Topical compositions

Abstract

The present invention relates to a compound comprising phytantriol and C 4‑6 Topical compositions of mixtures of alkylglycerols, and use of said mixtures for reducing and / or preventing the growth of microorganisms.

Description

[0001] The present invention relates to a compound comprising phytantriol and C 4-6 Topical compositions of mixtures of alkylglycerols, and use of said mixtures for reducing and / or preventing the growth of microorganisms.

[0002] Microorganisms can cause the decay of food and daily consumer products (such as cosmetic compositions, household items, plastics, paper or paints). Therefore, reducing microbial growth is crucial for improving the shelf life (storage stability) of the product itself while also ensuring the safety of consumers. Therefore, preservatives are usually added to the corresponding products. However, since the use of certain preservatives is subject to intense public discussion, the option of being able to reduce or even avoid such agents is a strong desire in the industry. Since cosmetics are particularly susceptible to attack by microorganisms, there is a continuous need for alternatives to help cosmetic formulas remain safe and prevent changes in time.

[0003] Therefore, the problem to be solved by the present invention is to provide a new, safe and effective way to reduce or inhibit microbial growth.

[0004] Surprisingly, it has now been discovered that phytantriol and C 4-6 Combinations of alkylglycerols show a synergistic antimicrobial effect. This surprising discovery is very advantageous because it can be used to improve product stability and shelf life by protecting cosmetic compositions, household products, plastics, paper and / or paints from fungi (e.g., yeasts and molds) and bacteria. However, it can also be used to reduce or avoid the amount of preservatives in cosmetic compositions by maintaining the antimicrobial properties.

[0005] Therefore, in a first embodiment, the present invention relates to a polyol comprising phytantriol and C 4-6 Topical compositions of alkylglycerols.

[0006] In a second embodiment, the present invention relates to phytantriol and C 4-6 Use of mixtures of alkylglycerols as synergistic antimicrobial mixtures (preservative synergists).

[0007] In a third embodiment, the present invention relates to phytantriol and C 4-6 Use of mixtures of alkylglycerols as antimicrobial agents (ie agents exhibiting antimicrobial activity).

[0008] Specifically, the present invention relates to phytantriol and C 4-6The invention relates to the use of a mixture of alkylglycerols as an antifungal and / or antibacterial agent, more particularly as an agent for killing and / or inhibiting the growth of fungi, such as yeasts or molds and / or bacteria (Gram-positive and / or Gram-negative), most preferably Escherichia Coli (E. Coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus), Aspergillus brasiliensis (A. brasiliensis) and / or Candida albicans (C. albicans) and mixtures thereof.

[0009] In another embodiment, the present invention relates to a method for killing and / or inhibiting the growth of microbial cells, in particular fungi (e.g., yeast and / or mold) and / or bacterial cells, most particularly Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus brasiliensis and / or Candida albicans and mixtures thereof, the method comprising treating the microbial cells with phytantriol and C 4-6 A mixture of alkyl glycerols is contacted.

[0010] Phytantriol [CAS: 74563-64-7] is a colorless to pale yellow viscous liquid with the chemical name 3,7,11,15-tetramethyl-hexadecane-1,2,3-triol. Phytantriol is commercially available, for example, from DSM Nutritional Products Ltd, Kaiseraugst.

[0011] Terminology C 4-6 Alkylglycerol refers to straight-chain and cyclic C 4-6 Alkylglycerols, such as butylglycerol [CAS 624-52-2], pentylglycerol [CAS 22636-32-4], hexylglycerol [CAS 10305-38-1], cyclobutylglycerol, cyclopentylglycerol and cyclohexylglycerol [CAS: 10305-41-6], hexylglycerol (also known as 3-(hexyloxy)-1,2-propanediol) and cyclohexylglycerol (also known as 3-(cyclohexyloxy)-1,2-propanediol) are particularly preferred. In all embodiments of the present invention, the most preferred C 4-6 Alkylglycerol is hexylglycerol. This C 4-6 Alkylglycerols are commercially available, for example, from Adeka Corporation, Japan.

