Cell image analysis system and slide storage method thereof

Abstract

The present invention provides a cell image analysis system and a slide storage method thereof, the system comprising: a first slide box for loading slides to be tested; a control device; a slide loading device, the control device controlling the slide loading device to load the slides to be tested in the first slide box onto a detection platform; a detection platform for carrying the slides to be tested for detection; an imaging device, the control device controlling the imaging device to photograph cells of samples in the slides to be tested on the detection platform, the slides to be tested that have completed the photographing being the tested slides; a slide unloading device, the control device controlling the slide unloading device to unload the tested slides from the detection platform into a second slide box; a second slide box for loading the tested slides, the capacity of the second slide box being greater than that of the first slide box. The system and method significantly reduce the number of times users frequently change slide boxes, avoid blockage of slides due to a full slide box, and greatly improve the storage efficiency of slides.

Description

[0001] This invention claims the application number 202010761483.2 filed on July 31, 2020, entitled “Cell Mapping The entire contents of the patent application are incorporated herein by reference. Technical Field

[0002] The present invention relates to the field of medical technology, and more particularly to slide storage. Background Art

[0003] When analyzing cell morphology, the cell image analysis device needs to place several slides in a temporary storage container (such as a slide basket) to achieve the transmission and delivery of the slides, thereby improving the efficiency and convenience of transmission. The slide basket carries several slides and transports the slide basket to the sampling channel of the cell image analysis device. The cell image analysis device clamps the slides one by one into the cell image analysis device for cell morphological analysis. The slides that have been inspected are returned to the slide basket, or placed in another slide basket, and then these slides that have been inspected are placed and stored together for subsequent reference.

[0004] However, current slide baskets have a limited capacity, and completed slides quickly fill the entire basket. This necessitates frequent removal of full baskets, which can cause the cell image analyzer to become blocked and shut down. Furthermore, the low storage density of the slides in the basket makes it unsuitable for long-term storage. Consequently, users must manually remove each slide and place them in a separate container that can hold multiple slides tightly. This frequent, time-consuming and labor-intensive operation is a daily necessity for operators. Delayed removal can also cause the slides to become blocked, halting the cell image analyzer.

[0005] Furthermore, existing slide recovery baskets are open only on one side, so slides must be placed in and removed from the basket from the same side. This makes cleaning the slides difficult, hinders usability, and creates a poor user experience. Furthermore, after analyzing blood smears, lens oil remains on the surface. Existing slide recovery baskets lack oil-blocking, oil-guiding, and oil-collecting functions, resulting in significant oil residue after long-term use, hindering reuse. Summary of the Invention

[0006] The embodiments of the present invention provide a cell image analysis system for repositioning a smear and a slide storage method thereof, so as to solve at least one of the above-mentioned problems.

[0007] According to a first aspect of the present invention, there is provided a cell image analysis system, the system comprising:

[0008] The first slide box is used to load the slides to be tested;

[0009] control devices;

[0010] a slide loading device, wherein the control device controls the slide loading device to load the slide to be tested in the first slide box onto the detection platform;

[0011] The detection platform is used to carry the glass slide to be tested for testing;

[0012] An imaging device, wherein the control device controls the imaging device to photograph the cells of the sample in the to-be-tested glass slide on the detection platform, and the to-be-tested glass slide that has completed photographing is referred to as a tested glass slide;

[0013] a slide unloading device, wherein the control device controls the slide unloading device to unload the tested slide from the detection platform into a second slide box;

[0014] The second slide box is used to load the tested slides, and the capacity of the second slide box is greater than that of the first slide box.

[0015] According to a second aspect of the present invention, there is provided a cell image analysis system, the system comprising:

[0016] control devices;

[0017] A slide loading device, used to load the slide to be tested onto the detection platform;

[0018] The detection platform is used to carry the glass slide to be tested for testing;

[0019] An imaging device is used to photograph the cells of the sample in the test slide on the detection platform, and the test slide that has completed the photographing is called the tested slide;

[0020] A slide unloading device, used for unloading the tested slides from the detection platform into a slide recovery box;

[0021] The recycling slide box is used to load the tested slides, and the recycling slide box is configured to accommodate at least 20, 40, 60, 80, or 100 slides.

[0022] According to a third aspect of the present invention, a slide storage method for a cell image analysis system is provided, the method comprising:

[0023] Sequentially obtain the slides to be tested from the first slide box and load them onto the detection platform;

[0024] Testing the sample in the test slide on the testing platform, and the test slide that has been tested is called the tested slide;

[0025] unloading the tested slide from the detection platform to a corresponding area among a plurality of preset areas of a second slide box according to the sample properties of the tested slide, wherein the plurality of preset areas are set by a user according to the sample properties;

[0026] The second slide cassette is loaded with measured slides from a plurality of the first slide cassettes.

[0027] According to the cell image analysis system and slide storage method of the embodiments of the present invention, by directly placing the tested slides into a large-capacity slide box for long-term storage, not only the number of times the user frequently replaces the slide box is greatly reduced, and the slide blockage caused by the full slide box is avoided, but also the large-capacity slide box is directly used for long-term storage, and the tested slides do not need to be manually transferred to the long-term storage container, which greatly improves the storage efficiency of the slides. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The above and other objects, features, and advantages of the present invention will become more apparent through a more detailed description of the embodiments of the present invention with reference to the accompanying drawings. The accompanying drawings are provided to provide a further understanding of the embodiments of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and are not intended to limit the present invention. In the drawings, the same reference numerals generally represent the same components or steps.

[0029] Figure 1a An example of a slide basket is shown;

[0030] Figure 1b An example of a slide storage container is shown;

[0031] Figure 2 is a schematic structural diagram of a cell image analysis system according to an embodiment of the present invention;

[0032] Figure 3a and Figure 3b is an example of a slide placement direction according to an embodiment of the present invention;

[0033] Figure 4 is a schematic structural diagram of a control device according to an embodiment of the present invention;

[0034] Figure 5a-5c is an example of a slide loading device according to an embodiment of the present invention;

[0035] Figure 6a-6c is an example of a slide loading device according to an embodiment of the present invention;

[0036] Figure 7 is another structural schematic diagram of a cell image analysis system according to an embodiment of the present invention;

[0037] Figure 8a-8cis an example of a slide unloading device according to an embodiment of the present invention;

[0038] Figure 9a-9c is an example of a slide unloading device according to an embodiment of the present invention;

[0039] Figure 10a-Figure 10d It is the storage method of the slides;

[0040] Figure 11a and Figure 11b is an example of a second slide box arranged in a single row according to an embodiment of the present invention;

[0041] Figure 12a and Figure 12b is an example of a second slide box arranged in a double row according to an embodiment of the present invention;

[0042] Figure 13 is an example of a second slide box arranged in three rows according to an embodiment of the present invention;

[0043] Figure 14a and Figure 14b is an example of a preset area of ​​a second slide box according to an embodiment of the present invention;

[0044] Figure 15a-Figure 15c is an example of slides arranged at intervals according to an embodiment of the present invention;

[0045] Figure 16 is an example of displaying a second slide box in a display component according to an embodiment of the present invention;

[0046] Figure 17 is a schematic perspective view of a second slide box according to an embodiment of the present invention as viewed from the left side;

[0047] Figure 18 yes Figure 17 A schematic perspective view of a second slide box viewed from the right side;

[0048] Figure 19 yes Figure 17 Another schematic perspective view of the second slide box viewed from the left side;

[0049] Figure 20 is a schematic perspective view of a receiving seat according to an embodiment of the present invention;

[0050] Figure 21 is a schematic perspective view of a side panel of a second slide box according to an embodiment of the present invention;

[0051] Figure 22 is a partial perspective view of a second slide box according to an embodiment of the present invention;

[0052] Figure 23Schematic diagram of the structure of a recovery slide box (single-row slot group) for storing tested sample slides in another embodiment of the present invention;

[0053] Figure 24 and 25 Schematic diagram of the structure of a recovery slide box (double-row slot group) for storing inspected slides in another embodiment of the present invention from different perspectives;

[0054] Figure 26 A schematic diagram of a sample slide placed obliquely in a slot in an embodiment of the present invention;

[0055] Figure 27 A schematic diagram of the positions of the readable unit and the guidance information in one embodiment of the present invention;

[0056] Figure 28 FIG. 4 is a schematic flow chart of a slide storage method of a cell image analysis system according to an embodiment of the present invention. DETAILED DESCRIPTION

[0057] In order to make the purpose, technical solutions and advantages of the present invention more apparent, exemplary embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments of the present invention, and it should be understood that the present invention is not limited to the exemplary embodiments described herein. Based on the embodiments of the present invention described in the present invention, all other embodiments obtained by those skilled in the art without creative work should fall within the scope of protection of the present invention.

[0058] In the current cell image analysis process, the slide basket used to store slides is generally small in volume and can only accommodate a few slides, such as Figure 1a As shown, Figure 1a An example of a slide basket is shown. Furthermore, to facilitate the machine's slide picking and placement operations, the spacing between slides is relatively large, resulting in a low density of slides that can be accommodated in the slide basket. If these existing slide baskets were used to store analyzed slides, users would need to frequently remove full baskets, otherwise the machine would become blocked and shut down, significantly reducing the efficiency of cell image analysis.

[0059] Based on the above considerations, a cell image analysis system is provided according to an embodiment of the present invention. Figure 2 , Figure 2 FIG. 1 shows a schematic diagram of the structure of a cell image analysis system according to an embodiment of the present invention. Figure 2 As shown, the system 200 includes:

[0060] The first slide box 210 is used to load the slides to be tested;

[0061] Control device 220;

[0062] A slide loading device 230 , wherein the control device 220 controls the slide loading device 230 to load the slides to be tested in the first slide box 210 onto the detection platform 240 ;

[0063] The detection platform 240 is used to carry the glass slide to be tested for testing;

[0064] An imaging device 250, wherein the control device 220 controls the imaging device 250 to photograph the cells of the sample in the to-be-tested glass slide on the detection platform, and the to-be-tested glass slide that has completed photographing is referred to as a tested glass slide;

[0065] a slide unloading device 260 , wherein the control device 220 controls the slide unloading device 260 to unload the tested slides from the detection platform into a second slide box 270 ;

[0066] The second slide box 270 is used to load the tested slides. The capacity of the second slide box 270 is greater than that of the first slide box 210 .

[0067] Among them, the cell image analysis system of the embodiment of the present invention directly places the tested slides into the second slide box with a capacity larger than the first slide box for storing the slides to be tested. The large-capacity second slide box can accommodate slides from multiple first slide boxes, and the user does not need to frequently replace the full second slide box. Compared with the traditional small-capacity slide basket, the number of times the user replaces the slide box is greatly reduced, which greatly improves the situation of machine operation blockage caused by insufficient slide box capacity, and also improves the inconvenience caused by frequent replacement of slide boxes.

