Tube luminometer

By using a reaction cup with filter membrane in a tube luminescent instrument and using a negative pressure pump for liquid removal, the problems of cross-contamination of the reaction cup and loss of the sampling tube in the prior art were solved, and more efficient and accurate tests were achieved process.

CN113376148BActive Publication Date: 2025-02-25ZEUS LIFE TECH (CHANGZHOU) CO LTD
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Patent Information

Application Number
CN202110690065.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-06-22
Publication Date
2025-02-25
Estimated Expiration
2041-06-22

AI Technical Summary

Technical Problem

During the test, existing tube luminescent instruments are prone to cross-contamination between reaction cups and serious loss of sampling tubes.

Method used

A reaction cup with filter membrane was designed to support the sample reaction liquid through the filter membrane at the bottom of the reaction cup, and remove the liquid with a negative pressure pump during the washing process, avoiding contamination caused by the use of steel needles or sampling tubes and loss.

Benefits of technology

It effectively avoids cross-contamination between reaction cups and loss of sampling tubes, improves the efficiency and accuracy of the test, and reduces the risk of pollution during the test.

✦ Generated by Eureka AI based on patent content.

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    Figure CN113376148B_ABST
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Abstract

The present invention relates to a tubular luminometer, comprising a frame, an operating table arranged on the frame, a reaction disk arranged on the operating table, each first cup placement hole being suitable for placing a reaction cup; a reaction cup, a liquid inlet being arranged at the upper end of the reaction cup, a liquid discharge port being arranged at the bottom of the reaction cup, and a filter membrane being arranged at the liquid discharge port; a washing mechanism, when the reaction disk moves the reaction cup to a washing station, the washing mechanism is suitable for forming a sealed connection with the liquid discharge port of the reaction cup to suck out the sample reaction liquid in the reaction cup from the liquid discharge port; and is suitable for adding a cleaning liquid to the liquid inlet of the reaction cup to clean the microspheres in the reaction cup. It avoids the use of a steel needle to remove liquid-carrying contamination, and also avoids the need to consume a large number of tip heads to remove liquid during the test.
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Description

Technical Field

[0001] The invention relates to the technical field of tubular luminescence, and in particular to a tubular luminescence instrument. Background Art

[0002] The existing tube-type luminometer has the problems of cross contamination between reaction cups during the test, serious loss of sampling tubes, and a small number of workstations on the reagent tray and reaction tray in the tube-type luminometer.

[0003] The principle of the tube luminescence test is: the sample and the microsphere reagent (the microspheres are magnetic microspheres) react in the reaction cup, so that the reaction substances in the sample adhere to the microspheres, and then the microspheres are cleaned, and finally another reagent is added for chemiluminescence testing. The more reaction substances adhere to the magnetic microspheres, the brighter the light emitted.

[0004] The existing tubular luminescence instrument mainly uses the "magnet + steel needle" method to wash the reaction cup, that is, use a magnet to absorb the reaction material (for example, suck it to the edge of the reaction cup), and then use a steel needle to remove the liquid, or a disposable tip to remove the liquid. The reaction cup used in the tubular luminescence instrument is a conventional cup body (open at the top and closed at the bottom). This kind of cup requires a steel needle when filling it with liquid and washing the cup. The steel needle must be cleaned once it is used up. However, in actual operations, the flushing of the steel needle is incomplete and the steel needle will still carry contamination. In order to completely avoid this contamination, a disposable tip must be used. A complex experiment will cause considerable loss to the tip.

[0005] Secondly, the reaction tray and reagent tray in the tube-type luminometer are linear and can only move in a linear direction, so that the reaction tray and reagent tray occupy a larger space when working in the instrument. In instruments of the same specifications and models, more workstations cannot be designed for the reaction tray and reagent tray, resulting in an overall small number of workstations in existing tube-type luminometers. Summary of the invention

[0006] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a tubular luminometer to solve the problem that when the existing tubular luminometer performs a tubular luminescence test, the washing of the reaction cups easily causes cross contamination between the reaction cups.

