A mouse radiotherapy test device

Abstract

The application relates to the technical field of surgical test devices, and discloses a mouse radiotherapy test device which comprises a rotating seat, a sliding plate and a fixing table. The rotating seat comprises a base and a rotating ring, the rotating ring is rotatably installed on the base, the rotating ring is provided with a first sliding rail extending horizontally, and a first scale line is arranged on the surface of the base along the outer edge of the rotating ring. The sliding plate is installed on the first sliding rail and slides along the first sliding rail, a plurality of second scale lines are arranged on the sliding plate and are arranged at intervals along the first sliding rail. The fixing table is provided with a placing position for fixing a mouse, the fixing table is provided with a second sliding rail extending horizontally, the extending direction of the second sliding rail is perpendicular to the extending direction of the first sliding rail, the fixing table is installed on the sliding plate through the second sliding rail, the fixing table slides along the extending direction of the second sliding rail, a plurality of third scale lines are arranged on the fixing table and are arranged at intervals along the second sliding rail, and the angle and the horizontal position of the mouse on the placing position can be accurately adjusted at any time.

Description

Technical Field

[0001] This invention relates to the field of surgical testing equipment technology, and in particular to a mouse radiotherapy testing device. Background Technology

[0002] Currently, radiotherapy is the main treatment for head and neck tumors. However, the incidence of radiation-induced brain injury after radiotherapy is as high as 28.5%, which can cause obvious neuropsychiatric symptoms and even endanger the patient's life.

[0003] Mouse brain radiotherapy models are an important tool for studying the mechanisms of brain radiotherapy and novel treatment strategies. When using a medical linear accelerator X-knife to perform stereotactic radiotherapy on the mouse brain, it is necessary to firmly fix the mouse's head and to achieve precise rotation of the mouse at multiple angles to facilitate the physicist's radiotherapy plan design.

[0004] Existing stereotactic devices for mice only fix the head in a simple way, lacking the ability to rotate precisely and move accurately forward, backward, left, and right. This means that the placement of the stereotactic device needs to be changed frequently during each experiment, which affects the stability of the device. Summary of the Invention

[0005] The technical problem to be solved by the present invention is that existing mouse stereotactic devices cannot accurately rotate mice or move them accurately forward, backward, left, and right.

[0006] To address the aforementioned technical problems, this invention provides a mouse radiotherapy experimental device, comprising a rotating base, a sliding plate, and a fixed platform. The rotating base includes a base and a rotating ring, the rotating ring being rotatably mounted on the base. The rotating ring has a horizontally extending first slide rail, and the surface of the base has a ring of first graduation lines along the outer edge of the rotating ring. The sliding plate is mounted on the first slide rail and slides along the first slide rail. The sliding plate has multiple second graduation lines, which are spaced apart along the first slide rail. The fixed platform has a placement position for fixing the mouse, and the fixed platform has a horizontally extending second slide rail, the extension direction of which is perpendicular to the extension direction of the first slide rail. The fixed platform is mounted on the sliding plate via the second slide rail and slides along the extension direction of the second slide rail. The fixed platform has multiple third graduation lines, which are spaced apart along the second slide rail.

[0007] Furthermore, a pair of fixing mechanisms are provided on the fixing platform, and the placement position includes a head fixing position. The two fixing mechanisms are located on opposite sides of the head fixing position, and a clamp is provided on the side of the fixing mechanism facing the head fixing position.

[0008] Furthermore, each clamp has a sponge adhesive on the side facing the other clamp.

[0009] Furthermore, the placement position also includes a body fixing position, which is provided with a protective cover for blocking radiation, and the protective cover covers the body fixing position.

[0010] Furthermore, a pressure plate is provided between the protective cover and the fixed position of the body. One end of the pressure plate is hinged to the protective cover, and a bolt is screwed onto the protective cover. One end of the bolt passes through the protective cover and abuts against the surface of the pressure plate.

[0011] Furthermore, the protective cover is provided with a rubber band, one end of which is fixed to the protective cover, and the other end of which is sleeved on the side of the pressure plate facing away from the protective cover.

[0012] Furthermore, a third slide rail is provided on the fixing platform. The third slide rail is located on the side of the head fixing position away from the body fixing position, and the third slide rail extends in a direction away from the head fixing position. A slider is provided on the third slide rail, and the slider slides along the third slide rail. A clip for fixing the mouse head is provided on the slider.

