An epilepsy monitoring device and a method for reducing the false positive rate of epilepsy monitoring

Abstract

The present invention discloses an epilepsy monitoring device and a method for reducing the false positive rate of epilepsy monitoring. The monitoring device includes: an information collector, an information processor, and a pulse generator; the information collector is used to collect the physiological signals and acceleration signals of a patient, and the physiological signals include body temperature signals and heart rate signals; the information processor analyzes and processes the acceleration signals and body temperature signals to obtain the motion state information of the patient, analyzes and processes the heart rate signals to obtain the heart rate state information of the patient, compares the motion state information and the heart rate state information with corresponding determination thresholds, determines whether to generate an instruction to turn on pulse stimulation according to the comparison result, and sends the instruction to the pulse generator, and the pulse generator turns on pulse stimulation at an appropriate time according to the instruction. According to the present invention, the pulse generator can turn on pulse stimulation as needed, further reducing the energy consumption of the in-vivo implant unit.

Description

Technical Field

[0001] The present invention belongs to the medical field and relates to an epilepsy monitoring device and a method for reducing the false positive rate of epilepsy monitoring. Background Art

[0002] Currently, there are some vagus nerve stimulators that predict epilepsy by monitoring heart rate changes and release pulse stimuli to weaken or directly relieve the threat of epileptic seizures. However, since it is impossible to avoid the influence of movement on heart rate changes, it may cause the stimulation to be automatically turned on when epilepsy does not occur, that is, the false positive rate of epilepsy monitoring is relatively high. This will not only increase the power consumption of the stimulator and reduce the service life of the stimulator (for rechargeable stimulators, it will shorten the charging interval), but also the multiple high-dose stimulations caused by false positives may cause damage to the patient's nerves.

[0003] Purpose of the Invention

[0004] The object of the present invention is to overcome the problems existing in the prior art. By comprehensively considering the patient's heart rate data, acceleration data, body temperature data, etc., an epilepsy monitoring device and a method for reducing the false positive rate of epilepsy monitoring are provided, which can extend the service life of the stimulator (for rechargeable stimulators, it can extend the charging interval) and reduce the damage to the patient's nerves. Summary of the Invention

[0005] According to one aspect of the present invention, an epilepsy monitoring device is provided, including: an information collector, an information processor, and a pulse generator;

[0006] The information collector is used to collect the physiological signals and acceleration signals of the patient, and the physiological signals include body temperature signals and heart rate signals;

[0007] The information processor is used to process the acceleration signal and body temperature signal to obtain the patient's motion state information, compare the motion state information with a set motion determination threshold to determine whether the motion is invalid or valid; process the heart rate signal to obtain the patient's heart rate state information; determine whether to generate an instruction to turn on the pulse stimulation according to whether the heart rate state information exceeds the heart rate threshold and combine the determination of invalid or valid motion, and send the instruction to the pulse generator;

[0008] The pulse generator turns on the pulse stimulation according to the instruction.

[0009] Preferably, the motion state information includes acceleration information and body temperature information, and the determination threshold includes an acceleration threshold and a body temperature threshold.

[0010] More preferably, the acceleration threshold includes an acceleration threshold one and an acceleration threshold two, which are used to determine the motion state in combination with the acceleration information.

[0011] More preferably, the exercise state includes static, walking, low-intensity exercise, and high-intensity exercise.

[0012] More preferably, the body temperature thresholds include a first body temperature threshold and a second body temperature threshold, which are used to combine the body temperature information and the acceleration information to determine whether the exercise is ineffective or effective.

[0013] More preferably, the exercise state information further includes time information, and the determination threshold further includes a time threshold, which are used to combine the time information, the body temperature information, and the acceleration information to determine whether the exercise is ineffective or effective.

[0014] Preferably, the heart rate state information is the heart rate increase value.

[0015] More preferably, the acceleration threshold is set according to the increase amplitude of the patient's heart rate. The first acceleration threshold is the minimum acceleration corresponding to the patient's heart rate increasing to 140%-160% of the patient's resting heart rate, and the second acceleration threshold is the minimum acceleration corresponding to the patient's heart rate increasing to 190%-210% of the patient's resting heart rate.

