Measurement method based on ultrasonic blood flow imaging and ultrasonic blood flow imaging device

Abstract

The present application provides a measurement method based on ultrasonic blood flow imaging and an ultrasonic blood flow imaging device, the method comprising: performing ultrasonic blood flow imaging on vascular tissue at a first target part of a target object to obtain a first blood flow velocity curve, and performing electrocardiogram detection on the target object to obtain a first electrocardiogram signal curve; performing ultrasonic blood flow imaging on vascular tissue at a second target part of the target object to obtain a second blood flow velocity curve, and performing electrocardiogram detection on the target object to obtain a second electrocardiogram signal curve; calculating the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve as the first phase time difference; calculating the phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve as the second phase time difference; calculating the time difference between the first phase time difference and the second phase time difference to obtain the phase time difference between the first blood flow velocity curve and the second blood flow velocity curve.

Description

Technical Field

[0001] The present application relates to the technical field of ultrasonic scanning, and more specifically to a measurement method based on ultrasonic blood flow imaging and an ultrasonic blood flow imaging device. Background Art

[0002] Cardiac activity is electrical activity followed by mechanical contraction, which is an energy-consuming process. There is a physiological delay between electrical and mechanical contraction, but synchronization is a very important link to ensure effective work. After the heart beats, there is a delay in the final transmission of blood flow to different arteries. If there are lesions, such as vascular stenosis, obstacles in the blood vessels (plaques, stents, etc.); arteriosclerosis, poor vascular elasticity; insufficient cardiac power, myocardial ischemia, poor cardiac electrical signal conduction function, etc., hemodynamics will also change. In addition, any problems in the cardiovascular system such as atrial fibrillation, plaques on the arterial walls, etc. can cause synchronization problems. Therefore, it is very important to measure the synchronization of the heart and blood vessels. Summary of the invention

[0003] According to one aspect of the present application, a measurement method based on ultrasonic blood flow imaging is provided, the method comprising: performing ultrasonic blood flow imaging on vascular tissue at a first target site of a target object to obtain a first blood flow velocity curve of the vascular tissue at the first target site within a first time period, performing electrocardiogram detection on the target object to obtain a first electrocardiogram signal curve of the target object within the first time period; performing ultrasonic blood flow imaging on vascular tissue at a second target site of the target object to obtain a second blood flow velocity curve of the vascular tissue at the second target site within a second time period, performing electrocardiogram detection on the target object to obtain a second electrocardiogram signal curve of the target object within the second time period; calculating a phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve as a first phase time difference; calculating a phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve as a second phase time difference; and determining a phase time difference of blood flow from the first target site to the second target site based on the first phase time difference and the second phase time difference.

[0004] According to another aspect of the present application, a measurement method based on ultrasonic blood flow imaging is provided, the method comprising: performing ultrasonic blood flow imaging on vascular tissue of a first target part of a target object to obtain a first blood flow velocity curve of the vascular tissue of the first target part within a first time period, performing electrocardiogram detection on the target object to obtain a first electrocardiogram signal curve of the target object within the first time period; calculating a phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve to obtain a phase time difference between the first blood flow velocity curve of the first target part and the first electrocardiogram signal curve.

[0005] According to another aspect of the present application, a measurement method based on ultrasonic blood flow imaging is provided, the method comprising: performing ultrasonic blood flow imaging on vascular tissue of a first target part of a target object to obtain a first blood flow velocity curve of the vascular tissue of the first target part, performing electrocardiogram detection on the target object to obtain a first electrocardiogram signal curve of the target object; based on the periodic parameters of the target object, corresponding the first blood flow velocity curve and the first electrocardiogram signal curve to the same time axis; calculating the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve on the time axis to obtain the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve of the first target part.

[0006] According to another aspect of the present application, a measurement method based on ultrasonic blood flow imaging is provided, the method comprising: performing ultrasonic blood flow imaging on vascular tissue of a first target part of a target object to obtain an ultrasonic blood flow image of the vascular tissue of the first target part within a first time period, the imaging frame rate of the ultrasonic blood flow imaging being greater than 60 Hz; determining a first position and a second position in the vascular area of ​​the ultrasonic blood flow image; acquiring a first blood flow velocity curve of the first position within the first time period and a second blood flow velocity curve of the second position within the first time period based on an ultrasonic echo signal during the ultrasonic blood flow imaging process; and calculating a first phase time difference between the second blood flow velocity curve and the first blood flow velocity curve to obtain a phase time difference of blood flow from the first position to the second position.

[0007] According to another aspect of the present application, a measurement method based on ultrasonic blood flow imaging is provided, the method comprising: performing ultrasonic blood flow imaging on the vascular tissue of the target object to obtain a first blood flow velocity curve of the blood flow at a first position within a first time period and a second blood flow velocity curve of the blood flow at a second position within the first time period; calculating a first phase time difference between the second blood flow velocity curve and the first blood flow velocity curve to obtain a phase time difference between the second blood flow velocity curve and the first blood flow velocity curve.

[0008] According to another aspect of the present application, an ultrasonic blood flow imaging device is provided, which includes a transmitting circuit, a receiving circuit, an ultrasonic probe and a processor, wherein: the transmitting circuit is used to control the ultrasonic probe to transmit ultrasonic waves to a target part of a target object; the receiving circuit is used to control the ultrasonic probe to receive an echo of the ultrasonic wave and obtain an ultrasonic echo signal from the ultrasonic wave echo; the processor is used to perform ultrasonic blood flow imaging based on the ultrasonic echo signal; and the processor is also used to execute the above-mentioned measurement method based on ultrasonic blood flow imaging.

[0009] According to the measurement method based on ultrasonic blood flow imaging and the ultrasonic blood flow imaging device of the embodiment of the present application, the phase time difference between the blood flow velocity curve and the electrocardiogram signal curve can be obtained, or the phase time difference of the blood flow velocity curves of two parts when the blood flow is transmitted from one target part to another target part can be obtained, or the phase time difference of the blood flow velocity curves between one position and another position in the local blood vessel can be obtained, thereby obtaining the evaluation result of the synchronization index of the cardiovascular system. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] By describing the embodiments of the present application in more detail in conjunction with the accompanying drawings, the above and other purposes, features and advantages of the present application will become more apparent. The accompanying drawings are used to provide a further understanding of the embodiments of the present application and constitute a part of the specification. Together with the embodiments of the present application, they are used to explain the present application and do not constitute a limitation of the present application. In the accompanying drawings, the same reference numerals generally represent the same components or steps.

[0011] Figure 1 A schematic flow chart of a measurement method based on ultrasonic blood flow imaging according to an embodiment of the present application is shown.

[0012] Figure 2 A schematic diagram showing a phase time difference between a blood flow velocity curve and an electrocardiogram signal curve obtained in a measurement method based on ultrasonic blood flow imaging according to an embodiment of the present application.

[0013] Figure 3 A schematic diagram showing a vector blood flow image, a blood flow velocity curve, and an electrocardiogram signal curve in a measurement method based on ultrasonic blood flow imaging according to an embodiment of the present application is shown.

[0014] Figure 4 A schematic flow chart of a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application is shown.

[0015] Figure 5 A schematic diagram showing a first phase time difference obtained in a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application.

