Aquilaria bath liquid with anti-bacterial and anti-inflammatory functions

Abstract

The application provides a luffa bath liquid with antibacterial and anti-inflammatory functions, which comprises the following components by weight: 10-18 parts of a ketone compound extract as a first component, 22-35 parts of a lignan compound extract as a second component, 2-5 parts of a triterpene compound as a third component, and 20-30 parts of butyl avocadoate as a fourth component. The luffa bath liquid has an effect of inhibiting the respiratory burst of neutrophils to a certain extent, and can prevent the occurrence of allergic diseases and some cardiovascular and cerebrovascular diseases. The effect is obtained by combining the first component, the second component and the third component.

Description

Technical Field

[0001] The invention belongs to the field of daily cleaning products, and in particular relates to an agarwood bath liquid with antibacterial and anti-inflammatory functions. Background Art

[0002] Agarwood was first mentioned in the Liang Dynasty's "Ming Yi Bie Lu" by Tao Hongjing, where it was listed as a top-grade medicinal herb. Its pungent and slightly warm properties promote qi circulation and relieve pain, warm the middle and stop vomiting, and promote qi circulation and relieve asthma. It is primarily used to treat chest and abdominal distension and pain, stomach cold, vomiting, and hiccups, as well as kidney deficiency, qi reversal, and shortness of breath. Agarwood is a key ingredient in over 160 Chinese patent medicines and herbal formulas, including Chenxiangqu (Agarwood Qu), Chenxiang Huaqi Pills, Chenxiang Huazhi Pills, Bawei Chenxiang Powder, and Chenxiang Yangwei Pills. It enjoys widespread use. Beyond its medicinal uses, agarwood is also a renowned natural spice.

[0003] Research results indicate that agarwood volatile oil can significantly reduce the oxidative damage caused by H₂O₂ to cells within a certain range, demonstrating antioxidant activity. β-Caryophyllene in agarwood has inhibitory activity against the growth of six human pathogens and two fungi (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Rhizopus). These findings suggest that agarwood has promising application prospects. Terpenoids in agarwood exhibit significant in vitro antidepressant activity and significantly inhibit 5-HT reuptake in rat brain synapses.

[0004] Existing agarwood is used in cleaning products such as cleaning hair or skin. It is applied evenly and then immediately rinsed with water, which does not truly bring out the functions and effects of agarwood. Therefore, researchers put agarwood into medicine bags and use them in the bath process. However, the proportion of functional components released by soaking agarwood in water is very low, which not only lacks obvious effects but also causes waste of agarwood materials. Summary of the Invention

[0005] The purpose of the present invention is to provide an agarwood bath liquid with antibacterial and anti-inflammatory functions to address the shortcomings of the prior art bath liquid that only cleanses but does not provide maintenance and protection for the skin and the low release rate of functional ingredients in the bath medicine bag.

[0006] To achieve the above objectives, the specific plan is as follows:

[0007] Disclosed is an agarwood bath liquid with antibacterial and anti-inflammatory functions. The components include: a first component of 10-18 parts by weight of a ketone compound extract, a second component of 22-35 parts by weight of a lignan compound extract, a third component of 2-5 parts by weight of a triterpenoid compound, and a fourth component of 20-30 parts by weight of butyl avocado oleate.

[0008] In the present invention, the first component of the ketone compound extract comprises 1-3 parts by weight of flavonoid compounds and 9-15 parts by weight of a mixed extract of benzophenone compounds and xanthones.

[0009] The present invention is further preferred, wherein the extraction process of the flavonoid compound is as follows: 1) washing and drying the trunk of Aquilaria sinensis; 2) crushing the trunk to 60-100 mesh to obtain Aquilaria sinensis trunk powder; 3) adding an entrainer, ethyl acetate, and mixing uniformly, wherein the weight ratio of the ethyl acetate to the Aquilaria sinensis trunk powder is 1:20-30; 4) freeze drying: freeze drying the Aquilaria sinensis trunk powder with the entrainer at -30 to -20°C for 2-3h; 5) supercritical extraction: loading the freeze-dried powder into an extraction kettle for CO2 supercritical extraction, wherein the extraction conditions are: extraction pressure of 18-20MPa, extraction temperature of 30-45°C, extraction time of 1-2h, separation kettle temperature of 25-36°C, CO2 flow rate of 30-80L / h, and separation kettle pressure of 6-8MPa; 6) separation: after the extraction is completed, the liquid discharged from the separation kettle is the flavonoid compound.

