Method, system, electronic device and storage medium for determining eye tissue information

Abstract

Embodiments of the present invention disclose a method, system, electronic device, and storage medium for determining ocular tissue information. The method comprises: injecting prepared magnetic nanoparticles into the eye region and adjusting the eye region to the light beam exit position of a data acquisition system; the eye region includes the cornea, sclera, lens, ciliary muscle, and / or retina; applying a controllable voltage to an electromagnetic coil in an excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles in the eye region; and transmitting a laser beam based on a laser in the data acquisition system so that the laser beam enters the eye region from the light beam exit position, and receiving a reflected light beam fed back from the eye region to obtain target ocular tissue data; and analyzing and processing the target ocular tissue data to obtain mechanical characteristic parameters corresponding to the eye region. The present invention can improve the comfort of the subject being measured during the measurement process.

Description

Technical Field

[0001] Embodiments of the present invention relate to the technical field of elastic imaging, and in particular to a method, system, electronic device, and storage medium for determining eye tissue information. Background Art

[0002] Eye diseases can seriously affect people's normal life and work. Clinical detection of the biomechanical properties of eye tissues is of great significance for early diagnosis, progression tracking and efficacy evaluation of diseases.

[0003] Prior art often uses piezoelectric transducers and acoustic actuators to directly contact the ocular tissue of the subject being tested, driving the tissue to generate mechanical waves. The ocular tissue data reflected by these mechanical waves is analyzed to determine the biomechanical properties of the tissue being tested. However, due to the direct contact nature of these transducers and acoustic actuators, local anesthesia is required during biomechanical testing of ocular tissue, causing discomfort to the subject. Summary of the Invention

[0004] Embodiments of the present invention provide a method, system, electronic device, and storage medium for determining eye tissue information, so as to improve the comfort of an object to be detected during the detection process and accurately determine the eye tissue information.

[0005] In a first aspect, an embodiment of the present invention provides a method for determining eye tissue information, comprising:

[0006] Injecting the prepared magnetic nanoparticles into the eye, and adjusting the eye to the light beam exit position of the data acquisition system; wherein the eye includes the cornea, sclera, lens, ciliary muscle and / or retina;

[0007] Applying a controllable voltage to an electromagnetic coil in an excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles to move in the eye part; and

[0008] Sending a laser beam based on the laser in the data acquisition system so that the laser beam enters the eye part from the beam exit position, and receiving a reflected light beam fed back from the eye part to obtain target eye tissue data;

[0009] By analyzing and processing the target eye tissue data, mechanical characteristic parameters corresponding to the eye part are obtained.

[0010] In a second aspect, an embodiment of the present invention further provides a system for executing a method for determining ocular tissue information, the system comprising: a data acquisition system, and an excitation system used in conjunction with the data acquisition system;

[0011] The data acquisition system is in communication with the excitation system and is configured to control the laser beam emitted by the laser source to enter the eye portion from the beam exit position when receiving the synchronization signal sent by the excitation system;

[0012] The excitation system is arranged at the light beam exit position and is horizontal to the eye part in the first direction, and is used to drive the magnetic nanoparticles in the eye part to vibrate when the excitation system is in operation, so that the data acquisition system can obtain the target eye tissue data of the eye part under the action of the excitation system;

[0013] The data processing system communicates with the data acquisition system, and is used to obtain the target eye tissue data collected by the data acquisition system, and determine the mechanical characteristic parameters of the eye part according to the target eye tissue data.

[0014] In a third aspect, an embodiment of the present invention further provides an electronic device, the electronic device comprising:

[0015] one or more processors;

[0016] a storage device for storing one or more programs,

[0017] When the one or more programs are executed by the one or more processors, the one or more processors implement the method for determining eye tissue information provided by any embodiment of the present invention.

[0018] In a fourth aspect, an embodiment of the present invention further provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the method for determining eye tissue information provided by any embodiment of the present invention.

[0019] A method for determining ocular tissue information provided by an embodiment of the present invention involves injecting prepared magnetic nanoparticles into the eye. An electromagnetic coil in an excitation system generates a controllable magnetic field that drives the magnetic nanoparticles in the eye, thereby causing the ocular tissue to vibrate. This solves the problem of prior art techniques requiring direct contact with the eye tissue to induce ocular vibration. By controlling the magnetic nanoparticles to excite them with a controllable magnetic force, the present embodiment determines ocular tissue information without the need for local anesthesia for the subject to be tested, thereby improving the comfort and safety of the subject during the test. Furthermore, a laser in a data acquisition system transmits a laser beam so that the laser beam enters the eye from a beam exit position and receives a reflected beam fed back from the eye. By analyzing the information in the feedback beam, target ocular tissue data is obtained, thereby obtaining mechanical property parameters corresponding to the eye region, thereby accurately determining the mechanical properties of the target ocular tissue.

[0020] In addition, the system, electronic device and storage medium for determining eye tissue information provided by the present invention correspond to the above method and have the same beneficial effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention, the following is a brief introduction to the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0022] Figure 1 This is a flow chart of the method for determining eye tissue information provided in the first embodiment of the present invention;

[0023] Figure 2 A displacement curve diagram provided in Example 1 of the present invention;

[0024] Figure 3 This is a structural diagram of a system for determining eye tissue information provided in Example 2 of the present invention;

[0025] Figure 4 This is a structural diagram of a system for determining eye tissue information based on OCT provided in Example 2 of the present invention;

[0026] Figure 5 This is a structural diagram of another system for determining eye tissue information based on OCT provided in Example 2 of the present invention;

[0027] Figure 6 This is a schematic diagram of the processing flow provided by the third embodiment of the present invention;

[0028] Figure 7 A schematic diagram of signal waveforms provided in the third embodiment of the present invention;

[0029] Figure 8 This is a structural diagram of an electronic device provided in Example 4 of the present invention. DETAILED DESCRIPTION

[0030] The present invention will be further described in detail below with reference to the accompanying drawings and examples. It will be understood that the specific embodiments described herein are intended only to illustrate the present invention and are not intended to limit the present invention. It should also be noted that, for ease of description, the accompanying drawings only illustrate portions relevant to the present invention, not all structures.

[0031] It should be noted that before discussing exemplary embodiments in more detail, some exemplary embodiments are described as processes or methods depicted as flow charts. Although the flow charts describe the various operations (or steps) as sequential processes, many of the operations therein can be implemented in parallel, concurrently, or simultaneously. In addition, the order of the various operations can be rearranged. The process can be terminated when its operation is completed, but can also have additional steps not included in the accompanying drawings. The process can correspond to a method, function, procedure, subroutine, subprogram, etc.

