A fluorescence chromatography immunoassay component and a dual-channel immunoassay analyzer

Abstract

This invention discloses a fluorescence chromatography-immunoassay (LCIA) component and a dual-channel immunoassay analyzer. The LCIA component includes a mounting frame and a detection and analysis mainboard mounted on the mounting frame for sample detection and analysis. It also includes a card holder, an optical detection component, a first driving mechanism, and a second driving mechanism. The card holder and the optical detection component are slidably mounted on the mounting frame. The first driving mechanism is connected to the card holder and drives the card holder to move on the mounting frame; the card holder is used to hold test cards. The optical detection component is connected to and slidably mounted on the mounting frame through the second driving mechanism, which drives the optical detection component to move. The moving direction of the optical detection component is opposite to the moving direction of the card holder. The detection and analysis mainboard is connected to the optical detection component. In practical use, this invention can achieve the determination of multiple sets of data, offering the advantage of high detection efficiency.

Description

Technical Field

[0001] This invention relates to the field of blood gas analysis technology, specifically to a fluorescence chromatography immunoassay component; furthermore, this invention also relates to a dual-channel immunoassay analyzer. Background Technology

[0002] With the rapid development of society and economy, fluorescence immunoassay analyzers are instruments used to measure bioactive compounds in very low concentrations. Based on the principle of antigen-antibody reaction, known antigens or antibodies are first labeled with fluorescent groups, and then the fluorescent antibody (or antigen) is used as a probe to check the corresponding antigen (or antibody) in cells or tissues. After a laser is projected onto the sample area, the fluorescence is emitted to the sensor for data collection.

[0003] Currently, most existing fluorescence chromatography-immunoassay analyzers analyze samples on test cards by using a single test card as the primary analyzer. When multiple data points need to be tested, test cards must be frequently inserted and replaced, making it inconvenient to test multiple data points at once and reducing detection efficiency. Summary of the Invention

[0004] The purpose of this invention is to provide a fluorescence chromatography immunoassay component that can measure multiple sets of data in practical applications and has the advantage of high detection efficiency. At the same time, this invention also provides a dual-channel immunoassay analyzer that can simultaneously perform blood gas analysis and fluorescence chromatography immunoassay, thereby improving the applicability of the device.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows:

[0006] A fluorescence chromatography immunoassay kit includes a mounting frame and a detection and analysis mainboard mounted on the mounting frame for detecting and analyzing samples. The invention also includes a card holder, an optical detection component, a first driving mechanism, and a second driving mechanism. The card holder and the optical detection component are slidably mounted on the mounting frame.

[0007] The first drive mechanism is connected to the card holder and is used to drive the card holder to move on the mounting frame. The card holder is used to install test cards. The optical detection component is connected to the second drive mechanism and is slidably mounted on the mounting frame through the second drive mechanism. The second drive mechanism is used to drive the optical detection component to move.

[0008] The optical detection component moves in the opposite direction to the card tray, and the detection and analysis motherboard is connected to the optical detection component.

[0009] The card holder is provided with a guide groove, and a first guide rail and a second guide rail are provided in the guide groove, forming a first sliding area between the first guide rail and the second guide rail;

[0010] Test cards include single-piece test cards, triple-piece test cards, and five-piece test cards. The triple-piece test cards and five-piece test cards are provided with a first guide groove and a second guide groove that correspond to the first guide rail and the second guide rail, respectively.

[0011] The two side walls of the guide groove form a limiting part to limit the five-piece test card; the distance between the first and second guide rails matches the distance of the single-piece test card, and the distance between the two side walls of the guide groove matches the distance of the five-piece test card.

[0012] Further optimization involves providing a notch on the second guide rail, within which an elastic portion is provided. This elastic portion is used to contact the side wall of the single-unit test card or the side wall of the second guide groove of the triple-unit or five-unit test card.

[0013] The card holder is slidably mounted on the mounting bracket via a sliding assembly;

[0014] The first drive mechanism includes a first motor, a first U-shaped bracket, a first lead screw, and a first nut. The first U-shaped bracket is mounted on the mounting bracket, the first lead screw is rotatably mounted on the first U-shaped bracket, the first motor is mounted on the first U-shaped bracket and connected to the first lead screw, and the first nut is engaged with the first lead screw and connected to the card holder.

