Synergistic pulse generating circuit, generating device and generating method thereof

Abstract

The embodiment of the present application provides a collaborative pulse generating circuit, generating device and generating method thereof. The first pulse generating module includes n-level first pulse generating units, which are configured to receive and store the electrical energy provided by the first power supply, and x first pulse generating units that receive the first control signal discharge to form a first pulse applied to the load; the second pulse generating module includes m-level second pulse generating units, which are configured to receive and store the electrical energy provided by the second power supply, and y second pulse generating units that receive the second control signal discharge to form a second pulse applied to the load. This embodiment can selectively form first pulses and / or second pulses of different widths, and can select the voltages of the first pulse and the second pulse, so as to achieve the purpose of applying a composite pulse to the load.

Description

Technical Field

[0001] The present application relates to the field of pulse generation technology, and in particular, to a collaborative pulse generating circuit, a generating device and a generating method thereof. Background Art

[0002] Pulsed power technology is an electrophysical technique that rapidly compresses, converts, or directly releases slowly stored, high-density energy to a load. Since its inception, the technology has been primarily applied in military and defense fields such as particle accelerators, electromagnetic pulse weapons, high-power laser generators, and new weapon research, driving the rapid development of pulsed power technology.

[0003] In recent years, as the application of pulse power technology has continued to expand into fields such as medicine, environmental science, plasma science, food processing, electromagnetic compatibility testing, and bioengineering, the requirements for pulse generators have also continued to improve.

[0004] Traditional pulse generators can usually only generate pulse signals of a specific width, which limits the application of composite pulse technology. Summary of the Invention

[0005] In response to the shortcomings of existing methods, the present application proposes a collaborative pulse generating circuit, generating device and generating method thereof, which can generate pulses of different width ranges and form more pulse combinations, which is conducive to the application of composite pulses.

[0006] In a first aspect, an embodiment of the present application provides a collaborative pulse generating circuit, the collaborative pulse generating circuit including a first power supply, a first pulse generating module electrically connected to the first power supply, a second power supply, and a second pulse generating module electrically connected to the second power supply;

[0007] The first pulse generating module includes n-stage first pulse generating units, each of which is configured to receive and store electric energy provided by the first power supply at a first voltage, and to release the stored electric energy upon receiving a first control signal. The x first pulse generating units receiving the first control signal discharge to form a first pulse applied to a load, where n is an integer greater than or equal to 1, and x is an integer greater than or equal to 1 and less than or equal to n.

[0008] The second pulse generating module includes m-level second pulse generating units, the second pulse generating units being configured to receive and store electric energy provided by the second power supply at a second voltage, and to release the stored electric energy upon receiving a second control signal, wherein y second pulse generating units receiving the second control signal discharge to form a second pulse applied to the load, where m is an integer greater than or equal to 1, and y is an integer greater than or equal to 1 and less than or equal to m;

[0009] The second voltage is greater than the first voltage, the width of the second pulse is smaller than the width of the first pulse, and the time when the second pulse generating unit receives the second control signal is different from the time when the first pulse generating unit receives the first control signal.

[0010] In a second aspect, an embodiment of the present application provides a coordinated pulse generating device, comprising:

[0011] The above-mentioned cooperative pulse generating circuit;

[0012] The control module is electrically connected to the first pulse generating module and the second pulse generating module respectively, and is configured to generate the first control signal and the second control signal according to input information, and transmit the first control signal to the first pulse generating module and transmit the second control signal to the second pulse generating module.

[0013] In a third aspect, an embodiment of the present application provides a collaborative pulse generation method, the method comprising:

[0014] The first pulse generating module includes n first pulse generating units that receive and store electric energy provided by a first power supply at a first voltage, and the second pulse generating module includes m second pulse generating units that receive and store electric energy provided by a second power supply at a second voltage, where n is an integer greater than or equal to 1, m is an integer greater than or equal to 1, and the second voltage is greater than the first voltage;

[0015] x first pulse generating units receive a first control signal and discharge under the control of the first control signal to form a first pulse, where x is an integer greater than or equal to 1 and less than or equal to n;

[0016] y second pulse generating units receive a second control signal and discharge under the control of the second control signal to form a second pulse, y is an integer greater than or equal to 1 and less than or equal to m, a width of the second pulse is smaller than a width of the first pulse, and a time when the second pulse generating unit receives the second control signal is different from a time when the first pulse generating unit receives the first control signal;

[0017] The first pulse and / or the second pulse are applied to a load.

[0018] The beneficial technical effects brought about by the technical solutions provided by the embodiments of the present application are:

[0019] The collaborative pulse generating circuit, generating device and generating method provided in the embodiments of the present application can selectively form a first pulse and / or a second pulse of different widths, and can select the voltage of the first pulse and the second pulse, so as to achieve the purpose of applying a composite pulse to a load. Taking tumor cells as an example, the effect of the composite pulse is beneficial to improving the ablation effect of tumor cells. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0021] Figure 1 A schematic structural diagram of a collaborative pulse generating circuit provided in an embodiment of the present application;

[0022] Figure 2 A schematic structural diagram of another collaborative pulse generating circuit provided in an embodiment of the present application;

[0023] Figure 3 A schematic diagram of the specific structure of a collaborative pulse generating circuit provided in an embodiment of the present application;

[0024] Figure 4 A schematic structural diagram of a collaborative pulse generating device provided in an embodiment of the present application;

[0025] Figure 5 A flowchart of a collaborative pulse generation method provided in an embodiment of the present application.