[0068] In addition, traditional slide baskets are not suitable for long-term storage of slides due to their low storage density. In actual applications, medical institutions such as hospitals require archive backup of tested slides for periods ranging from two weeks to two years. If traditional slide baskets are used to store tested slides, a large amount of storage space will be required. Therefore, users are generally required to manually remove each slide one by one and place them in other slide storage containers that can hold multiple slides tightly, such as Figure 1b As shown, Figure 1b This process takes up a lot of time and energy of the user, and even a slight delay can cause the slides to get stuck and the machine to stop, which is even more detrimental to the storage of the measured slides.

[0069] However, in the cell image analysis system provided by the embodiments of the present invention, the second slide box can also be used directly as a storage container. This allows users to directly use the second slide box containing the measured slides for long-term storage, eliminating the need to manually move the measured slides to a long-term storage container. This significantly reduces user workload and error rates, preventing damage or loss of slides due to manual operation errors. Furthermore, using the second slide box directly for long-term storage also improves slide storage efficiency.

[0070] Therefore, the second slide box can be placed in the cell image analysis system as a temporary storage module for slides, and can also be taken out of the cell image analysis system as a long-term storage container for slides.

[0071] Optionally, the slides in the first slide box 210 and / or the second slide box 270 can be placed vertically or horizontally. Figure 3a and Figure 3b , Figure 3a and Figure 3b An example of a slide placement direction according to an embodiment of the present invention is shown. Figure 3a In the middle, the slide is placed vertically; Figure 3b In the experiment, the slides were placed horizontally.

[0072] In some embodiments, the first slide box 210 is configured to accommodate at least 10 slides.

[0073] It should be understood that the placement directions of the slides in the first slide box and the second slide box may be the same or different, and this is not limited here.

[0074] Alternatively, see Figure 4 , Figure 4 FIG. 1 shows a schematic diagram of the structure of a control device according to an embodiment of the present invention. Figure 4 As shown, the control device 220 includes at least: a processing component 431, RAM432, ROM433, a communication interface 434, a memory 436 and an I / O interface 435, wherein the processing component 431, RAM432, ROM433, the communication interface 434, the memory 436 and the I / O interface 435 can communicate through a bus 437.

[0075] The processing component 431 can be implemented by software, hardware, firmware or a combination thereof, and can use at least one of a circuit, a single or multiple application-specific integrated circuits (ASIC), a digital signal processor (DSP), a digital signal processing device (DSPD), a programmable logic device (PLD), a field programmable gate array (FPGA), a central processing unit (CPU), a controller, a microcontroller, and a microprocessor, so that the processing component 431 can execute some or all of the steps or any combination of the steps in the cell image analysis method and the slide storage method thereof in the various embodiments of the present application.

[0076] The memory 436 contains various computer programs such as an operating system and application programs for the processor component 431 to execute, as well as data required to execute the computer programs. In addition, during the sample testing process, any data that needs to be stored locally can be stored in the memory 436.

[0077] In some embodiments, memory 436 may be volatile memory or non-volatile memory, or may include both volatile and non-volatile memory. Non-volatile memory may include read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), ferromagnetic random access memory (FRAM), flash memory, magnetic surface memory, optical disk, or compact disc read-only memory (CD-ROM); magnetic surface memory may include magnetic disk storage or tape storage. Volatile memory may include random access memory (RAM), which is used as an external cache. By way of example and not limitation, many forms of RAM are available, such as static random access memory (SRAM), synchronous static random access memory (SSRAM), dynamic random access memory (DRAM), synchronous dynamic random access memory (SDRAM), double data rate synchronous dynamic random access memory (DDRSDRAM), enhanced synchronous dynamic random access memory (ESDRAM), synchronous link dynamic random access memory (SLDRAM), and direct rambus random access memory (DRRAM).The memory 436 described in the embodiments of the present invention is intended to include these and any other suitable types of memory.

[0078] I / O interface 435 is comprised of serial interfaces such as USB, IEEE1394, or RS-232C, parallel interfaces such as SCSI, IDE, or IEEE1284, and analog signal interfaces including D / A converters and A / D converters. Input devices such as a keyboard, mouse, trackball, click wheel, keys, buttons, touchpad, touch screen, or other control components are connected to I / O interface 435, allowing users to directly input data into control device 130. Furthermore, I / O interface 435 can also be connected to a display with display functionality, such as an LCD screen, touch screen, or LED display. Control device 220 can output processed data to the display as graphical display data, such as cell images, analysis data, and instrument operating parameters.

[0079] Communication interface 434 can be an interface using any communication protocol. Communication interface 434 communicates with the outside world via a network. Control device 220 can transmit data between any device connected to the network using a specific communication protocol via communication interface 434. It should be understood that the sample analysis system according to embodiments of the present invention is not limited by the communication interface. Whether it is an interface using currently known communication protocols or an interface using communication protocols developed in the future, it can be used in the cell image analysis system according to embodiments of the present invention to implement the function of communicating with the outside world via a network, and this is not limited here.

[0080] When the cell image analysis system according to an embodiment of the present invention is in operation, a corresponding operation interface can be provided for the operator to operate. The above operation interface can include various corresponding controls, such as an identification box or a menu bar, so that the operator can enter operation instructions on the operation interface according to actual usage to realize the analysis of cells on the sample slide through the cell image analysis system.

[0081] Optionally, the first slide box 210 and the second slide box 270 are respectively disposed on two sides of the imaging device 250 or the detection platform 240 .

[0082] In some embodiments, when the first slide box 210 and the second slide box 270 are arranged on both sides of the imaging device 250, the slide loading device 230 clamps the slide to be tested from the first slide box 210, moves and loads it onto the detection platform 240, and after being photographed by the imaging device 250, it is regarded as a tested slide and is clamped, moved and unloaded into the second slide box by the slide unloading device 260.

[0083] In some embodiments, when the first slide box 210 and the second slide box 270 are arranged on both sides of the detection platform 240, the slide loading device 230 clamps the slide to be tested from the first slide box 210 and loads it onto the detection platform 240. After being photographed by the imaging device 250, it is regarded as a tested slide and is clamped and unloaded by the slide unloading device 260 into the second slide box.

[0084] Optionally, the slide loader 230 can be connected to a transfer track to transport slides to be tested from other devices (such as slides to be tested prepared by a slide preparation device) to the cell image analysis system 200; the slide loader 230 may also not be connected to an external track, in which case the user can directly place the slide to be tested in the first slide box 210.

[0085] Optionally, the slide loading device 230 may include: a mechanical conveying part and a slide input module, wherein the mechanical conveying part automatically places the slide to be tested on the slide input module; and the slide input module loads the slide to be tested onto the detection platform.

[0086] The automatic loading of the slides to be tested by the mechanical conveyor can increase the processing speed of the system and reduce the workload of users (such as medical staff), while the slide input module can cache the slides to be tested.

[0087] In some embodiments, see Figure 5a , Figure 5a An example of a slide loading device according to an embodiment of the present invention is shown. Figure 5a In the embodiment, the slide loading device 530 includes: a mechanical conveying part 531 and a slide input module 532; wherein, the mechanical conveying part 531 can be implemented as a robotic arm, for example, which clamps the slide to be tested 533 upward from the vertically placed slides to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the slide input module 532.

[0088] In other embodiments, see Figure 5b , Figure 5b Still another example of the slide loading device according to the embodiment of the present invention is shown. Figure 5b In the embodiment, the slide loading device 530 includes: a mechanical conveying part 531 and a slide input module 532; wherein, the mechanical conveying part 531 can be implemented as a robotic arm, for example, which clamps the slide to be tested 533 out of the horizontally placed slides to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the slide input module 532.

[0089] It should be understood that in the above embodiment, when the distance between the first slide box and the slide input module is relatively close (for example, less than or equal to a preset value), and the robotic arm does not need to move horizontally and / or vertically to hold the slide, the robotic arm may also omit the horizontal and / or vertical movement and directly flip the vertically or horizontally placed slide to be tested onto the slide input module after gripping it.

[0090] In some embodiments, see Figure 5c , Figure 5c Still another example of the slide loading device according to the embodiment of the present invention is shown. Figure 5c In the embodiment, the mechanical conveying portion can also be implemented as a pushing device (not shown), which pushes or pulls the slide to be tested 533 directly horizontally from the slide to be tested horizontally placed in the first slide box to the slide input module 532.

[0091] In some embodiments, the slide input module 532 transfers the slide to be tested placed thereon to the detection platform. Further, the slide input module 532 can be used to transfer the slide to be tested to a position on the detection platform facing the imaging device via a transmission belt.

[0092] Alternatively, the slide loading device 230 may also include only a mechanical transport unit, thereby further improving detection efficiency and reducing the size of the cell image analysis system.

[0093] In some embodiments, see Figure 6a , Figure 6a An example of a slide loading device according to an embodiment of the present invention is shown. Figure 6a In the embodiment, the slide loading device 630 includes a mechanical conveying part 631, which can be implemented as a robotic arm. The robotic arm clamps the slide to be tested 632 upward from the vertically placed slide to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the detection platform.

[0094] In other embodiments, see Figure 6b , Figure 6b Another example of a slide loading device according to an embodiment of the present invention is shown. The robotic arm 631 clamps the slide to be tested 632 out of the horizontally placed slides to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the detection platform.

[0095] It should be understood that in the above embodiment, when the distance between the first slide box and the slide input module is relatively close (for example, less than or equal to a preset value), and the robotic arm does not need to move horizontally and / or vertically to hold the slide, the robotic arm may also omit the horizontal and / or vertical movement and directly flip the vertically or horizontally placed slide to be tested onto the slide input module after gripping it.

[0096] In some embodiments, see Figure 6c , Figure 6c Still another example of the slide loading device according to the embodiment of the present invention is shown. Figure 6c In the embodiment, the mechanical conveying portion can also be implemented as a pushing device (not shown), which pushes or pulls the slide 632 to be tested directly horizontally from the slides to be tested horizontally placed in the first slide box to the detection platform.

[0097] Optionally, the detection platform 240 may include:

[0098] The slide moving device 241 is used to move the slide relative to the imaging device 250 and fix the slide so that the imaging device 250 can capture cell images in a specific area of ​​the slide.

[0099] In some embodiments, the slide moving device may be provided with a fixing portion (eg, a clamp) for clamping the smear to maintain a stable position.

[0100] In some embodiments, the detection platform 240 may be located below the imaging device 250. When the slide device loads the slide to be tested onto the detection platform, the imaging device located above the detection platform may photograph the slide to obtain a cell image of the sample on the slide.

[0101] In some embodiments, the shape of the detection platform includes but is not limited to: square, circular. Wherein, a light hole is provided at the position where the glass slide is placed on the detection platform to ensure the brightness of the captured image.