[0013] Furthermore, the middle part of the base and the middle part of the slide plate are hollow structures, and the base is ring-shaped and the slide plate is frame-shaped.

[0014] Furthermore, the rotating ring is provided with a through hole, which horizontally penetrates the rotating ring. The through hole is the first slide rail, and the frame edge of the slide plate slidably passes through the through hole.

[0015] Furthermore, the fixed platform is provided with an elongated hollow hole, which serves as a second slide rail. A protrusion is fixed on the slide plate, which is embedded in the hollow hole. The fixed platform slides on the protrusion along the extension direction of the hollow hole.

[0016] Compared with the prior art, the mouse radiotherapy experimental device of this invention has the following advantages: by setting a rotatable rotating ring and a first and second sliding rail that are perpendicular to each other, the angle and horizontal position of the mouse in the placement position can be adjusted at any time to meet the needs of the physicist's radiotherapy plan design. In addition, the position of the mouse can be adjusted by directly fixing the base in the experiment without disassembling the base, thus improving the stability of the entire device. Attached Figure Description

[0017] Figure 1 This is a top view of one embodiment of the present invention;

[0018] Figure 2 This is a side view of one embodiment of the present invention;

[0019] Figure 3 This is a schematic diagram of the protective cover.

[0020] Figure 4 This is a structural diagram of a skateboard;

[0021] Figure 5 This is a schematic diagram of the rotating ring structure;

[0022] Figure 6 This is a structural diagram of the fixed platform.

[0023] In the diagram, 1. Rotating seat; 11. Base; 12. Rotating ring; 13. First scale line; 14. First slide rail; 141. Groove; 2. Slide plate; 21. Second scale line; 22. Protrusion; 3. Fixing platform; 31. Placement position; 32. Second slide rail; 33. Third scale line; 34. Fixing mechanism; 311. Head fixing position; 312. Body fixing position; 35. Protective cover; 351. Bolt; 352. Pressure plate; 353. Rubber band; 354. Crossbar; 36. Third slide rail; 37. Clamp. Detailed Implementation

[0024] The specific embodiments of the present invention will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and are not intended to limit the scope of the invention.

[0025] In the description of this invention, it should be understood that the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", etc., used to indicate the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0026] like Figure 1 As shown in the preferred embodiment of the present invention, a mouse radiotherapy test device includes a rotating seat 1, a sliding plate 2, and a fixed platform 3. The rotating seat 1 controls the rotation of the mouse to be tested, the sliding plate 2 controls the horizontal movement of the mouse to be tested, and the fixed platform 3 is used to fix the mouse to be tested.

[0027] like Figure 1 and Figure 6As shown, the rotating base 1 includes a base 11 and a rotating ring 12. The rotating ring 12 is rotatably mounted on the base 11. The rotating ring 12 is approximately circular, and the base 11 is also approximately circular. The base 11 is fitted over the rotating ring 12. The contact surface between the base 11 and the rotating ring 12 is a smooth arc surface. The operator can push the rotating ring 12 to rotate relative to the base 11. The surface of the base 11 has a first scale line 13 along the outer edge of the rotating ring 12. The first scale line 13 is an angle line. When the operator rotates the rotating ring 12, they can observe the first scale line 13 to know how many degrees the rotating ring 12 has rotated.

[0028] like Figure 1 and Figure 5 As shown, the rotating ring 12 is provided with a horizontally extending first slide rail 14, and the slide plate 2 is mounted on the first slide rail 14. An operator can push the slide plate 2 to slide along the first slide rail 14. The slide plate 2 is provided with multiple second scale lines 21, which are arranged at intervals along the first slide rail 14. The second scale lines 21 are located on the upper surface of the slide plate 2 and at its outer edge. When the operator pushes the slide plate 2 along the first slide rail 14, they can observe the second scale lines 21 to determine how far the slide plate 2 has moved relative to the rotating ring 12.

[0029] like Figure 1-4 As shown, the fixing platform 3 has a placement position 31 for fixing the mouse. The fixing platform 3 has a horizontally extending second slide rail 32, the extension direction of which is perpendicular to the extension direction of the first slide rail 14. The fixing platform 3 is mounted on the slide plate 2 via the second slide rail 32. The operator can push the fixing platform 3 to make the second slide rail 32 slide on the slide plate 2, and the sliding direction is the extension direction of the second slide rail 32. Since the second slide rail 32 is perpendicular to the first slide rail 14, a rectangular coordinate system can be established with the horizontal plane of the placement position 31, allowing the mouse fixed in the placement position 31 to move along the x and y axes. The fixing platform 3 has multiple third scale lines 33, which are arranged at intervals along the second slide rail 32. When the operator pushes the fixing platform 3 to slide, they can observe the third scale lines 33 to understand how far the fixing platform 3 has moved relative to the slide plate 2.

