A perfusion scanning and reconstruction method and apparatus

Abstract

The present application relates to a perfusion scanning and reconstruction method and apparatus. Among them, the method includes: selecting a plurality of reconstruction angle ranges from within the scanning angle range according to a preset threshold of the reconstruction time resolution; scanning a scanning object according to the scanning angle range, and respectively performing real-time reconstruction on the projection data obtained by scanning at the starting angles of the plurality of reconstruction angle ranges until the reconstruction of the projection data within the entire reconstruction angle range is completed. By using the technical solutions provided in the various embodiments of the present application, the utilization limit of the scanning angle range can be improved, and the relatively high requirements for the reconstruction time resolution in perfusion scanning can be met.

Description

Technical Field

[0001] This application relates to the field of medical technology, and particularly to a perfusion scanning and reconstruction method and device. Background Art

[0002] Perfusion imaging can reflect the blood flow microcirculation law of contrast agents in tissues or lesions, which is of great help for differentiating benign and malignant tumors and understanding the blood supply of cerebral ischemia lesions. Therefore, perfusion imaging is widely used in the diagnosis of various diseases. Perfusion imaging mainly includes two stages: perfusion scanning and perfusion reconstruction. Perfusion scanning refers to the process of continuously and rapidly scanning the region of interest after injecting contrast agents into the body and obtaining a series of images. Perfusion reconstruction refers to the process of determining the time-density change curves of each pixel in the image with the help of tools such as software, thereby calculating the peak time, mean transit time, local blood volume, and local blood flow of the contrast agent reaching the tissue or lesion, forming a new digital matrix, and then obtaining the perfusion image through digital-to-analog conversion.

[0003] Perfusion imaging often requires obtaining the reconstruction results during the period from the moment when the contrast agent enters the tissue or lesion until it leaves the tissue or lesion, and this period is short. In order to obtain more accurate reconstruction results, the methods in the related art often involve injecting contrast agents multiple times and performing multiple perfusion scans. However, injecting contrast agents multiple times may cause certain damage to the patient's body. Therefore, there is an urgent need in the related art for a perfusion scanning method that can reduce the number of contrast agent injections but still obtain relatively accurate reconstruction results. Summary of the Invention

[0004] Embodiments of this application provide a perfusion scanning and reconstruction method and device to at least solve the problem in the related art that perfusion scanning requires injecting contrast agents multiple times.

[0005] In a first aspect, embodiments of this application provide a perfusion scanning and reconstruction method, including:

[0006] Selecting a plurality of reconstruction angle ranges from within the scanning angle range according to a preset threshold of the reconstruction time resolution;

[0007] Scanning a scanning object according to the scanning angle range, and respectively performing real-time reconstruction on the projection data obtained by scanning at the starting angles of the plurality of reconstruction angle ranges until the reconstruction of the projection data within the entire reconstruction angle range is completed.

[0008] The perfusion scanning and reconstruction methods and devices provided by various embodiments of the present application can select multiple reconstruction angle ranges from the scanning angle range according to the requirements of the reconstruction time resolution, and make the most of the scanning angle range. Compared with the scanning and reconstruction methods in the related art, the methods or devices provided by various embodiments of the present application can obtain more reconstruction angles within the same scanning angle range, meet the higher requirements for the reconstruction time resolution in perfusion scanning. Moreover, it can reduce the scanning duration of the scanned object and greatly reduce the health impact on the scanned object. Specifically, if it is required to complete the scanning after obtaining a preset number of reconstruction results, then, due to the improvement of the reconstruction time resolution and the reduction of the duration required to obtain one reconstruction result, the scanning and reconstruction can be completed in a shorter duration, and thus the number of times of injecting contrast agent into the scanned object and the scanning radiation duration can be reduced.

[0009] Optionally, in an embodiment of the present application, the step of selecting multiple reconstruction angle ranges from the scanning angle range according to the preset requirements of the reconstruction time resolution includes:

[0010] Obtain the preset threshold of the reconstruction time resolution and the rotation speed of the scanning device;

[0011] Determine the upper limit value of the reconstruction angle step according to the preset threshold and the rotation speed;

[0012] Select multiple reconstruction angle ranges from the scanning angle range, and set the step between two adjacent reconstruction angle ranges to be not greater than the upper limit value of the reconstruction angle step.

[0013] Optionally, in an embodiment of the present application, the preset threshold of the reconstruction time resolution is obtained in the following manner:

[0014] Obtain the injection parameters of the perfusion contrast agent and / or different development stages, where the injection parameters include at least one of the concentration, injection volume, and injection speed of the perfusion contrast agent;

[0015] Determine the preset threshold of the reconstruction time resolution that matches the injection parameters and / or the different development stages.

[0016] Optionally, in an embodiment of the present application, the preset threshold of the reconstruction time resolution is obtained in the following manner:

[0017] Set the preset threshold of the reconstruction time resolution that matches the accuracy requirement according to the accuracy requirement of the perfusion parameters.

[0018] Optionally, in an embodiment of the present application, after completing the reconstruction of the projection data within the entire reconstruction angle range, the method further includes:

[0019] Displays the reconstruction result of the projection data within the reconstructed angle range.