[0102] Alternatively, as Figure 2 As shown, the imaging device 250 includes a lens group 251 and a camera 252, and is used to photograph cells in a sample smeared on a glass slide to obtain a cell image.

[0103] See also Figure 7 , Figure 7 FIG. 2 shows another structural diagram of a cell image analysis system according to an embodiment of the present invention. Figure 7 As shown, the imaging device 700 includes a camera 710 and a lens group 720, wherein the lens group 720 may include a first objective lens 720a, a second objective lens 720b and an adapter tube 720c. Optionally, the lens group 720 may further include an eyepiece (not shown). The first objective lens 720a may be, for example, a 10x objective lens, and the second objective lens 720b may be, for example, a 100x objective lens. The lens group 720 may further include a third objective lens 720d, which may be, for example, a 40x objective lens. The user may select an objective lens of any magnification to photograph the glass slide 731 to be tested, such as Figure 7As shown, a slide loading device (not shown) loads the slide to be tested in the first slide box 730 onto the detection platform, a slide moving device 740 on the detection platform moves the slide to be tested 731 into the field of view of the objective lens and fixes the slide to be tested, and an imaging device captures an image of the sample cells in the slide to be tested to obtain a cell image.

[0104] Optionally, the slide loading device 230 and the slide unloading device 260 may be different devices independent of each other.

[0105] Optionally, the slide unloading device 260 includes a mechanical conveyor unit and a slide output module. The mechanical conveyor unit automatically places the tested slides into the slide output module, and the slide output module unloads the tested slides into a second slide box. The slide output module can cache the tested slides.

[0106] In some embodiments, see Figure 8a , Figure 8a An example of a slide unloading apparatus according to an embodiment of the present invention is shown. Figure 8a In the embodiment, the slide unloading device 860 includes: a mechanical conveying part 861 and a slide output module 862; wherein, the mechanical conveying part 861 can be implemented as a robotic arm, for example, and the detection platform unloads the tested slide to the slide output module 862. The robotic arm clamps the tested slide 863 on the slide output module 862, moves it horizontally and / or vertically, and then flips it to place the tested slide vertically in the second slide box.

[0107] In other embodiments, see Figure 8b , Figure 8b Still another example of the slide unloading device according to the embodiment of the present invention is shown. Figure 8b In the embodiment, the slide unloading device 860 includes: a mechanical conveying part 861 and a slide input module 862; wherein, the mechanical conveying part 861 can be implemented as a robotic arm, for example, and the detection platform unloads the tested slide to the slide output module 862. The robotic arm clamps the tested slide 863 on the slide output module 862, moves it horizontally and / or vertically, and then flips it to place the tested slide horizontally in the second slide box.

[0108] It should be understood that in the above embodiment, when the distance between the second slide box and the slide output module is relatively close (for example, less than or equal to a predetermined value), and the robotic arm does not need to grip the slide and move horizontally, the robotic arm may also omit the horizontal and / or vertical movement and directly flip the gripped measured slide and place it vertically or horizontally in the second slide box.

[0109] In some embodiments, the inspection platform transfers the tested slide placed thereon to the slide output module 862. Furthermore, the inspection platform may be used to transfer the tested slide to the position of the slide output module 862 via a conveyor belt.

[0110] In some embodiments, see Figure 8c , Figure 8c Still another example of the slide unloading device according to the embodiment of the present invention is shown. Figure 8c In the embodiment, the mechanical conveying portion may also be implemented as a pushing device (not shown), which pushes the measured slides 863 on the slide input module 862 directly and horizontally into the second slide box.

[0111] Alternatively, the slide unloading device 260 may also include only a mechanical conveying unit, thereby further improving the slide unloading efficiency and reducing the size of the cell image analysis system.

[0112] In some embodiments, see Figure 9a , Figure 9a An example of a slide unloading apparatus according to an embodiment of the present invention is shown. Figure 9a In the embodiment, the slide unloading device 960 includes a mechanical conveying part 961, which can be implemented as a robotic arm. The robotic arm clamps the tested slide 963 on the detection platform, moves it horizontally and / or vertically, and then flips it to place the tested slide vertically in the second slide box.

[0113] In other embodiments, see Figure 9b , Figure 9b Another example of a slide unloading device according to an embodiment of the present invention is shown. The robotic arm 961 clamps the tested slide 962 on the detection platform, moves it horizontally and / or vertically, and then flips it to place the tested slide 963 horizontally in the second slide box.

[0114] It should be understood that in the above embodiment, when the distance between the second slide box and the slide output module is relatively close (for example, less than or equal to a predetermined value), and the robotic arm is not required to grip the slide and move horizontally and / or vertically, the robotic arm may also omit the horizontal and / or vertical movement and place the measured slide vertically or horizontally in the second slide box.

[0115] In some embodiments, see Figure 9c , Figure 9c Still another example of the slide unloading device according to the embodiment of the present invention is shown. Figure 9c In the embodiment, the mechanical conveying portion 961 can also be implemented as a pushing device, which pushes the slide to be tested 963 horizontally from the tested slide on the detection platform directly into the second slide box.

[0116] Figure 10a-Figure 10dShown is how the slides are stored. Figure 10a Shows a way to store slides in a vertical and upright position. Figure 10b Shows a horizontal positive storage slide method, Figure 10c Shows a way to store slides in a vertical sideways position. Figure 10d A method for storing slides in a horizontal or sideways position is shown; however, none of these methods allow for clear and intuitive viewing of slide labels. Therefore, it is very difficult to find the desired slide in a long-term slide storage container. Furthermore, to reduce the storage space occupied by the slides, the spacing between slides is very small, making it difficult to retrieve the slides with fingers. This can be difficult, or require multiple slides to be removed simultaneously and then selected from the desired slides, thus causing significant inconvenience to the user. According to an embodiment of the present invention, a second slide box is used as a long-term storage container, making it easier for users to find samples and store and manage them.

[0117] Optionally, the second slide box 270 includes: the second slide box includes a plurality of adjacent accommodating spaces of adjustable number, and the plurality of adjacent accommodating spaces are arranged in a single row or in multiple rows.

[0118] See also Figure 11a-Figure 11b , Figure 11a and Figure 11b FIG. 2 shows an example of a second slide box arranged in a single row according to an embodiment of the present invention. Figure 12a and Figure 12b , Figure 12a and Figure 12b An example of a second slide box with a double row arrangement according to an embodiment of the present invention is shown. Figure 13 , Figure 13 An example of a second slide cassette arranged in three rows according to an embodiment of the present invention is shown.

[0119] The spacing between slides in the second slide box is small, requiring only that the sample (blood film) on the slide be protected from scratching, thereby ensuring that as many slides as possible can be accommodated within a unit space. The capacity of the second slide box can be configured by the user to meet the needs of various practical applications. For example, different hospitals or users have different requirements, and the user can configure the second slide box's capacity to meet the needs of half a day, a day, a week, or other pre-set time periods.

[0120] In some embodiments, the capacity of the second slide box is at least five times the capacity of the first slide box. For example, when the first slide box is configured to accommodate 10 slides to be tested, the second slide box is configured to accommodate at least 50 tested slides. Furthermore, the second slide box may include 50 adjacent storage spaces arranged in a row, or may include 50 adjacent storage spaces arranged in two rows, with each row including 25 storage spaces.

[0121] In some embodiments, the second slide box is configured to accommodate at least 40, 60, 80, or 100 slides. For example, a second slide box arranged in a single row can be configured to accommodate 60 slides, or a second slide box arranged in a double row can be configured to accommodate 60 slides (30 slides per row).

[0122] Optionally, the second slide box is provided with a handheld device for holding, wherein the handheld device can be implemented as a handle provided on the outer wall of one side of the second slide box, making the second slide box easy to hold and transfer, convenient for users to take and put, and convenient for storing slides.

[0123] Optionally, an oil reservoir is provided in the second slide box, the oil reservoir being used to collect immersion oil from the measured slides in the second slide box. The oil reservoir can be provided at the bottom of the second slide box to prevent residual immersion oil on the slides from obstructing the removal and placement of the slides.

[0124] Optionally, the first slide box and the second slide box are respectively arranged on both sides of the imaging device or the detection platform.

[0125] Optionally, the second slide box is provided with an elastic device for fixing the tested slide placed in the second slide box. The elastic device can hold the slide in the accommodation space, so that the slide will not fall out of the accommodation space even if the second slide box is tilted or inverted.

[0126] Optionally, the second slide box 270 includes:

[0127] There are multiple preset areas that can be set, and the control device controls the slide unloading device to move the measured slides to the corresponding preset areas of the second slide box according to preset rules.

[0128] The user may set the capacity, location, quantity (number of preset areas), etc. of the preset areas as needed.

[0129] In some embodiments, the preset area can be set according to sample attributes, including: sample information, pathological information (such as disease type), patient characteristics, detection time or sample collection source (such as the department where the sample was collected).

[0130] In some embodiments, the preset rule includes: moving the measured glass slide to a preset area corresponding to the sample attribute of the measured glass slide.

[0131] See also Figure 14a and Figure 14b , Figure 14a and Figure 14b FIG2 shows an example of a preset area of ​​the second slide box according to an embodiment of the present invention. In some embodiments, the user can set the preset area in the second slide box according to the sample collection source in the slide, such as department, etc. Figure 14a As shown, Figure 14a There are 4 preset areas in the slide box: Area A, Area B, Area C, and Area D, which correspond to Department A, Department B, Department C, and other departments respectively. Then, after the slides in the first slide box are tested in sequence, the slides from Department A can be placed in Area A for storage, the slides from Department B can be placed in Area B for storage, the slides from Department C can be placed in Area C for storage, and the slides from other departments can be placed in Area D for storage. In this way, when the user searches for slides in the future, based on the search information, such as if the collection source is Department B, only the slides in Area B can be searched, which greatly improves the efficiency of searching for slides. Similarly, in some embodiments, such as Figure 14b As shown, Figure 14b There are three preset areas: area A, area B, and area C, and the capacity of area A is the sum of the capacities of area B and area C. It should be understood that the user can also set different preset areas according to other sample attributes, which is not limited here.

[0132] It should be noted that the above embodiment is only an example and is not intended to limit the second slide box to a double-row arrangement. Regardless of whether the second slide box is a single-row arrangement or a multi-row arrangement, it can be divided into several preset areas as needed.

[0133] In some embodiments, the preset rule further includes: determining the orientation of the measured slides when placed in the second slide box according to the orientation of the second slide box, and / or placing the measured slides in the second slide box at preset intervals.

