Multifunctional automatic post-processing device based on biological fluid sample filtration

Abstract

The present invention is a multifunctional automatic post-processing device based on biological fluid sample filtration, a storage component is arranged in a sliding component, the sliding component is also slidably connected to a functional component, the functional component adjusts its relative position with the storage component by sliding, the screw motor provides horizontal movement for the sliding platform, the guide rod cylinder provides axial telescopic movement for the vacuum suction cup and the pressure column, the inkjet printer nozzle provides information printing by horizontal movement, the feeding cylinder is in contact with and connected to the inkjet pad paper, and provides floating support for the inkjet pad paper, and the filter support in the diaphragm collection tank is stepped down by a piston. The present invention solves the problems of low processing efficiency, easy sample loss, easy residue and cross contamination, inability to achieve automatic synchronous online interaction and transfer of information, and uncontrollable and substandard sample production indicators during the experiment.

Description

Technical Field

[0001] The present invention relates to a multifunctional automatic post-processing device based on biological fluid sample filtration, wherein the biological fluid specifically includes urine, saliva, human milk, blood and other liquids. Background Art

[0002] Hospitals perform a large number of biofluid tests each year, but these samples cannot be stored long-term under normal conditions, leading to the disposal of a vast amount of valuable samples. Currently, biofluid storage is costly, technically challenging, and requires significant space, making it difficult to establish a biofluid sample library. A method for storing biofluid samples and establishing a long-term, effective biofluid sample library would allow for timely extraction and analysis. This would be crucial for disease screening and prevention, accurate diagnosis and prognosis of individual illnesses, and improving public health. Currently, more researchers are exploring the use of manual filtration of biofluids through a membrane filter to retain proteins on the membrane. The membrane is then dried to create a dry membrane biofluid sample, which is then vacuum-sealed for long-term, reliable storage for subsequent analysis. However, this manual filtration method, using a fixed membrane device, can lead to cross-contamination when removing the adsorption filter membrane. Furthermore, large sample volumes can lead to confusion and asymmetry between sample information and actual recorded information. Summary of the Invention

[0003] The present invention provides a multifunctional automatic post-processing device based on biological fluid sample filtration, which solves the problems of low processing efficiency, easy sample loss, easy residue and cross contamination, the inability to achieve automatic synchronous online interaction and transfer of information, and the problem of uncontrollable and substandard sample preparation indicators during the experiment.

[0004] In order to achieve the above object, the technical solution adopted by the present invention is:

[0005] A multifunctional automatic post-processing device based on biological fluid sample filtration, characterized in that: a storage component is provided in a sliding component, the sliding component is also slidably connected to a functional component, and the functional component adjusts its relative position with the storage component by sliding;

[0006] The sliding assembly includes a screw motor, a linear guide slider component and a sliding platform, the linear guide slider component is slidably connected to the sliding platform, and the sliding platform is also transmission-connected to the screw motor, and the screw motor provides horizontal movement of the sliding platform;

[0007] The functional components include a container base, a guide rod cylinder and an inkjet printer head. The container base is fixedly connected to the sliding platform. The guide rod cylinder is fixed to the container base through a cylinder mounting plate. The guide rod cylinder allows the vacuum suction cup and the pressure column to move axially. The inkjet printer head is fixed to the container base through a nozzle fixing seat. The inkjet printer head prints information by moving horizontally.

[0008] The storage component includes a feeding cylinder and a diaphragm collecting tank. The feeding cylinder is in contact with the inkjet pad paper through a sliding block to provide floating support for the inkjet pad paper. The filter support in the diaphragm collecting tank is stepped and slid down through a piston.

[0009] The multifunctional automatic post-processing device based on biological fluid sample filtration, wherein: the sliding assembly also includes a bottom plate, a vertical plate and a top plate, the bottom plate is fixedly connected to the top plate through a pair of vertical plates, the screw motor is arranged on the vertical plate, the linear guide slider component is arranged on the top plate, and the image recognition camera is arranged on the top plate.

[0010] The multifunctional automatic post-processing device based on biological fluid sample filtration, wherein: the base plate can be fixed or removed by rotating a pair of butterfly bolts, and fulcrum step screws are arranged on both sides of the base plate, wherein the fulcrum step screw on one side is a rotating shaft, and the fulcrum step screw on the other side is for rotation angle positioning.

[0011] The multifunctional automatic post-processing device based on biological fluid sample filtration, wherein: the guide rod cylinder is transmission-connected to the pressure column, the vacuum suction cup is arranged inside the bottom end of the pressure column, the vacuum suction cup is flush with the end surface of the pressure column, and the vacuum suction cup is connected to the vacuum pump.