[0032] In order to enable those skilled in the art to better understand the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0033] Example 1

[0034] Figure 1 This is a flowchart of a method for determining ocular tissue information provided in Embodiment 1 of the present invention. This method can be performed by a system for determining ocular tissue information, which can be implemented using software and / or hardware. The hardware can be an electronic device capable of implementing the method for determining ocular tissue information in Embodiment 1 of the present invention.

[0035] like Figure 1 As shown, the method of this embodiment may specifically include:

[0036] S101. Inject the prepared magnetic nanoparticles into the eye area, and adjust the eye area to the light beam emission position of the data acquisition system.

[0037] In a specific implementation, a magnetic nanoparticle solution containing magnetic nanoparticles can be prepared in advance and injected into the eye. The process of preparing and injecting the magnetic nanoparticle solution includes: mixing the magnetic nanoparticle solution to be treated with buffered saline and centrifuging to obtain the magnetic nanoparticle solution; and injecting or dripping the magnetic nanoparticle solution into the cornea, sclera, lens, ciliary muscle, and / or retina of the eye. When it is detected that the diffusion time of the magnetic nanoparticle solution in the eye reaches a preset time threshold, the excitation system and the data acquisition system are controlled to be in an active state, so that the data acquisition system collects target ocular tissue data when the excitation system acts on the eye.

[0038] The eye parts include the cornea, sclera, lens, ciliary muscle and / or retina, and the diameter of the magnetic nanoparticles is nanometer-scale or micrometer-scale. It should be noted that for exposed surface eye tissues such as the cornea and sclera, the magnetic nanoparticles can be applied in the form of eye drops, that is, only a few drops of magnetic nanoparticle solution are added to the eye tissue to make the magnetic nanoparticles adhere to the surface tissues of the cornea or sclera; for internal structural tissues such as the lens, retina, ciliary muscle and trabecular meshwork, one method is to inject the magnetic nanoparticle solution into the internal structural tissue through a syringe; another method is for the subject to be tested to swallow and ingest the magnetic nanoparticles, and use an additional magnetic field to assist in guiding them to the area to be tested in the eye tissue; for example, the magnetic nanoparticles can be iron oxide magnetic particles, which can be naturally degraded into oxygen and iron in the body and physiologically cleared from the systemic circulation by macrophages. In order to improve the comfort of the subject to be tested when determining tissue information, the diameter of the magnetic nanoparticles used can be nanometer-level; but for the method of surface dripping and post-test rinsing, it is also possible to use magnetic nanoparticles with a diameter of micrometer level for surface dripping to determine the eye tissue information, while ensuring the safety of the subject to be tested.

[0039] The excitation system is used to generate a controllable magnetic field. The excitation system may include an electromagnetic coil and a power supply. The power supply applies a controllable voltage to the electromagnetic coil in the excitation system, causing the electromagnetic coil to generate a controllable magnetic field under the action of the controllable voltage. The power supply may include an AC power supply and / or a DC power supply. The excitation system may also include devices such as resistors and filters. The voltage output by the power supply is regulated by the resistors and filters to provide a controllable voltage to the electromagnetic coil. The data acquisition system may be an optical imaging system that transmits a light beam to the eye and collects the reflected light beam. The biomechanical properties of the tissue in the eye are analyzed based on the reflected and transmitted light beams.

[0040] In a specific implementation, to ensure that the biomechanical information reflected by the eye tissue after the magnetic nanoparticles attached to the eye are captured by the data acquisition system after being stimulated, the eye can be aligned with the light beam output position of the data acquisition system. For example, when the data acquisition system is an OCT (optical coherence tomography) system, the eye can be aligned with the lens of the data acquisition system so that the eye is within the effective working range of the emitted light.

[0041] Furthermore, it is necessary to ensure that the position of the eye is within the action area of ​​the excitation system. If the eye is adjusted to the effective working range of the emitted light of the data acquisition system, the action area of ​​the excitation system cannot cover the position of the eye, then the position of the excitation system needs to be adjusted to ensure that the magnetic nanoparticles in the eye can be excited by the controllable magnetic field applied by the excitation system.

[0042] S102 . Apply a controllable voltage to the electromagnetic coil in the excitation system, so that the electromagnetic coil generates a controllable magnetic field that drives the magnetic nanoparticles to move in the eye based on the controllable voltage.

[0043] In particular, a controllable voltage can be applied to the electromagnetic coil in the excitation system through a power supply device, so that the electromagnetic coil generates a controllable magnetic field under the action of the controllable voltage. The magnetic nanoparticles attached to the ocular tissue vibrate under the action of the controllable magnetic field of the electromagnetic coil. The vibration also generates a certain force on the ocular tissue. The tissue responds to the forced vibration and generates shear waves that propagate within the tissue. It should be noted that the power supply device can generate different types of controllable voltages, such as DC voltage or AC voltage, and control the voltage amplitude, frequency, or phase and duration of the output controllable voltage. By inputting different controllable voltages to the electromagnetic coil, a variety of excitation modes can be generated, so that the controllable magnetic fields generated by the electromagnetic coil are different, so that the magnetic particles can drive the tissue to produce different vibration modes.

[0044] In this embodiment, a controllable voltage is applied to the electromagnetic coil in the excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles to move in the eye area. The implementation method can be: a voltage signal is generated based on a signal generator, and the voltage signal is amplified by a power amplifier to obtain a voltage amplification signal acting on the electromagnetic coil; the voltage amplification signal is applied to the electromagnetic coil so that the electromagnetic coil generates a controllable magnetic field; and the magnetic nanoparticles in the eye area are caused to move based on the controllable magnetic field.

[0045] In this embodiment, the excitation system also includes a signal generator and a power amplifier. The signal generator is used to generate a corresponding target voltage signal according to the settings; for example, the target voltage signal is a sine wave, square wave, triangle wave, sawtooth wave, or other signal. Those skilled in the art can set it according to the actual application, and this embodiment of the present invention is not limited to this. Furthermore, the excitation system also includes a power amplifier for amplifying the voltage signal generated by the signal generator, thereby providing a voltage capable of driving the electronic coil to generate a controllable magnetic field.

[0046] Optionally, before applying a controllable voltage to the electromagnetic coil in the excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles to move in the eye area, it also includes: adjusting the data acquisition system to a first acquisition mode to determine the area of ​​interest in the eye area based on the first acquisition mode; and acquiring target eye data of the area of ​​interest.

[0047] Specifically, the data acquisition system is a system capable of tracking particle vibration amplitudes within the micrometer and / or nanometer range, and includes at least one of an optical coherence tomography system, a magnetic resonance imaging system, and a B-ultrasound system. The data acquisition system may include a first acquisition mode and a second acquisition mode. The first acquisition mode may be used to acquire image information at various locations within the eye, thereby determining a region of interest based on the image information; the second acquisition mode may be used to acquire a reflected light beam generated after an emitted light beam enters the eye tissue, thereby determining the vibration of the eye tissue.

