Transcranial magnetic stimulation intervention device

Abstract

The present invention relates to a transcranial magnetic stimulation intervention device, comprising the following steps: obtaining the near-infrared change amplitude of the target brain area before and after transcranial magnetic stimulation; judging whether the near-infrared change amplitude of the target brain area exceeds a set threshold; if so, matching the transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area; stimulating the target brain area according to the transcranial magnetic stimulation parameters. In addition, a transcranial magnetic stimulation intervention device is also provided. The above-mentioned transcranial magnetic stimulation intervention device, through transcranial magnetic stimulation of the target brain area, including the motor brain area and the non-motor brain area, can intuitively show the changes in the target brain area being intervened by monitoring the near-infrared change amplitude of the target brain area, and can match the corresponding transcranial magnetic stimulation scheme according to the near-infrared change amplitude before and after stimulation, so as to achieve the effect of stimulation feedback judgment.

Description

Technical Field

[0001] The present invention relates to the field of time and technology, and in particular to a transcranial magnetic stimulation intervention device. Background Art

[0002] Transcranial Magnetic Stimulation (TMS) technology is a magnetic stimulation technology that uses pulsed magnetic fields to act on the central nervous system (mainly the brain), changing the membrane potential of cortical nerve cells, generating induced currents, affecting brain metabolism and neural electrical activity, and thus causing a series of physiological and biochemical reactions.

[0003] Transcranial magnetic stimulation (TMS) uses Faraday's principle of electromagnetic induction to induce current in the brain. In short, the basic principle of TMS is divided into two parts. First, the control system instructs the host to release current through a multi-wound coil. The rapid change in current generates a circular magnetic field perpendicular to the plane of the coil. Second, the circular magnetic field passes unimpeded through the skull, using the intracranial brain parenchyma as a conductive medium, generating a circular induced microcurrent parallel to the coil but in the opposite direction. This current has the effect of modulating neural activity and the local microenvironment.

[0004] Transcranial magnetic stimulation technology regulates local cortical excitability through circular microcurrents generated in the skull. Currently, the treatment of motor dysfunction through transcranial magnetic stimulation is mainly focused on the primary motor cortex, and the main observation indicator is MEP (motor evoked potential). When the therapist uses transcranial magnetic stimulation to treat motor dysfunction, the movement of the target muscle can be used to determine whether the target area is stimulated. However, when transcranial magnetic stimulation intervenes in non-motor brain areas, there is no clear indicator to intuitively show whether transcranial magnetic stimulation intervenes in the target cortex. In addition, transcranial magnetic stimulation activates the cortex differently at different stimulation intensities and frequencies, and the degree of activation at the same intensity and frequency varies among different individuals. Currently, there is no effective equipment to solve the problem of individualized transcranial magnetic stimulation intervention. Summary of the Invention

[0005] Based on this, it is necessary to provide a transcranial magnetic stimulation intervention device that can intuitively show whether transcranial magnetic stimulation has intervened in the target cortex, in order to address the problem that there is no clear indicator to intuitively show whether transcranial magnetic stimulation has intervened in the target cortex when transcranial magnetic stimulation intervenes in non-motor brain areas.

[0006] A transcranial magnetic stimulation intervention device, comprising

[0007] An acquisition module is used to obtain the near-infrared change amplitude of the target brain area before and after transcranial magnetic stimulation;

[0008] a control module, configured to determine whether the near-infrared variation amplitude of the target brain area exceeds a set threshold, and when the near-infrared variation amplitude exceeds the set threshold, to match the transcranial magnetic stimulation parameters corresponding to the near-infrared variation amplitude of the target brain area; and

[0009] A transcranial magnetic stimulation module is used to perform transcranial magnetic stimulation on the target brain area according to the transcranial magnetic stimulation parameters.

[0010] Furthermore, the acquisition module is also used to obtain the near-infrared change amplitude of the entire brain area before and after transcranial magnetic stimulation; the control module is also used to compare whether the near-infrared change amplitude of the target brain area exceeds the set threshold with the near-infrared change amplitude of the entire brain area as a reference.

[0011] Furthermore, the control module is also used to monitor the real-time change amplitude of the near-infrared of the target brain area and adjust the transcranial magnetic stimulation parameters according to the real-time change amplitude.

[0012] Furthermore, the control module pre-stores transcranial magnetic stimulation parameters corresponding to the amplitude of near-infrared changes in the target brain area.

