A fully automatic sampler

Abstract

The present application relates to a fully automatic sample dispenser, belonging to the technical field of medical equipment, comprising a casing and a main frame, wherein the main frame is located inside the casing, and further comprising a centrifugal mechanism, a sample dispenser mechanism, a tip box mechanism, a collection mechanism, and a test tube mechanism arranged on the main frame; the sample dispenser mechanism is slidingly arranged on the main frame, and the centrifugal mechanism, the tip box mechanism, the collection mechanism, and the test tube mechanism are all located within the travel range of the sample dispenser mechanism, a tip is placed in the tip box mechanism, and a sample test tube and a centrifuge tube are placed in the test tube box mechanism; the centrifugal mechanism comprises a sliding assembly, a rotating assembly, and a centrifugal disk, wherein the centrifugal disk is slidingly arranged on the main frame, and a centrifugal chip is connected to the centrifugal disk, the sliding assembly is used to drive the centrifugal disk to slide on the main frame, a clearance port is provided on the casing, and the centrifugal disk slides in a direction away from the casing through the clearance port, and the rotating assembly is used to drive the centrifugal chip to rotate to centrifuge the sample. The present application has the effect of improving the experimental efficiency of the fully automatic sample dispenser.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a fully automatic sample dispenser. Background Art

[0002] Fully automatic sample handling equipment is used for fully automated sample and reagent dilution, distribution, mixing, and document management of related data. These devices are commonly used in medical equipment technology, particularly in blood testing equipment. Patient blood samples are typically collected in test tubes and then transferred to reaction cups or test tubes using sample and reagent needles, pipette tips, and other devices.

[0003] In related technologies, fully automatic sample dispensers, under the control of hardware and software systems, automatically dispense samples and reagents, perform centrifugation, and mix them according to their control requirements. During these various operations, including the centrifugation step, the sample dispenser transfers the blood sample to the centrifuge chip of the centrifuge mechanism, which then centrifuges the blood sample. After centrifugation, the sample dispenser adds the centrifuged blood sample to the reaction tube. The operator then opens the centrifuge cover and replaces the centrifuge chip.

[0004] With respect to the above-mentioned related technologies, the inventors believe that before replacing the centrifugal chip, the cover of the centrifugal mechanism needs to be opened manually, which affects the experimental efficiency. Summary of the Invention

[0005] In order to improve the experimental efficiency of a fully automatic sample injector, the present application provides a fully automatic sample injector.

[0006] This application provides a fully automatic sample dispenser, which adopts the following technical solutions:

[0007] A fully automatic sample loading instrument comprises a housing and a main frame, wherein the main frame is located within the housing and further comprises a centrifugal mechanism, a sample loading mechanism, a pipette tip box mechanism, a collection mechanism, and a test tube box mechanism, which are arranged on the main frame; the sample loading mechanism is slidably arranged on the main frame, and the centrifugal mechanism, the pipette tip box mechanism, the collection mechanism, and the test tube box mechanism are all located within the travel range of the sample loading mechanism; the pipette tip box mechanism contains pipette tips, and the test tube box mechanism contains sample tubes and centrifuge tubes;

[0008] The centrifugal mechanism includes a sliding assembly, a rotating assembly and a centrifugal disk. The centrifugal disk is slidingly arranged on the main frame, and a centrifugal chip is detachably connected to the centrifugal disk. The sliding assembly includes a clamping portion and a sliding portion. The clamping portion is used to drive the centrifugal chip to approach or move away from the rotating assembly, so that the rotating assembly drives the centrifugal chip to rotate, thereby centrifuging the sample; the sliding portion is used to drive the centrifugal disk to slide on the main frame, and a clearance port is provided on the casing. The centrifugal disk slides in a direction away from the casing through the clearance port to facilitate the replacement of the centrifugal chip.

[0009] By adopting the above technical solution, when using a fully automatic sampler to add samples, the sample adding mechanism will first slide on the main frame to install the pipette tip in the pipette tip box mechanism into the sample adding mechanism, and then the sample adding mechanism will continue to slide on the main frame to a position close to the test tube box mechanism to add the sample in the sample tube into the pipette tip, and then the sample adding mechanism will slide to the top of the centrifugal mechanism to add the sample in the pipette tip into the centrifugal chip on the centrifugal disk, and then the clamping part will drive the centrifugal disk to drive the centrifugal chip to approach the rotating component, so that the rotating component can drive the centrifugal chip to rotate and centrifuge the sample. After centrifugation is completed, the centrifugal chip stops rotating, and the sample adding mechanism will add the sample in the centrifugal chip into the pipette tip, and then slide on the main frame to remove the pipette tip. The sample in the centrifuge tube is added to the centrifuge tube, and finally the sample adding mechanism slides on the main frame to a position close to the collecting mechanism, and the suction head is placed in the collecting mechanism; in the present technical solution, when the centrifugal chip needs to be replaced, the clamping part is started, and the clamping part drives the centrifugal disk to drive the centrifugal chip to move in the direction away from the rotating component, and then the sliding part is started, and the sliding part drives the centrifugal disk to drive the centrifugal chip to slide out of the clearance port of the casing, so that the staff can replace the centrifugal chip. After the replacement is completed, the sliding part drives the centrifugal disk to drive the replaced centrifugal chip back to its position. The present application cooperates with the clamping part and the sliding part to automatically drive the centrifugal disk to the outside of the casing, so that the staff can replace the centrifugal chip, thereby improving the experimental efficiency of the fully automatic sample adder.

[0010] Optionally, the main frame includes an upper base plate and a lower base plate arranged in parallel, and the upper base plate and the lower base plate are connected by a connecting column. The centrifugal mechanism also includes a centrifugal frame, and the centrifugal frame is slidably arranged on the lower base plate; the sliding part and the clamping part are both arranged on the lower base plate, and the rotating assembly includes a rotating motor arranged on the lower base plate, and the rotating motor is transmission-connected with a clamping block. A clamping groove is provided in the middle of the centrifugal chip, and the clamping part is used to drive the centrifugal frame to slide in a direction close to or away from the upper base plate, so that the clamping block is located in the clamping groove and is clamped and connected to the centrifugal disk.

