Eye movement monitoring and radiation dose monitoring method, storage medium and monitoring device during head and neck radiotherapy

Abstract

The present application relates to the field of radiotherapy technology, and in particular to a method, storage medium, and monitoring device for monitoring eye movement and radiation dose during head and neck radiotherapy. The method comprises: using an isodose curve to divide a human body into at least two regions, the at least two regions including a first region and a second region, wherein the first region receives a higher radiation dose per unit time than the second region; monitoring the patient's eye movements and calculating the time that the dose-sensitive portion of the patient's eye remains in the first region. By calculating the time that the dose-sensitive portion of the patient's eye remains in the first region, the present invention enables real-time monitoring of the time the eye receives radiation, facilitates guiding the patient's line of sight to avoid high-dose areas as needed, and assesses whether the extra radiation dose received by the lens and cornea due to misaligned eye movements adversely affects the patient's visual function.

Description

Technical Field

[0001] The present application relates to the technical field of radiotherapy, and in particular to a method, storage medium, and monitoring device for monitoring eye movement and radiation dose during head and neck radiotherapy. Background Art

[0002] With the rapid development of modern tumor radiotherapy technology, radiotherapy for head and neck tumors has entered the era of precision radiotherapy. Accurately locating the patient's tumor tissue and organs at risk is the most critical foundation for implementing precision treatment. During clinical radiotherapy for patients with head and neck tumors, tumor tissue often approaches or even involves important visual organs such as the lens and cornea. These organs have low tolerance to radiation and are prone to early and late visual damage such as conjunctivitis, scleral hemorrhage, keratitis, cataracts, glaucoma, panophthalmitis, and even blindness. Radiation-induced visual damage is often irreversible and the treatment effect is poor, so active prevention, timely detection, and timely treatment are crucial.

[0003] During actual head and neck cancer radiotherapy, patients may experience involuntary or unconscious eye movements, causing sensitive eye parts (such as the lens and cornea) to shift from their originally safe, low-dose areas to the adjacent, high-dose radiation treatment zone. Existing technologies cannot monitor the duration of radiation exposure to sensitive eye parts in real time. Summary of the Invention

[0004] In order to solve or at least partially solve the above technical problems, the present application provides a method for monitoring eye movement and radiation dose during head and neck radiotherapy, comprising:

[0005] Dividing a human body into at least two regions using an isodose curve, the at least two regions comprising a first region and a second region, wherein the radiation dose received by the first region per unit time is higher than that received by the second region;

[0006] Monitor the patient's eye movements and count the time the dose-sensitive part of the patient's eye stays in the first area.

[0007] The human body can be divided into at least two areas using isodose curves. During radiation therapy, the division of areas is used to ensure that the radiation acts mainly on the tumor area. Based on the patient's radiotherapy positioning CT image, the distance between the eyeball and the tumor target area can be obtained, and real-time monitoring of the patient's eyeball can be achieved. Compared with the existing technology, the present application counts the length of time that the dose-sensitive part of the patient's eyeball stays in the first area, which can determine the impact on the patient's eyes, making it convenient to guide the patient's line of sight to avoid high-dose areas as needed. In addition, based on the statistics of this length of time, the additional exposure dose to the lens and cornea caused by the mismovement of the eyeball can be evaluated, thereby providing data for the patient's prognosis of visual function problems.

[0008] Optionally, the statistical step further includes:

[0009] The radiation dose received by the dose-sensitive part of the patient's eyeball is calculated based on the length of time the dose-sensitive part of the patient's eyeball stays in the first area and the overlapping volume of the sensitive part with the first area during the exposure period.

[0010] By monitoring the duration of radiation exposure in real time, this application can determine how long sensitive areas remain in the first zone, allowing for guidance of the patient's gaze to avoid high-dose areas as needed. By calculating this dwell time, this application can assess the additional radiation dose to the lens and cornea due to erroneous eye movement, further evaluating the patient's prognostic visual function changes.

[0011] Optionally, the first region is further divided into a plurality of sub-regions by a dose segmentation line, and the average radiation dose intensity per unit volume of each sub-region is calculated;

[0012] In the statistical step, the radiation dose received by the sensitive part in each sub-region is counted and summed up.

[0013] Optionally, it also includes:

[0014] When the sensitive part stays in the first area and meets the first preset condition, an alarm prompt is issued;

[0015] The first preset condition includes one or any combination of the following preset conditions:

[0016] The sensitive part stays in the first area for longer than a first preset time;

[0017] The radiation dose received by the sensitive part during a single stay in the first area exceeds the first preset dose;

[0018] The cumulative radiation dose received by the sensitive part while staying in the first area exceeds the second preset dose.