[0007] The technical solution adopted by the present invention to solve its technical problem is:

[0008] A tubular luminometer is provided, comprising:

[0009] A frame, an operating table is arranged on the frame, a reaction disc is arranged on the operating table, a circle of first cup placement holes is arranged on the reaction disc, each of the first cup placement holes is suitable for placing a reaction cup, and the reaction disc is arranged to rotate horizontally on the operating table, suitable for moving each reaction cup on the reaction disc to a washing station in sequence;

[0010] A reaction cup, wherein a liquid inlet is provided at the upper end of the reaction cup, a liquid discharge port is provided at the bottom of the reaction cup, and a filter membrane is arranged at the liquid discharge port; when the reaction cup is at normal pressure, the filter membrane is suitable for supporting the sample reaction liquid in the reaction cup;

[0011] The washing mechanism is arranged at the washing station of the operating table. When the reaction tray moves the reaction cup to the washing station, the washing mechanism is suitable for forming a sealed connection with the discharge port of the reaction cup to suck out the sample reaction liquid in the reaction cup from the discharge port; and is suitable for adding cleaning liquid to the liquid inlet of the reaction cup to clean the microspheres in the reaction cup.

[0012] Furthermore, a reagent tray is arranged on the operating table, and the reaction tray is in a circular shape. The reagent tray is horizontally rotatable and arranged in the circular hole of the reaction tray. A first reagent rack for placing Class A reagent bottles and tube seats for placing Class A sampling tubes are arranged on the reagent tray, and the number of the tube seats corresponds to the number of placement positions for Class A reagent bottles on the first reagent rack.

[0013] Furthermore, a plurality of support components are arranged on the operating table, and the upper end of the support component and the lower end surface of the reaction disk form a horizontal rolling support;

[0014] A gear ring is fixedly arranged at the lower end of the reaction disk, and a first driving motor is fixedly arranged on the operating table. The first driving motor is connected to a gear, and the gear is meshed with the gear ring. The first driving motor drives the gear ring through the gear to drive the reaction disk to rotate horizontally on each supporting assembly.

[0015] Furthermore, the support assembly includes an upper seat, a lower seat and a rolling ball. The lower end of the upper seat is threadedly connected with the upper end of the lower seat. A ball groove is provided at the upper end of the upper seat, and the rolling ball is arranged in the ball groove.

[0016] Furthermore, a cup seat is arranged at the bottom of the reaction cup, the filter membrane is clamped between the cup body of the reaction cup and the cup seat, and a liquid hole is arranged on the cup seat, which is suitable for discharging the liquid in the reaction cup.

[0017] Furthermore, the washing mechanism includes a liquid discharging mechanism and a liquid injection mechanism;

[0018] The liquid discharge mechanism comprises a negative pressure pump, a liquid discharge pipe, an upper baffle and a push-pull electromagnet;

[0019] The outlet at the lower end of the liquid discharge pipe is connected to the negative pressure pump, and the push-pull electromagnet is connected to the liquid discharge pipe, and is suitable for driving the liquid discharge pipe to move up and down, so that the inlet at the upper end of the liquid discharge pipe forms a plug-in fit with the liquid discharge port at the bottom of the reaction cup, and the upper baffle is fixedly arranged above the washing station, and is suitable for preventing the reaction cup at the washing station from moving upward;

[0020] The injection mechanism includes an injection bracket, an injection tube and a translation cylinder. The translation cylinder is connected to the injection bracket to drive the injection bracket to translate. The injection tube is arranged on the injection bracket and is suitable for injecting cleaning liquid into the reaction cup at the washing station.

[0021] Furthermore, a sample loading mechanism is provided on the frame;

[0022] The sample loading mechanism includes an operating mechanism, a sampling arm, a card plate, a tube rack for placing Class B sampling tubes, and a second reagent rack for placing Class B reagent bottles; wherein

[0023] The operating mechanism is suitable for driving the sampling arm to move in up and down, left and right, and front and back directions;

[0024] The sampling arm is suitable for inserting a type B sampling tube on the tube rack;

[0025] The card plate is fixed on the operating table, and a through hole and a card slot are provided on the upper end of the card plate. The card slot is connected to the through hole. The sampling arm is suitable for driving the Class B sampling tube to pass through the through hole, and the sampling arm can move laterally in the card slot to drive the Class B sampling tube to move under the card slot. When the sampling arm is pulled out of the card slot, the card plate blocks the Class B sampling tube to detach the Class B sampling tube from the sampling arm.