[0015] The card holder has a connecting part on its side, and the connecting part has a mounting groove and a relief groove communicating with the mounting groove. After the first nut is engaged in the relief groove, the first lead screw passes through the relief groove.

[0016] Further optimized, the second drive mechanism includes a second motor, a second U-shaped bracket, a second lead screw, a second nut, and a mounting base. The mounting base is slidably mounted on the mounting frame via a second slider and a second slide rail. The second U-shaped bracket is mounted on the mounting frame. The second lead screw is rotatably mounted on the second U-shaped bracket and then connected to the second motor. The mounting base is provided with a mounting plate for mounting the optical detection component. The mounting base is provided with a slot and a second clearance slot. The slot and the second clearance slot are connected. The second nut is engaged in the slot and then cooperates with the lead screw. The lead screw passes through the second clearance slot.

[0017] The optical detection component includes a housing, within which a laser channel and a refraction channel are arranged, connected to each other. A light source assembly is located within the laser channel, and a dichroic beam-splitting filter is located within the refraction channel. A plano-convex cylindrical mirror is also located within the refraction channel, positioned below the dichroic beam-splitting filter. A light-transmitting aperture communicating with the refraction channel is provided on the housing. A rear sensor is mounted on the housing, located within the refraction channel and above the dichroic beam-splitting filter. The plane of the plano-convex cylindrical mirror faces the light-transmitting aperture. The housing is connected to a second drive mechanism, and the sensor is connected to a detection and analysis mainboard.

[0018] To further specify, a positive meniscus lens is placed between the dichroic beam-splitting filter and the sensor within the refraction channel.

[0019] The outer shell includes a left outer shell and a right outer shell. Each of the left and right outer shells includes an integral horizontal part and a vertical part. The horizontal part and the vertical part are connected to form an L-shaped structure. A horizontal groove is provided on the horizontal part and a vertical groove is provided on the vertical part. After the left and right shells are connected together, the horizontal groove forms the laser channel and the vertical groove forms the refraction channel. A notch is provided at the lower end of the vertical part, and the notch forms a light-transmitting hole. The dichroic beam-splitting filter, the plano-convex cylindrical mirror and the positive meniscus lens are all installed in the vertical groove of the vertical part, and the light source assembly is installed in the horizontal groove.

[0020] Further optimization includes a first protrusion and a second protrusion within the vertical groove, both of which are semi-circular arc structures, forming a positive meniscus lens mounting groove between them; a first slot and a second slot are provided on the vertical part, both of which are connected to the vertical groove, and the angle between the line connecting the first and second slots and the horizontal plane is 135°, with the dichroic beam-splitting filter installed in the first and second slots; a semi-cylindrical groove is provided on the vertical part, connected to the vertical groove, with a plano-convex cylindrical mirror installed in the semi-cylindrical groove.

[0021] The left and right outer shells are connected by screws. The left outer shell has a positioning protrusion and the right outer shell has a positioning groove. After the left and right outer shells are connected, the positioning protrusion and the positioning groove engage.

[0022] This invention discloses a dual-channel immunoassay analyzer, comprising a frame, a fluorescence chromatography immunoassay component and a blood gas analysis component mounted on the frame, a main control board connected to the fluorescence chromatography immunoassay component and the blood gas analysis component is disposed inside the frame, a housing is disposed on the frame, the housing is mounted with a touch screen connected to the main control board, and the housing is provided with test card inlet / outlet ports corresponding to the fluorescence chromatography immunoassay component and the blood gas analysis component.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] This invention mainly consists of a detection and analysis motherboard, a card holder, an optical detection component, a first driving mechanism, and a second driving mechanism. In actual use, single or multiple test cards are installed on the card holder, and the test cards are delivered into the holder under the action of the first driving mechanism. When testing multiple test cards, the second driving mechanism drives the optical detection component to move, and the optical detection component sequentially detects the sample areas on the multiple test cards, enabling the determination of multiple sets of data on the multiple test cards, and has the advantage of high detection efficiency. Attached Figure Description

[0025] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained from these drawings without creative effort.

[0026] Figure 1 This is a schematic diagram of the overall structure of Embodiment 2 of the present invention.

[0027] Figure 2 For the present invention Figure 1 A schematic diagram of the overall structure after the shell has been removed.

[0028] Figure 3 This is a schematic diagram of the overall structure of the single-unit test card of the present invention.

[0029] Figure 4 This is one of the schematic diagrams of the overall structure of the triplet test card of the present invention.