[0026] Reference numerals:

[0027] 1-first pulse generating module; 11-first pulse generating unit; 111-first storage unit; 112-first switching unit; 113-first cutoff unit;

[0028] 2-second pulse generating module; 21-second pulse generating unit; 211-second storage unit; 212-second switching unit; 213-second cutoff unit;

[0029] 3- Load;

[0030] U1-first power supply; U2-second power supply. DETAILED DESCRIPTION

[0031] The present application is described in detail below. Examples of embodiments of the present application are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar components or components having the same or similar functions. In addition, if the detailed description of the known technology is not necessary for the features of the present application shown, it will be omitted. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application and are not to be construed as limiting the present application.

[0032] It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by those skilled in the art to which this application belongs. It should also be understood that terms such as those defined in common dictionaries should be understood to have meanings consistent with their meanings in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless specifically defined as herein.

[0033] Those skilled in the art will understand that, unless otherwise stated, the singular forms "a," "an," "said," and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of this application refers to the presence of features, integers, steps, operations, elements, and / or components, but does not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof.

[0034] In recent years, as the application of pulse power technology has continued to expand into fields such as medicine, environmental science, plasma science, food processing, electromagnetic compatibility testing, and bioengineering, the requirements for pulse generators have also continued to improve.

[0035] Taking the medical field as an example, a single pulse has a poor ablation effect on tumor cells. Specifically, when a microsecond pulse acts on tumor cells, although it has a larger ablation area, the ablation rate of tumor cells, especially malignant tumor cells with higher distortion, is low. When a nanosecond pulse acts on tumor cells, although it has a higher ablation rate, the ablation area is smaller. The combined use of microsecond pulses and nanosecond pulses can significantly improve the ablation effect of tumor cells.

[0036] However, traditional pulse generators can usually only generate pulse signals of a specific width, which limits the application of composite pulse technology.

[0037] The collaborative pulse generating circuit, generating device and generating method provided in this application are intended to solve the above technical problems in the prior art.

[0038] The following describes in detail the technical solution of the present application and how the technical solution of the present application solves the above-mentioned technical problems with specific embodiments.

[0039] The embodiment of the present application provides a cooperative pulse generating circuit, such as Figure 1 As shown, the coordinated pulse generating circuit includes a first power supply U1, a first pulse generating module 1 electrically connected to the first power supply U1, a second power supply U2, and a second pulse generating module 2 electrically connected to the second power supply U2;

[0040] The first pulse generating module 1 includes n-stage first pulse generating units 11, which are configured to receive and store electric energy provided by the first power supply U1 at a first voltage, and release the stored electric energy when receiving a first control signal. The x first pulse generating units 11 receiving the first control signal discharge to form a first pulse applied to the load 3, where n is an integer greater than or equal to 1, and x is an integer greater than or equal to 1 and less than or equal to n.

[0041] The second pulse generating module 2 includes m-level second pulse generating units 21, which are configured to receive and store electric energy provided by the second power supply U2 at a second voltage, and release the stored electric energy upon receiving a second control signal. Y second pulse generating units 21 that receive the second control signal discharge to form a second pulse applied to the load 3, where m is an integer greater than or equal to 1, and y is an integer greater than or equal to 1 and less than or equal to m.

[0042] The second voltage is greater than the first voltage, the width of the second pulse is less than the width of the first pulse, and the time when the second pulse generating unit 21 receives the second control signal is different from the time when the first pulse generating unit 11 receives the first control signal.

[0043] It should be noted that, in theory, the x first pulse generating units 11 that receive the first control signal all discharge at the first voltage. However, in practice, due to the influence of factors such as the resistance of each component in the pulse generating circuit, the discharge voltage of the first pulse generating unit 11 will be slightly lower than the first voltage, but the difference with the first voltage is very small. Therefore, the voltage of the first pulse applied to the load 3 can be approximated to x times the first voltage; similarly, the voltage of the second pulse applied to the load 3 can be approximated to y times the second voltage. For ease of explanation, in the subsequent embodiments, the actual voltage values of the first pulse generating unit 11 and the second pulse generating unit 21 when discharging will no longer be explained, and they will all be described in terms of the first voltage and the second unit. Based on the above description, by setting the number of first pulse generating units 11 and second pulse generating units 21 that discharge simultaneously, the voltage of the first pulse and the voltage of the second pulse can be adjusted.

[0044] It should be noted that the time when the second pulse generating unit 21 receives the second control signal is different from the time when the first pulse generating unit 11 receives the first control signal, which means that when the second pulse generating unit 21 receives the second control signal, the first pulse generating unit 11 will not receive the first control signal, and when the first pulse generating unit 11 receives the first control signal, the second pulse generating unit 21 will not receive the second control signal, that is, the first pulse and the second pulse will not be formed at the same time to avoid mutual interference between the first pulse and the second pulse.

[0045] By making the first control signal and the second control signal different, different pulse combinations can be formed. For example, in one specific embodiment, the pulse combination includes a plurality of first pulse groups, with a time interval t1 between two adjacent first pulse groups, each first pulse group including a first pulses, and a time interval t2 between two adjacent first pulses. In another specific embodiment, the pulse combination includes a plurality of second pulse groups, with a time interval t3 between two adjacent second pulse groups, each second pulse group including b second pulses, and a time interval t4 between two adjacent second pulses. In yet another specific embodiment, the pulse combination includes a plurality of first pulses and a plurality of second pulses, and the first pulses and the second pulses may be applied alternately to the load 3, or all the first pulses may be applied to the load 3 before the second pulse is applied to the load 3, or all the second pulses may be applied to the load 3 before the second pulse is applied to the load 3, or the first pulses may form a plurality of first pulse groups, and the second pulses may form a plurality of second pulse groups, and the first pulse groups and the second pulse groups may be applied alternately to the load 3.