[0019] Optionally, it also includes:

[0020] When the sensitive part stays in the first area and meets the second preset condition, suspending the radiation irradiation;

[0021] The second preset condition includes one or any combination of the following preset conditions:

[0022] The sensitive part stays in the first area for a time period exceeding a second preset time period;

[0023] The radiation dose received by the sensitive part during a single stay in the first area exceeds the third preset dose;

[0024] The cumulative radiation dose received by the sensitive part while staying in the first area exceeds the fourth preset dose.

[0025] Optionally, it also includes:

[0026] When the sensitive part leaves the first area and returns to the second area, and a third preset condition is met, continuing the radiation irradiation;

[0027] The third precondition includes one or any combination of the following preconditions:

[0028] The sensitive part completely leaves the first area for a period exceeding a third preset time period;

[0029] The cumulative radiation dose received by the sensitive part while staying in the first area is lower than the fifth preset dose.

[0030] Optionally, the sensitive parts are the lens and cornea of ​​the eye.

[0031] The present application also proposes a computer-readable storage medium storing a computer program, which, when executed by a processor, can implement the steps of any of the above-mentioned methods for monitoring eye movement and radiation dose in head and neck radiotherapy.

[0032] This application also proposes a device for monitoring eye movement and radiation dose during head and neck radiotherapy, comprising:

[0033] An eye monitoring device for monitoring the patient's eye movements;

[0034] A controller is connected to the radiotherapy device for communication and is used to:

[0035] Obtaining a dose per unit time of radiation acting on a human body, dividing the human body into at least two regions using a dose dividing line, the at least two regions including a first region and a second region, wherein the radiation dose per unit time received by the first region is higher than that received by the second region;

[0036] The controller counts the time that the dose-sensitive part of the patient's eye stays in the first area based on the eye movement feedback from the eye monitoring device.

[0037] Optionally, the eye monitoring device is installed on the radiotherapy bed and is located diagonally above the position of the patient's head when the patient lies down.

[0038] The technical solution of this application has promising application prospects. For example, a large number of patients can be selected to expand the basic database of the model, and the obtained eye movement data can be correlated with the dose data of the radiotherapy planning system to establish a generalizable mathematical model for eye positioning and protection during radiotherapy. This model can be used to form a new strategy for precise eye positioning and protection during radiotherapy, from precise positioning and control to precise treatment. This type of dynamic monitoring data model can be applied to more clinical fields. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] To more clearly illustrate the embodiments of the present application, the following briefly introduces the relevant drawings. It should be understood that the drawings described below are only used to illustrate some embodiments of the present application, and those skilled in the art can also obtain many other technical features and connection relationships not mentioned herein based on these drawings.

[0040] Figure 1 It is a flow chart of a method for monitoring eye movement and radiation dose in head and neck radiotherapy provided by an embodiment of the present application.

[0041] Figure 2 This is another flow chart of the method for monitoring eye movement and radiation dose in head and neck radiotherapy provided by the embodiment of the present application.

[0042] Figure 3 Schematic diagram of the structure of the device for monitoring eye movement and radiation dose in head and neck radiotherapy provided in an embodiment of the present application.

[0043] Figure 4 A schematic diagram of the area division under a CT image during the radiotherapy process using the method for eye movement monitoring and radiation dose monitoring in head and neck radiotherapy provided by the embodiment of the application.

[0044] Figure 5 A schematic diagram of another area division under a CT image during the radiotherapy process using the method for eye movement monitoring and radiation dose monitoring in head and neck radiotherapy provided by the embodiment of the application.

[0045] Figure 6 A schematic diagram of another area division under a CT image during the radiotherapy process using the method for eye movement monitoring and radiation dose monitoring in head and neck radiotherapy provided by the embodiment of the application.

[0046] Figure 7 A three-dimensional schematic diagram of an eye movement monitoring and radiation dose monitoring device and a radiotherapy device for head and neck radiotherapy according to an embodiment of the present application.

[0047] Description of reference numerals:

[0048] 2. Radiotherapy bed;

[0049] 31. Eye monitoring device; 32. Controller; 33. Radiotherapy equipment;

[0050] 41. Fixing mechanism; 42. Support arm; 43. Clamping claw;

[0051] 51. Eyeball; 52. Lens; 53. Cornea.

[0052] 61. First area; 62. Second area;

[0053] 71. First sub-area; 72. Second sub-area. DETAILED DESCRIPTION

[0054] The inventors of this application discovered that due to involuntary or unconscious eye movements, sensitive parts of the eye (such as the lens and cornea) may be misdirected from their originally safe, low-dose area to the adjacent high-dose radiation treatment area. Existing technology makes it impossible to monitor the duration of radiation exposure in real time.