[0020] Optionally, in an embodiment of the present application, the scanning angle range includes the maximum scanning range of the scanning device.

[0021] In a second aspect, an embodiment of the present application provides a perfusion scanning and reconstruction device, including:

[0022] A reconstruction angle selection module, configured to select multiple reconstructed angle ranges from the scanning angle range according to a preset threshold of the reconstruction time resolution;

[0023] A scanning and reconstruction module, configured to scan a scanning object according to the scanning angle range, and perform real-time reconstruction on the obtained projection data at the starting angles of the multiple reconstructed angle ranges until the reconstruction of the projection data within the entire reconstructed angle range is completed.

[0024] In a third aspect, an embodiment of the present application provides a processing device, including a memory and a processor. A computer program is stored in the memory, and the processor is configured to run the computer program to execute the perfusion scanning and reconstruction method.

[0025] In a fourth aspect, an embodiment of the present application provides a scanning device, characterized by including a gantry, a detector, and the processing device, wherein,

[0026] The detector is installed on the gantry and is configured to scan a scanning object;

[0027] The gantry is configured to drive the detector to rotate.

[0028] In a fifth aspect, an embodiment of the present application provides a computer storage medium, in which a computer program is stored. The computer program is configured to execute the perfusion scanning and reconstruction method when running.

[0029] In a sixth aspect, an embodiment of the present application provides a computer program product, including computer-readable code, or a non-volatile computer-readable storage medium carrying the computer-readable code. When the computer-readable code runs in the processor of an electronic device, the processor in the electronic device executes the perfusion scanning and reconstruction method.

[0030] Details of one or more embodiments of the present application are set forth in the following drawings and description to make other features, objects, and advantages of the present application more concise and understandable. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The accompanying drawings described herein are used to provide a further understanding of the present application, and form a part of the present application. The schematic embodiments of the present application and their descriptions are used to explain the present application, and do not constitute an improper limitation of the present application. In the drawings:

[0032] Figure 1 is a schematic diagram of an application scenario provided by an embodiment of the present application;

[0033] Figure 2 is a flowchart of a perfusion scanning and reconstruction method provided by an embodiment of the present application;

[0034] Figure 3 is a schematic diagram of an application scenario provided by an embodiment of the present application;

[0035] Figure 4 is a schematic diagram of an application scenario provided by an embodiment of the present application;

[0036] Figure 5 is a block diagram of a perfusion scanning and reconstruction device provided by an embodiment of the present application;

[0037] Figure 6 is a block diagram of a processing device provided by an embodiment of the present application;

[0038] Figure 7 is a block diagram of a computer program product provided by an embodiment of the present application. Detailed Embodiments

[0039] In order to make the objectives, technical solutions and advantages of the present application more clearly understood, the present application will be described and illustrated below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application, and are not used to limit the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments provided in the present application without making creative efforts fall within the scope of protection of the present application. In addition, it can also be understood that although the efforts made in this development process may be complex and time-consuming, for those of ordinary skill in the art related to the content disclosed in the present application, some design, manufacturing or production changes based on the technical content disclosed in the present application are only conventional technical means and should not be understood as insufficient disclosure of the content of the present application.

[0040] Referring to "embodiments" in the present application means that specific features, structures or characteristics described in connection with the embodiments can be included in at least one embodiment of the present application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those of ordinary skill in the art explicitly and implicitly understand that the embodiments described in the present application can be combined with other embodiments without conflict.

[0041] Unless otherwise defined, the technical terms or scientific terms involved in this application shall have the ordinary meanings understood by those with ordinary skills in the technical field to which this application belongs. The similar words such as "a", "an", "one kind", "the" involved in this application do not indicate a quantity limitation and may represent a singular or plural number. The terms "include", "comprise", "have" and any variations thereof involved in this application are intended to cover non-exclusive inclusion; for example, a process, method, system, product or device that includes a series of steps or modules (units) is not limited to the listed steps or units, but may further include steps or units not listed, or may further include other steps or units inherent to these processes, methods, products or devices. The similar words such as "connect", "be connected", "couple" involved in this application are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The "plurality" involved in this application means greater than or equal to two. "And / or" describes the association relationship of associated objects and indicates that three relationships may exist. For example, "A and / or B" may represent: A exists alone, A and B exist simultaneously, and B exists alone. The terms "first", "second", "third", etc. involved in this application are only used to distinguish similar objects and do not represent a specific order for the objects.

[0042] In addition, for better illustration of this application, numerous specific details are given in the following specific implementation manners. Those skilled in the art should understand that this application can still be implemented without certain specific details. In some instances, devices, means, elements and circuits well-known to those skilled in the art are not described in detail in order to highlight the gist of this application.

[0043] In order to clearly show the technical solutions of the various embodiments of this application, the technical environment of this application is described below.

[0044] The following is through Figure 1 to illustrate one exemplary scenario of the embodiments of this application.