[0134] Among them, when the measured slides are inserted into the second slide box, the label areas of the measured slides may block each other, making it inconvenient to find and take out the slides. Therefore, the user can insert the slides at intervals according to the needs, pull the slides apart, and conveniently view the label information of the slides. The way the slides are placed at intervals makes it easy for the user to take out the slides without affecting other slides. Figure 10a-Figure 10dWhen the control device controls the slide unloading device to unload the measured slides into the second slide box according to the slide placement direction shown in FIG, the direction of the second slide box can be determined first, and then the slide unloading device can be controlled to unload the measured slides into the second slide box according to the slide placement direction of the second slide box.

[0135] See also Figure 15a-Figure 15c , Figure 15a-Figure 15c An example of slides arranged at intervals according to an embodiment of the present invention is shown. Figure 15a In the second slide box, the tested slides are placed adjacent to each other without any gaps; Figure 15b In the second slide box, the measured slides are placed one slide apart; Figure 15c In the second slide box, the measured slides are placed two slides apart. It should be understood that the spacing between the slides in the second slide box can be set by the user as needed and is not limited here.

[0136] That is, the user can set at least one of the capacity, arrangement, preset area setting and slide placement method (including direction and / or spacing between slides) of the second slide box, which provides great flexibility for slide storage, can meet the needs of users in various occasions, and improve storage efficiency.

[0137] Optionally, the second slide box includes an identification portion, the identification portion includes a manual label and / or an electronic label, and the manual label and / or the electronic label are used to record characteristic information of the second slide box.

[0138] Among them, when the second slide box is directly used as a container for long-term storage of slides, in order to facilitate users to quickly find samples in the future, not only the information of the slide box itself can be marked on the second slide box, but also each measured slide stored in the slide box can be marked.

[0139] In some embodiments, each receiving space on the second slide box may be provided with a corresponding identifier (such as a number for each row and / or each column) to indicate the location of the receiving space, thereby facilitating quick positioning of stored slides.

[0140] In some embodiments, the second slide box includes a manual label on which the user can manually write information about the second slide box, such as a number (ID information), name, testing department, testing time, or testing personnel.

[0141] In some embodiments, the second slide box includes an electronic tag. The user can not only store information about the second slide box, such as the number (ID information), name, testing department, testing time, or testing personnel, in the electronic tag, but can also edit the electronic tag (such as an electronic chip, RFID) to record relevant information about the tested slide, facilitating rapid search and location of subsequent samples.

[0142] In some embodiments, the electronic tag is further used to record the index information, storage location information, sample characteristic information and / or sample test results of each of the tested slides in the second slide box.

[0143] Specifically, when a user needs to search for a certain measured slide in the storage, he can query in the corresponding storage system based on the known index information of the measured slide, such as the ID information of the slide itself, and obtain the number of the second slide box where the measured slide is located and the position of the measured slide in the slide box, so as to quickly locate the measured slide that needs to be found, which greatly facilitates the user's management and query of slides.

[0144] In some embodiments, the electronic tag may include a readable and writable RFID chip or other electronic device for recording or changing the ID information of the second slide box, and the user can locate and search for the stored slide sample based on the ID information.

[0145] In some embodiments, the information in the electronic tag can be repeatedly deleted and rewritten to record the characteristics and / or index information of the slides stored in the slide box.

[0146] Optionally, the system further comprises:

[0147] A storage device is used to store the characteristic information of the second slide box, and / or the index information, storage location information, sample characteristic information and / or sample test results of each of the tested slides in the second slide box.

[0148] The storage device may include a database system for storing the ID information of the second slide box and its corresponding location information, as well as the index information, storage location information, sample characteristic information, and / or sample test results of each slide in the second slide box. The storage device may also include retrieval software for retrieving the desired slide using the stored ID information of the second slide box or the index information of the slide, sample characteristic information, etc.

[0149] In some embodiments, after the image of the tested slide is captured on the testing platform, the imaging device obtains a cell image of the tested slide. The control device determines a specific storage location in a preset area where the tested slide is to be stored based on the sample attributes of the tested slide. The control device then controls the slide unloading device to unload the tested slide to the specific storage location. Simultaneously, the ID information of the tested slide, the cell image, the specific storage location in the second slide box, and the ID information of the second slide box can be stored in the storage device in association with each other. Furthermore, based on the ID information of the tested slide, all relevant information about the tested slide prior to testing can be stored in association with the cell image, the location information in the second slide box, and the ID information of the second slide box.

[0150] In some embodiments, when a user needs to find a tested slide P (i.e., knowing at least one index information S of the tested slide P), the user can retrieve the information S in the database system to obtain the location L of the tested slide P stored in the second slide box Q. The user can quickly locate the second slide box Q using the manual label on the second slide box Q, thereby finding the tested slide P. The user can also quickly locate the second slide box Q using the manual label on the second slide box Q, and then use a handheld reader to read the information of the loaded slides recorded on the electronic label in the second slide box Q to determine whether the specific location of the tested slide P is L, and then find the tested slide P based on the specific location. It should be understood that the user can set both manual labels and electronic labels simultaneously, combining the advantages of manual labels' intuitiveness and ease of search with the electronic labels' storage of sample information for each slide, thereby improving the storage, management, and query efficiency of slides.

[0151] Optionally, the system has a counting component for counting the number of the measured slides in the second slide box.

[0152] In some embodiments, the number of slides measured in the second slide box can be obtained by counting the number of slide ID information related to the second slide box in the storage device.

[0153] In some embodiments, the number of times the slide unloading device operates can be counted as the number of measured slides in the second slide box.

[0154] In some embodiments, by detecting whether each receiving space contains a slide, the number of receiving spaces containing slides can be counted as the number of measured slides in the second slide box. Furthermore, the position information or ID information of the receiving spaces containing slides can be counted to indicate the receiving spaces containing slides and the receiving spaces not containing slides.

[0155] Optionally, the system further comprises a prompting device for prompting a user to replace the second slide box when the number of the measured slides in at least one of the preset areas reaches a preset threshold.

[0156] In some embodiments, when the counting component counts that the number of accommodating spaces in a certain preset area where slides are placed reaches the number of accommodating spaces in the preset area, i.e., the preset area is full, the user may be prompted to replace the second slide box. Alternatively, in order to maximize the use of the second slide box for storing tested slides, the user may not be prompted temporarily when the preset area is full, because at this time, other preset areas may still be available for placement. If the next tested slide belongs to another preset area, it may continue to be placed in the other preset area. However, if the next tested slide still belongs to a preset area that is already full, the user may be prompted to replace the second slide box.

[0157] In some embodiments, the prompt device may use voice prompts and / or indicator light prompts, which are not limited here.

[0158] Optionally, the system further comprises a detection device for detecting whether the second slide box is placed in a predetermined position before the tested slide is loaded into the second slide box.

[0159] In some embodiments, the detection device includes a sensor, and the sensor can detect whether the second slide box is placed in a predetermined position.

[0160] Optionally, the prompting device is further configured to prompt the user that the second slide box has not been placed when the detecting device detects that the second slide box has not been placed in the predetermined position.

[0161] In some embodiments, when the cell image analysis system is turned on, or before or when the measured slides need to be unloaded to the second slide box, if it is detected that the second slide box is not placed in the predetermined position, the prompt device can use voice prompts, such as playing "the second slide box is not placed"; it can also use indicator lights to prompt, for example, the indicator light is on or flashing to indicate that the second slide box is not placed; voice and indicator lights can be used for prompts at the same time, and there is no limitation here.

[0162] Optionally, the system further comprises a display component for displaying the position of the second slide box where the measured slides have been loaded and / or the number of the measured slides in the second slide box.

[0163] In some embodiments, the display component may be a display screen. The display screen may display a distribution image of the second slide box, and use different colors to distinguish between the portion loaded with the measured slides and the portion not loaded with slides. Furthermore, the position information corresponding to each storage space may also be displayed simultaneously. Figure 16 , Figure 16 An example in which a second slide cassette is displayed in the display section according to an embodiment of the present invention is shown. Figure 16 In the embodiment, the second slide box can be divided into preset areas A, B, and C. A first color (e.g., green, not shown) and / or a first symbol (e.g., "○" or "√") can be used to indicate that a slide is already loaded in the storage space, while a second color (e.g., yellow, not shown) and / or a second symbol (e.g., "△" or "×" or no symbol) can be used to indicate that no slide is loaded in the storage space. Thus, in preset area A of the second slide box, row 1, column 1 and row 2, column 1 are loaded with tested slides, while in preset area B, row 1, column 2, row 2, column 2, and row 3, column 2 are loaded with tested slides. Furthermore, the number of slides loaded in the second slide box can be displayed, e.g., 5 slides loaded / capacity 20. The number of slides loaded in each preset area of ​​the second slide box can also be displayed separately, e.g., preset area A: 2 slides loaded / capacity 6, preset area B: 3 slides loaded / capacity 6, and preset area C: 0 slides loaded / capacity 8.

[0164] Optionally, the system further includes: an identification device 280 for identifying an electronic identification mark in the glass slide to be tested or the tested glass slide to obtain identity information of the glass slide to be tested or the tested glass slide.

[0165] In some embodiments, the electronic identification mark of the slide to be tested or the tested slide may include but is not limited to: a barcode and / or a radio frequency identification tag of the slide to be tested or the tested slide.

[0166] In some embodiments, the identity information of the slide to be tested or the tested slide may include but is not limited to: the number (ID) of the slide to be tested or the tested slide, and / or the source of the slide to be tested or the tested slide (e.g., which department it comes from, and / or which patient it comes from, etc.).

[0167] Specifically, the detection or analysis of the sample on the test slide can be performed based on the barcode or radio frequency identification tag on the test slide to obtain relevant information about the sample, such as patient information, operation information of the test slide, etc. In some embodiments, the relevant information about the sample includes but is not limited to: patient personal information and sample barcode information. The patient's personal information may include name, patient number, height, weight, etc.

[0168] According to an embodiment of the present invention, a cell image analysis system includes:

[0169] control devices;

[0170] A slide loading device, used to load the slide to be tested onto the detection platform;

[0171] The detection platform is used to carry the glass slide to be tested for testing;

[0172] An imaging device is used to photograph the cells of the sample in the test slide on the detection platform, and the test slide that has completed the photographing is called the tested slide;

[0173] A slide unloading device, used for unloading the tested slides from the detection platform into a slide recovery box;

[0174] The recycling slide box is used to load the tested slides, and the recycling slide box is configured to accommodate at least 20, 40, 60, 80, or 100 slides.

[0175] Optionally, the recovery slide box is set to multiple preset areas according to the sample attributes, and the control device controls the slide unloading device to move the tested slide to the preset area corresponding to the sample attributes of the tested slide; wherein the sample attributes include: sample information, pathological information, patient characteristics, detection time or sample collection source.

[0176] Optionally, the control device controls the slide unloading device to place a preset number of the measured slides into the recovery slide box.

[0177] Optionally, an elastic device is provided in the recycling slide box, and the elastic device is used to fix the tested slide placed in the recycling slide box.