[0048] To more clearly illustrate the process of determining ocular tissue information using a data acquisition system, an optical coherence tomography system is used as an example. When the data acquisition system is an optical coherence tomography system, the first acquisition mode can be the optical coherence tomography system's B-mode imaging mode, which uses dynamic, real-time images to obtain a signal state reflecting the cross-sectional structure of the target ocular tissue. A region of interest (ROI) is determined based on the signal state, and one or more points of interest within the ROI can be identified as data acquisition points for the ocular tissue. The second acquisition mode includes an M-mode imaging mode, which repeatedly acquires target ocular tissue data at a predetermined frequency at selected data acquisition points.

[0049] The following briefly lists the commonly used excitation modes for optical coherence tomography system acquisition:

[0050] 1) Harmonic Excitation: Apply a sinusoidal magnetic force to induce harmonic oscillations in the ocular tissue. Combined with M-mode acquisition, modulate the repetition frequency or set a fixed repetition interval.

[0051] 2) Spectral excitation: A chirp signal with a frequency sweep across a certain range is used in conjunction with M-mode acquisition. Furthermore, by varying the electromagnetic coil input signal, excitation modes with varying amplitudes, spectra, and waveforms can be customized on demand.

[0052] S103. Send a laser beam based on the laser in the data acquisition system so that the laser beam enters the eye from the beam exit position, and receive the reflected light beam fed back from the eye to obtain the target eye tissue data.

[0053] It should be noted that the optical coherence tomography system proposed in the embodiments of the present invention is a commonly used imaging system in the prior art. The internal structure and operating principle of the optical coherence tomography system will not be described in detail here. Various optical imaging systems generated by adjusting the structure of the optical coherence tomography system based on conventional components are all within the scope of protection of the embodiments of the present invention.

[0054] In this embodiment, after the acquisition point is determined, it also includes: when a controllable voltage is applied to the electromagnetic coil in the excitation system, a data acquisition trigger signal is sent to the data acquisition system, so that the data acquisition system acquires the target eye tissue data of the eye part in the second acquisition mode based on the received data acquisition trigger signal.

[0055] Specifically, when the excitation system excites the electromagnetic coil to generate a controllable magnetic field, it can notify the data acquisition system to begin collecting vibrations of the ocular tissue by sending a data acquisition trigger signal to the data acquisition system. Upon receiving the data acquisition trigger signal, the data acquisition system can control the laser within the data acquisition system to emit a laser beam, causing the laser beam to be incident on a collection point in the ocular tissue. For each collection point, the collection point can be aligned with the position where the data acquisition system's beam enters the ocular tissue, thereby collecting target ocular data at that collection point in the ocular tissue. For multiple collection points, multiple sets of target ocular data can be determined accordingly.

[0056] Furthermore, after receiving the data acquisition trigger signal, the data acquisition system can confirm whether the current working mode is the second acquisition mode. If not, the current working mode is adjusted to the second acquisition mode to collect the reflected light beam and obtain the target eye tissue data based on the reflected light beam.

[0057] S104: Analyze and process the target eye tissue data to obtain mechanical characteristic parameters corresponding to the eye area.

[0058] In a specific implementation, the mechanical property parameters may reflect the mechanical properties of the eye, and may include at least one of an elastic modulus, a viscosity coefficient, and a relaxation time constant. After acquiring the target eye tissue data, the target eye tissue data may be analyzed and processed to obtain the mechanical property parameters of the eye, and the mechanical properties of the eye may be determined based on the mechanical property parameters.

[0059] In a specific implementation, the mechanical characteristic parameters of the eye part are determined by analyzing and processing the target eye tissue data as follows: obtaining the original spectral data in the target eye tissue data, and performing spectral correction and removing DC terms on the original spectral data to obtain a to-be-used interference signal with wave number as the independent variable; Fourier transforming the to-be-used interference signal to obtain multiple complex-valued signals of the original spectral data; determining the phase difference corresponding to the set depth information of each laser line by processing two adjacent complex-valued signals; for each phase difference, determining the current displacement corresponding to the current phase difference according to the time information corresponding to the current phase difference, the parameters of the eye tissue, and the beam wavelength of the laser beam; determining the relaxation time constant based on each current displacement, so as to determine the mechanical characteristic parameters of the eye part based on the relaxation time constant.

[0060] The target ocular tissue data includes raw spectral data, which is interference spectrum intensity data, namely, an A-line data sequence. Wavelength correction and DC term removal are performed on the raw spectral data, and the resulting data is converted into an interference signal to be used, with wave number as the independent variable, namely, an A-line data sequence to be used, with wave number as the independent variable. The laser lines can be individual A-lines in the A-line data sequence to be used, with wave number as the independent variable.

[0061] It should be noted that the phase signal distributed in the cornea is stable and does not change in a short period of time under a resting state. When the corneal tissue is stimulated, that is, when the magnetic nanoparticles attached to the corneal tissue vibrate, the corneal tissue is forced to produce a small deformation; the deformation causes an axial displacement between two adjacent samples in the corneal area, thereby causing the phase information of the target eye tissue data collected by the OCT system to change. Different depth information can be set for different regions of interest of the selected eye tissue; by obtaining the spectral data at the set depth information of the eye tissue, the phase difference corresponding to each laser line at the set depth information can be determined. The mechanical properties of the eye tissue can be reflected by determining the phase difference information corresponding to the two sampling processes of the target eye tissue data.

[0062] In order to more clearly illustrate the process of determining the mechanical characteristic parameters, the relaxation time constant can be taken as an example to illustrate the process of determining the displacement of the eye.

[0063] Specifically, the interference signal is subjected to Fourier transform to obtain multiple complex-valued signals with depth z as a variable. The calculation formula of the complex-valued signal S(z) is:

[0064]

[0065] in, is the phase information with depth z as a variable, and A(z) is the amplitude with depth z as a variable.

[0066] In this implementation, the OCT phase signal is randomly distributed in the ocular tissue. The phase signal distributed in the cornea of ​​the tested object in the resting state is stable and does not change in a short period of time. However, once the corneal tissue is stimulated, when the magnetic nanoparticles vibrate along the vibration propagation direction, the ocular tissue is forced to produce a small deformation. The axial displacement between the two A scans obtained at the same lateral position will cause a phase change, and the phase change is directly related to the deformation of the ocular tissue. By performing a cross-correlation on two adjacent A lines, the phase information can be obtained. The formula is as follows:

[0067]

[0068] in, is the phase difference information with depth z as the variable, j is the jth A line, S j (z) is the complex value signal of the jth A line with depth z as the variable, S j (z) is the complex-valued signal of the j+1th A-line with depth z as the variable. Furthermore, based on the determined phase information, the phase difference information corresponding to each laser line can be determined. For each phase difference, the current displacement corresponding to the current phase difference is determined based on the time information corresponding to the current phase difference, the parameters of the eye tissue, and the wavelength of the laser beam. The displacement d is calculated as follows:

[0069]

[0070] in, is the phase difference information with depth z as a variable, λ0 is the wavelength of the laser beam in the OCT system, n is the refractive index of the laser source in the eye tissue; T1 and T2 are the scanning times corresponding to the two A scans.