[0045] Please refer to Figure 1 , Figure 1 is a schematic structural diagram of a scanning device 100 provided by an embodiment of this application. The scanning device 100 may include a device capable of performing perfusion scanning, and specifically may include an electromagnetic wave scanning device with a rotatable bracket, such as a cone beam computed tomography (CBCT) device with a C-shaped bracket, etc. This application does not limit this here. As Figure 1As shown, the scanning device 100 may include a scanning gantry 101 and a detector 103. Among them, the scanning gantry 101 is used to drive the detector 103 to rotate. For example, in CBCT, the scanning gantry 101 may include a C-shaped bracket. The rotation mode of the scanning gantry 101 may include longitudinal rotation. For example, when the patient lies on the scanning bed, the scanning gantry 101 drives the detector 103 to rotate around the scanning bed. Of course, the scanning gantry 101 may also rotate transversely. The rotation mode of the scanning gantry 101 is not limited herein. The detector 103 may be used to obtain projection data of the scanned object. The detector 103 may include, for example, an X-ray emitter and a receiver. The obtained projection data may include a plurality of two-dimensional images collected by the detector 103 from the scanned object at a certain acquisition frequency. The three-dimensional reconstruction result can be reconstructed using the plurality of two-dimensional images.

[0046] An embodiment of the present application further provides a perfusion scanning and reconstruction device 105. The perfusion scanning and reconstruction device 105 may select a plurality of reconstruction angle ranges from the scanning angle range according to a preset threshold of the reconstruction time resolution. And scan the scanned object according to the scanning angle range, and perform real-time reconstruction on the obtained projection data at the starting angles of the plurality of reconstruction angle ranges respectively until the reconstruction of the projection data within the entire reconstruction angle range is completed. The perfusion scanning and reconstruction device 105 may include various forms such as a processing device, a non-volatile computer-readable storage medium, a computer program product, a chip, etc. As a processing device, the perfusion scanning and reconstruction device 105 may perform data transmission with the scanning device 100 and send information such as the set reconstruction scanning range to the scanning device 100. As a non-volatile computer-readable storage medium, a computer program product, a chip, the perfusion scanning and reconstruction device 105 may be coupled inside the scanning device 100, enabling the scanning device 100 to plan the function of the reconstruction scanning range. Of course, the perfusion scanning and reconstruction device 105 may also be set in other terminals (such as a smart phone) or a server or the cloud, and communicate with the scanning device 100 through network transmission and other means. The present application does not limit the product form of the perfusion scanning and reconstruction device 105.

[0047] The perfusion scanning and reconstruction method described in the present application will be described in detail below with reference to the accompanying drawings. Figure 2It is a schematic flowchart of an embodiment of the perfusion scanning and reconstruction method provided by this application. Although the method operation steps as shown in the following embodiments or drawings are provided by this application, more or fewer operation steps may be included in the method based on routine or non-creative labor. In steps where there is no necessary causal relationship logically, the execution order of these steps is not limited to the execution order provided by the embodiments of this application. During the actual perfusion scanning and reconstruction process or when the method is executed, the method may be executed in the order shown in the embodiments or drawings or in parallel (for example, in an environment of parallel processors or multi-threaded processing).

[0048] Specifically, as shown in an embodiment of the perfusion scanning and reconstruction method provided by this application Figure 2 The method may include:

[0049] S201: Select a plurality of reconstruction angle ranges from within the scanning angle range according to a preset threshold of the reconstruction time resolution.

[0050] In the embodiments of this application, the reconstruction time resolution may include the duration for obtaining one reconstruction result. For example, the reconstruction time resolution may include 2 seconds, that is, one reconstruction result is obtained every 2 seconds. Since the contrast agent flows relatively fast in the human body or animal body, it is a reasonable choice to set a higher requirement for the reconstruction time resolution. Then, obtaining the preset threshold of the reconstruction time resolution, that is, the longest duration for obtaining one reconstruction result. For example, if the preset threshold for obtaining the reconstruction time resolution is 3 seconds, then the longest duration for obtaining one reconstruction result is 3 seconds. In other words, at least one reconstruction result needs to be obtained every 3 seconds.

[0051] In an embodiment of this application, it may be set that the reconstruction time resolution is related to the injection rate of the perfusion contrast agent. Specifically, the preset threshold of the reconstruction time resolution may be obtained in the following manner:

[0052] S301: Obtain the injection parameters of the perfusion contrast agent and / or different development stages, where the injection parameters include at least one of the concentration, injection volume, and injection speed of the perfusion contrast agent;

[0053] S303: Determine the preset threshold of the reconstruction time resolution that matches the injection parameters and / or the different development stages.