[0046] The collaborative pulse generating circuit in this embodiment can selectively form a first pulse and / or a second pulse with different widths, and can select the voltage of the first pulse and the second pulse, so as to achieve the purpose of applying a composite pulse to the load 3. Taking the load 3 as a tumor cell as an example, the effect of the composite pulse is beneficial to improving the ablation effect of the tumor cells.

[0047] In the above embodiment, the optional framework of the collaborative pulse generating circuit is described. In the following embodiment, the structure of the first pulse generating units 11 at each stage in the first pulse generating module 1 and the connection relationship of the first pulse generating units 11 at each stage, and the structure of the second pulse generating units 21 at each stage in the second pulse generating module 2 and the connection relationship of the second pulse generating units 21 at each stage will be described in detail.

[0048] In an optional embodiment, if Figure 2As shown, the first pulse generating unit 11 in the cooperative pulse generating circuit includes a first storage unit 111 , a first switch unit 112 and a first cutoff unit 113 , and the second pulse generating unit 21 includes a second storage unit 211 , a second switch unit 212 and a second cutoff unit 213 .

[0049] like Figure 2 As shown, the first switch unit 112 is configured to be turned on under the control of the first control signal, so that the monitoring first storage units 111 at the same level as the monitoring first switch unit 112 that receives the monitoring first control signal are connected in series and discharged to form a monitoring first pulse; Figure 2 As shown, the first cutoff unit 113 is configured to only allow current to flow from the first power supply U1 to the first pulse generating unit 11 , or from the first pulse generating unit 11 of this stage to the first pulse generating unit 11 of the next stage.

[0050] Specifically, when discharging, only the first switching unit 112 that receives the first control signal is turned on. At the same time, due to the unidirectional cut-off effect of the first cut-off unit 113, the first storage unit 111 in the first pulse generating unit 11 that receives the first control signal is connected in series and discharged. The first storage unit 111 is equivalent to a power supply during the discharge process. These series-connected power supplies are discharged at the first voltage at the same time. If there are x first storage units 111 in the n-level first storage units 111 that are connected in series and discharged, the voltage of the formed first pulse is x times the first voltage.

[0051] like Figure 2 As shown, the second switch unit 212 is configured to be turned on under the control of the second control signal, so that the monitoring second storage units 211 of the same level in the monitoring second switch unit 212 that receives the monitoring second control signal are connected in series and discharged to form a monitoring second pulse; the second cut-off unit 213 is configured to only allow current to flow from the second power supply U2 to the second pulse generating unit 21, or from the second pulse generating unit 21 of this level to the second pulse generating unit 21 of the next level.

[0052] Specifically, when discharging, only the second switching unit 212 that receives the second control signal is turned on. At the same time, due to the unidirectional cut-off effect of the second cut-off unit 213, the second storage unit 211 in the second pulse generating unit 21 that receives the second control signal is connected in series and discharged. The second storage unit 211 is equivalent to a power supply during the discharge process. These series-connected power supplies are discharged at the second voltage at the same time. If there are y second storage units 211 in the m-level second storage units 211 that are connected in series and discharged, the voltage of the formed second pulse is y times the second voltage.

[0053] like Figure 2As shown, the first switch unit 112 is further configured to be disconnected upon receiving the third control signal, so that the first storage units 111 of each level are connected in parallel to the first power supply U1 and receive and store the electric energy provided by the first power supply U1; the second switch unit 212 is further configured to be disconnected upon receiving the fourth control signal, so that the second storage units 211 of each level are connected in parallel to the second power supply U2 and receive and store the electric energy provided by the second power supply U2.

[0054] Specifically, when the first switch unit 112 is in the off state, due to the unidirectional cut-off effect of the first cut-off unit 113, the first storage units 111 of each level are connected in parallel and store the electric energy provided by the first power supply U1 at the first voltage. Similarly, the second storage units 211 of each level are also connected in parallel and store the electric energy provided by the first power supply U1 at the first voltage.

[0055] In a specific embodiment, Figure 3 As shown, in the collaborative pulse generating circuit, the first cut-off unit 113 includes a first cut-off device and a second cut-off device, the first cut-off device of the first stage is electrically connected to the first end of the first power supply U1 and the first end of the first storage unit 111 of the first stage, respectively, the first cut-off device of the i-th stage is electrically connected to the first end of the first storage unit 111 of the i-1-th stage, the first end of the first storage unit 111 of the i-th stage and the first cut-off device of the i-1-th stage, respectively, the second cut-off devices of each stage are electrically connected to the second end of the first storage unit 111 of the current stage, the second end of the first switch of the current stage and the second cut-off device of the next stage, respectively, and i is an integer greater than or equal to 2.

[0056] like Figure 3 As shown, in the collaborative pulse generating circuit, the second cutoff unit 213 includes a third cutoff device and a fourth cutoff device, the first-level third cutoff device is electrically connected to the first end of the second power supply U2 and the first end of the first-level second storage unit 211, respectively, the j-th level third cutoff device is electrically connected to the first end of the j-1-th level second storage unit 211, the first end of the j-th level second storage unit 211 and the j-1-th level third cutoff device, and the fourth cutoff device of each level is electrically connected to the second end of the second storage unit 211 of this level, the second end of the second switch of this level and the fourth cutoff device of the next level, respectively, and j is an integer greater than or equal to 2.

