorption enrichment technology, an extract rich in plantain ether glycoside, cimicifuga glycoside, and heterocimicifuga glycoside was extracted from *Hedychium coronarium* from Guizhou. This solved the problem of complex drug components in existing drugs and achieved a highly efficient and safe treatment effect for calculi.

CN113171382BActive Publication Date: 2025-12-02THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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Patent Information

Application Number
CN202110318359.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-03-25
Publication Date
2025-12-02
Estimated Expiration
2041-03-25

AI Technical Summary

Technical Problem

Existing drugs for treating kidney stones have complex ingredients, unclear mechanisms of action, and are difficult to control in terms of quality. There is a lack of highly effective, safe, and quality-controllable drug ingredients.

Method used

An extract rich in plantain glycoside, cimicifugoside, and heterocimicifugoside was extracted from *Gnaphalium affine* from Guizhou using intermittent warm immersion percolation water extraction combined with macroporous resin adsorption and enrichment technology. The effective components were separated and enriched by controlling temperature and solvent elution.

Benefits of technology

The obtained extract has a high content of active ingredients and has significant anti-inflammatory, analgesic and litholytic effects. It is also easy to operate, low in cost, and suitable for large-scale production.

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Abstract

This invention provides an extract of *Cimicifuga foetida*, made from *Cimicifuga foetida* produced in Guizhou Province, using an intermittent warm percolation method for water extraction. The extract contains 10%-25% cimicifugoside, 3%-15% iso-cimicifugoside, and 20%-50% plantago asiatica glycoside. The preparation method and applications are also disclosed. The *Cimicifuga foetida* extract provided by this invention has a high content of active ingredients and significant anti-inflammatory and litholytic pharmacological activities. It can be used as a raw material for the treatment and adjuvant treatment of cholecystitis, gallstones, hydronephrosis, kidney stones, nephritis, bladder stones, and uric acid stones. It can also be used as an intermediate raw material for the separation and purification of plantago asiatica glycoside, cimicifugoside, and iso-cimicifugoside chemical standards or reference standards. The preparation method provided by this invention effectively solves the problem of extraction and enrichment of active ingredients in *Cimicifuga foetida*, and has advantages such as low production cost, ease of large-scale production, and stable and controllable quality.
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