[0011] By adopting the above technical solution, the upper base plate and the lower base plate are connected by a connecting column, which improves the space utilization rate of the entire automatic sample injector, and is divided into an upper and lower layer, so that the cooperation between the various mechanisms is more convenient and accurate; the centrifugal disk is arranged on the centrifugal frame, and the centrifugal frame drives the centrifugal disk to slide on the lower base plate, thereby improving the sliding stability of the centrifugal disk; when the centrifugal chip on the centrifugal disk needs to perform a centrifugal step on the sample, when the sample is added to the centrifugal chip, the clamping part drives the centrifugal frame to slide in the direction away from the upper base plate until the clamping groove in the middle of the centrifugal chip is clamped with the clamping block, so that the rotating motor drives the centrifugal chip to rotate, and the sample in the centrifugal chip is centrifuged.

[0012] Optionally, the clamping part includes a clamping plate, a clamping motor and a clamping block slidingly arranged on the clamping plate, the clamping plate is arranged on the lower base plate, the clamping motor is arranged on the clamping plate, and is used to drive the clamping block to slide on the clamping plate, the clamping block is connected to the centrifugal frame, and the clamping block drives the centrifugal frame to slide toward or away from the upper base plate, thereby realizing the clamping or disengagement of the centrifugal chip and the clamping block.

[0013] By adopting the above technical solution, the clamping plate serves as the mounting base of the clamping motor, so that the clamping motor can be installed on the lower base plate. Since the clamping block is connected to the centrifugal frame, the clamping motor can slide on the lower base plate by driving the clamping block, so that the clamping block drives the centrifugal frame to slide toward or away from the upper base plate, thereby realizing the clamping or disengagement of the centrifugal chip and the clamping block.

[0014] - tached to said driving mechanism, a floating feeder mounted on 'said mechanism, means for raising and lowering the casing vertically relative to the engine, means for swinging endsat the rear of the sides of said frame, and a 4 grounded mounting plate, said sliding seat being provided with a at least one movable frame, said sliding seat being provided with a at least one movable frame

[0015] By adopting the above technical solution, when the centrifugal chip needs to be replaced, the sliding motor is started, and the sliding motor drives the driving rod to rotate, so that the sliding block at one end of the driving rod can slide in the sliding groove of the driving plate. At the same time, due to the limiting effect of the sliding groove, the driving rod can drive the driving plate to drive the sliding frame to slide on the centrifugal frame, so that the centrifugal frame drives the centrifugal disk to move toward or away from the yield opening; in the process of the sliding motor driving the driving rod to rotate, the driving rod will abut against the inclined surface of the limiting block of the limiting assembly, thereby reducing the situation where the sliding frame slips out of the centrifugal frame.

[0016] Optionally, the rotating assembly also includes a rotating frame, which is arranged on the lower base plate and located in the centrifugal frame, the rotating motor is arranged on the rotating frame, the output shaft of the rotating motor passes through the rotating frame and is transmitted and connected to a rotating column, the rotating column is connected to the clamping block at one end away from the rotating motor, and a limit plate and a baffle are also sleeved on the rotating column, the baffle is arranged in the direction close to the rotating frame, the limit plate is arranged between the baffle and the clamping block, and the cross-section of the limit plate is larger than the cross-section of the clamping block, and the side of the limit plate away from the baffle abuts against the centrifugal chip; a number of limit members are provided on the rotating frame, and a number of the limit members are provided with limit slots, and the edge of the baffle is located in the limit slot of each of the limit members.

[0017] By adopting the above technical solution, when the snap-in groove of the centrifugal chip is snapped with the snap-in block, the limit plate is located below the snap-in block and abuts against the centrifugal chip. Since the cross-section of the limit plate is larger than the cross-section of the snap-in block, the limit plate plays a limiting role on the centrifugal chip, reducing the situation where the centrifugal chip falls off from the snap-in block; when the rotating motor drives the centrifugal chip to rotate, the rotating column on the output shaft of the rotating motor will rotate, and the rotating column also drives the baffle to rotate. The baffle is located in the limiting groove of the limiting member and rotates, reducing the tilt of the baffle during the rotation process, so that the rotating motor can more stably drive the centrifugal chip to rotate.

[0018] Optionally, a number of sliding rods are connected to one side of the centrifugal frame close to the lower bottom plate, and the sliding rods are parallel to each other, one end of the sliding rod is connected to the centrifugal frame, and the other end is slidably connected to the lower bottom plate, and each sliding rod is provided with a buffer spring, one side of the buffer spring is connected to the centrifugal frame, and the other side is connected to the lower bottom plate.

[0019] By adopting the above technical solution, when the clamping motor drives the centrifugal frame to slide away from the upper bottom plate, the end of the sliding rod away from the centrifugal frame will slide with the lower bottom plate. At the same time, the buffer spring is compressed and deformed, giving the centrifugal frame an elastic force away from the lower bottom plate, thereby reducing the collision between the centrifugal frame and the lower bottom plate, which causes the sample on the centrifugal chip to be shaken and splashed. In addition, due to the buffering effect of the buffer spring, the service life of the centrifugal frame is also improved.

[0020] Optionally, the suction head box mechanism includes a guide plate, a mounting bracket, a box body and a ball buckle assembly, the guide plate is slidably set on the main frame, the mounting bracket is set on the guide plate, the box body is detachably set on the mounting bracket, the number of suction heads is several, and they are placed in the box body; the ball buckle assembly is used to detachably connect the guide plate to the main frame.

[0021] By adopting the above technical solution, a number of pipette tips are placed in the box body of the pipette tip box mechanism for easy use by the sample loading mechanism; when the pipette tips in the box body are used up, the staff pulls the guide plate, slides on the main frame through the guide plate, pulls the box body out of the casing, and then places the pipette tips in the box body. Then, the staff pushes the guide plate to push the box body into the casing. At the same time, the guide plate is detachably connected to the main frame through the ball buckle assembly.

[0022] Optionally, the test tube box mechanism includes a screw motor assembly and a test tube rack arranged on the main frame, the test tube rack is slidably arranged on the main frame, the test tube rack is detachably connected to the sample tube and the centrifuge tube, and the screw motor assembly is used to drive the test tube rack to slide on the main frame.