[0016] Figure 6 A schematic diagram showing a second phase time difference obtained in a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application.

[0017] Figure 7 A schematic flow chart of a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application is shown.

[0018] Figure 8 A schematic diagram showing a first position and a second position in a blood vessel region of an ultrasonic blood flow image in a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application.

[0019] Fig. 9 A schematic diagram showing a phase time difference between blood flow velocity curves at a first position and a second position in a blood flow obtained in a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application.

[0020] Fig.10 A schematic diagram showing three positions in a blood vessel region of an ultrasonic blood flow image in a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application.

[0021] Fig.11 A schematic diagram showing the phase time difference between the blood flow velocity curves at the first position and the second position in the blood flow, and the phase time difference between the blood flow velocity curves at the second position and the third position in the blood flow obtained in a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application.

[0022] Fig.12 A schematic diagram showing three positions in a cross-sectional blood vessel of an ultrasonic blood flow image in a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application.

[0023] Fig.13 A schematic diagram showing the phase time difference between the blood flow velocity curves at the first position and the second position of the cross-section of the blood flow, and the phase time difference between the blood flow velocity curves at the second position and the third position in a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application.

[0024] Fig.14 A schematic structural block diagram of an ultrasonic blood flow imaging device according to an embodiment of the present application is shown. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the present application more obvious, the example embodiments according to the present application will be described in detail with reference to the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application, and it should be understood that the present application is not limited to the example embodiments described herein. Based on the embodiments of the present application described in the present application, all other embodiments obtained by those skilled in the art without creative work should fall within the scope of protection of the present application.

[0026] First, refer to Figure 1 A measurement method based on ultrasound blood flow imaging according to an embodiment of the present application is described. Figure 1 FIG. 1 is a schematic flow chart of a measurement method 100 based on ultrasound blood flow imaging according to an embodiment of the present application. Figure 1 As shown, the measurement method 100 based on ultrasonic blood flow imaging may include the following steps:

[0027] In step S110, ultrasonic blood flow imaging is performed on the vascular tissue of the first target part of the target object to obtain a first blood flow velocity curve of the vascular tissue of the first target part in a first time period, and electrocardiogram detection is performed on the target object to obtain a first electrocardiogram signal curve of the target object in the first time period.

[0028] In step S120, a phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve is calculated to obtain a phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve of the first target site.

[0029] In an embodiment of the present application, ultrasonic blood flow imaging is combined with an electrocardiogram to obtain the phase time difference between the blood flow velocity curve and the electrocardiogram signal curve, thereby obtaining an evaluation result of the heart and blood vessel synchronization of the target object, providing support for measuring heart and blood vessel synchronization indicators.

[0030] In an embodiment of the present application, the first target part of the target object in step S110 can be any heart chamber (left atrium, right atrium, left ventricle or right ventricle), or any artery (such as the carotid artery, etc.). In an embodiment of the present application, ultrasonic blood flow imaging is performed on the vascular tissue of the first target part of the target object to obtain a blood flow velocity curve of the vascular tissue of the first target part, and the blood flow velocity curve reflects the change of the blood flow velocity in the vascular tissue of the first target part within a certain period of time. Among them, the blood flow velocity in the first blood flow velocity curve may include a vector blood flow velocity or a blood flow velocity measured based on pulse Doppler. Exemplarily, the vector blood flow velocity can be calculated by a speckle tracking method, a transverse wave oscillation method, or a multi-angle deflection transmission and / or receiving method based on the Doppler principle.

[0031] Taking the method of obtaining vector blood flow velocity by multi-angle deflection transmission / reception as an example, an ultrasonic probe is used to transmit an ultrasonic wave to the target blood flow area along a first scanning angle, and an ultrasonic echo of the ultrasonic wave returned from the target blood flow area is received. Based on the ultrasonic echo, a first ultrasonic echo signal along the first scanning angle is obtained, and according to the first ultrasonic echo signal, a first blood flow velocity of a target position (also called a target point) in the target blood flow area is obtained. The first blood flow velocity is actually a projection component (also called a velocity component) of the vector blood flow velocity at the target position at the first scanning angle. Similarly, an ultrasonic probe is used to transmit an ultrasonic wave to the target blood flow area along a second scanning angle, and a second blood flow velocity at the target position can be obtained. The second blood flow velocity is actually a projection component (also called a velocity component) of the vector blood flow velocity at the target position at the second scanning angle. The first blood flow velocity and the second blood flow velocity are angle-synthesized to obtain the actual velocity magnitude and direction, i.e., the vector blood flow velocity.

[0032] As an example, the vector blood flow velocity can also be obtained based on the vector blood flow imaging method of speckle tracking. The vector blood flow velocity calculation of speckle tracking can be realized by using the absolute difference sum. The vector blood flow velocity with higher accuracy can also be obtained based on the plane wave emission and speckle tracking method.

[0033] As an example, the vector blood flow velocity can also be obtained by a vector blood flow imaging method based on the transverse wave oscillation method, wherein the longitudinal velocity is obtained by a traditional calculation method based on the Doppler principle, the transverse velocity is calculated based on the autocorrelation method by generating a transverse oscillating ultrasonic sound field, and then the transverse and longitudinal velocities are combined to obtain the vector blood flow velocity.

[0034] The vector blood flow velocity mentioned above has a velocity magnitude that is the actual velocity magnitude of the blood flow (such as red blood cells in the blood flow), or is closer to the actual velocity magnitude of the blood flow (such as red blood cells in the blood flow); its velocity direction is the actual flow direction of the blood flow (such as red blood cells in the blood flow), or is closer to the actual flow direction of the blood flow (such as red blood cells in the blood flow); the direction of the vector blood flow velocity can be in the range of 0° to 360° in the imaging plane, and its direction can represent the actual flow direction of the blood flow.

[0035] In an embodiment of the present application, in step S110, a blood flow velocity curve of the vascular tissue of the first target part of the target object within a period of time can be obtained, and an electrocardiogram detection is performed on the target object to obtain the electrocardiogram signal curve of the target object within the period of time, and the heart and blood vessel synchronization index can be calculated based on the blood flow velocity curve and the electrocardiogram signal curve. For the sake of clarity of description and to distinguish from the embodiments to be described later, the aforementioned "period of time" is referred to as the "first time period", the aforementioned "blood flow velocity curve" is referred to as the "first blood flow velocity curve", and the aforementioned "electrocardiogram signal curve" is referred to as the "first electrocardiogram signal curve". Therefore, the heart and blood vessel synchronization index of the target object can be calculated based on the first blood flow velocity curve and the first electrocardiogram signal curve. Among them, the first blood flow velocity curve reflects the change of blood flow velocity of the vascular tissue of the first target part of the target object within the first time period, and the first electrocardiogram signal curve reflects the change of the electrocardiogram signal of the target object within the first time period.