[0010] Further preferably, the present invention comprises the following extraction processes for the benzophenone compound extract and the xanthones extract: 1) washing and drying the aquilaria sinensis leaves; 2) preparing a 3%-8% by volume ethanol aqueous solution; 3) soaking the washed and dried aquilaria sinensis leaves in the ethanol aqueous solution for 20-50 hours, wherein the weight ratio of the aquilaria sinensis leaves to the ethanol aqueous solution is 1:3-6; and 4) distilling, placing the soaking liquid solid and liquid together into a molecular distillation scraped film equipment, the distillation pressure being 60-100 Pa, the scraped film speed being 100-300 r / min, and the distillation temperature being 70-90° C., and the distillate being the benzophenone compound extract and the xanthones extract.

[0011] The present invention is further preferred, and the extraction process of the second component lignan compound extract is: 1) washing, drying and crushing the white agarwood trunk; 2) placing the crushed white agarwood trunk powder into deionized water, and the weight ratio of white agarwood leaves to deionized water is 1:5-7; 3) placing the soaking liquid solid and liquid together into a molecular distillation scraping film equipment, the distillation pressure is 60-80Pa, the scraping film speed is 100-300r / min, the distillation temperature is 85-93°C, and the distillate is the lignan compound extract.

[0012] It is further preferred in the present invention that the triterpene compound of the third component comprises a mixture of a tetracyclic triterpene compound and a pentacyclic triterpene compound.

[0013] The present invention is further preferred, and the extraction process of the mixture of tetracyclic triterpenoid compounds and pentacyclic triterpenoid compounds is as follows: 1) washing and drying white agarwood leaves; 2) crushing to 60-100 mesh; 3) adding entrainer ethanol and mixing evenly, wherein the weight ratio of ethanol to white agarwood leaf powder is 2:3-5; 4) freeze drying: freezing the white agarwood trunk powder with entrainer ethanol at -30 to -20°C for 2-3h; 5) supercritical extraction: charging the freeze-dried powder into an extraction kettle for CO2 supercritical extraction, wherein the extraction conditions are: extraction pressure 25-28MPa, extraction temperature 50-60°C, extraction time 1-2h, separation kettle temperature 30-35°C, CO2 flow rate 60-80L / h; separation kettle pressure 10-12MPa; 6) separation: after the extraction is completed, the liquid discharged from the separation kettle is a mixture of tetracyclic triterpenoid compounds and pentacyclic triterpenoid compounds.

[0014] The present invention is further preferred. The preparation method of the agarwood bath liquid with antibacterial and anti-inflammatory functions is as follows: 1) mixing the first component ketone compound extract and the third component triterpenoid compound, 2) slowly heating the mixture of the first component ketone compound extract and the third component triterpenoid compound to 50-65°C at a temperature of 0.1-0.2°C / min, stirring evenly, and maintaining the temperature for 12-20 minutes, 3) adding an auxiliary agent and stirring evenly, 4) adding the second component lignan compound extract and the fourth component butyl avocado oil, stirring evenly and cooling to 10-15°C to obtain the agarwood bath liquid with antibacterial and anti-inflammatory functions.

[0015] It is further preferred in the present invention that the auxiliary agent includes a surfactant and a preservative.

[0016] The surfactant is fatty acid glyceride, and the preservative is sodium citrate.

[0017] The advantages and principles of the present invention are as follows:

[0018] 1. The agarwood bath liquid of the present invention has the effect of inhibiting the respiratory burst of neutrophils to a certain extent, which can prevent the occurrence of allergies and some cardiovascular and cerebrovascular diseases. During the experiment, it was found that this effect can only be achieved by combining the first component, the second component and the third component.

[0019] 2. The agarwood bath liquid of the present invention has the effects of antibacterial, anti-inflammatory, anti-allergic and regulating tissue repair and regeneration. This mechanism of action is related to triterpenoids and flavonoids.