[0178] Optionally, the recycling slide box includes an identification portion, which includes a manual label and / or an electronic label, and the manual label and / or the electronic label are used to record characteristic information of the recycling slide box; wherein, the electronic label is also used to record the index information, storage location information, and characteristic information of the sample and / or the test result of the sample of each tested slide in the recycling slide box.

[0179] Optionally, the system further comprises:

[0180] The storage device is used to store the characteristic information of the recycling slide box, and / or the index information and storage location information of each of the tested slides in the recycling slide box, as well as the characteristic information of the sample and / or the test result of the sample.

[0181] Optionally, the system further comprises:

[0182] a counting component for counting the number of the measured slides in the recycling slide box;

[0183] The display component is used to display the position of the measured slides in the recycling slide box and / or the number of the measured slides in the recycling slide box.

[0184] Optionally, the system further comprises a prompting device for prompting a user to replace the recycling slide box when the number of the measured slides in at least one of the preset areas reaches a preset threshold.

[0185] Optionally, the system further includes a detection device for detecting whether the recovery slide box is placed in a predetermined position before the tested slide is loaded into the recovery slide box, and when the detection device detects that the recovery slide box is not placed in the predetermined position, the prompting device prompts the user that the recovery slide box has not been placed.

[0186] It should be understood that the components included in the cell image analysis system shown above are only exemplary, and the system may include more or fewer components, which is not a limitation of the present invention.

[0187] Figures 17 to 19 A perspective view of a second slide box or a recycling slide box 270 is shown according to an embodiment of the present invention.

[0188] like Figure 17 and Figure 18 The recycling slide box 270 includes a housing 12 and a plurality of slots 114 disposed in the housing 12 for accommodating the slides 10. In the current embodiment, the recycling slide box 270 includes 60 slots or recycling storage slots 114, which can recycle and store 60 slides 10.

[0189] The housing 12 includes four side portions (i.e., two opposite left and right sides and two opposite front and back sides), a top and a bottom. Figure 17 and Figure 18 The first side plate 1110 and the second side plate 1120 are respectively provided on the first side plate 1110 and the second side plate 1120. Each slot 114 is formed by a first support portion 1141 on the first side plate 1110 and a second support portion 1142 on the second side plate 1120 opposite to the first support portion 1141.

[0190] The first side plate 1110 and the second side plate 1120 are, for example, detachably mounted on the inner sides of the corresponding first side portions 1210 of the housing 12. Of course, in other embodiments, the first side plate 1110 and the second side plate 1120 may also be integrated on the inner sides of the corresponding first side portions 1210 of the housing 12.

[0191] The housing 12 has openings on two opposing second sides (front and back) for the slides 10 to enter and exit the slot 114, namely a first opening 1220 and a second opening (not shown). This allows the second slide box, or recycling slide box 270, to communicate front to back, allowing recycled slides 10 to be inserted or removed from the front to the back, or from the back to the front. Having openings on both the front and back of the recycling slide box 270 makes it easier for users to find and clean slides.

[0192] In a preferred embodiment, the length of each recycling storage slot 114 is shorter than the length of the slide. Particularly preferably, the length of each recycling storage slot 114 is shorter than the length of the slide by the length of the label area (i.e., the area where the slide label information is printed). This ensures that the slide label information printing area is not covered by the slot, and that immersion oil dripped onto the slide does not contaminate the slide label information printing area, thereby preventing contamination of the user's hands when searching and viewing the slide.

[0193] In addition, a handle 121 is provided on the top 1230 of the housing 12 to facilitate users in taking out and placing the recycling slide box 270 .

[0194] Furthermore, if Figures 17 to 19 As shown, anti-slip recesses 122 are provided on both the left and right outer sides of the housing 12 (ie, the outer sides of the first side portion 1210 where the side panels are located) for users to take the recycling slide box 270 from the side.

[0195] When the slides are recovered, the recovery slide box 270 is accommodated in a receiving seat 3 provided in the cell image analysis system. Figure 20 As shown. Figure 19 and Figure 20 As shown, to facilitate placement of the recycling glass box 270 in the receiving seat 3, the recycling glass box 270 has a foolproof design. A foolproof guide groove 123 is provided on the outer side (here, the left outer side) of one of the first side portions 1210 of the housing 12. This guide groove cooperates with a guide bar 38 provided in the receiving seat 3 to guide the recycling glass box 270 into the receiving seat 3. Furthermore, recesses 124 are provided on either side of the guide groove 123. These recesses cooperate with a ball plunger 37 provided in the receiving seat to securely position the recycling glass box 270 in the receiving seat 3. This ensures that the recycling glass box 270 is accurately positioned in the receiving seat 3 and prevents user error.

[0196] Furthermore, if Figure 19 and Figure 20As shown, a fixing device 125 is provided at the bottom of the recycling glass slide box 270, and the fixing device 125 is used in conjunction with the suction device 32 provided in the bottom of the cavity of the accommodating seat 3. When the suction device 32 cooperates with the fixing device 125, the recycling glass slide box 270 is firmly fixed on the accommodating seat 3. At this time, the user cannot remove the recycling glass slide box 270 from the accommodating seat 3.

[0197] In addition, Figure 20 In the illustrated embodiment, the receiving seat 3 further includes an identification portion 33 for detecting whether the recycling slide box 270 is placed in the receiving seat 3 .

[0198] Lens oil often remains on analyzed slides. After repeated use of the recovery slide box for a period of time, a large amount of oil will remain in the box, causing oil pollution. In addition, users need to frequently change gloves, which increases costs. Therefore, the embodiments of the present invention provide a new oil guide and collection system.

[0199] In the oil guiding and concentrating system proposed in one embodiment of the present invention, at least one oil guiding groove 112 is provided in at least one of the first side plate 1110 and the second side plate 1120 of the housing. Figure 21 As shown, Figure 21 A perspective view of a first side plate 1110 according to an embodiment of the present invention is shown. An oil guide groove 112 is defined in the first side plate 1110 .

[0200] Preferably, at least one oil guide groove 112 is provided in each of the first side plate 1110 and the second side plate 1120. Further preferably, the oil guide grooves provided in the first side plate 1110 and the oil guide grooves provided in the second side plate 1120 are arranged asymmetrically to ensure smooth recovery of the slides into the slots 114.

[0201] Preferably, if Figure 21 As shown, all the slots 114 are penetrated from top to bottom by the oil guide groove 112, so that the immersion oil in the slots 114 is guided along the oil guide groove 112, especially to the bottom 1240 of the housing 12. In other words, the at least one oil guide groove 112 is configured to penetrate the support portion of each slot 114 located on the side plate where the at least one oil guide groove is located, for example, penetrate the support portion from the middle. For example, Figure 21 In the illustrated embodiment, the oil guide groove 112 defined in the first side plate 1110 extends through the first support portion 1141 of each slot 114 . If an oil guide groove is defined in the second side plate 1120 , the oil guide groove of the second side plate 1120 may extend through the second support portion 1142 of each slot 114 .

[0202] like Figure 21As shown, the oil guide groove 112 extends from at least the uppermost slot 114' among the plurality of slots, for example, vertically to near the bottom 1240 of the housing 12, and penetrates the first support portion 1141 of each slot 114. Preferably, the oil guide groove 112 extends obliquely (i.e., at an angle to the vertical direction) from at least the uppermost slot 114' among the plurality of slots to near the bottom 1240 of the housing 12, thereby allowing the slides to be smoothly recovered into the recovery slide box 270 without being stuck in the slots 114.

[0203] In some embodiments, at least one first oil guiding groove 111 is opened in at least one of the first side plate 1110 and the second side plate 1120, and at least one second oil guiding groove 112 is opened in at least one of the first side plate 1110 and the second side plate 1120. The at least one first oil guiding groove 111 extends near the side edge of the side plate where it is located and does not pass through the support portion of each slot, and the at least one second oil guiding groove 112 passes through the support portion of each slot in the side plate where it is located.

[0204] exist Figure 21 In the illustrated embodiment, a first oil-conducting groove 111 and a second oil-conducting groove 112 are defined in the first side plate 1110. The first oil-conducting groove 111 extends near the front edge of the first side plate 1110, in front of the slots 114. It begins at the underside of the top 1230 of the housing 12 and extends to near the bottom 1240 of the housing 12, specifically to the oil reservoir 127 provided in the bottom 1240 of the housing 12. The oil reservoir 127 receives oil discharged from the oil-conducting grooves 111 and 113 of the side plate, facilitating user cleaning. The second oil-conducting groove 112 extends from the uppermost slot 114' to near the bottom 1240 of the housing 12, specifically to the oil reservoir 127, and penetrates the first support portion 1141 of each slot 114.

[0205] Although Figure 21 Only the oil guide structure of the first side plate 1110 is shown, but it is understandable that the second side plate 1120 may also have the same or similar oil guide structure.

[0206] In addition, if Figure 21 As shown, the first side plate 1110 further includes a clamping portion 113, particularly an elastic clamping portion (e.g., a spring), for each slot 114, for laterally clamping a glass slide in the slot 114. This lateral clamping of the glass slide protects the blood film smeared on the upper side of the glass slide. It is understood that, corresponding to the first side plate 1110, the second side plate 1120 also includes a clamping portion 113 for laterally clamping a glass slide in the slot 114, corresponding to the first side plate 1110.

[0207] Preferably, the clamping portion 113 extends obliquely from the corresponding side panel toward the longitudinal axis of the slot 114. The inclined design of the lateral clamping portion, especially the large-angle design, can provide assistance when cleaning the glass slides in the recovery box 270, making it easier for the user to clean the glass slides. In other words, the inclined design of the lateral clamping portion can not only effectively provide side clamping force, but also provide front-to-back assistance when cleaning the glass slides in the recovery box 270 from front to back, making the cleaning of the glass slides smoother. In addition, after the user removes the recycling box from the receiving seat after recycling, the glass slides inside will not fall out even if the recycling box is turned upside down or tilted.

[0208] Figure 22 A preferred design of the elastic clamping portion 113 is shown. Each elastic clamping portion 113 extends obliquely from the corresponding side plate toward the longitudinal axis of the corresponding slot 114 , with an inclination angle of approximately 40°.

[0209] Further, if Figure 18 As shown, in order to facilitate the user to find the recycled glass slides, a label portion 128 is provided on the handle 121 for the user to distinguish different recycling boxes 270. In addition, an information storage and identification portion 126 is provided on the right side of the housing 12, which stores the situation of the recycled glass slides in the recycling box 270. Figure 20 As shown, an information identification module 36 (such as an RFID card reader) is provided on the side plate 31 of the receiving seat 3 , and the information identification module 36 is used in conjunction with the information storage identification unit 126 .