[0012] The term "antimicrobial activity" (or "antimicrobial effect") as used herein refers to the ability to kill and / or inhibit the growth of microbial cells, such as, in particular, bacteria and fungal cells (in particular, molds and / or yeasts), such as Propionibacterium acnes (P. acnes), Staphylococcus epidermidis (S. epidermis), Malassezia furfur (M. furfur), Aspergillus braziliensis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus braziliensis and / or Candida albicans and mixtures thereof, however preferably Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus braziliensis and / or Candida albicans and mixtures thereof.

[0013] In all embodiments of the present invention, topical composition preferably comprises the phytantriol of at least 0.005 % by weight in amount.More preferably, the amount of phytantriol is selected from the scope of about 0.01 % by weight to 5 % by weight, more preferably the scope of about 0.05 % by weight to 3 % by weight, and most preferably the scope of 0.1 % by weight to 2 % by weight.Further suitable scope comprises 0.1 % by weight to 1.5 % by weight or 0.1 % by weight to 1 % by weight based on the gross weight of composition.

[0014] In all embodiments of the present invention, the topical composition preferably comprises C 4-6 Alkylglycerol, the C 4-6 The amount (total amount) of alkyl glycerol is selected from the range of about 0.01 wt % to about 5 wt %, preferably 0.1 wt % to 4 wt %, most preferably 0.25 wt % to 3 wt %, based on the total weight of the composition. Further suitable ranges include 0.25 wt % to 2 wt % and 0.3 wt % to 1 wt %.

[0015] In all embodiments of the present invention, C 4-6 The weight ratio (w / w) of alkylglycerol to phytantriol is preferably selected from the range of 5:1 to 1:5, such as in the range of 2.5:1 to 1:2.5, most preferably in the range of 1.5:1 to 1:1. Most preferably, in all embodiments of the present invention, C 4-6 The alkylglycerol is used in excess, i.e. in an amount higher than the amount of phytantriol, for example in a weight ratio greater than 1, more preferably in a weight ratio of at least 1.25 (i.e. 1.25 parts of C 4-6 alkylglycerol to 1 part phytantriol).

[0016] In order to utilize phytantriol and C 4-6 The synergistic antimicrobial activity of the mixture of alkylglycerols allows the mixture to be used in a variety of formulations or applications, such as cosmetic or pharmaceutical compositions, medical products or household products.

[0017] In one aspect, the use according to the invention may be a technological use, for example to reduce or prevent microbial growth in a topical composition, for example to increase shelf life and / or storage stability.

[0018] On the other hand, phytantriol and C 4-6 The use according to the invention of the mixture of alkylglycerols can be carried out in a cosmetic or pharmaceutical sense. For example, in the case of specific antimicrobial therapies, pharmaceutical applications are conceivable. Cosmetic applications are conceivable, for example for maintaining a healthy skin homeostasis and / or for balancing the skin microbiome.

[0019] Phytantriol and C 4-6 Without being bound by theory, mixtures of alkylglycerols (or topical compositions according to the invention comprising said mixtures) may also be used to treat and / or prevent pathological skin conditions, such as dermatitis and / or acne, by maintaining a healthy skin homeostasis and / or by balancing the skin microbiota, e.g. by avoiding the (over)growth of pathological microorganisms.

[0020] In all embodiments of the invention, the methods and uses according to the invention are preferably technical and / or cosmetic (non-therapeutic), most preferably technical (ie for preservative purposes).

[0021] However, the present invention also relates in another aspect to a topical composition according to the invention for treating and / or preventing pathological skin conditions, such as dermatitis and / or acne, by maintaining a healthy skin homeostasis and / or by balancing the skin microbiome, the method preferably comprising the step of contacting the skin and / or scalp with the topical composition.

[0022] The topical composition according to the invention is preferably a cosmetic or pharmaceutical composition for topical application to mammalian keratinous tissue, such as in particular to human skin or human scalp and hair.

[0023] As used in this application, the term "cosmetic composition" refers to Cosmetic compositions as defined under the heading "Kosmetika" in Lexikon Chemie, 10th edition, 1997, Georg Thieme Verlag Stuttgart, New York, and as disclosed in A. Domsch, "Cosmetic Compositions", Verlag für chemische Industrie (ed. H. Ziolkowsky), 4th edition, 1992.

[0024] The cosmetic or pharmaceutical composition according to the invention preferably further comprises a physiologically acceptable medium, ie a medium that is compatible with keratinous materials such as the skin, mucous membranes and keratin fibers. Preferably, the physiologically acceptable medium is a cosmetically acceptable or pharmaceutically acceptable carrier.