[0030] Figure 5 This is the second schematic diagram of the overall structure of the three-piece test card of the present invention.

[0031] Figure 6 This is a schematic diagram of the overall structure of the five-connection test card of the present invention.

[0032] Figure 7 This is a schematic diagram of the overall structure of the card holder of the present invention.

[0033] Figure 8 This is a diagram showing the state of the card holder pressing the five test cards onto the card holder frame.

[0034] Figure 9 This is a schematic diagram of the overall structure of the card holder pressure plate of the present invention.

[0035] Figure 10 This is a schematic diagram of the overall structure of the first and second driving mechanisms of the present invention.

[0036] Figure 11 This is one of the schematic diagrams showing the connection relationship between the first driving mechanism and the card holder of the present invention.

[0037] Figure 12 This is the second schematic diagram showing the connection relationship between the first driving mechanism and the card holder of the present invention.

[0038] Figure 13 This is a schematic diagram showing the connection relationship between the second driving mechanism and the optical detection component of the present invention.

[0039] Figure 14 This is a schematic diagram showing the present invention installed on a mounting bracket.

[0040] Figure 15 This is a schematic diagram of the overall structure of the optical detection component of the present invention.

[0041] Figure 16 For the present invention Figure 15 A schematic diagram of the overall structure after removing the left outer shell.

[0042] Figure 17 For the present invention Figure 15 A schematic diagram of the overall structure after removing the right outer shell.

[0043] Figure 18 For the present invention Figure 16 The front view.

[0044] Figure label:

[0045] 1. Fluorescence chromatography immunoassay analyzer; 2. Blood gas analyzer; 3. Housing; 4. Test card inlet / outlet; 5. Touchscreen.

[0046] 101-Card holder, 102-Single test card, 103-Triple test card, 104-Five-piece test card, 105-Guide groove, 106-First guide rail, 107-Second guide rail, 108-First guide groove, 109-Second guide groove, 110-Notch, 111-Elastic part, 112-Clamping part, 113-First guide ramp, 114-Second guide ramp, 115-Triangular guide structure, 116-The Four guide ramps, 117-fifth guide ramp, 118-card holder pressure plate, 119-U-shaped groove, 120-lower pressing part, 121-first lower pressure plate, 122-second lower pressure plate, 123-guide plate, 124-first rectangular through groove, 125-second rectangular through groove, 126-third rectangular through groove, 127-fourth rectangular through groove, 128-fifth rectangular through groove, 129-third guide ramp, 130-mounting groove.

[0047] 201-Mounting bracket, 202-First drive mechanism, 203-First motor, 204-First U-shaped bracket, 205-First lead screw, 206-First nut, 207-Second drive mechanism, 208-Second slider, 209-Optical detection assembly, 210-Connecting part, 212-Leaning groove, 213-First slide rail, 214-First slider, 215-Second motor, 216-Second U-shaped bracket, 217-Second lead screw, 218-Second nut, 219-Mounting base, 220-Mounting plate, 221-Groove;

[0048] 301-Housing shell, 302-Laser channel, 303-Refractive channel, 304-Light source assembly, 305-Dichroic beam splitter filter, 306-Planar-convex cylindrical mirror, 307-Light transmission hole, 308-Sensor, 309-Left housing shell, 310-Right housing shell, 311-Horizontal part, 312-Vertical part, 313-Horizontal groove, 314-Vertical groove, 315-First protrusion, 316-Second protrusion, 317-Curved surface, 318-First slot, 319-Second slot, 320-Semi-cylindrical groove, 321-Positive meniscus lens. Detailed Implementation

[0049] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the embodiments of the invention. Therefore, the drawings and description are considered to be exemplary in nature and not restrictive.

[0050] In the description of the embodiments of the present invention, it should be understood that the terms "length", "vertical", "horizontal", "top", "bottom", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of the present invention.

[0051] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of embodiments of the present invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0052] In this embodiment of the invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a communication connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this embodiment of the invention according to the specific circumstances.

[0053] In embodiments of the present invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature being directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature being directly above or diagonally above the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0054] The following disclosure provides many different implementations or examples for carrying out different structures of the embodiments of the present invention. To simplify the disclosure of the embodiments of the present invention, specific examples of components and arrangements are described below. Of course, these are merely examples and are not intended to limit the embodiments of the present invention. Furthermore, reference numerals and / or reference letters may be repeated in different examples of the embodiments of the present invention; such repetition is for simplification and clarity and does not in itself indicate a relationship between the various implementations and / or arrangements discussed.