[0026] Furthermore, the operating mechanism includes left and right slides, front and rear slides, and a lifting seat, and the sampling arm is connected to the lifting seat;

[0027] A linear slide rail is arranged between the left and right slide seats and the crossbeam of the frame, a first screw rod is arranged on the crossbeam of the frame, and the first screw rod passes through the left and right slide seats to drive the left and right slide seats to move;

[0028] A pair of guide rods and a second screw rod are arranged on the left and right slides, and the guide rods and the second screw rod pass through the front and rear slides, and the second screw rod rotates to drive the front and rear slides to move forward and backward on the left and right slides;

[0029] A linear slide rail is arranged between the lifting seat and the front and rear slide seats, a third screw rod is arranged on the front and rear slide seats, the third screw rod passes through the lifting seat, and the third screw rod rotates to drive the lifting seat to move up and down.

[0030] Furthermore, an upper plate is arranged on the left and right slide seats, the upper plate is located above the crossbeam, and a linear slide rail is arranged between the upper plate and the frame crossbeam;

[0031] A lower plate is arranged on the left and right slide seats, the lower plate is located below the cross beam, a pair of rollers is arranged on the lower plate, and the cross beam is clamped between the two rollers.

[0032] Furthermore, it also includes a recovery pipe and a recovery box, wherein the inlet at the upper end of the recovery pipe is located below the card slot and the perforation, and the outlet of the recovery pipe is connected to the recovery box.

[0033] The beneficial effects of the present invention are:

[0034] The reaction cup used in the tube-type luminometer of the present invention has a filter membrane at the bottom. When the reaction cup is washed, liquid can be drained at the bottom of the reaction cup. The drainage of the reaction cup does not require the use of a steel needle or a sampling tube, which completely avoids the use of a steel needle to remove liquid contamination and also avoids the need to consume a large number of tips to remove liquid during the experiment.

[0035] The reaction cup with filter membrane can remove the liquid from the bottom. When using the reaction cup with filter membrane used in this instrument for testing, non-magnetic microsphere reagents can be selected to greatly improve the efficiency of liquid removal in the reaction cup and the test efficiency.

[0036] When the tubular luminometer of the present invention washes the reaction cup, non-magnetic microspheres can be used as microsphere reagents. After the reaction substances are attached to the microspheres, the liquid in the reaction cup can be removed by the "negative pressure + filter membrane" method, and the previous "magnet + steel needle" method is no longer used, making the washing of the reaction cup more efficient. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The present invention is further described below in conjunction with the accompanying drawings.

[0038] Figure 1 It is a schematic diagram of a tubular luminometer of the present invention;

[0039] Figure 2 and Figure 3 is a schematic diagram of the reaction cup;

[0040] Figure 4 It is a schematic diagram of the washing mechanism (with reaction disk);

[0041] Figure 5 is a schematic diagram of the washing mechanism;

[0042] Figure 6 , Figure 7 , Figure 8 is a schematic diagram of the sampling mechanism;

[0043] Fig. 9 , Fig.10 It is the coordination diagram of the reaction disk and reagent disk;

[0044] Fig.11 is a schematic diagram of the reaction disk;

[0045] Fig.12 It is a schematic diagram of the reagent disk;

[0046] Fig.13 , Fig.14is a schematic diagram of the support assembly;

[0047] Fig.15 It is a schematic diagram of the retaining ring;

[0048] Fig.16 It is a schematic diagram of the card board;

[0049] Among them, 1, frame, 11, beam, 12, operating table;

[0050] 2. washing mechanism, 21. drain pipe, 22. injection bracket, 23. injection pipe, 24. upper baffle, 241. avoidance groove;

[0051] 3. reaction cup, 31. cup body, 32. cup base, 33. filter membrane;

[0052] 41. reaction plate, 411. first cup placement hole, 412. second cup placement hole,