[0057] Furthermore, if Figure 3As shown, the two ends of the first storage unit 111 of each level are respectively electrically connected to the two ends of the first power supply U1, the control end of the first switch unit 112 of each level is configured to receive a first control signal, and the first end and the second end of the first switch unit 112 of each level are respectively electrically connected to the first end of the first storage unit 111 of the current level and the second end of the first storage unit 111 of the next level; the two ends of the second storage unit 211 of each level are respectively electrically connected to the two ends of the second power supply U2, the control end of the second switch unit 212 of each level is configured to receive a second control signal, and the first end and the second end of the second switch of each level are respectively electrically connected to the first end of the second storage unit 211 of the current level and the second end of the second storage unit 211 of the next level.

[0058] In this specific embodiment, the first storage unit 111 includes a first capacitor, the second storage unit 211 includes a second capacitor; the first switching unit includes a first transistor, the second switching unit 212 includes a second transistor; the first cutoff device includes a first diode, the second cutoff device includes a second diode, the third cutoff device includes a third diode, and the fourth cutoff device includes a fourth diode. In other words, capacitors are used as storage units, transistors are used as switching units, and diodes are used as cutoff devices.

[0059] Please refer to further Figure 3 In this collaborative pulse generating circuit, the first pulse generating module 1 includes four stages of first pulse generating units 11, and the second pulse generating module 2 includes three stages of second pulse generating units 21, i.e., n is equal to 4, and m is equal to 3. It should be noted that this is merely an exemplary description and is not intended to limit the number of stages of the first pulse generating units 11 in the first pulse generating module 1, or the number of stages of the second pulse generating units 21 in the second pulse generating module 2.

[0060] like Figure 3 As shown, the first switching units 112 of the first to fourth stages, that is, the first transistors of the first to fourth stages are transistors S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 ; The first switch storage of level 1 to level 4 is capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 ; The first cutoff devices of the 1st to 4th stages are diodes D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 The second cutoff devices of the 1st to 4th stages are diodes D 2-1 , diode D 2-2 , diode D2-3 and diode D 2-4 .

[0061] like Figure 3 As shown, the first to fourth stage second switch units 212, that is, the first to fourth stage second transistors are transistors S 2-1 , transistor S 2-2 , transistor S 2-3 And transistor S 2-4 ; The second storage units 211 of the first to fourth levels are capacitors C 2-1 , capacitor C 2-2 , capacitor C 2-3 and capacitor C 2-4 ; The third cutoff devices of the 1st to 4th stages are diodes D 3-1 , diode D 3-2 , diode D 3-3 and diode D 3-4 ; The fourth cutoff devices of the 1st to 4th stages are diodes D 4-1 , diode D 4-2 and diode D 4-3 .

[0062] like Figure 3 As shown, in the cooperative pulse generating circuit, the first power supply U1 supplies power to the first storage unit 111, that is, to the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 When charging, the current flows through the second cutoff device, namely the diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 The second power supply U2 supplies power to the second storage unit 211, that is, to the capacitor C 2-1 , capacitor C 2-2 , capacitor C 2-3 When charging, current also flows through diode D 2-1 , diode D 2-2 and diode D 2-3 .

[0063] like Figure 3 As shown, in this cooperative pulse generating circuit, the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 During discharge, the current flows through the fourth cut-off device, namely diode D 4-1 , diode D 4-2 , diode D 4-3 . The capacitor C 2-1, capacitor C 2-2 , capacitor C 2-3 During discharge, current also flows through diode D 4-1 , diode D 4-2 , diode D 4-3 .

[0064] The first pulse generating module 1 and the second pulse generating module 2 in the collaborative pulse generating circuit provided in this embodiment can not only realize the generation of composite pulses, but also reduce the wiring space, that is, a circuit board with a smaller area can be used as the carrier of the collaborative pulse generating circuit in this embodiment.

[0065] like Figure 3 As shown, the first power supply U1 and the second power supply U2 are both constant voltage power supplies. When the transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 When receiving the third control signal, transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 Both are in the off state, diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 and diode D 2-3 With unidirectional conduction function, the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 They are in parallel and are electrically connected to the first and second terminals of the first power supply U1, that is, they are electrically connected to the positive and negative electrodes of the first power supply U1. 1-1 , capacitor C 1-2 and capacitor C 1-3 The potential difference between the two ends is the first voltage.

[0066] Similarly, if Figure 3 As shown, when transistor S 2-1 , transistor S 2-2 And transistor S 2-3 When both receive the fourth control signal, the capacitor C 2-1 , capacitor C 2-2 , and capacitor C 2-3 The capacitors C are connected in parallel and are both electrically connected to the first and second terminals of the second power supply U2, that is, they are both electrically connected to the positive and negative terminals of the second power supply U2. 2-1 , capacitor C2-2 and capacitor C 2-3 The potential difference between the two ends is the second voltage.

[0067] like Figure 3 As shown, when transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 When both receive the first control signal, transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 Both are in the on state, because the diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 With unidirectional conduction function, the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 is in series relationship, and the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 Discharging is performed simultaneously, and the discharge voltage is the first voltage, so the voltage of the formed pulse is four times the first voltage.

[0068] Similarly, if Figure 3 As shown, when transistor S 2-1 , transistor S 2-2 And transistor S 2-3 When both receive the second control signal, transistor S 2-1 , transistor S 2-2 And transistor S 2-3 Both are in the on state, capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 is in series relationship, and the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 Discharging is performed simultaneously, and the discharge voltage is the second voltage, so the voltage of the formed second pulse is three times the second voltage.