[0055] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0056] Example 1

[0057] See Figures 3-18 This embodiment discloses a fluorescence chromatography immunoassay assembly, including a mounting frame 201 and a detection and analysis main board mounted on the mounting frame 201 for detecting and analyzing samples. This embodiment also includes a card holder 101, an optical detection component 209, a first driving mechanism 202 and a second driving mechanism 207. The card holder 101 and the optical detection component 209 are both slidably disposed on the mounting frame 201.

[0058] The first drive mechanism 202 is connected to the card holder 101 and is used to drive the card holder 101 to move on the mounting frame 201. The card holder 101 is used to install test cards. The optical detection component 209 is connected to the second drive mechanism 207 and is slidably disposed on the mounting frame 201 through the second drive mechanism 207. The second drive mechanism 207 is used to drive the optical detection component 209 to move.

[0059] The optical detection component 209 moves in the opposite direction to the card tray 101, and the detection and analysis motherboard is connected to the optical detection component 209.

[0060] This invention mainly consists of a detection and analysis motherboard, a card holder 101, an optical detection component 209, a first driving mechanism 202, and a second driving mechanism 207. In actual use, single or multiple test cards are installed on the card holder 101, and the test cards are sent into the interior under the action of the first driving mechanism 202. At this time, when the multiple test cards are being tested, the second driving mechanism 207 drives the optical detection component 209 to move. The optical detection component 209 sequentially detects the sample areas on the multiple test cards, which can realize the determination of multiple sets of data on the multiple test cards and has the advantage of high detection efficiency.

[0061] In this embodiment, the overall structure of the card holder 101 is as follows:

[0062] The card holder 101 is provided with a guide groove 105, and a first guide rail 106 and a second guide rail 107 are provided in the guide groove 105, forming a first sliding area between the first guide rail 106 and the second guide rail 107; the test card includes a single test card 102, a triple test card 103 and a five-part test card 104.

[0063] The triple test card 103 and the five-piece test card 104 are provided with a first guide groove 108 and a second guide groove 109 corresponding to the first guide rail 106 and the second guide rail 107, respectively.

[0064] The two side walls of the guide groove 105 form a limiting part that limits the five-piece test card 104; the distance between the first and second guide rails matches the distance of the single test card 102, and the distance between the two side walls of the guide groove 105 matches the distance of the five-piece test card 104.

[0065] The card holder 101 is mainly used to install single-unit test cards 102, triple-unit test cards 103, and five-unit test cards 104. The five-unit test card 104 is installed via a guide groove 105 on the card holder 101. Simultaneously, the guide groove 105 is divided into left, center, and right areas by a first guide rail 106 and a second guide rail 107. The area formed between the first guide rail 106 and the second guide rail 107 is the first sliding area for the single-unit test card 102 to move, thus enabling the installation of the single-unit test card 102. Furthermore, since both the triple-unit test card 103 and the five-unit test card 104 are equipped with… The device has a first guide groove 108 and a second guide groove 109, which correspond to the first guide rail 106 and the second guide rail 107. Thus, the first and second guide grooves 105 and the first and second guide rails facilitate the installation of the triple test card 103 and the five-piece test card 104. Simultaneously, the sidewall of the guide groove 105 also serves to limit the movement of the five-piece test card 104. This invention, through improvements to the card holder 101 and the test card mechanism, achieves the purpose of installing single-piece test cards 102, triple-piece test cards 103, and five-piece test cards 104 on the card holder 101, thus meeting the installation requirements of multi-piece test cards.

[0066] Further optimization involves providing a notch 110 on the second guide rail 107, with an elastic portion 111 inside the notch 110. The elastic portion 111 is used to contact the side wall of the single test card 102 or the side wall of the second guide groove 109 of the triple test card 103 and the five-piece test card 104.

[0067] The elastic part 111 has a pressing part 112 on the side facing the first guide rail 106. The pressing part 112 has an arc-shaped structure. The elastic part 111 can press and fix the test card after it is installed on the card holder 101, thereby limiting the test card and preventing it from falling out.

[0068] Further optimization involves providing a first guide slope 113 on one side of the first and second guide rails. The first guide slope 113 can guide the single test card 102 when it is installed, making the installation smoother.

