A method and application for detecting the performance of imaging probe labeling

Abstract

The invention discloses a method and application for detecting the marking performance of an imaging probe, comprising a detection box, wherein a marking cavity is arranged in the detection box, and a top seat is fixedly arranged on the upper end surface of the detection box; the invention judges the strength of the marking performance of the probe by comparing the strength of the fluorescence emitted by the probe with the total weight of the probe, and the detection method is not affected by the number of probes, thereby improving the detection accuracy, and also utilizes extendable bristles to clean the surface of the fluorescence detector to prevent the detection result from being affected by the attachment of debris to the surface, and because the bristles are only extended at the fluorescence detector, the loss of the bristles is reduced, and not only that, the stirring rod is repeatedly raised and lowered by an electromagnet, thereby increasing the stirring range and improving the stirring effect, and utilizing the power of stirring to grind the probe to increase the contact area of ​​the probe.

Description

Technical Field

[0001] The present invention relates to the technical field of molecular biology, and in particular to a method and application for detecting the labeling performance of an imaging probe. Background Art

[0002] Imaging probes, also known as molecular probes, are functional substances that can accurately answer biomedical questions. The labeling performance of imaging probes often directly affects the usability of imaging probes. However, there is no device in existing equipment that can detect the labeling performance of imaging probes. In addition, when imaging probes are dissolved and labeled, impurities in the solution may adhere to the detector, affecting the detection accuracy. Summary of the invention

[0003] The purpose of the present invention is to solve the above technical problems and provide a method and application for detecting the labeling performance of an image probe, so as to realize the detection of the labeling performance of the image probe and accelerate the probe labeling speed.

[0004] The technical solution adopted by the present invention is:

[0005] A method and application for detecting the marking performance of an imaging probe, comprising a detection box, wherein a marking cavity is provided in the detection box, a top seat is fixedly provided on the upper end surface of the detection box, a feed port opening upward is provided on the upper end surface of the top seat, a centrifugal cavity communicating with the feed port and the marking cavity is provided at the lower side of the feed port, a mark detection cavity is provided in the detection box on the left side of the marking cavity, and a mark detection mechanism for detecting the marking performance of the probe is provided in the centrifugal cavity, the detection box and the mark detection cavity; a main motor is fixedly provided in the detection box at the lower side of the marking cavity, a central axis extending into the centrifugal cavity is provided in the main motor, a liquid inlet pipe extending to the outside of the detection box is provided on the right side wall of the marking cavity, a one-way valve is fixedly provided on the liquid inlet pipe, an annular groove opening upward is provided on the bottom surface of the marking cavity, a connecting rod is fixedly provided on the central axis in the annular groove, a bottom slider rotatable in the annular groove is fixedly provided on the connecting rod, a cleaning block is fixedly provided on the upper end surface of the bottom slider, and a cleaning mechanism for cleaning the inner wall is provided in the cleaning block.

[0006] Preferably, in the above solution, two mercury lamps symmetrically positioned left and right are fixedly provided on the upper side wall of the marking cavity, and the mercury lamps can make the probe emit fluorescence.

[0007] Preferably, in the above scheme, the mark detection mechanism includes a centrifugal grinding wheel fixedly arranged on the upper end face of the central axis, a weight sensor is fixedly arranged on the upper end face of the centrifugal grinding wheel, a weight wire is connected to the lower end face of the weight sensor, a fluorescence detector is fixedly arranged on the right side wall of the mark cavity, a fluorescence wire is connected to the right end face of the fluorescence detector, a pointer cavity with an opening facing left is arranged in the detection box on the left side of the mark detection cavity, a scale is fixedly arranged on the inner wall of the pointer cavity, a pointer shaft extending into the pointer cavity is rotatably arranged on the right side wall of the mark detection cavity, two detection power wheels symmetrically positioned on the left and right are rotatably arranged on the pointer shaft in the mark detection cavity, an annular cavity is arranged in the detection power wheel, and the inner wall of the annular cavity is connected to the pointer A ratchet group is provided on the shaft, a pointer is fixedly provided on the pointer shaft in the pointer cavity, two detection power slide grooves corresponding to the position of the detection power wheel but symmetrical in front and back positions are provided in the detection box on the front and rear sides of the mark detection cavity, a detection slider is slidably provided in the detection power slide groove, a detection spring is fixedly provided between the detection slider and the inner wall of the detection power slide groove, a pull rope is connected between the detection slider and the corresponding detection power wheel, a detection electromagnet is fixedly provided in the detection box outside the detection power slide groove, the weight wire is connected to the detection electromagnet on the front side, and the fluorescent wire is connected to the detection electromagnet on the rear side. The mark detection mechanism can check the strength of the probe marking performance and will not be affected by the number of probes.