[0023] By adopting the above technical solution, the screw motor assembly drives the test tube holder to slide out from the main frame, and then the staff places the sample tube containing the sample on the test tube holder, and also places the centrifuge tube on the test tube holder. Finally, the screw motor assembly drives the test tube holder back to its position.

[0024] Optionally, the collection mechanism includes a connecting frame, a collection box and a push-button switch assembly. The collection box is slidably set on the connecting frame for collecting suction heads. The push-button switch assembly is set on the connecting frame for removing the collection box card and setting it on the main frame.

[0025] By adopting the above technical solution, the collection box is set on the main frame through the connecting frame. When the waste tips in the collection box need to be cleaned, the staff holds the collection box and then removes the collection box from the main frame through the push-button switch assembly to facilitate cleaning of the waste tips in the collection box.

[0026] Optionally, the loading mechanism includes a moving component, a driving component, a gun head assembly, a disassembly component and a mounting frame slidably arranged on the main frame, the moving component is arranged on the main frame, and is used to drive the mounting frame to slide on the main frame, the driving component, the gun head assembly and the disassembly component are all arranged on the mounting frame, the driving component includes a mounting plate and a driving motor arranged on the mounting frame, the driving motor is used to drive the mounting plate to slide on the machine body, the gun head assembly includes a tip connecting rod and an air pump, the tip connecting rod is arranged on the mounting plate, and the tip connecting rod is detachably connected to the tip at one end away from the mounting plate, the air pump is arranged on the mounting frame, and is used to drive the tip to suck or discharge samples, and the disassembly mechanism is arranged on the mounting frame, and is used to automatically disassemble the tip.

[0027] By adopting the above technical solution, when it is necessary to add samples, the moving component drives the mounting frame to slide on the main frame, and then the driving motor drives the mounting plate to slide on the mounting frame. The mounting plate drives the tip connecting rod and the air pump to approach the tip in the tip box mechanism until the tip connecting rod is away from the end of the mounting plate and is plugged into the tip. Then the driving motor drives the mounting plate to reset. Then the moving component can drive the mounting frame to the top of the test tube box mechanism, the air pump starts, drives the tip to aspirate the sample, and adds the sample to the centrifuge chip. After the sample is centrifuged, the sample is added to the centrifuge tube. Finally, the moving component drives the mounting frame to the collection mechanism, and the disassembly mechanism on the mounting frame will start to automatically disassemble the tip.

[0028] In summary, this application includes at least one of the following beneficial technical effects:

[0029] 1. In the present technical solution, when the centrifugal chip needs to be replaced, the clamping part is activated, the clamping part drives the centrifugal disc to move the centrifugal chip in the direction away from the rotating assembly, and then the sliding part is activated, the sliding part drives the centrifugal disc to slide the centrifugal chip out of the yield opening of the casing, so that the staff can replace the centrifugal chip. After the replacement is completed, the sliding part drives the centrifugal disc to drive the replaced centrifugal chip back to its original position. The present application can automatically drive the centrifugal disc to the outside of the casing through the cooperation between the clamping part and the sliding part, so that the staff can replace the centrifugal chip, thereby improving the experimental efficiency of the fully automatic sampler;

[0030] 2. When the centrifugal chip needs to be replaced, the sliding motor is started, which drives the driving rod to rotate, so that the sliding block at one end of the driving rod can slide in the sliding groove of the driving plate. At the same time, due to the limiting effect of the sliding groove, the driving rod can drive the driving plate to drive the sliding frame to slide on the centrifugal frame, so that the centrifugal frame drives the centrifugal disc to move towards or away from the yield port;

[0031] 3. The drive motor drives the mounting plate to slide on the mounting frame until the end of the pipette tip connecting rod away from the mounting plate is plugged into the pipette tip. Then the moving assembly can drive the mounting frame to the top of the test tube box mechanism. The air pump starts to drive the pipette tip to aspirate the sample and add the sample to the centrifuge chip. After the sample is centrifuged, it is added to the centrifuge tube. Finally, the moving assembly drives the mounting frame to the collection mechanism. The disassembly mechanism on the mounting frame will start to automatically disassemble the pipette tip. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a schematic diagram of the overall structure of the fully automatic sample injector of the embodiment of the present application.

[0033] Figure 2 This is a partial structural diagram of the fully automatic sample injector according to an embodiment of the present application, to illustrate the connection relationship between various mechanisms and the main frame.

[0034] Figure 3 This is a partial structural diagram of the fully automatic sample loading instrument according to an embodiment of the present application, illustrating the connection relationship between the sample loading mechanism and the upper base plate.

[0035] Figure 4 It is a schematic diagram of the overall structure of the sample loading mechanism of the fully automatic sample loading instrument according to the embodiment of the present application.

[0036] Figure 5 This is an exploded view of the fully automatic sample injector according to an embodiment of the present application, to illustrate the connection between the tip box mechanism and the lower base plate.

[0037] Figure 6 This is an exploded view of the fully automatic sample injector according to an embodiment of the present application, to illustrate the connection between the test tube box mechanism and the lower base plate.

[0038] Figure 7 yes Figure 6 Enlarged view of part A.

[0039] Figure 8 It is a partial structural diagram of the fully automatic sample injector of an embodiment of the present application, which shows the connection relationship between the collection mechanism and the upper base plate.

[0040] Figure 9 It is a partial structural diagram of the fully automatic sample injector of an embodiment of the present application, which shows the connection relationship between the centrifugal mechanism and the lower base plate.

[0041] Figure 10 It is an exploded view of the centrifugal mechanism of the fully automatic sample injector according to an embodiment of the present application.

[0042] Figure 11 It is a partial structural schematic diagram of the centrifugal mechanism of the fully automatic sample injector according to an embodiment of the present application, to illustrate the connection relationship between the sliding part and the sliding frame.

[0043] Figure 12 It is a partial structural diagram of the centrifugal mechanism of the fully automatic sample injector according to an embodiment of the present application, to illustrate the connection relationship between the sliding frame and the centrifugal disk.

[0044] Figure 13 yes Figure 9 Magnified view of part B.

[0045] Figure 14 It is a schematic diagram of the overall structure of the rotating assembly of the centrifugal mechanism of the fully automatic sample injector according to the embodiment of the present application.