[0069] The guide groove 105 has a second guide slope 114 on both sides, which facilitates the guidance of the five-piece test card 104 when it is installed.

[0070] Among them, the adjacent side walls of the first guide groove 108 and the second guide groove 109 on the triple test card 103 intersect to form a triangular guide structure 115, and the other side wall of the first guide groove 108 and the second guide groove 109 is provided with a third guide slope 129.

[0071] In this way, when the triangular guide structure 115 formed at the bottom of the triplet test card 103 is inserted, the purpose of guidance and installation can be achieved simply by aligning the end of the triangular guide structure 115 with the first sliding area.

[0072] The first guide groove 108 and the second guide groove 109 on the five-piece test card 104 are provided with a fourth guide slope 116 and a fifth guide slope 117 on their side walls, which facilitates the installation of the five-piece test card 104.

[0073] Further optimization involves providing an installation groove 130 at the bottom of the guide groove 105, where a heating plate is installed; this facilitates the installation of the heating plate to heat the test card and ensure the testing process.

[0074] The card holder 101 is provided with a card holder pressure plate 118. The card holder pressure plate 118 is provided with a number of rectangular through slots for the detection components to check the sample positions on the test card, namely, a first rectangular through slot 124, a second rectangular through slot 125, a third rectangular through slot 126, a fourth rectangular through slot 127 and a fifth rectangular through slot 128. The second and fourth rectangular through slots are connected by a U-shaped slot 119. The card holder pressure plate 118 between the second and fourth rectangular through slots and the U-shaped slot 119 forms a pressing part 120. The pressing part 120 is bent in the middle and near the U-shaped slot 119. The card holder pressure plate 118 is provided with a first pressing plate 121 and a second pressing plate 122.

[0075] In this way, the first, second, third, fourth and fifth rectangular through slots facilitate the inspection of the sample positions on the test card by the detection component; at the same time, the card holder pressure plate 118 between the second and fourth rectangular through slots and the U-shaped groove 119 forms a pressing part 120. The middle part of the pressing part 120 and the position near the U-shaped groove 119 are bent to press and fix the test card. Meanwhile, the first pressing plate 121 and the second pressing plate 122 fix the triple test card 103 and the five-piece test card 104.

[0076] In actual use, the card holder plate 118 is made of metal sheet.

[0077] Further optimization involves providing a guide plate 123 on the card holder pressure plate 118. The guide plate 123 guides the top of the test card, facilitating its installation.

[0078] In this embodiment, the specific structures of the first and second driving mechanisms are as follows:

[0079] The card holder 101 is slidably mounted on the mounting bracket 201 via a sliding assembly;

[0080] The first drive mechanism 202 includes a first motor 203, a first U-shaped bracket 204, a first lead screw 205, and a first nut 206. The first U-shaped bracket 204 is mounted on the mounting bracket 201. The first lead screw 205 is rotatably mounted on the first U-shaped bracket 204. The first motor 203 is mounted on the first U-shaped bracket 204 and then connected to the first lead screw 205. The first nut 206 is engaged with the first lead screw 205 and then connected to the card holder 101.

[0081] The card holder 101 has a connecting part 210 on its side. The connecting part 210 has a mounting groove 130 and a relief groove 212 communicating with the mounting groove 130. After the first nut 206 is engaged in the relief groove 212, the first lead screw 205 passes through the relief groove 212.

[0082] The first driving mechanism 202 drives the card holder 101 to enter and exit the mounting frame, thereby bringing the test card into the mounting frame and allowing it to be detected by the optical detection component 209. Simultaneously, by mounting the optical detection component 209 on the second driving mechanism 207, the second driving mechanism 207 drives the optical detection component 209 to move laterally, i.e., perpendicular to the direction of movement of the card holder 101. This allows for adjustment of the position of the optical detection component 209. Thus, when the test card is a multi-unit test card, the second driving mechanism 207 can drive the optical detection component 209 to move sequentially to the sample area above the multi-unit test card for detection. In practical use, this invention achieves the driving of the card holder 101 and the optical detection component 209, facilitating the detection of multi-unit test cards.

[0083] Meanwhile, the first drive mechanism 202 is a lead screw drive mechanism, which can be more stable when driving the card holder 101 to move. At the same time, the mounting groove 130 and the clearance groove 212 provided on the connecting part 210 of the card holder 101 can make it more convenient to install nuts and improve installation efficiency.

