An integrated fiber optic device for in-situ tumor detection and photothermal therapy

Abstract

This invention discloses an integrated fiber optic device for in-situ tumor detection and photothermal therapy, comprising an optical fiber, a tumor biomarker sensor, and a photothermal photosensitizer. The optical fiber includes a front end for contacting a solid tumor, enabling the tumor biomarker sensor to identify the tumor and the photothermal photosensitizer to thermally ablate it. This invention places the front end of the integrated fiber optic device for in-situ tumor detection and photothermal therapy close to the tumor location, thereby achieving tumor ablation through the photothermal photosensitizer and tumor biomarker sensor, ensuring immediate information feedback and security.

Description

Technical Field

[0001] This invention relates to the field of tumor optical diagnosis and treatment technology, and in particular to an integrated fiber optic device for in situ tumor detection and photothermal therapy. Background Technology

[0002] According to the World Health Organization, cancer accounts for one-sixth of all deaths, making it the second leading cause of death globally. In my country, the incidence of cancer is rising year by year, increasing at a rate of 10% annually. Advanced cancer diagnosis and treatment technologies are one of the key factors in ultimately defeating cancer.

[0003] With the continuous advancement of optical technology and nanomedicine research, optical tumor therapy technology is also developing rapidly. However, because human tissues generally absorb and scatter light significantly, the effective penetration depth of light energy into human tissues is often only a few millimeters, which is insufficient for treating tumors deep within the body and those affecting internal organs. Furthermore, although photosensitive nanomedicines have seen rapid development in recent years, concerns about their biosafety remain due to the incomplete understanding of the interaction mechanisms between injected nanomedicines and organs and tumors, limiting their clinical application. Therefore, in the field of tumor treatment, surgical resection and radiotherapy / chemotherapy remain the conventional methods. In the early stages of tumors, due to insufficient diagnostic certainty, patients often resist conventional treatment plans; in addition, a significant number of patients, at the time of diagnosis, have poor tolerance to surgery and radiotherapy / chemotherapy due to the characteristics of the tumor and the underlying organ lesions. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, the purpose of this invention is to provide an integrated fiber optic device for in situ tumor detection and photothermal therapy.

[0005] To achieve the above objectives, the present invention provides the following solution:

[0006] An integrated fiber optic device for in situ tumor detection and photothermal therapy includes: an optical fiber, a tumor biomarker sensor, and a photothermal photosensitizer;

[0007] The optical fiber includes a front end; the front end is internally disposed of the photothermal photosensitizer; the photothermal photosensitizer is used to receive heating light and generate heat according to the heating light to raise the temperature of the front end; the surface of the front end is disposed of the tumor feature marker sensor; the front end is used to contact a solid tumor to realize the tumor feature marker sensor's identification of the tumor and the photothermal photosensitizer's thermal ablation of the tumor.

[0008] Preferably, the optical fiber includes a core and a cladding structure that encloses the core; the core is used to transmit the heating light to the photothermal photosensitive agent; the front end is an integral part formed by the core extending out of the coverage area of ​​the cladding structure along the length of the optical fiber; the spatial structure of the front end is a cylindrical structure, a conical structure, or a combination structure formed by sequentially connecting multiple cylindrical structures.

[0009] Preferably, the optical fiber includes a fiber core, an inner cladding that encloses the fiber core, and an outer cladding that encloses the inner cladding; the front end is a whole formed by the fiber core and the inner cladding extending along the length of the optical fiber beyond the coverage area of ​​the outer cladding; the spatial structure of the front end is a cylindrical structure, a conical structure, or a combination structure formed by sequentially connecting multiple cylindrical structures.

[0010] Preferably, it also includes a fiber optic temperature sensor for monitoring the real-time temperature during the thermal ablation of tumors; the fiber optic temperature sensor is integrated inside the front end; the fiber optic temperature sensor is a fiber optic grating or a mode interferometer sensing structure.

[0011] Preferably, the tumor biomarker sensor is a tumor microenvironment-responsive fluorescent probe or a tumor biomarker fluorescent probe.

[0012] Preferably, the tumor microenvironment-responsive fluorescent probe is a hypoxia fluorescent probe or a pH fluorescent probe; the tumor marker fluorescent probe is an enzyme fluorescent probe, an immunofluorescence probe, or a nucleic acid aptamer fluorescent probe.