[0053] 42. Reagent tray, 421. First reagent rack, 422. Tube holder, 423. Baffle, 424. Second drive motor;

[0054] 43. ring gear, 431. first drive motor;

[0055] 44. support assembly, 441. upper seat, 442. lower seat, 443. rolling ball;

[0056] 51, left and right slide seats, 511, first screw rod, 512, upper plate, 513, lower plate, 514, roller;

[0057] 52, front and rear slide seats, 521, second screw rod, 522, guide rod;

[0058] 53, lifting seat, 531, third screw

[0059] 54. Sampling arm;

[0060] 55. Mounting frame;

[0061] 56, card board, 561, perforation, 562, card slot;

[0062] 61. Class A reagent bottle, 62. Class A sampling tube, 63. Class B sampling tube. DETAILED DESCRIPTION

[0063] The present invention will now be further described in conjunction with specific embodiments. These drawings are simplified schematic diagrams that only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.

[0064] like Figures 1 to 15As shown, a tubular luminometer comprises a frame 1, an operating table 12 is arranged on the frame 1, a reaction tray 41 is arranged on the operating table 12, a circle of first cup placement holes 411 are arranged on the reaction tray 41, each first cup placement hole 411 is suitable for placing a reaction cup 3, and the reaction tray 41 is arranged to rotate horizontally on the operating table 12, suitable for moving each reaction cup 3 on the reaction tray 41 to a washing station in sequence;

[0065] The reaction cup 3 has a liquid inlet at the top and a liquid outlet at the bottom. The liquid outlet is provided with a filter membrane 33. When the reaction cup 3 is at normal pressure, the filter membrane 33 is suitable for supporting the sample reaction liquid in the reaction cup 3.

[0066] The washing mechanism 2 is arranged at the washing station of the operating table 12. When the reaction disk 41 moves the reaction cup 3 to the washing station, the washing mechanism 2 is suitable for forming a sealed connection with the discharge port of the reaction cup 3 to suck out the sample reaction liquid in the reaction cup 3 from the discharge port; and is suitable for adding cleaning liquid to the liquid inlet of the reaction cup 3 to clean the microspheres in the reaction cup 3.

[0067] like Fig.11 As shown, the reaction disk 41 of this embodiment is further provided with a circle of second cup placement holes 412 , which can be used to place dilution cups. The second cup placement holes 412 are located in the inner circle, and the first cup placement holes 411 are located in the outer circle of the reaction disk 41 .

[0068] Specifically, as an optional implementation in this embodiment, Fig. 9 Fig.10 As shown, a reagent disk 42 is arranged on the operating table 12, and the reaction disk 41 is in a circular shape. The reagent disk 42 is horizontally rotatable and arranged in the circular hole of the reaction disk 41. A first reagent rack 421 for placing Class A reagent bottles 61 and tube seats 422 for placing Class A sampling tubes 62 are arranged on the reagent disk 42, and the number of the tube seats 422 corresponds to the number of placement positions for Class A reagent bottles 61 on the first reagent rack 421.

[0069] like Fig.15 As shown, a fence 423 is disposed outside the reaction disk 41 , and the fence 423 is fixedly disposed on the operating table 12 .

[0070] In this embodiment, Fig.12As shown, the first reagent rack 421 is a horizontally arranged circular plate. The first reagent rack 421 is horizontally arranged at the center of the reagent tray 42 through a support rod. Slots 562 for matching with the bottle bodies of the Class A reagent bottles 61 are provided around the first reagent rack 421. A bottle seat is provided on the reagent tray 42 below each slot 562. The bottle seat is used to support the bottom of the Class A reagent bottle 61. Therefore, the bottom of each Class A reagent bottle 61 placed on the reagent tray 42 is in contact with the bottle seat, and the bottle body matches with the slot 562 of the first reagent rack 421.

[0071] Specifically, as an optional implementation in this embodiment, Fig.10 As shown, a plurality of support components 44 are arranged on the operating table 12, and the upper end of the support component 44 and the lower end surface of the reaction disk 41 form a horizontal rolling support;

[0072] A gear ring 43 is fixedly disposed at the lower end of the reaction disk 41, and a first drive motor 431 is fixedly disposed on the operating table 12. The first drive motor 431 is connected to a gear, and the gear is meshed with the gear ring 43. The first drive motor 431 drives the reaction disk 41 to rotate horizontally on each supporting assembly 44 through the gear transmission gear ring 43.