[0084] The sliding assembly includes a first slide rail 213 and a first slider 214. The first slide rail 213 is used to be mounted on the mounting bracket 201, and the first slider 214 is fixedly mounted on the card holder 101 and slidably connected to the first slide rail 213.

[0085] Further optimization involves the first slide rail 213 having a T-shaped or dovetail-shaped structure, and the first slider 214 matching the first slide rail 213; this improves the stability of the card holder 101 during movement.

[0086] The second drive mechanism 207 includes a second motor 215, a second U-shaped bracket 216, a second lead screw 217, a second nut 218, and a mounting base 219. The mounting base 219 is slidably mounted on the mounting frame 201 via a second slider 208 and a second slide rail. The second U-shaped bracket 216 is mounted on the mounting frame 201. The second lead screw 217 is rotatably mounted on the second U-shaped bracket 216 and then connected to the second motor 215. The mounting base 219 is provided with a mounting plate 220 for mounting the optical detection component 209. The mounting base 219 is provided with a slot and a second clearance slot 212. The slot and the second clearance slot 212 are connected. The second nut 218 is engaged in the slot and then cooperates with the lead screw. The lead screw passes through the second clearance slot 212.

[0087] The mounting base 219 has a groove 221 below it. The second slider 208 is installed in the groove 221 and slides in cooperation with the second slide rail installed on the mounting bracket 201.

[0088] The present invention uses a second driving mechanism 207 to adjust the position of the optical detection component 209, which facilitates the testing of multi-unit test cards.

[0089] In this embodiment, the specific structure of the optical detection component 209 is as follows:

[0090] It includes a housing 301, a laser channel 302 and a refraction channel 303 are provided inside the housing 301, the laser channel 302 and the refraction channel 303 are connected, a light source assembly 304 is provided inside the laser channel 302, and a dichroic beam-splitting filter 305 is provided inside the refraction channel 303.

[0091] The plano-convex cylindrical mirror 306 is located within the refraction channel 303 and is positioned below the dichroic beam splitter filter 305. A light-transmitting hole 307 communicating with the refraction channel 303 is provided on the housing 301. A rear sensor 308 is installed on the housing 301. The sensor 308 is located within the refraction channel 303 and above the dichroic beam splitter filter 305. The plane of the plano-convex cylindrical mirror 306 faces the light-transmitting hole 307.

[0092] In this invention, light emitted from a light source assembly 304 illuminates a dichroic beam-splitting filter 305. The filter refracts the light, which then illuminates a plano-convex cylindrical mirror 306. Since the plane of the plano-convex cylindrical mirror 306 faces the light-transmitting aperture 307, the light, after being shaped by the mirror, forms a rectangular spot that illuminates the test card. The fluorescence reflected from the fluorescent marker on the test card passes through the plane of the mirror 306, converges on its convex surface, passes through the dichroic beam-splitting filter 305, and illuminates the sensor 308. The sensor 308 converts the fluorescence signal into an electrical signal, thus achieving the detection purpose. Although this invention reduces the amount of light illuminating the test card, by aligning the plane of the plano-convex cylindrical mirror 306 with the light-transmitting aperture 307, it not only increases the area of ​​the spot formed on the test card but also converges the reflected fluorescence, making the reflected fluorescence stronger. This facilitates the sensor 308 in receiving the fluorescence and improves the detection accuracy.

[0093] Further optimization involves placing a positive meniscus lens 321 within the refraction channel 303 between the dichroic beam splitter filter 305 and the sensor 308. The positive meniscus lens 321 further focuses the fluorescence passing through the dichroic beam splitter filter 305, thereby increasing the fluorescence intensity and improving the detection accuracy.

[0094] Further optimization includes a left outer shell 309 and a right outer shell 310. Both the left and right outer shells 310 include an integral horizontal portion 311 and a vertical portion 312. The horizontal portion 311 and the vertical portion 312 are connected to form an L-shaped structure. A horizontal groove 313 is provided on the horizontal portion 311, and a vertical groove 314 is provided on the vertical portion 312. After the left and right shells are connected together, the horizontal groove 313 forms the laser channel 302, and the vertical groove 314 forms the refraction channel 303. A notch 110 is provided at the lower end of the vertical portion 312, which forms a light-transmitting hole 307. A dichroic beam-splitting filter 305, a plano-convex cylindrical mirror 306, and a positive meniscus lens 321 are all fitted into the vertical groove 314 of the vertical portion 312, and the light source assembly 304 is installed in the horizontal groove 313.