[0036] In an embodiment of the present application, calculating the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve may include: calculating the time difference between the characteristic value of the first blood flow velocity curve and the time corresponding to the characteristic value of the first electrocardiogram signal curve in the same cardiac cycle. The characteristic value of the first blood flow velocity curve and the characteristic value of the first electrocardiogram signal curve have the same phase or the same synchronization. The characteristic value of the first blood flow velocity curve may be a value that can reflect the characteristics of the blood flow velocity of a cardiac cycle, such as an extreme value; similarly, the characteristic value of the first electrocardiogram signal curve may be a value that reflects the characteristics of the electrocardiogram signal of a cardiac cycle, such as an extreme value. In one example, the characteristic value of the first blood flow velocity curve may be the peak value of the first blood flow velocity curve in a cardiac cycle; the characteristic value of the first electrocardiogram signal curve may be the peak value of the first electrocardiogram signal curve in the cardiac cycle (also called the R wave peak value). Therefore, the heart and blood vessel synchronization index of the target object can be calculated based on the peak value of the first blood flow velocity curve and the peak value of the first electrocardiogram signal curve in the same cardiac cycle. In another example, the above-mentioned characteristic value may also be a value near the peak value; or a segment may be taken on the first blood flow velocity curve, and another segment on the first electrocardiogram signal curve correspondingly meeting the correlation condition, and the medians of these two segments of the curve are respectively used as characteristic values ​​with the same phase or the same timing; or other characteristic values ​​on the two curves that meet the same phase or the same timing are also possible, and this application does not limit this.

[0037] Figure 1 In the illustrated embodiment, the first blood flow velocity curve and the first electrocardiogram signal curve are signal curves acquired in the same time period. In another embodiment, the time period for acquiring the first blood flow velocity curve and the first electrocardiogram signal curve may not be limited. They may be two groups of signal curves acquired in different time periods or two groups of signal curves acquired in the same time period. For the two groups of signal curves acquired in different time periods, the first blood flow velocity curve and the first electrocardiogram signal curve may be mapped to the same time axis based on the periodic parameters of the target object, and then the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve may be calculated to obtain the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve of the first target site. The periodic parameters may include at least one of pulse parameters, blood pressure parameters, and cardiac parameters.

[0038] In one embodiment, multiple phase time differences between the first blood flow velocity curve and the first electrocardiogram signal curve of the first target part measured at different periods can also be obtained; and the evaluation result of the synchronization between the heart and blood vessels of the target object can be obtained according to the change of the multiple phase time differences. For example, multiple phase time differences obtained by multiple measurements performed irregularly on a yearly, monthly, and daily basis can be obtained to obtain the change trend of the multiple phase time differences, thereby obtaining the evaluation result of the synchronization between the heart and blood vessels of the target object.

[0039] In the embodiment of the present application, the time difference between the peak of the first blood flow velocity curve and the peak of the first electrocardiogram signal curve in the same cardiac cycle can be calculated to obtain the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve of the first target part of the target object. Figure 2 to describe.

[0040] Figure 2 FIG. 1 is a schematic diagram showing a phase time difference between a blood flow velocity curve and an electrocardiogram signal curve obtained in a measurement method based on ultrasonic blood flow imaging according to an embodiment of the present application. Figure 2 As shown, the first blood flow velocity curve is represented by 210, and the first electrocardiogram signal curve is represented by 220. The phase time difference between the first blood flow velocity curve 210 and the first electrocardiogram signal curve 220 in the same cardiac cycle is shown as follows: Figure 2 As shown, the phase time difference can be considered as the phase time difference between the ECG signal curve and the blood flow velocity curve of the first target site.

[0041] In an embodiment of the present application, the first blood flow velocity curve and the first electrocardiogram signal curve can be synchronously displayed in the first display area, and the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve can be marked. In addition, the ultrasonic blood flow image of the first target part can be displayed in the second display area. Based on such a display, the blood flow image, the blood flow velocity curve, the electrocardiogram signal curve, and the phase time difference between the blood flow velocity curve and the electrocardiogram signal curve are all clear at a glance, and the user can comprehensively analyze the synchronization of the heart and blood vessels of the target object in combination with these multiple diagrams.

[0042] Figure 3 An example of display is shown. Figure 3 As shown, an ultrasonic blood flow image 310, a blood flow velocity curve 320 and an electrocardiogram signal curve 330 are shown. The ultrasonic blood flow image 310 is a vector blood flow image, that is, the blood flow velocity in the blood flow velocity curve 320 is a vector blood flow velocity. Figure 3 As shown, the vector blood flow image 310 includes a grayscale image of vascular tissue and a static or dynamic marker 311 superimposed on the vascular area of ​​the grayscale image. The direction of the marker 311 represents the speed direction of the vector blood flow velocity, and the size or transparency of the marker 311 represents the speed magnitude of the vector blood flow velocity. Here, the size of the marker can be measured in different ways according to the different shapes of the marker. For example, the marker can be an arrow, in which case the size of the marker can include but is not limited to the length and thickness of the arrow. For another example, the marker can be a circle, in which case the size of the marker can include the area and size of the circle, etc. Figure 3In the figure, the marker 311 is shown as an arrow. For example, the size of the arrow end can represent the speed, or the length or thickness of the line segment connected to the arrow end can represent the speed, or a combination of the two can represent the speed, etc.

[0043] Exemplarily, the vector blood flow velocity is represented by a dynamic marker on an ultrasonic blood flow image, including: the position of the marker on two adjacent frames of ultrasonic blood flow images is dynamically updated to form a flow-like effect that changes over time, wherein the position of the marker represents the corresponding position of the blood flow in the vascular tissue. It should be noted that the dynamic display of the vector blood flow can be presented by displaying a dynamic marker on the ultrasonic blood flow image. The specific implementation can refer to the following description: First, the magnitude and direction of the vector blood flow velocity of the blood flow in the current frame are obtained, and then some markers are randomly displayed in the ultrasonic image of the vascular tissue. Among them, these markers can be symbols such as arrows, triangles, and circles. According to the magnitude and direction of the vector blood flow velocity of the blood flow corresponding to the position of each marker in the current frame, combined with the time interval between two adjacent frames, the position of the marker in the next frame is calculated, and then the marker is displayed. By analogy, when several frames of images are displayed together, the flow effect of blood flow can be visually presented.

[0044] The above exemplarily illustrates a measurement method 100 based on ultrasonic blood flow imaging according to an embodiment of the present application. Based on the above description, the measurement method 100 based on ultrasonic blood flow imaging according to an embodiment of the present application combines ultrasonic blood flow imaging with an electrocardiogram, and can obtain the phase time difference between the blood flow velocity curve and the electrocardiogram signal curve, which provides support for measuring the synchronization index of the heart and blood vessels.

[0045] Figure 4 FIG. 4 shows a measurement method 400 based on ultrasound blood flow imaging according to another embodiment of the present application. Figure 4 As shown, the measurement method 400 based on ultrasonic blood flow imaging may include the following steps:

[0046] In step S410, ultrasonic blood flow imaging is performed on vascular tissue at a first target site of the target object to obtain a first blood flow velocity curve of the vascular tissue at the first target site within a first time period, and electrocardiogram detection is performed on the target object to obtain a first electrocardiogram signal curve of the target object within the first time period.

[0047] In step S420, ultrasonic blood flow imaging is performed on the vascular tissue of the second target part of the target object to obtain a second blood flow velocity curve of the vascular tissue of the second target part in a second time period, and electrocardiogram detection is performed on the target object to obtain a second electrocardiogram signal curve of the target object in the second time period.

