A medical mixing device and system

Abstract

The application discloses a medical mixing device and system, which comprises a liquid container containing liquid to be mixed, a bearing part and a liquid container motion driving device; the bearing part bears at least one liquid container; the liquid container motion driving device is used for driving the liquid container to rotate to realize liquid mixing under rotation; the application can generate the rotation of the liquid container through the liquid container motion driving device, and can realize the provision of the medical mixing device with composite requirements of turbulent degree through two-stage rotation speed lifting structures configured by the transmission structure, so that the conditions of meeting the mixing are ensured, and problems such as pollution or foreign matter falling off to cause unreliable system operation are avoided.

Description

Technical Field

[0001] This invention relates to the field of medical technology, and in particular to a medical mixing device and system. Background Technology

[0002] In real-world production and daily life, many scenarios require mixing different liquids, including liquids containing solids, or different liquids and solids. This is also very common in medical settings. Compared to other scenarios, medical settings have specific requirements for mixing. For example, the medical industry demands high mixing efficiency because it involves many steps in different processes. Therefore, efficient operation of each step helps shorten the overall process time, thus greatly reducing the possibility of biological contamination. To meet these requirements, different companies have developed high-speed rotating equipment for mixing and centrifugation. However, these devices typically have high requirements for the drive motor and are mostly stand-alone units, which are not suitable for automated, systematic design layouts.

[0003] To meet the liquid mixing requirements in automated system design, more and more manufacturers have implemented improved designs. International application WO2014002954A1 proposes a design that uses a motor to drive a rotating wheel, which in turn drives the container through an eccentrically designed rotating drive unit that contacts the bottom of the liquid container. This causes the reaction container to rotate and twist slightly. However, this design has a significant problem: the rotation speed cannot be too high, as the centrifugal force may cause the container to detach from the drive unit. Japanese patent application JP6332448B2 also uses a similar design. To prevent the drive unit from acting directly on the liquid container, it incorporates a spring-loaded support structure, avoiding special requirements for the liquid container design. However, this design also cannot solve the imbalance caused by rotation that is not around the container's own axis. Additional structures are needed to balance the risk of the container being thrown out by centrifugal force in high-speed rotation scenarios, thus increasing the complexity of the design and placing certain requirements on the container's parameters (such as moment of inertia, dynamic balance performance, eccentricity, etc.). Similarly, US application US20200182754A1 also uses a similar design. Chinese patent application CN201711338006.X discloses a mixing scheme for a liquid container that incorporates both revolution and rotation. However, mixing by rotation alone causes the liquid to rotate. According to experiments conducted by professionals, this leads to a problem: due to inertia, different reagents will exhibit similar motion as the rotation time increases, resulting in less than ideal internal turbulence and affecting the mixing effect. To improve this, some have proposed using forward and reverse rotation control to create a certain degree of turbulence, similar to the rotation of a washing machine. However, this intense turbulence only occurs for a relatively short period. On the one hand, this implementation places certain requirements on the reliability of the system design; on the other hand, the average value of the generated turbulence over time may not be ideal. Furthermore, this intense turbulence in a short period can cause liquid splashing, which is not suitable for scenarios without a cap. In scenarios with a cap, a large amount of reagent may adhere to the cap, potentially causing contamination and loss of the analyte. Earlier patent documents described conventional mixing systems using mixing elements or mixing devices. The main problems with these systems included: the mixing of the mixing elements required a drive mechanism and control unit, inevitably leading to a complex device structure and increased cost of implementation. Furthermore, mixing could be incomplete due to a malfunction in the mixing element's drive mechanism. Other designs used deformable tubes to induce deformation through pressurization or depressurization for liquid mixing; however, these designs suffered from limitations in consumables, mixing effectiveness, and mixing time.

[0004] Therefore, in order to meet the special mixing needs in the medical field, there is an urgent need to develop a liquid mixing device with higher mixing efficiency and lower cost and complexity. Summary of the Invention

[0005] The purpose of this invention is to address the aforementioned problems by providing a medical mixing device and sample liquid processing system. This invention solves the problem of high risk of liquid contamination during mixing and addresses the issue of low mixing efficiency.

[0006] The technical solution adopted in this invention is as follows:

[0007] A medical mixing device includes: a liquid container containing a liquid to be mixed, a support portion, and a liquid container motion drive device; the support portion carries at least one of the liquid containers; the liquid container motion drive device is used to drive the liquid container to perform a rotational motion to achieve liquid mixing under rotational motion.