[0016] According to another aspect of the present invention, there is provided a method for reducing the false positive rate of epilepsy monitoring using the above-mentioned epilepsy monitoring device, including the following steps:

[0017] Step 1: Collect the patient's heart rate signal and acceleration signal through the information collector, analyze the acceleration information through the information processor, and identify the patient's exercise state. When the acceleration information is less than the first acceleration threshold, determine that the exercise state is the first exercise state, and proceed to Step 2; when the acceleration information is greater than the second acceleration threshold, determine that the exercise state is the third exercise state, and proceed to Step 5; otherwise, determine that the exercise state is the second exercise state, and proceed to Step 4, where the first acceleration threshold and the second acceleration threshold are set according to the patient's heart rate, and the first acceleration threshold is less than the second acceleration threshold;

[0018] Step 2: Determine whether timing has been performed. If not, proceed to Step 3; otherwise, proceed to Step 6;

[0019] Step 3: Determine that the exercise state is the initial first exercise state, do not start body temperature collection, record the exercise as ineffective, and proceed to Step 7;

[0020] Step 4: Perform timing and body temperature collection. If the timing exceeds the first time threshold and the body temperature information exceeds the first body temperature threshold, record the exercise as effective, and proceed to Step 7;

[0021] Step 5: Perform timing and body temperature collection. If the timing exceeds the second time threshold and the body temperature information exceeds the second body temperature threshold, record the exercise as effective, and proceed to Step 7;

[0022] Step 6: Determine that the motion state is the first motion state returned from the second or third motion state, and do not start body temperature acquisition. When the timing exceeds the third time threshold, the motion is recorded as invalid and the timing stops; otherwise, the motion is recorded as valid and proceed to Step 7;

[0023] Step 7: If the patient's heart rate status information exceeds the heart rate threshold and the motion is recorded as invalid, generate an instruction to turn on the pulse stimulation and return to Step 1.

[0024] Preferably, in the above Step 1, it also includes determining whether the motion state has changed. If it has changed, clear the original timing and start timing again; otherwise, continue timing.

[0025] Compared with the prior art, the innovation of the present invention lies in combining epilepsy detection with the patient's motion state, reducing the false positive rate of epilepsy detection. The present invention has the following advantages:

[0026] 1. The present invention can determine the patient's motion state based on the patient's acceleration data and body temperature data. When the patient's heart rate data exceeds the set threshold, it is necessary to combine the patient's motion state to determine whether to turn on the stimulation, avoiding mis-turning on the stimulation due to the patient's motion causing an increase in heart rate, reducing the false positive rate of epilepsy detection and damage to the patient's nerves, and at the same time saving the power of the pulse stimulator.

[0027] 2. The acceleration threshold setting of the present invention varies from person to person, and different thresholds can be set for different patients, which can not only ensure the accuracy of motion intensity monitoring but also better conform to personal habits.

[0028] 3. The present invention only turns on body temperature monitoring when the acceleration exceeds the first threshold, which not only conforms to the actual use scenario but also can further save the power of the stimulator.

[0029] 4. The present invention sets different timing time thresholds and body temperature thresholds for different intensities of motion, which can better conform to the actual use scenario and improve the monitoring efficiency on the basis of ensuring accurate monitoring of motion intensity. Description of the Drawings

[0030] Figure 1 is a schematic structural diagram of an epilepsy monitoring device in an embodiment of the present invention;

[0031] Figure 2 is a method for reducing the false positive rate of epilepsy monitoring of the epilepsy monitoring device in an embodiment of the present invention. Detailed Embodiments

[0032] The present invention will be described in detail below with reference to the accompanying drawings.