[0048] In step S430, a phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve is calculated as a first phase time difference;

[0049] In step S440, a phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve is calculated as a second phase time difference;

[0050] In step S450, the time difference between the first phase time difference and the second phase time difference is calculated to obtain the phase time difference between the first blood flow velocity curve and the second blood flow velocity curve.

[0051] The measurement method 400 based on ultrasonic blood flow imaging according to the embodiment of the present application is similar to the measurement method 100 based on ultrasonic blood flow imaging described above, and its steps S410 and S430 are respectively the same as steps S110 and S120 in the measurement method 100 based on ultrasonic blood flow imaging, and both are to calculate the phase time difference (referred to as the first phase time difference) between the first blood flow velocity curve of the vascular tissue of the first target part of the target object in the first time period and the first electrocardiogram signal curve of the target object in the first time period; the difference is that the measurement method 400 based on ultrasonic blood flow imaging also includes steps S420, S440 and S450, wherein step S420 Step S40 and step S440 are for calculating the phase time difference (referred to as the second phase time difference) between the second blood flow velocity curve of the vascular tissue of the second target part of the target object in the second time period and the second electrocardiogram signal curve of the target object in the second time period; and, in the measurement method 400 based on ultrasonic blood flow imaging according to the embodiment of the present application, the phase time difference between the first blood flow velocity curve and the second blood flow velocity curve is also calculated based on the aforementioned first phase time difference and second phase time difference, so as to obtain the phase time difference of the blood flow velocity curves of the two parts when the blood flow is transmitted from the first target part to the second target part, thereby obtaining the evaluation result of the synchronization of the cardiovascular system of the target object.

[0052] Therefore, according to the measurement method 400 based on ultrasonic blood flow imaging of the embodiment of the present application, ultrasonic blood flow imaging is combined with the electrocardiogram twice, and each combination can obtain the phase time difference between the blood flow velocity curve of the vascular tissue of a target part and the electrocardiogram signal curve within a period of time. The phase time difference obtained by each combination can be subtracted to obtain the phase time difference of blood flow from one target part to another target part. In addition, since the electrocardiogram is combined twice and then subtracted, the delay error caused by the electrocardiogram data is eliminated, making the calculation result more accurate, so that the phase time difference of blood flow from one target part to another target part can be accurately calculated, and the phase time difference of the blood flow velocity curve of the two parts can be obtained to obtain the accurate result of the synchronization index of the cardiovascular system.

[0053] It should be noted that the blood flow velocity in the human body changes periodically, but the blood flow velocity at different positions at the same time is in different phases. In this application, the phase time difference of the blood flow velocity curve at different positions refers to the time difference between the phases of the blood flow velocity at different positions.

[0054] Similarly, the ECG signal also changes periodically, and the ECG signal at the same moment is different from the phase of the blood flow velocity at a certain location (which can be a heart cavity or other blood vessels). In this application, the phase time difference between the ECG signal and the blood flow velocity refers to the time difference between the ECG signal and the phase of the blood flow velocity at the above-mentioned location.

[0055] The phase time difference mentioned in the present application can also be understood as the time difference between the moments corresponding to the characteristic values ​​with the same phase or the same tone on the first curve and the second curve that change periodically on the same time axis. The first curve can be an ECG signal curve or a blood flow velocity curve, and the second curve can be an ECG signal curve or a blood flow velocity curve. For example, taking the curves corresponding to two groups of signals (such as blood flow velocity signals and ECG signals) as an example, the characteristic values ​​with the same phase or the same tone in the curves corresponding to the two groups of signals are determined, and the curves corresponding to the two groups of signals are mapped to the same time axis. The difference between the moments at which the characteristic values ​​with the same phase or the same tone in the curves corresponding to the above two groups of signals are located can be calculated, and the difference is the phase time difference of the curves corresponding to the two groups of signals. For another example, the cross-correlation method, that is, the cross-correlation function and its properties, can be used to perform corresponding processing on the two groups of signals. When the correlation coefficient obtained by the corresponding calculation and deformation processing using the cross-correlation function reaches the maximum value, it means that the phase difference of the two groups of deformed signals is zero (or the phase difference is the minimum). At this time, the delayed signal (i.e., independent variable) in the cross-correlation function is the phase difference between the two groups of signals, and since both groups of signals are signals in the time domain, they are called phase time difference. Since the two groups of signals are signals in the time domain, the same time axis should be used when performing corresponding processing. On the same time axis, the phase time difference of the curves corresponding to the two groups of signals can be determined using the above-mentioned cross-correlation function, or it can be determined based on the difference between the moments at which the characteristic values ​​with the same phase or the same synchronization in the curves corresponding to the two groups of signals are located. The same time axis mentioned in this application can be understood as two identical time axes or the same time axis.

[0056] In an embodiment of the present application, the first target site of the target object in step S410 and the second target site in step S420 may be different arteries; or, the first target site and the second target site may be different chambers of the heart (for example, the first target site is the right atrium and the second target site is the right ventricle, or the first target site is the left atrium and the second target site is the left ventricle, etc.); or, one of the first target site and the second target site is a cardiac chamber and the other is an artery (for example, the first target site is the left ventricle and the second target site is the carotid artery, etc.).

[0057] In an embodiment of the present application, ultrasonic blood flow imaging is performed on the vascular tissue of the first target part of the target object to obtain a first blood flow velocity curve of the vascular tissue of the first target part in a first time period, and the first blood flow velocity curve reflects the change of the blood flow velocity in the vascular tissue of the first target part in the first time period. Similarly, ultrasonic blood flow imaging is performed on the vascular tissue of the second target part of the target object to obtain a second blood flow velocity curve of the vascular tissue of the second target part in a second time period, and the second blood flow velocity curve reflects the change of the blood flow velocity in the vascular tissue of the second target part in the second time period. Among them, the blood flow velocity in the first blood flow velocity curve may include a vector blood flow velocity or a blood flow velocity measured based on a pulse Doppler. Similarly, the blood flow velocity in the second blood flow velocity curve may include a vector blood flow velocity or a blood flow velocity measured based on a pulse Doppler. Exemplarily, the above-mentioned vector blood flow velocity can be calculated by a speckle tracking method, a transverse wave oscillation method, or a multi-angle deflection transmission and / or receiving method based on the Doppler principle.

[0058] In addition, the target object may be subjected to an electrocardiogram detection to obtain a first electrocardiogram signal curve of the target object in a first time period, and calculate a first phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve; and obtain a second electrocardiogram signal curve of the target object in a second time period, and calculate a second phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve. Here, the first time period may be the same time period as the second time period, or may be a different time period. When the first time period and the second time period are the same time period, the first electrocardiogram signal curve and the second electrocardiogram signal curve are the same electrocardiogram signal curve.

[0059] Similar to the above, calculating the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve may include: calculating the time difference between the time points corresponding to the characteristic value of the first blood flow velocity curve and the characteristic value of the first electrocardiogram signal curve in the same cardiac cycle, wherein the characteristic value of the first blood flow velocity curve and the characteristic value of the first electrocardiogram signal curve have the same phase or the same synchronization. The characteristic value of the first blood flow velocity curve may be a value that can reflect the characteristics of the blood flow velocity in one cardiac cycle, such as an extreme value; similarly, the characteristic value of the first electrocardiogram signal curve may be a value that reflects the characteristics of the electrocardiogram signal in one cardiac cycle, such as an extreme value. In one example, the characteristic value of the first blood flow velocity curve may be the peak value of the first blood flow velocity curve in one cardiac cycle; the characteristic value of the first electrocardiogram signal curve may be the peak value of the first electrocardiogram signal curve in the cardiac cycle. Therefore, the heart and blood vessel synchronization index of the target object may be calculated based on the peak value of the first blood flow velocity curve and the peak value of the first electrocardiogram signal curve in the same cardiac cycle.