[0046] Explanation of Reference Numerals: 1. Casing; 11. Giving way; 2. Main frame; 21. Upper base plate; 22. Lower base plate; 221. Limiting assembly; 2211. Fixing plate; 2212. Limiting block; 2213. Buffer plate; 222. Motor bracket; 23. Connecting column; 24. Guide rail assembly; 241. Guide rail; 2411. Limiting screw; 242. Guide block; 3. Loading mechanism; 31. Moving assembly; 311. X-drive unit; 3111. X-drive block; 312. Y-drive unit; 3121. Y-drive block; 313. Drive plate; 314. Drive plate; 32. Drive assembly; 321. Mounting plate; 322, drive motor; 323, drive block; 33, gun head assembly; 331, suction head connecting rod; 332, air pump; 34, disassembly assembly; 341, support part; 3411, first support plate; 3412, second support plate; 3413, support rod; 34131, support spring; 342, limit part; 3421, connecting plate; 34211, limit column; 3422, connecting frame; 35, mounting frame; 4, centrifugal mechanism; 41, sliding assembly; 411, sliding part; 4111, sliding motor; 4112, drive rod; 41121, sliding block; 4113, drive plate; 41131, Sliding groove; 4114, reinforcing strip; 412, clamping part; 4121, clamping plate; 4122, clamping motor; 4123, clamping block; 42, rotating assembly; 421, rotating motor; 422, rotating column; 4221, clamping block; 4222, limiting plate; 4223, baffle; 423, rotating frame; 4231, limiting member; 42311, limiting groove; 43, centrifugal frame; 431, centrifugal disc; 4311, plug-in column; 432, centrifugal chip; 4321, clamping groove; 433, sliding frame; 434, fixing tube; 435, sliding rod; 4351, buffer spring; 4352, limiting screw Mother; 5. Tip box mechanism; 51. Guide plate; 52. Mounting bracket; 521. Placement plate; 5211. Placement slot; 522. Mounting rod; 53. Box body; 531. Tip; 54. Ball buckle assembly; 55. Housing; 551. Handheld slot; 6. Test tube box mechanism; 61. Test tube bracket; 611. Sample test tube; 612. Centrifuge tube; 613. Fixed sleeve; 614. Support member; 6141. Support plate; 6142. Support block; 6413. Elastic sheet; 615. Fixed rod; 62. Outer cover; 7. Collection mechanism; 71. Fixing rack; 72. Collection box; 73. Push-button switch assembly. DETAILED DESCRIPTION

[0047] The present application is further described in detail below with reference to the accompanying drawings.

[0048] The embodiment of the present application discloses a fully automatic sample dispenser. Figure 1 and Figure 2The fully automatic sample loading instrument includes a housing 1 and a main frame 2, and the main frame 2 is arranged in the housing 1. The main frame 2 includes an upper base plate 21 and a lower base plate 22, the upper base plate 21 and the lower base plate 22 are arranged parallel to each other, and the four corners of the upper base plate 21 and the lower base plate 22 facing each other are connected by connecting columns 23, and screws are used for connection in this embodiment. The fully automatic sample loading instrument also includes a centrifugal mechanism 4, a sample loading mechanism 3, a pipette box mechanism 5, a collection mechanism 7 and a test tube box mechanism 6. The sample loading mechanism 3 is slidably arranged on the upper base plate 21, and the centrifugal mechanism 4, the pipette box mechanism 5, the collection mechanism 7 and the test tube box mechanism 6 are all slidably arranged on the lower base plate 22, and the centrifugal mechanism 4, the pipette box mechanism 5, the collection mechanism 7 and the test tube box mechanism 6 are all located within the travel range of the sample loading mechanism 3. In this embodiment, a clearance slot is defined in the middle of the upper base plate 21 and extends through both sides of the upper base plate 21. This clearance slot facilitates the sample loading mechanism 3 to perform experimental operations on other mechanisms. The housing 1 is provided with a number of clearance openings 11 corresponding to each mechanism. Each mechanism can slide out of the housing 1 through the clearance openings 11, facilitating experimental operations by personnel.

[0049] Reference Figure 3 The loading mechanism 3 includes a moving assembly 31 and a mounting frame 35. The moving assembly 31 includes an X-drive unit 311 and a Y-drive unit 312. The Y-drive unit 312 includes a mounting base and a screw motor assembly. The mounting base is screwed to the upper base plate 21. The screw motor assembly includes a motor, a screw, and a Y transmission block 3121. The motor is screwed to the mounting base and is in transmission connection with the screw. The end of the screw away from the motor is rotatably connected to the mounting base. The Y transmission block 3121 is threadedly connected to the screw. Two guide rail assemblies 24 are also provided on the upper base plate 21. The guide rail assembly 24 includes a guide rail 241 and a guide block 242. The two guide rails 241 are respectively provided on either side of the clearance slot and are connected by screws in this embodiment. The two guide rails 241 are parallel to each other, and a guide block 242 is slidably mounted on each guide rail 241. A limit screw 2411 is threadedly connected to one end of each guide rail 241. The limit screw 2411 abuts against the guide block 242, thereby preventing the guide block 242 from falling off the guide rail 241. The Y transmission block 3121 is connected to the guide block 242 via a drive plate 313. The two guide blocks 242 are connected via a transmission plate 314, which in this embodiment is connected using screws.

[0050] The X-drive unit 311 includes a mounting base and a lead screw motor assembly. The mounting base is screwed to the transmission plate 314. The lead screw motor assembly includes a motor, a lead screw, and an X-drive block 3111. The motor is screwed to the mounting base and is in driving connection with the lead screw. The end of the lead screw, which is remote from the motor, is rotatably connected to the mounting base. The X-drive block 3111 is threadedly connected to the lead screw. The mounting frame 35 is screwed to the X-drive block 3111. The motor drives the Y-drive block 3121, which causes the mounting frame 35 to reciprocate on the guide rail 241.