[0055] To this end, the present application provides a method, storage medium, and monitoring device for monitoring eye movement and radiation dose during head and neck radiotherapy. The specific implementation methods of the present application will be described in detail below with reference to the accompanying drawings.

[0056] Implementation Method 1

[0057] The first embodiment of the present application provides a method for monitoring eye movement and radiation dose during head and neck radiotherapy. Figure 1 As shown, Figure 1 This is a flow chart of a method for monitoring eye movement and radiation dose during head and neck radiotherapy provided by an embodiment of the present application. This monitoring method includes the following steps:

[0058] S1. See Figure 5 As shown, the human body is divided into at least two regions using an isodose curve, and the at least two regions include a first region 61 and a second region 62, wherein the radiation dose received by the first region 61 per unit time is higher than the radiation dose received by the second region 62;

[0059] During radiotherapy, the target area of ​​the tumor is usually framed and a high dose of radiation is irradiated to this target area. For ease of understanding, it can be simplified to think that the area within the target area is the first area 61 mentioned in this application, and the area outside the target area is the second area 62. Of course, for different radiation equipment, the radiation is not evenly distributed whether it is within the target area or outside the target area, so the specific division of the first area 61 and the second area 62 can be determined according to actual conditions. In short, in the scheme of the present application, the first area 61 is mainly the range area where the radiation dose (or cumulative radiation dose) has an impact on the patient's eye 51 and the impact is unbearable, and the second area 62 is mainly a safe area, that is, the radiation dose of the radiation has no effect on the patient's eye 51 or the impact is tolerable.

[0060] To better understand the solution of the embodiment of the present application, please refer to Figure 5 and Figure 6 ,in, Figure 5 A schematic diagram of the division of regions on a CT image during radiotherapy using the method for monitoring eye movement and radiation dose in head and neck radiotherapy provided by embodiment 1 of the application is provided. Figure 6 This is another schematic diagram of divided areas on a CT image during radiotherapy using the method for eye movement monitoring and radiation dose monitoring during head and neck radiotherapy provided by embodiment 1 of the application.

[0061] S2 . Monitor the patient's eye movements and count the time the dose-sensitive portion of the patient's eye 51 stays in the first area 61 .

[0062] like Figure 5 As shown, in the positioning CT image used during the patient's radiotherapy, the area corresponding to the eyeball 51, lens, and cornea can be mapped and then selected with a line frame. In other words, in the radiotherapy positioning CT image, the patient's eyeball can be monitored in real time using an artificial intelligence-based image recognition algorithm.

[0063] In addition, see Figure 7 As shown, in the embodiment of the present application, the movement of the eyeball can also be identified with the help of an eyeball monitoring device 31. In the prior art, many devices for monitoring eyeball movement have appeared. The principle is generally that when a person's eyes look in different directions, there will be subtle changes in the eyes. These changes will produce extractable features, and the computer can extract these features through image capture or scanning, thereby tracking and monitoring eyeball changes in real time. Taking the Chinese invention patents with application numbers CN201910737436.1, "CN201710694351.0" and "CN201910228121.4" as examples, they monitor eyeball movement through three methods: infrared sensing, light tracking, and image recognition.

[0064] For example, in the VR field, it is also common to use eye movement monitoring to achieve interaction between programs and operators.

[0065] Based on the principles of the above devices, combined with CT images for radiotherapy positioning, it is very easy to determine whether the sensitive area falls within the first area 61.

[0066] Similarly, since the first region 61 and the second region 62 are also demarcated, the technical solution of the present application can consider the distance between the dose-sensitive portion of the eye 51 and the tumor target, primarily including the distance between the radiation-dose-sensitive lens 52 and cornea 53 and the tumor target. In CT images, the distance between the sensitive portion of the eye and the tumor target can be determined simply by comparison.

[0067] In this application, the dose-sensitive areas of the patient's eye are preferably the lens 52 and cornea 53 of the eye 51. The lens 52 and cornea 53 are the most sensitive to radiation dose and are also the most difficult to repair. Focusing on these two areas can better prevent additional radiation-induced visual damage.

[0068] The unit time mentioned in step S1 of the embodiment of the present application can be set according to the size of the radiation dose and in combination with actual needs. For example, the unit time can be pre-set to between 0.5s and 2s. Generally speaking, under high-dose radiation exposure, a cumulative time of more than 4s-5s may cause permanent damage to sensitive parts, and the damage of radiation can accumulate over time, so it is not recommended that the unit time exceed 2s.