[0008] Furthermore, the liquid container motion drive device includes at least two stages of speed enhancement mechanism, motor, rotating shaft and transmission shaft. The end of the rotating shaft is connected to a transmission gear, which meshes with the transmission gear to transmit the rotational motion of the motor's central shaft to the transmission shaft. The speed enhancement mechanism adopts a transmission structure with a high number of teeth meshing with a low number of teeth.

[0009] Furthermore, the two-stage speed enhancement mechanism includes a first-stage speed enhancement mechanism and a second-stage speed enhancement mechanism; the first-stage speed enhancement mechanism includes a meshing gear, which meshes with a first meshing gear disposed on the intermediate shaft; the second-stage speed enhancement mechanism is located on the intermediate shaft and includes a second meshing gear, which meshes with a third meshing gear disposed at the bottom of the bearing part.

[0010] Furthermore, the gear ratio of the primary speed-enhancing mechanism and the secondary speed-enhancing mechanism is 3:1 to 10:1.

[0011] Furthermore, it also includes a support unit driving device, used to drive the support unit to drive the liquid container to perform a first motion in a manner different from the rotational motion, so as to achieve liquid mixing under the combined motion.

[0012] Furthermore, the first motion is a periodic oscillating motion with a trajectory of a cycloid.

[0013] Furthermore, the carrier includes a plurality of carrier ports, such that each carrier port can receive a corresponding liquid container.

[0014] Furthermore, the motor is a shared drive motor for both the load-bearing drive device and the liquid container drive device. The motor includes an output shaft, with both ends of the output shaft connected to the load-bearing drive device and the liquid container drive device, respectively, thereby enabling the shared motor to simultaneously provide the power source for the first motion and rotational motion.

[0015] Furthermore, one end of the output shaft is connected to the motor, and the other end is connected to the center of the wheel. One end of the connecting rod is eccentrically connected to the non-center part of the wheel, and the other end is connected to a fixed base.

[0016] A system based on the above-mentioned mixing device, wherein the system includes at least one mixing device.

[0017] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0018] 1. This invention drives the rotation of the liquid container by means of a rotation speed enhancement mechanism of no less than two stages, which can control the degree of turbulence of the liquid movement in the liquid container. This avoids the problem of excessive turbulence in the medical sample container due to only considering the mixing effect, which may lead to the shedding of foreign objects such as cotton fibers and increased risk of contamination.

[0019] 2. In the present invention, the liquid container driven by the carrier unit driving device can perform a first motion, and simultaneously, the liquid container driving device drives the liquid container to perform a rotational motion, thereby making the motion of the composite liquid container a complex composite type. This can create a more intense turbulence effect inside the liquid, thereby improving the mixing efficiency. Furthermore, the first motion is a periodic oscillating motion, and the rotational motion is preferably a rotational motion around the axis or quasi-axis of the liquid container. Using rotational motion around its own axis can prevent the container from being subjected to greater centrifugal force and can match a higher rotational speed, ensuring both mixing efficiency and the reliability of the mixing system operation.

[0020] 3. Using the same motor as the driving force for both oscillating and rotating motions simplifies the overall system design and significantly reduces the system's failure rate. The motor's output force drives the support unit to oscillate left and right around the central vertical direction, and also causes the liquid container to rotate around its axis, forming a composite motion. The left and right oscillation around the central vertical direction can be a cycloidal swing motion. This achieves a complex combination of rotation and oscillation motions driven by the same power source, increasing the turbulence of the liquid within the container and preventing unacceptably severe turbulence from concentrating in certain time periods, thus better meeting the needs of medical applications.

[0021] 4. Furthermore, the two ends of the output shaft of the shared motor are directly or indirectly connected to the load-bearing drive device and the liquid container drive device, respectively. This achieves the use of the same motor to output composite motion, and the different motions output at both ends do not interfere with each other, ensuring the reliability of the module operation. Furthermore, the rotational motion is transmitted by gear meshing, and the oscillating motion is transmitted and converted by the eccentric wheel connecting rod transmission structure. The combination of these two mechanical transmissions ensures the simplicity and reliability of the system.

[0022] 5. By using at least two stages of gear meshing with high-tooth-count and low-tooth-count gears, a speed-increasing structure is formed to meet the rotational speed of its own rotational motion. The high-speed rotational motion is combined with the oscillating motion of the cycloidal trajectory with a low oscillation frequency to generate more reasonable internal turbulence of the liquid to ensure stirring efficiency. On the other hand, it does not cause excessive turbulence. Furthermore, when the drive motor drives the liquid container to complete one oscillation stroke, it can achieve the effect of better stirring efficiency and better turbulence level.