[0012] The multifunctional automatic post-processing device based on biological fluid sample filtration, wherein: the storage component further comprises a dual-chamber base, the dual-chamber base is fixedly supported by side support plates, and the dual-chamber base is divided into a small chamber and a large chamber;

[0013] The feeding cylinder is arranged below the small cavity, the inkjet pad paper is arranged in the small cavity, a pluggable baffle is arranged on the top of the inkjet pad paper, the top of the baffle is in contact with a fixed baffle, and the fixed baffle is fixed to the top surface of the double-cavity base;

[0014] The diaphragm collecting tank is arranged in the large cavity, and the inner wall of the diaphragm collecting tank is in contact with and connected to the piston via an O-ring.

[0015] The beneficial effects of the present invention are as follows: solving the problems of low processing efficiency, easy sample loss, easy residue and cross contamination, inability to achieve automatic synchronous online interaction and transfer of information, and uncontrollable and substandard sample preparation indicators during the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a structural diagram of a multifunctional automatic post-processing device based on biological fluid sample filtration.

[0017] Figure 2 This is a diagram of the sliding component.

[0018] Figure 3 A diagram of the functional components.

[0019] Figure 4 Create a diagram for storage components.

[0020] Figure 5 This is a schematic diagram of the paper pad coding process of this device.

[0021] Figure 6 This is a schematic diagram of the paper adsorption process of this device.

[0022] Figure 7 This is a schematic diagram of the device for sample membrane separation, storage and collection.

[0023] Explanation of the reference numerals: 1-diaphragm adapter; 2-image recognition camera; 100-sliding assembly; 101-base plate; 102-butterfly bolt; 103-fulcrum step screw; 104-vertical plate; 105-screw motor; 106-top plate; 107-linear guide slider component; 108-sliding platform; 200-functional component; 201-assembly base plate; 202-vacuum suction cup; 203-pressure column; 204-cylinder mounting plate; 205-guide rod cylinder; 206-nozzle fixing seat; 207-inkjet printer nozzle; 300-storage assembly; 301-dual-cavity base; 302-feeding cylinder; 303-side support plate; 304-sliding block; 305-inkjet printing pad paper; 306-block; 307-fixed block; 308-diaphragm collecting tank; 309-piston; 310-O-ring. DETAILED DESCRIPTION

[0024] like Figure 1 As shown, the multifunctional automatic post-processing device based on biological fluid sample filtration provided by the present invention includes a sliding component 100, a functional component 200 and a storage component 300;

[0025] The storage component 300 is disposed in the sliding component 100 . The sliding component 100 is also slidably connected to the functional component 200 . The functional component 200 adjusts its relative position with the storage component 300 by sliding.

[0026] like Figure 2 As shown, the sliding assembly 100 includes a bottom plate 101, a vertical plate 104, a screw motor 105, a top plate 106, a linear guide slider component 107 and a sliding platform 108;

[0027] The bottom plate 101 is fixedly connected to the top plate 106 through a pair of vertical plates 104, the vertical plates 104 are provided with the screw motor 105, the top plate 106 is provided with the linear guide slider component 107, the linear guide slider component 107 is slidably connected to the sliding platform 108, the screw motor 105 is transmission-connected to the sliding platform 108 through a screw nut, the screw motor 10 utilizes forward rotation or reverse rotation to move the sliding platform 108 horizontally, and the top plate 106 is provided with an image recognition camera 2;

[0028] A pair of butterfly bolts 102 are provided through the base plate 101. The base plate 101 can be quickly fixed or removed by rotating the butterfly bolts 102. A fulcrum step screw 103 is arranged on both sides of the base plate 101. The butterfly bolts 102 can be quickly removed manually. The sliding assembly can rotate along the fulcrum step screw 103 on one side as a rotating axis, and the fulcrum step screw 103 on the other side is used for positioning when rotating and resetting.