[0033] Figure 1It is a schematic structural diagram of the epilepsy monitoring device described in the present invention. The device is used to monitor the onset state of a patient and includes: an information collector, an information processor, and a pulse generator; the information collector may include: an acceleration sensor, a body temperature sensor, and a heart rate sensor, and is used to collect the physiological signals and acceleration signals of the patient, and the physiological signals include body temperature signals and heart rate signals; the information processor analyzes and processes the acceleration signals and body temperature signals to obtain the motion state information of the patient, analyzes and processes the heart rate signals to obtain the heart rate state information of the patient, compares the motion state information and the heart rate state information with corresponding determination thresholds, determines whether to generate an instruction to turn on pulse stimulation according to the comparison result, and sends the instruction to the pulse generator, and the pulse generator turns on pulse stimulation at an appropriate time according to the instruction.

[0034] In a preferred embodiment, all units of the device can be implanted in the body, or a part is implanted in the body and a part is placed outside the body. For example, the pulse generator is implanted in the body, and the information collector and the information processor are used as external units to monitor physiological signals and acceleration signals in real time. When the external unit generates an instruction to turn on pulse stimulation according to the judgment, it communicates with the internal pulse generator and sends the instruction to the pulse generator, so that the pulse generator can turn on pulse stimulation as needed, further reducing the energy consumption of the internal implanted unit.

[0035] In a preferred embodiment, the motion state information at least includes: acceleration information, body temperature information, and the corresponding motion determination thresholds at least include: an acceleration threshold, a body temperature threshold. Among them, the acceleration threshold at least includes: an acceleration threshold one and an acceleration threshold two, and is used to judge the motion state in combination with the acceleration information. Among them, the acceleration threshold one is less than the acceleration threshold two. Specifically, when the acceleration information is less than or equal to the acceleration threshold one, the motion state is judged to be static or walking; when the acceleration information is greater than the acceleration threshold one and less than the acceleration threshold two, the motion state is judged to be low-intensity exercise; when the acceleration information is greater than or equal to the acceleration threshold two, the motion state is judged to be high-intensity exercise. The body temperature threshold at least includes: a body temperature threshold one and a body temperature threshold two, and is used to judge whether the motion is invalid or valid in combination with the body temperature information and the acceleration information. Among them, the body temperature threshold two is greater than the body temperature threshold one. Specifically, when the motion state is low-intensity exercise, if the body temperature information is greater than the body temperature threshold one, the motion is judged to be valid, otherwise the motion is judged to be invalid; when the motion state is high-intensity exercise, if the body temperature information is greater than the body temperature threshold two, the motion is judged to be valid, otherwise the motion is judged to be invalid.

[0036] In a preferred embodiment, the acceleration threshold can be set according to the increase in the patient's heart rate. The first acceleration threshold is the minimum acceleration corresponding to the patient's heart rate increasing to 140%-160% of the patient's resting heart rate, and the second acceleration threshold is the minimum acceleration corresponding to the patient's heart rate increasing to 190%-210% of the patient's resting heart rate.

[0037] In a preferred embodiment, the motion state information further includes time information, and the corresponding motion determination threshold further includes: a time threshold. The time threshold at least includes: a first time threshold, a second time threshold, and a third time threshold, which are used to determine whether the motion is invalid or valid by combining the time information, body temperature information, and acceleration information. Among them, the second time threshold is less than the first time threshold. Specifically, when the motion state is low-intensity exercise, timing and body temperature collection are started. When the timing exceeds the first time threshold and the body temperature information exceeds the first body temperature threshold, the motion is determined to be valid; otherwise, the motion is determined to be invalid. When the motion state is high-intensity exercise, timing and body temperature collection are started. When the timing exceeds the second time threshold and the body temperature information exceeds the second body temperature threshold, the motion is determined to be valid; otherwise, the motion is determined to be invalid. When the motion state returns from "low-intensity exercise" or "high-intensity exercise" to "rest or walking", the body temperature collection is stopped and the timing is restarted. When the timing exceeds the third time threshold, the motion is determined to be invalid; otherwise, the motion is determined to be valid. If the time interval between "rest or walking" and other motion states exceeds the third time threshold, it can be considered the initial "rest or walking". In this state, the timing is turned off, the body temperature collection is stopped, and the motion is determined to be invalid. It should be noted that if the motion state changes, the original timing is cleared and restarted.