[0071] In this embodiment, a displacement curve can be generated based on the determined displacement. Since ocular tissue responds differently to different stimuli, once the excitation signal is determined, characteristic parameters can be determined from the plotted displacement curve through analysis to characterize the mechanical properties of the ocular tissue.

[0072] For example, when the force acting on the eye tissue cannot be determined, the system output based on the Voigt model can estimate the time constant, and then the biomechanical properties of the tissue can be described in a parametric way. The elasticity and viscosity related to the magnitude of the acoustic radiation force can also be determined from the displacement response, which is called relative elasticity. The corresponding relative viscosity is calculated through the relative elasticity, and the mechanical properties are expressed through viscoelastic response. The VisR (Viscoelastic Response) imaging method can also be used, that is, the biomechanical properties of the tissue are evaluated by calculating the relaxation time constant, which comes from the displacement waveform of the response. The displacement is obtained at the same point using excitation, which has a higher spatial resolution. The principle of the VisR method is as follows. The Voigt model with a linear spring with an elastic modulus of μ and a damper with a viscosity coefficient of η in parallel is used to describe the mechanical properties of soft tissue, and the relationship between force and displacement during the relaxation process is described by a differential equation, as shown below:

[0073]

[0074] Among them, E μ is the relaxation elastic modulus, τ is the relaxation time constant at constant stress, F(t) is the force generated over time, in Newtons, x(t) is the axial displacement generated over time, and t is time. The relationship between the relaxation elastic modulus and relaxation time constant and the viscoelastic parameters is as follows:

[0075]

[0076] That is, the relaxation elastic modulus is numerically equal to the elastic modulus μ of the Voigt model, and the relaxation time constant τ is equal to the ratio of the elastic modulus μ to the viscosity coefficient η in the Voigt model.

[0077] In this embodiment, a relaxation time constant is determined based on each current displacement, and the mechanical characteristic parameters of the eye part are determined based on the relaxation time constant, including: determining at least one to-be-processed moment based on the duration of a single excitation corresponding to the excitation system; obtaining the current displacement corresponding to at least one to-be-processed moment, and determining the relaxation time constant based on the at least one current displacement.

[0078] In a specific implementation, a displacement curve can be generated based on the determined displacement. The peak moment corresponding to the peak in the displacement curve can be determined as the pending displacement moment, and the relaxation time constant can be determined based on the current displacement corresponding to the peak moment. Furthermore, after determining multiple pending displacement moments, the relaxation time constant can be determined based on the current displacement corresponding to each pending displacement moment.

[0079] In order to better illustrate the process of determining the relaxation time constant, three processing moments can be determined as an example. Figure 2 A displacement curve diagram provided in the first embodiment of the present invention is shown in FIG. Figure 2 As shown, the magnetic force acting on the tissue is described as force F AMF , the duration of one excitation is t AMF , three processing times t1, t2 and t3 can be selected respectively. t1 should be greater than t AMF According to the above Voigt differential equation model, the displacement D1 at time t1 is:

[0080]

[0081] Where D1 is the displacement generated at the time t1 to be treated, and the magnetic force acting on the tissue is described as force expressed as F AMF , the duration of one excitation is t AMF , E μ is the relaxation elastic modulus, τ is the relaxation time constant at constant stress, and e is the base of the natural logarithm.

[0082] The displacement of the eye tissue at time t2 is D2, and the duration of the displacement at time t2 is t AMF The second excitation. When t3 reaches the condition of t3 = t1 + t2, the displacement D3 is measured. The calculation formula of D3 is as follows:

[0083]

[0084] Where D3 is the displacement generated at the time t3 to be treated, and the magnetic force acting on the tissue is described as force expressed as F AMF , the duration of one excitation is t AMF , E μ is the relaxation elastic modulus, τ is the relaxation time constant at constant stress, and e is the base of the natural logarithm.

[0085] Therefore, τ can be estimated based on the displacements corresponding to the three processing moments. The relaxation time constant is then calculated as:

[0086]

[0087] Where η is the viscosity coefficient. After the first magnetic excitation, the displacement curve is obtained at time t1, and the corresponding displacement is D1. The time when the second force is applied is t2, and the corresponding displacement is D2. After the second force is applied, the time corresponding to the third displacement point is t3, and the corresponding displacement is D3. t3 = t1 + t2, and E is the relative viscosity.

[0088] This embodiment further includes determining an elasticity map representing the mechanical properties of the eye based on the mechanical property parameters corresponding to each region of interest and the ocular tissue image determined by the data acquisition system. Specifically, to clearly and intuitively understand the mechanical properties of the eye, an elasticity map representing the mechanical properties of the eye can be generated.

[0089] Specifically, the data acquisition system can capture ocular tissue images in imaging mode and generate an elastogram by combining the ocular tissue images with the determined mechanical property parameters of the region of interest. The elastogram can reflect the relaxation time constant and / or viscoelastic parameters of the region of interest. The elastogram can be a two-dimensional or three-dimensional graph, and the determined elastogram can be displayed on a display device for user viewing.

[0090] A method for determining ocular tissue information provided by an embodiment of the present invention involves injecting prepared magnetic nanoparticles into the eye. An electromagnetic coil in an excitation system generates a controllable magnetic field that drives the magnetic nanoparticles in the eye, thereby causing the ocular tissue to vibrate. This solves the problem of prior art techniques requiring direct contact with the eye tissue to induce ocular vibration. By controlling the magnetic nanoparticles to excite them with a controllable magnetic force, the present embodiment determines ocular tissue information without the need for local anesthesia for the subject to be tested, thereby improving the comfort and safety of the subject during the test. Furthermore, a laser in a data acquisition system transmits a laser beam so that the laser beam enters the eye from a beam exit position and receives a reflected beam fed back from the eye. By analyzing the information in the feedback beam, target ocular tissue data is obtained, thereby obtaining mechanical property parameters corresponding to the eye region, thereby accurately determining the mechanical properties of the target ocular tissue.