[0013] Preferably, it further includes: precious metals or two-dimensional materials;

[0014] The noble metal or the two-dimensional material is disposed on the surface of the optical fiber, and the noble metal or the two-dimensional material is used to enhance the detection fluorescence when the tumor marker fluorescent probe is detected.

[0015] Preferably, it further includes:

[0016] A first optical interface is connected to the optical fiber and is used to transmit signals to the optical fiber;

[0017] The fiber Bragg grating addressing module is used to transmit fiber Bragg grating addressing light to the fiber optic temperature sensor through the first optical interface and detect the fiber Bragg grating reflection signal returned by the fiber optic temperature sensor, so as to realize real-time temperature monitoring and feedback.

[0018] A heating light source module is used to transmit heating light to the front end through the first optical interface to excite the photothermal photosensitizer to generate heat;

[0019] The first optical wave combiner and splitter module has a first port connected to the first optical interface, a second port connected to the fiber Bragg grating addressing module, and a third interface connected to the heating light source module. The first optical wave combiner and splitter module is used to combine or split the heating light and the fiber Bragg grating addressing light.

[0020] Preferably, it further includes:

[0021] The second optical interface is connected to the optical fiber and is used to transmit signals to the optical fiber;

[0022] A fluorescence excitation module is used to emit excitation light to the tumor marker sensor through the second optical interface to excite the tumor marker sensor to generate tumor marker sensor signal light;

[0023] A fluorescence detection module is used to receive and demodulate the signal light from the tumor feature marker sensor to achieve in situ detection of tumors.

[0024] The second light-combining and wave-splitting module has a first port connected to the second optical interface, a second port connected to the fluorescence excitation module, and a third interface connected to the fluorescence detection module. The second light-combining and wave-splitting module is used to combine or decompose the excitation light and the signal light from the tumor feature marker sensor.

[0025] According to specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0026] This invention provides an integrated fiber optic device for in-situ tumor detection and photothermal therapy, comprising: an optical fiber, a tumor biomarker sensor, and a photothermal photosensitizer; the optical fiber includes a front end; the photothermal photosensitizer is disposed internally within the front end; the photothermal photosensitizer receives heating light and generates heat according to the heating light, thereby raising the temperature of the front end; the tumor biomarker sensor is disposed on the surface of the front end; the front end is used to contact a solid tumor to realize the tumor biomarker's identification of the tumor and the photothermal photosensitizer's thermal ablation of the tumor. This invention places the front end of the integrated fiber optic device for in-situ tumor detection and photothermal therapy close to the tumor location, thereby achieving tumor ablation and temperature monitoring throughout the entire diagnosis and treatment process through the photothermal photosensitizer, the tumor biomarker sensor, and, in a specific embodiment, the fiber optic temperature sensor, ensuring real-time information feedback and security. In a specific embodiment, a thermal excitation and detection module is used to control the fiber optic device to complete the above functions. This invention can introduce light energy into the body through a minimally invasive endoscopic intervention and directly reach the tumor lesion to achieve effective killing of deep tumors, thereby overcoming the problem of insufficient penetration of conventional phototherapy into deep tissues. It also has a wide effective treatment range, electrical insulation, minimal trauma, easy operation, rapid response, and short treatment cycle. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0028] Figure 1 This is a schematic diagram of the device structure provided in an embodiment of the present invention;

[0029] Figure 2 This is a schematic diagram of a single-layer cylindrical structure provided in an embodiment of the present invention;

[0030] Figure 3 This is a schematic diagram of a single-layered cone structure provided in an embodiment of the present invention;

[0031] Figure 4 A schematic diagram of a single-layer conical cylinder structure provided in an embodiment of the present invention;

[0032] Figure 5 A schematic diagram of the combined structure of a single-layered conical cylinder and a cylinder provided in an embodiment of the present invention.

[0033] Figure 6 A schematic diagram of the combined structure of a single-layered conical cylinder and a conical cylinder provided in an embodiment of the present invention;

[0034] Figure 7 This is a schematic diagram of a double-clad cylindrical structure provided in an embodiment of the present invention;

[0035] Figure 8 This is a schematic diagram of a double-clad cone structure provided in an embodiment of the present invention;

[0036] Figure 9 A schematic diagram of a double-clad conical cylinder structure provided in an embodiment of the present invention;

[0037] Figure 10 A schematic diagram of the combined structure of a double-clad conical cylinder and a cylinder provided in an embodiment of the present invention.