[0020] 3. After use, the surfactant in the agarwood bath liquid of the present invention is mild to the human body and has good biodegradability. It is suitable for cleaning sensitive and allergic skin and is environmentally friendly and pollution-free.

[0021] 4. The agarwood bath liquid obtained by the present invention is not only easy to rinse from the skin with water, but also cleans moderately and has a certain antibacterial ability. After use, it gives people a refreshing and non-greasy feeling, allowing the skin to be cleaned while also obtaining sufficient moisturizing feeling, fully meeting modern people's pursuit and expectation of quality life. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is the process flow chart for the extraction of flavonoids. DETAILED DESCRIPTION

[0023] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions of the invention. Obviously, the embodiments described are only some of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0024] Extraction of flavonoids: refer to the attached Figure 1 :1) wash and dry the trunk of Aquilaria sinensis; 2) grind the trunk to 60-100 mesh to obtain Aquilaria sinensis trunk powder; 3) add ethyl acetate as an entrainer and mix evenly, wherein the weight ratio of ethyl acetate to the Aquilaria sinensis trunk powder is 1:20-30; 4) freeze drying: freeze drying the Aquilaria sinensis trunk powder with the entrainer at -30 to -20°C for 2-3 hours; 5) supercritical extraction: pack the freeze-dried powder into an extraction kettle and perform CO2 supercritical extraction, wherein the extraction conditions are: extraction pressure 18-20MPa, extraction temperature 30-45°C, extraction time 1-2h, separation kettle temperature 25-36°C, CO2 flow rate 30-80L / h; separation kettle pressure 6-8MPa; 6) separation: after the extraction is complete, the liquid discharged from the separation kettle is flavonoids, and the flavonoid acquisition rate is 4.6% after weighing and calculating.

[0025] The method comprises the following steps of extracting benzophenone compound extracts and xanthones: 1) washing and drying aquilaria sinensis leaves; 2) preparing a 3%-8% by volume ethanol aqueous solution; 3) soaking the washed and dried aquilaria sinensis leaves in the ethanol aqueous solution for 20-50 hours, wherein the weight ratio of the aquilaria sinensis leaves to the ethanol aqueous solution is 1:3-6; and 4) distilling the soaking liquid, wherein the solid and liquid of the soaking liquid are placed together in a molecular distillation scraping film equipment, the distillation pressure is 60-100 Pa, the scraping film speed is 100-300 r / min, and the distillation temperature is 70-90° C., the distillate is the benzophenone compound extract and the xanthones extract, and after weighing and calculating, the weight of the benzophenone compound extract and the xanthones extract is 126% of the weight of the aquilaria sinensis leaves.

[0026] Extracting the second component, a lignan compound extract: 1) washing, drying, and crushing a white agarwood trunk; 2) placing the crushed white agarwood trunk powder into deionized water, wherein the weight ratio of white agarwood leaves to deionized water is 1:5-7; 3) placing the soaking liquid solid and liquid together into a molecular distillation scraping film equipment, with a distillation pressure of 60-80 Pa, a scraping film speed of 100-300 r / min, and a distillation temperature of 85-93°C. The distillate is a lignan compound extract, and after weighing and calculating, the weight of the lignan compound extract is 352% of the raw material white agarwood trunk.

[0027] The invention discloses a mixture of tetracyclic triterpenoid compounds and pentacyclic triterpenoid compounds, comprising the following steps: 1) washing and drying Aquilaria sinensis leaves; 2) crushing the leaves to a size of 60-100 mesh; 3) adding ethanol as an entrainer and mixing the mixture uniformly, wherein the weight ratio of the ethanol to the Aquilaria sinensis leaf powder is 2:3-5; 4) freeze-drying the Aquilaria sinensis trunk powder containing the ethanol as an entrainer is frozen at -30 to -20°C for 2-3 hours; 5) supercritical extraction: placing the freeze-dried powder into an extraction kettle for CO2 supercritical extraction, wherein the extraction conditions are: extraction pressure of 25-28 MPa, extraction temperature of 50-60°C, extraction time of 1-2 hours, separation kettle temperature of 30-35°C, CO2 flow rate of 60-80 L / h, and separation kettle pressure of 10-12 MPa; and 6) separation: after the extraction is completed, the liquid discharged from the separation kettle is a mixture of the tetracyclic triterpenoid compounds and the pentacyclic triterpenoid compounds, and the recovery rate of the mixture of the tetracyclic triterpenoid compounds and the pentacyclic triterpenoid compounds is 6.5% after weighing and calculation.