[0210] Thus, embodiments of the present invention provide a large-capacity glass slide recovery box that can prevent, guide, and collect oil, as well as quickly clean glass slides. Addressing the shortcomings of existing glass slide recovery boxes, such as small capacity, inconvenient slide retrieval and cleaning, and residual oil, embodiments of the present invention significantly enhance the usability of the glass slide recovery box through features such as an oil-guiding groove structure, dual openings (allowing slides to enter and exit in both directions), and a structure with large angles on both sides to hold the slides in place.

[0211] Figure 23 A perspective view of a second slide box or a recycling slide box 300 provided in another embodiment of the present invention is shown. The recycling slide box 300 includes a box body 310 and a slot assembly 320 disposed in the box body 310. The box body 310 has a accommodating cavity 311. One side of the accommodating cavity 311 is provided with an insertion port 312 for horizontally inserting and removing sample slides, and the other side surfaces and bottom surface of the accommodating cavity 311 are closed. The slot assembly 320 is disposed in the accommodating cavity 311, and the slot assembly 320 has at least one column of slot groups, each of which has at least two slots 321 for inserting sample slides 800. All the slots 321 in each column of the slot group are arranged horizontally and stacked in the vertical direction, and the entrances of the slots 321 are connected to the insertion port 312.

[0212] Efficacy oil is typically located in the center of the specimen slide 800. When a specimen slide 800, after testing, is moved to the recovery slide box 300, it can be inserted through the insertion port 312 into the corresponding slot 321, with the center portion being accommodated within the slot 321. Since the sides and bottom of the box body 310 are sealed except for the insertion port 312, even if liquid on the specimen slide 800 flows, most of it will flow into the chamber of the box body 310. This minimizes outflow, avoids contamination of other equipment and instruments, and reduces operator inconvenience.

[0213] Please refer to Figures 23 to 25 In one embodiment, the box body 310 includes a bottom shell 314, a top shell 315, and a side shell 313 connected between the bottom shell 314 and the top shell 315. The bottom shell 314, the top shell 315, and the side shell 313 form a receiving cavity 311, and the insertion opening 312 is located on one side of the side shell 313. The box body 310 can be generally square in shape. Three of the four sides of the box body 310 are closed, and only one side is used to provide the insertion opening 312.

[0214] Please refer to Figure 26 The side of the accommodating chamber 311 where the insertion opening 312 is located is the outer side, and the side opposite to the outer side is the inner side. In order to further reduce the outflow of liquids such as immersion oil, in one embodiment, the slot assembly 320 has a limiting structure, which forms a slide insertion channel on the slot 321 that is arranged obliquely downward from the outer side to the inner side, so that the sample slide 800 can be arranged obliquely downward from the outer side to the inner side in the slot 321. As shown in Figure 5, the sample slide 800 is inserted into the slot 321 from right to left. The left side of the drawing shows the front end 801 of the sample slide 800, which is located on the inner side of the accommodating chamber 311. The right side of the drawing shows the rear end 802 of the sample slide 800, which is located on the outer side of the accommodating chamber 311. At this time, the front end 801 of the sample slide 800 is lower than the rear end 802 thereof, thereby guiding the immersion oil and other liquids to flow toward the front end 801 thereof, thereby guiding more of the liquid to flow into the accommodating cavity 311 of the box body 310 rather than to the side of the insertion port 312 of the accommodating cavity 311, thereby further reducing the situation where the liquid flows out of the recovery slide box 300.

[0215] The slide insertion channel refers to the movable space within the box body 310 where the sample slide 800 is stored. That is, the sample slide 800 can only move within the slide insertion channel. The box body 310 has a slot 321. The slide insertion channel may include all or part of the slot 321. For example, a portion of the slot 321 and other components (such as the lower pressure member or upper push member described below) form a slide insertion channel for accommodating the sample slide 800.

[0216] In one embodiment, the restraining structure includes a pressing member 322 having a pressing portion 3221 for pressing down on the sample slide 800. The pressing portion 3221 is used to press down on one end of the sample slide 800 from above the sample slide 800, causing the sample slide 800 to be positioned obliquely downward from the outside to the inside in the slot 321. Typically, the pressing member 322 primarily presses downward on the front end 801 of the sample slide 800. However, in some embodiments, the pressing member 322 may also press on other locations on the sample slide 800, as long as the front end 801 of the sample slide 800 is lower than the rear end 802.

[0217] The pressing member 322 can be arranged inside the slot 321 or outside the slot 321. Referring to Figure 5, in one embodiment, the end of the slot 321 facing the insertion port 312 is an inlet, and the end of the slot 321 away from the inlet is an outlet, and the inlet and the outlet are arranged in a through-connected manner. The front end 801 of the sample slide 800 extends out of the outlet. The pressing portion 3221 is located outside the outlet, and is used to press down the portion of the sample slide 800 extending out of the outlet, that is, to press against the front end 801 of the sample slide 800. In this embodiment, due to the restrictive effect of the pressing member 322, the sample slide 800 can only move in a part of the space in the slot 321. This part of the space and the passage space defined by the pressing member 322 are one of the components of the slide insertion channel.

[0218] In this embodiment, the pressing portion 3221 is lower than the upper groove wall 323 of the corresponding slot 321 and higher than the lower groove wall 324 , ultimately defining a space in the slot 321 for the sample slide 800 to be tilted downward.

[0219] Please refer to Figure 26 In one embodiment, the pressing member 322 is tilted, wherein the end of the pressing member 322 facing the insertion opening 312 is a first end 3222, and the end of the pressing member 322 facing away from the insertion opening 312 is a second end 3223. The pressing portion 3221 is located at the second end 3223 of the pressing member 322. The first end 3222 of the pressing member 322 is higher than the second end 3223. Therefore, when the sample slide 800 is inserted, the pressing member 322 meets the first end 3222 of the sample slide 800 to form a guide opening that gradually narrows from right to left, facilitating the insertion of the sample slide 800 under the corresponding pressing member 322 and guiding the sample slide 800 to move toward the second end 3223 of the pressing member 322.

[0220] Of course, the aforementioned pressing member 322 is only one means of achieving the tilted placement of the sample slide 800. In another embodiment, the restraining structure includes an upper push member (not shown) that is used to lift one end of the sample slide 800 from below, allowing the sample slide 800 to be placed obliquely downward from the outside to the inside in the slot 321.

[0221] The upper push piece usually pushes up the rear end 802 of the sample slide 800. Of course, in some embodiments, the upper push piece can also be placed at other positions of the sample slide 800 as long as the front end 801 of the sample slide 800 is lower than the rear end 802 thereof.

[0222] The upper push member has an upper portion for lifting the sample slide 800. Similar to the lower pressing member 322, the upper push member can be disposed within the slot 321 or outside the slot 321. In one embodiment, the upper portion is located outside the slot 321 and is used to lift the portion of the sample slide 800 outside the slot 321, i.e., the rear end 802 of the sample slide 800.

[0223] The above-mentioned pressing member 322 and the upper push member can be installed on the slot assembly 320 or on the box body 310. The pressing member 322 and the upper push member can be used alone or in combination. The upper push member and the pressing member 322 can be arranged inside the slot 321 or outside the slot 321, or one of them can be arranged inside the slot 321 and the other can be arranged outside the slot 321.

[0224] In one embodiment, the upper push member and the lower pressure member 322 are partially or entirely made of an elastic material, so that the upper push member and the lower pressure member 322 have a certain degree of self-adaptive adjustment when contacting the sample slide 800, thereby avoiding hard contact between the upper push member and the lower pressure member 322 and the sample slide 800. Of course, in other embodiments, the upper push member and the lower pressure member 322 can also be made of a non-elastic material.

[0225] In another embodiment, the slot 321 includes an upper slot wall 323 and a lower slot wall 324, wherein at least the lower slot wall 324 is arranged obliquely downward from the outside to the inside to form a restraining structure. After the sample slide 800 is inserted into the slot 321, it is guided by gravity along the inclined surface of the lower slot wall 324, thereby causing the front end 801 of the sample slide 800 to be lower than the rear end 802.

[0226] In this embodiment, the upper groove wall 323 can be an inclined surface in the same direction as the lower groove wall 324. Of course, it can also be set horizontally, or even an inclined surface opposite to the lower groove wall 324 (with an opposite inclined direction). The shape of the upper groove wall 323 is not limited here.

[0227] In addition to the various structures described above, the limiting structure may also be other types of structures, so as to tilt the sample slide 800 and guide the liquid thereon to flow toward the front end 801 thereof.

[0228] For further information, please refer to Figure 26 and 27In one embodiment, the slots 321 include an upper slot wall 323 and a lower slot wall 324. The middle portions of the upper slot wall 323 and the lower slot wall 324 of all slots 321 in the same row are left open to connect all slots 321 in the same row. A restriction structure is located in the open space 325. This open space 325 facilitates the placement of the restriction structure and facilitates the flow of liquids such as immersion oil toward the bottom wall of the accommodating chamber 311, preventing excess liquid from remaining on the upper slot wall 323 and the lower slot wall 324. It also facilitates observation of the condition of the sample slide 800 in the slot 321.

[0229] On the other hand, in order to further reduce the outflow of liquids such as immersion oil out of the box body 310, please refer to Figure 6. In one embodiment, the accommodating cavity 311 has a liquid reservoir 317. The liquid reservoir 317 is used to collect liquid flowing down from the sample slide 800, further reducing the outflow of liquid out of the recovery slide box 300.

[0230] In one embodiment, the liquid storage tank 317 is disposed on the bottom wall of the accommodating chamber 311 , and the liquid collected from various locations in the accommodating chamber 311 eventually flows to the bottom wall of the accommodating chamber 311 and is temporarily stored in the liquid storage tank 317 .

[0231] In one embodiment, at least one liquid reservoir 317 is disposed beneath each row of slot groups. The liquid reservoir 317 may be in an inverted T-shape, with the vertical section 3171 of the inverted T-shaped reservoir 317 extending beneath the corresponding slot group, and the transverse section 3172 of the inverted T-shaped reservoir 317 located outside the slot group. When there are two or more slot groups, the transverse sections 3172 of the liquid reservoirs 317 of adjacent slot groups are interconnected, allowing liquid from all slot groups to be collected at the transverse section 3172 for subsequent processing.

[0232] exist Figure 27 In the embodiment, the liquid reservoir 317 is recessed in the bottom wall of the accommodating chamber 311. In other embodiments, the liquid reservoir 317 can also be formed by tilting the bottom wall. For example, the inner end of the bottom wall can be tilted to form a liquid reservoir 317 on the inner side of the accommodating chamber 311 together with the side surface of the box body 310.

[0233] Furthermore, the number of the slot groups can be flexibly set according to recycling requirements and space requirements. As shown in FIG1 , in one embodiment, the slot groups are one group. Figures 22 to 23 As shown, in one embodiment, the slot assembly 320 has at least two rows of slot groups, and all the slot groups are arranged side by side in the accommodating cavity 311 of the box body 310.