[0013] Furthermore, it also includes a near-infrared signal generating module, which is used to emit near-infrared signals.

[0014] The above-mentioned transcranial magnetic stimulation intervention device can intuitively show the changes in the target brain area being intervened by transcranial magnetic stimulation of the target brain area, including the motor brain area and the non-motor brain area, by monitoring the near-infrared change amplitude of the target brain area, and can match the corresponding transcranial magnetic stimulation plan according to the near-infrared change amplitude before and after stimulation to achieve the effect of stimulation feedback judgment. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a flow chart of a transcranial magnetic stimulation intervention method according to one embodiment;

[0016] Figure 2 This is the schematic diagram of functional near-infrared monitoring;

[0017] Figure 3 Schematic diagram of a transcranial magnetic stimulation intervention device according to an embodiment. DETAILED DESCRIPTION

[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0019] like Figure 1 As shown, in one embodiment, a transcranial magnetic stimulation intervention method includes the following steps:

[0020] Step S110, obtaining the near-infrared change amplitude of the target brain area before and after transcranial magnetic stimulation. Functional near-infrared spectroscopy (fNIRS) assesses neural activity through optical signal changes, which has two core principles. Figure 2 The first core principle is light scattering and absorption. After near-infrared light passes through the skull via the transmitting probe, it is partially absorbed by the brain's contents, while the remaining light is scattered. Ultimately, the light forms an arc-shaped "light path" within the brain, returning to the scalp surface where it is received by the receiving probe. Because HBO (oxyhemoglobin), HBR (deoxyhemoglobin), and water absorb light to varying degrees, analyzing the intensity of the scattered light can reveal changes in hemoglobin levels in the area along the "light path." The second core principle is neurovascular coupling. Neuroscience research has demonstrated that changes in neural activity are positively correlated with changes in the surrounding capillaries. When neural activity is high, the surrounding capillaries dilate, increasing oxygenated hemoglobin, and vice versa. fNIRS can monitor changes in cortical hemodynamics across the entire head, thereby reflecting changes in cortical neural activity.

[0021] Step S120, determine whether the near-infrared change amplitude of the target brain area exceeds the set threshold. If so, proceed to step S130. Because the activation degree of transcranial magnetic stimulation in different individuals is different, in a preferred embodiment, the near-infrared change amplitude of the whole brain area before and after transcranial magnetic stimulation is obtained, and the near-infrared change amplitude of the whole brain area is used as a reference to compare whether the near-infrared change amplitude of the target brain area exceeds the set threshold. For example, when the change amplitude of the near-infrared signal of the target brain area exceeds 10% of the change amplitude of the whole brain signal, the stimulation is deemed effective. If not, that is, the near-infrared change amplitude of the target brain area does not exceed the set threshold, an alarm signal is issued, and transcranial magnetic stimulation is enhanced, and the near-infrared change amplitude of the target brain area is continuously monitored. For example, when the change amplitude of the near-infrared signal of the target brain area does not exceed 10% of the change amplitude of the whole brain signal, the stimulation is deemed invalid, and the system can indicate that the stimulation is invalid by lighting a red light to remind the operator to readjust.

[0022] Step S130, matching the transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area. Transcranial magnetic stimulation parameters are usually intensity and frequency. Different transcranial magnetic stimulation intensities and frequencies have different activation effects on the cortex. Based on the analysis of near-infrared signals, an internal database is established to pre-store transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area. According to the pre-stored parameters, the transcranial magnetic stimulation device is driven to provide targeted treatment to the patient. At the same time, the stimulation mode is adjusted according to the changes in the near-infrared signals of the cerebral cortex during and after treatment. The real-time change amplitude of the near-infrared in the target brain area is monitored, and the transcranial magnetic stimulation parameters are adjusted according to the real-time change amplitude.

[0023] Step S140: Stimulate the target brain area according to the transcranial magnetic stimulation parameters. By comparing the amplitude of the near-infrared signal in the target brain area with the data in the database, a corresponding transcranial magnetic stimulation scheme is selected. The stimulation pattern with the highest fit is selected for treatment, achieving adaptive adjustment of the stimulation scheme.

[0024] The above-mentioned transcranial magnetic stimulation intervention method, through transcranial magnetic stimulation of the target brain areas, including motor brain areas and non-motor brain areas, can intuitively show the changes in the target brain areas being intervened by monitoring the near-infrared change amplitude of the target brain areas, and can match the corresponding transcranial magnetic stimulation scheme according to the near-infrared change amplitude before and after stimulation to achieve the effect of stimulation feedback judgment.