[0069] Further, if Figure 3As shown, in the collaborative pulse generating circuit, the first cut-off devices of the 2nd to nth levels each include a first diode, the second cut-off devices of each level each include a second diode, and the reverse breakdown voltage of the first diode and the reverse breakdown voltage of the second diode are both greater than the first voltage; the third cut-off devices of the 2nd to mth levels each include a third diode, and the fourth cut-off devices of each level each include a fourth diode, and the reverse breakdown voltage of the third diode and the reverse breakdown voltage of the fourth diode are both greater than the second voltage; the first cut-off device of the first pole includes s first diodes, and s times the reverse breakdown voltage of the first diode is greater than (n-1) times the first voltage, and the third cut-off device of the first pole includes t third diodes, and s times the reverse breakdown voltage of the third diode is greater than (m-1) times the second voltage, s is an integer greater than or equal to 1, and t is an integer greater than or equal to 1.

[0070] by Figure 3 Taking the collaborative pulse generating circuit shown as an example, the first pulse generating module 1 includes a four-stage first pulse generating unit 11, and the second pulse generating module 2 includes a three-stage second pulse generating unit 21. If all the diodes used as cutoff devices have the same parameters, since the first voltage is lower than the second voltage, to ensure that each diode can properly function as a unidirectional cutoff, the second voltage should be used as the selection basis. For example, if the second voltage is 1000V, the reverse breakdown voltage of each diode should be greater than 1000V.

[0071] like Figure 3 As shown, if the first voltage is 200V, the second voltage is 1000V, and the ground level is 0V, the reverse breakdown voltage of each diode is 1100V. 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 are both in the on state, then the capacitor C 1-1 The voltage of the end connected to the positive electrode of the first power supply U1 is 800V. At this time, the diode D 1-1 The voltage difference between the two ends is 800V, so a diode D is set 1-1 If the first voltage is 500V, transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 are both in the on state, then the capacitor C 1-1 The voltage of the end connected to the positive electrode of the first power supply U1 is 2000V. At this time, the diode D 1-1 The voltage difference between the two ends is 1500V, so two diodes D should be set 1-1 That's it.

[0072] Similarly, if Figure 3 As shown, if the second voltage is 1000V, the ground level is 0V, and the reverse breakdown voltage of each diode is 1100V, when the transistor S 2-1 , transistor S 2-2 , transistor S 2-3 are both in the on state, then the capacitor C 2-1 The voltage of the end connected to the positive electrode of the second power supply U2 is 3000V. At this time, the diode D 3-1 The voltage difference between the two ends is 2000V, so two diodes D are needed. 3-1 .

[0073] Based on the same inventive concept, the present application also provides a collaborative pulse generating device, such as Figure 4 As shown, the collaborative pulse generating device includes the collaborative pulse generating circuit and control module in the above embodiment. The control module is electrically connected to the first pulse generating module 1 and the second pulse generating module 2, respectively, and is configured to generate a first control signal and a second control signal according to input information, and transmit the first control signal to the first pulse generating module 1, and transmit the second control signal to the second pulse generating module 2.

[0074] The cooperative pulse generating device provided in this embodiment includes the beneficial effects of the cooperative pulse generating circuit in the above-mentioned embodiment, which will not be described in detail here.

[0075] Specifically, the coordinated pulse generator in this embodiment is a micro-nano knife system. In this case, the first pulse is a microsecond pulse, and the second pulse is a nanosecond pulse. The micro-nano knife system can generate a combination of nanosecond and microsecond pulses. By applying this combination of nanosecond and microsecond pulses to tumor tissue, the ablation effect of the tumor tissue can be effectively enhanced.

[0076] Based on the same inventive concept, the present application also provides a method for generating a coordinated pulse, such as Figure 5 As shown, the coordinated pulse generation method includes:

[0077] S1: The n-level first pulse generating unit 11 included in the first pulse generating module 1 receives and stores the electric energy provided by the first power supply U1 at a first voltage, and the m-level second pulse generating unit 21 included in the second pulse generating module 2 receives and stores the electric energy provided by the second power supply U2 at a second voltage, where the second voltage is greater than the first voltage, n is an integer greater than or equal to 1, and m is an integer greater than or equal to 1.

[0078] It should be noted that the charging process of the first pulse generating module 1 and the charging process of the second pulse generating module 2 can be carried out simultaneously, or only the first pulse generating module 1 or the second pulse generating module 2 can be charged, or the charging process of the first pulse generating module 1 and the charging process of the second pulse generating module 2 can be carried out at different times.

[0079] Specifically, the first pulse generating module 1 includes n-stage first pulse generating units 11 that receive and store the electric energy provided by the first power supply U1 at a first voltage, including: each first switching unit 112 is disconnected upon receiving a third control signal, so that the first storage units 111 at each stage are connected in parallel to the first power supply U1 and receive and store the electric energy provided by the first power supply U1.

[0080] by Figure 3 As an example of the cooperative pulse generating circuit shown in FIG, the charging process of the first pulse generating module 1 is as follows: when the transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 When receiving the third control signal, transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 Both are in the off state, diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 With unidirectional conduction function, the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 They are in parallel and are electrically connected to the first and second terminals of the first power supply U1, that is, they are electrically connected to the positive and negative electrodes of the first power supply U1. 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 When the potential difference between the two ends is the first voltage, the first pulse generating module 1 completes charging.

[0081] Specifically, the second pulse generating module 2 includes m-level second pulse generating units 21 that receive and store the electric energy provided by the second power supply U2 at a second voltage, including: each second switching unit 212 is disconnected upon receiving a fourth control signal, so that the second storage units 211 at each level are connected in parallel to the second power supply U2 and receive and store the electric energy provided by the second power supply U2.