[0234] Furthermore, regardless of whether one or more than two slot groups are used. In one embodiment, the outer wall of the box body 310 has a readable unit 331 representing the identity information of the recovery slide box 300. The readable unit 331 is a series of components capable of transmitting identity information, such as a radio frequency identification tag, a QR code, a barcode, etc. The identity information can be unique. By identifying the readable unit 331, the identity of the current recovery slide box 300 can be recorded, and which sample slides 800 are placed in the recovery slide box 300 can be recorded. When a sample slide 800 needs to be queried later, it can be conveniently determined in which recovery slide box 300 it is based on the recorded information.

[0235] Of course, to more accurately determine the position of the sample slide 800, in one embodiment, the box body 310 or the slot assembly 320 is provided with guide information 322 for displaying the serial number of the slot 321. As shown in Figure 6, the guide information 322 is provided on the slot assembly 320. The guide information 322 can be numbers or other forms of information, as long as it can display the serial number of each slot 321. The guide information 322 can be provided for each slot 321 individually, or it can be provided every certain number of slots 321.

[0236] According to an embodiment of the present invention, a slide storage method for a cell image analysis system is also provided. Figure 28 , Figure 28 FIG. 5 is a schematic flow chart of a slide storage method of a cell image analysis system according to an embodiment of the present invention. Figure 28 As shown, the method 1700 includes:

[0237] Step S1710, sequentially obtaining the slides to be tested from the first slide box and loading them onto the detection platform;

[0238] Step S1720, testing the sample in the test slide on the testing platform, and the test slide that has been tested is called the tested slide;

[0239] Step S1730, unloading the tested slide from the detection platform to a corresponding area among a plurality of preset areas of a second slide box according to the sample properties of the tested slide, wherein the plurality of preset areas are set by the user according to the sample properties;

[0240] The second slide cassette is loaded with measured slides from a plurality of the first slide cassettes.

[0241] According to an embodiment of the present invention, in step S1730, unloading the tested slide from the detection platform to a corresponding area among a plurality of preset areas of the second slide box according to the sample properties of the tested slide includes:

[0242] Obtaining position information of corresponding areas of the sample properties of the measured slide in the plurality of preset areas;

[0243] The measured slides are moved to the corresponding area according to the position information, and the measured slides are placed in the second slide box at intervals of a preset number.

[0244] Among them, in order to facilitate users to find slides, according to an embodiment of the present invention, when the measured slides are unloaded into the second slide box, the slides can be classified according to the information associated with the samples on the slides and placed in different preset areas. Slides of the same type can be placed in the same preset area, which is convenient for the classification and long-term storage of slides and is also conducive to the search for samples.

[0245] In some embodiments, the preset area can be set according to sample attributes, including: sample information, pathological information (such as disease type), patient characteristics, detection time or sample collection source (such as the department where the sample was collected).

[0246] Specifically, after the imaging device photographs the glass slide, the control device determines the preset area to which the measured glass slide belongs and the specific position where the measured glass slide will be placed in the preset area based on the sample properties of the measured glass slide, and controls the glass slide unloading device to move the measured glass slide to the second glass slide box according to the specific position; as mentioned above, the interval between the measured glass slides placed in the second glass slide box can be set by the user. At this time, the glass slide unloading device determines the placement direction of the measured glass slide based on the direction of the second glass slide box, and unloads the measured glass slide into the second glass slide box according to the placement interval set by the user.

[0247] Optionally, at intervals of a preset time period or when the number of the measured slides in at least one of the preset areas in the second slide box reaches a preset threshold, the second slide box is replaced and directly used as a storage container.

[0248] Among them, if the capacity of the second slide box can meet the capacity of all tested slides within a period of time (such as a day), the user can choose to replace the second slide box only at a preset time or a fixed time (such as the end of work every day), and directly move it to a dedicated slide storage space for long-term storage. This not only saves the process of frequently replacing the second slide box when testing multiple first slide boxes, but also saves the process of transferring the tested slides in the second slide box to a long-term storage container, which greatly saves the user's workflow and improves the storage efficiency of the slides.

[0249] Optionally, the second slide box has an electronic label, and the method further comprises:

[0250] The characteristic information of the second slide box, the index information and storage location information of each of the tested slides in the second slide box, and the characteristic information of the sample and / or the test result of the sample are all stored in the electronic tag.

[0251] Optionally, the method further includes:

[0252] reading the electronic tag of the second slide box to obtain index information of each of the tested slides;

[0253] Searching the index information of each of the tested slides according to the index information of the slide to be checked to obtain the storage location information of the slide to be checked;

[0254] The slide to be checked is taken out from the second slide box according to the storage location information of the slide to be checked.

[0255] In some embodiments, the cell image analysis system according to an embodiment of the present invention describes the working process of its slide storage.

[0256] The user performs cell image analysis on the slides to be tested in different first slide boxes at different times. Assume that the user tests a number of slides to be tested in the first slide box with a capacity of C1 in one day.

[0257] First, the user starts the cell image analysis system, which can detect whether the second slide box is in the predetermined position. If the second slide box is not in the predetermined position, the user is prompted. If the second slide box is already in the predetermined position, the system starts to detect each slide.

[0258] Then, for each first slide box, the user issues a detection instruction through the operating system;

[0259] Then, after receiving the detection instruction, the control device controls the robotic arm in the slide loading device to sequentially pick up the slides to be tested from the first slide box located on one side of the imaging device or the detection platform, and can directly load the slides to be tested (or indirectly load them through the slide input module) onto the detection platform through at least one of horizontal movement, vertical movement, and flipping. At the same time, the recognition module can recognize the electronic identification mark on the slide to be tested to obtain the identity information of the slide to be tested (such as the ID information of the slide);

[0260] Next, the imaging device located above the detection platform takes a picture of the cells in a specific area of ​​the test slide according to the shooting conditions set by the user, and obtains a cell image of the test slide. The test slide that has been photographed is recorded as a tested slide.

[0261] Next, the control device determines which preset area in the second slide box the sample to be tested should belong to and which accommodation space, i.e., specific storage location, the sample to be tested should be placed in based on the sample properties of the slide to be tested;

[0262] Next, the control device controls the robotic arm in the slide unloading device to directly unload (or indirectly unload through the slide output module) the tested slides on the testing platform to a specific storage location in a corresponding preset area in the second slide box with a capacity of C2 according to the specific storage location;

[0263] Next, the identity information of the tested slide, the captured cell image, the detection time, the ID information of the second slide box, and the specific location information of the tested slide in the second slide box can be stored in a storage device in an associated manner. At the same time, the technical unit in the system increases the number of the tested slides in the second slide box by 1, and the area corresponding to the tested slide in the schematic diagram of the second slide box displayed by the display component changes from the second symbol to the first mark to indicate that the tested slide is loaded in the area.

[0264] Next, if the counting unit detects that the second slide box is full of tested slides, the prompting device prompts the user to replace the second slide box; the user can hold the handle provided on one side of the second slide box filled with tested slides, remove the second slide box from the cell image analysis system, and directly place the second slide box in a dedicated storage area for long-term storage of the tested slides; wherein, if the capacity of the second slide box C2 ≥ C1 * a, that is, the second slide box can meet the number of test slides in a day, then, regardless of whether the second slide box is full, the user can replace the second slide box after completing the test on the same day and use the removed second slide box as a long-term storage container;

[0265] Then, when the user needs to retest one or more tested slides, the user can search the index information of all second slide boxes in the database based on the relevant information of the tested slide, that is, the ID information of the second slide box where the tested slide is located, the storage location of the second slide box, and the storage location of the tested slide in the second slide box can be obtained, so that the tested slide can be found directly and accurately.

[0266] An embodiment of the present invention also provides a computer-readable storage medium, which stores multiple program instructions. After the multiple program instructions are called and executed by a processor, some or all of the steps or any combination of the steps in the cell image analysis and slide storage methods in each embodiment of the present application can be executed.

[0267] In exemplary embodiments, embodiments of the present invention further provide a computer-readable storage medium, such as a memory device including a computer program. The computer program can be executed by a processor of a cell image analysis system to perform the steps of the aforementioned method. The computer-readable storage medium can be a memory device such as FRAM, ROM, PROM, EPROM, EEPROM, Flash Memory, magnetic surface mount storage, optical disk, or CD-ROM. It can also be various devices including any one or any combination of the aforementioned memory devices, such as a portable analyzer.

[0268] In summary, according to the cell image analysis system and slide storage method of the embodiments of the present invention, by directly placing the tested slides into a large-capacity slide box for long-term storage, not only the number of times the user frequently replaces the slide box is greatly reduced, and the slide blockage caused by the full slide box is avoided, but also the large-capacity slide box is directly used for long-term storage, and the tested slides do not need to be manually transferred to the long-term storage container, which greatly improves the storage efficiency of the slides.

[0269] Those skilled in the art will appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professionals and technicians can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of the present invention.

[0270] In the several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the division of the units described is merely a logical function division. In actual implementation, other division methods may be used, such as combining or integrating multiple units or components into another device, or ignoring or not performing some features.

[0271] In the description provided herein, numerous specific details are described. However, it is understood that embodiments of the present invention may be practiced without these specific details. In some instances, well-known methods, structures, and techniques are not shown in detail so as not to obscure the understanding of this description.

[0272] Similarly, it should be understood that in order to streamline the present invention and aid in understanding one or more of the various inventive aspects, in the description of exemplary embodiments of the present invention, the various features of the present invention are sometimes grouped together into a single embodiment, figure, or description thereof. However, this approach to the present invention should not be interpreted as reflecting the intention that the claimed invention requires more features than those explicitly recited in each claim. More precisely, as reflected in the corresponding claims, the inventive point is that the corresponding technical problem can be solved with fewer features than all the features of a single disclosed embodiment. Therefore, the claims following the detailed description are hereby expressly incorporated into the detailed description, with each claim itself serving as a separate embodiment of the present invention.

[0273] It will be understood by those skilled in the art that, except where mutually exclusive, all features disclosed in this specification (including the accompanying claims, abstract, and drawings) and all processes or units of any method or apparatus disclosed herein may be combined in any combination. Unless expressly stated otherwise, each feature disclosed in this specification (including the accompanying claims, abstract, and drawings) may be replaced by an alternative feature providing the same, equivalent, or similar purpose.

[0274] Furthermore, those skilled in the art will appreciate that although some embodiments described herein include certain features included in other embodiments but not other features, combinations of features from different embodiments are intended to be within the scope of the present invention and to form different embodiments. For example, in the claims, any of the claimed embodiments may be used in any combination.