[0029] like Figure 3 As shown, the functional component 200 includes a container base 201, a vacuum suction cup 202, a pressure column 203, a guide rod cylinder 205 and an inkjet printer nozzle 207;

[0030] The collecting base plate 201 is fixedly connected to the sliding platform 108, and the guide rod cylinder 205 is fixed to the collecting base plate 201 through the cylinder mounting plate 204. The guide rod cylinder 205 is transmission-connected to the pressure column 203, and the bottom end of the pressure column 203 is embedded with the vacuum suction cup 202. The guide rod cylinder 205 can make the vacuum suction cup 202 and the pressure column 203 move axially together, and the vacuum suction cup 202 is flush with the end face of the pressure column 203. The vacuum suction cup 202 is connected to the vacuum pump, and the vacuum suction cup 202 uses vacuum to absorb the inkjet pad 305. The pressure column 203 can separate the diaphragm adapter 1 through the thrust of the guide rod cylinder 205. The separated filter screen holder is placed in the diaphragm collection tank 308. The inkjet printer nozzle 207 is fixed to the collecting base plate 201 through the nozzle fixing seat 206. By utilizing horizontal movement and receiving the coding instructions from the upstream controller, dynamic printing of sample diaphragm information is achieved.

[0031] like Figure 4 As shown, the storage assembly 300 includes a dual-chamber base 301, a feed cylinder 302 and a diaphragm collection tank 308;

[0032] The dual-cavity base 301 is fixedly supported by the side support plate 303 , and the dual-cavity base 301 is separated into a small cavity 311 and a large cavity 312 ;

[0033] The feeding cylinder 302 is arranged below the small cavity 311, and the inkjet paper pad 305 is arranged in the small cavity 311. The feeding cylinder 302 is in contact with the inkjet paper pad 305 through a sliding block 304 to provide floating support for the inkjet paper pad 305. A pluggable baffle 306 is arranged on the top of the inkjet paper pad 305. The top of the baffle 306 is in contact with a fixed baffle 307, and the fixed baffle 307 is fixed to the top surface of the double-cavity base 301;

[0034] The diaphragm collecting tank 308 is set in the large cavity 312. The inner wall of the diaphragm collecting tank 308 is in contact with the piston 309 through the O-ring 310, and generates appropriate friction. The separated filter holders in the diaphragm collecting tank 308 are pushed down step by step by the piston 309. The piston 309 is pushed down step by step by accumulating, so that the collected filter holders are regularly and neatly arranged in the diaphragm collecting tank 308.

[0035] Combine Figure 1 、 Figure 5 Explain the pad paper coding process. Figure 1 The initial state of the device is to start the screw motor 105 and rotate it in the forward direction, driving the sliding platform 108 to move toward the side close to the screw motor 105. When the sliding platform 108 finishes moving, the device is as follows: Figure 5 As shown, the inkjet printer nozzle 207 starts to perform the coding action at a preset point during the movement, and prints the content to be printed on the coding pad paper 305. The coding action is completed before the sliding platform 108 finishes moving. This coding process is a dynamic coding process.

[0036] Combine Figure 1 、 Figure 5 、 Figure 6 The paper picking process is described below. After the inkjet printing is completed, the status of the device is as follows: Figure 5 As shown, the screw motor 105 is started and rotated in the reverse direction, driving the sliding platform 108 to move away from the screw motor 105. When the sliding platform 108 finishes moving, the device is as shown in FIG. Figure 1 As shown, the guide rod cylinder 205 is started to move forward, driving the vacuum suction cup 202 to move downward and contact the inkjet printing pad 305, and at the same time, the vacuum pump is turned on to make the vacuum suction cup 202 have negative pressure and absorb the inkjet printing pad 305. At this time, the device is as shown in FIG. Figure 6 As shown, the guide rod cylinder 205 moves in the opposite direction, and the inkjet printing pad 305 is taken out by the vacuum suction cup 202, and the process of adsorption and paper removal is completed. Figure 1 shown.

[0037] Combine Figure 1 、 Figure 5 、 Figure 7 The separation of the membrane adapter 1 and the collection of the filter holder are described. After the adsorption and paper removal process is completed, the status of the device is as follows: Figure 1 As shown, the screw motor 105 is started and rotated in the forward direction, driving the sliding platform 108 to move toward the side close to the screw motor 105. When the movement is completed, the state of the device is as follows: Figure 5 As shown, the guide rod cylinder 205 is started to move forward, driving the vacuum suction cup 202 and the pressure column 203 to move simultaneously. The pressure column 203 uses the thrust of the guide rod cylinder 205 to separate the diaphragm adapter 1. The filter holder is placed on the piston 309 in the diaphragm collection tank 308. The piston 309 steps down and at the same time, the vacuum pump is turned off to separate the coding pad 305 from the vacuum suction cup 202, leaving the coding pad 305 above the sample diaphragm in the filter holder. At this time, the device is as shown in FIG. Figure 7 As shown, the guide cylinder 205 moves in the reverse direction, and the screw motor 105 rotates in the reverse direction, driving the sliding platform 108 to move away from the screw motor 105 and return to the initial state of the device. At this time, the device stops at the position shown in FIG. Figure 1 shown.