[0073] Similarly, a second drive motor 424 is provided on the operating table 12 , and the second drive motor 424 cooperates with the central transmission of the reagent disk 42 to drive the reagent disk 42 to rotate. At the same time, a vibration motor is provided under the reagent disk 42 to better mix the reagents on the reagent disk 42 .

[0074] Specifically, as an optional implementation in this embodiment, Fig.13 Fig.14 As shown, the support assembly 44 includes an upper seat 441, a lower seat 442 and a rolling ball 443. The lower end of the upper seat 441 is threadedly connected with the upper end of the lower seat 442. A ball groove is defined at the upper end of the upper seat 441, and the rolling ball 443 is disposed in the ball groove.

[0075] The height of the upper seat 441 can be adjusted by rotating the upper seat 441 , thereby controlling the height of the rolling ball 443 , so that each supporting assembly 44 can stably support the reaction disk 41 .

[0076] Specifically, as an optional implementation in this embodiment, Figure 2 Figure 3 As shown, a cup seat 32 is fixedly arranged at the bottom of the reaction cup 3 , the filter membrane 33 is clamped between the cup body 31 of the reaction cup 3 and the cup seat 32 , and a liquid hole is provided on the cup seat 32 , which is suitable for discharging the liquid in the reaction cup 3 .

[0077] In the reaction cup 3 of this embodiment, the filter membrane 33 is fixed to the bottom of the cup body 31 by means of hot-melt welding, and then the cup seat 32 is fixedly arranged under the cup body 31 .

[0078] Specifically, as an optional implementation in this embodiment, Figure 4 Figure 5 As shown, the washing mechanism 2 includes a liquid discharge mechanism and a liquid injection mechanism;

[0079] The liquid discharge mechanism includes a negative pressure pump, a liquid discharge pipe 21, an upper baffle 24 and a push-pull electromagnet;

[0080] The outlet at the lower end of the drain pipe 21 is connected to the negative pressure pump, and the push-pull electromagnet is connected to the drain pipe 21, suitable for driving the drain pipe 21 to move up and down, so that the inlet at the upper end of the drain pipe 21 forms a plug-in fit with the drain port at the bottom of the reaction cup 3, and the upper baffle 24 is fixedly arranged above the washing station, suitable for preventing the reaction cup 3 at the washing station from moving upward.

[0081] In this embodiment, the liquid discharge pipe 21 includes a hose and a hard pipe. The hose is connected to the negative pressure pump and the hard pipe outlet. The hard pipe inlet is used to seal with the bottom of the reaction cup 3. The push-pull electromagnet is connected to the hard pipe to drive the hard pipe to move up and down.

[0082] like Figure 5 As shown, the liquid injection mechanism includes a liquid injection bracket 22, a liquid injection tube 23 and a translation cylinder. The translation cylinder is connected to the liquid injection bracket 22 to drive the liquid injection bracket 22 to translate. The liquid injection tube 23 is arranged on the liquid injection bracket 22. The liquid injection tube 23 is suitable for injecting cleaning liquid into the reaction cup 3 in the washing station.

[0083] The upper baffle plate 24 is provided with an avoidance groove 241 . When cleaning liquid needs to be added, the translation cylinder pushes the injection pipe 23 to the top of the reaction cup 3 of the washing station, and the cleaning liquid enters the reaction cup 3 through the avoidance hole.