[0008] Preferably, in the above scheme, the detection power wheel on the right side can only drive the pointer shaft to rotate clockwise, and the detection power wheel on the left side can only drive the pointer shaft to rotate counterclockwise, and a torsion spring is fixed between the detection power wheel and the pointer shaft, which can reset the detection power wheel.

[0009] Preferably, in the above scheme, the cleaning mechanism includes a cleaning storage cavity arranged on the left end face of the cleaning block and opening to the left, two cleaning magnets symmetrically positioned up and down are slidably arranged in the cleaning storage cavity, a cleaning spring is fixed between the left end face of the cleaning magnet and the inner wall of the cleaning storage cavity, a commercial cleaning moving block is fixed between the two cleaning magnets, bristles are fixed on the left end face of the cleaning moving block, and two symmetrical permanent magnets are fixed in the detection sliders on the upper and lower sides of the fluorescence detector. The cleaning mechanism can clean the surface of the fluorescence detector to prevent the detection result from being affected by debris attached to the surface, and because the bristles only extend out at the fluorescence detector, the loss of the bristles is reduced.

[0010] Preferably, in the above scheme, two symmetrically positioned intermittent slide grooves with openings facing outward are provided on the left and right end faces of the central axis, an intermittent slider is slidably provided in the intermittent slide groove, an intermittent spring is fixed between the upper end face of the intermittent slider and the inner wall of the intermittent slide groove, a stirring rod is fixed on the outer end face of the intermittent slider, and an intermittent electromagnet is fixed in the central axis on the upper side of the intermittent slide groove, the intermittent electromagnet can drive the stirring rod to perform lifting motion, thereby increasing the stirring range.

[0011] Preferably, in the above solution, a grinding plate is fixedly provided on the inner wall of the centrifugal chamber outside the centrifugal grinding wheel, and the grinding plate can increase the contact area of ​​the probe.

[0012] Preferably, in the above scheme, the upper side wall of the centrifugal chamber is provided with two closed slide grooves which are symmetrically positioned on the left and right and open downwardly, a closed slider is slidably provided in the closed slide groove, a closed spring is fixed between the outer end surface of the closed slider and the inner wall of the closed slide groove, and a closed plate is fixed on the lower end surface of the closed slider, which can prevent the external environment from affecting the detection results.

[0013] The beneficial effects of the present invention are as follows: the present invention determines the strength of the probe labeling performance by comparing the intensity of the fluorescence emitted by the probe with the total weight of the probe, and this detection method is not affected by the number of probes, thereby improving the detection accuracy;

[0014] The present invention uses extendable bristles to clean the surface of the fluorescence detector to prevent debris from adhering to the surface and affecting the detection result. In addition, because the bristles are only extended at the fluorescence detector, the loss of the bristles is reduced.