[0091] Example 2

[0092] Figure 3 This is a structural diagram of a system for determining eye tissue information provided by Embodiment 2 of the present invention. The system for determining eye tissue information can be used to execute the above method. Figure 3 As shown, the system includes: a data acquisition system 10, and an excitation system 11 used in conjunction with the data acquisition system 10;

[0093] The data acquisition system 10 is in communication with the excitation system 11 and is configured to control the laser beam emitted by the laser source to enter the eye portion from the beam exit position when receiving the synchronization signal sent by the excitation system 11;

[0094] an excitation system 11, disposed at the light beam exit position and parallel to the eye portion in a first direction, for driving the magnetic nanoparticles in the eye portion to vibrate when the excitation system 11 is in operation, so that the data acquisition system acquires target ocular tissue data of the eye portion under the action of the excitation system;

[0095] The data processing system 12 communicates with the data acquisition system 10 and is used to obtain the target eye tissue data collected by the data acquisition system 10 and determine the mechanical characteristic parameters of the eye part according to the target eye tissue data.

[0096] In this embodiment, an injection solution containing magnetic nanoparticles can be prepared in advance, and the prepared magnetic nanoparticle solution can be injected into the eye area. The preparation and injection process includes: fusing the magnetic nanoparticle solution to be treated with buffered saline and centrifuging it to obtain a magnetic nanoparticle solution; injecting or dripping the magnetic nanoparticle solution into the corneal area, scleral area, lens, ciliary muscle and / or retina of the eye area; when it is detected that the diffusion time of the magnetic nanoparticle solution in the eye area reaches a preset time threshold, controlling the excitation system and the data acquisition system to be in working state, so that the data acquisition system collects target eye tissue data when the excitation system acts on the eye area.

[0097] In a specific implementation, the excitation system 11 is used to generate a controllable magnetic field. The excitation system 11 may include an electromagnetic coil and a power supply. The power supply applies a controllable voltage to the electromagnetic coil in the excitation system, causing the electromagnetic coil to generate a controllable magnetic field under the action of the controllable voltage. The power supply may include an AC power supply and / or a DC power supply. The excitation system 11 may also include resistors, filters, and other devices to provide the controllable voltage to the electromagnetic coil. The data acquisition system may be an optical imaging system that transmits a light beam to the eye and collects the reflected light beam to obtain target ocular tissue data based on the reflected light beam.

[0098] When the data acquisition system 10 acquires target ocular tissue data, it can send the target ocular tissue data to the data processing system 12. The data processing system 12 analyzes and processes the target ocular tissue data to obtain mechanical property parameters corresponding to the ocular region. The data processing system 12 may include a computer control terminal, which establishes a communication connection with the data acquisition system 10 via a wired connection and / or a wireless connection.

[0099] To accurately capture data from target ocular tissue, the data acquisition system must be capable of tracking particle vibration amplitudes within the micrometer and / or nanometer range. The diameter of the magnetic nanoparticles is in the nanometer or micrometer range. This data acquisition system includes both an OCT (optical coherence tomography) system and a medical ultrasound imaging system.

[0100] Figure 4This is a block diagram of a system for determining ocular tissue information based on OCT, provided in Example 2 of the present invention. The excitation system and OCT system operate in tandem via a synchronization signal. When the excitation system begins operating, it sends a synchronization signal to the data acquisition system. The OCT system includes a laser as a laser source. When the OCT system receives the synchronization signal, it controls the laser beam emitted by the laser source to enter the eye from the beam exit position, thereby acquiring a reflected beam after the laser beam enters the eye. This reflected beam can reflect the phase information of the ocular tissue.

[0101] In a specific implementation, a card slot can be provided on the outside of the data acquisition system, and the excitation system and the data acquisition system are physically connected in a detachable manner. The excitation system is positioned at the beam exit position and parallel to the eye in a first direction. The first direction includes the normal direction of the eye tissue, and the range of action of the excitation system must also include the position of the eye tissue. This detachable arrangement allows the excitation system to be loaded onto different data acquisition systems as an independent device for use, facilitating the replacement of excitation systems with different structures, thereby increasing the structural diversity and richness of the system for determining ocular tissue information.

[0102] Specifically, when the excitation system is working, the electromagnetic coil generates magnetic force to drive the magnetic nanoparticles in the eye to vibrate, and the data acquisition system obtains the target eye tissue data of the eye under the action of the excitation system through the feedback reflected light speed.

[0103] Figure 5 This is a structural diagram of another system for determining eye tissue information based on OCT provided in the second embodiment of the present invention. Figure 5 As shown, the system includes an OCT system, an excitation system consisting of a power supply and an electromagnetic coil, and a PC control terminal. Excitation and detection are performed through software control, and the propagation velocity of the shear wave is extracted from the spectrum information to estimate the mechanical properties of the cornea.

[0104] The OCT system includes a laser source, an isolator, a collimator, a fiber coupler, a reference arm, a sample arm, and a CCD camera. The laser source is specifically a broadband laser source. Laser light from the laser source passes through the isolator and is then split by a fiber coupler. Some sub-beams enter the reference arm, while others enter the sample arm. The sub-beams entering the sample arm are focused onto the surface of the ocular tissue by a scanning galvanometer and a focusing lens. The focusing lens can, for example, be a lens.

[0105] Specifically, an electromagnetic coil is placed between the eye tissue and the OCT lens. The electromagnetic coil is integrated with the OCT system so that the coil is aligned with the OCT lens, and the near-infrared light beam can reach the eye tissue through the electromagnetic coil. The reference arm is composed of a static mirror, including two lenses and a reflector. The sub-beam first passes through the two lenses and is incident on the reflector to obtain a reflected light beam. The sample arm includes two lenses and two scanning galvanometers. The incident sub-beam passes through the lens and is incident on the scanning galvanometer, and is refracted and then incident on another scanning galvanometer, and is refracted again to ensure that the incident direction of the refracted sub-beam after passing through the lens is aligned with the electromagnetic coil, and reaches the eye tissue to be measured through the electromagnetic coil. The embodiment of the present invention can control the incident angle of the sub-beam and the incident position on the eye tissue by adjusting the placement of the scanning galvanometer and the lens.

[0106] Furthermore, in order to ensure working stability, the electromagnetic coil can be cooled by encapsulating it in a hollow cylindrical plastic container and using water circulation cooling in the space of the container.

[0107] like Figure 5 As shown, the excitation system includes: a signal generator, a power amplifier and an electromagnetic coil; wherein the signal generator is connected to the power amplifier and is used to apply an initial voltage signal; the power amplifier is used to amplify the initial voltage signal to obtain a target voltage signal so that the target voltage signal acts on the electromagnetic coil; the electromagnetic coil is used to convert the target voltage signal into magnetic field information.

