Multifunctional artificial organ device

Abstract

The application discloses a multifunctional artificial organ device, which comprises a shell, a blood pipe bundle and a hydrogel, the blood pipe bundle is contained in a containing cavity, the blood pipe bundle is communicated with a blood inlet and a blood outlet, the hydrogel is filled in the containing cavity, the hydrogel comprises a gel layer and allogeneic therapeutic cells, the allogeneic therapeutic cells are wrapped in the inside of the gel layer, and the allogeneic therapeutic cells absorb nutrient substances and oxygen separated from the blood pipe bundle and secrete therapeutic factors to the blood pipe bundle. The multifunctional artificial organ device in the embodiment of the application wraps the allogeneic therapeutic cells in the inside of the gel layer, so that the immune rejection of the human body is reduced, the human blood is filtered through the blood pipe bundle, the nutrient substances and oxygen are separated from the blood pipe bundle for normal metabolism of the allogeneic therapeutic cells, the allogeneic therapeutic cells generate therapeutic factors, the therapeutic factors flow to internal organs along with the blood, and the purpose of disease treatment is achieved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a multifunctional artificial organ device. Background Technology

[0002] When a patient's organ is damaged or has lost function, organ transplantation is the clinical practice, replacing the patient's organ with a functional allogeneic organ. However, in reality, many patients cannot receive timely treatment due to a lack of donor organs. Organ transplantation surgery, whether orthotopic or heterotopic, is highly complex; furthermore, allogeneic organs often face the influence of the patient's immune system, leading to rejection and failure. When the implanted allogeneic organ malfunctions, a second transplantation is necessary, causing secondary harm to the patient and potentially resulting in permanent immune rejection. Therefore, there is an urgent clinical need to find a device with lower rejection rates that can be used to treat patients with organ damage or loss of function. Summary of the Invention

[0003] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention proposes a multifunctional artificial organ device capable of treating diseases caused by organ damage or loss of cell function, and reducing the intensity of rejection by human immune components.

[0004] A multifunctional artificial organ device according to an embodiment of the present invention includes:

[0005] The housing has an internal cavity, and the housing has a blood inlet and a blood outlet, both of which are connected to the cavity.

[0006] Multiple blood tubing bundles are provided, each blood tubing bundle is housed within the receiving cavity, one end of each blood tubing bundle is connected to the blood inlet, and the other end of each blood tubing bundle is connected to the blood outlet;

[0007] A hydrogel, filling the cavity, comprises a gel layer and allogeneic therapeutic cells, the allogeneic therapeutic cells being encapsulated within the gel layer, the allogeneic therapeutic cells absorbing substances precipitated from the blood vessels and secreting therapeutic factors into the cavity.

[0008] A multifunctional artificial organ device according to an embodiment of the present invention has at least the following beneficial effects:

[0009] In this embodiment of the invention, a multifunctional artificial organ device is provided, in which allogeneic therapeutic cells are encapsulated inside a gel layer. Immune components in the blood do not come into direct contact with the allogeneic therapeutic cells, which can reduce the body's immune rejection. The human blood is filtered through blood vessels, and nutrients and oxygen are released from the blood vessels to supply the allogeneic therapeutic cells with normal metabolism. This also enables the allogeneic therapeutic cells to produce therapeutic factors. After the therapeutic factors flow with the blood into the patient's body, they achieve the purpose of treating the disease.

[0010] According to some embodiments of the present invention, two mounting plates are further included, which are placed inside the housing and connected to the inner wall of the housing, and the two ends of the blood tubing are respectively fixed to the two mounting plates.

[0011] According to some embodiments of the present invention, the mounting plate includes two oppositely arranged mounting portions with a gap between them. Each mounting portion has a plurality of spaced mounting openings. The mounting openings of the two mounting portions correspond one-to-one and are arranged facing each other. Two mounting openings are inserted into each side of each blood tube bundle. Adjacent blood tube bundles and the mounting portions enclose a reaction chamber, and the hydrogel fills the reaction chamber.