[0275] It should be noted that the above embodiments illustrate rather than limit the invention, and that those skilled in the art may devise alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between brackets should not be construed as limiting the claims. The word "comprising" does not exclude the presence of elements or steps not listed in the claims. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The present invention may be implemented by means of hardware comprising several different elements and by means of appropriately programmed computers. In a unit claim enumerating several means, several of these means may be embodied by the same item of hardware. The use of the words first, second, and third etc. does not indicate any order. These words may be interpreted as names.

[0276] The foregoing description is merely a specific embodiment of the present invention or an illustration of a specific embodiment. The scope of protection of the present invention is not limited thereto. Any modifications or substitutions that can be readily conceived by a person skilled in the art within the technical scope disclosed in the present invention are intended to be encompassed by the scope of protection of the present invention. The scope of protection of the present invention shall be subject to the scope of protection of the claims.

Claims

1. A cell image analysis system, characterized in that: The system comprises: The first slide box is used to load the slides to be tested; control devices; a slide loading device, wherein the control device controls the slide loading device to load the slide to be tested in the first slide box onto the detection platform; The detection platform is used to carry the glass slide to be tested for testing; An imaging device, wherein the control device controls the imaging device to photograph the cells of the sample in the to-be-tested glass slide on the detection platform, and the to-be-tested glass slide that has completed photographing is referred to as a tested glass slide; a slide unloading device, wherein the control device controls the slide unloading device to unload the tested slide from the detection platform into a second slide box; The second slide box is used to load the tested slides. The capacity of the second slide box is greater than that of the first slide box. The second slide box includes a plurality of configurable preset areas. The control device controls the slide unloading device to move the tested slides to the corresponding preset areas of the second slide box according to preset rules.

2. The system according to claim 1, wherein: Setting the preset area according to sample attributes, wherein the sample attributes include: sample information, pathological information, patient characteristics, detection time or sample collection source; The preset rule includes: moving the measured glass slide to a preset area corresponding to the sample attribute of the measured glass slide.

3. The system according to claim 2, characterized in that The preset rule further includes: determining the direction of the measured slides when they are placed in the second slide box according to the direction of the second slide box, and / or placing the measured slides in the second slide box at intervals of a preset number.

4. The system according to any one of claims 1 to 3, characterized in that The first slide box and the second slide box are respectively arranged on both sides of the imaging device or the detection platform.

5. The system according to any one of claims 1 to 3, characterized in that The second slide box is provided with an elastic device, and the elastic device is used to fix the measured slide placed in the second slide box.

6. The system according to any one of claims 1 to 3, characterized in that The second slide box includes an identification portion, and the identification portion includes a manual label and / or an electronic label. The manual label and / or the electronic label are used to record characteristic information of the second slide box.

7. The system according to claim 6, characterized in that The electronic tag is further used to record the index information, storage location information, sample characteristic information and / or sample test results of each of the tested slides in the second slide box.

8. The system according to any one of claims 1 to 3, characterized in that The system further comprises: A storage device is used to store the characteristic information of the second slide box, and / or the index information, storage location information, sample characteristic information and / or sample test results of each of the tested slides in the second slide box.

9. The system according to any one of claims 1 to 3, characterized in that The second slide box is provided with a handheld device for holding.

10. The system according to any one of claims 1 to 3, characterized in that An oil storage device is provided in the second slide box, and the oil storage device is used to collect the immersion oil of the measured slides in the second slide box.

11. The system according to any one of claims 1 to 3, characterized in that The system comprises a counting component for counting the number of the measured slides in the second slide box; The system further comprises a display component for displaying the position of the second slide box where the measured slides have been loaded and / or the number of the measured slides in the second slide box.

12. The system according to any one of claims 1 to 3, characterized in that The system further includes a prompting device for prompting a user to replace the second slide box when the number of the measured slides in at least one of the preset areas reaches a preset threshold.

13. The system according to claim 12, wherein: The system further includes a detection device for detecting whether the second slide box is placed in a predetermined position before the tested slide is loaded into the second slide box. When the detection device detects that the second slide box is not placed in the predetermined position, the prompting device prompts the user that the second slide box has not been placed.

14. The system according to any one of claims 1 to 3, characterized in that The slide loading device and the slide unloading device are different devices independent of each other.

15. The system according to any one of claims 1 to 3, characterized in that The second slide box includes a plurality of adjacent accommodating spaces of adjustable number, and the plurality of adjacent accommodating spaces are arranged in a single row or in multiple rows.

16. The system according to any one of claims 1 to 3, characterized in that The capacity of the second slide box is at least 5 times the capacity of the first slide box; and / or The second slide box is configured to accommodate at least 40 slides; and / or The first slide box is configured to accommodate at least 10 slides.

17. The system according to any one of claims 1 to 3, characterized in that The second slide box has a shell and a plurality of slots arranged in the shell for accommodating slides. The shell has a first side panel and a second side panel on two opposite first side panels, and each slot is formed by a first supporting portion on the first side panel and a second supporting portion on the second side panel opposite to the first supporting portion.

18. The system according to claim 17, wherein: At least one oil guide groove is formed in at least one of the first side plate and the second side plate.

19. The system according to claim 18, wherein: At least one oil guide groove extends from at least an uppermost slot among the plurality of slots to near the bottom of the housing.

20. The system according to claim 19, wherein: At least one oil guide groove extends obliquely from at least an uppermost slot among the plurality of slots to near the bottom of the housing.

21. The system according to claim 18, wherein: At least one oil guide groove passes through the supporting portion of each slot located on the side plate where the at least one oil guide groove is located.

22. The system according to claim 18, wherein: At least one first oil guide groove is provided in at least one of the first side plate and the second side plate, and at least one second oil guide groove is provided in at least one of the first side plate and the second side plate. The at least one first oil guide groove extends in the side edge of the side plate where it is located and does not pass through the supporting portion of each slot, and the at least one second oil guide groove passes through the supporting portion of each slot in the side plate where it is located.

23. The system according to claim 18, wherein: At least one first oil guiding groove is formed in the first side plate, and at least one second oil guiding groove is formed in the second side plate. The at least one first oil guiding groove and the at least one second oil guiding groove are arranged asymmetrically.

24. The system according to claim 18, wherein: The length of each slot is less than the length of the slide.

25. The system according to claim 24, wherein: The length of each slot is shorter than the length of the slide by at least the length of the label area of ​​the slide.

26. The system according to claim 17, wherein: The shell is provided with openings on two opposite second side portions for slides to enter and exit the slots.

27. The system according to claim 17, wherein: A lateral clamping portion is provided on the first side plate and the second side plate for each slot, respectively, and the lateral clamping portion is used to clamp the smear in the slot from the side of the smear.

28. The system according to claim 27, wherein: Each lateral clamping portion extends obliquely from the corresponding side plate toward the longitudinal axis of the corresponding slot, with an inclination angle of 40°.

29. A cell image analysis system, characterized in that: The system comprises: control devices; A slide loading device, used to load the slide to be tested onto the detection platform; The detection platform is used to carry the glass slide to be tested for testing; An imaging device is used to photograph the cells of the sample in the test slide on the detection platform, and the test slide that has completed the photographing is called the tested slide; A slide unloading device, used for unloading the tested slides from the detection platform into a slide recovery box; The recycling slide box is used to load the tested slides, and the recycling slide box is constructed to accommodate at least 20 slides. The recycling slide box is set to multiple preset areas according to sample attributes. The control device controls the slide unloading device to move the tested slides to the preset areas corresponding to the sample attributes of the tested slides; wherein the sample attributes include: sample information, pathological information, patient characteristics, detection time or sample collection source.

30. The system according to claim 29, wherein: The control device controls the slide unloading device to place the measured slides into the recovery slide box at intervals of a preset number.

31. The system according to any one of claims 29-30, characterized in that The recycling slide box is provided with an elastic device, and the elastic device is used to fix the measured slide placed in the recycling slide box.

32. The system according to any one of claims 29-30, characterized in that The recycling slide box includes an identification portion, which includes a manual label and / or an electronic label. The manual label and / or the electronic label are used to record characteristic information of the recycling slide box; wherein the electronic label is also used to record the index information, storage location information, and characteristic information of the sample and / or the test result of each tested slide in the recycling slide box.

33. The system according to any one of claims 29-30, characterized in that The system further comprises: The storage device is used to store the characteristic information of the recycling slide box, and / or the index information and storage location information of each of the tested slides in the recycling slide box, as well as the characteristic information of the sample and / or the test result of the sample.

34. The system according to any one of claims 29-30, characterized in that The system further comprises: a counting component for counting the number of the measured slides in the recycling slide box; The display component is used to display the position of the measured slides in the recycling slide box and / or the number of the measured slides in the recycling slide box.

35. The system according to any one of claims 29-30, characterized in that The system further includes a prompting device for prompting a user to replace the recycling slide box when the number of the measured slides in at least one of the preset areas reaches a preset threshold.

36. The system according to claim 35, wherein: The system further includes a detection device for detecting whether the recovery slide box is placed in a predetermined position before the tested slide is loaded into the recovery slide box, and when the detection device detects that the recovery slide box is not placed in the predetermined position, the prompting device prompts the user that the recovery slide box has not been placed.

37. A slide storage method for a cell image analysis system, characterized in that: The method comprises: Sequentially obtain the slides to be tested from the first slide box and load them onto the detection platform; Testing the sample in the test slide on the testing platform, and the test slide that has been tested is called the tested slide; unloading the tested slide from the detection platform to a corresponding area among a plurality of preset areas of a second slide box according to the sample properties of the tested slide, wherein the plurality of preset areas are set by a user according to the sample properties; The second slide cassette is loaded with measured slides from a plurality of the first slide cassettes.

38. The method according to claim 37, wherein Unloading the tested slide from the detection platform to a corresponding area among a plurality of preset areas of a second slide box according to the sample properties of the tested slide comprises: Obtaining position information of corresponding areas of the sample properties of the measured slide in the plurality of preset areas; The measured slides are moved to the corresponding area according to the position information, and the measured slides are placed in the second slide box at intervals of a preset number.

39. The method according to any one of claims 37-38, characterized in that At intervals of a preset time period or when the number of the measured slides in at least one of the preset areas in the second slide box reaches a preset threshold, the second slide box is replaced and used directly as a storage container.

40. The method according to any one of claims 37-38, characterized in that The second slide box has an electronic label, and the method further includes: The characteristic information of the second slide box, the index information and storage location information of each of the tested slides in the second slide box, and the characteristic information of the sample and / or the test result of the sample are all stored in the electronic tag.

41. The method according to claim 40, wherein The method further comprises: reading the electronic tag of the second slide box to obtain index information of each of the tested slides; Searching the index information of each of the tested slides according to the index information of the slide to be checked to obtain the storage location information of the slide to be checked; The slide to be checked is taken out from the second slide box according to the storage location information of the slide to be checked.

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