[0060] Similarly, calculating the phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve may include: calculating the time difference between the time points corresponding to the characteristic value of the second blood flow velocity curve and the characteristic value of the second electrocardiogram signal curve in the same cardiac cycle, wherein the characteristic value of the second blood flow velocity curve and the characteristic value of the second electrocardiogram signal curve have the same phase or the same synchronization. The characteristic value of the second blood flow velocity curve may be a value that can reflect the characteristics of the blood flow velocity in one cardiac cycle, such as an extreme value; similarly, the characteristic value of the second electrocardiogram signal curve may be a value that reflects the characteristics of the electrocardiogram signal in one cardiac cycle, such as an extreme value. In one example, the characteristic value of the second blood flow velocity curve may be the peak value of the second blood flow velocity curve in one cardiac cycle; the characteristic value of the second electrocardiogram signal curve may be the peak value of the second electrocardiogram signal curve in the cardiac cycle. Therefore, the heart and blood vessel synchronization index of the target object may be calculated based on the peak value of the second blood flow velocity curve and the peak value of the second electrocardiogram signal curve in the same cardiac cycle.

[0061] In the embodiment of the present application, the time difference between the peak of the first blood flow velocity curve and the peak of the first electrocardiogram curve in the same cardiac cycle can be calculated to obtain the first phase time difference between the first blood flow velocity curve and the first electrocardiogram curve of the first target part of the target object; the time difference between the peak of the second blood flow velocity curve and the peak of the second electrocardiogram curve in the same cardiac cycle can be calculated to obtain the second phase time difference between the second blood flow velocity curve and the second electrocardiogram curve of the second target part of the target object. Figure 5 and Figure 6 to describe.

[0062] Figure 5 FIG. 2 is a schematic diagram showing a first phase time difference obtained in a measurement method based on ultrasound blood flow imaging according to another embodiment of the present application. Figure 5 In FIG. 5 , the first target site is shown as a cardiac cavity, the corresponding blood flow velocity curve is represented by 510, and the ECG signal curve in the same time period is represented by 520. The phase time difference between the blood flow velocity curve 510 and the ECG signal curve 520 in the same cardiac cycle is as follows: Figure 5 As shown, the phase time difference can be considered as the phase time difference between the electrocardiogram signal curve and the intracardiac blood flow velocity curve, which is expressed as T0.

[0063] Figure 6 FIG. 2 is a schematic diagram showing a second phase time difference obtained in a measurement method based on ultrasound blood flow imaging according to another embodiment of the present application. Figure 6 In FIG. 1 , the second target site is shown as the carotid artery, the corresponding blood flow velocity curve is represented by 610, and the ECG signal curve in the same time period is represented by 620. The phase time difference between the blood flow velocity curve 610 and the ECG signal curve 620 in the same cardiac cycle is as follows: Figure 6 As shown, the phase time difference can be considered as the phase time difference between the ECG signal curve and the carotid artery blood flow velocity curve, which is expressed as T1.

[0064] In the embodiment of the present application, the phase time difference between the first blood flow velocity curve and the second blood flow velocity curve is calculated according to the first phase time difference and the second phase time difference, so as to obtain the phase time difference of the blood flow velocity curves of the two parts when the blood flow is transferred from the first target part to the second target part. Figure 5 and Figure 6 In the example shown, the phase time difference T1-T0 of the blood flow velocity curve of blood flow transmitted from the cardiac chamber to the carotid artery can be obtained by calculating the difference between T1 and T0.

[0065] In an embodiment of the present application, method 400 may also include: synchronously displaying the first blood flow velocity curve and the first electrocardiogram signal curve in the first display area, and marking the first phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve; synchronously displaying the second blood flow velocity curve and the second electrocardiogram signal curve in the second display area, and marking the second phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve. Based on such a display, the first blood flow velocity curve, the first electrocardiogram signal curve, the first phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve, the second blood flow velocity curve, the second electrocardiogram signal curve, and the second phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve are all clear at a glance, and the user can clearly view the phase time difference between the blood flow velocity curve and the electrocardiogram signal curve, as well as the blood flow from one target site to another target site, and the phase time difference of the blood flow velocity curves of the two sites, which makes it easier to comprehensively analyze the synchronization of the cardiovascular system of the target object.

[0066] The above exemplifies a measurement method 400 based on ultrasonic blood flow imaging according to another embodiment of the present application. Based on the above description, the measurement method 400 based on ultrasonic blood flow imaging according to another embodiment of the present application combines ultrasonic blood flow imaging of two different target parts with an electrocardiogram, and can obtain the phase time difference between the blood flow velocity curves of the two different parts and the electrocardiogram signal curve, and obtain the blood flow from one target part to another target part based on the two obtained phase time differences. The phase time difference of the blood flow velocity curves of the two parts can eliminate the delay error caused by the electrocardiogram data and obtain accurate results of the cardiovascular synchronization index.

[0067] Figure 7 FIG. 7 is a schematic flow chart of a measurement method 700 based on ultrasound blood flow imaging according to another embodiment of the present application. Figure 7 As shown, the measurement method 700 based on ultrasonic blood flow imaging may include the following steps:

[0068] In step S710, ultrasonic blood flow imaging is performed on vascular tissue at a first target site of the target object to obtain an ultrasonic blood flow image of the vascular tissue at the first target site within a first time period, wherein an imaging frame rate of the ultrasonic blood flow imaging is greater than 60 Hz.

[0069] In step S720, a first position and a second position are determined in a blood vessel region of the ultrasonic blood flow image.

[0070] In step S730, a first blood flow velocity curve of the blood flow at the first position in the first time period and a second blood flow velocity curve of the blood flow at the second position in the first time period are acquired based on the ultrasonic echo signal in the ultrasonic blood flow imaging process.

[0071] In step S740, a first phase time difference between the second blood flow velocity curve and the first blood flow velocity curve is calculated to obtain a first phase time difference between the second blood flow velocity curve at the second position and the first blood flow velocity curve at the first position.

[0072] Compared with the measurement methods 100 and 400 based on ultrasonic blood flow imaging described above, the measurement method 700 based on ultrasonic blood flow imaging according to the embodiment of the present application does not need to be combined with an electrocardiogram curve, but obtains blood flow velocity curves of two positions of a vascular tissue of a target part of the target object in the same time period, and calculates the phase time difference of the two blood flow velocity curves based on the blood flow velocity curves of the two positions to obtain the phase time difference of the blood flow velocity curves of one position and another position in the blood flow. Since the two positions are obtained in the same ultrasonic blood flow image of the vascular tissue of the target part (for example, Figure 8 The L1 position and L2 position shown in the figure are suitable for calculating the synchronization index of the local cardiovascular system. And because the distance between the two positions in the local blood flow image is limited, a certain display frame rate is required to capture the time difference. Based on this, in this embodiment of the present application, a high frame rate (such as an imaging frame rate of at least 60 Hz) is used for ultrasonic blood flow imaging.