[0030] The working process of this invention is as follows: the base 11 is fixed on the X-knife experimental stage of a medical linear accelerator, the mouse is fixed on the fixed stage 3, the accurate position of the mouse for the experiment is calculated according to actual needs, the rotating ring 12 is rotated along the first scale line 13 to adjust the angle of the fixed stage 3 so that the mouse reaches the target angle, and then the sliding plate 2 and the fixed stage 3 are pushed, the fixed stage 3 is translated to the target position, so that the mouse reaches the accurate position where the experiment can be performed. In summary, the embodiments of this invention provide a mouse radiotherapy experimental device. By setting a rotatable rotating ring 12 and mutually perpendicular first slide rail 14 and second slide rail 32, the angle and horizontal position of the mouse on the placement position 31 can be accurately adjusted at any time, meeting the needs of the physicist's radiotherapy planning design. Moreover, in the experiment, the position of the mouse can be adjusted by directly fixing the base 11 without disassembling the base 11, improving the stability of the entire device.

[0031] like Figure 1-4 As shown, the fixing platform 3 is equipped with a pair of fixing mechanisms 34. The placement position 31 includes a head fixing position 311 and a body fixing position 312. The head fixing position 311 is used to place the head of the mouse to be tested, and the body fixing position 312 is used to place the body of the mouse to be tested. The two fixing mechanisms 34 are located on opposite sides of the head fixing position 311. Each fixing mechanism 34 has a clamp 341 on the side facing the head fixing position 311. After the mouse's head is placed in the head fixing position 311, the two clamps 341 can be used to clamp the sides of the mouse's head, thereby fixing the mouse's head and preventing it from moving around during the experiment. Each clamp 341 has a sponge adhesive on the side facing the other clamp 341, which makes the mouse's head more comfortable and secure when clamped.

[0032] like Figure 1-6As shown, the body fixation position 312 is provided with a protective cover 35 for blocking radiation. The protective cover 35 covers the body fixation position 312. The protective cover 35 is a lead glass cover, so that the body of the mouse can be protected and the body of the mouse can be fixed when the mouse undergoes head radiotherapy. A pressure plate 352 is provided between the protective cover 35 and the body fixing position 312. A horizontal bar 354 is provided on the protective cover 35, extending horizontally. One end of the pressure plate 352 is hinged to the protective cover 35 via the horizontal bar 354. The pressure plate 352 can rotate downwards around the horizontal bar 354. A bolt 351 is screwed onto the top of the protective cover 35. One end of the bolt 351 passes through the protective cover 35 and abuts against the surface of the pressure plate 352. Operators can rotate the bolt 351 to extend it downwards, with the bottom end of the bolt pressing against the surface of the pressure plate 352, thus allowing the pressure plate 352 to rotate downwards. After the mouse's body is placed into the body fixing position 312, rotating the bolt 351 will cause the pressure plate 352 to press down on the mouse's body, thus fixing it in place. The protective cover 35 is provided with a rubber band 353. One end of the rubber band 353 is fixed to the protective cover 35, and the other end of the rubber band 353 is sleeved on the side of the pressure plate 352 facing away from the protective cover 35. The rubber band 353 is used to apply elastic force to the pressure plate 352, so that the pressure plate 352 is tightly attached to the bottom end of the bolt 351. When the bolt 351 is rotated and moves upward, the pressure plate 352 can flip upward with the bolt 351. Both the bolt 351 and the pressure plate 352 are made of ABS plastic.

[0033] like Figure 1 , Figure 2 and Figure 6 As shown, the fixing platform 3 is provided with a third slide rail 36. The third slide rail 36 is located on the side of the head fixing position 311 away from the body fixing position 312, and the third slide rail 36 extends in a direction away from the head fixing position 311. The third slide rail 36 is provided with a slider, which slides along the third slide rail 36. The slider is provided with a clip 37 for fixing the mouse head. In actual operation, the slider can be slid according to the size of the mouse to be tested, and the distance between the slider and the head fixing position 311 can be adjusted to ensure that the clip 37 can clamp the scalp of the mouse.