[0108] In a specific implementation, the signal generator can generate an initial voltage signal with a corresponding waveform and amplitude according to the settings. For example, the waveform of the initial voltage signal can be a sine wave, square wave, triangle wave, sawtooth wave, etc., and the amplitude can be a voltage signal of ±5V. Furthermore, to better excite the electromagnetic coil, the initial voltage signal can be amplified by a power amplifier to provide a target voltage signal capable of driving the electronic coil to generate a controllable magnetic field.

[0109] The system disclosed in an embodiment of the present invention for performing a method for determining ocular tissue information includes: a data acquisition system and an excitation system used in conjunction with the data acquisition system; the data acquisition system controls a laser beam emitted by a laser source to enter the eye from a beam exit position upon receiving a synchronization signal sent by the excitation system; the excitation system drives magnetic nanoparticles in the eye to vibrate when the excitation system is in operation, so that the data acquisition system obtains target ocular tissue data of the eye under the action of the excitation system; the data processing system obtains the target ocular tissue data collected by the data acquisition system, and determines mechanical characteristic parameters of the eye based on the target ocular tissue data. In this embodiment of the present invention, the excitation system generates a controllable magnetic force to excite the magnetic nanoparticles to vibrate, and the data acquisition system collects the target ocular tissue data generated by the vibration of the magnetic nanoparticles. The target ocular tissue data is analyzed to obtain mechanical characteristic parameters reflecting the elasticity of the ocular tissue, thereby avoiding direct contact with the cornea and improving the comfort of the subject to be measured during the measurement process.

[0110] Example 3

[0111] In order to more clearly illustrate the technical solution of the exemplary embodiment of the present invention, the workflow of the solution of the present invention is described. Figure 6 This is a schematic diagram of the processing flow provided by the third embodiment of the present invention. The workflow specifically includes the following steps:

[0112] (1) Sample preparation: The concentration can be prepared in a centrifuge tube and then dispersed by a vortex mixer until the magnetic nanoparticle solution is mixed in phosphate buffered saline (PBS) to complete the preparation of the magnetic nanoparticle solution. The magnetic nanoparticles (MNPs) can be ferroferric oxide particles. After mixing, a syringe can be used to draw the required amount of magnetic nanoparticle solution from the center of the entire solution volume, and the magnetic nanoparticle drops can be dripped into the eye area of ​​the subject. When the magnetic nanoparticle dripping is completed, the minimum aggregation of the magnetic nanoparticles is observed. The preset time threshold can be two hours, and wait for two hours to allow the magnetic particles to diffuse into the eye tissue; to ensure that the magnetic particles can diffuse in the eye tissue, a permanent magnet can be placed above the eye tissue.

[0113] (2) The subject sits quietly with their eyes open, keeping the eye tissue flush with the coil opening of the electromagnetic coil. When the signal generator in the excitation system starts working, it sends a synchronization signal to the OCT system, which then emits the laser line through the OCT system, allowing the emitted light to pass through the lens and directly hit the eye tissue. In the B-mode real-time imaging mode, the optimal signal state of the biological soft tissue to be measured is selected through dynamic real-time images, and the region of interest is selected. The sampling point is determined in the region of interest.

[0114] (3) Determine whether the object to be measured is in a stable state. If so, control the PC control terminal to switch to M-mode imaging mode for data acquisition. Exemplarily, the acquisition time in this mode can last for 2 seconds. After the data acquisition is completed, the object to be measured can choose to continue to acquire data again. The data acquired after the acquisition can directly overwrite the data acquired previously, or the data acquired each time can be stored. This embodiment of the present invention is not limited to this.

[0115] Furthermore, the position can be readjusted by switching to the B-mode real-time imaging mode, and the points of interest of the eye tissue of the object to be measured can be determined again. Data can be collected again and transmitted to the PC control terminal, and the collected data can be processed by the PC terminal to obtain phase difference information.

[0116] Figure 7 Schematic diagram of signal waveform provided by the third embodiment of the present invention; Figure 7 As shown in the figure, the "Data Acquisition Timing" shows two waveforms, where the horizontal line is used to represent the change in the level signal that drives the galvanometer to deflect, and each change in the level represents movement to the next data acquisition point; and each vertical line represents the repeated acquisition of Line A.

[0117] During M-mode scanning, the entire process involves connecting the PC control terminal to the excitation system, receiving a synchronization signal from the excitation system, and then sending a trigger signal to the OCT system to activate the system. The signal generator in the excitation system generates a sinusoidal signal that drives the electromagnetic coil. This signal, which is then driven by a power amplifier, generates a controllable magnetic field. M-mode scanning involves acquiring M-mode data using B-mode at different spatial locations.

[0118] For example, the controllable magnetic force generated by the electromagnetic coil based on the sinusoidal signal can be set to The formula is described as:

[0119]

[0120] Among them, μ0 is the magnetic permeability, which is a constant; V MNP is the alternating voltage, Δx is the difference between the magnetic susceptibility of the magnetic nanoparticles and the cutoff magnetic susceptibility, is the magnetic field, The formula shows that there are two key requirements for generating a sufficiently strong magnetic force: (1) a significant magnetic field gradient and (2) a large difference between the magnetic susceptibility of the magnetic nanoparticles and that of the surrounding medium.

[0121] In practical applications, a magnetic field gradient can be generated by placing an external electromagnetic coil near the ocular tissue. To generate a sinusoidal oscillating magnetic force and thus induce magnetomotion, an AC voltage with a square root of a sinusoidal pattern can be used to power the electromagnetic coil to generate a sinusoidal signal that is applied to the excitation system. For example, the relationship between the controllable magnetic force, magnetic flux, and AC voltage can be:

[0122]

[0123] Among them, the controllable magnetic force can be set to is the magnetic flux, and V is the alternating voltage that drives the electromagnetic coil.

[0124] Furthermore, when the signal generator in the excitation system sends out a sinusoidal signal to drive the electromagnetic coil, the scanning galvanometer starts to work and sends out a Figure 7 The galvanometer waveform signal shown here enables simultaneous data acquisition by the CCD camera, activation of the electromagnetic coil, and scanning current detection. By performing multiple M-mode imaging measurements at different radial positions in the region of interest, multiple A-lines measured as a function of time are obtained, thereby acquiring target ocular tissue data. At the beginning of each data acquisition, the electromagnetic coil is activated to generate a square root sine waveform of a given frequency.

[0125] (4) After the data is collected, the spectral data file can be exported by the open phase-sensitive OCT platform. Windowing and DC removal operations are performed through MATLAB, and complex OCT data is obtained after Fourier transformation. The phase of the complex OCT data is obtained and phase unwrapping is performed to adjust the phase data distortion caused by phase wrapping. Subsequently, the phase difference is extracted, the displacement of the tissue is calculated, and Fourier transformation is performed on it. The tissue displacement data at a certain frequency can be obtained and the mechanical characteristic parameters can be extracted. Furthermore, to facilitate viewing and analyzing the data, a phase shift curve can be drawn using the phase shift data. By introducing a mathematical model, the relationship between the viscosity and elasticity of the eye tissue is quantified and the tissue mechanical properties of the eye tissue are estimated.