[0084] Specifically, as an optional implementation in this embodiment, Figure 6 Figure 7 Figure 8 As shown, a sample loading mechanism is provided on the frame 1;

[0085] The sample adding mechanism includes an operating mechanism, a sampling arm 54, a clamping plate 56, a tube rack for placing a type B sampling tube 63, and a second reagent rack for placing a type B reagent bottle;

[0086] The operating mechanism is suitable for driving the sampling arm 54 to move in up and down, left and right, and front and back directions;

[0087] The sampling arm 54 is suitable for inserting the type B sampling tube 63 on the tube rack;

[0088] like Fig.16 As shown, the clamping plate 56 is fixedly arranged on the operating table 12, and a through hole 561 and a clamping slot 562 are provided at the upper end of the clamping plate 56, and the clamping slot 562 is connected to the through hole 561. The sampling arm 54 is suitable for driving the class B sampling tube 63 to pass through the through hole 561, and the sampling arm 54 can move laterally in the clamping slot 562 to drive the class B sampling tube 63 to move under the clamping slot 562. When the sampling arm 54 is pulled out of the clamping slot 562, the clamping plate 56 blocks the class B sampling tube 63 to detach the class B sampling tube 63 from the sampling arm 54.

[0089] The sampling arm 54 in this embodiment is an existing product, and its working principle and structure are not described in detail here.

[0090] In this embodiment, a Class B reagent rack and a Class B sampling tube 63 placement rack are provided on the operating table 12, and the Class B reagent rack and the Class B sampling tube 63 placement rack are conventional structures; multiple sets of sampling mechanisms are provided on the tube-type luminometer of this embodiment, and the sampling mechanisms of this embodiment are only for the Class B reagent bottles and Class B sampling tubes 63 on the Class B reagent rack.

[0091] Specifically, as an optional implementation in this embodiment, Figure 6 Figure 7 Figure 8 As shown, the operating mechanism includes left and right slides 51, front and rear slides 52, and a lifting seat 53, and the sampling arm 54 is connected to the lifting seat 53;

[0092] A linear slide rail is arranged between the left and right slide seats 51 and the cross beam 11 of the frame 1. A first screw rod 511 is arranged on the cross beam 11 of the frame 1. The first screw rod 511 passes through the left and right slide seats 51 to drive the left and right slide seats 51 to move.

[0093] A pair of guide rods 522 and a second screw rod 521 are disposed on the left and right slides 51. The guide rods 522 and the second screw rod 521 pass through the front and rear slides 52. The second screw rod 521 rotates to drive the front and rear slides 52 to move forward and backward on the left and right slides 51.

[0094] A linear guide rail is arranged between the lifting seat 53 and the front and rear slide seats 52 . A third screw rod 531 is arranged on the front and rear slide seats 52 . The third screw rod 531 passes through the lifting seat 53 . The third screw rod 531 rotates to drive the lifting seat 53 to move up and down.

[0095] In this embodiment, a mounting frame 55 is provided on the left and right slides 51, and the guide rod 522 and the second screw rod 521 are connected to the mounting frame 55. The entire mounting frame 55 and the left and right slides 51 are an integrated structure. The function of the mounting frame 55 is to install the guide rod 522 and the second screw rod 521 on the left and right slides 51.

[0096] Specifically, as an optional implementation in this embodiment, Figure 6 As shown, an upper plate 512 is disposed on the left and right slide seats 51, and the upper plate 512 is located above the crossbeam 11, and a linear slide rail is disposed between the upper plate 512 and the crossbeam 11 of the frame 1;

[0097] A lower plate 513 is disposed on the left and right slide seats 51 . The lower plate 513 is located below the cross beam 11 . A pair of rollers 514 is disposed on the lower plate 513 . The cross beam 11 is clamped between the two rollers 514 .

[0098] By means of the upper plate 512 , the lower plate 513 and a pair of rollers 514 on the lower plate 513 , the left and right slide seats 51 can stably move left and right on the horizontal frame.

[0099] Specifically, as an optional implementation in this embodiment, it also includes a recovery pipe and a recovery box, the inlet at the upper end of the recovery pipe is located below the card slot 562 and the perforation 561, and the outlet of the recovery pipe is connected to the recovery box.