[0082] by Figure 3 As an example of the cooperative pulse generating circuit shown in FIG. 1 , the charging process of the second pulse generating module 2 is as follows: the transistor S 2-1 , transistor S 2-2 And transistor S 2-3 When receiving the fourth control signal, transistor S 2-1 , transistor S 2-2 And transistor S 2-3 Both are in the off state, diode D 3-1 , diode D 3-2 , diode D 3-3 , diode D 3-4 , diode D 4-1 , diode D 4-2 and diode D 4-3 With unidirectional conduction function, the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 They are in parallel and are electrically connected to the first and second terminals of the second power supply U2, that is, they are electrically connected to the positive and negative electrodes of the second power supply U2. 2-1 , capacitor C 2-2 and capacitor C 2-3 When the potential difference between the two ends is the second voltage, the second pulse generating module 2 completes charging.

[0083] In a specific embodiment, the first control signal and the second control signal are both at a high level, while the third control signal and the fourth control signal are both at a low level. That is, as long as the first pulse generating module 1 does not receive the first control signal, the first power supply U1 is in a state of charging the first capacitors of each level or maintaining the voltage difference across the first capacitors of each level at the first voltage. Similarly, as long as the second pulse generating module 2 does not receive the second control signal, the second power supply U2 is in a state of charging the second capacitors of each level or maintaining the voltage difference across the second capacitors of each level at the second voltage.

[0084] S2: x first pulse generating units 11 receive the first control signal and discharge under the control of the first control signal to form a first pulse applied to the load 3, where x is an integer greater than or equal to 1 and less than or equal to n.

[0085] Specifically, if Figure 5As shown, the first pulse generating unit 11 includes a first storage unit 111, a first switch unit 112, and a first cutoff unit 113. The first cutoff unit 113 only allows current to flow from the first power supply U1 to the first pulse generating unit 11, or from the first pulse generating unit 11 of the current stage to the first pulse generating unit 11 of the next stage. At this time, step S2 includes: x first switch units 112 receive a first control signal and are turned on under the control of the first control signal, so that the x first storage units 111 of the same stage as the first switch unit 112 that receives the first control signal are connected in series and discharge to form a first pulse.

[0086] Specifically, if Figure 3 As shown, the first cutoff unit 113 includes a first cutoff device and a second cutoff device. The first storage unit 111 includes a first capacitor, and the first switch unit 112 includes a first transistor. The first cutoff device includes a first diode, and the second cutoff device includes a second diode. In this coordinated pulse generation circuit, the first pulse generation module 1 includes four stages of first pulse generation units 11, i.e., n equals 4.

[0087] like Figure 3 As shown, the first switching units 112 of the first to fourth stages, that is, the first transistors of the first to fourth stages are transistors S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 ; The first switch storage of the 1st to 4th level, that is, the first capacitors of the 1st to 4th level are capacitors C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 ; The first cut-off devices of the 1st to 4th stages, that is, the first diodes of the 1st to 4th stages are diodes D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 ; The second cutoff device of the 1st to 4th stage, the second diode of the 1st to 4th stage is diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 .

[0088] like Figure 3 As shown, when transistor S 1-1 , transistor S 1-2 , transistor S 1-3 And transistor S 1-4 When both receive the first control signal, transistor S 1-1 , transistor S 1-2 , transistor S1-3 And transistor S 1-4 Both are in the on state, because the diode D 1-1 , diode D 1-2 , diode D 1-3 and diode D 1-4 , diode D 2-1 , diode D 2-2 , diode D 2-3 and diode D 2-4 With unidirectional conduction function, the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 is in series relationship, and the capacitor C 1-1 , capacitor C 1-2 , capacitor C 1-3 and capacitor C 1-4 Discharging is performed simultaneously, and the discharge voltage is the first voltage, so the voltage of the formed pulse is four times the first voltage.

[0089] S3: y second pulse generating units 21 receive the second control signal and discharge under the control of the second control signal to form a second pulse applied to the load 3, y is an integer greater than or equal to 1 and less than or equal to m, the width of the second pulse is smaller than the width of the first pulse, and the time when the second pulse generating unit 21 receives the second control signal is different from the time when the first pulse generating unit 11 receives the first control signal.

[0090] Specifically, if Figure 5 As shown, the second pulse generating unit 21 includes a second storage unit 211, a second switch unit 212, and a second cutoff unit 213. The second cutoff unit 213 only allows current to flow from the second power supply U2 to the second pulse generating unit 21, or from the second pulse generating unit 21 of the current stage to the second pulse generating unit 21 of the next stage. At this time, step S3 includes: y second switch units 212 receive the second control signal and are turned on under the control of the second control signal, so that the y second storage units 211 at the same stage as the second switch unit 212 that received the second control signal are connected in series and discharge to form a second pulse.

[0091] Specifically, if Figure 3 As shown, the second cutoff unit 213 includes a third cutoff device and a fourth cutoff device. The second storage unit 211 includes a second capacitor; the second switch unit 212 includes a second transistor; the third cutoff device includes a third diode, and the fourth cutoff device includes a fourth diode. In this coordinated pulse generation circuit, the second pulse generation module 2 includes four stages of second pulse generation units 21, i.e., m equals 3.