[0025] The term cosmetically or pharmaceutically acceptable carrier is taken to mean all carriers and / or excipients and / or diluents customarily used in cosmetic compositions, such as in particular oils (cosmetic oils), water, surfactants, emulsifiers, thickeners.

[0026] The topical compositions according to the present invention are generally prepared by mixing phytantriol and C 4-6 Alkyl glycerol is prepared by mixing with a suitable carrier.

[0027] The exact amount of carrier will depend on the amount of phytantriol and C 4-6 The actual level of alkylglycerol and any other optional ingredients (eg, other active ingredients) that one of ordinary skill in the art would classify as distinct from the carrier.

[0028] In an advantageous embodiment, the cosmetic or pharmaceutical composition according to the invention comprises from about 50% to about 99%, preferably from about 60% to about 98%, more preferably from about 70% to about 98%, such as in particular from about 80% to about 95% of a carrier, based on the total weight of the cosmetic composition.

[0029] In a particularly advantageous embodiment, the carrier also consists of at least 40 wt. %, more preferably at least 50 wt. %, most preferably at least 55 wt. % water, such as in particular about 55 wt. % to about 90 wt. % water.

[0030] The compositions of the present invention (including carriers) may contain conventional adjuvants and additives, such as preservatives / antioxidants, fatty substances / oils, organic solvents, silicones, thickeners, emollients, emulsifiers, antifoaming agents, aesthetic components such as fragrances, surfactants, fillers, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidulants or alkalizing agents, dyes, colorants / dyes, abrasives, absorbents, chelating and / or sequestering agents, essential oils, skin sensates, astringents, pigments, or any other ingredient usually formulated into such compositions.

[0031] According to the invention, the composition according to the invention may also contain other cosmetic active ingredients conventionally used in cosmetic or pharmaceutical compositions. Exemplary active ingredients include skin lightening agents; UV filters, agents for treating hyperpigmentation; agents for preventing or reducing inflammation; firming agents, moisturizing agents, soothing agents and / or energizing agents, and agents for improving elasticity and the skin barrier.

[0032] Examples of cosmetic excipients, diluents, adjuvants, additives and active ingredients commonly used in the skin care industry suitable for use in the cosmetic composition of the present invention are described, for example, in the International Cosmetic Ingredient Dictionary & Handbook by Personal Care (http: / / www.personalcarecouncil.org / ) provided by the Personal Care Products Council, which can be accessed through the online INFO BASE (http: / / online.personalcarecouncil.org / jsp / Home.jsp), but are not limited thereto.

[0033] The necessary amounts of the active ingredients and excipients, diluents, adjuvants, additives, etc. can be readily determined by a skilled person based on the desired product form and application. Additional ingredients can be added to the oil phase, the aqueous phase, or separately as appropriate.

[0034] In some cases, the cosmetically active ingredients useful herein may provide more than one benefit or operate via more than one mode of action.

[0035] Of course, the person skilled in the art will take care to choose the above-mentioned optional additional ingredients, adjuvants, diluents and additives and / or their amounts so that the advantageous properties essentially associated with the combination according to the invention are not or are not substantially adversely affected by one or more of the envisaged additions.

[0036] Preferably, the cosmetic or pharmaceutical composition according to the invention is in the form of a suspension or dispersion in a solvent or a fatty substance, or alternatively in the form of an emulsion or microemulsion (in particular O / W type or W / O type), a PIT emulsion, a nanoemulsion, a multiple emulsion (for example O / W / O type or W / O / W type), a Pickering emulsion, a hydrogel, a lipid gel, a single-phase or multiphase solution or a vesicular dispersion.

[0037] The cosmetic or pharmaceutical composition according to the present invention may be in the form of a liquid, a lotion, a thickened lotion, a gel, a cream, an emulsion, an ointment or a paste.

[0038] The pH of the cosmetic or pharmaceutical composition according to the present invention is in the range of 3 to 10, preferably in the range of 3 to 8, most preferably in the range of 3 to 7.5. The pH is adjusted by methods known to those skilled in the art, for example by using an acid (e.g., a hydroxy acid, including glycolic acid, lactic acid, malic acid, citric acid and tartaric acid) or a base (e.g., sodium hydroxide or potassium hydroxide or ammonium hydroxide and mixtures thereof).