[0126] The embodiments of the present invention determine information about ocular tissue by controlling magnetic force to excite magnetic nanoparticles, thus avoiding direct contact with the cornea and improving the comfort of the subject to be measured during the measurement process. Furthermore, the OCT system is combined with an electromagnetic coil, which has the characteristics of faster imaging and shorter measurement time, thus reducing patient discomfort. The electromagnetic coil is inexpensive and has a simple structure, and can be directly installed on the optical coherence imaging device, improving its ease of use.

[0127] Example 4

[0128] Figure 8 This is a structural diagram of an electronic device provided in Example 4 of the present invention. Figure 8FIG2 is a block diagram of an exemplary electronic device 20 suitable for implementing an embodiment of the present invention. The electronic device 20 shown is only an example and should not limit the functionality and scope of use of the embodiments of the present invention.

[0129] like Figure 8 As shown, electronic device 20 is a general-purpose computing device. Components of electronic device 20 may include, but are not limited to, one or more processors or processing units 201, system memory 202, and a bus 203 connecting various system components (including system memory 202 and processing unit 201).

[0130] Bus 203 represents one or more of several types of bus structures, including a memory bus or memory controller, a peripheral bus, an accelerated graphics port, a processor, or a local bus using any of a variety of bus architectures. Examples of these architectures include, but are not limited to, an Industry Standard Architecture (ISA) bus, a Micro Channel Architecture (MAC) bus, an Enhanced ISA bus, a Video Electronics Standards Association (VESA) local bus, and a Peripheral Component Interconnect (PCI) bus.

[0131] The electronic device 20 typically includes a variety of computer system readable media. These media can be any available media that can be accessed by the electronic device 20, including volatile and non-volatile media, removable and non-removable media.

[0132] The system memory 202 may include computer system readable media in the form of volatile memory, such as random access memory (RAM) 204 and / or cache memory 205. The electronic device 20 may further include other removable / non-removable, volatile / non-volatile computer system storage media. By way of example only, the storage system 206 may be used to read and write to non-removable, non-volatile magnetic media. A magnetic disk drive may be provided for reading and writing to a removable non-volatile magnetic disk (e.g., a "floppy disk"), as well as an optical disk drive for reading and writing to a removable non-volatile optical disk (e.g., a CD-ROM, DVD-ROM, or other optical media). In these cases, each drive may be connected to the bus 203 via one or more data media interfaces. The memory 202 may include at least one program product having a set (e.g., at least one) of program modules configured to perform the functions of various embodiments of the present invention.

[0133] A program / utility 208 having a set (at least one) of program modules 207 may be stored, for example, in memory 202. Such program modules 207 include, but are not limited to, an operating system, one or more application programs, other program modules, and program data, each of which, or some combination thereof, may include an implementation of a network environment. Program modules 207 generally perform the functions and / or methods of the embodiments described herein.

[0134] The electronic device 20 may also communicate with one or more external devices 209 (e.g., a keyboard, a pointing device, a display 210, etc.), one or more devices that enable a user to interact with the electronic device 20, and / or any device that enables the electronic device 20 to communicate with one or more other computing devices (e.g., a network card, a modem, etc.). Such communication may occur via an input / output (I / O) interface 211. Furthermore, the electronic device 20 may also communicate with one or more networks (e.g., a local area network (LAN), a wide area network (WAN), and / or a public network, such as the Internet) via a network adapter 212. As shown, the network adapter 212 communicates with other modules of the electronic device 20 via a bus 203. It should be understood that other hardware and / or software modules may be used in conjunction with the electronic device 20, including but not limited to microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data backup storage systems.

[0135] The processing unit 201 executes various functional applications and data processing by running programs stored in the system memory 202 .

[0136] The electronic device provided by the present invention can implement the following method: injecting prepared magnetic nanoparticles into the eye and adjusting the eye to the light beam exit position of a data acquisition system; wherein the eye includes the cornea, sclera, lens, ciliary muscle, and / or retina; applying a controllable voltage to an electromagnetic coil in an excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles in the eye; and transmitting a laser beam based on a laser in the data acquisition system so that the laser beam enters the eye from the light beam exit position and receives a reflected light beam fed back from the eye to obtain target eye tissue data; and analyzing and processing the target eye tissue data to obtain mechanical property parameters corresponding to the eye. The embodiments of the present invention determine eye tissue information by controlling magnetic force to excite magnetic nanoparticles, avoiding direct contact with the cornea and improving the comfort of the subject to be measured during the measurement process.

[0137] Example 5

[0138] An embodiment of the present invention provides a storage medium containing computer-executable instructions. When the computer-executable instructions are executed by a computer processor, the computer-executable instructions are used to perform a method for determining ocular tissue information. The method includes:

[0139] Prepared magnetic nanoparticles are injected into the eye, and the eye is adjusted to the light beam exit position of the data acquisition system; the eye includes the cornea, sclera, lens, ciliary muscle, and / or retina; a controllable voltage is applied to the electromagnetic coil in the excitation system, so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles in the eye; and a laser beam is transmitted from the laser in the data acquisition system so that the laser beam enters the eye from the light beam exit position, and a reflected light beam fed back from the eye is received to obtain target eye tissue data; the target eye tissue data is analyzed and processed to obtain mechanical property parameters corresponding to the eye. In this embodiment of the present invention, by determining eye tissue information through controllable magnetic excitation of magnetic nanoparticles, direct contact with the cornea is avoided, thereby improving the comfort of the subject to be measured during the measurement process.

[0140] Of course, the storage medium containing computer-executable instructions provided in an embodiment of the present invention is not limited to the method operations described above, and can also execute related operations in the method for determining eye tissue information provided in any embodiment of the present invention.

[0141] The computer storage medium of the embodiment of the present invention can adopt any combination of one or more computer-readable media. Computer-readable media can be computer-readable signal media or computer-readable storage media. Computer-readable storage media can be, for example, but not limited to, electrical, magnetic, optical, electromagnetic, infrared, or semiconductor systems, devices or components, or any combination thereof. More specific examples (non-exhaustive list) of computer-readable storage media include: an electrical connection with one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination thereof. In this document, a computer-readable storage medium can be any tangible medium containing or storing a program that can be used by an instruction execution system, device or device or used in combination with it.