[0012] According to some embodiments of the present invention, the mounting plate has mounting holes, the end of the blood tubing is inserted into the mounting holes, the two mounting plates divide the receiving cavity into a first buffer cavity, a blood flow cavity and a second buffer cavity, the blood flow cavity is located between the two mounting plates, the blood inlet is in communication with the first buffer cavity, and the blood outlet is in communication with the second buffer cavity.

[0013] According to some embodiments of the present invention, the blood tubing includes multiple blood flow tubes arranged side by side to form the blood tubing, and the two ends of the blood tubing are provided with sealing portions, the sealing portions are inserted into the mounting holes, and the blood flow tubes are fixedly connected at the sealing portions.

[0014] According to some embodiments of the present invention, the housing includes at least one partition located between two mounting plates, the edge of the partition being connected to the inner wall of the housing, the partition dividing the blood flow chamber into a plurality of perfusion units, the partition having a through hole through which the blood tubing passes.

[0015] According to some embodiments of the present invention, the housing includes an infusion port that communicates with the blood flow cavity, and a valve for opening and closing the infusion port is provided at the infusion port.

[0016] According to some embodiments of the present invention, the housing includes a first outer shell and a second outer shell, the first outer shell and the second outer shell being movably connected to close or open the receiving cavity.

[0017] According to some embodiments of the present invention, the housing further includes a plurality of filter screens, the filter screens being housed within the second buffer cavity, and the edges of the filter screens being connected to the inner wall of the housing.

[0018] According to some embodiments of the present invention, the housing further includes two flushing ports, which are respectively connected to the first buffer chamber and the second buffer chamber.

[0019] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0020] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:

[0021] Figure 1 This is a schematic diagram of the structure of one embodiment of a multifunctional artificial organ device according to the present invention;

[0022] Figure 2 This is a schematic diagram illustrating the fit between a blood vessel bundle and a housing in one embodiment.

[0023] Figure 3 This is a schematic diagram illustrating the fit between a blood vessel bundle and a mounting plate according to one embodiment.

[0024] Figure 4 This is a cross-sectional view of an embodiment of the hydrogel of the present invention;

[0025] Figure 5 for Figure 1 A cross-sectional view of one embodiment of the housing;

[0026] Figure 6 This is a schematic diagram of one embodiment of the mounting plate of the present invention;

[0027] Figure 7 This is a schematic diagram of the structure of a blood vascular bundle according to an embodiment of the present invention;

[0028] Figure 8 for Figure 7 Cross-sectional view of the blood vascular bundle;

[0029] Figure 9 for Figure 1 A side view of a multifunctional artificial organ device.

[0030] Figure label:

[0031] The system comprises: a housing 100, a receiving cavity 110, a blood inlet 120, a blood outlet 130, a mounting plate 140, a mounting hole 141, a mounting part 142, a mounting opening 1421, a reaction chamber 150, a first buffer chamber 160, a blood flow chamber 170, an infusion unit 171, a second buffer chamber 180, a partition 190, an infusion port 101, a first outer shell 102, a second outer shell 103, an rinsing port 104, and a housing 105; a blood tubing bundle 200, a blood flow tube 210, and a sealing part 220; a hydrogel 300, a gel layer 310, and allogeneic therapeutic cells 320. Detailed Implementation

[0032] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0033] In the description of this invention, it should be understood that the orientation descriptions, such as up, down, front, back, left, right, etc., are based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting this invention.

[0034] In the description of this invention, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. The use of "first" and "second" in the description is merely for distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the order of the indicated technical features.

[0035] In the description of this invention, unless otherwise explicitly defined, terms such as "set up," "install," and "connect" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this invention in conjunction with the specific content of the technical solution.