[0054] Injecting the perfusion contrast agent into a human body or an animal body has certain injection parameters, and the injection parameters may include at least one of the concentration of the contrast agent, the injection volume, and the injection speed. Different injection parameters may result in different requirements for the reconstruction time resolution. Specifically, the contrast agent concentration can affect the imaging effect of the contrast agent in tissues or lesions. For example, for a contrast agent with a higher concentration, the imaging effect in tissues or lesions is more obvious. Therefore, a higher reconstruction time resolution can be set, and multiple high-quality reconstruction results can be obtained in a shorter time. Similarly, the injection volume can also affect the setting of the preset threshold of the reconstruction time resolution. Specifically, when the injection volume is small, it may be necessary to obtain scanning data in a shorter time, so a higher reconstruction time resolution needs to be set. The injection rate of the contrast agent is usually parameter values such as 1.5 ml / s and 2 ml / s. Correspondingly, at different injection rates, the flow rate of the contrast agent in tissues or lesions is different, and at this time, the user's requirements for the reconstruction time resolution may be different. For example, the faster the injection rate, the relatively higher the required time resolution, so that a reconstruction result can be obtained in a shorter time. Therefore, determining the preset threshold of the reconstruction time resolution according to the injection parameters is more in line with the actual needs of users.

[0055] Of course, the injection parameters of the contrast agent are not the only factor affecting the reconstruction temporal resolution. In the embodiments of the present application, the setting of the preset threshold of the reconstruction temporal resolution can also be matched with the development stage of the contrast agent. When the contrast agent is injected into the human body or an animal body, it usually needs to go through several development stages. In different development stages, the flow rate and development effect of the contrast agent are often different. For example, in one example, the development stage of the contrast agent can include the plain scan phase, the slow inflow phase, the high-dose arterial phase, the low-dose outflow phase, the slow outflow phase, etc. In the plain scan phase and the slow outflow phase, which are the start and end phases of the contrast agent entering the tissue or lesion, the flow rate is usually slow. Therefore, the preset threshold of the reconstruction scan temporal resolution can be set relatively low, such as 4-5 s. While the high-dose arterial phase is the stage where the contrast agent has the fastest flow rate. Therefore, the preset threshold of the reconstruction scan resolution can be set relatively high, such as 1.5-2 s. The flow rate of the contrast agent in the slow inflow phase and the low-dose outflow phase is between the above two stages. Therefore, the preset threshold of the scan resolution can be set between the above two values, such as 2-3 s. That is to say, by setting the preset threshold of the reconstruction temporal resolution to match the development stage of the contrast agent, based on the fact that the flow rate and development effect of the contrast agent are different in each development stage, the preset threshold of the reconstruction temporal resolution can also be different in each stage. Through such a setting method, the reconstruction temporal resolution can be flexibly adjusted, neither resulting in an inability to obtain high-quality reconstruction results due to too low a setting, nor causing excessive scanning radiation to the human body or animal body, thus affecting physical health.

[0056] In another embodiment of the present application, a preset threshold of the reconstruction time resolution that matches the accuracy requirement can also be set according to the accuracy requirement of the perfusion parameters. Compared with ordinary plain scans and enhanced scans that only collect data information at one time point, perfusion imaging obtains the time-density curve (TDC) of each voxel of a tissue or organ by continuously scanning multiple phases, reflects the inflow and outflow process (blood perfusion) of the contrast agent in the tissue or organ, and then calculates various perfusion parameters using different data models to form a perfusion parameter map. For example, in brain perfusion scanning, the perfusion parameters may include cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), and so on. The higher the reconstruction time resolution, the higher the accuracy of the generated perfusion parameters. Based on this, when the accuracy requirement for the perfusion parameters is higher, the reconstruction time resolution can be set larger. Among them, the accuracy requirement may include specific accuracy thresholds, such as threshold requirements of 96%, 98%, etc.

[0057] Of course, in other embodiments, the preset threshold of the reconstruction time resolution may also be related to factors such as the cardiac function of the human body or animal body, and the present application does not limit this here.

[0058] After obtaining the preset threshold of the reconstruction time resolution, multiple reconstruction angle ranges can be selected from within the scanning angle range. Among them, the scanning angle range may include the angle range for scanning the scanning object using a scanning device. Since the perfusion scans involved in the various embodiments of the present application may refer to static perfusion scans, a static perfusion scan means that during the perfusion scan, the scanning bed or the scanning object does not move, and only the detector rotates around the scanning object together with the scanning frame for scanning. Therefore, before scanning the scanning object, the scanning angle range of the detector can be set according to the structural characteristics of the scanning object or the region of interest. The scanning angle range may include any angle range greater than the reconstruction angle range, and the scanning angle range may include a limited angle range, such as 0-360°, 0-1080°, etc., or the specific range of the scanning angle range may not be limited, such as completing the scan after obtaining N reconstruction results, and the present application does not limit this here.

[0059] The reconstruction angle range in each embodiment of the present application may include the angle range of the projection data required to generate a reconstruction result. Numerically, the reconstruction angle range may be greater than the minimum reconstruction angle range. In some perfusion reconstruction methods, it is often necessary to set the minimum reconstruction angle range. For example, for the filtered backprojection reconstruction method, since the filtered backprojection reconstruction method is based on the Randon transform and the data of the Randon transform is a sinogram with a period of π, it is necessary to obtain the 180° line integral of each point in the reconstruction region (FOV) to complete the reconstruction. Based on the above theory, as Figure 3 shown, in CBCT scanning, only when the X-ray tube rotates around the FOV of the object to be scanned (the middle black circular area) by at least an angle, the entire FOV of the object to be scanned can be scanned by 180 degrees, that is, the entire FOV of the object to be scanned obtains 180 degrees of line integral projection data. Among them, as Figure 3 shown, the fan angle can be set according to the radius R of the FOV of the object to be scanned and the distance L between the X-ray tube and the center of the FOV of the object to be scanned, as Of course, in other embodiments, the reconstruction angle range may be determined according to a specific algorithm, and the present application does not limit this here.