[0100] During operation, the dilution cup is placed in the second cup hole 412 of the reaction disk 41, and the reaction cup 3 with the filter membrane 33 is placed in the first cup hole 411; the sampling arm 54 adds the type A reagent to the reaction cup 3 with the filter membrane 33, and the sample is diluted in the dilution cup of the reaction disk 41 and then added to the reaction cup 3 with the filter membrane 33 for mixing reaction;

[0101] After the reaction is completed, the reaction tray 41 moves to the washing station. At this time, the reaction cup 3 is located below the upper baffle 24. The push-pull electromagnet drives the drain pipe 21 to move upward, so that the drain pipe 21 is sealed with the bottom of the reaction cup 3. The negative pressure pump works to remove the reaction liquid of the reaction cup 3. The entire removal process does not require the use of a steel needle or a sampling tube, which completely avoids pollution and sampling tube loss. After removal, there will be microspheres in the reaction cup 3, and the microspheres will carry reactive substances. The cleaning liquid is injected into the reaction cup 3 through the liquid injection mechanism, and the cleaning liquid is sucked away by the negative pressure pump. Repeatedly, until the microspheres are cleaned, the next step can be entered: add the B-type reagent to the reaction cup 3 with the filter membrane 33 for mixing reaction. After the reaction is completed, the next step of the luminescence test can be entered. The luminescence test is not described in detail in this embodiment.

[0102] The Class A reagent bottles 61 and Class A sampling tubes 62 on the Class A reagent tray 42 are "dedicated bottles for dedicated purposes" to avoid cross contamination. The sampling arm 54 on the Class B reagent tray 42 can move to the perforation 561 and the slot 562 of the clamping plate 56 after using up the Class B sampling tube 63, and the Class B sampling tube 63 can be detached from the sampling arm 54 through the clamping plate 56, making it easier for the sampling arm 54 to connect a new Class B sampling tube 63.

[0103] The advantage of the tube-type luminometer of the present invention is that it adopts a reaction cup 3 with a filter membrane 33 of a new structure, and the bottom drainage is adopted for washing the reaction cup 3. The whole washing process does not require the use of a steel needle and a sampling tube, thereby avoiding cross contamination and sampling tube loss during the test.

[0104] The circular structures of the reagent disk 42 and the reaction disk 41 can be designed with more cup placement holes, so that more reagent bottles can be placed, and the space utilization is more reasonable.

[0105] The sampling tube in the sampling mechanism can be easily detached through the clamping plate 56, so that the sampling mechanism can perform sampling work quickly and efficiently.

[0106] Based on the above ideal embodiments of the present invention, the relevant staff can make various changes and modifications without departing from the technical concept of the present invention through the above description. The technical scope of the present invention is not limited to the contents of the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A tubular luminometer, characterized in that: include A frame, an operating table is arranged on the frame, a reaction disc is arranged on the operating table, a circle of first cup placement holes is arranged on the reaction disc, each of the first cup placement holes is suitable for placing a reaction cup, and the reaction disc is arranged to rotate horizontally on the operating table, suitable for moving each reaction cup on the reaction disc to a washing station in sequence; A reaction cup, wherein a liquid inlet is provided at the upper end of the reaction cup, a liquid discharge port is provided at the bottom of the reaction cup, and a filter membrane is arranged at the liquid discharge port; when the reaction cup is at normal pressure, the filter membrane is suitable for supporting the sample reaction liquid in the reaction cup; The washing mechanism is arranged at the washing station of the operating table. When the reaction tray moves the reaction cup to the washing station, the washing mechanism is adapted to form a sealed connection with the liquid discharge port of the reaction cup to suck out the sample reaction liquid in the reaction cup from the liquid discharge port; and is adapted to add a cleaning liquid to the liquid inlet of the reaction cup to clean the microspheres in the reaction cup; A reagent tray is arranged on the operating table, the reaction tray is in a circular shape, the reagent tray is horizontally rotatable and arranged in the circular hole of the reaction tray, a first reagent rack for placing Class A reagent bottles and tube holders for placing Class A sampling tubes are arranged on the reagent tray, and the number of the tube holders corresponds to the number of placement positions for Class A reagent bottles on the first reagent rack; A cup seat is arranged at the bottom of the reaction cup, the filter membrane is clamped between the cup body of the reaction cup and the cup seat, and a liquid hole is arranged on the cup seat, which is suitable for discharging the liquid in the reaction cup.