[0069] It is easy to understand that for many patients, especially children and elderly patients, the movement of the eyeball 51 is difficult to control for a long time. Therefore, in the process of real-time monitoring of the patient's eyeball 51, the monitored movements are mainly involuntary or unconscious rotations. The position changes of the sensitive parts of the eyeball 51 caused by these movements are irregular. Once the sensitive parts stay in the first area 61 for a long time, it is easy to cause serious radiation damage. The present application can facilitate the understanding of the possible impact of radiation on the eyeball 51 by real-time monitoring of the time that the sensitive parts are in the first area 61.

[0070] For example, by real-time monitoring of the duration of radiation exposure to the eyeball 51, the cumulative and specific duration of radiation exposure to the sensitive area in the first region 61 can be determined. During radiation therapy, the physician can promptly remind and guide the patient's gaze to avoid high-dose areas. Specifically, the patient can be instructed to clearly indicate the direction of gaze, or guidance objects, such as screens or markers, can be used to guide the patient's eyeball 51 toward a safe area.

[0071] Furthermore, in this statistical step, the radiation dose received by the sensitive portion of the patient's eye 51 can be converted based on parameters such as the duration of time the dose-sensitive portion of the patient's eyeball 51 remains in the first region 61 and the volume of overlap between the sensitive portion and the first region 61 during exposure. Generally speaking, a cumulative radiation dose of 1000 cGy to a sensitive portion can cause permanent damage to sensitive areas such as the lens and cornea. Obviously, dose is more intuitive than duration. By collecting data, the correlation between the impact of the additional radiation dose received by the lens 52 and cornea 53 due to malfunction of the eyeball 51 on the patient's visual function prognosis can be evaluated to facilitate subsequent treatment.

[0072] Implementation Method 2

[0073] It is easy to understand that the higher the data accuracy of the irradiated dose obtained for the lens 52 and the cornea 53, the higher the accuracy of the data analysis.

[0074] In view of this, the second embodiment of the present application also provides a method for monitoring eye movement and radiation dose during head and neck radiotherapy, which can improve the accuracy of the radiation dose to dose-sensitive areas. Figure 6 As shown, it includes:

[0075] In the first area 61, it is further divided into multiple sub-areas by dose division lines, and the average radiation dose intensity per unit volume of each sub-area is calculated; then, in the statistical step, the radiation dose received by the sensitive part in each sub-area is counted and summed up to obtain the radiation dose received by the sensitive part.

[0076] exist Figure 5 and Figure 6 , especially in Figure 6 In the figure, the first area 61 is divided into many sub-areas, and the multiple sub-areas include at least a first sub-area 71 and a second sub-area 72. The first sub-area 71 and the second sub-area 72 are located between the two eyeballs 51 of the patient, and the shapes of the first sub-area 71 and the second sub-area 72 are designed according to the shape of the tumor and avoid the sensitive parts of the patient's eyeball 51.

[0077] It can be understood that a dose segmentation line is similar to a contour line, meaning that the dose per unit time is equal at all points along the line. The shape of the dose segmentation line is often irregular. This is because the radiation pattern must be adjusted according to the shape of the tumor, which also often has an irregular growth pattern. In addition, sensitive areas must be avoided.

[0078] In the embodiment of the present application, each sub-region is designed based on the shape of the tumor and avoidance of sensitive areas, ensuring the data accuracy of the statistical exposure dose. In this case, the radiation dose of each sub-region can be calculated in a method similar to calculus, and then the radiation dose received by each sub-region is summed up, which effectively improves the data accuracy.

[0079] Implementation Method 3

[0080] Considering that during the manual notification process, the doctor needs to pay attention to the patient's eyeball 51 movement in real time, which is a heavy workload, the automation level of dose monitoring is further improved in this application.

[0081] In view of this, see Figure 4 The third embodiment of the present application also provides a method for monitoring eye movement and radiation dose during head and neck radiotherapy, which further includes:

[0082] When the sensitive part stays in the first area 61 and meets the first preset condition, an alarm prompt is issued;

[0083] The first preset condition includes but is not limited to one of the following preset conditions or any combination thereof:

[0084] The sensitive part stays in the first area 61 for a time period exceeding a first preset time period;

[0085] The radiation dose received by the sensitive part during a single stay in the first area 61 exceeds the first preset dose;

[0086] The cumulative radiation dose received by the sensitive part while staying in the first area 61 exceeds the second preset dose.

[0087] Taking into account the need to stabilize the patient's mentality, alarm prompts can be displayed on the display screen during radiotherapy, or by making specific icons / areas on the screen flash and change color, without making any sound.