[0015] The present invention drives the stirring rod to rise and fall repeatedly by means of an electromagnet, thereby increasing the stirring range and improving the stirring effect, and utilizing the stirring power to grind the probe and increase the contact area of ​​the probe. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the appearance of the present invention;

[0017] Figure 2 It is a schematic diagram of an imaging probe labeling performance detection method and an overall application structure of the present invention;

[0018] Figure 3 The present invention Figure 2 Schematic diagram of AA in the middle;

[0019] Figure 4 The present invention Figure 2 Schematic diagram of the middle BB;

[0020] Figure 5 The present invention Figure 2 The structural diagram of the cleaning block;

[0021] As shown in the figure:

[0022] 11. Top seat; 12. Feeding port; 13. Closed slider; 14. Closed chute; 15. Closed spring; 16. Closed plate; 17. Weight sensor; 18. Weight wire; 19. Centrifugal grinding wheel; 20. Center axis; 21. Intermittent electromagnet; 22. Intermittent spring; 23. Intermittent chute; 24. Intermittent slider; 25. Stirring rod; 26. Mercury lamp; 27. Grinding plate; 28. Liquid inlet pipe; 29. ​​Permanent magnet; 30. Fluorescence detector; 31. Fluorescence wire; 32. Ring groove; 33. Connecting rod; 34. Bottom slider; 35. Cleaning block ; 36. Main motor; 37. Mark detection chamber; 38. Pointer chamber; 39. Dial; 40. Detection box; 41. Detection power slide; 42. Detection electromagnet; 43. Detection spring; 44. Detection slider; 45. Pull rope; 46. Pointer shaft; 47. Pointer; 48. Detection power wheel; 49. Annular chamber; 50. Ratchet assembly; 51. Cleaning storage chamber; 52. Cleaning spring; 53. Cleaning magnet; 54. Cleaning moving block; 55. Bristles; 56. Cleaning mechanism; 57. Mark detection mechanism; 58. Centrifugal chamber; 59. Marking chamber. DETAILED DESCRIPTION

[0023] In order to make the purpose and advantages of the present invention more clearly understood, the present invention is specifically described in conjunction with the embodiments below. It should be understood that the following text is only used to describe an image probe marking performance detection method and application or several specific implementation methods of the present invention, and does not strictly limit the scope of protection of the specific request of the present invention. As used in this article, the terms up and down and left and right are not limited to their strict geometric definitions, but include tolerances for reasonable and inconsistent machining or human errors. The specific features of the image probe marking performance detection method and application are described in detail below:

[0024] Reference Figure 1-Figure 5According to an embodiment of the present invention, an imaging probe marking performance detection method and application includes a detection box 40, wherein a marking cavity 59 is provided in the detection box 40, a top seat 11 is fixedly provided on the upper end surface of the detection box 40, and a feed port 12 with an upward opening is provided on the upper end surface of the top seat 11, and a centrifugal cavity 58 is provided on the lower side of the feed port 12 and is connected to the feed port 12 and the marking cavity 59 at the same time, and a marking detection cavity 37 is provided in the detection box 40 on the left side of the marking cavity 59, and a marking detection mechanism 57 for detecting the marking performance of the probe is provided in the centrifugal cavity 58, the detection box 40 and the marking detection cavity 37; and a marking cavity 59 is provided on the lower side of the marking cavity 59. A main motor 36 is fixedly provided in the detection box 40, and a central axis 20 extending into the centrifugal chamber 58 is provided in the main motor 36. A liquid inlet pipe 28 extending to the outside of the detection box 40 is provided on the right side wall of the marking chamber 59, and a one-way valve is fixedly provided on the liquid inlet pipe 28. An annular groove 32 with an opening facing upward is provided on the bottom surface of the marking chamber 59, and a connecting rod 33 is fixedly provided on the central axis 20 in the annular groove 32. A bottom slider 34 rotatable in the annular groove 32 is fixedly provided on the connecting rod 33, and a cleaning block 35 is fixedly provided on the upper end surface of the bottom slider 34, and a cleaning mechanism 56 for cleaning the inner wall is provided in the cleaning block 35.

[0025] Advantageously or illustratively, two mercury lamps 26 symmetrically positioned left and right are fixedly provided on the upper side wall of the marking cavity 59. When the mercury lamps 26 are started, the mercury lamps 26 irradiate ultraviolet light into the marking cavity 59, causing the probe in the marking cavity 59 to emit fluorescence.