[0142] A computer-readable signal medium may include a data signal propagated in baseband or as part of a carrier wave, which carries computer-readable program code. Such propagated data signals may take various forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination thereof. A computer-readable signal medium may also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport a program for use by or in conjunction with an instruction execution system, apparatus, or device.

[0143] Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.

[0144] The computer program code for performing the operations of the embodiments of the present invention can be written in one or more programming languages ​​or a combination thereof, including object-oriented programming languages ​​such as Java, Smalltalk, C++, and conventional procedural programming languages ​​such as "C" or similar programming languages. The program code can be executed entirely on the user's computer, partially on the user's computer, as a separate software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In cases involving a remote computer, the remote computer can be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (e.g., via the Internet using an Internet service provider).

[0145] Note that the above are only preferred embodiments of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and that various obvious changes, readjustments, and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments and may include many other equivalent embodiments without departing from the concept of the present invention. The scope of the present invention is determined by the scope of the appended claims.

Claims

1. A method for determining eye tissue information, characterized in that: include: Injecting the prepared magnetic nanoparticles into the eye, and adjusting the eye to the light beam exit position of the data acquisition system; wherein the eye includes the cornea, sclera, lens, ciliary muscle and / or retina; Adjusting the data acquisition system to a first acquisition mode to determine a region of interest in the eye based on the first acquisition mode; wherein the first acquisition mode is used to acquire image information of various positions of the eye, thereby determining the region of interest based on the image information; collecting target eye data of the region of interest; Applying a controllable voltage to the electromagnetic coil in the excitation system so that the electromagnetic coil generates a controllable magnetic field that drives the magnetic nanoparticles to move in the eye part based on the controllable voltage; when applying the controllable voltage to the electromagnetic coil in the excitation system, sending a data acquisition trigger signal to the data acquisition system so that the data acquisition system acquires target eye tissue data of the eye part in a second acquisition mode based on the received data acquisition trigger signal; wherein the second acquisition mode is used to acquire a reflected light beam generated after the emitted light beam is incident on the eye tissue to determine the vibration condition of the eye tissue; and Sending a laser beam based on the laser in the data acquisition system so that the laser beam enters the eye part from the beam exit position, and receiving a reflected light beam fed back from the eye part to obtain target eye tissue data; By analyzing and processing the target eye tissue data, mechanical characteristic parameters corresponding to the eye part are obtained.

2. The method according to claim 1, characterized in that The step of applying a controllable voltage to an electromagnetic coil in an excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles to move in the eye comprises: A signal generator generates a voltage signal, and a power amplifier amplifies the voltage signal to obtain a voltage amplification signal acting on the electromagnetic coil; Applying the voltage amplified signal to the electromagnetic coil to cause the electromagnetic coil to generate a controllable magnetic field; The controllable magnetic field acts on the magnetic nanoparticles in the eye region, causing movement in the eye region.

3. The method according to claim 1, characterized in that The data acquisition system includes at least one of an optical coherence tomography system, a magnetic resonance imaging system, and an ultrasound imaging system.

4. The method according to claim 1, wherein The step of analyzing and processing the target eye tissue data to obtain mechanical characteristic parameters corresponding to the eye part includes: Acquiring original spectral data from the target eye tissue data, and performing spectral correction and DC removal on the original spectral data to obtain an interference signal to be used with wave number as an independent variable; Performing Fourier transformation on the interference signal to be used to obtain a plurality of complex-valued signals of the original spectral data; By processing two adjacent complex-valued signals, the phase difference corresponding to the set depth information of each laser line is determined; For each phase difference, determining a current displacement corresponding to the current phase difference based on time information corresponding to the current phase difference, parameters of the eye tissue, and a wavelength of the laser beam; Based on each current displacement, a relaxation time constant is determined, so as to determine a mechanical characteristic parameter of the eye part based on the relaxation time constant.

5. The method according to claim 4, characterized in that The step of determining a relaxation time constant based on each current displacement, and determining a mechanical characteristic parameter of the eye portion based on the relaxation time constant, includes: Determining at least one to-be-processed moment based on a duration of a single stimulus corresponding to the stimulus system; A current displacement corresponding to the at least one time to be processed is acquired, and the relaxation time constant is determined according to the at least one current displacement.

6. The method according to claim 1, characterized in that Also includes: An elasticity map representing the mechanical properties of the eye is determined based on the mechanical property parameters corresponding to each region of interest and the eye tissue image determined by the data acquisition system.

7. A system for executing the method according to any one of claims 1 to 6, characterized in that: include: A data acquisition system, and an excitation system used in conjunction with the data acquisition system; The data acquisition system is in communication with the excitation system and is configured to control the laser beam emitted by the laser source to enter the eye portion from the beam exit position when receiving a synchronization signal sent by the excitation system; The excitation system is arranged at the light beam exit position and is horizontal to the eye part in the first direction, and is used to drive the magnetic nanoparticles in the eye part to vibrate when the excitation system is in operation, so that the data acquisition system can obtain the target eye tissue data of the eye part under the action of the excitation system; The data processing system communicates with the data acquisition system, and is used to obtain the target eye tissue data collected by the data acquisition system, and determine the mechanical characteristic parameters of the eye part according to the target eye tissue data.

8. The system according to claim 7, characterized in that The excitation system includes: a signal generator, a power amplifier and an electromagnetic coil; Wherein, the signal generator is connected to the power amplifier and is used to apply an initial voltage signal; The power amplifier is used to amplify the initial voltage signal to obtain a target voltage signal, so that the target voltage signal acts on the electromagnetic coil; The electromagnetic coil is used to convert the target voltage signal into magnetic field information.

9. The system according to claim 7, wherein: Also includes: Mixing the magnetic nanoparticle solution to be treated with buffered saline and centrifuging the solution to obtain the magnetic nanoparticle solution; Injecting or dripping the magnetic nanoparticle solution into the cornea, sclera, lens, ciliary muscle and / or retina of the eye; When it is detected that the diffusion time of the magnetic nanoparticle solution in the eye part reaches a preset time threshold, the excitation system and the data acquisition system are controlled to be in working state, so that the target eye tissue data when the excitation system acts on the eye part is collected based on the data acquisition system.

10. The system according to claim 7, wherein: The data acquisition system is a system that can track particle vibration amplitude within the micrometer and / or nanometer range, and the diameter of the magnetic nanoparticles is nanometer-scale.

11. An electronic device, characterized in that: include: one or more processors; a memory for storing one or more programs; When the one or more programs are executed by the one or more processors, the one or more processors implement the method for determining eye tissue information according to any one of claims 1 to 6.

12. A storage medium comprising computer executable instructions, wherein when the computer executable instructions are executed by a computer processor, the computer executable instructions are used to perform the method for determining eye tissue information according to any one of claims 1 to 6.

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