[0036] In the description of this invention, the terms "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0037] Reference Figures 1 to 3 This invention provides a multifunctional artificial organ device, comprising a housing 100, blood tubing 200, and hydrogel 300. The housing 100 has an internal cavity 110, and a side portion has a blood inlet 120 and a blood outlet 130. Both the blood inlet 120 and the blood outlet 130 communicate with the cavity 110. Both the blood inlet 120 and the blood outlet 130 can be connected to artificial blood vessels via quick connectors, and then connected to human blood vessels. Multiple blood tubing bundles 200 are provided. The device is housed within a receiving cavity 110. One end of a blood tubing 200 is connected to a blood inlet 120, and the other end is connected to a blood outlet 130. Human blood enters the blood tubing 200 through the blood inlet 120, flows through the blood tubing 200, and exits the receiving cavity 110 through the blood outlet 130. The blood that has exited the receiving cavity 110 re-enters the human body, thus achieving blood circulation between the human body and a multifunctional artificial organ device. Hydrogel 300 fills the receiving cavity 110, such as... Figure 4 As shown, the hydrogel 300 includes a gel layer 310 and allogeneic therapeutic cells 320. The allogeneic therapeutic cells 320 are encapsulated inside the gel layer 310. The allogeneic therapeutic cells 320 secrete corresponding therapeutic factors when stimulated by substances exuded from human blood. The therapeutic factors can be hormones or other secretions. Due to the hydrophilicity and high porosity of the hydrogel 300, it can meet the needs of nutrient exchange and waste removal between the allogeneic therapeutic cells 320 and the blood.

[0038] When human blood flows through the blood duct bundle 200, nutrients, oxygen, and other substances are released into the blood duct bundle 200. These substances are used to maintain the metabolism and activity of the allogeneic therapeutic cells 320. The gel layer 310 of the hydrogel 300 has a high porosity and a small pore size, which can effectively block the entry of immune components in human blood. The immune components in the blood will not come into direct contact with the allogeneic therapeutic cells, reducing the rejection between human blood and allogeneic therapeutic cells 320. Furthermore, this substance can stimulate the allogeneic therapeutic cells 320 to secrete therapeutic factors. The therapeutic factors have the effect of treating internal organs. The therapeutic factors enter the blood duct bundle 200, mix with the blood, and are discharged from the shell 100 along with the blood. When the therapeutic factors flow with the blood to the corresponding internal organs, the purpose of treating the disease is achieved.

[0039] Therefore, in this embodiment of the invention, the multifunctional artificial organ device encapsulates the allogeneic therapeutic cells 320 inside the gel layer 310 to reduce the body's immune rejection. The human blood is filtered through the blood tubules 200, allowing the blood tubules 200 to release nutrients and oxygen for the allogeneic therapeutic cells 320 to metabolize normally. The allogeneic therapeutic cells 320 also produce therapeutic factors for treating organs. These therapeutic factors flow with the blood to the internal organs, thereby achieving the purpose of treating the disease.

[0040] It should be noted that the multifunctional artificial organ device of the present invention can be applied to diseases caused by organ damage or cell dysfunction. When the patient's original organ function is not completely or completely lost, the therapeutic factors secreted by the allogeneic therapeutic cells 320 of the transplanted multifunctional artificial organ device will flow with the human bloodstream. These therapeutic factors can treat the disease, compensating for the functional loss of the original organ or cell, thus possessing the basic functions of the original human organ. The therapeutic factors secreted by the cells within the device compensate for the loss of organ function and maintain normal human metabolism.

[0041] In addition, due to its small size, the multifunctional artificial organ device can be transplanted into the human body, such as the iliac fossa or splenic fossa. The blood inlet 120 and blood outlet 130 of the multifunctional artificial organ device can be directly connected to the artificial blood vessel from the body through a connector, and then connected to the human blood vessel, without being contaminated by the external environment.