[0026] Advantageously or exemplarily, the mark detection mechanism 57 includes a centrifugal grinding wheel 19 fixedly arranged on the upper end surface of the central shaft 20, a weight sensor 17 is fixedly arranged on the upper end surface of the centrifugal grinding wheel 19, a weight wire 18 is connected to the lower end surface of the weight sensor 17, a fluorescence detector 30 is fixedly arranged on the right side wall of the mark cavity 59, a fluorescence wire 31 is connected to the right end surface of the fluorescence detector 30, a pointer cavity 38 with an opening facing left is arranged in the detection box 40 on the left side of the mark detection cavity 37, a dial 39 is fixedly arranged on the inner wall of the pointer cavity 38, a pointer shaft 46 extending into the pointer cavity 38 is rotatably arranged on the right side wall of the mark detection cavity 37, and the pointer shaft 46 in the mark detection cavity 37 is rotatably arranged. Two detection power wheels 48 symmetrically positioned left and right are rotatably provided on 46, an annular cavity 49 is provided in the detection power wheel 48, a ratchet group 50 is provided on the inner wall of the annular cavity 49 and the pointer shaft 46, a pointer 47 is fixedly provided on the pointer shaft 46 in the pointer cavity 38, two detection power slide grooves 41 corresponding to the position of the detection power wheel 48 but symmetrically positioned front and back are provided in the detection box 40 on the front and rear sides of the mark detection cavity 37, a detection slider 44 is slidably provided in the detection power slide groove 41, a detection spring 43 is fixedly provided between the detection slider 44 and the inner wall of the detection power slide groove 41, a pull rope 45 is connected between the detection slider 44 and the corresponding detection power wheel 48, and the detection power A detection electromagnet 42 is fixedly arranged in the detection box 40 outside the slide slot 41, the weight wire 18 is connected to the detection electromagnet 42 on the front side, and the fluorescent wire 31 is connected to the detection electromagnet 42 on the rear side. When a certain amount of probes are set on the weight sensor 17, the weight sensor 17 will weigh the weight of the probes and adjust the power of the front detection electromagnet 42 according to the weight, that is, the greater the weight, the greater the displacement distance of the detection slider 44 on the front side. At this time, the detection slider 44 will drive the detection power wheel 48 on the right side to rotate clockwise through the pull rope 45, and the detection power wheel 48 on the right side will drive the pointer 47 to rotate clockwise through the pointer shaft 46, and then start the main motor 36, and the main motor 36 drives the central shaft 20 to drive the pointer 47 to rotate clockwise. The dynamic centrifugal grinding wheel 19 rotates, and the probe on the weight sensor 17 is evenly sprinkled into the marking cavity 59 under the action of centrifugation. After the probe enters the cell and the marking is completed, the mercury lamp 26 is started to make the probe emit fluorescence. At this time, the fluorescence detector 30 will detect the brightness of the fluorescence emitted in the marking cavity 59, and adjust the power of the rear detection electromagnet 42 according to the brightness of the fluorescence, that is, the more the number of marks, the greater the brightness of the fluorescence, and the greater the displacement of the rear detection slider 44, so that the rear detection slider 44 drives the left detection power wheel 48 to rotate counterclockwise through the pull rope 45, and the left detection power wheel 48 drives the pointer 47 to rotate counterclockwise through the pointer shaft 46. At this time, the worse the marking performance of the probe, the greater the value of the pointer 47 at the dial 39 will be.

[0027] Beneficially or exemplarily, the detection power wheel 48 on the right side can only drive the pointer shaft 46 to rotate clockwise, and the detection power wheel 48 on the left side can only drive the pointer shaft 46 to rotate counterclockwise, and a torsion spring is fixed between the detection power wheel 48 and the pointer shaft 46. When the detection slider 44 is reset, the detection power wheel 48 can return to its initial state under the action of the torsion spring.