[0034] like Figure 1-4As shown, the middle parts of the base 11 and the middle parts of the slide plate 2 are hollow structures, which facilitates the radiation energy passing through the base 11 and the slide plate 2 during mouse radiotherapy. The base 11 is annular, and the slide plate 2 is frame-shaped. The rotating ring 12 has a through hole that horizontally penetrates the rotating ring 12. The through hole is the first slide rail 14, and the frame edge of the slide plate 2 slidably passes through the through hole. In addition to restricting the sliding direction of the slide plate 2, the through hole can also prevent the slide plate 2 from falling off the rotating ring 12. The rotating ring 12 includes a circular bottom ring and a connecting block. The bottom ring has four grooves 141 for placing the frame of the slide plate 2. The connecting block is fixed in the grooves 141, and the connecting block and the grooves 141 form the through hole. The fixed platform 3 is provided with an elongated hollow hole, which serves as a second slide rail 32. A protrusion 22 is fixed on the slide plate 2, and the protrusion 22 is embedded in the hollow hole. The fixed platform 3 slides on the protrusion 22 along the extension direction of the hollow hole. The sliding range of the fixed platform 3 is the length range of the hollow hole. The protrusion 22 can prevent the fixed platform 3 from detaching from the slide plate 2.

[0035] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and substitutions can be made without departing from the technical principles of the present invention, and these improvements and substitutions should also be considered within the scope of protection of the present invention.

Claims

1. A mouse radiotherapy experimental device, characterized in that, include: A rotating base, comprising a base and a rotating ring, wherein the rotating ring is rotatably mounted on the base, the rotating ring is provided with a horizontally extending first slide rail, and the surface of the base is provided with a first scale line along the outer edge of the rotating ring; A skateboard, wherein the skateboard is mounted on a first slide rail and slides along the first slide rail, and the skateboard has multiple second scale lines arranged at intervals along the first slide rail; and A fixing platform is provided with a placement position for fixing a mouse. The fixing platform is provided with a horizontally extending second slide rail. The extension direction of the second slide rail is perpendicular to the extension direction of the first slide rail. The fixing platform is mounted on the slide plate via the second slide rail. The fixing platform slides along the extension direction of the second slide rail. The fixing platform is provided with multiple third scale lines, which are arranged at intervals along the second slide rail. The fixing platform is provided with a pair of fixing mechanisms. The placement position includes a head fixing position. The two fixing mechanisms are located on opposite sides of the head fixing position. The fixing mechanism is provided with a clamp on the side facing the head fixing position. The placement position also includes a body fixing position, which is provided with a protective cover for blocking radiation, and the protective cover covers the body fixing position; The fixing platform is provided with a third slide rail, which is located on the side of the head fixing position away from the body fixing position and extends away from the head fixing position. The third slide rail is provided with a slider, which slides along the third slide rail, and the slider is provided with a clip for fixing the mouse head.

2. The mouse radiotherapy experimental device according to claim 1, characterized in that: Each clamp has a sponge adhesive on the side facing the other clamp.

3. The mouse radiotherapy experimental device according to claim 1, characterized in that: A pressure plate is provided between the protective cover and the fixed position of the body. One end of the pressure plate is hinged to the protective cover. A bolt is screwed onto the protective cover. One end of the bolt passes through the protective cover and abuts against the surface of the pressure plate.

4. The mouse radiotherapy experimental device according to claim 3, characterized in that: The protective cover is provided with a rubber band, one end of which is fixed to the protective cover, and the other end of which is sleeved on the side of the pressure plate facing away from the protective cover.

5. The mouse radiotherapy experimental device according to claim 1, characterized in that: The middle part of the base and the middle part of the slide plate are hollow structures, and the base is ring-shaped and the slide plate is frame-shaped.

6. The mouse radiotherapy experimental device according to claim 5, characterized in that: The rotating ring is provided with a through hole, which horizontally penetrates the rotating ring. The through hole is the first slide rail, and the frame edge of the sliding plate slidably passes through the through hole.

7. The mouse radiotherapy experimental device according to claim 1, characterized in that: The fixed platform is provided with a long, narrow hollow hole, which serves as a second slide rail. A protrusion is fixed on the slide plate, and the protrusion is embedded in the hollow hole. The fixed platform slides on the protrusion along the extension direction of the hollow hole.

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