[0023] 6. The system of the present invention using a mixing device can achieve both low pollution risk and high efficiency detection under the premise of high automation. In order to ensure the high efficiency of system operation, no less than two of the mixing devices can be set in each system. Of course, the timing and swing direction can be controlled to prevent mutual interference between the multiple mixing devices during operation. Attached Figure Description

[0024] The present invention will be described by way of example and with reference to the accompanying drawings, wherein:

[0025] Figure 1 This is a schematic diagram of the mixing device structure in Example 1;

[0026] Figure 2 This is a side view of the mixing device in Example 1;

[0027] Figure 3 This is a schematic diagram of the mixing device structure in Example 2;

[0028] Figure 4 This is a schematic diagram of the mixing device in Example 2, which includes a liquid container.

[0029] Figure 5 This is a rear view of the mixing device in Example 2;

[0030] Figure 6 This is a schematic diagram of the mixing device in Example 2, which includes a liquid container.

[0031] Figure 7 This is a schematic diagram of the mixing device in Example 2, showing the carrier section moving the liquid container to one of the positions.

[0032] Figure 8 This is a schematic diagram of the mixing device carrier in Example 2 moving the liquid container to another position;

[0033] Figure 9 This is a schematic diagram of the simultaneous rotation of liquid containers at different positions of the mixing device support in Example 2.

[0034] Figure 10 This is a schematic diagram of the combined motion of the liquid container of the mixing device in Example 2, which involves rotation around its own axis and oscillation of a cycloidal trajectory.

[0035] Figure 11 This is a schematic diagram showing the simultaneous rotation of liquid containers at different positions on the support of the mixing device in the scenario where more liquid containers are provided on the support of the mixing device in Example 2.

[0036] Figure 12 This is a schematic diagram of the rotational motion output transmission of the mixing device in Example 3;

[0037] Figure 13 This is a schematic diagram of a liquid container;

[0038] Figure 14 This is a schematic diagram of the structure of Example 4, which includes two mixing modules.

[0039] The components include: a bearing unit-10; a motor-11; a rotating shaft-301; a transmission shaft-302; a transmission gear-301a; a transmission gear-302a; a first meshing gear-302b; an intermediate shaft-303; a second meshing gear-303a; a third meshing gear-303b; a fourth meshing gear-304a; a bearing port-101; a liquid container-401; an output shaft-201; a rotating wheel-202; a connecting rod-203; a clamping structure-501; a pipe body-401a; a cap-401b; a convex rib structure-4011; and a second drive motor-210. Detailed Implementation

[0040] All features disclosed in this specification, or all steps in all disclosed methods or processes, may be combined in any way, except for mutually exclusive features and / or steps.

[0041] Any feature disclosed in this specification (including any appended claims and abstract) may be replaced by other equivalent or similar features, unless specifically stated otherwise. That is, unless specifically stated otherwise, each feature is merely one example of a series of equivalent or similar features.

[0042] In medical applications, there is an increasing need to mix liquids by stirring, oscillating, etc. On the one hand, the medical field requires a certain level of thorough mixing; on the other hand, excessive turbulence can cause damage, contamination, and other problems, which can affect the accuracy of the results. Current designs mainly suffer from the following problems: 1) Multi-motor composite motion schemes are costly, complex in design, and have a higher failure rate; 2) Single-motor single-motion schemes cannot overcome the low turbulence and poor mixing efficiency inherent in single-type motions; 3) Single-motor schemes similar to celestial rotation and revolution can improve mixing efficiency to some extent, but the sample liquid may exhibit dynamic equilibrium, making it impossible to generate continuous turbulence to maximize mixing efficiency; 4) Complex motion designs where the sample tube does not rotate around its own axis require complex balancing structures to prevent the container from being thrown out at high speeds due to centrifugal force. Therefore, this invention addresses the above-mentioned problems of existing designs by designing a low-cost, simple, highly efficient, and reliable mixing device.

[0043] Example 1

[0044] A medical mixing device includes: a liquid container 401 containing a liquid to be mixed, a support part 10, and a liquid container motion driving device; the support part 10 supports at least one of the liquid containers 401; the liquid container motion driving device is used to drive the liquid container 401 to perform a rotational motion to achieve liquid mixing under rotational motion.