[0028] Beneficially or exemplarily, the cleaning mechanism 56 includes a cleaning storage chamber 51 which is arranged on the left end face of the cleaning block 35 and opens to the left, and two cleaning magnets 53 with symmetrical upper and lower positions are slidably arranged in the cleaning storage chamber 51, a cleaning spring 52 is fixedly arranged between the left end face of the cleaning magnet 53 and the inner wall of the cleaning storage chamber 51, a commercial cleaning moving block 54 is fixed between the two cleaning magnets 53, and a bristle 55 is fixedly arranged on the left end face of the cleaning moving block 54, and two symmetrical permanent magnets 29 are fixedly arranged in the detection sliders 44 on the upper and lower sides of the fluorescence detector 30, when the central shaft 20 rotates, the central shaft 20 drives the bottom slider 34 to rotate through the connecting rod 33, and the bottom slider 34 drives the cleaning block 35 to rotate, and when the cleaning block 35 rotates to a position close to the permanent magnet 29, the permanent magnet 29 attracts the cleaning magnet 53, and the cleaning magnet 53 drives the cleaning moving block 54 to move, and the cleaning moving block 54 allows the bristles 55 to extend out of the cleaning block 35, and the bristles 55 clean the surface of the fluorescence detector 30.

[0029] Beneficially or exemplarily, two intermittent grooves 23 with symmetrical positions and openings facing outward are provided on the left and right end faces of the central shaft 20, an intermittent slider 24 is slidably provided in the intermittent groove 23, an intermittent spring 22 is fixedly provided between the upper end face of the intermittent slider 24 and the inner wall of the intermittent groove 23, a stirring rod 25 is fixedly provided on the outer end face of the intermittent slider 24, and an intermittent electromagnet 21 is fixedly provided in the central shaft 20 on the upper side of the intermittent groove 23. When the main motor 36 drives the central shaft 20 to rotate, the central shaft 20 drives the stirring rod 25 to rotate, and the stirring rod 25 stirs the marking cavity 59. While the stirring rod 25 stirs, the intermittent electromagnet 21 is intermittently energized, so that the intermittent slider 24 is repeatedly raised and lowered.

[0030] Beneficially or exemplarily, a grinding plate 27 is fixedly provided on the inner wall of the centrifugal chamber 58 outside the centrifugal grinding wheel 19. When the probe on the weight sensor 17 is thrown out under the action of centrifugal force, the probe will fall into the narrow gap between the centrifugal grinding wheel 19 and the inner wall of the centrifugal chamber 58, and then after being ground by the rotating centrifugal grinding wheel 19 and the grinding plate 27, the probe falls into the marking chamber 59.

[0031] Beneficially or exemplarily, the upper side wall of the centrifugal chamber 58 is provided with two closed slide grooves 14 which are symmetrically positioned on the left and right and open downwardly, and a closed slider 13 is slidably arranged in the closed slide groove 14, and a closed spring 15 is fixedly arranged between the outer end surface of the closed slider 13 and the inner wall of the closed slide groove 14, and a closed plate 16 is fixedly arranged on the lower end surface of the closed slider 13. When the closed slider 13 is energized, the two closed sliders 13 will repel each other, so that the closed slider 13 drives the closed plate 16 to move outward, and the feed port 12 is connected with the centrifugal chamber 58.

[0032] The present invention provides an imaging probe labeling performance detection method and application, and its workflow is as follows:

[0033] Step 1: First, the closed slider 13 is controlled to be energized. The two closed sliders 13 will repel each other, so that the closed slider 13 drives the closed plate 16 to move outward, so that the feed port 12 is connected with the centrifugal chamber 58. When a certain amount of probes are set on the weight sensor 17, the weight sensor 17 will weigh the weight of the probes and adjust the power of the front detection electromagnet 42 according to the weight. That is, the greater the weight, the greater the displacement distance of the front detection slider 44. At this time, the detection slider 44 will drive the detection power wheel 48 on the right side through the pull rope 45. Rotate clockwise, the detection power wheel 48 on the right drives the pointer 47 to rotate clockwise through the pointer shaft 46, and then start the main motor 36. The main motor 36 drives the centrifugal grinding wheel 19 to rotate through the central shaft 20, so that when the probe on the weight sensor 17 is thrown out under the action of centrifugal force, the probe will fall into the slit between the centrifugal grinding wheel 19 and the inner wall of the centrifugal chamber 58, and then after being ground by the rotating centrifugal grinding wheel 19 and the grinding plate 27, the probe falls into the marking chamber 59, thereby increasing the contact area of ​​the probe and improving the marking speed of the probe.