[0025] In addition, real-time monitoring during transcranial magnetic stimulation treatment is achieved, and the stimulation plan can be adjusted in real time based on the monitoring information; functional near-infrared signals are continuously acquired during treatment, and the stimulation plan is continuously adjusted through real-time data matching and data analysis, achieving the goal of adaptive feedback individualized treatment.

[0026] In addition, a transcranial magnetic stimulation intervention device is also provided.

[0027] like Figure 3 As shown, in one embodiment, a transcranial magnetic stimulation intervention device includes an acquisition module 410, a control module 420, a transcranial magnetic stimulation module 430 and a near-infrared signal generating module 440, and the acquisition module 410, the transcranial magnetic stimulation module 430, and the near-infrared signal generating module 400 are electrically connected to the control module 420 respectively.

[0028] The acquisition module 410 is used to obtain the near-infrared change amplitude of the target brain area and the near-infrared change amplitude of the whole brain area before and after transcranial magnetic stimulation. The near-infrared signal generation module 440 is used to emit near-infrared signals. Specifically, the near-infrared signal generation module 440 and the acquisition module 410 are integrated into a functional near-infrared device. The functional near-infrared device is worn on the patient's head and can monitor the changes in near-infrared signals of the whole brain area and the target brain area. The functional near-infrared device has good resistance to electromagnetic interference and motion interference, and has a high degree of reliability in the sensitivity and specificity of responding to changes in neural excitability. It is an ideal tool for solving the problem of individualized stimulation of non-motor brain areas during transcranial magnetic stimulation.

[0029] The control module 420 is used to determine whether the near-infrared change amplitude of the target brain area exceeds a set threshold, and when it exceeds the set threshold, it is used to match the transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area. It is also used to monitor the real-time change amplitude of the near-infrared of the target brain area and adjust the transcranial magnetic stimulation parameters according to the real-time change amplitude. The transcranial magnetic stimulation intervention device includes an indicator light, which is connected to the control module. When the set threshold is exceeded, the indicator light is green, and when it is not exceeded, it is red. The control module 420 has a database, in which transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area are pre-stored. According to the pre-stored parameters, the transcranial magnetic stimulation device is driven to give the patient targeted treatment. The database is a local database or a cloud database, and corresponding data updates can be performed to facilitate timely updating and modification of the transcranial magnetic stimulation plan.

[0030] The transcranial magnetic stimulation module 430 is used to stimulate the target brain area according to the transcranial magnetic stimulation parameters. The transcranial magnetic stimulation module 430 is a transcranial magnetic therapy device.

[0031] The present invention uses transcranial magnetic stimulation, and the functional near-infrared device obtains the changes in near-infrared signals, thereby judging the excitability of cortical nerve activity during stimulation. By comparing with the data pre-stored in the database, the stimulation intensity is adjusted so that the treatment intensity of each patient reaches the individual optimal intensity, thereby improving the rehabilitation effect.

[0032] The above-described embodiments merely illustrate several implementations of the present invention, and while their descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, all of which fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A transcranial magnetic stimulation intervention device, characterized in that: include An acquisition module is used to obtain the near-infrared change amplitude of the target brain area before and after transcranial magnetic stimulation and the pre-stored transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area; a control module, configured to determine whether the near-infrared variation amplitude of the target brain area exceeds a set threshold, and when the set threshold is exceeded, to match the transcranial magnetic stimulation parameters corresponding to the near-infrared variation amplitude of the target brain area, and to monitor the near-infrared variation amplitude of the target brain area in real time, and to adjust the transcranial magnetic stimulation parameters according to the real-time variation amplitude; and a transcranial magnetic stimulation module, configured to perform transcranial magnetic stimulation on the target brain area according to the transcranial magnetic stimulation parameters; The acquisition module is also used to obtain the near-infrared change amplitude of the entire brain area before and after transcranial magnetic stimulation; The control module is further configured to compare the near-infrared variation amplitude of the target brain region with the near-infrared variation amplitude of the entire brain region as a reference to determine whether the near-infrared variation amplitude of the target brain region exceeds the set threshold; If the near-infrared variation amplitude of the target brain area does not exceed the set threshold, an alarm signal is issued and transcranial magnetic stimulation is enhanced.

2. The transcranial magnetic stimulation intervention device according to claim 1, characterized in that It also includes a near-infrared signal generating module, which is used to emit a near-infrared signal.

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