[0045] like Figure 1 and Figure 2 As shown, motor 11 serves as the power source for the rotary motion drive device, outputting rotary motion via rotary shaft 301. It is directly or indirectly connected to the liquid container motion drive device. One end of rotary shaft 301 is connected to a transmission gear 301a, which meshes with a drive gear 302a. This drive gear 302a can transmit the rotary motion of the central shaft of motor 11 to drive shaft 302. In this embodiment, the two meshing gears are optimally designed with the same or similar gears with the same number of teeth and the same module to ensure the reliability of gear transmission. Drive shaft 302 is connected to a speed enhancement device to adjust the speed to a suitable range. The speed enhancement device includes a two-stage speed enhancement structure. Both stages of the speed enhancement structure adopt a high-tooth-number meshing low-tooth-number transmission configuration. Of course, in some scenarios, a two-stage pulley transmission mechanism can also be used as the two-stage speed enhancement structure. The specific implementation method is not limited here.

[0046] The other end of the drive shaft 302 is connected to the first meshing gear 302b of the first-stage speed-enhancing mechanism, which meshes with the second meshing gear 303a configured on the intermediate shaft 303. To ensure the speed-enhancing effect of the first-stage transmission, the gear ratio of this meshing gear pair is set to 120:20. Of course, other ratios and gear ratios can be used according to design requirements, such as satisfying a simplified gear ratio range of 3:1 to 10:1 (the speed-enhancing ratio range can be similar when using a pulley design). This is not limited here; the gear ratio can be optimized according to system reliability and transmission efficiency requirements. In this way, the intermediate shaft 303 will obtain a relatively high speed through the speed-enhancing effect of the first-stage transmission. At this time, the third meshing gear 303b of the second-stage speed-enhancing mechanism can be set at another position on the intermediate shaft 303, combined with... Figure 2 The third meshing gear 303b can mesh with the fourth meshing gear 304a provided at the bottom of the bearing part 10, further increasing the speed of the intermediate shaft 303's relatively high-speed motion. This constitutes the entire liquid container motion drive device, and also realizes the effect of converting the rotational motion output by the motor 11 shaft into the high-speed rotational motion of the liquid container 401. In order to meet the design requirements, the gear ratio of the meshing gear pair of the second-stage speed enhancement mechanism is set to 80:20. Of course, other ratios and gear ratios can be used according to design requirements, such as satisfying the simplified ratio within the range of 3:1 to 10:1. Furthermore, in order to adapt to the requirements of transmission reliability and structural compactness, the gear ratio of the meshing gear pair of the second-stage speed enhancement mechanism is optimally set to be less than the gear ratio of the meshing gear pair of the first-stage speed enhancement structure.

[0047] To ensure better fixation of the liquid container 401, the support platform also includes a clamping structure 501, which can be an elastic clamping structure. The specific implementation is not limited here. The liquid container 401 is driven by the liquid container motion drive device to perform a rotational motion. The axis of this rotation can be the central axis or near-central axis of the container, or it can be an eccentric rotation with a predetermined angle to the central axis. A special type of rotation scheme with a bottom eccentricity and a fixed center can also be used. In this case, the clamping structure 501 needs to ensure reliable clamping. The optimal rotational motion is a rotational motion with the axis or near-axis of the liquid container 401 as the central axis. This ensures a simple design for the clamping structure 501 and higher system reliability. In other embodiments, more meshing gears can be configured to achieve the effect of simultaneously mixing more liquid on the support platform. Furthermore, in some special cases, more stages of speed-increasing mechanisms can be set up, which is also not limited here.

[0048] The solution provided in this embodiment can achieve the mixing of sample liquid in liquid container 401 according to a preset degree of turbulence, so as not to generate excessive turbulence.

[0049] Example 2

[0050] Example 2 is similar in structure to Example 1, except that it also includes a support unit driving device, which drives the support unit 10 to drive the liquid container 401 to perform a first motion in a manner different from the rotational motion, so as to achieve liquid mixing under the combined motion.

[0051] like Figure 3 and Figure 4 As shown, motor 11 is used to output the driving force of the liquid container motion drive device and the load-bearing part drive device. In this embodiment, motor 11 is a power source shared by the two types of motion. Different mechanisms are connected to the two ends of the central shaft to ensure that the power of the two motions is output without interference. Both of the connected mechanisms adopt mechanical transmission to reduce the failure rate. The entire design only requires one motor 11 to realize the high reliability of the two different motion power output devices, with lower design complexity and lower cost.