[0038] Figure 11 A schematic diagram of the combined structure of a double-clad conical cylinder and a conical cylinder provided in an embodiment of the present invention;

[0039] Figure 12 This is a schematic diagram of the structure of the tumor treatment module and the tumor detection module provided in the embodiments of the present invention.

[0040] Symbol explanation:

[0041] 1-Fiber optic cable, 2-Fiber core, 3-Inner cladding, 4-Outer cladding, 5-Photothermal photosensitizer, 6-Fiber optic temperature sensor, 7-Tumor biomarker sensor, 8-Excitation light for tumor biomarker sensor, 9-Signal light for tumor biomarker sensor, 10-Heating light, 11-Temperature sensing and monitoring signal, 12-Cylindrical structure at the front end of a single-clad fiber, 13-Conical structure at the front end of a single-clad fiber, 14-Conical cylindrical structure at the front end of a single-clad fiber, 15-Combined structure of conical cylinder and cylindrical structure at the front end of a single-clad fiber, 16-Conical cylinder and conical cylindrical structure at the front end of a single-clad fiber. The column combination structure includes: 17-Cylindrical structure at the front end of the double-clad optical fiber; 18-Conical structure at the front end of the double-clad optical fiber; 19-Conical cylindrical structure at the front end of the double-clad optical fiber; 20-Combined structure of conical and cylindrical structures at the front end of the double-clad optical fiber; 21-Combined structure of conical and cylindrical structures at the front end of the double-clad optical fiber; 22-First optical interface; 23-Heating light source module; 24-Fiber grating addressing module; 25-First optical wave combining and splitting module; 26-Second optical interface; 27-Fluorescence excitation module; 28-Fluorescence detection module; 29-Second optical wave combining and splitting module. Detailed Implementation

[0042] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0043] The purpose of this invention is to provide an integrated fiber optic device for in situ tumor detection and photothermal therapy, which can introduce light energy into the body through minimally invasive endoscopic intervention and directly reach the tumor lesion to achieve effective killing of deep tumors. This overcomes the problem of insufficient penetration of conventional phototherapy into deep tissues, and has a wide effective treatment range, electrical insulation, minimal trauma, easy operation, rapid response, and short treatment cycle.

[0044] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0045] Figure 1 This is a schematic diagram of the device structure provided in an embodiment of the present invention, such as... Figure 1 As shown, an integrated fiber optic device for in situ tumor detection and photothermal therapy in this embodiment includes: an optical fiber, a tumor biomarker sensor 7, a photothermal photosensitizer 5, and an optical fiber temperature sensor 6.

[0046] The optical fiber includes a front end; the front end is equipped with an optical fiber temperature sensor 6; the front end is internally equipped with a photothermal photosensitizer 5; the photothermal photosensitizer 5 is used to receive heating light 10 and generate heat according to the heating light 10 to raise the temperature of the front end; the surface of the front end is equipped with a tumor feature marker sensor 7; the front end is used to contact a solid tumor to enable the tumor feature marker sensor 7 to identify the tumor and the photothermal photosensitizer 5 to thermally disinfect the tumor; the optical fiber temperature sensor 6 is used to monitor the temperature at which the tumor is disinfected.

[0047] Specifically, the front end is in contact with the outside world, and its surface has fluorescent probes that specifically respond to the tumor microenvironment or tumor markers. The front end contains a photothermal agent (photothermal photosensitizer 5). The front end can contact a solid tumor or be inserted into a solid tumor through puncture or in vivo guidance. The fluorescent probe identifies the tumor. The photothermal agent generates heat under the excitation of light introduced into the optical fiber front end, which heats up the front end and thermally kills the tumor.

[0048] Furthermore, in this embodiment, the front end can be punctured or guided into the body to contact or insert into a solid tumor. The fluorescent probe identifies the tumor, and the photothermal agent generates heat under the excitation of light introduced into the optical fiber front end, thereby heating the front end and thermally ablating the tumor.

[0049] Preferably, the tumor biomarker sensor 7 is a tumor microenvironment-responsive fluorescent probe or a tumor biomarker fluorescent probe. The tumor microenvironment-responsive fluorescent probe is a hypoxia fluorescent probe or a pH fluorescent probe; the tumor biomarker fluorescent probe is an enzyme fluorescent probe, an immunofluorescence probe, or a nucleic acid aptamer fluorescent probe.