[0051] Reference Figure 3 and Figure 4 The loading mechanism 3 further includes a driving assembly 32 and a gun head assembly 33, both of which are mounted on a mounting frame 35. The driving assembly 32 includes a driving motor 322 and a mounting plate 321. The driving motor 322 is mounted on the mounting frame 35 via screws. The driving motor 322 is connected to a screw rod, and one end of the screw rod away from the driving motor 322 is rotatably connected to the mounting frame 35. The screw rod is further threadedly connected to a driving block 323, wherein the mounting plate 321 is connected to the driving block 323 via screws. The driving motor 322 can drive the driving block 323 to drive the mounting plate 321 to reciprocate on the driving screw rod.

[0052] The gun tip assembly 33 includes a tip connecting rod 331 and an air pump 332. The tip connecting rod 331 used in this embodiment is a quasi-cylindrical structure, wherein one end of the tip connecting rod 331 is connected to the mounting plate 321 via screws, and the end of the tip connecting rod 331 away from the mounting plate 321 can be plugged into the tip 531. An air guide hole is also defined within the tip connecting rod 331, and one end of the air guide hole extends through the end of the tip connecting rod 331 away from the mounting plate 321 and communicates with the tip 531. The air pump 332 is connected to the air guide hole in the tip connecting rod 331 via an air pipe, and can drive the tip 531 through the air pipe to aspirate or discharge the sample.

[0053] The loading mechanism 3 also includes a disassembly assembly 34, which is disposed on the mounting bracket 35 and is used to automatically disassemble the suction head 531. The disassembly mechanism includes a support portion 341 and a stop portion 342. The support portion 341 includes a first support plate 3411, a second support plate 3412, and a support rod 3413. The first support plate 3411 and the second support plate 3412 are located on either side of the mounting plate 321 and are connected by the support rod 3413. One end of the support rod 3413 is screwed to the first support plate 3411, and the other end passes through the mounting plate 321 and is screwed to the second support plate 3412. The support rod 3413 is slidably connected to the mounting plate 321. There are at least two support rods 3413, which are parallel to each other. In this embodiment, there are two support rods 3413. Each support rod 3413 is also sleeved with a support spring 34131. One side of the support spring 34131 is bonded to the side of the first support plate 3411 facing the mounting plate 321, and the other side is bonded to the side of the mounting plate 321 facing the first support plate 3411. The second support plate 3412 is sleeved on the nozzle connecting rod 331 and is slidably connected to the nozzle connecting rod 331. The side of the second support plate 3412 facing away from the mounting plate 321 abuts against the nozzle 531.

[0054] The limiting portion 342 includes a connecting plate 3421 and a connecting frame 3422. In this embodiment, the connecting frame 3422 is a pair of parallel plate-like structures. One end of the connecting frame 3422 is screwed to the mounting frame 35, and the other end is screwed to the connecting plate 3421. The connecting plate 3421 used in this embodiment is a rectangular plate-like structure. A limiting post 34211 is provided in the middle of the connecting plate 3421 and extends through the connecting plate 3421. In this embodiment, the limiting post 34211 is screwed. The end of the limiting post 34211 away from the connecting plate 3421 abuts the first support plate 3411.

[0055] Reference Figure 2 and Figure 5 The tip rack mechanism 5 includes a guide plate 51, a mounting bracket 52, a rack body 53, and a housing 55. The lower base plate 22 is also provided with a guide rail assembly 24. The guide plate 51 is connected to the guide block 242 via screws, and the mounting bracket 52 is screwed onto the guide plate 51. The mounting bracket 52 includes a placement plate 521 and a mounting rod 522. The placement plate 521 is connected to the guide plate 51 via the mounting rod 522. A placement slot 5211 is defined on the side of the placement plate 521 away from the guide plate 51. The rack body 53 can be placed in the placement slot 5211, with a number of tips 531 neatly arranged within the rack body 53. The entire mounting bracket 52 is located within the housing 55. A handle slot 551 is defined on one side of the housing 55 to facilitate pulling out the guide plate 51 to replace the tips 531 within the rack body 53. A notch is formed at the corresponding position between the housing 55 and the box body 53 to expose the suction tips 531 outside the housing 55, making it easier to remove the suction tips 531. The suction tip box mechanism 5 also includes a ball-shaped snap assembly 54, through which the guide plate 51 is snapped to the lower base plate 22, allowing the guide plate 51 to be detachably mounted on the lower base plate 22.

[0056] Reference Figure 2 and Figure 6 The test tube box mechanism 6 includes a screw motor assembly, a test tube holder 61 and an outer cover 62. The test tube holder 61 is slidably arranged on the lower base plate 22 through the guide rail assembly 24. The screw motor assembly is arranged on the lower base plate 22 and can drive the test tube holder 61 to slide on the lower base plate 22. The outer cover 62 is sleeved on the test tube holder 61 to protect the test tube holder 61.

[0057] Reference Figure 6 and Figure 7The test tube holder 61 is provided with two support members 614, which are arranged side by side in the test tube holder 61. The support members 614 include a support plate 6141, a support block 6142, and an elastic sheet 6413. The support plate 6141 is connected to the test tube holder 61 by screws, and the support block 6142 is connected to the support plate 6141 by screws, and the support block 6142 is arranged perpendicular to the support plate 6141. A sample test tube 611 and a centrifuge tube 612 are placed on the test tube holder 61. Two placement holes are provided on the test tube holder 61. One end of the sample test tube 611 and the centrifuge tube 612 pass through the two placement holes and abut against the two support blocks 6142 respectively. A fixed sleeve 613 is also provided on the sample test tube 611 and the centrifuge tube 612. The fixed sleeve 613 is set on the test tube holder 61. The fixed sleeve 613 is used to fix the sample test tube 611 and the centrifuge tube 612 to reduce the tilting of the sample test tube 611 and the centrifuge tube 612. An elastic sheet 6413 is provided on the side of the support block 6142 that abuts the sample tube 611 and the centrifuge tube 612. The elastic sheet 6413 is arranged parallel to the support block 6142. One side of the elastic sheet 6413 is integrally formed with the support block 6142, while the other side can move toward or away from the support block 6142. The elastic sheet 6413 primarily serves as a buffer for the sample tube 611 and the centrifuge tube 612, reducing the possibility of the sample tube 611 and the centrifuge tube 612 being broken due to collision with the support block 6142. In this embodiment, the centrifuge tube 612 is a capped test tube. To open the cap, a fixing rod 615 is also integrally formed on the test tube holder 61. One end of the fixing rod 615 is connected to the test tube holder 61, and the other end is a bent end. Open the cover of the centrifuge tube 612 so that the cover is located at the bent position of the fixing rod 615. The fixing rod 615 can limit the cover of the centrifuge tube 612 to reduce the rebound of the cover of the centrifuge tube 612 and the influence of the experimental operation.