[0039] Preferably, in the composition according to the invention, the acid, if present, is used in an amount of at least 0.0001 wt.-%, for example in an amount of 0.01 to 1 wt.-%, in particular in an amount of 0.01 to 0.5 wt.-%.

[0040] The cosmetic composition according to the invention advantageously comprises an additional preservative or preservative synergist. In all embodiments of the invention, particularly suitable preservatives or preservative synergists are benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, dehydroacetic acid, caprylhydroxamic acid, alcohol, denatured alcohol, hydroxyacetophenone, caprylyl glycol, pentylene glycol, 1,2-hexanediol, decanediol, monoglycerides such as glyceryl laurate, propylene glycol caprylate, propylene glycol heptanoate and mixtures thereof. Preservatives and / or preservative synergists, when present, are preferably used in an amount of 0.01% to 2% by weight, more preferably in an amount of 0.05% to 1.5% by weight, and most preferably in an amount of 0.1% to 1.0% by weight, based on the total weight of the composition.

[0041] Furthermore, it is preferred that the topical composition according to the invention does not contain any parabens, benzethonium chloride, piroctone olamine, lauroyl arginine, methylisothiazolinone, chloromethylisothiazolinone, bronopol, benzalkonium chloride, formaldehyde-releasing compounds, salicylic acid, triclosan, DMDM ​​hydantoin, chlorphenesin and IPBC (iodopropynyl butylcarbamate).

[0042] The cosmetic composition according to the invention is in particular a skin care preparation, a functional preparation and / or a hair care preparation, such as most in particular a skin care preparation or a hair care preparation.

[0043] Examples of skin care preparations are, in particular, photoprotective preparations (sunscreen preparations), anti-aging preparations, preparations for the treatment of photoaging, body oils, body milks, body gels, care creams, skin ointments, moisturizing preparations (for example moisturizing gels or moisturizing sprays), face and / or body moisturizers, and skin-lightening preparations.

[0044] Examples of functional preparations are cosmetic compositions containing active ingredients, such as, but not limited to, hormone preparations, vitamin preparations, plant extract preparations, anti-aging preparations, and / or antimicrobial (antibacterial or antifungal) preparations.

[0045] Examples of hair care products that are suitable according to the invention and that may be mentioned are shampoos, conditioners (also called hair serums), hair styling compositions, hair tonics, hair rejuvenating compositions, hair washes, water waving washes, hair sprays, hair creams, hair gels, hair oils, hair pomades or hair brilliantines. These products are therefore always products that are applied to the hair and scalp for a shorter or longer period of time, depending on the actual purpose of their use.

[0046] If the hair care products according to the invention are supplied as shampoos, these can be clear liquids, opaque liquids (with pearlescent effect), in cream form, gel-like or powdery form or tablet form, and in aerosol form. The surfactant raw materials on which these shampoos are based can be anionic, cationic, nonionic and amphoteric in nature, and can also be present as combinations of these substances.

[0047] Examples of anionic surfactants suitable for incorporation into shampoo preparations according to the present invention are C 10-20 Alkyl and alkylene carboxylates, alkyl ether carboxylates, fatty alcohol sulfates, fatty alcohol ether sulfates, alkanolamide sulfates and sulfonates, fatty acid alkanolamide polyglycol ether sulfates, alkanesulfonates and hydroxyalkanesulfonates, olefinsulfonates, acyl esters of isothiocyanates, α-sulfo fatty acid esters, alkylbenzenesulfonates, alkylphenol glycol ether sulfonates, sulfosuccinates, sulfosuccinic acid monoesters and diesters, fatty alcohol ether phosphates, protein-fatty acid condensation products, alkyl monoglycerol sulfates and sulfonates, alkyl glycerol ether sulfonates, fatty acid methyltaurates, fatty acid sarcosinates, and sulforicinoleates. These compounds and mixtures thereof are used in the form of their salts which are soluble or dispersible in water, for example, sodium, potassium, magnesium, ammonium, monoethanolammonium, diethanolammonium and triethanolammonium salts and similar alkylammonium salts.