[0073] In an embodiment of the present application, calculating the first phase time difference between the second blood flow velocity curve and the first blood flow velocity curve may include: calculating the time difference between the moments corresponding to the characteristic value of the second blood flow velocity curve and the characteristic value of the first blood flow velocity curve in the same cardiac cycle, wherein the characteristic value of the second blood flow velocity curve has the same phase or the same synchronization as the characteristic value of the first blood flow velocity curve. The characteristic value of the first blood flow velocity curve may include: the peak value of the first blood flow velocity curve in one cardiac cycle; the characteristic value of the second blood flow velocity curve may include: the peak value of the second blood flow velocity curve in the cardiac cycle.

[0074] A measurement method based on ultrasonic blood flow imaging in another embodiment of the present application may include the following steps:

[0075] Performing ultrasonic blood flow imaging on the vascular tissue of the target object to obtain a first blood flow velocity curve of blood flow at a first position within a first time period and a second blood flow velocity curve of blood flow at a second position within the first time period;

[0076] A first phase time difference between the second blood flow velocity curve and the first blood flow velocity curve is calculated to obtain a phase time difference between the second blood flow velocity curve at the second position and the first blood flow velocity curve at the first position.

[0077] Compared with the measurement methods 100 and 400 based on ultrasonic blood flow imaging described above, the measurement method based on ultrasonic blood flow imaging according to the embodiment of the present application does not need to be combined with an electrocardiogram curve, but obtains the blood flow velocity curves of the blood flow at two different positions of the vascular tissue of the target object in the same time period, and calculates the phase time difference of the two blood flow velocity curves based on the blood flow velocity curves at the two different positions to obtain the phase time difference of the blood flow velocity curves at one position and another position in the blood flow. The two different positions can be two different positions in the same vascular tissue of the target object (i.e., the same ultrasonic blood flow image), or two different positions in different vascular tissues of the target object (i.e., different ultrasonic blood flow images). Compared with the aforementioned ultrasonic blood flow imaging measurement method 700, the embodiment of the present application is not limited to the calculation of the local cardiovascular system synchronization index, and can also calculate the phase time difference of the blood flow velocity curves at different vascular tissues to obtain accurate results of the cardiovascular system synchronization index between different parts.

[0078] In one embodiment, for two different positions in different vascular tissues, two ultrasound probes may be attached to the corresponding positions respectively to collect data simultaneously. In this embodiment, performing ultrasound blood flow imaging on the vascular tissue of the target object includes: controlling a first ultrasound probe to emit a first ultrasound wave to the blood flow at a first position, and controlling a second ultrasound probe to emit a second ultrasound wave to the blood flow at the second position;

[0079] receiving an echo of a first ultrasonic wave to obtain a first ultrasonic echo signal, and receiving an echo of a second ultrasonic wave to obtain a second ultrasonic echo signal;

[0080] The first ultrasonic echo signal is processed to obtain a first blood flow velocity curve, and the second ultrasonic echo signal is processed to obtain a second blood flow velocity curve.

[0081] Fig. 9 FIG. 1 is a schematic diagram showing a phase time difference of a blood flow velocity curve at a first position and a second position in a blood flow obtained in a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application. Fig. 9 As shown, Figure 8 The blood flow velocity curve at the L1 position is represented as 910. Figure 8The blood flow velocity curve at the position L2 is represented as 920. The time difference between the moments corresponding to the peak values ​​of the blood flow velocity curve 910 and the blood flow velocity curve 920 in the same cardiac cycle is the phase time difference between the blood flow velocity curves at the first position L1 and the second position L2 in the blood flow.

[0082] In a further embodiment of the present application, method 700 may also include: determining a third position in the vascular area of ​​the ultrasonic blood flow image; acquiring a third blood flow velocity curve of the third position within the first time period based on the ultrasonic echo signal during the ultrasonic blood flow imaging process; calculating the phase time difference between the third blood flow velocity curve and the second blood flow velocity curve, or calculating the phase time difference between the third blood flow velocity curve and the first blood flow velocity curve as the second phase time difference; determining whether there is an abnormality in the transfer of blood flow between the first position, the second position and the third position based on the first phase time difference and the second phase time difference and / or determining the degree of influence of known objects between the first position, the second position and the third position on the blood flow transfer. In this embodiment, the phase time difference of the blood flow velocity curves between the multiple positions when the blood flow is transferred to multiple positions in the vascular area of ​​the ultrasonic blood flow image can be measured, and whether the blood flow transfer is abnormal can be determined by comparing the phase time difference of the blood flow velocity curves at different positions. The following is combined with Fig.10 and Fig.11 The examples shown are described.

[0083] Fig.10 A schematic diagram showing three positions in a blood vessel region of an ultrasonic blood flow image in a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application. Fig.11 A schematic diagram showing the phase time difference between the blood flow velocity curves at the first position and the second position in the blood flow, and the phase time difference between the blood flow velocity curves at the second position and the third position in the blood flow in a measurement method based on ultrasonic blood flow imaging according to another embodiment of the present application is shown. Fig.10 As shown, three positions L4, L5 and L6 are shown, wherein according to the method of the present application, the blood flow velocity curves of these three positions in the same time period can be obtained respectively, such as Fig.11 As shown, the blood flow velocity curve at the L4 position is represented as 1110, the blood flow velocity curve at the L5 position is represented as 1120, and the blood flow velocity curve at the L6 position is represented as 1130. According to the above method of the embodiment of the present application, the first phase time difference of the blood flow velocity curve at the L4 position and the L5 position in the blood flow can be obtained, and the second phase time difference of the blood flow velocity curve at the L5 position and the L6 position in the blood flow can also be obtained. Fig.10 It can be seen that the distance from L4 to L5 is almost equal to the distance from L5 to L6, but Fig.11It can be seen that there is a certain difference between the first phase time difference of the blood flow velocity curve between the L4 position and the L5 position and the second phase time difference of the blood flow velocity curve between the L5 position and the L6 position. Fig.10 It can be seen that this is due to the presence of a plaque between the L5 position and the L6 position, and the presence of the plaque slows down the blood flow. In the embodiment of the present application, the degree of influence of the plaque on blood flow transmission can also be determined by the difference between the first phase time difference and the second phase time difference.

[0084] Commonly used sections for ultrasound scanning are cross sections and longitudinal sections. Among them, the cross section generally refers to the section along the short axis direction, and the longitudinal section generally refers to the section along the long axis direction. The above is mainly described by taking the local position on the longitudinal section of the blood vessel as an example. In the embodiment of the present application, the phase time difference of the blood flow velocity curve between different positions on the cross section of the blood vessel (circumferential direction of the blood vessel) can also be measured. Since the distance between different positions on the cross section of the blood vessel is more limited, a larger display frame rate is required to capture the time difference. Based on this, in this embodiment of the present application, an imaging frame rate of at least 1000 Hz is used for ultrasonic blood flow imaging. The following is combined with Fig.12 and Fig.13 to describe.