[0060] In the embodiments of the present application, by selecting multiple reconstruction angle ranges from the scanning angle range, multiple reconstruction results can be obtained in one scan, improving the utilization rate of the scanning data. In one embodiment, multiple reconstruction angle ranges may be selected from the scanning angle range at a certain step size, where the step size may include the angular interval between two adjacent reconstruction angle ranges. For example, as Figure 4 shown, the scanning angle range is 0 - 360°, the length of the reconstruction angle range is (π + 20° = 200°), and the step size is set to 80°. Then, the selected reconstruction angle ranges are reconstruction angle range 1 (0 - 200°), reconstruction angle range 2 (80° - 280°), and reconstruction angle range 3 (160° - 360°). In the related art, the practice is to obtain one reconstruction result based on the projection data within the angle range of (0 - 200°), and then obtain the next reconstruction result based on the projection data within the next angle range (200° - 400°). In this way, it not only fails to meet the resolution requirements but also consumes more time.

[0061] Of course, in other embodiments, multiple reconstruction angle ranges may also be arbitrarily selected from the scanning angle range when the preset threshold of the reconstruction time resolution is satisfied, and the present application does not limit this here.

[0062] In one embodiment of the present application, the upper limit value of the step size of the reconstruction angle range can be determined according to the rotation speed of the scanning device. Specifically, the selecting multiple reconstruction angle ranges from the scanning angle range according to the preset requirements of the reconstruction time resolution may include:

[0063] S401: Obtain the preset threshold of the reconstruction time resolution and the rotation speed of the scanning device;

[0064] S403: Determine the upper limit value of the reconstruction angle step size according to the preset threshold and the rotation speed;

[0065] S405: Select multiple reconstruction angle ranges from the scanning angle range, and set the step size between two adjacent reconstruction angle ranges to be not greater than the upper limit value of the reconstruction angle step size.

[0066] In the embodiment of the present application, the upper limit value of the reconstruction angle step size can be determined according to the preset threshold of the reconstruction time resolution and the rotation speed of the scanning device. During the scanning process, the scanning device can rotate by itself at a certain rotation speed. This rotation speed can be an inherent parameter of the scanning device or can be manually set, and the present application does not limit this here. Then, according to the preset threshold and the rotation speed, the upper limit value of the reconstruction angle step size can be determined. In one example, the preset threshold of the reconstruction time resolution is 3s, and the rotation speed of the scanning device is 50° / s. Then, a reconstruction result needs to be obtained at least every (50° / s × 3s) = 150° angle. That is to say, the upper limit value of the reconstruction angle step size is 150°. After determining the upper limit value of the reconstruction angle step size, the step size of the multiple reconstruction angle ranges can be set, and the step size between two adjacent reconstruction angle ranges is made not greater than the upper limit value of the reconstruction angle step size. For the above example, the step size between two adjacent reconstruction angle ranges can be set to be not greater than 150°, for example, the step size of the reconstruction angle range can be set to values such as 150°, 120°, 100°.

[0067] According to the preset threshold of the reconstruction time resolution and the rotation speed of the scanning device, the upper limit value of the reconstruction angle step size can be determined, so as to determine the accurate step size of the reconstruction angle range and make the most of the projection data within the scanning angle range.

[0068] In an embodiment of the present application, the scanning angle range may include the maximum scanning range of the scanning device. The scanning device usually has a maximum scanning range. For example, for some CBCT devices, due to the device structure, the maximum scanning range may include 360°, 720°, etc. After the scanning device rotates to the maximum scanning range, it usually pauses scanning or continues scanning in another rotation direction. Then, taking the maximum scanning range of the scanning device as the scanning angle range enables the scanning device to continuously scan the scanning object to the maximum scanning range in one rotation direction, and can continuously plan as many of the reconstruction angle ranges as possible, stably meeting the requirements for the reconstruction time resolution.

[0069] S203: Scan the scanning object according to the scanning angle range, and perform real-time reconstruction on the acquired projection data at the starting angles of the multiple reconstruction angle ranges respectively until the reconstruction of the projection data within the entire reconstruction angle range is completed.