[0048] Examples of suitable cationic surfactants are quaternary ammonium salts, such as di(C 10 -C 24 Alkyl) dimethylammonium chloride or ammonium bromide, preferably di(C 12 -C 18 Alkyl)-dimethylammonium chloride or ammonium bromide; C 10 -C 24 -Alkyl dimethyl ethyl ammonium chloride or ammonium bromide; C 10 -C 24 - alkyltrimethylammonium chloride or bromide, preferably hexadecyltrimethylammonium chloride or bromide, and C 20 -C 24 -Alkyltrimethylammonium chloride or bromide; C 10 -C24 4-Alkyldimethylbenzyl ammonium chloride or bromide, preferably C 12 -C 18 -Alkyl dimethyl benzyl ammonium chloride; N-(C 12 -C 18 -alkyl) pyridinium chloride or pyridinium bromide, preferably N-(C 12 -C 16 -alkyl) pyridinium chloride or pyridinium bromide; N-(C 12 -C 18 -alkyl)isoquinolinium chloride, bromide or monoalkyl sulfate; N-(C 12 -C 18 -alkylacylcarbamoylmethyl)pyridinium chloride; N-(C 12 -C 18 -alkyl)-N-methylmorpholinium chloride, bromide or monoalkyl sulfate; N-(C 12 -C 18 -alkyl)-N-ethylmorpholinium chloride, bromide or monoalkyl sulfate; C 16 -C 18 -Alkyl pentaoxyethyl ammonium chloride; isobutylphenoxyethoxyethyl dimethyl-benzylammonium chloride; salts of N,N-diethylaminoethyl stearamide and oleamide with hydrochloric acid, acetic acid, lactic acid, citric acid, and phosphoric acid; N-acylaminoethyl-N,N-diethyl-N-methylammonium chloride, ammonium bromide or monoalkylammonium sulfate and N-acylaminoethyl-N,N-diethyl-N-benzylammonium chloride, ammonium bromide or monoalkylammonium sulfate, wherein the acyl group is preferably stearyl or oleyl.

[0049] Examples of suitable nonionic surfactants which can be used as detergent materials are fatty alcohol ethoxylates (alkyl polyethylene glycols); alkylphenol polyethylene glycols; alkylthiol polyethylene glycols; fatty amine ethoxylates (alkylamino polyethylene glycols); fatty acid ethoxylates (acyl polyethylene glycols); polypropylene glycol ethoxylates (Pluronic); fatty acid alkanolamides (fatty acid amide polyethylene glycols); sucrose esters; sorbitan esters and polyethylene glycol ethers.

[0050] Examples of amphoteric surfactants that can be added to shampoos are N-(C 12 -C 18 -alkyl)-β-aminopropionate and N-(C 12 -C 18 -alkyl)-β-iminodipropionate as alkali metal salts and mono-, di- and tri-alkylammonium salts; N-acylamidoalkyl-N,N-dimethylacetylbetaine, preferably N-(C8-C 18 -Acyl)amidopropyl-N,N-dimethylacetyl betaine; C 12 -C18 Alkyl dimethyl sulfonyl betaine; amphoteric surfactant based on imidazoline (trade name: ), preferably 1-(β-carboxymethoxyethyl)-1-(carboxymethyl)-2-laurylimidazoline sodium salt; amine oxide, such as C 12 -C 18 -Alkyl dimethyl amine oxide, fatty acid amide alkyl dimethyl amine oxide.

[0051] The hair care preparations according to the invention may additionally contain other additives customary in hair care, such as perfumes, colorants, also those additives which simultaneously carry out dyeing or coloring of the hair, solvents, opacifiers and pearlescent agents (for example esters of fatty acids with polyols, magnesium and zinc salts of fatty acids), dispersions based on copolymers, thickeners (for example sodium chloride, potassium chloride and ammonium chloride), sodium sulfate, fatty acid alkanolamides, cellulose derivatives, natural rubber, also plant extracts, protein derivatives (for example gelatin), collagen hydrolysates, polypeptides with a natural or synthetic basis, egg yolk, lecithin, lanolin and lanolin derivatives, fats, oils, fatty alcohols, silicones, deodorants, substances with antimicrobial activity, substances with antiseborrheic activity, substances with keratolytic and keratolytic effects (for example sulfuric acid, salicylic acid and enzymes), and other antidandruff agents (for example ethanolamine, climbazole, zinc pyrithione, pyrithion), ketoconazole, salicylic acid, sulfur, tar preparations, derivatives of undecylenic acid), extracts of nettle, rosemary, poplar, birch, walnut, willow bark and / or arnica.