[0052] The figure shows a rotary motion drive device connected to one end of the central shaft of the motor 11. The output shaft 201 of the motor 11 includes an output gear element that meshes with a gear at the end of the transmission shaft 302. The rotation of the motor 11 is transmitted to the transmission shaft 302 through the meshing gear pair. The transmission shaft 302 is further connected to a speed enhancement mechanism, which converts the rotary motion of the motor 11 into the rotary motion of the bottom of the bearing port 101 on the bearing part 10. This results in the self-rotation motion driven by the liquid container 401 driven by the motor 11.

[0053] Its carrier part 10 includes two carrier ports 101, so that each carrier port 101 can receive a corresponding liquid container 401. The liquid container 401 can be a sample tube for collection, such as a throat swab, nasal swab, anal swab, etc., a whole blood sample tube, a magnetic bead suspended sample container, a PCR amplification reagent premixing tube, etc., and is not limited to any specific type. It can be used in any application scenario that requires automated liquid mixing. Figure 13 As shown, to ensure the system's high efficiency, the sampling tube body 401a typically includes identification labels such as barcodes and QR codes, along with a matching cap 401b. During the mixing process of complex motions, the cap 401b is tightly connected to the tube body 401a to prevent contamination. The bottom of the sampling tube has a raised rib structure 4011, which ensures that the sampling tube body, undergoing complex motions within the support section 10, does not experience relative movement. The label on the tube body 401a will not shift relative to the tube, and slippage will not occur, preventing insufficient liquid mixing. The stability of the label also contributes to the accurate information control and identification of the automated system.

[0054] like Figure 5 and Figure 6 As shown, the other end of the central output shaft 201 of the motor 11 is connected to the center of the wheel 202. One end of the connecting rod 203 is eccentrically connected to the non-central part of the wheel 202, and the other end is connected to the fixed base. In this embodiment, the motor 11 is a shared drive motor for both the bearing drive device and the liquid container 401 drive device. The shared motor 11 is fixedly connected to the bearing 10. Under this design, when the central shaft of the motor 11 rotates, the wheel 202 will be driven to move. Under the action of the eccentrically set connecting rod 203, the motor 11 drives the entire bearing platform to swing around the vertical center position with a certain amplitude. This swing can be an approximately cycloidal oscillation motion. That is, the first type of oscillation motion driven by the shared motor 11 to the bearing 10 is realized through the eccentric wheel connecting rod 203 structure. Of course, in order to achieve the composite requirements of oscillation amplitude and ensure the strength and reliability of the system, the following measures are taken. In this design, the distance between the center of the connecting rod 203 and the center of the motor 11 is between 1 / 2 and 3 / 4 of the radius of the rotating wheel 202. This design means that during the rotation of the shared motor 11, it is equivalent to simultaneously outputting a composite motion of oscillation and rotation to the liquid container 401 at different times. This can achieve a better mixing effect by utilizing the turbulence generated by the complex motion. At the same time, the combination of rotation and oscillation occurs within any rotation period of the motor 11, so the turbulence-enhanced mixing effect is always present, thus overcoming the problems such as liquid loss or contamination that may be caused by introducing instantaneous violent turbulence. In addition, in some scenarios, such as in sample tubes where cotton swabs are used as sampling tools, violent turbulence may cause fibers to fall into the liquid. Instruments used in the medical field have particularly high requirements for cleanliness, and fibers may cause system damage.

[0055] In other embodiments, the driving forces for both types of motion can be located at the same end of the central shaft of the common motor 11, which is not limited here. Other structures can also be used to implement the oscillating motion scheme of the bearing portion 10 output by the common motor 11. The oscillating motion is not limited to the cycloidal motion exemplified here; it can be the up-and-down oscillating motion of the bearing portion 10. For example, a cam-linkage 203 structure can be used to convert it into up-and-down oscillating motion, or it can be oscillating motion with the left and right sides on the same horizontal plane. The amplitude of this oscillating motion can be a quasi-undamped constant-amplitude oscillation or a damped non-constant-amplitude oscillation, which is not limited here. The oscillation period is optimally designed as a constant-period oscillation, for example… Figure 5 The structure is a constant-amplitude, constant-period oscillation, and the trajectory is basically cycloidal. This invention combines oscillating motion and rotational motion to form a composite type of motion, enabling sufficient turbulence to be generated within a rotating container using completely different types of oscillating motion, thereby ensuring that the liquid can be more efficiently and fully mixed in this composite type of motion.