[0058] Reference Figure 2 and Figure 8 The collecting mechanism 7 includes a fixing frame 71, a collecting box 72 and a push-button switch assembly 73. The fixing frame 71 is set on the side of the upper base plate 21 facing the lower base plate 22 by screws. The collecting box 72 is slidably set on the fixing frame 71, and the collecting box 72 is connected to the fixing frame 71 through the push-button switch assembly 73. The push-button switch assembly 73 can control the connection relationship between the collecting box 72 and the fixing frame 71.

[0059] Reference Figure 2 and Figure 9The centrifugal mechanism 4 includes a centrifugal frame 43, a sliding assembly 41, and a rotating assembly 42 disposed on the lower base plate 22. A centrifugal chip 432 is slidably disposed on the centrifugal frame 43, and the centrifugal chip 432 can perform a centrifugal operation on the sample. The sliding assembly 41 includes a sliding portion 411 and a clamping portion 412. The clamping portion 412 drives the centrifugal frame 43 to slide toward or away from the lower base plate 22. The sliding portion 411 drives the centrifugal chip 432 to slide on the centrifugal frame 43, so that the centrifugal chip 432 can slide out, so that the staff can replace the centrifugal chip 432.

[0060] Reference Figure 2 and Figure 10 The motor bracket 222 is screwed to the lower base plate 22. A sliding rod 435 is screwed to the side of the centrifugal frame 43 near the motor bracket 222. Several sliding rods 435 are parallel to each other, and four sliding rods 435 are used in this embodiment. The end of the sliding rod 435 away from the centrifugal frame 43 is slidably connected to the motor bracket 222. The end of the sliding rod 435 away from the centrifugal frame 43 passes through the motor bracket 222 and is threadedly connected to a limit nut 4352. Each sliding rod 435 is also sleeved with a buffer spring 4351. One end of the buffer spring 4351 is bonded to the centrifugal frame 43, and the other end is bonded to the motor bracket 222.

[0061] Refer to 9 and Figure 10 The clamping portion 412 includes a clamping plate 4121, a clamping motor 4122, and a clamping block 4123. The clamping plate 4121 is screwed to the lower base plate 22. The clamping motor 4122 is also screwed to the clamping plate 4121. The clamping motor 4122 is drivingly connected to a screw. The end of the screw remote from the clamping motor 4122 is rotatably connected to the clamping plate 4121. The clamping block 4123 is threadedly connected to the screw. One side of the clamping block 4123 is screwed to the centrifugal frame 43. The clamping motor 4122 can drive the centrifugal frame 43 to move toward or away from the lower base plate 22.

[0062] Reference Figure 11The sliding portion 411 includes a sliding motor 4111, a driving rod 4112, and a driving plate 4113. The sliding motor 4111 is screwed to the motor bracket 222 and is drivingly connected to one end of the driving rod 4112. The other end of the driving rod 4112 is connected to a sliding block 41121. The centrifugal frame 43 is slidably connected to a sliding frame 433 on the side away from the bottom plate. The centrifugal frame 43 is also screwed to a fixed tube 434, wherein the sliding frame 433 is slidably disposed within the fixed tube 434. One end of the driving plate 4113 is screwed to the sliding frame 433, and the driving plate 4113 can drive the sliding frame 433 to slide on the centrifugal frame 43. The driving plate 4113 is provided with a sliding groove 41131 extending along the length of the driving plate 4113. A sliding block 41121 is disposed within the sliding groove 41131 and is slidably connected to the sliding groove 41131. A reinforcing strip 4114 is also integrally formed on the driving plate 4113 and is positioned in close contact with the sliding frame 433, increasing the contact area between the driving plate 4113 and the sliding frame 433. This allows the driving plate 4113 to more stably drive the sliding frame 433 to slide on the centrifugal frame 43.

[0063] Reference Figure 11 and Figure 12 The reinforcing strip 4114 is connected to a centrifugal disc 431 on one side away from the lower base plate 22 by screws. In this embodiment, the centrifugal disc 431 adopts a semi-annular structure, and three plug-in posts 4311 are evenly arranged on the centrifugal disc 431. The centrifugal chip 432 is plugged into each plug-in post 4311, and a snap-in groove 4321 is provided in the middle of the centrifugal chip 432. In this embodiment, the snap-in groove 4321 is in the shape of a regular hexagonal structure.

[0064] Reference Figure 11 and Figure 13 The lower base plate 22 is also provided with two limit assemblies 221, which are arranged on either side of the sliding motor 4111. The limit assemblies 221 include a fixed plate 2211 and a limit block 2212. One end of the fixed plate 2211 is screwed to the lower base plate 22, and the other end is screwed to the limit block 2212. Each limit block 2212 is tilted toward the sliding motor 4111. A buffer sheet 2213 is integrally formed on the side of the limit block 2212 away from the lower base plate 22. One end of the buffer sheet 2213 is connected to the limit block 2212, and the other end can move toward or away from the limit block 2212. The side of the buffer sheet 2213 away from the limit block 2212 abuts against the drive rod 4112.

[0065] Reference Figure 9 and Figure 14The rotating assembly 42 includes a rotating motor 421 and a rotating frame 423. The rotating frame 423 is screwed to the lower base plate 22, and the entire rotating frame 423 is located within the centrifugal frame 43. The rotating motor 421 is screwed to the rotating frame 423, and the output shaft of the rotating motor 421 passes through the rotating frame 423 and is threadedly connected to a rotating column 422. The end of the rotating column 422 away from the rotating motor 421 is screwed to a clamping block 4221. The rotating column 422 is also sleeved with a limit plate 4222 and a baffle 4223. The limit plate 4222 is located between the baffle 4223 and the clamping block 4221, and the limit plate 4222 is arranged in a close fit with the clamping block 4221. The cross-section of the limit plate 4222 is larger than the cross-section of the clamping block 4221. A plurality of stoppers 4231 are provided on the side of the rotating frame 423 facing the engaging block 4221. In this embodiment, three stoppers 4231 are used, evenly spaced on the rotating frame 423. Each stopper 4231 has a stopper slot 42311 defined on the side facing the rotating rod, with the edge of the baffle 4223 positioned within the stopper slot 42311.