[0052] The topical cosmetic composition according to the invention is advantageously an O / W emulsion, a W / O emulsion, and / or a gel such as a shower gel.

[0053] Furthermore, the topical composition in the form of an O / W emulsion, W / O emulsion and / or gel according to the invention is a skin care preparation intended for the treatment of acne or for maintaining healthy skin homeostasis and / or for maintaining the balance of the skin microbiota.

[0054] The O / W emulsion according to the present invention advantageously comprises (i) phytantriol in an amount selected from the range of about 0.01% to 2% by weight, preferably from 0.05% to 1.5% by weight, most preferably from 0.1% to 1% by weight, based on the total weight of the composition; (ii) C 4-6 Alkylglycerol, the C 4-6The amount of alkylglycerol is selected from the range of about 0.01 wt.% to 2 wt.%, preferably 0.1 wt.% to 1.5 wt.%, most preferably 0.1 wt.% to 1 wt.%, based on the total weight of the composition; (iii) water; and (iv) at least one O / W emulsifier or Si / W emulsifier selected from the following list: glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglucose distearate, ceteareth-20, steareth-2, steareth-12, PEG-40 stearate, phosphate esters, and their salts, such as cetyl phosphate ( A), diethanolamine cetyl phosphate ( DEA), potassium cetyl phosphate ( K), sodium cetearyl sulfate, sodium glyceryl oleate phosphate, hydrogenated vegetable glyceride phosphate, sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, dodecyl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate and hydrated polyisobutene, and mixtures thereof. In addition, one or more synthetic polymers can be used as emulsifiers, such as PVP eicosene copolymer, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates / steareth-20 methacrylate copolymer, PEG-22 / dodecyl glycol copolymer, PEG-45 / dodecyl glycol copolymer, and mixtures thereof. In a specific preferred embodiment, the O / W emulsifier is selected from the group consisting of: cetyl phosphate (e.g., in particular potassium cetyl phosphate (as K commercially available)), glyceryl stearate (and) PEG-100 stearate (as 165 is commercially available) and / or polyalkylene glycol ethers (for example, in particular laureth-35 (lauryl alcohol with 35 EO units; as 35 is commercially available). The at least one O / W emulsifier is preferably used in an amount of about 0.001% to 10% by weight, more preferably 0.1% to 7% by weight, relative to the total weight of the composition. In addition, the cosmetic composition in the form of an O / W emulsion advantageously contains at least one auxiliary emulsifier selected from the following list: alkyl alcohols, such as, but not limited to, cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol ( O), stearyl alcohol ( 18) Behenyl alcohol 22), Glyceryl Monostearate, Glyceryl Myristate ( 3650), hydrogenated coconut acid glyceride (Lipocire Na10), and mixtures thereof.

[0055] The W / O emulsion according to the present invention advantageously comprises (i) phytantriol in an amount selected from the range of 0.01 wt % to 2 wt %, preferably 0.05 wt % to 1.5 wt %, most preferably 0.1 wt % to 1 wt %, based on the total weight of the composition; (ii) C 4-6 Alkylglycerol, the C 4-6 The amount of alkylglycerol is selected from the range of about 0.01 wt% to 2 wt%, preferably 0.1 wt% to 1.5 wt%, most preferably 0.1 wt% to 1 wt%, based on the total weight of the composition; (iii) water; and (iv) at least one W / O emulsifier or W / Si emulsifier selected from the following list: polyglyceryl-2-dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, cetyl dimethicone copolyol, polyglyceryl-3 diisostearate polyglyceryl oleate / isostearate, polyglyceryl-6 hexaricinolate, polyglyceryl-4-oleate, polyglyceryl-4-oleate / PEG-8 propylene glycol cocoate, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallowate, potassium ricinoleate. The at least one W / O emulsifier is preferably used in an amount of about 0.001 wt % to 10 wt %, more preferably 0.2 wt % to 7 wt %, relative to the total weight of the composition.