[0028] Example 1:

[0029] An agarwood bath liquid with antibacterial and anti-inflammatory functions is prepared, specifically comprising the following steps: 1) mixing 10 parts by weight of a first component, a ketone compound extract, and 5 parts by weight of a third component, a triterpenoid compound; 2) slowly heating the mixture of the first component, the ketone compound extract, and the third component, the triterpenoid compound, to 50-65° C. at a temperature of 0.1-0.2° C. / min, stirring evenly, and maintaining the temperature for 12-20 minutes; 3) adding 50 parts by weight of deionized water, 3 parts by weight of fatty acid glycerides, and 1 part by weight of sodium citrate, stirring evenly; 4) adding 28 parts by weight of a second component, a lignan compound extract, and 26 parts by weight of a fourth component, butyl avocadate, stirring evenly, and cooling to 10-15° C. to obtain the agarwood bath liquid with antibacterial and anti-inflammatory functions of Example 1.

[0030] Example 2:

[0031] An agarwood bath liquid with antibacterial and anti-inflammatory functions is prepared, specifically comprising the following steps: 1) mixing 13 parts by weight of a first component, a ketone compound extract, and 3 parts by weight of a third component, a triterpenoid compound; 2) slowly heating the mixture of the first component, the ketone compound extract, and the third component, the triterpenoid compound, to 50-65° C. at a temperature of 0.1-0.2° C. / min, stirring evenly, and maintaining the temperature for 12-20 minutes; 3) adding 56 parts by weight of deionized water, 5 parts by weight of fatty acid glycerides, and 3 parts by weight of sodium citrate, stirring evenly; 4) adding 25 parts by weight of a second component, a lignan compound extract, and 22 parts by weight of a fourth component, butyl avocadate; stirring evenly, and cooling to 10-15° C. to obtain the agarwood bath liquid with antibacterial and anti-inflammatory functions of Example 2.

[0032] Example 3: Prepare an agarwood bath liquid with antibacterial and anti-inflammatory functions, the specific steps are: 1) mix 15 parts by weight of the first component ketone compound extract and 2 parts by weight of the third component triterpenoid compound, 2) slowly heat the mixture of the first component ketone compound extract and the third component triterpenoid compound to 50-65°C at a temperature of 0.1-0.2°C / min, stir evenly, and maintain the temperature for 12-20 minutes, 3) add 60 parts by weight of deionized water and 8 parts by weight of fatty acid glyceride and 2 parts by weight of sodium citrate and stir evenly, 4) add 30 parts by weight of the second component lignan compound extract and 20 parts by weight of the fourth component butyl avocado, stir evenly and cool to 10-15°C to obtain the agarwood bath liquid with antibacterial and anti-inflammatory functions of Example 3.

[0033] Example 4: Prepare an agarwood bath liquid with antibacterial and anti-inflammatory functions, the specific steps are: 1) mix 18 parts by weight of the first component ketone compound extract and 4 parts by weight of the third component triterpenoid compound, 2) slowly heat the mixture of the first component ketone compound extract and the third component triterpenoid compound to 50-65°C at a temperature of 0.1-0.2°C / min, stir evenly, and maintain the temperature for 12-20 minutes, 3) add 58 parts by weight of deionized water and 6 parts by weight of fatty acid glyceride and 1 part by weight of sodium citrate and stir evenly, 4) add 33 parts by weight of the second component lignan compound extract and 30 parts by weight of the fourth component butyl avocado, stir evenly and cool to 10-15°C to obtain the agarwood bath liquid with antibacterial and anti-inflammatory functions of Example 4.

[0034] Example 5: Prepare an agarwood bath liquid, specifically the following steps: 1) slowly heating 13 parts by weight of the first component ketone compound extract to 50-65°C at a temperature of 0.1-0.2°C / min, stirring evenly, and maintaining the temperature for 12-20 minutes; 2) adding 56 parts by weight of deionized water, 5 parts by weight of fatty acid glycerides, and 3 parts by weight of sodium citrate and stirring evenly; 3) adding 25 parts by weight of the second component lignan compound extract and 22 parts by weight of the fourth component butyl avocado oil, stirring evenly, and cooling to 10-15°C to obtain the agarwood bath liquid of Example 5.