[0050] Furthermore, it also includes: precious metals or two-dimensional materials;

[0051] The noble metal or the two-dimensional material is disposed on the surface of the optical fiber, and the noble metal and the two-dimensional material are used to enhance the detection fluorescence when the tumor marker fluorescent probe is detected.

[0052] Specifically, fluorescence enhancement of tumor marker fluorescent probes can be achieved by modifying the surface of optical fibers with noble metals or two-dimensional materials.

[0053] In this embodiment, the front end contains a photothermal agent, which is a rare earth ion, bismuth ion, or cobalt ion.

[0054] In this embodiment, the rare earth ions in the photothermal agent are erbium ions and ytterbium ions.

[0055] Preferably, the optical fiber includes a fiber core 2 and a cladding structure that encloses the fiber core 2; the fiber core is used to transmit the heating light 10 to the photothermal photosensitive agent 5; the front end is an integral part formed by the fiber core 2 extending out of the coverage area of ​​the cladding structure in the optical fiber length direction; the spatial structure of the front end is a cylindrical structure, a conical structure, or a combination structure formed by connecting multiple cylindrical structures in sequence.

[0056] Please see Figures 2 to 6 The front end of the fiber is formed by the fiber core 2 extending out of the cladding structure along the fiber length direction, forming a cylindrical front end structure 12, a conical front end structure 13, a conical cylindrical front end structure 14, a combined structure of conical and cylindrical front ends 15, and a combined structure of conical and cylindrical front ends 16.

[0057] Specifically, in a single-clad fiber structure, the core diameter of the fiber is 30-1000 micrometers, and the radial thickness of the cladding is 5-200 micrometers.

[0058] Furthermore, the length of the front end is 3-100 mm.

[0059] Preferably, the optical fiber includes a fiber core 2, an inner cladding 3 enclosing the fiber core 2, and an outer cladding 4 enclosing the inner cladding 3; the front end is a whole formed by the fiber core 2 and the inner cladding 3 extending outwards from the coverage area of ​​the outer cladding 4 in the length direction of the optical fiber; the spatial structure of the front end is a cylindrical structure, a conical structure, or a combination structure formed by connecting multiple cylindrical structures in sequence.

[0060] Please see Figures 7 to 11 The front end of the double-clad optical fiber is formed by the fiber core 2 and the inner cladding 3 extending outwards to cover the area covered by the outer cladding 4. The front end of the double-clad optical fiber is a cylindrical structure 17, a conical structure 18, a conical cylindrical structure 19, a combined structure 20 of conical and cylindrical structures, and a combined structure 21 of conical and cylindrical structures.

[0061] Specifically, in a double-clad fiber structure, the fiber core 2 has a diameter of 3-60 micrometers, the inner cladding 3 has a radial thickness of 25-500 micrometers, and the outer cladding 4 has a radial thickness of 5-200 micrometers.

[0062] Furthermore, the tumor marker sensor 7 is excited by the tumor marker sensor excitation light 8 transmitted downlink in the inner capsule 3. The tumor marker sensor signal light 9 of the tumor marker sensor 7 is transmitted uplink in the inner capsule 3.

[0063] Specifically, the excitation light for the tumor biomarker sensor is 450 nm blue-violet light.

[0064] Preferably, the fiber optic temperature sensor 6 is disposed inside the front end; the fiber optic temperature sensor 6 is a fiber optic grating or mode interferometer sensing structure.

[0065] Specifically, the fiber optic temperature sensor 6 is a fiber Bragg grating. The fiber optic temperature sensor 6 emits a temperature sensing and monitoring signal 11, which is transmitted upstream in the fiber core 2.

[0066] Furthermore, the operating band of the temperature sensing monitoring signal 11 is the C-band.

[0067] In practical applications, the following devices are also required for implementation, such as... Figure 12 As shown:

[0068] The first optical interface 22 is connected to the optical fiber and is used to transmit signals to the optical fiber;

[0069] The fiber Bragg grating addressing module 24 is used to transmit fiber Bragg grating addressing light to the fiber optic temperature sensor 6 through the first optical interface 22, and detect the fiber Bragg grating reflection signal returned by the fiber optic temperature sensor 6, so as to realize real-time temperature monitoring and feedback.

[0070] The heating light source module 23 is used to transmit heating light 10 to the front end through the first optical interface 22 to excite the photothermal photosensitizer 5 to generate heat.