[0056] Under the rotation of the common motor 11, the rotational motion of the motor 11 is converted into the oscillating motion of the bearing platform through the eccentric wheel connecting rod 203 mechanism. The bearing platform also drives the liquid container 401 located inside the bearing port 101 to oscillate left and right around the center vertical direction. More specifically, the trajectory of this oscillating motion is a cycloid.

[0057] like Figure 7 and Figure 8 As shown, driven by the common motor 11, the eccentric wheel linkage 203 mechanism serves as the drive device for the bearing part 10 to oscillate around the central vertical position. At this time, under the action of the drive device, it moves to a non-central position. The motion trajectory of this design is a cycloidal design, so the entire bearing platform is tilted at this position. The other end of the common motor 11 can transmit the rotational motion to the bottom end of the bearing port 101 through the meshing gear, forming the rotational motion of the liquid container 401's own axis.

[0058] In actual use Figure 7 and Figure 8 This can be a schematic diagram of two extreme positions where the oscillating motion deviates from the vertical direction of the center. The actual oscillating process can proceed from the vertical direction of the center towards... Figure 7 After the position swing motion, then by Figure 7 Position swing to Figure 8 The oscillation cycle is completed by moving the oscillation to the center position and then back to the center position. Multiple oscillation cycles can be set to achieve a thorough mixing effect. Of course, the oscillation direction can also be opposite to that described above. There is no specific limitation on the oscillation implementation scheme here.

[0059] like Figure 9-11 As shown in the figure, the bearing part 10 oscillates left and right around the central vertical line in a cycloidal trajectory under the action of the bearing part drive device. For example, it can swing to the right from the central position to the maximum amplitude position, and then swing back to the central vertical direction. As the common motor 11 continues to rotate, the bearing part 10 will continue to swing to the left to the maximum amplitude position, and then return to the central axis position to complete one oscillation cycle. In actual use, multiple oscillation cycles can be set to ensure the mixing effect, or half an oscillation cycle can be set so that the final stopping position of the bearing part 10 is at the central axis position. For example, the total oscillation cycle can be set to 1.5, 2.5, 3.5, etc.

[0060] During this oscillation process, the liquid container motion drive device drives the reagent container to rotate around its own axis, so that the liquid container 401 on the support platform can achieve complex composite motion, thus achieving more efficient mixing of the liquid in the liquid container 401.

[0061] During the mixing period, the shared motor 11 does not need to be set to reverse rotation to realize the left and right oscillating motion of the bearing part 10 around the central axis. At the same time, the bearing part drive device will not produce alternating forward and reverse rotation, which will cause violent instantaneous turbulence inside the container. It also avoids the risk of being thrown out due to excessive rotational inertia acting on the liquid container 401 caused by instantaneous change of rotation direction. In this way, the liquid turbulence is basically consistent throughout the mixing cycle.

[0062] The liquid container motion drive device can drive the liquid container 401 to rotate in the same counterclockwise direction. Alternatively, different liquid containers 401 can rotate in opposite directions via gear conversion; this is not limited to this. Simultaneously, the support unit 10 drives the liquid container 401 to perform a cycloidal oscillating motion around the center direction, such as... Figure 9 As shown in trajectory type I, of course, here the bearing part 10 can be made to oscillate left and right around the center on the same horizontal plane by changing the transmission structure design, such as... Figure 9 As shown in trajectory type II, the transmission design type can also be changed here, for example, by using a cam link 203 structure so that the entire platform can move along... Figure 9 Type III motion, characterized by oscillating trajectory lines, is not limited to this type.

[0063] Combination Figure 10 Alternatively, two different liquid containers 401 can rotate in the same clockwise direction, while the supporting part 10 drives the liquid container 401 to oscillate around the center in a cycloidal trajectory.

[0064] Figure 11 This illustrates another arrangement scheme, where the support platform can be equipped with more liquid containers 401, thereby achieving higher mixing efficiency. Of course, more liquid containers 401 can be arranged in a straight line, in a polygonal distribution, or based on a circle of a certain diameter, etc. In the arrangement of multiple liquid containers 401, every two containers can be arranged at equal intervals or at equal angles, or they can be arranged at unequal intervals or at unequal angles. This is not limited here.