[0035] Example 6: Prepare an agarwood bath liquid, the specific steps are: 1) mix 13 parts by weight of the first component ketone compound extract and 3 parts by weight of the third component triterpene compound, 2) slowly heat the mixture of the first component ketone compound extract and the third component triterpene compound at a temperature of 0.1-0.2°C / min to 50-65°C, stir evenly, and maintain the temperature for 12-20 minutes, 3) add 56 parts by weight of deionized water and 5 parts by weight of fatty acid glyceride and 3 parts by weight of sodium citrate and stir evenly, 4) add 22 parts by weight of the fourth component butyl avocado oil, stir evenly and cool to 10-15°C to obtain the agarwood bath liquid of Example 6.

[0036] Example 7: Prepare an agarwood bath liquid, specifically the following steps: 1) slowly heating 13 parts by weight of the first component ketone compound extract to 50-65°C at 0.1-0.2°C / min, stirring evenly, and maintaining the temperature for 12-20 minutes; 2) adding 56 parts by weight of deionized water, 5 parts by weight of fatty acid glycerides, and 3 parts by weight of sodium citrate and stirring evenly; 3) adding 25 parts by weight of the second component lignan compound extract and 22 parts by weight of the fourth component butyl avocado oil, stirring evenly, and cooling to 10-15°C to obtain the agarwood bath liquid of Example 7.

[0037] Example 8: Prepare an agarwood bath liquid, the specific steps are: 1) mix 13 parts by weight of the first component ketone compound extract and 3 parts by weight of the third component triterpene compound, 2) slowly heat the mixture of the first component ketone compound extract and the third component triterpene compound at a temperature of 0.1-0.2°C / min to 50-65°C, stir evenly, and maintain the temperature for 12-20 minutes, 3) add 56 parts by weight of deionized water and 5 parts by weight of fatty acid glyceride and 3 parts by weight of sodium citrate and stir evenly, 4) add 25 parts by weight of the second component lignan compound extract, stir evenly and cool to 10-15°C to obtain the agarwood bath liquid of Example 8.

[0038] Example 9: Prepare an agarwood bath liquid, the specific steps are: 1) mix 13 parts by weight of the first component ketone compound extract, 25 parts by weight of the second component lignan compound extract, 3 parts by weight of the third component triterpenoid compound and 22 parts by weight of the fourth component butyl avocado oil; 2) add 56 parts by weight of deionized water, 5 parts by weight of fatty acid glyceride and 3 parts by weight of sodium citrate, stir evenly, and cool to 10-15°C to obtain the agarwood bath liquid of Example 9.

[0039] The agarwood bath liquid prepared in Example 1-9 was blended with warm water in a ratio of 1:200 to obtain the bath water of Example 1-8.

[0040] Testing Method: Bath waters prepared in Examples 1-9 were tested at a health center. All participants were female and aged 36-53 years. Following the same test method, participants bathed for approximately 15 minutes one hour after a meal (once per week). The participants rated the foaming quality, flushing speed, post-bath skin feel, and mental state of the bath water based on their personal experience.

[0041] After testing, the results are as follows:

[0042]

[0043]

[0044] It can be seen from the above table that Examples 1-8 all produce less foam, are extremely convenient to rinse, and the mind remains clear after bathing without dizziness or the like.

[0045] After bathing with the bath water of Examples 1-4, the skin becomes more moisturized and transparent, and the effect is better.

[0046] After frequently bathing in the bath water of Examples 1-4, people with skin allergies are no longer susceptible to allergies. Based on this, it is speculated that the present invention has the effect of inhibiting the respiratory burst of neutrophils. However, more experimental materials are needed to prove this in principle.