2. The tubular luminometer according to claim 1, characterized in that: A plurality of support components are arranged on the operating table, and the upper ends of the support components and the lower end surface of the reaction disk form a horizontal rolling support; A gear ring is fixedly arranged at the lower end of the reaction disk, and a first driving motor is fixedly arranged on the operating table. The first driving motor is connected to a gear, and the gear is meshed with the gear ring. The first driving motor drives the gear ring through the gear to drive the reaction disk to rotate horizontally on each supporting assembly.

3. The tubular luminometer according to claim 2, characterized in that: The support assembly comprises an upper seat, a lower seat and a rolling ball. The lower end of the upper seat is threadedly connected with the upper end of the lower seat. A ball groove is provided at the upper end of the upper seat, and the rolling ball is arranged in the ball groove.

4. The tubular luminometer according to claim 1, characterized in that: The washing mechanism comprises a liquid discharging mechanism and a liquid injection mechanism; The liquid discharge mechanism comprises a negative pressure pump, a liquid discharge pipe, an upper baffle and a push-pull electromagnet; The outlet at the lower end of the liquid discharge pipe is connected to the negative pressure pump, and the push-pull electromagnet is connected to the liquid discharge pipe, and is suitable for driving the liquid discharge pipe to move up and down, so that the inlet at the upper end of the liquid discharge pipe forms a plug-in fit with the liquid discharge port at the bottom of the reaction cup, and the upper baffle is fixedly arranged above the washing station, and is suitable for preventing the reaction cup at the washing station from moving upward; The injection mechanism includes an injection bracket, an injection tube and a translation cylinder. The translation cylinder is connected to the injection bracket to drive the injection bracket to translate. The injection tube is arranged on the injection bracket and is suitable for injecting cleaning liquid into the reaction cup at the washing station.

5. The tubular luminometer according to claim 1, characterized in that: The rack is provided with a sample loading mechanism; The sample loading mechanism includes an operating mechanism, a sampling arm, a card plate, a tube rack for placing Class B sampling tubes, and a second reagent rack for placing Class B reagent bottles; wherein The operating mechanism is suitable for driving the sampling arm to move in up and down, left and right, and front and back directions; The sampling arm is suitable for inserting a type B sampling tube on the tube rack; The card plate is fixed on the operating table, and a through hole and a card slot are provided on the upper end of the card plate. The card slot is connected to the through hole. The sampling arm is suitable for driving the Class B sampling tube to pass through the through hole, and the sampling arm can move laterally in the card slot to drive the Class B sampling tube to move under the card slot. When the sampling arm is pulled out of the card slot, the card plate blocks the Class B sampling tube to detach the Class B sampling tube from the sampling arm.

6. The tubular luminometer according to claim 5, characterized in that: The operating mechanism includes left and right slides, front and rear slides, and a lifting seat, and the sampling arm is connected to the lifting seat; A linear slide rail is arranged between the left and right slide seats and the crossbeam of the frame, a first screw rod is arranged on the crossbeam of the frame, and the first screw rod passes through the left and right slide seats to drive the left and right slide seats to move; A pair of guide rods and a second screw rod are arranged on the left and right slides, and the guide rods and the second screw rod pass through the front and rear slides, and the second screw rod rotates to drive the front and rear slides to move forward and backward on the left and right slides; A linear slide rail is arranged between the lifting seat and the front and rear slide seats, a third screw rod is arranged on the front and rear slide seats, the third screw rod passes through the lifting seat, and the third screw rod rotates to drive the lifting seat to move up and down.

7. The tubular luminometer according to claim 6, characterized in that: An upper plate is arranged on the left and right slide seats, the upper plate is located above the crossbeam, and a linear slide rail is arranged between the upper plate and the frame crossbeam; A lower plate is arranged on the left and right slide seats, the lower plate is located below the cross beam, a pair of rollers is arranged on the lower plate, and the cross beam is clamped between the two rollers.

8. The tubular luminometer according to claim 5, characterized in that: It also includes a recovery pipe and a recovery box. The inlet at the upper end of the recovery pipe is located below the card slot and the perforation, and the outlet of the recovery pipe is connected to the recovery box.

Citation Information

Patent Citations

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