[0066] The implementation principle of the fully automatic sample adder in the embodiment of the present application is as follows: when sample addition is required, the staff first pulls out the tip box mechanism 5 from the casing 1, places the box body 53 filled with tips 531 on the mounting bracket 52, and then pushes the tip box mechanism 5 into the casing 1; the screw motor assembly of the test tube box mechanism 6 is started to drive the test tube bracket 61 to slide out, and the staff puts the centrifuge tube 612 and the sample test tube 611 filled with sample liquid into the test tube bracket 61, and then the screw motor assembly drives the test tube bracket 61 to return to its position; then, the moving component 31 is started to drive the suction head 531 connector to move to the top of the box body 53, and then the driving motor 322 drives the suction head connecting rod 331 to approach the suction head 531 until one end of the suction head connecting rod 331 is plugged into the suction head 531, and the driving motor 322 drives the suction head connecting rod 331 to return to its position ; Then the moving component 31 drives the suction head 531 to move above the test tube box mechanism 6, the driving motor 322 drives the suction head 531 to be inserted into the sample chamber tube, the air pump 332 is started, the sample liquid is sucked into the suction head 531, and then the driving motor 322 drives the suction head 531 to return to its original position; then the moving component 31 drives the suction head 531 to move above the centrifugal mechanism 4, the driving motor 322 drives the suction head 531 to approach the centrifugal chip 432, and then the air pump 332 is started to discharge the sample liquid in the suction head 531 into the centrifugal chip 432, and the driving motor 322 drives the suction head 531 to return to its original position; then the clamping motor 4122 is started to drive the centrifugal frame 43 to move in the direction close to the lower bottom plate 22 until the centrifugal chip 432 is clamped with the clamping block 4221, and then the rotating motor 421 drives the centrifugal chip 432 to rotate, and the sample liquid is centrifuged.After centrifugation is completed, the clamping motor 4122 drives the centrifugal frame 43 to bring the centrifugal chip 432 back to its original position; then the driving motor 322 continues to drive the suction head 531 to move toward the centrifugal chip 432 to suck the centrifuged sample liquid, and then the moving component 31 drives the suction head 531 to move above the test tube box mechanism 6 to discharge the sample liquid in the suction head 531 into the centrifuge tube 612; then the moving component 31 drives the suction head 531 to move into the collecting mechanism 7, and the driving motor 322 is started again to drive the suction head connecting rod 331 to move in the direction close to the limiting column 34211 until the first support plate 3411 abuts against the limiting column 34211, and the driving motor 322 continues to drive the suction head connecting rod 331 to move. At this time, the support rod 3413 will slide relative to the mounting plate 321, and the supporting spring 34131 will be compressed. At the same time, the second support plate 341 When the centrifugal chip 432 needs to be replaced, the sliding motor 4111 drives the driving rod 4112 to rotate, and the sliding block 41121 of the driving rod 4112 slides in the sliding groove 41131 of the driving plate 4113. Due to the limiting effect of the fixed tube 434, the sliding frame 433 will not move in the direction away from the centrifugal frame 43, and the sliding frame 433 can only slide on the centrifugal frame 43 along the length direction of the fixed tube 434. The sliding frame 433 will drive the centrifugal chip 432 to slide out of the casing 1, so that the staff can replace the centrifugal chip 432. Then the sliding motor 4111 drives the sliding frame 433 to return to its original position.

[0067] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A fully automatic sample loading instrument, comprising a housing (1) and a main frame (2), wherein the main frame (2) is located inside the housing (1), and is characterized in that: The invention comprises a centrifugal mechanism (4), a sample loading mechanism (3), a suction tip box mechanism (5), a collecting mechanism (7) and a test tube box mechanism (6) which are arranged on a main frame (2); the sample loading mechanism (3) is slidably arranged on the main frame (2), and the centrifugal mechanism (4), the suction tip box mechanism (5), the collecting mechanism (7) and the test tube box mechanism (6) are all located within the travel range of the sample loading mechanism (3); a suction tip (531) is placed in the suction tip box mechanism (5), and a sample test tube (611) and a centrifuge tube (612) are placed in the test tube box mechanism (6); The centrifugal mechanism (4) includes a sliding assembly (41), a rotating assembly (42) and a centrifugal disc (431), wherein the centrifugal disc (431) is slidably arranged on the main frame (2), and a centrifugal chip (432) is detachably connected to the centrifugal disc (431), and the sliding assembly (41) includes a clamping portion (412) and a sliding portion (411), wherein the clamping portion (412) is used to drive the centrifugal chip (432) to approach or move away from the rotating assembly (42), so that the rotating assembly (42) drives the centrifugal chip (432) to rotate, thereby centrifuging the sample; the sliding portion (411) is used to drive the centrifugal disc (431) to slide on the main frame (2), and a clearance opening (11) is provided on the casing (1), and the centrifugal disc (431) slides in a direction away from the casing (1) through the clearance opening (11), so as to facilitate the replacement of the centrifugal chip (432); The main frame (2) includes an upper base plate (21) and a lower base plate (22) arranged in parallel, and the four corners of the upper base plate (21) and the lower base plate (22) facing each other are connected by connecting columns (23). The centrifugal mechanism (4) also includes a centrifugal frame (43), and the centrifugal frame (43) is slidably arranged on the lower base plate (22); the sliding portion (411) and the clamping portion (412) are both arranged on the lower base plate (22), and the rotating assembly (42) includes The rotary motor (421) is provided on the lower base plate (22), the rotary motor (421) is connected to a clamping block (4221) in a transmission manner, a clamping groove (4321) is provided in the middle of the centrifugal chip (432), and the clamping portion (412) is used to drive the centrifugal frame (43) to slide in a direction close to or away from the upper base plate (21), so that the clamping block (4221) is located in the clamping groove (4321) and is clamped and connected to the centrifugal disc (431); The clamping portion (412) includes a clamping plate (4121), a clamping motor (4122) and a clamping block (4123) slidably arranged on the clamping plate (4121); the clamping plate (4121) is arranged on the lower base plate (22); the clamping motor (4122) is arranged on the clamping plate (4121) and is used to drive the clamping block (4123) to slide on the clamping plate (4121); the clamping block (4123) is connected to the centrifugal frame (43); the clamping block (4123) drives the centrifugal frame (43) to slide in a direction close to or away from the upper base plate (21), thereby realizing the clamping or disengagement of the centrifugal chip (432) and the clamping block (4221).