[0065] Example 3

[0066] Example 3 is structurally similar to Examples 1-2, except that the motor 11 serves as a shared power source for both the liquid container motion drive device and the support unit drive device, outputting rotational motion via the rotating shaft 301. Figure 12 As shown.

[0067] In this embodiment, the central shaft has two ends, which are directly or indirectly connected to the liquid container motion drive device and the carrier drive device, respectively. The rotational motion drive principle of the liquid container 401 is similar to that in Embodiment 1. The other end of the central shaft is connected to the rotating wheel 202. The eccentric wheel connecting rod 203 structure drives the carrier platform to oscillate around the central axis. This achieves the complex composite motion of the liquid container 401 driven by the common motor 11. In order to meet the specific turbulence and achieve efficient mixing without causing damage or contamination to the object, the carrier 10 drives the liquid container 401 to complete one oscillation stroke, and the liquid container 401 completes 15-35 rotations around its axis. For example, in the implementation, it can be designed that the liquid container 401 rotates 24 times around its axis to complete one oscillation cycle.

[0068] Although accelerated by the speed-increasing device, since the rotation design of this embodiment is around its own central axis, even at high speeds, there is no need to set up a complex stabilizing device to fix it, thus preventing the risk of the container being thrown out by centrifugal force.

[0069] Example 4

[0070] Example 4 is a technical solution for packaging multiple mixing modules, which includes a combination of two mixing modules. The two mixing modules are independently driven by corresponding motors 11 via pulleys, such as... Figure 14 As shown.

[0071] After the transfer robotic arm or a person places the sample tube into the corresponding carrier port 101 of the carrier part 10, the second drive motor 210 drives the second mixing module to transfer to another position via the pulley. During the transfer process, the mixing motion driven by the shared motor 11 can be accompanied simultaneously to achieve efficient mixing design. Of course, the mixing work sequence can also be arranged after reaching the predetermined position. This is not limited here. The first mixing module can arrange its mixing sequence within at least part of the working time of the second mixing module or after the mixing is completed. The steps of the two are similar. Of course, during the parallel operation of multiple mixing modules, the timing and / or some mechanical structure settings can be used to ensure that there is no mutual interference between the modules.

[0072] In practical applications, the system is not limited to the structure shown in the attached diagram, which includes two mixing modules. More parallel mixing modules can be set up to ensure the high efficiency of the entire system's processing capacity.

[0073] Finally, in some nucleic acid testing sample processing systems, some automated whole blood sample processing systems, and even some fully automated flow systems, the medical mixing device proposed in this invention can, on the one hand, ensure sufficient agitation of the sample solution before various types of testing and diagnostic experiments to guarantee that the sample solution contains sufficient target detection objects; on the other hand, this mixing device can also facilitate the transfer of sample solutions between system modules, thus combining transfer and agitation mixing to achieve high-efficiency operation of the automated system. Of course, in other automated systems, the composite motion mixing device designed in this invention can be used in various other ways to achieve various functions.

[0074] This invention uses at least two stages of rotational speed enhancement mechanisms to drive the rotational motion of the liquid container 401, thereby controlling the degree of turbulence in the liquid movement within the liquid container 401. This avoids excessive turbulence within the medical sample container, which could lead to the shedding of foreign matter such as cotton fibers and increased contamination risk, if only the mixing effect is considered. In this invention, the liquid container 401, driven by the bearing unit driving device, can perform a first motion, while the liquid container 401 driving device simultaneously drives the liquid container 401 to rotate, resulting in a complex composite motion of the liquid container 401 after mixing. This creates a more intense turbulent effect inside the liquid, thereby improving the mixing efficiency.

[0075] Furthermore, the first motion is a periodic oscillating motion, and the rotational motion is preferably a rotational motion around the axis or a similar axis of the liquid container 401. Using rotational motion around its own axis can prevent the container from being subjected to greater centrifugal force and can match a higher rotational speed, ensuring both mixing efficiency and the reliability of the mixing system operation. Using the same motor 11 as the driving force for the oscillating motion and the rotational motion can make the design of the entire system simpler and greatly reduce the failure rate of the entire system.