[0034] Step 2: While the centrifugal grinding wheel 19 is rotating, the central shaft 20 drives the stirring rod 25 to rotate, and the stirring rod 25 stirs the marking chamber 59, and the intermittent electromagnet 21 is intermittently energized, so that the intermittent slider 24 is repeatedly raised and lowered to increase the stirring range. After the probe enters the cell and the marking is completed, the mercury lamp 26 is started to make the probe emit fluorescence. At this time, the fluorescence detector 30 will detect the brightness of the fluorescence emitted in the marking chamber 59, and adjust the power of the rear detection electromagnet 42 according to the brightness of the fluorescence, that is, the more the number of marks, the greater the brightness of the fluorescence, and the greater the displacement of the rear detection slider 44, so that the rear detection slider 44 drives the left detection power wheel 48 to rotate counterclockwise through the pull rope 45, and the left detection power wheel 48 drives the pointer 47 to rotate counterclockwise through the pointer shaft 46. At this time, the worse the marking performance of the probe, the larger the value of the pointer 47 at the dial 39 will be. Conversely, the better the marking performance of the probe, the smaller the value of the pointer 47 will be.

[0035] Step 3: While the central shaft 20 rotates, the central shaft 20 drives the bottom slider 34 to rotate through the connecting rod 33, and the bottom slider 34 drives the cleaning block 35 to rotate. When the cleaning block 35 rotates to a position close to the permanent magnet 29, the permanent magnet 29 attracts the cleaning magnet 53, and the cleaning magnet 53 drives the cleaning moving block 54 to move. The cleaning moving block 54 allows the bristles 55 to extend out of the cleaning block 35, and the bristles 55 clean the surface of the fluorescence detector 30 to prevent the fluorescence detector 30 from detecting results due to debris attached to the surface, and because the bristles 55 only extend from the fluorescence detector 30, the loss of the bristles 55 is reduced.

[0036] The above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the same. Although the present invention has been described in detail with reference to the above embodiments, a person skilled in the art should understand that the specific implementation modes of the present invention can still be modified or replaced by equivalents, and any modification or equivalent replacement that does not depart from the spirit and scope of the present invention should be included in the scope of the claims of the present invention.

Claims

1. An image probe marking performance detection machine, characterized in that: The detection machine comprises a detection box (40), wherein a marking chamber (59) is provided in the detection box (40), a top seat (11) is fixedly provided on the upper end surface of the detection box (40), a feed port (12) with an upward opening is provided on the upper end surface of the top seat (11), a centrifugal chamber (58) which is in communication with the feed port (12) and the marking chamber (59) is provided on the lower side of the feed port (12), a marking detection chamber (37) is provided in the detection box (40) on the left side of the marking chamber (59), two mercury lamps (26) are fixedly provided on the upper side wall of the marking chamber (59) in symmetrical positions on the left and right, and a marking detection mechanism (57) for detecting the marking performance of a probe is provided in the centrifugal chamber (58), the detection box (40) and the marking detection chamber (37); the marking chamber (59) ) is fixedly provided in the detection box (40) at the lower side thereof, and a central axis (20) extending into the centrifugal chamber (58) is provided in the main motor (36), and a liquid inlet pipe (28) extending to the outside of the detection box (40) is provided on the right side wall of the marking chamber (59), and a one-way valve is fixedly provided on the liquid inlet pipe (28), and an annular groove (32) with an opening facing upward is provided on the bottom surface of the marking chamber (59), and a connecting rod (33) is fixedly provided on the central axis (20) in the annular groove (32), and a bottom slider (34) rotatable in the annular groove (32) is fixedly provided on the connecting rod (33), and a cleaning block (35) is fixedly provided on the upper end surface of the bottom slider (34), and a cleaning mechanism (56) for cleaning the inner wall is provided in the cleaning block (35).