2. The fully automatic sample dispenser according to claim 1, wherein: The sliding portion (411) includes a sliding motor (4111), a driving rod (4112) and a driving plate (4113). The sliding motor (4111) is arranged on the lower base plate (22) and is in transmission connection with the driving rod (4112). A sliding frame (433) is slidingly arranged on the centrifugal frame (43). The driving plate (4113) is connected to the sliding frame (433). A sliding groove (41131) is provided on the driving plate (4113), and the opening direction of the sliding groove (41131) is consistent with the sliding direction of the block (4123). A sliding block (41121) is provided at one end of the driving rod (4112) away from the sliding motor (4111), and the sliding block (41121) is slidingly arranged in the sliding groove (41131). The sliding motor (4111) drives the sliding block (41131) to rotate. 121) slides in the sliding groove (41131), thereby driving the sliding frame (433) to drive the centrifugal disc (431) to slide on the centrifugal frame (43), and the sliding direction is the direction of approaching or moving away from the yielding opening (11); a limiting assembly (221) is further provided on the lower bottom plate (22), the number of the limiting assemblies (221) is two, and the two limiting assemblies (221) are arranged on both sides of the sliding motor (4111), the limiting assembly (221) includes a fixed plate (2211) and a limiting block (2212), the fixed plate (2211) is arranged on the lower bottom plate (22), the limiting block (2212) is arranged on the fixed plate (2211), and the two limiting blocks (2212) are inclined toward the direction of the sliding motor (4111), and the driving rod (4112) abuts against the limiting block (2212).

3. The fully automatic sample loading instrument according to claim 1, wherein: The rotating assembly (42) further comprises a rotating frame (423), the rotating frame (423) being arranged on the lower bottom plate (22) and located in the centrifugal frame (43), the rotating motor (421) being arranged on the rotating frame (423), the output shaft of the rotating motor (421) passing through the rotating frame (423) and being transmission-connected to a rotating column (422), the end of the rotating column (422) away from the rotating motor (421) being connected to a clamping block (4221), the rotating column (422) being further sleeved with a limiting plate (4222) and a baffle (4223), the baffle (4223) being close to the rotating frame (423) and the baffle (4223). ) direction, the limiting plate (4222) is arranged between the baffle (4223) and the clamping block (4221), and the cross section of the limiting plate (4222) is larger than the cross section of the clamping block (4221), and the side of the limiting plate (4222) away from the baffle (4223) abuts against the centrifugal chip (432); a number of limiting members (4231) are provided on the rotating frame (423), and a limiting groove (42311) is provided on the plurality of limiting members (4231), and the edge of the baffle (4223) is located in the limiting groove (42311) of each limiting member (4231).

4. The fully automatic sample dispenser according to claim 1, wherein: A plurality of sliding rods (435) are connected to one side of the centrifugal frame (43) close to the lower base plate (22), and each of the sliding rods (435) is parallel to each other. One end of the sliding rod (435) is connected to the centrifugal frame (43), and the other end is slidably connected to the lower base plate (22). Each of the sliding rods (435) is sleeved with a buffer spring (4351), and one side of the buffer spring (4351) is connected to the centrifugal frame (43), and the other side is connected to the lower base plate (22).

5. The fully automatic sample dispenser according to claim 1, wherein: The suction head box mechanism (5) comprises a guide plate (51), a mounting bracket (52), a box body (53) and a ball buckle assembly (54); the guide plate (51) is slidably arranged on the main frame (2); the mounting bracket (52) is arranged on the guide plate (51); the box body (53) is detachably arranged on the mounting bracket (52); the number of the suction heads (531) is several and is placed in the box body (53); the ball buckle assembly (54) is used to detachably connect the guide plate (51) to the main frame (2).

6. The fully automatic sample dispenser according to claim 1, characterized in that: The test tube box mechanism (6) comprises a screw motor assembly and a test tube support (61) arranged on the main frame (2); the test tube support (61) is slidably arranged on the main frame (2); the sample test tube (611) and the centrifuge tube (612) are detachably arranged on the test tube support (61); and the screw motor assembly is used to drive the test tube support (61) to slide on the main frame (2).

7. The fully automatic sample dispenser according to claim 1, wherein: The collecting mechanism (7) comprises a connecting frame (3422), a collecting box (72) and a push-button switch assembly (73); the collecting box (72) is slidably arranged on the connecting frame (3422) and is used for collecting the suction heads (531); the push-button switch assembly (73) is arranged on the connecting frame (3422) and is used for detachably detaching the collecting box (72) and setting it on the main frame (2).

8. The fully automatic sample dispenser according to claim 1, wherein: The loading mechanism (3) comprises a moving assembly (31), a driving assembly (32), a gun head assembly (33), a disassembly assembly (34) and a mounting frame (35) slidably arranged on the main frame (2); the moving assembly (31) is arranged on the main frame (2) and is used to drive the mounting frame (35) to slide on the main frame (2); the driving assembly (32), the gun head assembly (33) and the disassembly assembly (34) are all arranged on the mounting frame (35); the driving assembly (32) comprises a mounting plate (321) and a driving motor (322) arranged on the mounting frame (35); the driving motor (322) is used to drive the mounting plate (321) to slide on the machine body, and the gun head assembly (33) includes a suction head connecting rod (331) and an air pump (332), the suction head connecting rod (331) is arranged on the mounting plate (321), and the end of the suction head connecting rod (331) away from the mounting plate (321) is detachably connected to the suction head (531), the air pump (332) is arranged on the mounting frame (35), and is used to drive the suction head (531) to suck or discharge samples, and the disassembly assembly (34) is arranged on the mounting frame (35) and is used to automatically disassemble the suction head (531).

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