Preparation process of anshen niuhuang pill medicine powder

Abstract

The application belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a preparation process of Angong Niuhuang Pill medicine powder, which comprises the following steps: 1) crushing four kinds of medicinal materials of Coptis chinensis, Gardenia, Scutellaria baicalensis and Curcuma zedoary according to a prescription amount, and preliminarily crushing the four kinds of medicinal materials into 40-60 mesh mixed powder A for standby; 2) putting prescription amounts of ox gall, concentrated water buffalo horn powder, artificial musk and borneol into a low-temperature vibration grinder, and grinding under the condition of-20 to-15 DEG C; putting prescription amounts of cinnabar superfine powder, pearl superfine powder and realgar superfine powder into the low-temperature vibration grinder, and continuing to grind under the condition of-20 to-15 DEG C to obtain mixed powder B; and 3) putting the mixed powder B into the mixed powder A, and continuing to grind and crush. The application adopts low-temperature grinding, avoids volatilization loss of borneol, musk, ox gall and other medicines containing heat-sensitive components, simultaneously completes mixing of the medicine powder in powder modification inclusion grinding, saves the traditional sieving and mixing processes, simplifies production operation, and reduces pollution and loss.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a preparation process of Angong Niuhuang Pills medicinal powder. Background Art

[0002] Angong Niuhuang Wan is one of the most renowned emergency remedies in traditional Chinese medicine. It originated in the Shangjiao chapter of "Bingbing Tiaobian" (Treatise on Plagues) by Wu Jutong, a Qing Dynasty epidemiologist. It is considered one of the "three treasures" of TCM for treating high fever. The formula consists of 11 herbs: bezoar, turmeric, rhinoceros horn, musk, pearl, gardenia, coptis root, scutellaria baicalensis, cinnabar, realgar, and borneol. Angong Niuhuang Wan has the properties of clearing heat and detoxifying, calming the nerves and invigorating the mind. It is primarily used to treat symptoms such as high fever and coma caused by plague, stroke, facial paralysis, muscle and vein traction, and phlegm-induced epilepsy. Its clinical efficacy is unique and proven. Angong Niuhuang Wan has been included in the Chinese Pharmacopoeia and is listed in the national drug standard. Within the entire formula, the bezoar, musk, and borneol are the most important, significantly impacting the overall effect.

[0003] The national standard prescription for Angong Niuhuang Wan is "bezoar 100g, musk (or artificial musk) 25g, buffalo horn concentrated powder 200g, pearl 50g, cinnabar 100g, realgar 100g, borneol 25g, coptis 100g, scutellaria 100g, gardenia 100g, and curcuma 100g".

[0004] The national drug standard for Angong Niuhuang Wan states that the preparation method for the powdered version of Angong Niuhuang Wan is as follows: "The above eleven ingredients are ground or pulverized into very fine powders with pearls; cinnabar and realgar are separately ground into very fine powders with water; coptis root, scutellaria baicalensis, gardenia jasminoides, and curcuma are pulverized into fine powders; bezoar, concentrated powder of buffalo horn, artificial musk, and borneol are finely ground, mixed with the above powders, sieved, and mixed to obtain the powdered version." During the production process, it was discovered that when the method prescribed by the national standard (i.e., pulverization---mixing---screening---mixing process) was followed, the fineness (particle size) of the fine powders of the various medicinal materials obtained varied greatly, and the proportions of the prescribed medicinal materials used in the prescriptions varied widely. This made it very easy for the powders of the various medicinal materials to not be completely mixed evenly, resulting in uneven medicinal composition between each pill, causing uneven drug quality and directly affecting the efficacy of the drug.

[0005] Therefore, it is necessary to improve the preparation process of the existing Angong Niuhuang Wan drug powder to ensure the quality of the Angong Niuhuang Wan drug. Summary of the Invention

[0006] The purpose of the present invention is to overcome the above-mentioned problems existing in the traditional technology and provide a preparation process of Angong Niuhuang Wan medicinal powder.

[0007] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0008] A preparation process of Angong Niuhuang Wan medicinal powder comprises the following steps:

[0009] 1) The prescribed amount of Coptidis rhizome, Gardenia jasminoides, Scutellaria baicalensis, and Curcuma aromatica were conventionally ground into a 40-60 mesh mixed powder A for later use;

[0010] 2) Add the prescribed amount of bezoar, buffalo horn concentrated powder, artificial musk, and borneol into a low-temperature vibration grinder and grind at -20 to -15°C for 25 to 35 minutes; add the prescribed amount of ultrafine cinnabar powder, ultrafine pearl powder, and ultrafine realgar powder, and continue grinding at -20 to -15°C for 17 to 23 minutes to obtain mixed powder B;

[0011] 3) Add mixed powder A into mixed powder B, continue grinding for 5 to 10 minutes, and take out to obtain Angong Niuhuang Wan medicinal powder.