[0092] like Figure 3 As shown, the first to fourth stage second switch units 212, namely the first to third stage second transistors are transistors S 2-1 , transistor S 2-2 And transistor S 2-3 ; The second storage unit 211 of the first to third levels, that is, the second capacitors of the first to third levels are capacitors C 2-1 , capacitor C 2-2 and capacitor C 2-3 ; The third cut-off device from the first to the third stage, that is, the third diode from the first to the third stage is diode D 3-1 , diode D 3-2 and diode D 3-3 ; The fourth cut-off device from the first to the third stage, that is, the fourth diode from the first to the third stage is diode D 4-1 , diode D 4-2 and diode D 4-3 .

[0093] like Figure 3 As shown, when transistor S 2-1 , transistor S 2-2 And transistor S 2-3 When both receive the second control signal, transistor S 2-1 , transistor S 2-2 And transistor S 2-3 Both are in the on state, capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 is in series relationship, and the capacitor C 2-1 , capacitor C 2-2 and capacitor C 2-3 Discharging is performed simultaneously, and the discharge voltage is the second voltage, so the voltage of the formed second pulse is three times the second voltage.

[0094] S4 : Applying the first pulse and / or the second pulse to the load 3 .

[0095] The collaborative pulse generation method in this embodiment can selectively form a first pulse and a second pulse of different widths, and can select the voltages of the first pulse and the second pulse, so as to achieve the purpose of applying a composite pulse to load 3. Taking load 3 as tumor cells as an example, the effect of the composite pulse is beneficial to improving the ablation effect of tumor cells.

[0096] It should be noted that the collaborative pulse generation method provided in this embodiment may include only one of step S1 and step S2, or may include both, and the order of step S1 and step S2 can be adjusted according to actual needs, that is, different pulse combinations can be output according to actual needs. In a specific embodiment, the pulse combination includes a plurality of first pulse groups, the interval between two adjacent first pulse groups is t1, each first pulse group includes a first pulses, and the interval between two adjacent first pulses is t2, that is, only step S1 of the two steps S1 and step S2 is included. In another specific embodiment, the pulse combination includes a plurality of second pulse groups, the interval between two adjacent second pulse groups is t3, each second pulse group includes b second pulses, and the interval between two adjacent second pulses is t4, that is, only step S2 of the two steps S1 and step S2 is included. In another specific embodiment, the pulse combination includes multiple first pulses and multiple second pulses. The first pulses and the second pulses may be applied alternately to the load 3, or the second pulses may be applied to the load 3 after all the first pulses are applied to the load 3, or the second pulses may be applied to the load 3 after all the second pulses are applied to the load 3. The first pulses may form multiple first pulse groups, and the second pulses may form multiple second pulse groups. The first pulse groups and the second pulse groups may be applied alternately to the load 3, that is, step S1 and step S2 are included at the same time.

[0097] By applying the embodiments of the present application, at least the following beneficial effects can be achieved:

[0098] The collaborative pulse generating circuit, generating device and generating method provided in the embodiments of the present application can selectively form a first pulse and / or a second pulse of different widths, and can select the voltage of the first pulse and the second pulse, so as to achieve the purpose of applying a composite pulse to a load. Taking tumor cells as an example, the effect of the composite pulse is beneficial to improving the ablation effect of tumor cells.

[0099] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature specified as "first" or "second" may explicitly or implicitly include one or more of such features. Throughout this application, unless otherwise specified, "plurality" means two or more.

[0100] In the description of this application, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to direct connections, indirect connections through an intermediate medium, or internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on the specific circumstances.

[0101] In the description of this specification, specific features, structures, materials or characteristics may be combined in an appropriate manner in any one or more embodiments or examples.

[0102] The above are only some of the implementation methods of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A collaborative pulse generating circuit, characterized in that: It includes a first power supply, a first pulse generating module electrically connected to the first power supply, a second power supply, and a second pulse generating module electrically connected to the second power supply; The first pulse generating module includes n-stage first pulse generating units, and the first pulse generating units include a first storage unit, a first switch unit and a first cut-off unit; The first switching unit is configured to be disconnected upon receiving a third control signal, so that each of the first storage units is connected in parallel to the first power supply and receives and stores electrical energy provided by the first power supply at a first voltage, and the x first switching units receive a first control signal and are turned on under the control of the first control signal, so that each of the first storage units at the same level as the first switching unit that receives the first control signal is connected in series and discharges to form a first pulse applied to a load; the first cut-off unit is configured to only allow a charging current to flow from the first power supply to the first pulse generating unit, or from the first pulse generating unit of the current level to the first pulse generating unit of the next level, and only allow a discharging current to flow from the first pulse generating unit of the current level to the first pulse generating unit of the next level; n is an integer greater than or equal to 1, and x is an integer greater than or equal to 1 and less than or equal to n; The second pulse generating module includes m-stage second pulse generating units, and the second pulse generating units include a second storage unit, a second switch unit and a second cut-off unit; The second switching unit is configured to be disconnected upon receiving a fourth control signal, so that the second storage units at each level are connected in parallel to the second power supply and receive and store the electric energy provided by the second power supply at a second voltage, and y second switching units receive a second control signal and are turned on under the control of the second control signal, so that the second storage units at the same level in the second switching units that receive the second control signal are connected in series and discharge to form a second pulse applied to the load; the second cut-off unit is configured to only allow charging current to flow from the second power supply to the second pulse generating unit, or from the second pulse generating unit of the current level to the second pulse generating unit of the next level, and only allow discharging current to flow from the first pulse generating unit of the current level to the first pulse generating unit of the next level; m is an integer greater than or equal to 1, and y is an integer greater than or equal to 1 and less than or equal to m; The second voltage is greater than the first voltage, the width of the second pulse is smaller than the width of the first pulse, and the time when the second pulse generating unit receives the second control signal is different from the time when the first pulse generating unit receives the first control signal.