[0085] Fig.12 A schematic diagram showing three positions in a cross-sectional blood vessel of an ultrasonic blood flow image in a measurement method based on ultrasonic blood flow imaging according to yet another embodiment of the present application. Fig.13 A schematic diagram showing the phase time difference between the blood flow velocity curves at the first position and the second position of the cross-section of the blood flow, and the phase time difference between the blood flow velocity curves at the second position and the third position in a measurement method based on ultrasound blood flow imaging according to another embodiment of the present application. Fig.12 As shown, three positions L7, L8 and L9 are shown, wherein according to the method of the present application, the blood flow velocity curves of these three positions in the same time period can be obtained respectively, such as Fig.13 As shown, the blood flow velocity curve at the L7 position is represented as 1310, the blood flow velocity curve at the L8 position is represented as 1320, and the blood flow velocity curve at the L9 position is represented as 1330. According to the above method of the embodiment of the present application, the first phase time difference of the blood flow velocity curves at the L7 position and the L8 position in the blood flow can be obtained, and the second phase time difference of the blood flow velocity curves at the L8 position and the L9 position in the blood flow can also be obtained.

[0086] Similar to the above-mentioned embodiment, in a further embodiment of the present application, the blood flow velocity corresponding to the blood flow velocity curve mentioned in method 700 may also include a vector blood flow velocity or a blood flow velocity measured based on pulse Doppler; wherein the vector blood flow velocity is calculated by a speckle tracking method, a transverse wave oscillation method, or a multi-angle deflection transmission and / or receiving method based on the Doppler principle. In addition, the ultrasonic blood flow image is a vector blood flow image, and method 700 may also include displaying the vector blood flow image; wherein the vector blood flow image includes a grayscale image of the vascular tissue and a static or dynamic marker superimposed and displayed on the vascular area of ​​the grayscale image, the direction of the marker indicates the velocity direction of the vector blood flow velocity, and the size or transparency of the marker indicates the velocity magnitude of the vector blood flow velocity. wherein the position of the dynamic marker on two adjacent frames of the vector blood flow image is dynamically updated to form a flow-like effect that changes with time, wherein the position of the marker indicates the corresponding position of the blood flow in the vascular tissue. Furthermore, method 700 may also include synchronously displaying the first blood flow velocity curve and the second blood flow velocity curve in the first display area, and marking the first phase time difference between the second blood flow velocity curve and the first blood flow velocity curve; and displaying the vector blood flow image in the second display area.

[0087] Based on the above description, the measurement method 700 based on ultrasonic blood flow imaging according to the embodiment of the present application can obtain the blood flow velocity curves of two positions of the vascular tissue of a target part of the target object in the same time period, and obtain the phase time difference between the blood flow velocity curves of one position and another position in the blood flow according to the blood flow velocity curves of the two positions. Since the two positions are obtained in the same ultrasonic blood flow image of the vascular tissue of the target part, it is suitable for the calculation of the synchronization index of the local cardiovascular system. And because the distance between the two positions in the local blood flow image is limited, a certain imaging frame rate is required to capture the time difference. Based on this, this embodiment of the present application is suitable for the calculation of the synchronization index of the local cardiovascular system in high frame rate blood flow imaging.

[0088] In one example, the blood flow from the heart is transmitted to the common carotid artery. In most cases, the phase time difference of a normal person is about 0.15s, and the distance between the two blood flows in the blood vessel may be about 30cm; for a local blood flow image, the distance between the two points may be only 1cm, so the phase time difference may be only 5ms, so the imaging frame rate needs to be at least 200Hz to capture this time difference. For more accurate calculations, the imaging frame rate usually needs to reach 1000-2000Hz or even higher to meet the requirements of accurate calculations. For the distance between the two points on the cross section of the blood vessel, it may be smaller, only a few millimeters or even less than one millimeter, so the phase time difference may be less than 1ms, so the imaging frame rate needs to be at least 1000Hz to capture this time difference. For more accurate calculations, the imaging frame rate needs to reach 5000-10000Hz or even higher to meet the requirements of accurate calculations. Among them, when the blood flow velocity is measured on the cross section of the blood vessel using two-dimensional vector blood flow imaging technology, the velocity component of the blood flow on the cross section of the blood vessel is obtained.

[0089] The above exemplary shows the measurement method based on ultrasound blood flow imaging according to the embodiment of the present application. Fig.14 The ultrasonic blood flow imaging device provided according to another aspect of the present application is described. Fig.14 FIG. 1 shows a schematic structural block diagram of an ultrasonic blood flow imaging device 1400 according to an embodiment of the present application. Fig.14 As shown, the ultrasonic blood flow imaging device 1400 includes a transmitting circuit 1420, a receiving circuit 1430, an ultrasonic probe 1410 and a processor 1440, wherein: the transmitting circuit 1420 is used to control the ultrasonic probe 1410 to transmit ultrasonic waves to the target part of the target object; the receiving circuit 1430 is used to control the ultrasonic probe 1410 to receive the echo of the ultrasonic wave and obtain an ultrasonic echo signal from the echo of the ultrasonic wave; the processor 1440 is used to perform ultrasonic blood flow imaging based on the ultrasonic echo signal, and is also used to execute the measurement method based on ultrasonic blood flow imaging according to the embodiment of the present application described above. Those skilled in the art can understand the structure and operation of the ultrasonic blood flow imaging device 1400 according to the embodiment of the present application in combination with the description of the measurement method based on ultrasonic blood flow imaging according to the embodiment of the present application in the above text. For the sake of brevity, the specific detailed operation of each component of the ultrasonic blood flow imaging device 1400 will not be repeated here.

[0090] Based on the above description, according to the measurement method based on ultrasonic blood flow imaging and the ultrasonic blood flow imaging device of the embodiment of the present application, ultrasonic blood flow imaging can be combined with an electrocardiogram to obtain the phase time difference between the blood flow velocity curve and the electrocardiogram signal curve, which provides support for measuring the synchronization index of the cardiovascular system. In addition, according to the measurement method based on ultrasonic blood flow imaging and the ultrasonic blood flow imaging device of the embodiment of the present application, ultrasonic blood flow imaging of two different target parts can be combined with an electrocardiogram to obtain the phase time difference between the blood flow velocity curves of two different parts and the electrocardiogram signal curve, and the blood flow is transferred from one target part to another target part based on the two obtained phase time differences. The phase time difference of the blood flow velocity curves of the two parts can eliminate the influence of the delay error between the electrocardiogram signal and the blood flow, and obtain accurate results of the synchronization index of the cardiovascular system. In addition, the measurement method based on ultrasonic blood flow imaging and the ultrasonic blood flow imaging device according to the embodiments of the present application can obtain the blood flow velocity curves of two positions of the vascular tissue of a target part of the target object in the same time period, and obtain the phase time difference between the blood flow velocity curves at one position and another position in the blood flow based on the blood flow velocity curves of the two positions, which is suitable for calculating the synchronization index of the local cardiovascular system in high frame rate blood flow imaging.

[0091] Although example embodiments have been described herein with reference to the accompanying drawings, it should be understood that the above example embodiments are merely exemplary and are not intended to limit the scope of the present application to this. Those of ordinary skill in the art may make various changes and modifications therein without departing from the scope and spirit of the present application. All these changes and modifications are intended to be included within the scope of the present application as required by the appended claims.

[0092] Those of ordinary skill in the art will appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professional and technical personnel can use different methods to implement the described functions for each specific application, but such implementation should not be considered to be beyond the scope of this application.