[0042] The aforementioned allogeneic therapeutic cells 320 can be one or more of hepatocytes, kidney cells, and pancreatic islet cells. Taking pancreatic islet cells as an example, the islet cells absorb oxygen and nutrients released from the blood vascular bundle 200 for metabolism and secrete insulin. Insulin enters the blood vascular bundle 200 and flows with the blood. Insulin promotes glucose metabolism in the blood to lower the patient's blood sugar, thereby achieving the effect of treating diabetes. It should be noted that if the allogeneic therapeutic cells 320 are pancreatic islet cells and hepatocytes, through a similar process, it is possible to treat patients with diabetes, liver disease, and kidney disease. Therefore, a multifunctional artificial organ device can be widely used in the biomedical field.

[0043] Specifically, when used for liver disease treatment, the size of hydrogel 300 is 50-600 μm, and the allogeneic therapeutic cells 320 are hepatocytes, with approximately 800-1500 cells / 100 μm distributed within the gel layer 310. When used for diabetes treatment, the allogeneic therapeutic cells are pancreatic islet cells, approximately 1 IEQ / 100-600 μm. When used for kidney disease treatment, it should be a shear-thinning or flowable hydrogel. Hydrogel 300 can be a macroscopic hydrogel or microgel. The material of hydrogel 300 can be one or more of the following: natural polysaccharides, such as cellulose and its derivatives, gelatin, collagen, alginate, hyaluronic acid, chitosan and its derivatives, chondroitin sulfate, etc. Hydrogel 300 can also be one or more of the following: synthetic polymers, such as polyethylene glycol, polyvinyl alcohol, poly(2-hydroxyethyl methacrylate), poly(N-isopropylacrylamide), guanidine polymers, etc.

[0044] The aforementioned quick connectors are Luer connectors, etc. The quick connectors connect to artificial blood vessels, which can be made of polytetrafluoroethylene (PTFE), polyurethane (PU), or 3D printed blood vessels, etc. The artificial blood vessels are matched with human blood vessels. If a multifunctional artificial organ device is transplanted into the human iliac fossa, the blood inlet 120 is connected to the iliac artery, and the blood outlet 130 is connected to the iliac vein. After the artificial blood vessel is connected to the human blood vessel, the quick connectors enable the circulation of blood between the multifunctional artificial organ device and the human body.

[0045] like Figure 5 As shown, the housing 100 also includes two mounting plates 140, which are housed in the receiving cavity 110. The edges of the mounting plates 140 are connected to the inner wall of the housing 100, thereby dividing the receiving cavity 110 of the housing 100 into a first buffer cavity 160, a blood flow cavity 170 and a second buffer cavity 180. The blood flow cavity 170 is located between the two mounting plates 140.

[0046] The blood vascular bundle 200 can be a blood fiber tube or a planar membrane. The fiber tube is made of a polymer such as polytetrafluoroethylene (PTFE), polyurethane (PU), or polyethylene terephthalate (PET), and is prepared by electrospinning, biaxial stretching, phase separation, or granulation pore-forming. To prevent blood clotting during blood flow, the surface of the fiber tube can be treated with anticoagulation, such as physical coating, chemical deposition, or chemical grafting.

[0047] Furthermore, when the blood tubing 200 is installed inside the housing 100, refer to... Figure 6The mounting plate 140 has mounting holes 141. The two ends of the blood tubing 200 are respectively inserted into the mounting holes 141 of the two mounting plates 140. The blood inlet 120 communicates with the first buffer chamber 160, and the blood outlet 130 communicates with the second buffer chamber 180. Blood entering the housing 100 from the outside first enters the first buffer chamber 160. The blood is blocked by the mounting plate 140 and buffered within the first buffer chamber 160 to reduce the impact of blood pressure on the blood tubing 200 and other components. Furthermore, both the first buffer chamber 160 and the second buffer chamber 180 are located at the ends of the housing 100, and the blood inlet 120 and blood outlet 130 are interchangeable, improving the ease of use of this multifunctional artificial organ device.