[0038] During the separation process of the diaphragm adapter 1, the device always maintains the coding pad paper 305 corresponding to the diaphragm in direct contact with the sample diaphragm, so that no part of the device is in direct contact with the sample diaphragm, fundamentally eliminating the risk of cross contamination. When the device is reset, the image recognition camera 2 is set on the top plate 106, which will verify and compare the content of the coding pad paper 305 remaining above the sample diaphragm after each separation, to ensure that the sample information content is complete, accurate and clear, and convenient for long-term storage.

[0039] Advantages of the present invention:

[0040] It solves the problems of low processing efficiency, easy sample loss, easy residue and cross contamination, the inability to achieve automatic synchronization of online interaction and transfer of information, and the problem of uncontrollable and substandard sample production indicators during the experiment.

[0041] The above description is only illustrative of the present invention and not restrictive. Those skilled in the art will understand that many modifications, changes or equivalents may be made without departing from the spirit and scope defined by the claims, and all of them will fall within the scope of protection of the present invention.

Claims

1. A multifunctional automatic post-processing device based on biological fluid sample filtration, characterized by: A storage component (300) is provided in the sliding component (100), and the sliding component (100) is also slidably connected to the functional component (200), and the functional component (200) adjusts its relative position with the storage component (300) by sliding. The sliding assembly (100) includes a screw motor (105), a linear guide slider component (107) and a sliding platform (108); the linear guide slider component (107) is slidably connected to the sliding platform (108); the sliding platform (108) is also transmission-connected to the screw motor (105); the screw motor (105) enables the sliding platform (108) to move horizontally; The functional component (200) includes a container base (201), a guide rod cylinder (205) and an inkjet printer nozzle (207); the container base (201) is fixedly connected to the sliding platform (108); the guide rod cylinder (205) is fixed to the container base (201) via a cylinder mounting plate (204); the guide rod cylinder (205) allows the vacuum suction cup (202) and the pressure column (203) to move axially, and the inkjet printer nozzle (207) is fixed to the container base (201) via a nozzle fixing seat (206); and the inkjet printer nozzle (207) prints information by moving horizontally; The storage assembly (300) includes a feeding cylinder (302) and a diaphragm collecting tank (308). The feeding cylinder (302) is in contact with the inkjet printing pad (305) via a sliding block (304) to provide floating support for the inkjet printing pad (305). The diaphragm collecting tank (308) allows the filter support to step down via a piston (309).

2. The multifunctional automatic post-processing device based on biological fluid sample filtration according to claim 1, characterized in that: The sliding assembly (100) further comprises a bottom plate (101), a vertical plate (104) and a top plate (106); the bottom plate (101) is fixedly connected to the top plate (106) via a pair of vertical plates (104); the screw motor (105) is arranged on the vertical plate (104); the linear guide rail slider component (107) is arranged on the top plate (106); and an image recognition camera (2) is arranged on the top plate (106).

3. The multifunctional automatic post-processing device based on biological fluid sample filtration according to claim 2, characterized in that: The base plate (101) can be fixed or disassembled by rotating a pair of butterfly bolts (102), and fulcrum step screws (103) are arranged on both sides of the base plate (101), wherein the fulcrum step screw (103) on one side is a rotating shaft, and the fulcrum step screw (103) on the other side is for rotation angle positioning.

4. The multifunctional automatic post-processing device based on biological fluid sample filtration according to claim 1, characterized in that: The guide rod cylinder (205) is in transmission connection with the pressure column (203); the vacuum suction cup (202) is arranged inside the bottom end of the pressure column (203); the vacuum suction cup (202) is flush with the end surface of the pressure column (203); and the vacuum suction cup (202) is connected to a vacuum pump.

5. The multifunctional automatic post-processing device based on biological fluid sample filtration according to claim 1, characterized in that: The storage assembly (300) further comprises a dual-cavity base (301), wherein the dual-cavity base (301) is fixedly supported by a side support plate (303), and a small cavity (311) and a large cavity (312) are separately provided in the dual-cavity base (301); The feeding cylinder (302) is arranged below the small cavity (311), the coding pad paper (305) is arranged in the small cavity (311), a pluggable baffle (306) is arranged at the top of the coding pad paper (305), the top of the baffle (306) is in contact with a fixed baffle (307), and the fixed baffle (307) is fixed to the top surface of the double-cavity base (301); The diaphragm collecting tank (308) is arranged in the large cavity (312), and the inner wall of the diaphragm collecting tank (308) is in contact with and connected to the piston (309) via an O-ring (310).

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