[0012] Furthermore, in the preparation process of Angong Niuhuang Wan medicinal powder as described above, the fineness of the mixed powder A obtained in step 1) satisfies the following requirements: all of the mixed powder A can pass through a 120-mesh standard sieve, and more than 95% of the mixed powder A can pass through a 150-mesh standard sieve.

[0013] Furthermore, in the preparation process of Angong Niuhuang Wan medicinal powder as described above, the fineness of the mixed powder B obtained in step 2) satisfies the following requirements: all of the mixed powder B can pass through a 200-mesh standard sieve, and more than 90% of the mixed powder B can pass through a 300-mesh standard sieve.

[0014] Furthermore, in the preparation process of the Angong Niuhuang Wan medicinal powder as described above, in step 2), bezoar, buffalo horn concentrated powder, artificial musk, and borneol are put into a low-temperature vibration grinder and ground at -20 to -15°C for 30 minutes.

[0015] Furthermore, in the preparation process of the Angong Niuhuang Wan medicinal powder as described above, in step 2), ultrafine cinnabar powder, ultrafine pearl powder, and ultrafine realgar powder are added, and grinding is continued at -20 to -15°C for 20 minutes.

[0016] Furthermore, in the preparation process of the Angong Niuhuang Wan medicinal powder as described above, in step 2), the fineness of the cinnabar ultrafine powder, the pearl ultrafine powder, and the realgar ultrafine powder respectively meets the requirement that all of them can pass through a 150-mesh standard sieve, and more than 95% can pass through a 200-mesh standard sieve.

[0017] Furthermore, according to the preparation process of the Angong Niuhuang Wan medicinal powder as described above, the Angong Niuhuang Wan medicinal powder obtained in step 3) is a composite particle with a core-shell structure, wherein the particles of the mixed powder A are core particles and the mixed powder B is wrapped around the outside of the core particles; the Angong Niuhuang Wan medicinal powder is in the form of agglomerates under an optical microscope, and the powder composed of the agglomerates can all pass through an 80-mesh standard sieve.

[0018] Angong Niuhuang Pills medicinal powder is prepared by the above-mentioned preparation process.

[0019] The beneficial effects of the present invention are:

[0020] 1. The present invention draws on particle design and powder modification technology to solve the problem of powder particles with large size differences and difficulty in mixing evenly.

[0021] 2. The present invention adopts low-temperature grinding to avoid the volatilization loss of drugs containing heat-sensitive ingredients such as borneol, musk, and bezoar.

[0022] 3. The present invention simultaneously completes the mixing of medicinal powders during powder modification and inclusion grinding, eliminating the traditional screening and mixing processes, simplifying production operations, and reducing pollution and loss.

[0023] Of course, any product implementing the present invention does not necessarily need to achieve all of the above advantages at the same time. DETAILED DESCRIPTION

[0024] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0025] The relevant specific embodiments of the present invention are as follows:

[0026] Example 1

[0027] A preparation process of Angong Niuhuang Wan medicinal powder comprises the following steps:

[0028] 1) The prescribed amount of Coptidis rhizome, Gardenia jasminoides, Scutellaria baicalensis, and Curcuma aromatica were conventionally ground into a 40-mesh mixed powder A for later use;

[0029] 2) Add the prescribed amount of bezoar, buffalo horn concentrated powder, artificial musk, and borneol into a low-temperature vibration grinder and grind at -20°C for 30 minutes; add the prescribed amount of ultrafine cinnabar powder, ultrafine pearl powder, and ultrafine realgar powder, and continue grinding at -20°C for 20 minutes to obtain mixed powder B;

[0030] 3) Add mixed powder A into mixed powder B, continue grinding for 5 minutes, and take out to obtain Angong Niuhuang Wan medicinal powder.

[0031] The prepared Angong Niuhuang Wan drug powder was placed in a clean white enamel dish and spread flat. Visual inspection showed that the powder color was uniform and there were no red / dark particles visible to the naked eye under a magnifying glass.

[0032] Example 2

[0033] A preparation process of An Gong Niuhuang pill medicine powder, comprising the following steps:

[0034] 1) The prescription amount of Coptis, Gardenia, Scutellaria and Radix Curcumae are conventionally crushed, and are preliminarily crushed into 50-mesh mixed powder A for standby;

[0035] 2) The prescription amount of ox gall, concentrated water buffalo horn powder, artificial musk and borneol are put into a low-temperature vibration grinder, and are ground for 30 min under the condition of-17℃; the prescription amount of cinnabar, pearl and realgar are put into the low-temperature vibration grinder, and are continuously ground for 20 min under the condition of-17℃, to obtain mixed powder B;

[0036] 3) The mixed powder A is put into the mixed powder B, and is continuously ground for 8 min, and is taken out, to obtain the An Gong Niuhuang pill medicine powder.