[0088] In the above scheme, due to factors such as different conditions, ages, and physical conditions of patients, the intensity and duration of radioactivity during surgery are different for each patient. Therefore, the first preset duration, the first preset dose, and the second preset dose can be set according to actual conditions.

[0089] It can be understood that the first area 61 is the area where the eyeball 51 is affected by radiation. For sensitive parts of the eyeball 51, the longer the time spent in the first area 61, the more likely the eyeball 51 will suffer from early and late visual damage such as conjunctivitis, scleral hemorrhage, keratitis, cataracts, glaucoma, panophthalmitis and even blindness, and radiation visual damage is often irreversible.

[0090] Although the first area 61 is a non-safe area, the impact on the sensitive parts of the eye 51 is acceptable, provided that the time spent in the first area 61 is extremely short and the radiation dose is low. That is, the first preset condition includes a first preset duration. By comparing the time the sensitive part spends in the first area 61 with the first preset duration, if the duration exceeds this, it indicates a risk to the sensitive part, and an alarm is issued.

[0091] The principle behind using a single radiation dose as an alarm indicator is the same as that of using dwell time, and will not be elaborated upon. Compared to calculating dwell time, calculating dose is more accurate. It is understandable that even if a single dwell time is short, multiple dwell times can result in a long cumulative time, leading to excessive cumulative radiation dose and potential damage to sensitive areas. Therefore, this embodiment also uses cumulative radiation dose as an alarm indicator.

[0092] This embodiment provides an alarm prompt through automatic equipment, which simplifies the doctor's operation and reduces labor costs.

[0093] As a further improvement of the embodiment of this application, see Figure 2 As shown, the monitoring method further includes S3: when the sensitive part stays in the first area 61 and meets the second preset condition, suspending the radiation irradiation;

[0094] The second preset condition includes one or any combination of the following preset conditions:

[0095] The sensitive part stays in the first area 61 for a time period exceeding a second preset time period;

[0096] The radiation dose received by the sensitive part during a single stay in the first area 61 exceeds the third preset dose;

[0097] The cumulative radiation dose received by the sensitive portion while staying in the first region 61 exceeds the fourth preset dose.

[0098] Similarly, the second preset duration, third preset dose, and fourth preset dose can be set according to actual circumstances. It is worth noting that the second preset duration can be the same as or different from the first preset duration. The third preset dose can be the same as or different from the first preset dose. The fourth preset dose can also be the same as or different from the second preset dose.

[0099] It should be noted that the severity of the triggering condition can be slightly lower than that of the second condition. In other words, the radiation dose to the sensitive area under the first condition can be lower than that under the second condition. This allows for an alert-then-pause process, avoiding repeated pauses that could affect treatment progress.

[0100] In addition, in the embodiments of the present disclosure, refer to Figure 2 , Figure 2 This is another flow chart of the method for monitoring eye movement and radiation dose in head and neck radiotherapy provided in embodiment 2 of the present application. The method further includes:

[0101] S4. When the sensitive part leaves the first area 61 and returns to the second area 62 and the third preset condition is met, the radiation irradiation is continued;

[0102] The third precondition includes one or any combination of the following preconditions:

[0103] The sensitive part completely leaves the first area 61 for a period exceeding a third preset time period;

[0104] The cumulative radiation dose received by the sensitive part while staying in the first area 61 is lower than the fifth preset dose.

[0105] When the sensitive portion returns from the first area 61 to the second area 62, it indicates that the sensitive portion has moved from the non-safe area to the safe area. However, although the sensitive portion is in a relatively safe area, the movement of the patient's eyeball 51 may not stop immediately and may return to the first area 61 at any time. To ensure safety, in this embodiment, a third preset time period is counted for the sensitive portion to have been away from the first area 61. When the third preset time period is exceeded, it indicates that the movement of the patient's eyeball 51 has stabilized and radiation exposure can be continued.

[0106] The cumulative radiation dose to sensitive areas is consistently calculated. When the cumulative radiation dose received during the stay in the first region 61 is lower than the fifth preset dose, it indicates that the radiation dose to the sensitive areas is low and it is safe to continue irradiation. It is understood that the fifth preset dose, the fourth preset dose, and the second preset dose can be the same or different. Preferably, the second preset dose is less than the fourth preset dose, and the fourth preset dose is equal to the fifth preset dose.

[0107] It is understandable that by automatically stopping irradiation in an emergency and resuming irradiation after the emergency is cancelled, the equipment can achieve unattended radiotherapy operations compared to simply giving an alarm prompt, so it has a higher degree of automation and lower costs.