[0071] The first optical wave combiner / demultiplexer module 25 has a first port connected to the first optical interface 22, a second port connected to the fiber Bragg grating addressing module 23, and a third interface connected to the heating light source module 10. The first optical wave combiner / demultiplexer module 25 is used to combine or decompose the heating light 10 and the fiber Bragg grating addressing light.

[0072] Specifically, the first optical interface 22, the fiber optic grating addressing module 24, the heating light source module 23, and the first optical wave combining and splitting module 25 constitute the tumor treatment module, wherein the fiber optic grating addressing module 24 is a fiber optic spectrum analyzer or optical wavelength meter.

[0073] Preferably, it further includes:

[0074] The second optical interface 26 is connected to the optical fiber and transmits signals to the optical fiber;

[0075] The fluorescence excitation module 27 is used to emit the excitation light (tumor feature marker sensor excitation light 8) to the tumor feature marker sensor through the second optical interface 26, so as to excite the tumor feature marker sensor 7 to generate tumor feature marker sensor signal light 9.

[0076] The fluorescence detection module 28 is used to receive the signal light 9 from the tumor feature marker sensor and demodulate it to achieve in situ detection of tumors;

[0077] The second light-combining and wave-splitting module 29 has a first port connected to the second optical interface 26, a second port connected to the fluorescence excitation module 27, and a third interface connected to the fluorescence detection module 28. The second light-combining and wave-splitting module 29 is used to combine or decompose the excitation light and the tumor feature marker sensor signal light 9.

[0078] Specifically, the second optical interface 26, the fluorescence excitation module 27, the fluorescence detection module 28, and the second light combination and wave splitting module 29 constitute the tumor treatment module, wherein the fluorescence detection module 28 is a fiber optic fluorescence spectrometer.

[0079] Those skilled in the art will readily recognize that when a double-clad fiber structure is used, the excitation light 8 and signal light 9 of the tumor biomarker sensor are transmitted in the inner cladding of the fiber, while the heating light and fiber Bragg grating addressing light are transmitted in the fiber core. The first optical interface 22 is coupled to the fiber core of the double-clad fiber, and the second optical interface is coupled to the inner cladding of the double-clad fiber. The first optical interface 22 and the second optical interface 26 can be integrated together.

[0080] The beneficial effects of this invention are as follows:

[0081] 1. The integrated fiber optic device for in situ tumor detection and photothermal therapy proposed in this invention, compared with conventional optical tumor diagnosis and treatment technology, can introduce light energy into the body through minimally invasive endoscopic intervention and directly reach the tumor lesion, thereby achieving effective killing of deep tumors and overcoming the problem of insufficient penetration of conventional phototherapy into deep tissues.

[0082] 2. The fiber optic tumor diagnostic and treatment device proposed in this invention can solve the problems of insufficient control over the effective treatment range and the problem of live operation in current conventional endoscopic tumor ablation technology. It has the advantages of electrical insulation, minimal trauma, easy operation, rapid response, and short treatment cycle.

[0083] 3. Unlike conventional fiber optic phototherapy, the fiber optic tumor diagnostic and treatment device proposed in this invention uses optical fibers that are not only light transmission tools, but also diagnostic tools and treatment instruments. This avoids the problem of multiple operations in medical treatment, effectively reducing risks and improving efficiency.

[0084] 4. Unlike conventional fiber optic phototherapy, the fiber optic tumor diagnostic and therapeutic device proposed in this invention fully utilizes the structural and material properties of optical fibers. By using methods such as surface fixation and internal lattice doping, it can not only firmly fix photosensitive drug materials to the surface of the optical fiber or enclose them inside the optical fiber, reducing the risk of drug retention in the body, but also achieve more complete and efficient light energy conversion, control the overall light irradiation power, and greatly improve the targeting and safety of diagnosis and treatment.

[0085] 5. Unlike conventional fiber optic phototherapy, the fiber optic tumor diagnostic and treatment device proposed in this invention adopts a double-clad fiber design, which can distinguish uplink and downlink signals simultaneously in terms of wavelength and space through an optical transmission device, thereby improving the accuracy of diagnosis and treatment.

[0086] 6. Unlike conventional fiber optic phototherapy, the fiber optic tumor diagnostic and therapeutic device proposed in this invention can achieve real-time temperature monitoring and feedback during the treatment process using a temperature sensor integrated inside the device, while performing photothermal therapy, further improving medical safety.