[0070] In the embodiment of the present application, after determining the multiple reconstruction angle ranges, the scanning object may be scanned according to the scanning angle range, and real-time reconstruction may be performed on the acquired projection data at the starting angles of the multiple reconstruction ranges respectively. In one example, for a scanning and reconstruction angle range where the scanning angle range is 0 - 360° and the reconstruction angle ranges are (0 - 200°), (80° - 280°), and (160° - 360°) respectively, for the first reconstruction angle range (0 - 200°), real-time reconstruction of the projection data within the (0 - 200°) angle range may be started at 0 degrees, so that the first reconstruction result can be obtained when the scanning device rotates to 200°. For the second reconstruction angle range (80° - 280°), real-time reconstruction of the projection data within the (80° - 280°) angle range may be performed when the scanning device rotates to 80°, so that the second reconstruction result can be obtained when the scanning device rotates to 280°. For the third reconstruction angle range (160° - 360°), real-time reconstruction of the projection data within the (160° - 360°) angle range may be performed when the scanning device rotates to 160°, so that the third reconstruction result can be obtained when the scanning device rotates to 360°.

[0071] It should be noted that in the embodiment of the present application, analytical algorithms such as two-dimensional filtered back projection reconstruction algorithm (Filtered Back Projection, FBP), three-dimensional FDK extended based on the FBP algorithm, etc. may be used to perform analytical reconstruction on the projection data within each of the above-mentioned reconstruction angle ranges to obtain the reconstruction result, and the present application does not limit the reconstruction algorithm.

[0072] It takes a certain amount of time for the scanning device to complete the rotation within the reconstruction angle range. Especially for some scanning devices with slow rotation speed, it often takes a longer time. Based on this, in order to associate the reconstruction result with a specific time point, in the embodiments of the present application, the scanning of the scanned object according to the scanning angle range may include:

[0073] S501: Record the corresponding moments when the scanning device rotates to the central angles of the multiple reconstruction angle ranges respectively;

[0074] S503: Use the moment as the reconstruction moment of the reconstruction result corresponding to the reconstruction angle range.

[0075] In the embodiments of the present application, during the rotation of the scanning device, the moments corresponding to the central angles of the multiple reconstruction angle ranges that the scanning device rotates to can be recorded respectively. In one example, for a scanning and reconstruction angle range where the scanning angle range is 0 - 360°, and the reconstruction angle ranges are (0 - 200°), (80° - 280°), and (160° - 360°) respectively, for the first reconstruction angle range (0 - 200°), the central angle is 100°, the moment 1 when the scanning device rotates to 100° can be recorded, and moment 1 is used as the reconstruction moment corresponding to the first reconstruction result. For the second reconstruction angle range (80° - 280°), the central angle is 180°, the moment 2 when the scanning device rotates to 180° can be recorded, and moment 2 is used as the reconstruction moment corresponding to the second reconstruction result. For the third reconstruction angle range (160° - 360°), the central angle is 260°, the moment 3 when the scanning device rotates to 260° can be recorded, and moment 3 is used as the reconstruction moment corresponding to the third reconstruction result. In this embodiment, by associating the reconstruction result with an accurate and specific moment, the data can be aligned with the specific time during subsequent data reconstruction. Of course, the reconstruction result corresponding to the reconstruction angle range can also correspond to other moments within the reconstruction angle range, such as the starting moment or the ending moment, as long as the setting method of the reconstruction moments corresponding to different reconstruction angle ranges is the same..

[0076] In the embodiments of the present application, after the reconstruction result is obtained, the reconstruction result of the projection data within the reconstruction angle range can be displayed. Specifically, after the reconstruction result is obtained, the reconstruction result can be displayed in real time. For example, for the reconstruction result obtained within the range of (0 - 200°), the reconstruction result corresponding to this range can be displayed in real time at the moment when the scanning device rotates to 200°. In this embodiment, after planning the reconstruction angle range according to the requirements of the reconstruction time resolution, the corresponding reconstruction result can be displayed in real time, improving the subsequent analysis efficiency.

[0077] The perfusion scanning and reconstruction methods provided by various embodiments of the present application can select multiple reconstruction angle ranges from the scanning angle range according to the requirements of the reconstruction time resolution, and make the most of the scanning angle range. Compared with the scanning and reconstruction methods in the related art, the methods provided by various embodiments of the present application can obtain more reconstruction angles within the same scanning angle range, meet the higher requirements for the reconstruction time resolution in perfusion scanning. Moreover, it can reduce the scanning duration of the scanned object and greatly reduce the health impact on the scanned object. Specifically, if it is required to obtain a preset number of reconstruction results to complete the scanning, then, due to the improvement of the reconstruction time resolution, the time required to obtain one reconstruction result is reduced, so the scanning and reconstruction can be completed in a shorter time, and thus the number of times of injecting contrast agent into the scanned object and the scanning radiation duration can be reduced.

[0078] In the above text, in combination with Figures 1 to 4 , the perfusion scanning and reconstruction methods provided by the present application are described in detail. Next, in combination with the attached Figure 5 , the perfusion scanning and reconstruction device 105 provided by the present application will be described, including:

[0079] A reconstruction angle selection module 501, configured to select multiple reconstruction angle ranges from the scanning angle range according to a preset threshold of the reconstruction time resolution;

[0080] A scanning and reconstruction module 503, configured to scan a scanned object according to the scanning angle range, and perform real-time reconstruction on the projection data obtained by scanning at the starting angles of the multiple reconstruction angle ranges respectively until the reconstruction of the projection data within the entire reconstruction angle range is completed.