[0048] Reference Figure 7 and Figure 8 The blood vascular bundle 200 includes multiple blood flow tubes 210, which are arranged side by side to form the blood vascular bundle 200. Blood can flow within each blood flow tube 210. Due to the small diameter of the blood flow tubes 210, typically 0.1-75 μm, and the membrane thickness of 120-150 μm, the assembly of the blood flow tubes 210 into the mounting holes 141 is difficult. When the number of blood vascular bundles 200 is large, it greatly limits the assembly efficiency of a multifunctional artificial organ device. The cross-sectional size of the blood vascular bundle 200 is large, and the size of the mounting holes 141 can be adjusted accordingly, which facilitates the processing of the mounting holes 141 and the insertion of the blood vascular bundle 200 into the mounting holes 141.

[0049] It should be noted that each blood tube bundle 200 includes multiple blood flow tubes 210, and the diameter of each blood flow tube 210 may be the same or different, which can be controlled by adjusting the number of blood flow tubes 210; furthermore, the mounting plate 140 may be provided with multiple mounting holes 141, and in order to facilitate a more uniform distribution of hydrogel, the diameter of the mounting holes 141 may be the same or different.

[0050] The blood flow tube 210 can be a fiber tube or planar membrane with nanopores, made of a polymer such as polytetrafluoroethylene (PTFE), polyurethane (PU), polyethylene terephthalate (PET), or polyvinyl alcohol (PVA), prepared by commercial methods, electrospinning, biaxial stretching, granulation pore formation, or phase separation. Alternatively, it can be an inorganic nanofilm such as titanium dioxide (TiO2), gold oxide (Au2O3), or aluminum oxide (Al2O3), prepared by commercial methods, anodizing, laser processing, or micro-arc oxidation. To prevent blood clots, the surface of the blood tube bundle can be treated with anticoagulants, such as by physical coating, chemical deposition, or chemical grafting.

[0051] To further improve the ease of insertion of the blood vessel bundle 200 into the mounting hole 141, in this embodiment of the invention, sealing portions 220 are provided at both ends of the blood vessel bundle 200, and the blood flow tubes 210 are fixedly connected at the sealing portions 220. On the one hand, this prevents the blood flow tubes 210 within the blood vessel bundle 200 from dispersing; on the other hand, it facilitates insertion of the tube bundle 400 into the mounting hole 141. In one embodiment, the two ends of the blood vessel bundle 200 are sealed with a curing agent to form the sealing portions 220. Under the adhesive effect of the curing agent, multiple blood vessel bundles 200 are fixed together at the sealing portions 220. The curing agent can be made of silicone-based organic polymer polymethylsiloxane (PDMS), polyurethane (PU), or other curing agents.

[0052] When multiple mounting holes 141 are provided, the number of mounting holes 141 on the two mounting plates 140 is the same, so that both ends of each blood tube bundle 200 can be fixed. In one embodiment, the mounting holes 141 are equally distributed on the two mounting plates 140, and multiple blood tube bundles 200 are provided and arranged side by side. The side-by-side arrangement of blood tube bundles 200 separates the hydrogel 300 in a direction perpendicular to its extension, which can reduce the aggregation of hydrogel 300, make the distribution of hydrogel 300 in the blood flow cavity 170 more uniform, and make the material exchange between the allogeneic therapeutic cells 320 and the blood in the blood tube bundles 200 more sufficient.

[0053] In another embodiment, multiple mounting holes 141 and blood tubing bundles 200 are provided, and the blood tubing bundles 200 are distributed in an interlaced manner. The interlaced blood tubing bundles 200 separate the hydrogel 300 into different areas of the blood flow cavity 170 to reduce the aggregation of the hydrogel 300 and allow the allogeneic therapeutic cells 320 to fully exchange substances with the blood in the blood tubing bundles 200.