[0087] 7. The integrated fiber optic device for in situ tumor detection and photothermal therapy proposed in this invention has high scalability in terms of wavelength, spatial and temporal selectivity. It can be combined with a variety of sensing and disease treatment technologies to achieve integrated precision diagnosis and treatment of deep tumors.

[0088] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0089] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of the present invention. Furthermore, those skilled in the art will recognize that, based on the ideas of the present invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. An integrated fiber optic device for in-situ tumor detection and photothermal therapy, characterized in that, include: Fiber optics, tumor biomarker sensors, photothermal photosensitizers; The optical fiber includes a front end; the photothermal photosensitizer is disposed inside the front end. The photothermal photosensitizer is used to receive heating light and generate heat according to the heating light to raise the temperature of the front end; the surface of the front end is provided with the tumor feature marker sensor; the tumor feature marker sensor is a tumor microenvironment responsive fluorescent probe or a tumor marker fluorescent probe; the front end is used to contact a solid tumor to realize the tumor feature marker sensor's identification of the tumor and the photothermal photosensitizer's thermal ablation of the tumor; It also includes a fiber optic temperature sensor for monitoring the real-time temperature during the thermal ablation of tumors; the fiber optic temperature sensor is integrated inside the front end; the fiber optic temperature sensor is a fiber optic grating or mode interferometer sensing structure.

2. The integrated fiber optic device for in-situ tumor detection and photothermal therapy according to claim 1, characterized in that, The optical fiber includes a core and a cladding structure that encloses the core; the core is used to transmit the heating light to the photothermal photosensitive agent; the front end is an integral part formed by the core extending out of the coverage area of ​​the cladding structure along the length of the optical fiber; the spatial structure of the front end is a cylindrical structure, a conical structure, or a combination structure formed by connecting multiple cylindrical structures in sequence.

3. The integrated fiber optic device for in-situ tumor detection and photothermal therapy according to claim 1, characterized in that, The optical fiber includes a core, an inner cladding that encloses the core, and an outer cladding that encloses the inner cladding; the front end is a whole formed by the core and inner cladding extending along the length of the optical fiber beyond the coverage area of ​​the outer cladding; the spatial structure of the front end is a cylindrical structure, a conical structure, or a combination structure formed by sequentially connecting multiple cylindrical structures.

4. The integrated fiber optic device for in-situ tumor detection and photothermal therapy according to claim 1, characterized in that, The tumor microenvironment-responsive fluorescent probe is a hypoxia fluorescent probe or a pH fluorescent probe; the tumor marker fluorescent probe is an enzyme fluorescent probe, an immunofluorescence probe, or a nucleic acid aptamer fluorescent probe.

5. The integrated fiber optic device for in-situ tumor detection and photothermal therapy according to claim 1, characterized in that, Also includes: A first optical interface is connected to the optical fiber and is used to transmit signals to the optical fiber; The fiber Bragg grating addressing module is used to transmit fiber Bragg grating addressing light to the fiber optic temperature sensor through the first optical interface and detect the fiber Bragg grating reflection signal returned by the fiber optic temperature sensor, so as to realize real-time temperature monitoring and feedback. A heating light source module is used to transmit heating light to the front end through the first optical interface to excite the photothermal photosensitizer to generate heat; The first optical wave combiner and splitter module has a first port connected to the first optical interface, a second port connected to the fiber Bragg grating addressing module, and a third interface connected to the heating light source module. The first optical wave combiner and splitter module is used to combine or split the heating light and the fiber Bragg grating addressing light.

6. The integrated fiber optic device for in-situ tumor detection and photothermal therapy according to claim 1, characterized in that, Also includes: The second optical interface is connected to the optical fiber and is used to transmit signals to the optical fiber; A fluorescence excitation module is used to emit excitation light to the tumor marker sensor through the second optical interface to excite the tumor marker sensor to generate tumor marker sensor signal light; A fluorescence detection module is used to receive and demodulate the signal light from the tumor feature marker sensor to achieve in situ detection of tumors. The second light-combining and wave-splitting module has a first port connected to the second optical interface, a second port connected to the fluorescence excitation module, and a third interface connected to the fluorescence detection module. The second light-combining and wave-splitting module is used to combine or decompose the excitation light and the signal light from the tumor feature marker sensor.

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