[0093] In the several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are only schematic, for example, the division of the units is only a logical function division, and there may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another device, or some features can be ignored or not executed.

[0094] In the description provided herein, a large number of specific details are described. However, it is understood that the embodiments of the present application can be practiced without these specific details. In some instances, well-known methods, structures and techniques are not shown in detail so as not to obscure the understanding of this description.

[0095] Similarly, it should be understood that in order to streamline the present application and help understand one or more of the various inventive aspects, in the description of the exemplary embodiments of the present application, the various features of the present application are sometimes grouped together into a single embodiment, figure, or description thereof. However, the method of the present application should not be interpreted as reflecting the following intention: the claimed application requires more features than the features clearly stated in each claim. More specifically, as reflected in the corresponding claims, the inventive point is that the corresponding technical problem can be solved with features less than all the features of a single disclosed embodiment. Therefore, the claims following the specific embodiment are hereby explicitly incorporated into the specific embodiment, wherein each claim itself serves as a separate embodiment of the present application.

[0096] It will be understood by those skilled in the art that, except for mutually exclusive features, all features disclosed in this specification (including the accompanying claims, abstracts and drawings) and all processes or units of any method or device disclosed in this specification may be combined in any combination. Unless otherwise expressly stated, each feature disclosed in this specification (including the accompanying claims, abstracts and drawings) may be replaced by an alternative feature that provides the same, equivalent or similar purpose.

[0097] In addition, those skilled in the art will appreciate that, although some embodiments described herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present application and form different embodiments. For example, in the claims, any one of the claimed embodiments can be used in any combination.

[0098] The various component embodiments of the present application can be implemented in hardware, or in software modules running on one or more processors, or in a combination thereof. It should be understood by those skilled in the art that a microprocessor or digital signal processor (DSP) can be used in practice to implement some or all of the functions of some modules in the article analysis device according to the embodiment of the present application. The present application can also be implemented as an ultrasonic blood flow imaging device program (e.g., computer program and computer program product) for executing part or all of the methods described herein. Such a program implementing the present application can be stored on a computer-readable medium, or can have the form of one or more signals. Such a signal can be downloaded from an Internet website, or provided on a carrier signal, or provided in any other form.

[0099] It should be noted that the above embodiments illustrate the present application rather than limit the present application, and that those skilled in the art may design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference symbol between brackets should not be constructed as a limitation on the claims. The word "comprising" does not exclude the presence of elements or steps not listed in the claims. The word "one" or "an" preceding an element does not exclude the presence of multiple such elements. The present application may be implemented with the aid of hardware comprising several different elements and with the aid of a suitably programmed computer. In a unit claim listing several ultrasonic blood flow imaging devices, several of these ultrasonic blood flow imaging devices may be embodied by the same hardware item. The use of the words first, second, and third, etc. does not indicate any order. These words may be interpreted as names.

[0100] The above is only a specific implementation or description of a specific implementation of the present application, and the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. The protection scope of the present application shall be based on the protection scope of the claims.

Claims

1. A measurement method based on ultrasonic blood flow imaging, characterized in that: The method comprises: Performing ultrasonic blood flow imaging on vascular tissue at a first target site of a target object to obtain a first blood flow velocity curve of the vascular tissue at the first target site in a first time period, and performing electrocardiogram detection on the target object to obtain a first electrocardiogram signal curve of the target object in the first time period; Performing ultrasonic blood flow imaging on the vascular tissue of the second target part of the target object to obtain a second blood flow velocity curve of the vascular tissue of the second target part in a second time period, and performing electrocardiogram detection on the target object to obtain a second electrocardiogram signal curve of the target object in the second time period; Calculating a phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve as a first phase time difference; calculating a phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve as a second phase time difference; The time difference between the first phase time difference and the second phase time difference is calculated to obtain the phase time difference between the first blood flow velocity curve and the second blood flow velocity curve.

2. The method according to claim 1, characterized in that The calculating of the phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve comprises: calculating the time difference between the moments corresponding to the characteristic value of the first blood flow velocity curve and the characteristic value of the first electrocardiogram signal curve in the same cardiac cycle, wherein the characteristic value of the first blood flow velocity curve and the characteristic value of the first electrocardiogram signal curve have the same phase or the same synchronization; The calculating of the phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve includes: calculating the time difference between the moments corresponding to the characteristic value of the second blood flow velocity curve and the characteristic value of the second electrocardiogram signal curve in the same cardiac cycle, wherein the characteristic value of the second blood flow velocity curve and the characteristic value of the second electrocardiogram signal curve have the same phase or the same synchronization.

3. The method according to claim 2, characterized in that The first time period and the second time period each include at least one cardiac cycle, The characteristic value of the first blood flow velocity curve includes: the peak value of the first blood flow velocity curve in one cardiac cycle; the characteristic value of the first electrocardiogram signal curve includes: the peak value of the first electrocardiogram signal curve in the cardiac cycle; The characteristic value of the second blood flow velocity curve includes: the peak value of the second blood flow velocity curve in one cardiac cycle; the characteristic value of the second electrocardiogram signal curve includes: the peak value of the second electrocardiogram signal curve in the cardiac cycle.

4. The method according to any one of claims 1 to 3, characterized in that: The first target site and the second target site are different arteries; or The first target site and the second target site are different chambers of the heart; or One of the first target site and the second target site is a heart chamber, and the other is an artery.

5. The method according to any one of claims 1 to 3, characterized in that: The method further comprises: Synchronously displaying the first blood flow velocity curve and the first electrocardiogram signal curve in a first display area, and marking the first phase time difference between the first blood flow velocity curve and the first electrocardiogram signal curve; The second blood flow velocity curve and the second electrocardiogram signal curve are synchronously displayed in the second display area, and the second phase time difference between the second blood flow velocity curve and the second electrocardiogram signal curve is marked.

6. The method according to any one of claims 1 to 3, characterized in that: The blood flow velocity corresponding to the blood flow velocity curve includes a vector blood flow velocity or a blood flow velocity measured based on a pulse Doppler; The vector blood flow velocity is calculated by a speckle tracking method, a transverse wave oscillation method, or a multi-angle deflection transmission and / or reception method based on the Doppler principle.

7. The method according to any one of claims 1 to 3, characterized in that: The method further comprises: An evaluation result of the synchronization of the cardiovascular system of the target object is obtained according to the phase time difference between the first blood flow velocity curve and the second blood flow velocity curve.

8. The method according to any one of claims 1 to 3, characterized in that: The method for calculating the phase time difference includes: calculating the phase time difference using a cross-correlation method.

9. An ultrasonic blood flow imaging device, characterized in that: The ultrasonic blood flow imaging device comprises a transmitting circuit, a receiving circuit, an ultrasonic probe and a processor, wherein: The transmitting circuit is used to control the ultrasonic probe to transmit ultrasonic waves to a target part of a target object; The receiving circuit is used to control the ultrasonic probe to receive the ultrasonic echo and obtain an ultrasonic echo signal from the ultrasonic echo; The processor is used for performing ultrasonic blood flow imaging based on the ultrasonic echo signal; The processor is also used to execute the measurement method based on ultrasonic blood flow imaging as described in any one of claims 1-8.

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