[0081] Optionally, in an embodiment of the present application, the selecting multiple reconstruction angle ranges from the scanning angle range according to the preset requirements of the reconstruction time resolution includes:

[0082] Obtaining a preset threshold of the reconstruction time resolution and the rotation speed of the scanning device;

[0083] Determining an upper limit value of the reconstruction angle step according to the preset threshold and the rotation speed;

[0084] Selecting multiple reconstruction angle ranges from the scanning angle range, and setting the step between two adjacent reconstruction angle ranges to be not greater than the upper limit value of the reconstruction angle step.

[0085] Optionally, in an embodiment of the present application, the preset threshold of the reconstruction time resolution is obtained in the following manner:

[0086] Obtain injection parameters of the perfusion contrast agent and / or different imaging phases, where the injection parameters include at least one of the concentration, injection volume, and injection speed of the perfusion contrast agent;

[0087] Determine a preset threshold of the reconstruction time resolution that matches the injection parameters and / or the different imaging phases.

[0088] Optionally, in an embodiment of the present application, the preset threshold of the reconstruction time resolution is obtained in the following manner:

[0089] According to the accuracy requirement of the perfusion parameters, set a preset threshold of the reconstruction time resolution that matches the accuracy requirement.

[0090] Optionally, in an embodiment of the present application, after completing the reconstruction of the projection data within the entire reconstruction angle range, the method further includes:

[0091] Display the reconstruction result of the projection data within the reconstruction angle range.

[0092] Optionally, in an embodiment of the present application, the scanning angle range includes the maximum scanning range of the scanning device.

[0093] Embodiments of the present application also provide a processing device for implementing the functions of the above-mentioned perfusion scanning and reconstruction device 105. As Figure 6 shown, the processing device 600 includes: a processor and a memory for storing processor-executable instructions; wherein, when the processor is configured to execute the instructions, the above-mentioned device is implemented. The processing device 600 includes a memory 601, a processor 603, a bus 605, and a communication interface 607. The memory 601, the processor 603, and the communication interface 607 communicate with each other through the bus 605. The bus 605 can be a peripheral component interconnect (PCI) bus or an extended industry standard architecture (EISA) bus, etc. The bus can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Figure 6 only a thick line is used to represent it in the figure, but it does not mean that there is only one bus or one type of bus. The communication interface 607 is used for external communication.

[0094] Among them, the processor 603 may be a central processing unit (CPU). The memory 601 may include volatile memory, such as random access memory (RAM). The memory 601 may also include non-volatile memory, such as read-only memory (ROM), flash memory, HDD or SSD.

[0095] The executable code is stored in the memory 601, and the processor 603 executes the executable code to execute the foregoing test scenario construction method.

[0096] Embodiments of the present application provide a scanning device, which is characterized by including a scanning frame, a detector, and the processing device 600, wherein,

[0097] The detector is installed on the scanning frame and is used to scan a scanning object;

[0098] The scanning frame is used to drive the detector to rotate.

[0099] In the embodiments of the present application, the scanning frame may include a C-arm, and the scanning device may include a digital subtraction angiography (DSA) machine. Of course, in other embodiments, the scanning device may include any perfusion scanning device capable of rotating around a scanning object for scanning, which is not limited herein.

[0100] Embodiments of the present application provide a computer-readable storage medium, on which computer program instructions are stored, and when the computer program instructions are executed by a processor, the above method is implemented.

[0101] Embodiments of the present application provide a computer program product, including computer-readable code, or a non-volatile computer-readable storage medium carrying computer-readable code. When the computer-readable code runs in a processor of an electronic device, the processor in the electronic device executes the above method.

[0102] In some embodiments, the disclosed method may be implemented as computer program instructions encoded in a computer-readable storage medium in a machine-readable format or encoded in other non-transitory media or articles. Figure 7A conceptual partial view of an example computer program product arranged in accordance with at least some of the embodiments presented herein is schematically shown. The example computer program product includes a computer program for executing a computer process on a computing device. In one embodiment, the example computer program product 700 is provided using a signal-bearing medium 701. The signal-bearing medium 701 may include one or more program instructions 702 that, when run by one or more processors, may provide the functions or portions of the functions described above for Figure 2 described. Additionally, Figure 7 the program instructions 702 in

[0103] In some examples, the signal-bearing medium 701 may include a computer-readable medium 703, such as but not limited to, a hard disk drive, a compact disk (CD), a digital video disk (DVD), a digital tape, a memory, a read-only memory (ROM), or a random access memory (RAM), etc. In some implementations, the signal-bearing medium 701 may include a computer-recordable medium 704, such as but not limited to a memory, a read / write (R / W) CD, an R / W DVD, etc. In some implementations, the signal-bearing medium 701 may include a communication medium 705, such as but not limited to, a digital and / or analog communication medium (e.g., a fiber optic cable, a waveguide, a wired communication link, a wireless communication link, etc.). Thus, for example, the signal-bearing medium 701 may be conveyed by a wireless form of the communication medium 705 (e.g., a wireless communication medium compliant with the IEEE 802.11 standard or other transmission protocols). The one or more program instructions 702 may be, for example, computer-executable instructions or logic implementation instructions. In some examples, a computing device, such as the computing device described for Figure 2 described, may be configured to provide various operations, functions, or actions in response to the program instructions 702 communicated to the computing device via one or more of the computer-readable medium 703, the computer-recordable medium 704, and / or the communication medium 705. It should be understood that the arrangements described herein are for illustrative purposes only. Thus, those skilled in the art will understand that other arrangements and other elements (e.g., machines, interfaces, functions, orders, and groups of functions, etc.) can be used instead, and some elements may be omitted altogether depending on the desired results. Additionally, many of the elements described can be implemented as discrete or distributed components, or as functional entities combined with other components in any suitable combination and location.