[0056] The gel preparation according to the present invention advantageously comprises (i) phytantriol in an amount selected from the range of 0.01 wt % to 2 wt %, preferably 0.05 wt % to 1.5 wt %, most preferably 0.1 wt % to 1 wt % based on the total weight of the composition; (ii) C 4-6 Alkylglycerol, the C 4-6The amount of alkylglycerol is selected from the range of about 0.01 wt % to 2 wt %, preferably 0.1 wt % to 1.5 wt %, most preferably 0.1 wt % to 1 wt % based on the total weight of the composition; (iii) water; and (iv) at least one water-soluble thickener. Such water-soluble thickeners are well known to those skilled in the art and are listed, for example, in Robert L. Davidson's "Handbook of Water soluble gums and resins" (Mc Graw Hill Book Company (1980)). Particularly suitable water-soluble thickeners are selected from the group consisting of: polyacrylic acids (for example, those sold under the trade names Carbomer or Commercially available), 2-acrylamido-2-methylpropanesulfonic acid homopolymer (e.g. as 11-80 commercially available), acrylate copolymers (e.g., under the trade name or 33), branched poly(methacryloyloxyethyltrimethylammonium chloride) (INCI name Polyquaternium-37), unmodified guar gum (commercially available, for example, under the trade name Jaguar), starch or its derivatives and / or hydroxyalkylcellulose. Preferably, the water-soluble thickener is used in an amount of about 0.001% to 10% by weight, more preferably 0.2% to 7% by weight, based on the total weight of the composition.

[0057] It has been observed that when phytantriol and C 4-6 In other words, by adding the synergistic antimicrobial mixture to the composition, an increase in antimicrobial activity was observed compared to not using phytantriol or not using C 4-6 When alkylglycerol is used (i.e., using either phytantriol or C 4-6 Compared with alkyl glycerol, the number of microorganisms that grew was less. 4-6 The antimicrobial effect of alkylglycerols has a synergistic effect, especially in cosmetic compositions against C 4-6 The antimicrobial effect of alkylglycerols is synergistic.

[0058] This is also very advantageous because, accordingly, C 4-6 The amount of alkylglycerols while maintaining the same antimicrobial effect.

[0059] It has further been observed that the antimicrobial effect is particularly pronounced in aqueous systems. This is very advantageous since it is well known that the aqueous phase of a product is usually the most susceptible to microbial growth.

[0060] In another aspect, the present invention relates to a method for inhibiting or delaying microbial decomposition of a cosmetic composition, household product, plastic, paper and / or paint, wherein the method comprises adding phytantriol and C 4-6 The step of preparing a mixture of alkyl glycerols, the phytantriol and C 4-6 The amount of alkyl glycerol is

[0061] (i) 0.01 to 2 wt %, preferably 0.05 to 1.5 wt %, most preferably 0.1 to 1 wt % of phytantriol, based on the total weight of the composition, and

[0062] (ii) 0.01 wt % to 2 wt %, preferably 0.1 wt % to 1.5 wt %, or 0.1 wt % to 1 wt % of C based on the total weight of the composition 4-6 Alkyl glycerol.

[0063] The following examples are provided to further illustrate the compositions and effects of the present invention. These examples are merely illustrative and are not intended to limit the scope of the present invention in any way. Example

[0064] The evaluation of the preservation of the cosmetic formulations was based on inoculation of the formulations as outlined in Table 1 with a calibrated inoculum (prepared from the relevant microbial strains). Therefore, 0.2 ml of the calibrated inoculum was added to each formulation to obtain a concentration of between 1×10 4 cfu / ml and 1×10 7 cfu / ml or between 1×10 4 cfu / g and 1×10 7 cfu / g, and between 1×10 2 cfu / ml and 1×10 6 cfu / ml or between 1×10 2 cfu / g and 1×10 6 cfu / g of Candida albicans and Aspergillus brasiliensis (final concentration), the calibrated inoculum was thoroughly mixed into the preparation to ensure uniform distribution of the inoculum. The corresponding containers containing the inoculated preparations were then stored at 22.5 ± 2.5 ° C. At each specified sampling interval (initial (T0), 7 days (T7) and 28 days (T28)), 1 g of the inoculated preparation was taken and dilutions were prepared to perform the counting of surviving microorganisms. Then, for each time and each strain / strain mixture, the average logarithm value was calculated, which is shown in Tables 2 to 6. (Procedure: See ISO 11930, Chapter 5.2 to Chapter 5.6.3.4 (Page 3-13))

[0065] Table 1: O / W emulsions

[0066]

[0067] Table 2: Results for Candida albicans; PTT: 0.4 wt%, HG and EHG: 0.6 wt%

[0068]

[0069]

[0070] As can be seen in the table above, the combination of phytantriol and hexylglycerin exhibited a synergistic effect against Candida albicans. The combination also performed better than the combination of phytantriol and ethylhexylglycerin, a well-known preservative enhancer.