[0054] In one embodiment, the blood vessel bundle 200 can be selected as a polymer membrane such as PTFE, PU, ​​or PVA, or as a metal oxide membrane such as TiO2, Al2O3, or Au2O3. To prevent blood clots, the surface of the planar membrane can be treated with anticoagulation agents, such as physical coating, chemical deposition, or chemical grafting. When the blood vessel bundle 200 is installed in the housing 100 in the form of a planar membrane, such as... Figure 3 As shown, the mounting plate 140 includes two mounting portions 142 arranged opposite to each other, with a gap between the two mounting portions 142. Each mounting portion 142 has a plurality of spaced mounting openings 1421. The mounting openings 1421 of the two mounting portions 142 correspond one to one and are arranged facing each other. Two mounting openings 1421 are inserted into each side of each blood tube bundle 200. Adjacent blood tube bundles 200 and mounting portions 142 enclose a reaction chamber 150, and hydrogel 300 fills the reaction chamber 150.

[0055] It should be noted that, in the above embodiment, the mounting opening 1421 on the mounting part 142 forms a hole for mounting the blood tubing bundle 200, and the end of the blood tubing bundle 200 can pass through the mounting plate 140 and communicate with the first buffer chamber 160 and the second buffer chamber 180. In addition, the size of the planar membrane is relatively large compared to the blood fiber tube, which allows it to be connected to the mounting opening 1421 more conveniently. Furthermore, since the adjacent reaction chambers 150 are independent of each other, the hydrogel 300 is confined within each reaction chamber 150, which can prevent the hydrogel 300 from accumulating within the housing 100.

[0056] Furthermore, such as Figure 5 As shown, the housing 100 also includes at least one partition 190, which is located between two mounting plates. The edge of the partition 190 is connected to the inner wall of the housing 100. The partition 190 divides the blood flow chamber 170 into multiple perfusion units 171. The partition 190 has through holes through which blood vessels 200 pass. The partition 190 separates the hydrogel 300 along the extending direction of the blood vessels 200, so that the hydrogel 300 is evenly distributed in different perfusion units 171, thereby further improving the uniformity of the distribution of the hydrogel 300 in the blood flow chamber 170. Through the spaced distribution of different blood vessels 200 and the arrangement of the partition 190, the hydrogel 300 is separated in different directions, effectively improving the uniformity of the distribution of the hydrogel 300 in the blood flow chamber 170.

[0057] In one embodiment, the housing 100 further includes an infusion port 101, which communicates with the blood flow chamber 170. A valve for opening and closing the infusion port 101 is provided at the infusion port 101. Before use, hydrogel 300 is infused into the blood flow chamber 170 through the infusion port 101. The hydrogel 300 is evenly distributed between adjacent blood vessel bundles 200 and within each infusion unit 171. The valve is then closed, sealing the infusion port 101 and making the housing 100 airtight. After connecting the multifunctional artificial organ device to an artificial blood vessel via a quick connector, disease treatment can be performed. By providing the infusion port 101, the hydrogel 300 can be directly infused. Within the blood flow cavity 170, the hydrogel 300 can be evenly distributed within the blood flow cavity 170. Furthermore, multiple infusion ports 101 can be provided according to the number of infusion units 171. Each infusion unit 171 is connected to an infusion port 101. The hydrogel 300 enters each infusion unit 171 through the infusion port 101, which can prevent the hydrogel 300 after infusion from accumulating in a certain area of ​​the blood flow cavity 170 and ensure the uniformity of the distribution of the hydrogel 300 within each infusion unit 171.

[0058] In addition, such as Figure 9As shown, the housing 100 also includes a first outer shell 102 and a second outer shell 103, which are movably connected and can be opened and closed. For example, one side of the first outer shell 102 and the second outer shell 103 are hinged, and the other side of the first outer shell 102 and the second outer shell 103 are snapped together. When the first outer shell 102 and the second outer shell 103 are snapped together, they form a sealed housing 100, sealing the receiving cavity 110 inside the housing 100. When the first outer shell 102 and the second outer shell 103 are released from the snapping, the first outer shell 102 and the second outer shell 103 rotate relative to each other at the hinge and open, thus opening the housing 100. The first outer shell 102 and the second outer shell 103 are configured as an openable structure to facilitate the injection of hydrogel 300 into the housing 100. It should be noted that the first outer shell 102 and the second outer shell 103 are located between the two mounting plates 150, and the gap between them forms a blood flow cavity 170. During perfusion, by opening and closing the first outer shell 102 and the second outer shell 103, only the blood flow cavity 170 can be opened, and the hydrogel 300 can be perfused or replaced into the blood flow cavity 170, so that the first buffer cavity 160 and the second buffer cavity 180 remain sealed.