[0108] Furthermore, it should be emphasized that although the various embodiments of the present application are primarily described using the first region 61 and the second region 62 as examples, it is understandable that the at least two regions may also be the first region 61, the second region 62, the third region, and so on, the Nth region. The Nth region is a safe area, and the radiation doses of the first region 61, the second region 62, and so on, the N-1th region, are all greater than those of the Nth region. N may be a positive integer greater than or equal to 3.

[0109] When it is the first area 61, the second area 62, the third area...the Nth area, the Nth area is a safe area. In step S3, when the sensitive part leaves the first area 61 or the second area 62 or the third area...or the N-1th area and returns to the Nth area, and meets the third preset condition, the radiation irradiation continues.

[0110] For ease of understanding, this application takes a patient with a tumor near the eyeball as an example, and the steps of treatment according to the embodiment of this application are as follows:

[0111] Step 1) In the positioning CT image used during the patient's radiotherapy, based on the distribution of tumor cells, the sensitive parts of the eyeball 51, that is, the areas corresponding to the lens 52 and the cornea 53, are mapped, and a first area 61 can be obtained by selecting a line frame;

[0112] Step 2), dividing the first area 61 into multiple sub-areas;

[0113] Step 3) Monitor the patient's eye movements and calculate the duration that the dose-sensitive portion of the patient's eye 51 remains in the sub-region. The radiation dose received by the dose-sensitive portion of the patient's eye is calculated based on the duration that the dose-sensitive portion of the patient's eye remains in the sub-region and the overlap volume of the sensitive portion with the first region during the exposure period, thereby facilitating guidance of the patient's eye based on the radiation dose and protecting the sensitive portion of the patient's eye 51.

[0114] Step 4) When the sensitive part of the patient stays in the first area 61 and meets the first preset condition, an alarm is issued;

[0115] Alternatively, when the sensitive part of the patient stays in the first area 61 and meets the second preset condition, suspending the radiation irradiation;

[0116] Alternatively, when the sensitive part of the patient leaves the first area 61 and returns to the second area 62, and the third preset condition is met, the radiation irradiation continues; this facilitates the evaluation of the data correlation of the impact of the additional exposure dose to the lens 52 and cornea 53 due to the mismovement of the eyeball 51 on the patient's prognosis of visual function, so as to facilitate the subsequent treatment.

[0117] The above content details the steps and effects of the monitoring method, and the method also has a wider range of application scenarios. For example, a larger number of patients can be selected to enroll in the group to expand the basic database of the model, and the obtained eye movement data can be associated with the dose data of the radiotherapy planning system to establish a generalizable mathematical model for the positioning and protection of the eyeball 51 during radiotherapy. This model can be used to form a complete set of new strategies for the precise positioning and protection of the eyeball 51 during radiotherapy, from precise positioning and precise control to precise treatment. This type of dynamic monitoring data model can be applied to more clinical fields.

[0118] Implementation Method 4

[0119] A computer-readable storage medium stores a computer program. When the computer program is executed by a processor, the monitoring method of the first embodiment can be implemented.

[0120] It should be noted that the computer-readable storage medium may be the computer-readable storage medium included in the above-mentioned embodiment, or it may be a separate computer-readable storage medium not incorporated into the device. The computer-readable storage medium stores one or more programs, which are used by one or more processors to execute the method described in the first embodiment of the present invention.

[0121] According to an embodiment of the present application, the readable storage medium can be a computer-readable signal medium or a computer-readable storage medium or any combination of the above two. The computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of computer-readable storage media can include, but are not limited to: an electrical connection with one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above.

[0122] Implementation Method Five

[0123] In order to understand the application scenarios of this application and the devices used in the relevant implementation methods, please refer to Figure 3 and Figure 7 The fifth embodiment of the present application provides a device for monitoring eye movement and radiation dose during head and neck radiotherapy, the monitoring device comprising:

[0124] an eye monitoring device 31 for monitoring the patient's eye 51 movements;

[0125] The controller 32 is in communication with the radiotherapy device 33 and is used to:

[0126] See also Figure 5 As shown, on the CT scan image, the human body is divided into at least two regions using a dose dividing line according to the dose per unit time of radiation acting on the human body. The at least two regions include a first region 61 and a second region 62, wherein the radiation dose received by the first region 61 per unit time is higher than that received by the second region 62;

[0127] The controller 32 counts the time that the dose-sensitive part of the patient's eye 51 stays in the first area 61 according to the movement of the eye 51 fed back by the eye monitoring device 31 .

[0128] On the CT scan image, the human body is divided into at least two regions using a dose dividing line according to the dose of radiation acting on the human body per unit time. The at least two regions include a first region 61 and a second region 62, wherein the radiation dose received by the first region 61 per unit time is higher than that received by the second region 62.