[0047] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A kind of agarwood bath liquid with antibacterial and anti-inflammatory functions, characterized in that the components The invention comprises: a first component comprising 10-18 parts by weight of a ketone compound extract, a second component comprising 22-35 parts by weight of a lignan compound extract, a third component comprising 2-5 parts by weight of a triterpenoid compound, and a fourth component comprising 20-30 parts by weight of butyl avocado ester, wherein the first component comprising the ketone compound extract comprises 1-3 parts by weight of a flavonoid compound and 9-15 parts by weight of a mixed extract of a benzophenone compound and a xanthonoid compound; and the third component comprising the triterpenoid compound comprises a mixture of a tetracyclic triterpenoid compound and a pentacyclic triterpenoid compound. The flavonoids are prepared according to the following extraction process: 1) washing and drying the trunk of Aquilaria sinensis; 2) crushing the trunk to 60-100 mesh to obtain Aquilaria sinensis trunk powder; 3) adding an entrainer, ethyl acetate, and mixing uniformly, wherein the weight ratio of ethyl acetate to the Aquilaria sinensis trunk powder is 1:20-30; 4) freeze-drying: freeze-drying the Aquilaria sinensis trunk powder with the entrainer at -30 to -20°C for 2-3 hours; 5) supercritical extraction: loading the freeze-dried powder into an extraction kettle for CO2 supercritical extraction, wherein the extraction conditions are: extraction pressure of 18-20 MPa, extraction temperature of 30-45°C, extraction time of 1-2 hours, separation kettle temperature of 25-36°C, CO2 flow rate of 30-80 L / h, and separation kettle pressure of 6-8 MPa; 6) separation: after the extraction is completed, the liquid discharged from the separation kettle is the flavonoids; The mixed extract of benzophenone compounds and xanthones is prepared according to the following extraction process: 1) washing and drying white aquilaria sinensis leaves; 2) preparing a 3%-8% by volume ethanol aqueous solution; 3) soaking the washed and dried white aquilaria sinensis leaves in the ethanol aqueous solution for 20-50 hours, with the weight ratio of white aquilaria sinensis leaves to ethanol aqueous solution being 1:3-6; 4) distilling, placing the soaking liquid solid and liquid together into a molecular distillation scraped film equipment, distilling at a pressure of 60-100 Pa, a scraped film speed of 100-300 r / min, and a distillation temperature of 70-90° C., resulting in a distillate of a mixed extract of benzophenone compounds and xanthones; The lignan compound extract is prepared according to the following extraction process: 1) washing, drying, and crushing the trunk of Aquilaria sinensis; 2) placing the crushed Aquilaria sinensis trunk powder into deionized water, wherein the weight ratio of the Aquilaria sinensis trunk powder to the deionized water is 1:5-7; 3) placing the soaking liquid solid and liquid together into a molecular distillation scraped film equipment, with a distillation pressure of 60-80 Pa, a scraped film speed of 100-300 r / min, and a distillation temperature of 85-93° C., and the distillate is the lignan compound extract; The triterpenoid compound is prepared according to the following extraction process: 1) washing and drying white aquilaria sinensis leaves; 2) crushing to 60-100 mesh; 3) adding entrainer ethanol and mixing evenly, wherein the weight ratio of ethanol to white aquilaria sinensis leaf powder is 2:3-5; 4) freeze drying: freezing the white aquilaria sinensis leaf powder with entrainer ethanol at -30 to -20°C for 2-3 hours; 5) supercritical extraction: loading the freeze-dried powder into an extraction kettle for CO2 supercritical extraction, wherein the extraction conditions are: extraction pressure 25-28 MPa, extraction temperature 50-60°C, extraction time 1-2 hours, separation kettle temperature 30-35°C, CO2 flow rate 60-80 L / h; separation kettle pressure 10-12 MPa; 6) separation: after the extraction is completed, the liquid discharged from the separation kettle is the triterpenoid compound; wherein: The preparation method of the agarwood bath liquid is as follows: 1) mixing a first component ketone compound extract and a third component triterpenoid compound; 2) slowly heating the mixture of the first component ketone compound extract and the third component triterpenoid compound to 50-65°C at a temperature of 0.1-0.2°C / min, stirring evenly, and maintaining the temperature for 12-20 minutes; 3) adding a second component lignan compound extract and a fourth component butyl avocado oil, stirring evenly, and cooling to 10-15°C to prepare an agarwood bath liquid with antibacterial and anti-inflammatory functions.

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