[0059] It should be noted that, since the blood tubing 200 and hydrogel 300 in this invention are independent of each other, and the blood tubing 200 is fixed by two mounting plates 140 and a partition 190, the blood tubing 200 is less affected when hydrogel infusion and hydrogel replacement, which facilitates the replacement of hydrogel 300 and the cleaning and reuse of a multifunctional artificial organ device. Furthermore, according to the needs of a multifunctional artificial organ device, the replacement of hydrogel 300 can be selected to target only one or more infusion units 171.

[0060] The first outer shell 102 and the second outer shell 103 can be configured as symmetrical or asymmetrical structures. In one embodiment, the first outer shell 102 and the second outer shell 103 are asymmetrical structures, with the mating position of the first outer shell 102 and the second outer shell 103 at 1 / 3-1 / 4 of the edge of the shell 100. The volume of the internal space of the second outer shell 103 is greater than the volume of the internal space of the first outer shell 102. The edges of the mounting plate 140 and the partition plate 190 are fixedly connected to the inner wall of the second outer shell 103. The second outer shell 103 has a higher capacity to accommodate hydrogel 300 than the first outer shell 102, and hydrogel 300 can be directly injected into the second outer shell 103. After the first outer shell 102 and the second outer shell 103 are closed, the edges of the mounting plate 140, the mounting plate 150 and the partition plate 190 abut against the inner wall of the first outer shell 102, making the first buffer cavity 160, the second buffer cavity 180 and the blood flow cavity 170 independent of each other.

[0061] In addition, the blood inlet 120 and the blood outlet 130 are disposed on the first housing 102 or the second housing 103. Compared with the first housing 102 and the second housing 103 being closed and the two being combined to form the blood inlet 120 or the blood outlet 130, it is easier to seal the blood inlet 120 or the blood outlet 130 by separately disposing of the blood inlet 120 or the blood outlet 130 on the first housing 102 or the second housing 103.

[0062] The first outer shell 102 or the second outer shell 103 is also provided with a flushing port 104. There are two flushing ports 104, which are respectively connected to the first buffer chamber 160 and the second buffer chamber 180. Pipes can be connected to the flushing ports 104. Blood entering the first buffer chamber 160 or the second buffer chamber 180 has the risk of coagulation. Physiological saline or other buffer solutions are flushed into the first buffer chamber 160 or the second buffer chamber 180 through the flushing ports 104 to flush out blood clots from the multifunctional artificial organ device, so as to avoid blood blocking the blood flow channel and affecting the blood flow efficiency.

[0063] The housing 100 is also provided with a filter screen 105, which is housed within the second buffer chamber 180. The edge of the filter screen 105 is connected to the inner wall of the housing 100. The filter screen 105 filters the blood flowing out of the housing 105, preventing blood clots from flowing into the body. The filter screen 105 has multiple layers, with different pore sizes in different layers to intercept blood clots of different sizes. Along the direction towards the blood outlet 130, the pore size of the filter screen 105 decreases sequentially. Through multi-stage filtration, smaller blood clots are deposited on the lowest filter screen 105, preventing blood clots from accumulating on the same filter screen 105.

[0064] The multifunctional artificial organ device also includes a pressure sensor, which can be set in the first buffer chamber 160, the second buffer chamber 180, or the blood flow chamber 170. The pressure sensor detects the pressure inside the housing 100 and transmits the detection data to the external system module via Bluetooth, infrared, or other means, so that the system module can obtain the internal pressure of the housing 100 at its current state and take corresponding measures to avoid the housing from cracking due to excessive pressure or the housing 100 from leaking, resulting in excessively low internal pressure. The pressure sensor can be made of ceramic, semiconductor, or organic materials.