[0104] The flowcharts and block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of apparatus, systems, and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagram may represent a module, a segment of a program, or a portion of an instruction, which contains one or more executable instructions for implementing a specified logical function. In some alternative implementations, the functions noted in the blocks may occur in a different order than that noted in the accompanying drawings. For example, two consecutive blocks may in fact be executed substantially in parallel, or they may sometimes be executed in the reverse order, depending on the functions involved.

[0105] It should also be noted that each block in the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, can be implemented by hardware (such as circuits or ASICs (Application Specific Integrated Circuits)) that perform the corresponding functions or actions, or can be implemented by a combination of hardware and software, such as firmware, etc.

[0106] Although the present invention has been described in connection with various embodiments, it will be understood by those skilled in the art that other variations of the disclosed embodiments can be understood and achieved by viewing the drawings, the disclosure, and the appended claims during the practice of the claimed invention. A single processor or other unit may implement several functions recited in the claims. Certain measures are recited in mutually different dependent claims, but this does not mean that these measures cannot be combined to produce good results.

[0107] The embodiments of the present application have been described above. The above description is exemplary and not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The choice of terms used herein is intended to best explain the principles of the embodiments, the practical application, or the improvement of technologies in the market, or to enable other ordinary skilled persons in the art to understand the embodiments disclosed herein.

Claims

1. A perfusion scanning and reconstruction method, characterized in that, comprising: selecting a plurality of reconstruction angle ranges from within a scanning angle range according to a preset threshold of reconstruction time resolution; scanning a scanning object according to the scanning angle range, and respectively performing real-time reconstruction on the projection data obtained by scanning starting from the starting angles of the plurality of reconstruction angle ranges until the reconstruction of the projection data within the entire reconstruction angle range is completed.

2. The method according to claim 1, characterized in that, the step of selecting a plurality of reconstruction angle ranges from within a scanning angle range according to a preset threshold of reconstruction time resolution comprises: obtaining a preset threshold of reconstruction time resolution and the rotation speed of a scanning device; determining an upper limit value of a reconstruction angle step according to the preset threshold and the rotation speed; selecting a plurality of reconstruction angle ranges from within a scanning angle range, and setting the step between adjacent two reconstruction angle ranges to be not greater than the upper limit value of the reconstruction angle step.

3. The method according to claim 1, characterized in that, the preset threshold of reconstruction time resolution is obtained in the following manner: obtaining injection parameters of a perfusion contrast agent and / or different imaging stages, where the injection parameters include at least one of the concentration, injection volume, and injection speed of the perfusion contrast agent; determining a preset threshold of reconstruction time resolution that matches the injection parameters and / or the different imaging stages.

4. The method according to claim 1, characterized in that, the preset threshold of reconstruction time resolution is obtained in the following manner: setting a preset threshold of reconstruction time resolution that matches the accuracy requirement according to the accuracy requirement of perfusion parameters.

5. The method according to claim 1, characterized in that, after the reconstruction of the projection data within the entire reconstruction angle range is completed, the method further comprises: displaying the reconstruction result of the projection data within the reconstruction angle range.

6. The method according to any one of claims 1-5, characterized in that, the scanning angle range includes the maximum scanning range of a scanning device.

7. A perfusion scanning and reconstruction device, characterized in that, comprising: a reconstruction angle selection module, configured to select a plurality of reconstruction angle ranges from within a scanning angle range according to a preset threshold of reconstruction time resolution; a scanning and reconstruction module, configured to scan a scanning object according to the scanning angle range, and respectively perform real-time reconstruction on the projection data obtained by scanning at the starting angles of the plurality of reconstruction angle ranges until the reconstruction of the projection data within the entire reconstruction angle range is completed.

8. A processing device, comprising a memory and a processor, characterized in that, a computer program is stored in the memory, and the processor is configured to run the computer program to execute the perfusion scanning and reconstruction method according to any one of claims 1 to 6.

9. A scanning device, characterized in that, comprising a gantry, a detector, and the processing device according to claim 8, wherein, the detector is installed on the gantry and is configured to scan a scanning object; the gantry is configured to drive the detector to rotate.

10. A computer storage medium, characterized in that, A computer program is stored in the storage medium, wherein the computer program is configured to execute the perfusion scanning and reconstruction method according to any one of claims 1 to 6 when running.

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