[0129] When the eye monitoring device 31 is used to monitor the movement of the patient's eyeball 51 in real time, in the radiotherapy positioning CT image, slight movements of the patient's eyeball will be reflected in the CT image. Combined with the image comparison and recognition in the existing technology, the eye monitoring device 31 can realize real-time monitoring of the patient's eyeball.

[0130] When the eye 51 moves, it can be monitored by the eye monitoring device 31. The dose-demarcation line divides the human body into at least two zones, with the second zone 62 serving as the safe zone. This zone is compared with the first zone 61 to determine whether the eye 51 is within the safe zone. The controller 32 measures the duration that the dose-sensitive portion of the patient's eye 51 remains in the first zone 61, enabling real-time monitoring of the duration of radiation exposure to the eye 51.

[0131] In the above scheme, the dose per unit time of radiation acting on the human body can be obtained through CT scan images.

[0132] The step of calculating the length of time the dose-sensitive part of the patient's eye 51 stays in the first area 61 also includes: converting the radiation dose received by the sensitive part according to the length of time the dose-sensitive part of the patient's eye 51 stays in the first area 61 and the size of the overlapping volume between the sensitive part and the first area 61 during the exposure period.

[0133] As a further solution of the embodiment of the present disclosure, the first area 61 is further divided into multiple sub-areas by dose division lines, and the average radiation dose intensity per unit volume of each sub-area is calculated. In the statistical step, the radiation dose received by the sensitive parts in each sub-area is counted and summed up.

[0134] As a further solution of the embodiment of the present disclosure, it also includes:

[0135] When the sensitive part stays in the first area 61 and meets the first preset condition, an alarm prompt is issued;

[0136] The first preset condition includes one or any combination of the following preset conditions:

[0137] The sensitive part stays in the first area 61 for a time period exceeding a first preset time period;

[0138] The radiation dose received by the sensitive part during a single stay in the first area 61 exceeds the first preset dose;

[0139] The cumulative radiation dose received by the sensitive part while staying in the first area 61 exceeds the second preset dose.

[0140] As a further solution of the embodiment of the present disclosure, it also includes:

[0141] When the sensitive part stays in the first area 61 and meets the second preset condition, suspending the radiation irradiation;

[0142] The second preset condition includes one or any combination of the following preset conditions:

[0143] The sensitive part stays in the first area 61 for a time period exceeding a second preset time period;

[0144] The radiation dose received by the sensitive part during a single stay in the first area 61 exceeds the third preset dose;

[0145] The cumulative radiation dose received by the sensitive portion while staying in the first region 61 exceeds the fourth preset dose.

[0146] The method further includes: when the sensitive part leaves the first area 61 and returns to the second area 62 and a third preset condition is met, continuing the radiation irradiation;

[0147] The third precondition includes one or any combination of the following preconditions:

[0148] The sensitive part completely leaves the first area 61 for a period exceeding a third preset time period;

[0149] The cumulative radiation dose received by the sensitive part while staying in the first area 61 is lower than the fifth preset dose.

[0150] Preferably, the sensitive parts are the lens 52 and cornea 53 of the eyeball 51 .

[0151] In actual use, the installation position of the eye monitoring device 31 is very important for monitoring the patient's eye 51. In the solution of the embodiment of the present disclosure, preferably, the eye monitoring device 31 is installed on the radiotherapy bed 2 and is located diagonally above the position of the patient's head when lying down. Being installed there can also prevent the eye monitoring device 31 and its supporting structure from blocking the radiation.

[0152] In order to better illustrate the application scheme of the embodiment of the present disclosure, please refer to Figure 7 , Figure 7 A three-dimensional schematic diagram of the eye movement monitoring and radiation dose monitoring device and radiotherapy equipment during head and neck radiotherapy provided in an embodiment of the present application, wherein the eye monitoring device 31 can be installed at one end of a fixing mechanism 41, and the side of the fixing mechanism 41 away from the eye monitoring device 31 is fixedly connected to one end of a support arm 42, and the other end of the support arm 42 is connected to a clamping claw 43.

[0153] The clamping claw 43 can be a conventional spring clamp, secured to the radiotherapy bed 2 by the elastic force of a spring. By adjusting the area clamped by the clamping claw 43, the area currently irradiated by the radiation generating device 1 can be effectively avoided. Of course, bolts can also be used to tighten the clamping claw 43.

[0154] It should be noted that, see Figure 7 The controller 32 is mainly located inside the radiotherapy equipment 33, but in actual use, the controller 32 can also be separately set in other external equipment.