[0065] In addition, the multifunctional artificial organ device also includes a blood parameter sensor, which is located inside the housing 100. This sensor detects the content of different elements in the blood and transmits the data to the external system module via Bluetooth, infrared, or other means. For example, when the allogeneic therapeutic cells 320 are pancreatic islet cells, the blood parameter sensor detects blood glucose levels to determine the therapeutic effect of the allogeneic therapeutic cells 320, achieving the goal of real-time monitoring of the working status of the multifunctional artificial organ device. The blood parameter sensor can be made of ceramic, semiconductor, or organic materials.

[0066] In addition, the multifunctional artificial organ device also includes a bubble sensor, which is set inside the housing 100 to detect the bubble content in the blood and transmit the data to the external system module via Bluetooth, infrared or other means, so that the system module can obtain the bubble status of the housing 100 at the current state and take corresponding measures in time to avoid large amounts of blood clotting caused by bubbles. The bubble sensor can be made of ceramic material, semiconductor material or organic material.

[0067] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments, and various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof can be combined with each other unless otherwise specified.

Claims

1. A multifunctional artificial organ device, characterized in that, include: The housing has an internal cavity, and the housing has a blood inlet and a blood outlet, both of which are connected to the cavity. Multiple blood tubing bundles are provided, each blood tubing bundle is housed within the receiving cavity, one end of each blood tubing bundle is connected to the blood inlet, and the other end of each blood tubing bundle is connected to the blood outlet; A hydrogel, filling the containment cavity, comprises a gel layer and allogeneic therapeutic cells. The allogeneic therapeutic cells are encapsulated within the gel layer and absorb substances precipitated from the blood tubules, secreting therapeutic factors into the containment cavity. The containment cavity also includes two mounting plates placed within the housing and connected to the inner wall of the housing. Both ends of the blood tubules are fixed to the two mounting plates. Each mounting plate has mounting holes into which the ends of the blood tubules are inserted. The two mounting plates divide the containment cavity into a first buffer chamber, a blood flow chamber, and a second buffer chamber. The blood flow chamber is located between the two mounting plates. The blood inlet communicates with the first buffer chamber, and the blood outlet communicates with the second buffer chamber. The blood tubules include multiple blood flow tubes arranged side-by-side to form the blood tubules. Both ends of the blood tubules are provided with sealing portions inserted into the mounting holes, and the blood flow tubes are fixedly connected at the sealing portions.

2. The multifunctional artificial organ device according to claim 1, characterized in that, The mounting plate includes two oppositely arranged mounting portions with a gap between them. Each mounting portion has multiple spaced mounting openings. The mounting openings of the two mounting portions correspond one-to-one and face each other. Two mounting openings are inserted into each side of each blood tube bundle. Adjacent blood tube bundles and the mounting portions enclose a reaction chamber, and the hydrogel fills the reaction chamber.

3. The multifunctional artificial organ device according to claim 1, characterized in that, The housing includes at least one partition located between the two mounting plates, the edge of the partition being connected to the inner wall of the housing, the partition dividing the blood flow chamber into multiple perfusion units, the partition having through holes through which the blood tubing passes.

4. The multifunctional artificial organ device according to claim 1, characterized in that, The housing includes an infusion port that communicates with the blood flow chamber, and a valve for opening and closing the infusion port is provided at the infusion port.

5. The multifunctional artificial organ device according to claim 1, characterized in that, The housing includes a first outer shell and a second outer shell, which are movably connected to close or open the receiving cavity.

6. The multifunctional artificial organ device according to claim 1, characterized in that, The housing also includes a plurality of filter screens, which are housed within the second buffer cavity, and the edges of the filter screens are connected to the inner wall of the housing.

7. The multifunctional artificial organ device according to claim 6, characterized in that, The housing also includes two flushing ports, which are respectively connected to the first buffer chamber and the second buffer chamber.

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