[0095] The vertical groove 314 is provided with a first protrusion 315 and a second protrusion 316. Both the first and second protrusions are semi-circular arc structures, and a positive meniscus lens 321 mounting groove 130 is formed between the first and second protrusions.

[0096] Further optimization involves providing an arc-shaped surface 317 on the second protrusion 316, which matches the spherical surface of the positive meniscus lens 321.

[0097] The vertical part 312 is provided with a first slot 318 and a second slot 319. Both the first slot 318 and the second slot 319 are connected to the vertical groove 314, and the angle formed by the line connecting the first and second slots and the horizontal plane is 135°. The dichroic beam-splitting filter 305 is installed in the first and second slots.

[0098] Further optimization involves providing a semi-cylindrical groove 320 on the vertical part 312, which is connected to the vertical groove 314, and the plano-convex cylindrical mirror 306 is installed inside the semi-cylindrical groove 320.

[0099] The left and right outer shells 310 are connected by screws.

[0100] In practical use, the plano-convex cylindrical mirror 306, the color-shifting filter, and the positive meniscus lens 321 are simply installed inside the left and right housings 310 and then connected with screws. The left and right housings 310 are an integral structure made by injection molding. This makes the installation of the plano-convex cylindrical mirror 306, the color-shifting filter, and the positive meniscus lens 321 more convenient and easier to assemble.

[0101] The left outer shell 309 has a positioning protrusion, and the right outer shell 310 has a positioning groove. After the left and right outer shells 310 are connected, the positioning protrusion and the positioning groove engage, making assembly more convenient.

[0102] Among them, the light source component 304 is a laser component. Compared with high-power LED lamp beads, the light source of the laser component has a stronger light intensity, smaller size and longer lifespan.

[0103] Example 2

[0104] This embodiment discloses a dual-channel immunoassay analyzer, including a frame, a fluorescence chromatography immunoassay component 1 and a blood gas analysis component 2 mounted on the frame, a main control board connected to the fluorescence chromatography immunoassay component 1 and the blood gas analysis component 2 is disposed inside the frame, a housing 3 is disposed on the frame, the housing 3 is mounted with a touch screen connected to the main control board, and the housing is provided with test card inlet / outlet 4 corresponding to the fluorescence chromatography immunoassay component and the blood gas analysis component, the fluorescence chromatography immunoassay component 1 is the fluorescence chromatography immunoassay component described in Embodiment 1; this invention does not involve specific improvements to the testing method, but only improvements to the mechanism.

[0105] It should be noted that the blood gas analysis component 2 is a blood gas analysis instrument of the invention applied for by our company on November 30, 2021, with application number CN202111445135.5. In this embodiment, its specific structure and detection method will not be described in detail.

[0106] Although preferred embodiments of the invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including both the preferred embodiments and all changes and modifications falling within the scope of the invention.

[0107] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. It should be noted that any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A fluorescence chromatography-immunoassay assembly, comprising a mounting frame and a detection and analysis mainboard mounted on the mounting frame for detecting and analyzing samples, characterized in that: It also includes a card holder, an optical detection assembly, a first drive mechanism and a second drive mechanism, with the card holder and the optical detection assembly slidably mounted on the mounting bracket; The first drive mechanism is connected to the card holder and is used to drive the card holder to move on the mounting frame. The card holder is used to install test cards. The optical detection component is connected to the second drive mechanism and is slidably mounted on the mounting frame through the second drive mechanism. The second drive mechanism is used to drive the optical detection component to move. The optical detection component moves in the opposite direction to the card tray, and the detection and analysis motherboard is connected to the optical detection component. The card holder is provided with a guide groove, and a first guide rail and a second guide rail are provided in the guide groove, forming a first sliding area between the first guide rail and the second guide rail; Test cards include single-piece test cards, triple-piece test cards, and five-piece test cards. The triple-piece test cards and five-piece test cards are provided with a first guide groove and a second guide groove that correspond to the first guide rail and the second guide rail, respectively. The two side walls of the guide groove form a limiting part to limit the five-piece test card; the distance between the first and second guide rails matches the distance of the single test card, and the distance between the two side walls of the guide groove matches the distance of the five-piece test card. The card holder is slidably mounted on the mounting bracket via a sliding assembly; The first drive mechanism includes a first motor, a first U-shaped bracket, a first lead screw, and a first nut. The first U-shaped bracket is mounted on the mounting bracket, the first lead screw is rotatably mounted on the first U-shaped bracket, the first motor is mounted on the first U-shaped bracket and connected to the first lead screw, and the first nut is engaged with the first lead screw and connected to the card holder. The card holder has a connecting part on its side, and the connecting part has a mounting groove and a relief groove communicating with the mounting groove. After the first nut is engaged in the relief groove, the first lead screw passes through the relief groove.