2. The cooperative pulse generating circuit according to claim 1, characterized in that: The first cutoff unit includes a first cutoff device and a second cutoff device, the first cutoff device of the first stage is electrically connected to the first end of the first power supply and the first end of the first storage unit of the first stage, respectively; the first cutoff device of the i-th stage is electrically connected to the first end of the first storage unit of the i-1-th stage, the first end of the first storage unit of the i-th stage, and the first cutoff device of the i-1-th stage, respectively; the second cutoff device of each stage is electrically connected to the second end of the first storage unit of the current stage, the second end of the first switch of the current stage, and the second cutoff device of the next stage, respectively, where i is an integer greater than or equal to 2; The second cut-off unit includes a third cut-off device and a fourth cut-off device, the third cut-off device of the first level is electrically connected to the first end of the second power supply and the first end of the second storage unit of the first level, respectively, the third cut-off device of the jth level is electrically connected to the first end of the second storage unit of the j-1th level, the first end of the second storage unit of the j-1th level, and the third cut-off device of the j-1th level, respectively, the fourth cut-off device of each level is electrically connected to the second end of the second storage unit of the current level, the second end of the second switch of the current level, and the fourth cut-off device of the next level, respectively, where j is an integer greater than or equal to 2.

3. The cooperative pulse generating circuit according to claim 2, characterized in that: Two ends of the first storage unit at each stage are electrically connected to two ends of the first power supply, respectively; a control end of the first switch unit at each stage is configured to receive the first control signal; a first end and a second end of the first switch at each stage are electrically connected to the first end of the first storage unit at the current stage and the second end of the first storage unit at the next stage, respectively; The two ends of the second storage unit at each level are electrically connected to the two ends of the second power supply respectively, the control end of the second switch unit at each level is configured to receive the second control signal, and the first end and the second end of the second switch at each level are electrically connected to the first end of the second storage unit at the current level and the second end of the second storage unit at the next level respectively.

4. The cooperative pulse generating circuit according to claim 3, characterized in that: The first storage unit includes a first capacitor, and the second storage unit includes a second capacitor; The first switch unit includes a first transistor, and the second switch unit includes a second transistor; The first cutoff device includes a first diode, the second cutoff device includes a second diode, the third cutoff device includes a third diode, and the fourth cutoff device includes a fourth diode; The current generated when the second power supply charges the second pulse generating module flows through each stage of the second cut-off device; The first pulse generated when the first pulse generating module discharges flows through each stage of the fourth cut-off device.

5. The cooperative pulse generating circuit according to claim 4, characterized in that: The first cutoff devices of the second to nth stages each include a first diode, and the second cutoff devices of each stage each include a second diode, and the reverse breakdown voltage of the first diode and the reverse breakdown voltage of the second diode are both greater than the first voltage; The third cutoff devices of the second to mth stages each include a third diode, and the fourth cutoff devices of each stage each include a fourth diode, and the reverse breakdown voltage of the third diode and the reverse breakdown voltage of the fourth diode are both greater than the second voltage; The first cutoff device at the first pole includes s first diodes, s times of the reverse breakdown voltage of the first diode is greater than (n-1) times of the first voltage, and s is an integer greater than or equal to 1; The third cutoff device at the first pole includes t third diodes, s times the reverse breakdown voltage of the third diode is greater than (m-1) times the second voltage, and t is an integer greater than or equal to 1.

6. A collaborative pulse generating device, characterized in that: include: The cooperative pulse generating circuit according to any one of claims 1 to 5; The control module is electrically connected to the first pulse generating module and the second pulse generating module respectively, and is configured to generate the first control signal and the second control signal according to input information, and transmit the first control signal to the first pulse generating module and transmit the second control signal to the second pulse generating module.

7. A collaborative pulse generation method, characterized in that: include: The first pulse generating module includes n-stage first pulse generating units, each of which includes a first storage unit, a first switch unit, and a first cutoff unit. The first cutoff unit only allows current to flow from the first power supply to the first pulse generating unit, or from the first pulse generating unit of the current stage to the first pulse generating unit of the next stage. Each of the first switch units is disconnected upon receiving a third control signal, so that each of the first storage units is connected in parallel to the first power supply and receives and stores electrical energy provided by the first power supply at a first voltage; The second pulse generating module includes m stages of second pulse generating units, each of which includes a second storage unit, a second switch unit, and a second cutoff unit. The second cutoff unit only allows current to flow from the second power supply to the second pulse generating unit, or from the second pulse generating unit of the current stage to the second pulse generating unit of the next stage. Each of the second switch units is disconnected upon receiving a fourth control signal, so that each of the second storage units is connected in parallel to the second power supply and receives and stores electrical energy provided by the second power supply at a second voltage; n is an integer greater than or equal to 1, m is an integer greater than or equal to 1, and the second voltage is greater than the first voltage; x first switching units receive a first control signal and are turned on under the control of the first control signal, so that x first storage units at the same level as the first switching unit that receives the first control signal are connected in series and discharge to form a first pulse, where x is an integer greater than or equal to 1 and less than or equal to n; y second switching units receive a second control signal and are turned on under the control of the second control signal, so that y second storage units at the same level as the second switching unit that receives the second control signal are connected in series and discharge to form a second pulse, y is an integer greater than or equal to 1 and less than or equal to m, a width of the second pulse is smaller than a width of the first pulse, and a time when the second pulse generating unit receives the second control signal is different from a time when the first pulse generating unit receives the first control signal; The first pulse and / or the second pulse are applied to a load.

Images