[0038] In a preferred embodiment, the heart rate state information at least includes: the heart rate increase value, and the corresponding determination threshold further includes: a heart rate threshold. The epilepsy monitoring device determines whether to generate an instruction to start pulse stimulation according to whether the heart rate increase value exceeds the heart rate threshold and in combination with the determination of whether the motion is invalid or valid in the above embodiments. Specifically, if the patient's heart rate state information exceeds the heart rate threshold and the motion is determined to be invalid, an instruction to start pulse stimulation is generated; if the patient's heart rate state information does not exceed the heart rate threshold, an instruction not to start pulse stimulation or an instruction to not start pulse stimulation is generated; if the patient's heart rate state information exceeds the heart rate threshold and the motion is determined to be valid, an instruction not to start pulse stimulation or an instruction to not start pulse stimulation is generated.

[0039] In a preferred embodiment, the above acceleration information, body temperature information, and heart rate state information should take the average value within a certain sliding window interval.

[0040] The method for reducing the false positive rate of epilepsy monitoring of the epilepsy monitoring device according to the present invention includes the following steps:

[0041] Step 1: Collect the patient's heart rate signal and acceleration signal through the information collector, analyze the acceleration information through the information processor, and identify the patient's motion state. When the acceleration information is less than or equal to the first acceleration threshold, determine that the motion state is Motion State 1 and proceed to Step 2; when the acceleration information is greater than or equal to the second acceleration threshold, determine that the motion state is Motion State 3 and proceed to Step 5; otherwise, determine that the motion state is Motion State 2 and proceed to Step 4. Herein, the first acceleration threshold and the second acceleration threshold are set according to the patient's heart rate, and the first acceleration threshold is less than the second acceleration threshold.

[0042] Further, in Step 1 above, Motion State 1 can be static or walking, Motion State 2 can be low-intensity exercise, and Motion State 3 can be high-intensity exercise.

[0043] Step 2: Determine whether timing has been performed. If not, proceed to Step 3; otherwise, proceed to Step 6.

[0044] Step 3: Determine that the motion state is the initial Motion State 1, do not start body temperature collection, record the motion as invalid, and proceed to Step 7.

[0045] Step 4: Perform timing and body temperature collection. If the timing exceeds the first time threshold and the body temperature information exceeds the first body temperature threshold, record the motion as valid and proceed to Step 7.

[0046] Step 5: Perform timing and body temperature collection. If the timing exceeds the second time threshold and the body temperature information exceeds the second body temperature threshold, record the motion as valid and proceed to Step 7.

[0047] Step 6: Determine that the motion state is Motion State 1 returned from Motion State 2 or Motion State 3, do not start body temperature collection. When the timing exceeds the third time threshold, record the motion as invalid and stop timing; otherwise, record the motion as valid and proceed to Step 7.

[0048] Step 7: If the patient's heart rate status information exceeds the heart rate threshold and the motion is recorded as invalid, generate an instruction to start pulse stimulation and return to Step 1.

[0049] Further, in Step 1 above, it also includes determining whether the motion state has changed. If it has changed, clear the original timing and start timing again; otherwise, continue timing.

[0050] Further, before Step 1 above, it also includes the initialization of the first acceleration threshold and the second acceleration threshold, specifically including:

[0051] Step 0: Collect the resting heart rate of the patient, plot the acceleration-real-time heart rate curve, and find the minimum acceleration corresponding to the situation where the heart rate increases to 140%-160% of the resting heart rate, which is the first acceleration threshold; find the minimum acceleration corresponding to the situation where the heart rate increases to 190%-210% of the resting heart rate, which is the second acceleration threshold. Among them, the real-time heart rate should be the average value within a certain sliding window interval. In order to balance the real-time performance and accuracy of heart rate collection for the sliding window interval, in this embodiment, preferably, the sliding window interval is set to 10 heart rate values.

[0052] The above embodiments are merely examples given for clear illustration and not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to enumerate all implementation manners here. And the obvious changes or modifications derived therefrom still fall within the protection scope of the present invention.