2. The image probe marking performance detection machine according to claim 1, characterized in that: The mark detection mechanism (57) comprises a centrifugal grinding wheel (19) fixedly arranged on the upper end surface of the central shaft (20); a grinding plate (27) is fixedly arranged on the inner wall of the centrifugal chamber (58) outside the centrifugal grinding wheel (19); a weight sensor (17) is fixedly arranged on the upper end surface of the centrifugal grinding wheel (19); a weight wire (18) is connected to the lower end surface of the weight sensor (17); a fluorescence detector (30) is fixedly arranged on the right side wall of the mark chamber (59); a fluorescence wire (31) is connected to the right end surface of the fluorescence detector (30); a pointer chamber (38) with an opening facing left is arranged in the detection box (40) on the left side of the mark detection chamber (37); a scale plate (39) is fixedly arranged on the inner wall of the pointer chamber (38); a pointer shaft (46) extending into the pointer chamber (38) is rotatably arranged on the right side wall of the mark detection chamber (37); and two detection power wheels (48) symmetrically positioned left and right are rotatably arranged on the pointer shaft (46) in the mark detection chamber (37).

3. The image probe marking performance detection machine according to claim 2, characterized in that: An annular cavity (49) is provided in the detection power wheel (48), a ratchet group (50) is provided on the inner wall of the annular cavity (49) and the pointer shaft (46), a pointer (47) is fixedly provided on the pointer shaft (46) in the pointer cavity (38), two detection power slide grooves (41) corresponding to the position of the detection power wheel (48) but symmetrical in front and back positions are provided in the detection box (40) on the front and back sides of the mark detection cavity (37), and a detection slider (44) is slidably provided in the detection power slide groove (41). ), a detection spring (43) is fixedly provided between the detection slider (44) and the inner wall of the detection power slide groove (41), a pull rope (45) is connected between the detection slider (44) and the corresponding detection power wheel (48), a detection electromagnet (42) is fixedly provided in the detection box (40) outside the detection power slide groove (41), the weight wire (18) is connected to the detection electromagnet (42) on the front side, and the fluorescent wire (31) is connected to the detection electromagnet (42) on the rear side.

4. The image probe marking performance detection machine according to claim 3, characterized in that: The detection power wheel (48) on the right side can only drive the pointer shaft (46) to rotate clockwise, and the detection power wheel (48) on the left side can only drive the pointer shaft (46) to rotate counterclockwise, and a torsion spring is fixedly provided between the detection power wheel (48) and the pointer shaft (46).

5. The image probe marking performance detection machine according to claim 3, characterized in that: The cleaning mechanism (56) comprises a cleaning storage chamber (51) which is arranged on the left end surface of the cleaning block (35) and opens to the left. Two cleaning magnets (53) are slidably arranged in the cleaning storage chamber (51) and are symmetrical in position up and down. A cleaning spring (52) is fixedly arranged between the left end surface of the cleaning magnet (53) and the inner wall of the cleaning storage chamber (51). A commercial cleaning moving block (54) is fixedly arranged between the two cleaning magnets (53). A brush (55) is fixedly arranged on the left end surface of the cleaning moving block (54). Two permanent magnets (29) are fixedly arranged in symmetrical positions in the detection sliders (44) on the upper and lower sides of the fluorescence detector (30).

6. The image probe marking performance detection machine according to claim 1, characterized in that: Two intermittent slide grooves (23) symmetrically positioned and open outward are provided on the left and right end surfaces of the central shaft (20); an intermittent slider (24) is slidably provided in the intermittent slide groove (23); an intermittent spring (22) is fixedly provided between the upper end surface of the intermittent slider (24) and the inner wall of the intermittent slide groove (23); a stirring rod (25) is fixedly provided on the outer end surface of the intermittent slider (24); and an intermittent electromagnet (21) is fixedly provided in the central shaft (20) on the upper side of the intermittent slide groove (23).