2. The fluorescence chromatography immunoassay assembly according to claim 1, characterized in that: The second guide rail has a notch, and an elastic part is provided inside the notch. The elastic part is used to contact the side wall of the single test card or the side wall of the second guide groove of the triple test card or the five-piece test card.

3. The fluorescence chromatography immunoassay assembly according to claim 1, characterized in that: The second drive mechanism includes a second motor, a second U-shaped bracket, a second lead screw, a second nut, and a mounting base. The mounting base is slidably mounted on the mounting frame via a second slider and a second slide rail. The second U-shaped bracket is mounted on the mounting frame. The second lead screw is rotatably mounted on the second U-shaped bracket and then connected to the second motor. The mounting base is provided with a mounting plate for mounting the optical detection component. The mounting base is provided with a slot and a second clearance slot. The slot and the second clearance slot are connected. The second nut is engaged in the slot and then cooperates with the lead screw. The lead screw passes through the second clearance slot.

4. The fluorescence chromatography immunoassay assembly according to claim 1, characterized in that: The optical detection assembly includes a housing, within which a laser channel and a refraction channel are arranged, connected to each other. A light source assembly is located within the laser channel, and a dichroic beam-splitting filter is located within the refraction channel. A plano-convex cylindrical mirror is also located within the refraction channel, positioned below the dichroic beam-splitting filter. A light-transmitting aperture communicating with the refraction channel is provided on the housing. A rear sensor is mounted on the housing, located within the refraction channel and above the dichroic beam-splitting filter. The plane of the plano-convex cylindrical mirror faces the light-transmitting aperture. The housing is connected to a second drive mechanism, and the sensor is connected to a detection and analysis mainboard.

5. A fluorescence chromatography immunoassay assembly according to claim 4, characterized in that: A positive meniscus lens is placed between the dichroic beam splitter and the sensor within the refraction channel.

6. The fluorescence chromatography immunoassay assembly according to claim 5, characterized in that: The outer casing includes a left outer casing and a right outer casing. Both the left and right outer casings include an integral horizontal part and a vertical part. The horizontal part and the vertical part are connected to form an L-shaped structure. A horizontal groove is provided on the horizontal part and a vertical groove is provided on the vertical part. After the left and right outer casings are connected together, the horizontal groove forms the laser channel and the vertical groove forms the refraction channel. A notch is provided at the lower end of the vertical part, and the notch forms a light-transmitting hole. The dichroic beam-splitting filter, the plano-convex cylindrical mirror and the positive meniscus lens are all installed in the vertical groove of the vertical part, and the light source assembly is installed in the horizontal groove.

7. A fluorescence chromatography immunoassay assembly according to claim 6, characterized in that: The vertical groove has a first protrusion and a second protrusion, both of which are semi-circular arc structures, forming a positive meniscus lens mounting groove between them; the vertical part has a first slot and a second slot, both of which are connected to the vertical groove, and the angle between the line connecting the first and second slots and the horizontal plane is 135°, and the dichroic beam-splitting filter is installed in the first and second slots; the vertical part has a semi-cylindrical groove, which is connected to the vertical groove, and the plano-convex cylindrical mirror is installed in the semi-cylindrical groove.

8. A dual-channel immunoassay analyzer, comprising a frame, a fluorescence chromatography immunoassay component and a blood gas analysis component mounted on the frame, a main control board connected to the fluorescence chromatography immunoassay component and the blood gas analysis component being disposed within the frame, a housing being disposed on the frame, the housing being equipped with a touch screen connected to the main control board, and the housing being provided with test card inlet / outlet ports corresponding to the fluorescence chromatography immunoassay component and the blood gas analysis component, characterized in that: The fluorescence chromatography-immunoassay kit is the fluorescence chromatography-immunoassay kit described in any one of claims 1-7.

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