[0071] Table 3: Results for Aspergillus brasiliensis; PTT: 0.1 wt%, HG and EHG: 0.9 wt%

[0072]

[0073] Table 4: Results for Aspergillus brasiliensis; PTT: 0.4 wt%, HG and EHG: 0.6 wt%

[0074]

[0075] Table 5: Aspergillus brasiliensis; PTT: 0.3 wt%, HG and EHG: 0.4 wt%

[0076]

[0077]

[0078] As can be seen from Tables 3 to 5, the combination of phytantriol and hexylglycerol at different concentration levels / weight ratios showed a synergistic effect against Aspergillus brasiliensis. This combination performed better than the combination of phytantriol and ethylhexylglycerol, a well-known preservative synergist.

[0079] Table 6: Bacterial mixture*; PTT: 0.3 wt%, HG and EHG: 0.4 wt%

[0080]

[0081] *Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus

[0082] As can be seen from Table 6, the combination of phytantriol and hexylglycerin also showed a synergistic effect on bacteria. This combination performed better than the combination of phytantriol and ethylhexylglycerin, a well-known preservative synergist.

Claims

1. A topical composition comprising phytantriol and hexylglycerin, wherein the amount of phytantriol is selected from the range of 0.1 wt % to 1 wt %, and the amount of hexylglycerin is selected from the range of 0.1 wt % to 1 wt %, based on the total weight of the composition.

2. The topical composition according to claim 1, wherein the weight ratio of said hexylglycerol to said phytantriol is selected from the range of 5:1 to 1:

5.

3. The topical composition according to claim 2, wherein the weight ratio of the hexylglycerol to the phytantriol is selected from the range of 2.5:1 to 1:2.

5.

4. The topical composition of claim 2, wherein the weight ratio of the hexylglycerin to the phytantriol is selected from the range of 1.5:1 to 1:

1.

5. The topical composition according to any one of claims 1 to 4, wherein the composition is a cosmetic composition or a pharmaceutical composition.

6. The topical composition according to claim 5, wherein the composition is a shampoo preparation, a conditioner, an O / W emulsion, a W / O emulsion or a gel.

7. A topical composition according to any one of claims 1 to 4, wherein the composition comprises water and at least one agent selected from the group consisting of surfactants, thickeners and oils.

8. The topical composition according to claim 7, wherein the composition comprises water and at least one agent selected from the group consisting of emulsifiers.

9. The topical composition according to any one of claims 1 to 4, for use in preventing and / or treating pathological skin conditions by maintaining healthy skin homeostasis and / or maintaining a balanced skin microbiota.

10. Use of a mixture of phytantriol and hexylglycerol as a synergistic antimicrobial mixture, wherein the amount of phytantriol is selected from the range of 0.1 wt % to 1 wt %, and the amount of hexylglycerol is selected from the range of 0.1 wt % to 1 wt %, based on the total weight of the mixture.

11. Use of a mixture of phytantriol and hexylglycerol for reducing or preventing microbial growth during storage of a topical composition according to any one of claims 1 to 7, wherein the amount of phytantriol is selected from the range of 0.1 wt % to 1 wt % and the amount of hexylglycerol is selected from the range of 0.1 wt % to 1 wt %, based on the total weight of the mixture.

12. The use according to claim 11, for improving the shelf life and / or storage stability of the composition.

13. A method for inhibiting or delaying microbial decomposition of a cosmetic composition, household product, plastic, paper and / or paint, wherein the method comprises the step of adding a mixture of phytantriol and hexylglycerol to the cosmetic composition, household product, plastic, paper and / or paint, wherein the amount of phytantriol and hexylglycerol is (i) 0.1 wt % to 1 wt % of phytantriol, based on the total weight of the composition, and (ii) 0.1 wt % to 1 wt % of hexylglycerol, based on the total weight of the composition.

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