Modified adenovirus

By designing adenovirus vectors, using the E4 gene and payload nucleic acid sequences missing from the adenovirus skeleton, the problem of identifying the best therapeutic antigens in existing antigen vaccines has been solved, and an efficient immune response and improved vaccine efficacy has been achieved.

CN114072516BActive Publication Date: 2025-01-14SEATTLE PROJECT CORP
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Patent Information

Application Number
CN202080047889.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2019-05-30
Filing Date
2020-06-01
Publication Date
2025-01-14
Estimated Expiration
2040-06-01

AI Technical Summary

Technical Problem

In existing antigen vaccine designs, it is difficult to effectively identify and utilize the best therapeutic antigens that induce immune responses, especially in human diseases, especially because of the pre-existing immunity of humans to human viruses, which limits the recombinant human virus as a vector. Application.

Method used

Develop an adenovirus vector containing the E4 gene of the adenovirus skeleton deletion, combining payload nucleic acid sequences encoding MHC class I and class II epitopes or antigens capable of stimulating B-cell responses, enhancing the virus through specific promoter and linker sequences production and immune response.

Benefits of technology

It significantly improves the production efficiency and immune response effect of viral vectors, enhances the presentation and recognition of specific antigens, and improves the efficacy of vaccines.

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Abstract

Disclosed herein are compositions comprising modified adenoviruses. Also disclosed are nucleotides, cells and methods related to the compositions, including their use as vaccines. Also disclosed herein are viral vectors using a TET promoter system and methods for producing viruses having the vectors.
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Citation Information

Patent Citations

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