Claims

1. An epilepsy monitoring device, characterized in that, The monitoring device includes: an information collector, an information processor, and a pulse generator; The information collector is used to collect the physiological signals and acceleration signals of the patient, and the physiological signals include body temperature signals and heart rate signals; The information processor is used to process the acceleration signal and body temperature signal to obtain the motion state information of the patient, compare the motion state information with the set motion determination threshold to determine whether the motion is invalid or valid; process the heart rate signal to obtain the heart rate state information of the patient; according to whether the heart rate state information exceeds the heart rate threshold and combined with the determination of invalid or valid motion, determine whether to generate an instruction to turn on pulse stimulation, avoid accidentally turning on stimulation due to the increase in the patient's heart rate caused by the patient's motion, and send the instruction to the pulse generator; The pulse generator turns on pulse stimulation according to the instruction; The motion state information includes acceleration information and body temperature information, and the determination threshold includes an acceleration threshold and a body temperature threshold; The acceleration threshold includes a first acceleration threshold and a second acceleration threshold, which are used to judge the motion state in combination with the acceleration information; The motion state includes static, walking, low-intensity exercise, and high-intensity exercise.

2. The epilepsy monitoring device according to claim 1, characterized in that The body temperature threshold includes a first body temperature threshold and a second body temperature threshold, which are used to judge whether the motion is invalid or valid in combination with the body temperature information and acceleration information.

3. The epilepsy monitoring device according to claim 1, characterized in that, The motion state information further includes time information, and the determination threshold further includes a time threshold, which is used to judge whether the motion is invalid or valid in combination with the time information, body temperature information, and acceleration information.

4. The epilepsy monitoring device according to claim 1, characterized in that, The heart rate state information is the heart rate increase value.

5. The epilepsy monitoring device according to claim 1, characterized in that The acceleration threshold is set according to the increase amplitude of the patient's heart rate. The first acceleration threshold is the minimum acceleration corresponding to when the patient's heart rate increases to 140%-160% of the patient's resting heart rate, and the second acceleration threshold is the minimum acceleration corresponding to when the patient's heart rate increases to 190%-210% of the patient's resting heart rate.

6. A method for reducing the false positive rate of epilepsy monitoring using the epilepsy monitoring device according to any one of claims 1-5, characterized in that, It includes the following steps: Step 1: Collect the heart rate signal and acceleration signal of the patient through the information collector, analyze the acceleration information through the information processor and identify the motion state of the patient. When the acceleration information is less than or equal to the first acceleration threshold, judge the motion state as motion state one and enter step 2; when the acceleration information is greater than or equal to the second acceleration threshold, judge the motion state as motion state three and enter step 5; otherwise, judge the motion state as motion state two and enter step 4, where the first acceleration threshold and the second acceleration threshold are set according to the patient's heart rate, and the first acceleration threshold is less than the second acceleration threshold; Step 2: Judge whether timing has been carried out. If not, enter step 3, otherwise enter step 6; Step 3: Judge that the motion state is the initial motion state one, do not turn on body temperature collection, record the motion as invalid, and enter step 7; Step 4: Carry out timing and body temperature collection. If the timing exceeds the first time threshold and the body temperature information exceeds the first body temperature threshold, record the motion as valid and enter step 7; Step 5: Carry out timing and body temperature collection. If the timing exceeds the second time threshold and the body temperature information exceeds the second body temperature threshold, record the motion as valid and enter step 7; Step 6: Determine that the motion state is the first motion state returned from the second or third motion state. Do not start body temperature collection. When the timing exceeds the third time threshold, the motion is recorded as invalid and the timing stops; otherwise, the motion is recorded as valid and proceed to Step 7; Step 7: If the patient's heart rate status information exceeds the heart rate threshold and the motion is recorded as invalid, generate an instruction to turn on the pulse stimulation and return to Step 1.

7. The method according to claim 6, characterized in that, In the above Step 1, it also includes determining whether the motion state has changed. If it has changed, clear the original timing and start a new timing; otherwise, continue the timing.

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