7. The image probe marking performance detection machine according to claim 1, characterized in that: The upper side wall of the centrifugal chamber (58) is provided with two closed slide grooves (14) which are symmetrically positioned on the left and right and open downwardly. A closed slider (13) is slidably arranged in the closed slide groove (14). A closed spring (15) is fixedly arranged between the outer end surface of the closed slider (13) and the inner wall of the closed slide groove (14). A closed plate (16) is fixedly arranged on the lower end surface of the closed slider (13).

8. A detection method for an image probe marking performance detection machine according to any one of claims 1 to 7, characterized in that: The testing process is as follows: The first step: first, the closed slider (13) is controlled to be energized, and the two closed sliders (13) will repel each other, so that the closed slider (13) drives the closed plate (16) to move outward, so that the feed port (12) is connected with the centrifugal chamber (58). When a certain amount of probes are set on the weight sensor (17), the weight sensor (17) will weigh the weight of the probes and adjust the power of the front detection electromagnet (42) according to the weight. That is, the greater the weight, the greater the displacement distance of the front detection slider (44). At this time, the detection slider (44) will drive the detection power wheel (48) on the right side through the pull rope (45). The detection power wheel (48) on the right side drives the pointer (47) to rotate clockwise through the pointer shaft (46), and then the main motor (36) is started. The main motor (36) drives the centrifugal grinding wheel (19) to rotate through the central shaft (20), so that when the probe on the weight sensor (17) is thrown out under the action of centrifugal force, the probe will fall into the slit between the centrifugal grinding wheel (19) and the inner wall of the centrifugal chamber (58), and then after being ground by the rotating centrifugal grinding wheel (19) and the grinding plate (27), the probe falls into the marking chamber (59), thereby increasing the contact area of ​​the probe and improving the marking speed of the probe; Step 2: While the centrifugal grinding wheel (19) is rotating, the central shaft (20) drives the stirring rod (25) to rotate, and the stirring rod (25) stirs the labeling chamber (59), and the intermittent electromagnet (21) is intermittently energized, so that the intermittent slider (24) is repeatedly raised and lowered to increase the stirring range. After the probe enters the cell and the labeling is completed, the mercury lamp (26) is started to make the probe emit fluorescence. At this time, the fluorescence detector (30) detects the brightness of the fluorescence emitted in the labeling chamber (59) and adjusts the brightness according to the brightness of the fluorescence. The power of the detection electromagnet (42) on the side, that is, the greater the number of marks, the greater the brightness of the fluorescence, and the greater the displacement of the detection slider (44) on the rear side, so that the detection slider (44) on the rear side drives the detection power wheel (48) on the left side to rotate counterclockwise through the pull rope (45), and the detection power wheel (48) on the left side drives the pointer (47) to rotate counterclockwise through the pointer shaft (46). At this time, the worse the marking performance of the probe, the greater the value of the pointer (47) at the scale (39). Conversely, the better the marking performance of the probe, the smaller the value of the pointer (47); Step 3: While the central shaft (20) is rotating, the central shaft (20) drives the bottom slider (34) to rotate through the connecting rod (33), and the bottom slider (34) drives the cleaning block (35) to rotate. When the cleaning block (35) rotates to a position close to the permanent magnet (29), the permanent magnet (29) attracts the cleaning magnet (53), and the cleaning magnet (53) drives the cleaning moving block (54) to move. The cleaning moving block (54) allows the bristles (55) to extend out of the cleaning block (35), and the bristles (55) clean the surface of the fluorescence detector (30), thereby preventing the fluorescence detector (30) from detecting a result due to debris attached to the surface. In addition, because the bristles (55) are only extended at the fluorescence detector (30), the loss of the bristles (55) is reduced.

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