[0155] Radiotherapy is performed on the patient using radiotherapy equipment 33. The movement of the eye 51 can be monitored by the eye monitoring device 31, enabling real-time monitoring of the duration of radiation exposure. The controller 32 measures the duration that the dose-sensitive portion of the patient's eye 51 remains within the first region 61, facilitating medical personnel's assessment of the patient's eye status and guiding the patient's gaze away from high-dose areas as needed.

[0156] Finally, it should be noted that those skilled in the art will appreciate that, in order to facilitate a better understanding of this application, the embodiments of this application set forth numerous technical details. However, even without these technical details and the various variations and modifications based on the above-described embodiments, the technical solutions claimed in the claims of this application can be substantially achieved. Therefore, in actual practice, various modifications may be made to the above-described embodiments in form and detail without departing from the spirit and scope of this application.

Claims

1. A computer program product comprising a computer program, characterized in that When executed, the computer program can implement a method for monitoring eye movement and radiation dose during head and neck radiotherapy, the method comprising: Dividing a human body into at least two regions using an isodose curve, the at least two regions comprising a first region and a second region, wherein the radiation dose received by the first region per unit time is higher than that received by the second region; monitoring the patient's eye movements and counting the time the dose-sensitive portion of the patient's eye remains in the first area; When the sensitive part stays in the first area and meets a second preset condition, suspending the radiation irradiation; when the sensitive part leaves the first area and returns to the second area and meets a third preset condition, continuing the radiation irradiation; The second preset condition includes one or any combination of the following preset conditions: The sensitive part stays in the first area for a period exceeding a second preset period; The radiation dose received by the sensitive part during a single stay in the first area exceeds a third preset dose; The cumulative radiation dose received by the sensitive part while staying in the first area exceeds a fourth preset dose; The third preset condition includes one or any combination of the following preset conditions: The sensitive part completely leaves the first area, and the duration exceeds a third preset time; The cumulative radiation dose received by the sensitive part while staying in the first area is lower than a fifth preset dose.

2. The computer program product according to claim 1, wherein The statistical step also includes: The radiation dose received by the dose-sensitive part of the patient's eyeball is converted according to the length of time the dose-sensitive part of the patient's eyeball stays in the first area and the overlapping volume of the sensitive part with the first area during the exposure period.

3. The computer program product according to claim 2, wherein The first region is further divided into a plurality of sub-regions by a dose segmentation line, and the average radiation dose intensity per unit volume of each sub-region is calculated; In the statistical step, the radiation dose received by the sensitive part in each sub-region is counted and summed up.

4. The computer program product according to any one of claims 1 to 3, characterized in that Also includes: When the sensitive part stays in the first area and meets a first preset condition, an alarm prompt is issued; The first preset condition includes one or any combination of the following preset conditions: The sensitive part stays in the first area for a period exceeding a first preset period; The radiation dose received by the sensitive part during a single stay in the first area exceeds a first preset dose; The cumulative radiation dose received by the sensitive part while staying in the first area exceeds a second preset dose; The second preset dose is smaller than the fourth preset dose.

5. The computer program product according to claim 1, wherein The sensitive parts are the lens and cornea of ​​the eyeball.

6. The computer program product according to claim 1, wherein The computer program product is a readable storage medium.

7. A device for monitoring eye movement and radiation dose during head and neck radiotherapy, characterized in that: include: An eye monitoring device for monitoring the patient's eye movements; A controller is communicatively connected to the radiotherapy device, and is configured to: Obtaining a dose per unit time of radiation acting on a human body, dividing the human body into at least two regions using a dose dividing line, the at least two regions comprising a first region and a second region, wherein the radiation dose per unit time received by the first region is higher than that received by the second region; The controller calculates the time that the dose-sensitive part of the patient's eyeball stays in the first area according to the eyeball movement fed back by the eyeball monitoring device; When the sensitive part stays in the first area and meets a second preset condition, suspending the radiation irradiation; when the sensitive part leaves the first area and returns to the second area and meets a third preset condition, continuing the radiation irradiation; The second preset condition includes one or any combination of the following preset conditions: The sensitive part stays in the first area for a period exceeding a second preset period; The radiation dose received by the sensitive part during a single stay in the first area exceeds a third preset dose; The cumulative radiation dose received by the sensitive part while staying in the first area exceeds a fourth preset dose; The third preset condition includes one or any combination of the following preset conditions: The sensitive part completely leaves the first area, and the duration exceeds a third preset time; The cumulative radiation dose received by the sensitive part while staying in the first area is lower than a fifth preset dose.

8. The device for monitoring eye movement and radiation dose during head and neck radiotherapy according to claim 7, characterized in that: The eyeball monitoring device is installed on the radiotherapy bed and is located obliquely above the position where the patient's head is located when the patient lies down.

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