[0076] The driving force output by motor 11 is used to drive the support unit 10 to oscillate left and right around the central vertical direction, and to make the liquid container 401 rotate around its axis, thus forming a compound motion. The left and right oscillation motion around the central vertical direction can be a cycloidal swing motion. This achieves a complex combination of rotation and swing motion of the liquid container 401 driven by the same power source, increasing the turbulence of the liquid in the container, and preventing the turbulence from being concentrated in certain time periods and causing unacceptably severe turbulence, thus better adapting to the needs of medical applications. The two ends of the output shaft 201 of the shared motor 11 are directly or indirectly connected to the drive device of the support unit and the drive device of the liquid container 401, thus achieving a compound motion of the same motor 11 output. The combined motion, with different output motions at both ends, ensures the reliability of the module's operation by preventing interference between the drives. Furthermore, it relies on gear meshing to transmit rotational motion and on the eccentric wheel connecting rod 203 transmission structure to transmit and convert oscillating motion. This combination of mechanical transmission ensures the simplicity and reliability of the system. At least two stages of high-tooth-count gear meshing with low-tooth-count gears form a speed-increasing structure, thus meeting the rotational speed requirements. The system primarily uses high-speed rotational motion combined with a low-frequency cycloidal trajectory oscillation motion, generating more reasonable internal turbulence in the liquid to ensure stirring efficiency. On the other hand, it avoids causing excessive turbulence. Furthermore, when the drive motor 11 drives the liquid container 401 to complete one oscillation stroke, it achieves a better stirring efficiency while maintaining a better degree of turbulence.

[0077] This invention can achieve both low pollution risk and high efficiency detection under the premise of high automation. In order to ensure the high efficiency of system operation, no less than two of these mixing devices can be set in each system. Of course, the timing and swing direction can be controlled to prevent mutual interference between the multiple mixing devices during operation.

[0078] This invention is not limited to the specific embodiments described above. The invention extends to any new feature or combination disclosed in this specification, as well as any new method or process step or combination disclosed herein.

Claims

1. A medical mixing device, characterized in that, include: The system includes a liquid container (401) for holding the liquid to be mixed, a support part (10), and a liquid container motion drive device; the support part (10) carries at least one of the liquid containers (401); the liquid container motion drive device is used to drive the liquid container (401) to perform a rotational motion to achieve liquid mixing under rotational motion; it also includes a support part drive device for driving the support part (10) to drive the liquid container (401) to perform a first motion in a manner different from the rotational motion; it also includes a motor (11), which is fixedly connected to the support part (10), and the motor (11) includes an output shaft (201), the two ends of which are respectively connected to the support part drive device. The device and liquid container drive device realize the power source of the first motion and rotational motion simultaneously by using the motor (11); one end of the output shaft (201) is connected to the container motion drive device, and the other end is connected to the center of the wheel (202). One end of the connecting rod (203) is eccentrically connected to the non-center part of the wheel (202), and the other end is connected to the fixed base. Under the action of the eccentrically set connecting rod (203), the motor (11) can drive the entire bearing part (10) to swing around the vertical center position with a certain amplitude. At the same time, the motor (11) can act on the liquid container motion drive device to drive the liquid container (401) to rotate around its axis, so as to realize the liquid mixing under the compound motion.

2. The medical mixing device as described in claim 1, characterized in that, The liquid container motion drive device includes at least two stages of speed enhancement mechanism, rotating shaft (301) and transmission shaft (302). The end of the rotating shaft (301) is connected to a transmission gear (301a), which meshes with the transmission gear (302a) and can transmit the rotational motion of the output shaft (201) of the motor (11) to the transmission shaft (302). The speed enhancement mechanism adopts a transmission structure with a high number of teeth meshing with a low number of teeth.

3. The medical mixing device as described in claim 2, characterized in that, The two-stage speed enhancement mechanism includes a first-stage speed enhancement mechanism and a second-stage speed enhancement mechanism; the first-stage speed enhancement mechanism includes a first meshing gear (302b), which meshes with a second meshing gear (303a) disposed on the intermediate shaft (303); the second-stage speed enhancement mechanism is located on the intermediate shaft (303) and includes a third meshing gear (303b), which meshes with a fourth meshing gear (304a) disposed at the bottom of the bearing part (10).

4. The medical mixing device as described in claim 3, characterized in that, The gear ratio of the primary speed-boosting mechanism and the secondary speed-boosting mechanism is 3:1 to 10:

1.

5. The medical mixing device as described in claim 1, characterized in that, The first motion is a periodic oscillating motion with a trajectory of a cycloid.

6. The medical mixing device as described in claim 1, characterized in that, The carrier (10) includes a plurality of carrier ports (101), such that each carrier port (101) can receive a corresponding liquid container (401).

7. A system based on the mixing device of claim 1, characterized in that, It includes at least one of the mixing devices as described in claim 1.

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