[0037] The prepared An Gong Niuhuang pill medicine powder is placed in a clean white enamel tray and is spread flat, and is visually inspected, and the powder color is uniform and consistent, and there is no red / dark particles visible under a magnifying glass.

[0038] According to the equidistant sampling method, nine portions of the powder spread on the white enamel tray are sampled, and are respectively placed under a microscope to observe the powder particles and particle size, and it can be seen that under the lens, the powder particles are all in the form of agglomerates, and the agglomerate size is basically uniform.

[0039] The 9 samples are respectively detected for muscone and baicalin contents by high-efficiency gas chromatography and high-efficiency liquid chromatography, and the results are shown in Table 1:

[0040] Table 1

[0041] Sample No. Musk ketone content (mg / g) Baicalin content (%) 1 0.60 9.4 2 0.62 9.4 3 0.62 9.5 4 0.62 9.3 5 0.60 9.4 6 0.62 9.4 7 0.62 9.5 8 0.60 9.3 9 0.60 9.3 average 0.61 9.4 RSD 1.72％ 0.83％

[0042] It can be known that the muscone and baicalin contents are basically consistent, which indicates that the An Gong Niuhuang pill powder prepared by the process of the embodiment has mixed uniform effective components, and ensures the uniformity of the prepared pill quality.

[0043] Example 3

[0044] A preparation process of An Gong Niuhuang pill medicine powder, comprising the following steps:

[0045] 1) The prescription amount of Coptis, Gardenia, Scutellaria and Radix Curcumae are conventionally crushed, and are preliminarily crushed into 60-mesh mixed powder A for standby;

[0046] 2) Add the prescribed amount of bezoar, buffalo horn concentrated powder, artificial musk, and borneol into a low-temperature vibration grinder and grind at -15°C for 30 minutes; add the prescribed amount of ultrafine cinnabar powder, ultrafine pearl powder, and ultrafine realgar powder, and continue grinding at -15°C for 20 minutes to obtain mixed powder B;

[0047] 3) Add mixed powder A into mixed powder B, continue grinding for 10 minutes, and take out to obtain Angong Niuhuang Wan medicinal powder.

[0048] The prepared Angong Niuhuang Wan drug powder was placed in a clean white enamel dish and spread flat. Visual inspection showed that the powder color was uniform and there were no red / dark particles visible to the naked eye under a magnifying glass.

[0049] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to specific embodiments. Obviously, many modifications and variations are possible based on the contents of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A preparation process for Angong Niuhuang Wan medicinal powder, characterized in that: The steps include: 1) Grind the prescribed amount of Coptis chinensis, Gardenia jasminoides, Scutellaria baicalensis, and Curcuma aromatica into a 40-60 mesh mixed powder A for later use; 2) Place the prescribed amount of bezoar, buffalo horn concentrated powder, artificial musk, and borneol in a low-temperature vibration grinder and grind at -20 to -15°C for 30 minutes. Add the prescribed amount of ultrafine cinnabar powder, ultrafine pearl powder, and ultrafine realgar powder and continue grinding at -20 to -15°C for 20 minutes to obtain mixed powder B. 3) Add mixed powder A to mixed powder B, continue grinding and pulverizing for 5 to 10 minutes, and take out to obtain Angong Niuhuang Wan medicinal powder; Angong Niuhuang Wan medicinal powder is a composite particle with a core-shell structure, wherein the particles of mixed powder A are core particles and mixed powder B is wrapped around the outside of the core particles; Angong Niuhuang Wan medicinal powder is granular under an optical microscope, and the granular powder composed of the granular particles can all pass through an 80-mesh standard sieve.

2. The preparation process of Angong Niuhuang Wan medicinal powder according to claim 1, wherein The mixed powder A obtained in step 1) has a fineness that satisfies the following requirements: all of the mixed powder can pass through a 120-mesh standard sieve, and more than 95% of the mixed powder can pass through a 150-mesh standard sieve.

3. The preparation process of Angong Niuhuang Wan medicinal powder according to claim 1, wherein: The fineness of the mixed powder B obtained in step 2) is such that all of the mixed powder can pass through a 200-mesh standard sieve, and more than 90% of the mixed powder can pass through a 300-mesh standard sieve.

4. The preparation process of Angong Niuhuang Wan medicinal powder according to claim 1, wherein: In step 2), the fineness of each of the cinnabar ultrafine powder, the pearl ultrafine powder, and the realgar ultrafine powder is such that all of the powder can pass through a 150-mesh standard sieve, and more than 95% of the powder can pass through a 200-mesh standard sieve.

5. An Angong Niuhuang Wan medicinal powder, prepared by the preparation process according to any one of claims 1 to 4.