Doxycycline microtablets and a method for preparing the same

Digoxin microtablets were prepared using spray drying and hot melt extrusion technology, which solved the problems of large tablet size and low dissolution of digoxin, and achieved precise dosage and improved bioavailability, thus meeting the medication needs of different patients.

CN114177152BActive Publication Date: 2026-07-07BEIJING VAGARY PHARM TECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING VAGARY PHARM TECH LTD
Filing Date
2021-12-16
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

The existing digoxin tablets are large in size, have low dissolution, which affects the therapeutic effect. They also have a low therapeutic index, a narrow safety range, large individual differences, and are prone to interactions when used in combination with other drugs, making it difficult to meet the medication needs of different patients.

Method used

Digoxin microtablets were prepared using spray drying and hot melt extrusion technology. Digoxin was mixed with excipients by spray drying to prepare a solid dispersion. The specifications and composition of the digoxin microtablets were optimized, and small-sized tablets were used to meet the medication needs of different patients.

Benefits of technology

It achieves precise dosage, improves dissolution and bioavailability, reduces production costs, meets the medication needs of patients of different ages, and reduces medication risks.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides a digoxin microtablet and a preparation method thereof. The digoxin microtablet prepared by the application contains 5-100 micrograms of digoxin per tablet, which can meet the dosage requirements of patients of different ages, realize precise dosage administration, and reduce the risk of drug overdose in clinical application. The digoxin microtablet provided by the application can solve the problem that infants and children have difficulty in swallowing the medicine, thereby improving the medication compliance of infants and children. Compared with conventional tablets, the microtablet has a smaller volume. The digoxin microtablet provided by the application is prepared by optimizing the prescription and process, preparing a digoxin compound by a spray drying and hot melt extrusion technology, obtaining a solid dispersion, and having better content uniformity and dissolution rate, and significantly improving the bioavailability.
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